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101. Renal effects of guideline‐directed medical therapies in heart failure: a consensus document from the Heart Failure Association of the European Society of Cardiology

Author

Mullens, Wilfried, primary, Martens, Pieter, additional, Testani, Jeffrey M., additional, Tang, W.H. Wilson, additional, Skouri, Hadi, additional, Verbrugge, Frederik H., additional, Fudim, Marat, additional, Iacoviello, Massimo, additional, Franke, Jennifer, additional, Flammer, Andreas J., additional, Palazzuoli, Alberto, additional, Barragan, Paola Morejon, additional, Thum, Thomas, additional, Marcos, Marta Cobo, additional, Miró, Òscar, additional, Rossignol, Patrick, additional, Metra, Marco, additional, Lassus, Johan, additional, Orso, Francesco, additional, Jankowska, Ewa A., additional, Chioncel, Ovidiu, additional, Milicic, Davor, additional, Hill, Loreena, additional, Seferovic, Petar, additional, Rosano, Giuseppe, additional, Coats, Andrew, additional, and Damman, Kevin, additional

Published
2022
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103. Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy

Author

Baker, Megan L, primary, Yamamoto, Yu, additional, Perazella, Mark A, additional, Dizman, Nazli, additional, Shirali, Anushree C, additional, Hafez, Navid, additional, Weinstein, Jason, additional, Simonov, Michael, additional, Testani, Jeffrey M, additional, Kluger, Harriet M, additional, Cantley, Lloyd G, additional, Parikh, Chirag R, additional, Wilson, F Perry, additional, and Moledina, Dennis G, additional

Published
2022
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105. Changes in inferior vena cava area represent a more sensitive metric than changes in filling pressures during experimental manipulation of intravascular volume and tone

Author

Ivey‐Miranda, Juan B., primary, Wetterling, Friedrich, additional, Gaul, Robert, additional, Sheridan, Stephen, additional, Asher, Jennifer L., additional, Rao, Veena S., additional, Maulion, Christopher, additional, Mahoney, Devin, additional, Mebazaa, Alexandre, additional, Gray, Alastair P., additional, Burkhoff, Daniel, additional, Cowie, Martin R., additional, Cox, Zachary L., additional, Butler, Javed, additional, Fudim, Marat, additional, McDonald, Kenneth, additional, Damman, Kevin, additional, Borlaug, Barry A., additional, and Testani, Jeffrey M., additional

Published
2022
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112. FGF-23 (Fibroblast Growth Factor-23) and Cardiorenal Interactions

Author

Ivey-Miranda, Juan B., primary, Stewart, Brendan, additional, Cox, Zachary L., additional, McCallum, Wendy, additional, Maulion, Christopher, additional, Gleason, Olyvia, additional, Meegan, Grace, additional, Amatruda, Jonathan G., additional, Moreno-Villagomez, Julieta, additional, Mahoney, Devin, additional, Turner, Jeffrey M., additional, Wilson, F. Perry, additional, Estrella, Michelle M., additional, Shlipak, Michael G., additional, Rao, Veena S., additional, and Testani, Jeffrey M., additional

Published
2021
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113. Renal negative pressure treatment as a novel therapy for heart failure-induced renal dysfunction

Author

Rao, Veena S., primary, Maulion, Christopher, additional, Asher, Jennifer L., additional, Ivey-Miranda, Juan B., additional, Cox, Zachary L., additional, Moreno-Villagomez, Julieta, additional, Mahoney, Devin, additional, Turner, Jeffrey M., additional, Wilson, F. Perry, additional, Wilcox, Christopher S., additional, and Testani, Jeffrey M., additional

Published
2021
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114. Use of diuretics and outcomes in patients with type 2 diabetes: findings from the EMPA-REG OUTCOME trial

Author

Pellicori, Pierpaolo, Fitchett, David, Kosiborod, Mihkail N., Ofstad, Anne P., Seman, Leo, Zinman, Bernard, Zwiener, Isabella, Wanner, Christoph, George, Jyothis, Inzucchi, Silvio E., Testani, Jeffrey M., and Cleland, John G.F.

