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427 results on '"Tian, Guangming"'

106. Salvage treatment with anlotinib for advanced non‐small cell lung cancer

Author

Wu, Di, primary, Nie, Jun, additional, Dai, Ling, additional, Hu, Weiheng, additional, Zhang, Jie, additional, Chen, Xiaoling, additional, Ma, Xiangjuan, additional, Tian, Guangming, additional, Han, Jindi, additional, Han, Sen, additional, Long, Jieran, additional, Wang, Yang, additional, Zhang, Ziran, additional, and Fang, Jian, additional

Published
2019
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107. Real‐world data on EGFR/ALK gene status and first‐line targeted therapy rate in newly diagnosed advanced non‐small cell lung cancer patients in Northern China: A prospective observational study

Author

Liang, Hongge, primary, Song, Xia, additional, Zhang, Yuhui, additional, Zhang, Shucai, additional, Li, Fang, additional, Fang, Jian, additional, Li, Junling, additional, Liang, Li, additional, Nie, Ligong, additional, Ma, Kewei, additional, Zhang, Liangming, additional, Wang, Xiaohong, additional, Xu, Junjun, additional, Wei, Yanxia, additional, Wang, Jinghui, additional, Song, Qi, additional, Tian, Guangming, additional, Mu, Yuxin, additional, Gu, Yangchun, additional, Yang, Lei, additional, Sun, Ping, additional, Zhong, Wei, additional, Zhao, Jing, additional, Xu, Yan, additional, Chen, Minjiang, additional, and Wang, Mengzhao, additional

Published
2019
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116. The change of organic matter in sewage sludge composting and its influence on the adsorption of pentachlorophenol (PCP)

Author

He Yunfeng, Liu Defu, Chen Huanyu, Tian Guangming, Lou Liping, and Chen Fang

Subjects
Pentachlorophenol, Health, Toxicology and Mutagenesis, engineering.material, Waste Disposal, Fluid, Soil, chemistry.chemical_compound, Soil Pollutants, Environmental Chemistry, Organic chemistry, Humic acid, Benzopyrans, Organic matter, chemistry.chemical_classification, Sewage, Chemistry, Compost, Sorption, General Medicine, Pollution, Humus, Environmental chemistry, engineering, Humin, Adsorption, Waste disposal
Abstract

Due to the abundance of organic matter in compost, the addition of compost to soil can promote the adsorption of pesticides. However, few studies have examined the influence of the composting duration on the organic matter (OM) transformation and adsorption capacity of the compost. In this study, a mixture of sewage sludge and straw was composted, and then the physicochemical properties of various OM were studied. Additionally, the sorption capacities of humic acid (HA), humin (HM), humic acid + humin, and fulvic acid (FA) + humic acid + humin extracted from composts of different stages toward pentachlorophenol (PCP) were compared. The sorption data can be well-described by the Freundlich model, and the sorption capacity of PCP on HM is the strongest of all organic components. After 120 days of composting, the sorption abilities of HA and HM increased by 54.76 and 36.73 %, respectively, which corresponds with increases in the aromatization degree, BET specific area, and pore volume and with a decrease in acid functional groups. The sorption ability of HA and HM increased by 54.76 and 36.73 % due to the increase of the aromatization degree. However, the sorption capacity of the compost decreased by 51.2 %, which resulted from a decrease in total organic matter content and from the interaction between organic components in composts. This could be verified by the sequence of the sorption capacity: HM > HM + HA > HM + HA + FA > HA. The contribution of humus to the sorption of PCP onto compost is approximately 41 to 55 %, and it increases with composting time. Therefore, it is possible that other components are present that affect the adsorption of PCP on composts.

Published
2014

117. pH-dominated niche segregation of ammonia-oxidising microorganisms in Chinese agricultural soils

Author

Liu Wei-ping, Hu Baolan, Wang Wei, Xu Xiangyang, Shen Lidong, Liu Shuai, Lou Liping, Tian Guangming, and Zheng Ping

Subjects
China, Bacteria, Ecology, biology, Microorganism, Molecular Sequence Data, Community structure, Niche segregation, Agriculture, biology.organism_classification, Archaea, Nitrification, Applied Microbiology and Biotechnology, Microbiology, Soil, Ammonia, Soil pH, Soil water, Botany, Oxidation-Reduction, Nitrogen cycle, Soil Microbiology
Abstract

