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The role of protein-tyrosine phosphorylation in the signal transduction of platelet activating factor (PAF) was investigated in rabbit platelets with a range of synthetic compounds that inhibit protein-tyrosine kinases. In particular, erbstatin (IC50 approximately 20 micrograms/ml) abrogated a wide range of platelet responses to PAF, including tyrosine phosphorylation of cellular proteins, polyphosphoinositide turnover, activation of membranous protein kinase C, platelet aggregation, and serotonin secretion. With about a third of the potency of erbstatin, compound RG50864 also inhibited many of these responses, whereas at 100 micrograms/ml, genistein, 670C88 and ST271 were without effect. Finally, the ability of thrombin to cause platelet aggregation and serotonin secretion was also compromised by erbstatin.

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A method of surgical repair of ectropion of mucosa occurring after an improperly-performed amputative type of hemorrhoidectomy has been described. Results after anoplasty, employing the S-plasty technic, have been excellent.

The records of 200 patients with adenomatous polyps of the rectum, followed 3 to 15 years, were reviewed. Rectal adenomas were most prevalent in patients between the ages of 45 to 65 years. Men predominated over women (ratio, 1.6 : 1.0). The recurrence rate of adenomatous polyps of the rectum was 31 per cent.

Xi, [3], 161 p. il. 23 cm., Beare, Thomas Hudson, Sir, tr. 1859, (Dlps) ABR3146.0001.001., (Lccallno) QA821.C915 E5 1890., Http://name.umdl.umich.edu/ABR3146.0001.001.

"This medal is awarded to personnel who were assigned or attached to and present for duty for at least 120 days during the period June 26, 1948 and Sept. 30, 1949, inclusive, with any of the units cited in Department of the Air Force general orders for participating in the Berlin Airlift or for direct support of the Berlin Airlift."--Air Force Personnel Center., Obverse of medal decpicts a C-54 airplane over a Berlin coat of arms centered in a wheat wreath. Reverse has the inscriptions, "FOR HUMANE ACTION", and, "TO SUPPLY NECESSITIES OF LIFE TO THE PEOPLE OF BERLIN GERMANY."

To help improve therapeutic results for treatment of bone tumors, high intensity focused ultrasound (HIFU) is being investigated as a non-invasive alternative to surgery and radiotherapy. HIFU ablative treatments require an imaging modality for guidance, and magnetic resonance (MR) imaging is currently the strongest choice as it is able to provide temperature mapping throughout the treatment process. Unfortunately, the temperature feedback that is critical to ensuring safety and optimal soft tissue ablation is often unobtainable in bone structures. As an alternative to obtaining feedback, this project is focused on developing a simulator that is capable of predicting the temperature distribution in and around bone tissue during HIFU therapy. Having such a simulation would provide a better understanding of the thermal dosages incurred by the bone during HIFU treatment of tumors.

A machine vision system that can address a number of board, lineal, cant, and flitch inspection problems by incorporating all the sensors needed to address the surface feature detection problem, the three-dimensional shape detection problem, and the internal feature detection problem. To detect surface features, two color cameras are employed, one for imaging each of the major faces of a board, lineal, cant, or fitch. To address the three-dimensional shape detection problem, a high speed laser profiling device is employed. An x-ray scanning system is employed to detect internal features. The system is able to process material in a species-independent manner by using a histogram-based segmentation procedure for analyzing both the camera imagery and the x-ray imagery; and can detect small defects by removing the effects of large features from the histograms once they have been detected. The system also utilizes redundant information from the set of multiple sensors to improve system accuracy. The volume of data that must be analyzed due the use of three sets of sensors is reduced by ordering the way the data is analyzed. The laser profile data is processed first, followed by the x-ray data and the color imagery. Finally, the system reduces the required volume of data by incorporating a crack/check preserving filter. This filter is implemented in special purpose hardware, and filters the color imagery as it is collected.