Abstract

Background: \ud Loop diuretics (LD) relieve symptoms and signs of congestion due to heart failure (HF), but many patients prescribed LD do not have such a diagnosis.\ud \ud Aims and methods: \ud We studied the relationship between HF diagnosis, use of LD, and outcomes in four patient subgroups with type-2 diabetes mellitus (T2DM) in EMPA-REG OUTCOME; [i) investigator-reported HF on LD, ii) investigator-reported HF not on LD, iii] no HF on LD, and iv) no HF and not on LD], and assessed their risk of CV events.\ud \ud Results: \ud Of 7,020 participants, at baseline, 706 (10%) had a diagnosis of HF, of whom 334 were prescribed LD. However, 755 (11%) patients who did not have a diagnosis of HF were prescribed LD. Compared to those with neither HF nor prescribed LD (reference group; placebo), those with both HF and receiving LD had the highest rates for all-cause (hazard ratio [HR] [95% CI]: 3.19 [2.03-5.01]) and CV mortality (3.83 [2.28-6.44]), and HF hospitalisations (HHF) (9.51 [5.61-16.14]). Patients without HF but prescribed LD had higher rates for all three outcomes (1.62 [1.10-2.39]); 1.97 [1.26-3.08]); 3.20 [1.90-5.39]), which were similar to patients with HF who were not receiving LD (1.42 [0.78-2.57]; 1.56 [0.78-3.11]; 3.00 [1.40-6.40)]). Empagliflozin had similar benefits regardless of subgroup (p for interaction >0.1 for all outcomes).\ud \ud Conclusion: \ud Patients with T2DM prescribed LD are at greater risk of CV events even if they are not reported to have HF; this might reflect under-diagnosis. Empagliflozin was similarly effective in all subgroups investigated.

Published
2021

118. Compensatory post-diuretic renal sodium reabsorption is not a dominant mechanism of diuretic resistance in acute heart failure

Author

Cox, Zachary L, primary, Rao, Veena S, additional, Ivey-Miranda, Juan B, additional, Moreno-Villagomez, Julieta, additional, Mahoney, Devin, additional, Ponikowski, Piotr, additional, Biegus, Jan, additional, Turner, Jeffrey M, additional, Maulion, Christopher, additional, Bellumkonda, Lavanya, additional, Asher, Jennifer L, additional, Parise, Helen, additional, Wilson, Perry F, additional, Ellison, David H, additional, Wilcox, Christopher S, additional, and Testani, Jeffrey M, additional

Published
2021
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122. Early urine electrolyte patterns in patients with acute heart failure

Author

Collins, Sean P., Jenkins, Cathy A., Baughman, Adrienne, Miller, Karen F., Storrow, Alan B., Han, Jin H., Brown, Nancy J., Liu, Dandan, Luther, James M., McNaughton, Candace D., Self, Wesley H., Peng, Dungeng, Testani, Jeffrey M., and Lindenfeld, JoAnn

Subjects
Heart Failure, Male, Emergency department, Sodium, Worsening heart failure, Acute heart failure, Pilot Projects, Stroke Volume, Middle Aged, Prognosis, Original Research Articles, Acute Disease, Disease Progression, Diuretic resistance, Humans, Female, Original Research Article, Prospective Studies, Diuretics, Urine electrolytes, Biomarkers, Aged, Follow-Up Studies
Abstract

Aims We conducted a prospective study of emergency department (ED) patients with acute heart failure (AHF) to determine if worsening HF (WHF) could be predicted based on urinary electrolytes during the first 1–2 h of ED care. Loop diuretics are standard therapy for AHF patients. A subset of patients hospitalized for AHF will develop a blunted natriuretic response to loop diuretics, termed diuretic resistance, which often leads to WHF. Early detection of diuretic resistance could facilitate escalation of therapy and prevention of WHF. Methods and results Patients were eligible if they had an ED AHF diagnosis, had not yet received intravenous diuretics, had a systolic blood pressure > 90 mmHg, and were not on dialysis. Urine electrolytes and urine output were collected at 1, 2, 4, and 6 h after diuretic administration. Worsening HF was defined as clinically persistent or WHF requiring escalation of diuretics or administration of intravenous vasoactives after the ED stay. Of the 61 patients who qualified in this pilot study, there were 10 (16.3%) patients who fulfilled our definition of WHF. At 1 h after diuretic administration, patients who developed WHF were more likely to have low urinary sodium (9.5 vs. 43.0 mmol; P

Published
2018

127. Reply

Author

Rao, Veena S., primary, Ivey-Miranda, Juan B., additional, Cox, Zachary L., additional, and Testani, Jeffrey M., additional

Published
2021
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128. Pragmatic Design of Randomized Clinical Trials for Heart Failure

