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Introduction: Telepharmacy, the application of information and communication technologies in healthcare services, has been adopted in many countries to provide patients with pharmaceutical care. However, it has yet to be widely used in Vietnam. This study was conducted to assess the current status of use and the factors associated with the willingness to use telepharmacy of pharmacists in Vietnam. Methods: A descriptive cross-sectional study was conducted from February to July 2021; 414 pharmacists were recruited to fill in an online survey. Results: Overall, 86.7% of participants have used telepharmacy application and 87.2% of them were willing to apply telepharmacy in pharmacy practice. According to our multivariate analysis, the level of readiness was associated with positive attitude (odds ratio [OR] = 4.67; 95% confidence interval [CI]: 2.26-9.66), and a good behavior (OR = 11.34; 95% CI: 3.84-33.45). Discussion: Developing a telepharmacy system with appropriate features is essential to meet the requirements of pharmacy practice amid the spread of the COVID-19 pandemic., Journal of Pharmacy Technology, 38(2), pp.106-114; 2022

Pham Le An,1,2 Giao Huynh,3 Han Thi Ngoc Nguyen,4 Pham Duong Uyen Binh,5,6 Tam Thao Tuyet Tran,1 Tuong Vy Nguyen,2 Huong Thi Thu Vu,3 Tuan Diep Tran7 1Family Medicine Training Center, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 2Grant and Innovation Center, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 3Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 4Infection Control Department, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam; 5Department of Educational Quality Assurance, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 6Graduate School of Medicine, International University of Health and Welfare, Tokyo, Japan; 7Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VietnamCorrespondence: Giao Huynh,Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang, District 5, Ho Chi Minh City, Vietnam, Tel +84 90 860 8338, Email hgiaoytcc@ump.edu.vnBackground: Educators play a critical role in offering knowledge that is vital to preventing the spread of the COVID-19 in educational settings. This study aims to assess the proportion of preventive practices towards COVID-19 and associated factors among educators in Vietnam.Methods: A cross-sectional study was conducted on educators at the University of Medicine and Pharmacy at Ho Chi Minh City (UMP) using a self-administered questionnaire between June and August 2020. Online surveys and a multivariable logistic regression analysis were used to determine factors associated with practices. Adjusted odds ratio (AOR) and 95% confidence interval (95% CI) were performed using Stata 14.Results: A total of 779 eligible participants were approached, most of them under 50 years (84.1%), around three-fifth were female (61.0%) and lecturers (61.1%), with only 38.1% of them working at hospitals. Overall, the majority of participants had good preventive practices towards COVID-19 (88.6%). Factors identified as being associated with good practices included participants who are lecturers (AOR 1.8, 95% CI: 1.05– 2.97), attending training courses related to COVID-19 (AOR 1.7, 95% CI: 1.05– 2.87), working at hospitals (AOR 2.5, 95% CI: 1.28– 4.76) and having a higher level of knowledge and attitude relating to COVID-19 (AOR 2.8, 95% CI: 1.52– 5.17; AOR 2.8, 95% CI: 1.70– 4.48, respectively) (all p < 0.05).Conclusion: These findings revealed that most educators reported a good level of preventive practices towards COVID-19. However, lower levels of practices still exist towards COVID-19 among participants who were administrative staff and have less access to training courses related to COVID-19, who reported that they did not work at the hospital and had a lower level of knowledge and attitude related to COVID-19. Because of the important role of educators in the education system, this study is expected to help education and health authorities implement suitable interventions to fill the gaps in practices between educators.Keywords: COVID-19, knowledge, attitude, practice, educator, Vietnam

Soil is contaminated with salinity, which inhibits plant growth and development and reduces crop yields. The DREB (dehydration responsive element binding protein) gene responds to salt stresses through enhanced transcriptional expression and activation of genes involved in plant salinity resistance. In this study, we present the results of the analysis of the expression of the GmDREB6 transgene, a gene that encodes the soybean DREB6 transcription factor, regulating the transcription of the NtP5CS and NtCLC genes in transgenic tobacco under salt stress conditions. The transcription of GmDREB6, NtP5CS, and NtCLC in transgenic tobacco lines was confirmed by qRT-PCR. Under salt stress conditions, the GmDREB6 gene transcription levels in the transgenic tobacco lines L1 and L9 had increased from 2.40- to 3.22- fold compared with the condition without salinity treatment. Two transgenic lines, L1 and L9, had transcription levels of the P5CS gene that had increased from 1.24- to 3.60- fold compared with WT plants. For the NtCLC gene, under salt stress conditions, the transgenic lines had transcription levels that had increased by 3.65–4.54 (fold) compared with WT plants (P

