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Hybrid nucleic acid nanostructures partition architectural and functional roles between ribonucleic acid (RNA) joints and deoxyribonucleic acid (DNA) connectors. Nanoshapes self-assemble from nucleic acid modules through synergistic stabilization of marginally stable base pairing interactions within circularly closed polygons. Herein, we report the development of hybrid nanoshapes that include multiple different RNA modules such as internal loop and three-way junction (3WJ) motifs. An iterative mix-and-match screening approach was used to identify suitable DNA connectors that furnished stable nanoshapes for combinations of different RNA modules. The resulting complex multicomponent RNA-DNA hybrid nanoshapes were characterized by atomic force microscopy (AFM) imaging. Our research provides proof of concept for modular design, assembly and screening of RNA-DNA hybrid nanoshapes as building blocks for complex extended nucleic acid materials with features at the sub-10 nm scale.

INTRODUCTION: ST segment elevation myocardial infarction is a common reason for out-of-hospital cardiac arrest in adult patients. The surveillance of the ST segment in the electrocardiogram is limited to visual presentation. However, the ST segment can change during the course of treatment. If ST elevation is present immediate coronary revascularization is needed, therefore detecting ST elevation changes the treatment fundamentally. Sonification of the ST segment is a new method which enables the emergency team to detect intermediate changes of the ST segment.; MATERIAL AND METHODS: We have chosen two sonification designs which were introduced to two groups, medical students and computer science students. Twenty-one participants took part in the study. The sonification was designed for evaluation of the ST segment. The user was supposed to become empowered to distinguish between no, medium-low, medium-high or extreme ST elevation by listening to the sonification. The two groups were asked to evaluate the sounds for possible ST elevation as well as for aesthetics and usability. In a second study twenty-five medical students were taking part in a medical scenario in which sonification was played during a simulated case. The patient was suffering from a myocardial infarction, ST elevation was transient and sonification sounds were changing appropriately. The students were supposed to detect these changes and act accordingly by modifying the treatment.; RESULTS: Both groups were able to classify ST segment elevation by listening to the sonification samples. The higher the ST segment, the better was the detection rate overall. In all of the three categories (pleasantness, informativeness and long-term listening) the Water Ambience sonification was rated higher compared to the Polarity sonification. Moreover, in the two groups that took part in the study, we found a significant difference when comparing classification performance using both sonification designs. For the group of medical students as t(20) = 4.31, p = 3.44 * 10-4, p < 0.01 and for the computer science students as t(19) = 3.40, p = 9.39 * 10-6, p < 0.01. In the simulated medical scenario participants indicated that 96% detected the ST elevation. 60% stated that sonification played a role whereas for 32% it did not play a role for the detection of ST elevation.; CONCLUSIONS: Sonification has the potential to play an important role as a new supporting tool for the surveillance of the ST segment during the care of patients with suspicion of myocardial infarction. It can be helpful to differentiate between ST segment elevation myocardial infarction and non-ST segment myocardial infarction especially if ST elevation is transient. Furthermore, sonification is viewed as pleasant to listen to and might not contribute to alarm fatigue. Copyright © 2022 Elsevier Inc. All rights reserved.

The preparation of nucleic acid nanostructures has relied predominantly on procedures of additive fabrication in which complex architectures are assembled by concerted self-assembly and sequential addition of building blocks. We had previously established RNA-DNA hybrid nanoshapes with modular architectures that enable multistep synthetic approaches inspired by organic molecular synthesis where additive and transformative steps are used to prepare complex molecular architectures. We report the establishment of module replacement and strand exchange as synthetic transformations in nucleic acid hybrid nanoshapes, which are enabled by minimally destabilizing sequence elements such as a single unpaired overhang nucleotide or a mismatch base pair. Module exchange facilitated by thermodynamic lability triggers adds a powerful transformative approach to the repertoire of additive and transformative synthetic methods for the preparation of complex composite materials.