Ammonia-oxidising archaea (AOA) are increasingly recognised as the primary mediators of soil ammonia oxidation, particularly in acidic soils. To explore the niche segregation of AOA and ammonia-oxidising bacteria (AOB) and the potential effect of this segregation on nitrification rates and the nitrogen cycle in Chinese agricultural soils, AOA and AOB amoA gene databases were established, and 454 high-throughput sequencing was used to investigate the key factors leading to the niche segregation of these two types of microorganisms. qPCR results demonstrated that there were more functional genes for AOA than for AOB in most of the soils. AOA diversity was higher than AOB diversity in most of the soils with AOA operational taxonomic units (OTU) numbers ranging from 40 to 169 and AOB OTU numbers ranging from 18 to 105. pH was the most important factor influencing the community structure of AOA ( P < 0.01) and AOB ( P < 0.05), and acidophilic AOA (i.e. Nitrosotalea -related sequences) were dominant in soils with pH values below 6.0. In addition, AOA amoA gene copy numbers were significantly positively correlated with pH ( P < 0.05), the ratio of AOA OTU numbers/AOB OTU numbers was significantly negatively correlated with pH ( P < 0.05), and the percentage of sequences represented by the Nitrosotalea cluster was significantly negatively correlated with pH ( P < 0.01).

Published
2014

118. Modeling the fate of fertilizer N in paddy rice systems receiving manure and urea

Author

Li Liang, Yuan Junli, He Miaomiao, Li Hua, Tian Guangming, and Liang Xinqiang

Subjects
Field experiment, food and beverages, Soil Science, Ammonia volatilization from urea, engineering.material, Manure, chemistry.chemical_compound, Human fertilization, Agronomy, chemistry, engineering, Urea, Environmental science, Paddy field, Fertilizer, Leaching (agriculture)
Abstract

Manure is one of the most important N sources in paddy rice systems, while it poses a great challenge in meeting rice N requirement and simultaneously reduces adverse environmental impacts. The main objective of this study was to design a simple model for assessing N fate in swine manure amended paddy rice systems. A field experiment was conducted for three cropping seasons to determine the effectiveness of different swine manure amended levels (15%, 30%, and 45% of total N applied) on N transformations and seasonal N fate. Based on field observation data, simulation results clearly showed peaks of various N transformation rates appeared within 2 ~ 3 days after each fertilization. There was an apparent contribution of manure N on N uptake and loss when amount of manure applied was at optimum. However, at supra optimal rate, addition of manure N showed no effect on N uptake of crop and the corresponding N transformations. Across three levels, seasonal ammonia volatilization accounted for 35.6% ~ 38.0% of total N applied, N uptake was 36.7% ~ 41.1%, while N losses via vertical leaching, lateral seepage were 3.9% ~ 4.5% and 4.4% ~ 4.8%, respectively. These results were well predicted by our specific designed model, indicating the model performed effectively at assessing individual transformation process and its associated N fate and help develop efficient management strategies for swine manure amended paddy rice systems.

Published
2014

119. Efficacy, safety and predictive indicators of apatinib after multilines treatment in advanced nonsquamous nonsmall cell lung cancer: Apatinib treatment in nonsquamous NSCLC

Author

Wu, Di, primary, Liang, Li, additional, Nie, Ligong, additional, Nie, Jun, additional, Dai, Ling, additional, Hu, Weiheng, additional, Zhang, Jie, additional, Chen, Xiaoling, additional, Han, Jindi, additional, Ma, Xiangjuan, additional, Tian, Guangming, additional, Han, Sen, additional, Long, Jieran, additional, Wang, Yang, additional, Zhang, Ziran, additional, Xin, Tao, additional, and Fang, Jian, additional

Published
2018
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123. Effect of composting process on phytotoxicity and speciation of copper, zinc and lead in sewage sludge and swine manure

Author

He Miaomiao, Li Wenhong, Wu Donglei, Liang Xinqiang, and Tian Guangming

Subjects
Conservation of Natural Resources, Time Factors, Swine, engineering.material, Feces, Soil, Dissolved organic carbon, Animals, Organic matter, Waste Management and Disposal, chemistry.chemical_classification, Sewage, Compost, Environmental engineering, Biodegradable waste, Manure, Refuse Disposal, Bioavailability, Zinc, Lead, chemistry, Environmental chemistry, engineering, Phytotoxicity, Environmental Pollution, Copper, Sludge
Abstract