Pham Le An,1,2 Giao Huynh,3 Han Thi Ngoc Nguyen,4 Binh Duong Uyen Pham,5,6 Tuong Vy Nguyen,2 Tam Thao Tuyet Tran,1 Tuan Diep Tran7 1Family Medicine Training Center, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 2Grant and Innovation Center, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 3Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 4Infection Control Department, University Medical Center at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 5Department of Educational Quality Assurance, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 6Department of Social Medical Sciences, Graduate School of Medicine, International University of Health and Welfare, Tokyo, Japan; 7Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VietnamCorrespondence: Tuan Diep TranFaculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang, District 5, Ho Chi Minh City, VietnamTel +84 985598528Email dieptuan@ump.edu.vnGiao HuynhFaculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang st, District 5, Ho Chi Minh City, VietnamTel +84 908608338Email hgiaoytcc@ump.edu.vnBackground: Healthcare students are a force that will aid healthcare workers in responding to the COVID-19 pandemic. This study aims to evaluate the knowledge, attitude, and preventive practices (KAP) towards COVID-19 for this population in Vietnam.Methods: An online-based cross-sectional survey was considered with all students at the University of Medicine and Pharmacy in Ho Chi Minh City (UMP), Vietnam, between June and August 2020. A structured questionnaire was used to assess KAP towards COVID-19 with response having considerable data missing in the areas of KAP being excluded from the analysis. All data were analysed by using STATA 14 software, to determine the factors associated with preventive practices, and a multivariable regression analysis was performed, along with odds ratio (OR) and 95% confidence interval (95% CI).Results: A total of 2351 eligible participants completed the survey, 65.6% of whom were female, and their mean age was 21.9 years old (SD = 2.7). Almost all had sufficient knowledge (86.6%) and good preventive practice (92.8%) towards COVID-19; however, there was also a rather low level of positive attitude recorded, at 68.8%. The multivariable logistic regression analysis showed that the female participants, and the receiving of information from the official websites, reported a significantly higher level of good practice. Besides, students who had a high level of sufficient knowledge and positive attitude towards COVID-19 were more likely to have good preventive practices (All p< 0.001).Conclusion: The findings demonstrated good preventive practice towards COVID-19; however, sufficient knowledge and positive attitude were lower. Therefore, it is an identified requirement to continue with additional education and training strategies to offer a better understanding and positive viewpoint of the pandemic for all students, including healthcare students.Keywords: attitude, COVID-19, knowledge, practice, healthcare students, Vietnam

Clear-cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal cell carcinoma (RCC), and its progression has been linked to chronic inflammation. About 70% of the ccRCC cases are associated with inactivation of the von Hippel–Lindau (VHL) tumor-suppressor gene. However, it is still not clear how mutations in VHL, encoding the substrate-recognition subunit of an E3 ubiquitin ligase that targets the alpha subunit of hypoxia-inducible factor-α (HIFα), can coordinate tissue inflammation and tumorigenesis. We previously generated mice with conditional Vhlh knockout in kidney tubules, which resulted in severe inflammation and fibrosis in addition to hyperplasia and the appearance of transformed clear cells. Interestingly, the endothelial cells (EC), although not subject to genetic manipulation, nonetheless showed profound changes in gene expression that suggest a role in promoting inflammation and tumorigenesis. Oncostatin M (OSM) mediated the interaction between VHL-deficient renal tubule cells and the ECs, and the activated ECs in turn induced macrophage recruitment and polarization. The OSM-dependent microenvironment also promoted metastasis of exogenous tumors. Thus, OSM signaling initiates reconstitution of an inflammatory and tumorigenic microenvironment by VHL-deficient renal tubule cells, which plays a critical role in ccRCC initiation and progression.Significance:A novel mechanism of cross-talk between ECs and VHL-deficient kidney tubules that stimulates inflammation and tumorigenesis is discovered, suggesting OSM could be a potential target for ccRCC intervention.