Mass-selective threshold photoelectron spectroscopy in the gas phase was employed to characterize the dialkynyl triplet carbenes pentadiynylidene (HC5H), methylpentadiynylidene (MeC5H), and dimethylpentadiynylidene (MeC5Me). Diazo compounds were employed as precursors to generate the carbenes by flash pyrolysis. The R1-C5-R2 carbon chains were photoionized by vacuum ultraviolet (VUV) synchrotron radiation in photoelectron photoion coincidence (PEPICO) experiments. High-level ab initio computations were carried out to support the interpretation of the experiments. For the unsubstituted pentadiynylidene (R1 = R2 = H) the recorded spectrum yields an adiabatic ionization energy (IEad) of 8.36 ± 0.03 eV. In addition, a second carbene isomer, 3-(didehydrovinylidene)cyclopropene, with a singlet electronic ground state, was identified in the spectrum based on the IEad of 8.60 ± 0.03 eV and Franck-Condon simulations. We found that multireference computations are required to reliably calculate the IEad for this molecule. CASPT2 computations predicted an IEad = 8.55 eV, while coupled-cluster computations significantly overestimate the IE. The cyclic isomer is most likely formed from another isomer of the precursor present in the sample. Stepwise methyl-substitution of the carbene leads to a reduction of the IE to 7.77 ± 0.04 eV for methylpentadiynylidene and 7.27 ± 0.06 eV for dimethylpentadiynylidene. The photoionization and dissociative photoionization of the precursors is investigated as well.

Elaphoglossum multisquamosum Bonap. in Notes Pt��ridol. 1: 67. 1915 (Fig. 2). ��� Elaphoglossum poolii var. multisquamosum (Bonap.) Tardieu in Humbert, Fl. Madagascar 5(2): 54. 1960. Lectotypus (hic designatus): MADAGASCAR. Reg. Analamanga [Prov. Antananarivo]: �� Halfy ��, Ilafy, [18��51"S 47 ��33,5"E], I.1906, D���Alleizette 42 (P [P00466228]!). Syntypus: MADAGASCAR. Reg. Analamanga [Prov. Antananarivo]: Ambohimanga, [18��45'S 47 ��33'E], 12.VI.1905, D���Alleizette 167 (P [P00466229, P00466230]!). Rhizomes courtement rampant parfois ascendant, 3,5��� 6,5 mm de diam��tre, ramifi��s, plus ou moins glutineux, dens��ment couverts d�����cailles au moins �� l���apex (Fig. 2I, L); ��cailles du rhizome peu �� enti��rement appliqu��es (et alors non distinctes les unes des autres), ov��es �� lanc��ol��es, 2,5��� 6(���10) �� 1���2 mm, la plupart brun clair mat, scarieuses, bases cord��es, apex cun��iformes �� att��nu��s, marges subenti��res avec des glandes sessiles et des cils courts (Frondes st��riles dress��es �� ��tal��es (Fig. 2D, E), ins��r��es sur au moins deux rangs peu distincts, distantes de moins de 5 mm, longues de 8��� 47 cm. P��tioles longs de 2���16 cm, repr��sentant g��n��ralement moins de la moiti�� de la longueur de la fronde, 0,5���1,5 mm de diam��tre, dens��ment couverts d�����cailles; ��cailles du p��tiole dress��es en toutes directions, lanc��ol��es, 2���6 �� 1���1,5 mm, roux clair mat, translucides, scarieuses, bases pseudo-pelt��es, apex cun��iformes �� acumin��s, marges sub-enti��res �� cili��es avec plus de 10 cils de chaque c��t��, courts (Limbe st��rile ��troitement elliptique ou oblanc��ol��, rarement lin��aire, 6���32 �� 1,3���4 cm, base cun��iforme �� att��nu��e, apex arrondi ou aigu, texture chartac��e �� coriace, les deux faces et les marges dens��ment ��cailleuses jusqu����� masquer parfois la face inf��rieure du limbe, face sup��rieure glabrescente (Fig. 2G���H); ��cailles du limbe imbriqu��es, ov��es �� lanc��ol��es, 1,5���3 �� 0,5���1 mm, rousses, souvent blanches sur la face sup��rieure du limbe, translucides, scarieuses, base cord��e �� h��miinfundibuliforme, apex obtus, arrondi ou cun��iforme, marges cili��es avec 10���15 cils aciculaires de chaque c��t��, souvent aussi longs que la largeur du corps de l�����caille (Fig. 2A); nervure m��diane pro��minente et arrondie sur la face inf��rieure, aplatie sur la face sup��rieure; nervures lat��rales parfois l��g��rement pro��minentes sur la face inf��rieure, simples