The concentration and bioavailability of heavy metals in composted organic wastes have negative environmental impacts following land application. Aerobic composting procedures were conducted to investigate the influences of selected parameters on heavy metal speciation and phytotoxicity. Results showed that both of sewage sludge (SSC) and swine manure (SMC) composting systems decreased the pH, the content of organic matter (OM) and dissolved organic carbon (DOC), and total amounts of Cu, Zn and Pb. Sequential extraction showed that readily extractible fractions of exchangeable and carbonate in Cu and Zn increased during SSC composting but decreased during SMC composting, thus their bioavailability factors (BF) enhanced in SSC but declined in SMC. The fraction of reducible iron and manganese (FeMnOX) of Cu and Zn in SSC and FeMnOX-Cu in SMC decreased, but FeMnOX-Zn in SMC gradually increased in the process of compost. In contrast, the changes of Pb distributions were similar in two organic wastes. Pb was preferentially bound to the residual fraction and its BF decreased. The evolution of heavy metal distributions and BF depended on not only total metal concentrations but also the other properties, such as pH, decomposition of OM and decline of DOC. The germination rate (RSG), root growth (RRG) and germination index (GI) of pakchoi (Brassica Chinensis L.) increased during the composting process. Linear regression analysis demonstrated that GI, which could represent phytotoxic behavior to the plants, could be poorly predicted by BF or total amount of metals, i.e., BF-Zn, T-Cu. However, the inclusion of other physicochemical parameters (pH, OM and DOC) could enhance the linear regression significances (R).

Published
2009

129. Efficacy and toxicities of gemcitabine and cisplatin combined with endostar in advanced thymoma and thymic carcinoma.

Author

Wang, Yang, Nie, Jun, Dai, Ling, Hu, Weiheng, Chen, Xiaoling, Han, Jindi, Ma, Xiangjuan, Tian, Guangming, Han, Sen, Long, Jieran, Zhang, Ziran, and Fang, Jian

Subjects
ANTINEOPLASTIC agents, CISPLATIN, NEOVASCULARIZATION inhibitors, THERAPEUTIC use of antimetabolites, ACADEMIC medical centers, CANCER chemotherapy, CANCER invasiveness, DRUG toxicity, METASTASIS, SURVIVAL, TUMOR classification, THYMUS tumors, TREATMENT effectiveness, MEDICAL records, RETROSPECTIVE studies, DISEASE progression, THYMOMA, PROGNOSIS, THERAPEUTICS
Abstract

Background: Thymoma and thymic carcinoma are rare thymic epithelial tumors. We investigated the efficacy of first‐line gemcitabine and cisplatin (GP) chemotherapy versus gemcitabine and cisplatin chemotherapy combined with the anti‐angiogenic drug endostar (GP + E) in advanced thymoma and thymic carcinoma. Methods: The records of 45 patients with invasive metastatic thymomas or thymic carcinomas treated with GP as first‐line therapy between August 2008 and July 2017 at the Department of Respiratory Medicine, Peking University Cancer Hospital and Institute were retrospectively reviewed. Results: Eighteen patients (75%) in the GP + E group achieved a partial response and six (25%) had stable disease. In GP only group, nine (42.8%) patients achieved a partial response, 11 (52.4%) had stable disease, and one (4.8%) had progressive disease. The GP + E group had a significantly higher overall response rate (75% vs. 42.9%; P = 0.028), and median progression‐free survival (PFS) and overall survival (OS) of 19 and 76 months, respectively. In the GP only group, median PFS and OS were 16 and 29 months, respectively. PFS and OS were not significantly different between the groups. Conclusions: GP has moderate efficacy and could represent a suitable first‐line therapy for thymic carcinoma and thymoma. Chemotherapy combined with endostar could improve the overall response rate, but did not prolong PFS or OS. [ABSTRACT FROM AUTHOR]

Published
2019
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130. Retrospective study of surgery versus non-surgical management in limited-disease small cell lung cancer

Author

Zhang, Jie, Li, Shaolei, Chen, Xiaoling, Han, Jindi, Nie, Jun, Dai, Ling, Hu, Weiheng, Tian, Guangming, Ma, Xiangjuan, Han, Sen, Wu, Di, Zheng, Qingfeng, Yang, Yue, and Fang, Jian