The symptoms of depression are related to low academic achievement, suicidal ideation and cause emotional sufferings, fundamental impairments which can influence students' abilities to perform essential activities of daily living. This study conducted to examine the relationships between depression and not only academic performance but also family structure. This study used the Beck Depression Inventory-II to survey 1336 students from secondary and high schools in Hue province, Vietnam. The findings of our study showed that there were associations between levels of depression and academic performance. Students with good or excellent academic performance were more likely to increase depression than others. Besides, students who had divorced or separated parents were more likely to increase depression gradually than the others. Context: The symptoms of depression are related to low academic achievement, suicidal ideation and cause emotional sufferings, fundamental impairments which can influence students' abilities to perform essential activities of daily living. Aims: This study conducted to examine the relationships between depression and not only academic performance but also family structure. Methods and Material: This study used the Beck Depression Inventory-II to survey 1336 students from secondary and high schools in Hue province, Vietnam. Results: The findings of our study showed that there were associations between levels of depression and academic performance. Conclusions: Students with good or excellent academic performance were more likely to increase depression than others. Besides, students who had divorced or separated parents were more likely to increase depression gradually than the others.

Giao Huynh,1 Hau Viet Nguyen,2 Lan Y Vo,1 Ngoc Thi Le,3 Han Thi Ngoc Nguyen4 1Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 2Emergency Department, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam; 3Faculty of Medicine, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam; 4Infection Control Department, University Medical Center Ho Chi Minh City, Ho Chi Minh City, VietnamCorrespondence: Hau Viet Nguyen, Emergency Department, University Medical Center Ho Chi Minh City, 215 Hong Bang Street, District 5, Ho Chi Minh City, Vietnam, Tel +84918764092, Email hau.nv@umc.edu.vn Han Thi Ngoc Nguyen, Infection Control Department, University Medical Center Ho Chi Minh City, 201 Nguyen Chi Thanh Street, District 5, Ho Chi Minh City, Vietnam, Tel +84397975519, Email han.ntn2@umc.edu.vnIntroduction: The COVID-19 pandemic has been affecting the lives of millions of people globally. Patients recovering from COVID-19 are facing, not only the symptom of long COVID, but also psychological problems, such as sleep disturbance. This study aims to assess the proportion of COVID-19 recovered adult patients that suffer from insomnia and associated factors in Vietnam.Methods: A cross-sectional study was performed between January and March 2022 among patients who have recovered from a COVID-19 infection. Data were collected based on a self-administered questionnaire that included sociodemographic and standardized questionnaires from the Hospital Anxiety and Depression Scale (HADS), the Perceived stress scale (PSS) and the dependent variable using Insomnia Severity Index (ISI). Multivariable logistic regression was conducted to explore factors associated with the patients’ insomnia disorder.Results: A total of 325 participants were included in this analysis, 34.5% of participants had insomnia. According to multivariable logistic regression, participants who were equal to and over 50 years of age, feeling alienated from others, and were not supported by families or relatives, reported significantly higher levels of insomnia disorders over those aged under 50 years, having closer ties with family and had received support from family or relatives. Besides, respondents who recorded mental health problems that included anxiety, depression and stress were more likely to get insomnia disorders than those without mental health symptoms (OR 2.7, 95% CI 1.1– 6.6) (OR 4.5, 95% CI 2.3– 8.9) (OR 2.3, 95% CI 1.1– 5.3), respectively, all p < 0.05.Conclusion: There was a remarkable rate of COVID-19 recovered patients experiencing insomnia disorders. Older age, alienated relationships and not being supported by families or relatives, as well as had mental health problems, are factors that affected the patients’ insomnia, which showed that these sleep issues need to be screened and managed among adults who have recovered from COVID-19.Keywords: COVID-19, insomnia, recovery, sleep disturbance, Vietnam

Corpus linguistics has attracted growing interest from linguistics, researchers, and language educators. This area is potential for studies in linguistics as well as improvement in language learning. This study aims at investigating how a corpus-based website named https://www.english-corpora.org/coca/ - or COCA - helps improve students' lexical usage in written production. Participants were EFL students from a university using COCA over two months for revising vocabulary in their writing assignments. Data included the measure of textual lexical diversity (MTLD) of the participants' revised assignments and their reflections/reviews on using COCA. Results reveal some positive changes in MTLD values, while participants' feedbacks suggest COCA is useful for gaining knowledge about lexis, and improving the use of collocations, synonyms as well as high-lexis despite some challenges of unfamiliar interface and overwhelming contents. The study implies the feasibility of applying corpora provided that there are sufficient facilities and careful training for learners.