ou 1���2-bifurqu��es, libres jusqu����� leur apex. Frondes fertiles plus longues que les st��riles, atteignant 60 cm, plus ��troites Distribution et ��cologie. ��� Elaphoglossum multisquamosum est pr��sent �� Madagascar au centre et au sud (et une r��colte �� Mahajanga), dans les domaines phytog��ographiques du Centre et de l���Ouest (HUMBERT, 1955), �� 100���2650 m d���altitude. Elle pousse dans la for��t sempervirente r��siduelle, le long des cours d���eau et dans les ravins o�� elle est peu fr��quente. C���est une plante ��pilithe ou terrestre, rarement ��piphyte. A la R��union, une seule station est connue, dans le cirque de Cilaos, �� plus de 1950 m, au niveau de la Plaine aux Fraises sous le rempart des trois Salazes. La plante s���y d��veloppe sur une falaise rocheuse avec d���autres herbac��es communes des prairies d���altitude, dans une zone de transition entre ��for��t de bois de couleurs d���altitude�� (Dombeya spp.) et v��g��tation ��rico��de (Erica spp.). Selon la typologie des habitats ��Corine Biotope�� (STRASBERG et al., 2010), le code habitat [49.214] de la station est qualifi�� de for��t semi-s��che de transition vers l�����tage m��sotherme des cirques et grandes vall��es sous le vent, ��tage �� Dombeya spp. A La R��union, l���esp��ce pourrait ��tre menac��e par la pr��sence de l���exotique envahissante Erigeron karvinskianus DC. (C. Lavergne, comm. pers.). Notes. ��� Les trois sp��cimens types (deux r��coltes) repr��sentent tous la m��me esp��ce, Elaphoglossum multisquamosum, et deux portent la mention ��Original�� de la main de Bonaparte, auteur de l���esp��ce. Nous avons choisi comme lectotype le sp��cimen [P00466228] avec deux plantes fertiles. Elaphoglossum multisquamosum est polymorphe �� Madagascar, avec deux morphologies extr��mes, la premi��re �� rhizome tr��s glutineux couvert d�����cailles appliqu��es et la seconde �� rhizome peu glutineux couvert d�����cailles plut��t dress��es dont certaines pr��sentent une marge marron brillant; cependant, les interm��diaires entre ces morphologies existent. La forme de l���apex du limbe et la taille des ��cailles du limbe sont aussi variables. Sp��cimens observ��s. ��� MADAGASCAR. Reg. Alaotra-Mangoro [Prov. Toamasina]: Analanomby, for��t du N du pays Sihanaka, 2.IX.1937, Jard. Bot. 3016 (P). Reg. Amoron���i Mania Prov. Fianarantsoa]: au N d���Ambatoandrano, 7.II.2001, Andriamihajarivo 45 (P); env. d���Ambatofinandrahana, 21.II.1938, Decary 13200 (P); montagnes �� l���W d���Itremo (W Betsileo), 17.I���22.IV.1955, Humbert 28227 p.p. (P [P 00915740, P 01556626]); juste �� l���E du col d���Itremo, 26.XI.1993, Labat 2439 (P); Fiadanana, Ilaka, Ambositra, 20.III.1960, Peltier 2145 (P); Fianarantsoa, Mania, IV.1919, Perrier de la B��thie 12575 (P). Analamanga [Prov. Antananarivo]: Mandraka, III.1961, Bosser 15215 p.p. (P [P00611253]); Ambohidempona, 26.VII.1911, Colin s.n. (P); Vodivato, montagne, 5.XI.1946, Cours 3060 (P); Mandraka, VIII.1906, D���Alleizette 213 (P); Antananarivo, IX.1921, Decary s.n. (P00611275); Ambohimanga, 27.III.1921, Decary 489 (P); Tananarive (foss��s du Fort Voyron), 11.III.1928, Decary 6168 (P); Andramasina, 30 km SSE Tananarive, 17.II.1960, Leandri 3088 (P); Ambohimanga, �� 20 km de Tananarive, 1919, Raharijaona 9 (P); RS d���Ambohitantely, 8.XII.1997, Rakotondrainibe 4445 (P); for��t de la Mandraka, 17.VIII.1906, Rotereau s.n. (P [2 planches]); Tananarive, 1.IV���30.IV.1915, Waterlot s.n. (P [6 planches]). Reg. Androy [Prov. Toliara]: Ambohibe, s.d., Decary 4217 (P). Reg. Anosy [Prov. Toliara]: Mt. Itrafanaomby (Ankazondrano) et ses contreforts SW (Haut Mandrare), XII.1933, Humbert 13521 (P); massif de l���Andohahela (SE), I.1934, Humbert 13589 (P); R.N.I. d���Andohahela, versant E et sommet du Trafon���omby, 23.XI.1995, Rakotondrainibe 3186 (P [P00067309]); ibid. loco, versant du Trafon���omby, 28.XI.1995, Rakotondrainibe 3216 (P). Reg. Boeny [Prov. Mahajanga]: Mt Namiaka (Boeny E), VIII.1905, Perrier de la B��thie 7454 (P). Reg. Bongolova [Prov. Antananarivo]: for��t de Bongolava (100 km W Tsironomandidy vers Morafenobe), 17.VII.1974, Cremers 3251 (P); Mt Tsitondriana, 15.IV.1941, Jard. Bot. 4757 (P). Reg. Ihorombe [Prov. Fianarantsoa]: Andringitra, distr. Ambalavao autour du lieu-dit Anosibe, 9.V.1957, Cours 5172 (P); Andringitra, distr. Ambalavao au pied du Tsoraha, 10.V.1957, Cours 5179 (P); Pic d���Ivohibe, 23.IX.1926, Decary 5288 (P); Andringitra AP, II.1995, Goodman s.n. (P); Pic Boby, s.d., Homolle 1185 (P); Pic d���Ivohibe (Bara), 5.XI.1924, Humbert 3276 (P); ibid. loco, vall��e de la Riambava et de l���Antsifotra, 27.XII.1924, Humbert 3776 (P); massif du Kalambatitra (centre-sud), Mt. Analatsitendrika, XII.1933, Humbert 11931 (P); Pic d���Ivohibe, haute vall��e de l���Andranomainty, 23.IV.2005, Janssen 2810 p.p. (P [P00590873]); Ambalavao, Anara, R��serve d���Anja, 22.III.2006, Labat 3662 p.p. (P [P00533707]); massif d���Andringitra, IX.1911, Perrier de la B��thie 7563 (P); ibid. loco, III.1921, Perrier de la B��thie 13697 (P); RS d���Ivohibe, �� 6,5 km �� l���ESE du village d���Ivohibe, pr��s de la source de la riv. Andranomainty, 25.X.1997, Rakotondrainibe 4241 (P); ibid. loco, 25.X.1997, Rakotondrainibe 4243 (P); PN de l���Andringitra, for��t de Riambavy, 17.XI.2004, Rouhan 439 (P), Rouhan 443 (P); ibid. loco, for��t de Ramiova, 17.XI.2004, Rouhan 449 (P), Rouhan 450 (P); ibid. loco, for��t de Anjavidilava, 19.XI.2004, Rouhan 471 (P), Rouhan 472 (P), Rouhan 473 (P), Rouhan 474 (P); RS du Pic d���Ivohibe, versant S au S du sommet, for��t dite du ��plateau du Pic��, 16.XI.2011, Rouhan 1397 (P). Reg. Itasy [Prov. Antananarivo]: Ankaratra, Antsahapandrano, 10.II.1942, Decary 17638 (P); Massif de l���Ankaratra, XII.1913, Perrier de la B��thie 7613 (P); Ankaratra, IV.1980, Proisy 225 (P); for��t de Manjakatompo, versant E de l���Ankaratra, VII.1953, Service Forestier 58 (P). Reg. Vakinankaratra [Prov. Antananarivo]: summit Ibity, 5.II.2003, Birkinshaw 1193 (P); Manjakatompo, versant SE, 10.XI.1983, Rakotondrainibe 766 (P); sur la cr��te du Mt Ibity, 21.XI.1912, Viguier 1453 (P); massif du Vakinankaratra, 25.XI.1912, Viguier 1615bis (P); ibid. loco, coteaux bois��s pr��s de Tsinjoarivo, 30.XI.1912, Viguier 1884 (P). Reg. Vatovavy-Fitovinany [Prov. Fianarantsoa]: Ambohimanga Sud, V.1980, Proisy 249 (P). Sine loco: 19.IX.1917, D���Alleizette 212m p.p. (P [P00611279]); s.d., Homolle 1243 (P). LA R��UNION: Cirque de Cilaos, plaine aux Fraises sous l���arr��te des Salazes, 29.V.2010, Robert 1335 (P, herbier priv�� Y. Robert)., Published as part of Robert, Yannis, Thomas, Hermann, Tamon, Jean Maurice & Rouhan, Germinal, 2021, D��couverte �� La R��union de Elaphoglossum multisquamosum (Dryopteridaceae), connue jusqu'alors comme end��mique de Madagascar, pp. 99-104 in Candollea 76 (1) on pages 102-103, DOI: 10.15553/c2021v761a10, http://zenodo.org/record/5683845, {"references":["HUMBERT, H. (1955). Les territoires phytogeographiques de Madagascar. Annee Biol. 31: 439 - 448.","STRASBERG, D., J. DUPONT & J. - C. RAMEAU (2010). Typologie des milieux naturels et des habitats de La Reunion, 2000. DIREN Reunion / Universite de la Reunion. [Revision de fevrier 2010 par F. Picot & M. Saliman]."]}

International audience; A species of the fern genus Elaphoglossum Schott ex J. Sm. (Dryopteridaceae) has been discovered in La Réunion. It is ascribed to Elaphoglossum multisquamosum Bonap., described and known so far as endemic to Madagascar. Taking advantage of this new record, Elaphoglossum multisquamosum is reinstated as a species distinct from the Malagasy endemic Elaphoglossum poolii (Baker) Christ. Morphologically close to Elaphoglossum poolii that is often observed in sympatry in Madagascar, Elaphoglossum multisquamosum has often been treated as a variety of Elaphoglossum poolii or even placed in synonymy of the latter species. We provide a novel, fully detailed description of Elaphoglossum multisquamosum, all critical characters supporting it as distinct from