Author

Greene, Stephen J., primary, Velazquez, Eric J., additional, Anstrom, Kevin J., additional, Eisenstein, Eric L., additional, Sapp, Shelly, additional, Morgan, Shelby, additional, Harding, Tina, additional, Sachdev, Vandana, additional, Ketema, Fassil, additional, Kim, Dong-Yun, additional, Desvigne-Nickens, Patrice, additional, Pitt, Bertram, additional, Mentz, Robert J., additional, Adams, Kirkwood, additional, Long, Tammy, additional, Bhatt, Kunal, additional, Walker, Brandon, additional, DeWald, Tracy, additional, Biever, Kim, additional, Axsom, Kelly, additional, Acosta, Ariana, additional, Murthy, Sandhya, additional, Camilo, Angeline, additional, Rich, Jonathan D., additional, Martinez, Leslie, additional, Testani, Jeffrey M., additional, Tainsh, Jennifer, additional, Smith, Bryan, additional, Bennett, Amy, additional, Vader, Justin, additional, Stilinovic, Stephanie, additional, McCulloch, Michael, additional, Musso, Iris, additional, Skopicki, Hal, additional, Caikauskaite, Indre, additional, Psotka, Mitchell A., additional, Freiler, Allen, additional, Heroux, Alain, additional, Kartje, Carol, additional, Lala-Trindade, Anuradha, additional, Julien, Lovelyne, additional, Stevens, Gerin, additional, Leppla, Keriann, additional, Tang, Wilson, additional, Fonk, Teresa, additional, Lev, Yair, additional, Fizgerald, Kathleen, additional, William, Preethi, additional, Stroster, John, additional, Eberly, Arthur, additional, Workman, Celeste, additional, Gottlieb, Stephen, additional, Bowers-Lash, Mary, additional, Haught, Walter Herbert, additional, Abath, Cynthia, additional, Grafton, Gillian, additional, Neaton, Kelsey, additional, Larned, Joshua, additional, Ortiz, Mara-Li, additional, Tejwani, Lokesh, additional, Villalta, Tara, additional, Mody, Freny, additional, Strugatsky, Svetlana, additional, Krim, Selim, additional, Washington, Katasha, additional, Robinson, Monique, additional, Norton, Nadine, additional, Smart, Frank, additional, Worsham, Emily, additional, Fang, James, additional, Goldstein, Joe, additional, Dunlap, Stephanie, additional, Starnes, Nancy, additional, Adler, Alexander, additional, Theodorof, Virginia, additional, Bell, Adrian, additional, Kondramashin, Aleksey, additional, Banerjee, Dipanjan, additional, Yee, Michael, additional, Ruiz-Duque, Ernesto, additional, Larew, Cynthia, additional, Mizyed, Ahmad, additional, Sawaya, Kara, additional, Friedman, Dennis, additional, Rele, Shilpa, additional, Rommel, John, additional, Burkhart, Janet, additional, Arhinful, Justice, additional, Atkinson, Sam, additional, Goyal, Parag, additional, Samdani, Nidha, additional, Hall, Michael, additional, Watson, Connie, additional, Hummel, Scott, additional, Wells, Joanna, additional, Shetty, Sanjay, additional, White, Jackie, additional, Haas, Donald, additional, Marchand, Colleen, additional, Vilaro, Juan, additional, Osman, Alfaroug, additional, Alexy, Tamas, additional, Dicken, Julie, additional, Guglin, Maya, additional, Willig, Meghan, additional, Ferguson, Andrew, additional, Peabody, Mark, additional, Herre, John, additional, McMichael, Brittany, additional, Clark, John, additional, Britton, Nancy, additional, Ambrosy, Andrew P., additional, Tan, Thida, additional, Heitner, John, additional, Meykler, Marcella, additional, Meadows, Judith, additional, and Halliday, Janet, additional

Published
2021
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129. The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study

Author

Moledina, Dennis G., primary, Simonov, Michael, additional, Yamamoto, Yu, additional, Alausa, Jameel, additional, Arora, Tanima, additional, Biswas, Aditya, additional, Cantley, Lloyd G., additional, Ghazi, Lama, additional, Greenberg, Jason H., additional, Hinchcliff, Monique, additional, Huang, Chenxi, additional, Mansour, Sherry G., additional, Martin, Melissa, additional, Peixoto, Aldo, additional, Schulz, Wade, additional, Subair, Labeebah, additional, Testani, Jeffrey M., additional, Ugwuowo, Ugochukwu, additional, Young, Patrick, additional, and Wilson, F. Perry, additional

Published
2021
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132. Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure

Author

Bhatt, Deepak L., primary, Szarek, Michael, additional, Steg, P. Gabriel, additional, Cannon, Christopher P., additional, Leiter, Lawrence A., additional, McGuire, Darren K., additional, Lewis, Julia B., additional, Riddle, Matthew C., additional, Voors, Adriaan A., additional, Metra, Marco, additional, Lund, Lars H., additional, Komajda, Michel, additional, Testani, Jeffrey M., additional, Wilcox, Christopher S., additional, Ponikowski, Piotr, additional, Lopes, Renato D., additional, Verma, Subodh, additional, Lapuerta, Pablo, additional, and Pitt, Bertram, additional

Published
2021
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133. Acute Declines in Kidney Function in the Context of Decongestion in Patients with Acute Decompensated Heart Failure

Author

McCallum, Wendy, Tighiouart, Hocine, Testani, Jeffrey M., Griffin, Matthew, Konstam, Marvin A., Udelson, James E., and Sarnak, Mark J.