Breast cancer (BC) is the leading type of cancer among women. Findings have revolutionized current knowledge of microRNA (miRNA) in breast tumorigenesis. The seed region of miRNA regulates the process of gene expression negatively. The presence of SNPs in the seed regions of miRNA dramatically alters the mature miRNA function. Additionally, SNPs in the out-seed region of miRNAs have a significant impact on miRNA targeting. This study focuses on the in silico analysis procedure of mature miRNA SNPs and their impact on BC risk. The database annotated SNPs on mature miRNAs was used. Also, target gene alterations, miRNAs function in BC, and the interaction of miRNAs with targets were predicted. A list of 101 SNPs in 100 miRNAs with functional targets in BC was indicated. Under the SNPs allele variation, 10 miRNAs changed function, 6 miRNAs lost targets, 15 miRNAs gained targets, 48 onco-miRNAs remained unchanged, and 21 tumor suppressor miRNAs remained unchanged. At last, a list of 89 SNPs, which alter miRNA function and miRNA-mRNA interaction, were shown to be potentially associated with BC risk. This research theoretically generated a list of possible causative SNPs in the mature miRNA gene that might be used in future BC management studies.

Purpose: Improving solubility and antibacterial efficiency of cephalothin by using silica-containing redox nanoparticle (siRNP) as a system to encapsulate and deliver this hydrophobic antibiotic. Methods: siRNP was synthesized by assembling amphiphilic block copolymers possessing a reactive oxygen species scavenging nitroxide radical and drug absorptive silica moieties in a hydrophobic side chain. Cephalothin, a hydrophobic antibiotic, was encapsulated into siRNP (cephalothin@siRNP) by mixing and dialysis methods. Antibacterial activity of cephalothin@siRNP against Staphylococcus aureus (S. aureus) và Escherichia coli (E. coli) was evaluated by the agar diffusion method. Results: The average size of siRNP and cephalothin@siRNP was 43.83 nm and 50.15 nm, respectively. After encapsulation in siRNP, the solubility of cephalothin was improved compared to cephalothin in an aqueous solution. The result showed that in vitro antibacterial activities of cephalothin and cephalothin@siRNP had no statistical difference after 24 h incubation on agar plates on both S. aureus and E. coli. However, after an extended incubation time, regrowth of E. coli colonies in the inhibitory zone was found in cephalothin treated plate. Interestingly, E. coli regrowth was significantly reduced in plates treated with cephalothin@siRNP. Conclusion: In this study, siRNP successfully encapsulated cephalothin and enhanced the solubility of this drug. The antibacterial activity of cephalothin is prolonged when encapsulated in siRNP, which suppressed the reccurrence of E. coli colonies. Cephalothin@siRNP has the potential to inhibit antibiotic resistance.

Mobile devices (e.g., smartphones and tablets) are spreading globally, along with decreasing prices and increasing support utilities with the characteristics of availability, flexibility, portability, individuality, connectivity, and social interactivity. The rise of mobile devices/ technologies in school inspired educational researchers to introduce the term “mobile learning” to push the boundaries of traditional pedagogy. This study was a systematic review of 52 articles related to mobile learning in mathematics education in 2008-2021. It answered the questions about distribution, major research purposes, approaches, methods. The articles for review were chosen using a three-stage methodology: read, select criteria, and summarize. This review study of mobile learning presents findings, which highlighted gaps in existing literature on the topic and has provided insights, can become a platform and guidance for researchers, educators, and policy makers for future research.

Even though community empowerment is a crucial component of sustainable tourism, true community empowerment is in fact hard to achieve and still eludes many countries. Few studies have looked at fa...

PurposeThis paper presents the impact of the COVID-19 pandemic on Vietnam's tourism industry to propose appropriate recovery strategies in the future.Design/methodology/approachThis study uses a combination of research methods. Data were collected from the Ministry of Culture, Sports and Tourism, General Statistics Office, Vietnam National Administration of Tourism and Ministry of Health. Non-parametric statistical methods were applied to analyze the differences between epidemic and non-epidemic periods and find correlations between the number of infections and data related to the performance of the tourism industry. In-depth interviews with 20 people linked to tourism activities were conducted to analyze the impacts and propose strategies for future recovery.FindingsThe results demonstrate the severe impact of the pandemic on Vietnam's tourism industry based on a decrease in the number of visitors, business activities, revenue and employment rate. Therefore, to recover tourism – Vietnam's key economic sector in the future – developing reasonable strategies to build a safe tourism environment, building a sustainable tourist market, diversifying and improving tourism high-quality tourism products, marketing, human resources, digital transformation and sustainable tourism are necessary, along with the development trend of the industry after COVID-19.Originality/valueThis paper synchronously and systematically presents the effects of COVID-19 on Vietnam's tourism industry based on official data. Strategies are proposed to handle these effects on a reliable scientific basis. This study can be considered a valuable reference for researchers and managers of tourism in developing countries, such as Vietnam.