Subjects
Original Articles
Abstract

The role of surgery in limited small cell lung cancer (SCLC) is still controversial. To assess the role of surgery in SCLC we performed a retrospective analysis of survival in a group of limited stage patients, who were managed with trimodal therapy including surgery, or with chemotherapy and radiotherapy.We performed a retrospective survival analysis in a series of 153 limited stage SCLC patients treated between 1995 and 2013. Kaplan-Meier survival analysis and Cox regression analysis were used to calculate the overall survival of the surgical and non-surgical groups.Median survival in all patients was 21.5 months. Median survival for surgical and non-surgical patients was 30.5 months and 16.9 months, respectively. The survival curves for the two arms are significantly different (P0.01). In multivariate analysis, the benefit of surgical treatment and thoracic radiotherapy varied in a time-dependent fashion.Our results suggest that surgery added to chemotherapy and radiotherapy may be associated with a therapeutic benefit in limited SCLC.

Published
2014

132. Efficacy and safety of extended use of platinum-based doublet chemotherapy plus endostatin in patients with advanced nonsmall cell lung cancer

Author

Hu, Weiheng, primary, Fang, Jian, additional, Nie, Jun, additional, Dai, Ling, additional, Zhang, Jie, additional, Chen, Xiaoling, additional, Ma, Xiangjuan, additional, Tian, Guangming, additional, Wu, Di, additional, Han, Sen, additional, Han, Jindi, additional, Wang, Yang, additional, and Long, Jieran, additional

Published
2016
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133. Clinical characteristics associated with metastatic NSCLC harboring ALK rearrangements in Chinese patients.

Author

Tian, Guangming, primary, Zhao, Xinliang, additional, Nie, Jun, additional, Dai, Ling, additional, Hu, Weiheng, additional, Zhang, Jie, additional, Chen, Xiaoling, additional, Han, Jindi, additional, Ma, Xiangjuan, additional, Wu, Di, additional, Han, Sen, additional, Wang, Yang, additional, Long, Jieran, additional, and Fang, Jian, additional

Published
2016
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134. Clinical characteristics associated with non-small-cell lung cancer harboring ALK rearrangements in Chinese patients

Author

Tian, Guangming, primary, Zhao, Xinliang, additional, Nie, Jun, additional, Dai, Ling, additional, Hu, Weiheng, additional, Zhang, Jie, additional, Chen, Xiaoling, additional, Han, Jindi, additional, Ma, Xiangjuan, additional, Wu, Di, additional, Han, Sen, additional, Long, Jieran, additional, Wang, Yang, additional, and Fang, Jian, additional

Published
2016
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141. Circulating PD ‐ L 1 in NSCLC patients and the correlation between the level of PD ‐ L 1 expression and the clinical characteristics

Author

Zhang, Jie, primary, Gao, Jing, additional, Li, Yanyan, additional, Nie, Jun, additional, Dai, Ling, additional, Hu, Weiheng, additional, Chen, Xiaoling, additional, Han, Jindi, additional, Ma, Xiangjuan, additional, Tian, Guangming, additional, Wu, Di, additional, Shen, Lin, additional, and Fang, Jian, additional

Published
2015
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143. Product of Two Time-Frequency Representations

Author

Chen Guangju and Tian Guangming

Subjects
Reduction (complexity), Signal processing, Computational complexity theory, Time–frequency representation, Speech recognition, Short-time Fourier transform, Wigner distribution function, Spectrogram, Algorithm, Time–frequency analysis, Mathematics
Abstract

Each time-frequency representation (TFR) has both its own advantages and disadvantages for nonstationary signal analysis. In this paper, an algorithm, nominated as product method, is proposed, which gains one new TFR by the product of two TFRs and integrates their advantages for some applications, especially keeps Wigner distribution's (WD's) auto-term concentration and reduces the crossterms. Potential applications to some TFRs are discussed, such as short time Fourier transform and its spectrogram, Margenau-Hill-spectrogram distribution and WD. Then some instances illustrate that this simple method is valid and practicable, and has much less computational complexity except for the initial TFRs and better visual effect in virtue of auto-term concentration enhancement and cross-term reduction.

Published
2007

145. Retrospective study of surgery versus non-surgical management in limited-disease small cell lung cancer

Author

Zhang, Jie, primary, Li, Shaolei, additional, Chen, Xiaoling, additional, Han, Jindi, additional, Nie, Jun, additional, Dai, Ling, additional, Hu, Weiheng, additional, Tian, Guangming, additional, Ma, Xiangjuan, additional, Han, Sen, additional, Wu, Di, additional, Zheng, Qingfeng, additional, Yang, Yue, additional, and Fang, Jian, additional

Published
2014
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