Subjects
Heart Failure, Male, Stroke Volume, Acute Kidney Injury, Middle Aged, Kidney, Prognosis, Article, Natriuretic Peptide, Brain, Tolvaptan, Humans, Female, Antidiuretic Hormone Receptor Antagonists, Biomarkers, Aged, Glomerular Filtration Rate
Abstract

This study aimed to examine whether incorporation of a comprehensive set of measures of decongestion modifies the association of acute declines in kidney function with outcomes.In-hospital acute declines in kidney function occur in approximately 20% to 30% of patients admitted with acute decompensated heart failure (ADHF) and may be associated with adverse outcomes.Using data from EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan), we used multivariable Cox regression models to evaluate the association between in-hospital changes in estimated glomerular filtration rate (eGFR) with death and a composite outcome of cardiovascular death and hospitalization for heart failure. We evaluated eGFR declines within the context of changes in markers of volume overload including b-type natriuretic peptide (BNP), N-terminal prohormone of B-type natriuretic peptide (NT-proBNP), and weight, as well as changes in measures of hemoconcentration including hematocrit, albumin, and total protein.Among 3,715 patients over a median follow-up of 9.9 months, every 30% decline in eGFR was associated with higher risk of both death (hazard ratio [HR]: 1.19; 95% confidence interval [CI]: 1.07 to 1.31) and the composite outcome (HR: 1.09; 95% CI: 1.01 to 1.18) in adjusted models. The acute decline in eGFR was no longer associated with higher risk of either outcome as long as there was evidence of decongestion, either by declines in BNP, NT-proBNP, or weight or by increases in hematocrit, albumin or total protein. Interaction testing between decline in eGFR and changes in hematocrit, albumin, and total protein was statistically significant (p interaction of 0.01 for death and p interaction of ≤0.01 for composite for all 3 biomarkers). Interaction between change in eGFR and changes in BNP (p interaction = 0.07 for death; p interaction = 0.08 for composite), NT-proBNP (p interaction = 0.15 for death; p interaction = 0.18 for composite) and weight (p interaction = 0.13 for death; p interaction = 0.19 for composite) did not meet statistical significance.Overall, acute declines in eGFR are associated with adverse outcomes, with evidence of modification by changes in markers of decongestion, suggesting that they are no longer associated with adverse outcomes if these markers are concomitantly improving.

Published
2020

135. Real-Time Prediction of Acute Kidney Injury in Hospitalized Adults: Implementation and Proof of Concept

Author

Ugwuowo, Ugochukwu, primary, Yamamoto, Yu, additional, Arora, Tanima, additional, Saran, Ishan, additional, Partridge, Caitlin, additional, Biswas, Aditya, additional, Martin, Melissa, additional, Moledina, Dennis G., additional, Greenberg, Jason H., additional, Simonov, Michael, additional, Mansour, Sherry G., additional, Vela, Ricardo, additional, Testani, Jeffrey M., additional, Rao, Veena, additional, Rentfro, Keith, additional, Obeid, Wassim, additional, Parikh, Chirag R., additional, and Wilson, F. Perry, additional

Published
2020
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137. Contributors