Asymptomatic transmission was found to be the Achilles' heel of the symptom-based screening strategy, necessitating the implementation of mass testing to efficiently contain the transmission of COVID-19 pandemic. However, the global shortage of molecular reagents and the low throughput of available realtime PCR facilities were major limiting factors.A novel semi-nested and heptaplex (7-plex) RT-PCR assay with melting analysis for detection of SARS-CoV-2 RNA has been established for either individual testing or 96-sample pooled testing. The complex melting spectrum collected from the heptaplex RT-PCR amplicons was interpreted with the support of an artificial intelligence algorithm for the detection of SARS-CoV-2 RNA. The analytical and clinical performance of the semi-nested RT-PCR assay was evaluated using RNAs synthesized in-vitro and those isolated from nasopharyngeal samples.The LOD of the assay for individual testing was estimated to be 7.2 copies/reaction. Clinical performance evaluation indicated a sensitivity of 100% (95% CI: 97.83-100) and a specificity of 99.87% (95% CI: 99.55-99.98). More importantly, the assay supports a breakthrough sample pooling method, which makes possible parallel screening of up to 96 samples in one real-time PCR well without loss of sensitivity. As a result, up to 8,820 individual pre-amplified samples could be screened for SARS-CoV-2 within each 96-well plate of realtime PCR using the pooled testing procedure.The novel semi-nested RT-PCR assay provides a solution for highly multiplex (7-plex) detection of SARS-CoV-2 and enables 96-sample pooled detection for increase of testing capacity. .

Methane is considered the carbon source with the highest potential in industrial biotechnology because of its abundance and sustainability. The biological conversion of methane into chemicals or fuels can not only reduce greenhouse gas emissions, but can also substitute edible substrates used in biorefineries. Methanotrophs that can utilize methane as the sole energy and carbon source play a significant role in the ecology of methane. Studies on metabolically-engineered methanotrophs have attracted extensive attention in recent years. In this chapter, the approaches and strategies of methanotrophic cell factory construction are summarized based on synthetic biology tools, systematic manipulation, metabolic modeling, and carbon flux enhancement. Finally, the challenges and opportunities for methane bioconversion by methanotrophs are discussed based on industrial applications.

Objectives: We assessed the factors relating to the prevention of the Novel Coronavirus Disease (COVID-19) for students at the University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam. Methods: A cross-sectional study was performed in February and March 2020. A 21 item self-administered questionnaire on the knowledge, attitude, and practices regarding COVID-19 was collected from students of the first to the sixth year using the strategy of simple random sampling. The aim was to establish factors that relate to practices using Odds ratio (OR) and 95% confidence interval (95% CI) which were estimated by the logistic regression model, p-value

BackgroundUnintentional injuries have emerged as a significant public health issue in low- and middle-income countries (LMIC), especially in Vietnam, where there is a poor quality of care for trauma. A scarcity of formal and informal training opportunities contributes to a lack of structure for treating trauma in Vietnam. A collaborative trauma education project by the JW LEE Center for Global Medicine in South Korea and the Military Hospital 175 in Vietnam was implemented to enhance trauma care capacity among medical staff across Ho Chi Minh City in 2018. We aimed to evaluate a part of the trauma education project, a one-day workshop that targeted improving diagnostic and surgical skills among the medical staff (physicians and nurses).MethodsA one-day workshop was offered to medical staff across Ho Chi Minh City, Vietnam in 2018. The workshop was implemented to enhance the trauma care knowledge of providers and to provide practical and applicable diagnostic and surgical skills. To evaluate the workshop outcomes, we utilized a mixed-methods survey data. All participants (n = 27) voluntarily completed the post-workshop questionnaire. Quality of contents, satisfaction with teaching skills, and perceived benefit were used as outcomes of the workshop, measured by 5-point Likert scales (score: 1–5). Descriptive statistics were performed, and open-ended questions were analyzed by recurring themes.ResultsThe results from the post-workshop questionnaire demonstrated that the participants were highly satisfied with the quality of the workshop contents (mean = 4.32 standard deviation (SD) = 0.62). The mean score of the satisfaction regarding the teaching skills was 4.19 (SD = 0.61). The mean score of the perceived benefit from the workshop was 4.17 (SD = 0.63). The open-ended questions revealed that the program improved their knowledge in complex orthopedic surgeries neglected prior to training.ConclusionsPositive learning experiences highlighted the need for the continuation of the international collaboration of skill development and capacity building for trauma care in Vietnam and other LMIC.