Elaphoglossum poolii, and a comparative map of distribution for the two species in Madagascar and La Réunion. Finally, the name Elaphoglossum multisquamosum is lectotypified.; Une espèce de fougère du genre Elaphoglossum Schott ex J. Sm. (Dryopteridaceae) a été découverte à La Réunion et identifiéecomme Elaphoglossum multisquamosum Bonap., décrite et connue jusqu’alors comme endémique de Madagascar.A l’occasion de cette découverte, Elaphoglossum multisquamosum est confirmée comme une espèce distincte de l’endémiquemalgache Elaphoglossum poolii (Baker) Christ. Morphologiquement proche de Elaphoglossum poolii qui se trouvesouvent en sympatrie à Madagascar, Elaphoglossum multisquamosum a ainsi souvent été considérée au rang variétal deElaphoglossum poolii ou même placée en synonymie de cette dernière. Nous fournissons une nouvelle description morphologiquedétaillée de Elaphoglossum multisquamosum, tous les caractères nécessaires la soutenant comme distincte deElaphoglossum poolii, ainsi qu’une carte de répartition comparative pour les deux espèces à Madagascar et à La Réunion.Enfin, le nom Elaphoglossum multisquamosum est lectotypifié.

This paper introduces sc3nb, a Python package for audio coding and interactive control of the SuperCollider programming environment. sc3nb supports Jupyter notebooks, enables flexible means for sound and music computing such as sound synthesis and analysis and is particularly tailored for sonification. We present the main concepts and interfaces and illustrate how to use sc3nb at hand of selected code examples for basic sonification approaches, such as audification and parameter-mapping sonification. Finally, we introduce TimedQueues which enable coordinated audiovisual displays, e.g. to synchronize matplotlib data and sc3nb-based sound rendition. sc3nb enables interactive sound applications right in the center of the pandas/numpy/scipy data science ecosystem. The open source package is hosted at GitHub and available via the Python Package Index PyPI.

This paper conceptualizes the editor´s question of a possible trust-or-fake dilemma of Corporate Social Responsibility with a rhetorical lens on CSR-Reporting. From a rhetorical point of view, the speaker has to persuade the stakeholders as its audience of the claim: “we are socially responsible”. If the argumentation is judged by the audience as sound, it would trust the organisation. If not, the claim “we are socially responsible” will be judged as a fake. The paper concentrates on the following research questions: - 1. How do organisations employ argumentation to persuade their stakeholders of their corporate social responsibility? - 2. How do they argumentatively cope with the problem of different stakeholder demands? - 3. How do affective appeals interact with the argumentation? With the help of the rhetorical framework various concepts from trust repair literature and neo-institutional theory could be integrated to deepen our understanding of a trust or fake dilemma. Literature on CSR-reporting mainly discusses the gap between talk and action. We focus on another point, the relevance of the CSR-arguments. We introduce several concepts taken from argumentation theory like the distinction between context-abstract and field-dependent topoi and between warrant-using and warrant-establishing argumentation schemes in order to examine companies´ reactions to a loss of trust in their CSR-claim. Drawing on Mayring (2014), a mixed-method approach for content analysis was employed for the empirical analysis. The empirical case study contributed to the model building during the research process and illustrates the application of the model. We identified different phases of the verbal account strategy of Deutsche Bank. In these phases we found remarkable differences in the employment of warrant-establishing and warrant-using argumentations. We found also differences in the use of field-dependent topoi and categorized them following organisational façades.

International audience; Dodonea viscosa(L.) Jacq from Reunion Island (Indian Ocean) was investigated for itsleaf essential oil composition. The plant was extracted by hydrodistillation and its essential oilanalysed by gas chromatography coupled to mass spectrometry. This study revealed that oxygenatednor-diterpenes and diterpenes were one of the major chemical classes (>50%) mainly consisting ofthree modified cyclopropylclerodanes containing a bicyclo[5.4.0]undecane ring system: one newfuranoid norditerpene, dodovisate C, and two furanoid diterpenes, the known methyl dodovisate Aand the new methyl iso-dodovisate A. These three compounds were isolated by liquid chromatographyand their structures established on the basis of spectroscopic studies. The absolute configurationof dodovisate C was elucidated through a joint experimental and theoretical (B3LYP/6-311+G(d,p))electronic circular dichroism study. The relative configurations of methyl dodovisate A and methyliso-dodovisate A were determined using linear regressions of theoretical chemical shifts versusexperimental values with the (B3LYP/6-311+G(d,p)) method.

Vector-borne diseases cause more than 1 million deaths annually. The research into new medicines is urgent, especially as there is currently no specific treatment. In this study, the authors have selected 64 endemic plants from the Mascarene Islands based on their endemism, their medicinal use and their registration in the French Pharmacopeia to evaluate the antiplasmodial, anti-chikungunya and antioxidant activities. The list of these 64 plants including their local name, population, data of collection and voucher number are available in the Supporting Information. Forty active extracts were identified from the 38 species: 22 responded positively to the antiplasmodial activity, 8 to the anti-chikungunya activity and 8 to the antioxidant activity. Six plants demonstrated high antiplasmodial activity (concentration inhibiting 50% of parasitic growth (IC50) 2000 µM of Trolox equivalent per mg/mL of extract: Bertiera borbonica, Erythroxylon laurifolium, Erythroxylon sideroxyloides, I. ammoxylum, P. borbonica, Scolopia heterophylla, Sophora denudata, and Terminalia bentzoe. Some data obtained tend to corroborate the reported traditional use of the plant, such as Z. heterophyllum (antiplasmodial), A. theiformis (anti-chikungunya), and E. laurifolium (antioxidant). ispartof: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS vol:52 issue:5 pages:622-628 ispartof: location:Netherlands status: published

Introduction In Germany, inpatient rehabilitation is a well-established additive option in the therapeutic concept for children and adolescents with diabetes. However, its contribution in pediatric diabetes care is not known exactly. Our objective was to analyze inpatient rehabilitation in pediatric diabetes over eight years in Germany. Methods We requested secondary data from the German Statutory Pension Insurance Scheme to evaluate all completed inpatient rehabilitations for children and adolescents with diabetes (ICD-code E10-14) reimbursed by this institution between 2006 and 2013. For each type of diabetes, we analyzed the distribution of admissions by year, age-group, sex, nationality, and other documented diagnoses. All analyses were conducted via remote computing with IBM SPSS Version 24. Results Between 2006 and 2013, 5,403 admissions to inpatient rehabilitation for 4,746 children and adolescents with diabetes were documented. For type 1 diabetes (T1D; 88.5% of admissions), the number of yearly admissions increased from 458 in 2006 to 688 in 2013 (p=0.013), especially for age-group>5-10. The increase for type 2 diabetes (T2D) was not significant. Admissions were more frequent for girls (53.6%, p≤0.001), age>10-15 years (42.8%, p=0.001), and German nationality (98.5%). Obesity (T1D: 11.1%; T2D: 87.9%) and mental disorders (T1D: 11.6%; T2D: 27.4%) were the most frequent documented diagnoses in addition to diabetes. Conclusion This study provides a comprehensive overview of inpatient rehabilitation for children and adolescents with diabetes over many years in Germany. Until 2013, inpatient rehabilitation remained important in pediatric diabetes care, especially for children with mental disorders or obesity.