Time becomes a greatly essential factor and time management skill is more important to students’ lives, study and especially in Research Methodology subject. Realizing that, this research aims to study the relationship between time management and performance on Research Methodology subject, specifically to find out techniques which students use to fulfil in assignments of this subject. Questionnaires including questions related to students’ perspectives on time management skills and the factors affecting the relationship between time management and Research Methodology subject were delivered to sixty senior students. The findingsshow the roles, as well as the effects of time management on assignment fulfilment, were confirmed. Most of the participants agreed that time management skills played an essential role in their ability to completeassignments of the subject. And the study also provides students with some effective time management techniques for their successful study.

This study aims to assess the diagnostic value of high-sensitivity C-reactive protein (hs-CRP), procalcitonin (PCT), and interleukin (IL)-6 in the diagnosis of pneumonia caused by Rhinovirus alone or with bacterial coinfection in Vietnamese children under 5 years of age. A cross-sectional study was conducted on 26 children under 5 years of age with severe pneumonia due to Rhinovirus at the National Pediatric Hospital. IL-6, hs-CRP, and PCT tests were performed. The diagnostic values of PCT, IL-6, and hs-CRP in classifying those with viral alone and those with bacterial coinfection were determined. Of 26 children, 10 children were diagnosed to have bacterial coinfections (38.5%). The optimal cutoff point for PCT was > 2.30 ng/mL (sensitivity 50%, specificity 94%, positive predictive value 83%, and negative predictive value 75%). The optimal cutoff point for hs-CRP was > 1.53 mg/dl (sensitivity 90%, specificity 56%, positive predictive value 56%, and negative predictive value 90%). Finally, the optimal cut-off point for IL-6 was > 441.5 pg/mL (sensitivity 20%, specificity 100%, positive predictive value 100%, and negative predictive value 60%). The accuracy rate of PCT was the highest with 69.2%, followed by hs-CRP with 65.4%. Inflammatory biomarkers such as PCT and hs-CRP were able to distinguish children with severe pneumonia caused by Rhinovirus alone and those with bacterial coinfection.

COVID-19 vaccines are critical tools to manage the current pandemic. The objective of this study is to assess determinants of COVID-19 vaccine hesitancy among parents in Ho Chi Minh City, Vietnam.A cross-sectional study of parents were performed, who had at least one child aged 5-17 years. The data were collected by a self-report questionnaire, which was based, predominately, on the Health Belief Model (HBM), between January 21 and 20 April 2021. The main outcome of this study aims to investigate the self-reported parental COVID-19 vaccine hesitancy for their children that has been approved by health authorities in Vietnam.A total of 1,015 parents completed the survey. Parental COVID-19 Vaccine Hesitancy for their children (26.2%) was decreased with blue-collar workers, intended to get vaccinated themselves, indicated sufficient knowledge toward COVID-19, and their older children reported having comorbidities. In the HBM structure, the barriers were positively related to parents' hesitancy to vaccinate their children, whilst perceived susceptibility and severity to illness, benefits of vaccination, and cues to action were less likely to cause a refusal of a vaccination for their children (all p 0.05). The reasons for vaccine hesitancy included, predominately, concerns about side effects (81.6%), and vaccine safety (76.3%).The findings show that almost a quarter of the study population are hesitant to vaccinate their children. Factors were associated with parental vaccination hesitancy for their children include sufficient knowledge of the COVID-19, older children and those with chronic conditions, and domains of HBM like the perception of susceptibility and severity to illness, benefit and barriers of vaccination, and cues to action. These will contribute to make planning in health communication strategies for the upcoming vaccination campaigns, as well as managing the pandemic.