Author

Abudayyeh, Ala, Adrogué, Horacio J., Ambruso, Sophia L., Anand, Shuchi, Bansal, Amar D., Barratt, Jonathan, Bazeley, Jonathan W., Berns, Jeffrey S., Bjornstad, Petter, Bobart, Shane A., Bomback, Andrew S., Braun, Daniela A., Brewster, Ursula C., Cattran, Daniel C., Chandraker, Anil, Chandran, Sindhu, Chapman, Arlene B., Cherney, David Z., Cohen, Debbie L., Cook, Jared, Cortazar, Frank B., Dad, Taimur, D’Agati, Vivette D., De Vriese, An S., Derebail, Vimal K., DuBose, Thomas D., Jr., Dubrofsky, Lisa, Emmett, Michael, Evenepoel, Pieter, Fairhead, Todd, Ferrey, Antoney J., Fervenza, Fernando C., Finkel, Kevin W., Flood, Ryan P., Födinger, Manuela, Freedman, Barry I., Garcia, Pablo, Garratt, Joanie M., Gelfand, Samantha L., Gilbert, Scott J., Greenberg, Arthur, Gregory, Martin C., Gunning, Samantha, Herlitz, Leal, Hildebrandt, Friedhelm, Hladik, Gerald A., Hladunewich, Michelle A., Hoenig, Melanie P., Hogan, Jonathan, Ikizler, T. Alp, Inker, Lesley A., Ison, Michael G., Juncos, Luis A., Kain, Renate, Kala, Jaya, Kalantar-Zadeh, Kamyar, Kendrick, Jessica, Knauf, Felix, Knoll, Greg, Kopp, Jeffrey B., Kovesdy, Csaba P., Koyner, Jay L., Kruzel-Davila, Etty, Levey, Andrew S., Li, Jian, Linas, Stuart L., Lopez-Ruiz, Arnaldo, Luciano, Randy L., Luyckx, Valerie A., Ma, Lijun, Macedo, Etienne, Madias, Nicolaos E., Mehta, Ankit N., Mehta, Ravindra L., Misra, Madhukar, Morgan, Matthew A., Nast, Cynthia C., Ngamvichchukorn, Tanun, Nolin, Thomas D., O’Hare, Ann, Olaniran, Kabir O., Pantel, Austin R., Peixoto, Aldo J., Perazella, Mark A., Perera, Dinushi S., Perl, Jeffrey, Pfau, Anja, Provenzano, Laura Ferreira, Quarles, L. Darryl, Radhakrishnan, Jai, Rahbari-Oskoui, Frederic F., Rhee, Connie, Rizk, Dana V., Rosenberg, Avi Z., Rosner, Mitchell H., Sahinoz, Melis, Sampogna, Rosemary V., Sanders, Paul W., Sarnak, Mark J., Scheinman, Steven J., Schell, Jane O., Schnaper, H. William, Schrauben, Sarah, Schreiber, Brittany L., Sethi, Sanjeev, Shah, Nikhil, Shen, Wen, Shirali, Anushree C., Sise, Meghan E., Soi, Vivek, Strohbehn, Ian A., Sunder-Plassmann, Gere, Sutherland, Richard W., Sy, John E., Szerlip, Harold M., Tangren, Jessica, Tangri, Navdeep, Testani, Jeffrey M., Thurman, Joshua M., Townsend, Raymond R., Trachtman, Howard, Turner, Jeffrey M., Velez, Juan Carlos Q., Verbalis, Joseph G., Vincenti, Flavio G., Vivarelli, Marina, Warady, Bradley A., Weidemann, Darcy K., Weiner, Daniel E., Wilcox, Christopher S., Wish, Jay B., Yee, Jerry, and Yeo, See Cheng

Published
2023
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145. Mechanisms of Diuretic Resistance Study: design and rationale

Author

Cox, Zachary L., primary, Fleming, James, additional, Ivey‐Miranda, Juan, additional, Griffin, Matthew, additional, Mahoney, Devin, additional, Jackson, Keyanna, additional, Hodson, Daniel Z., additional, Thomas, Daniel, additional, Gomez, Nicole, additional, Rao, Veena S., additional, and Testani, Jeffrey M., additional

Published
2020
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147. A Time-Updated, Parsimonious Model to Predict AKI in Hospitalized Children

Author

Sandokji, Ibrahim, primary, Yamamoto, Yu, additional, Biswas, Aditya, additional, Arora, Tanima, additional, Ugwuowo, Ugochukwu, additional, Simonov, Michael, additional, Saran, Ishan, additional, Martin, Melissa, additional, Testani, Jeffrey M., additional, Mansour, Sherry, additional, Moledina, Dennis G., additional, Greenberg, Jason H., additional, and Wilson, F. Perry, additional

Published
2020
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150. Evaluation of kidney function throughout the heart failure trajectory – a position statement from the Heart Failure Association of the European Society of Cardiology

Author

Mullens, Wilfried, primary, Damman, Kevin, additional, Testani, Jeffrey M., additional, Martens, Pieter, additional, Mueller, Christian, additional, Lassus, Johan, additional, Tang, W.H. Wilson, additional, Skouri, Hadi, additional, Verbrugge, Frederik H., additional, Orso, Francesco, additional, Hill, Loreena, additional, Ural, Dilek, additional, Lainscak, Mitcha, additional, Rossignol, Patrick, additional, Metra, Marco, additional, Mebazaa, Alexandre, additional, Seferovic, Petar, additional, Ruschitzka, Frank, additional, and Coats, Andrew, additional

Published
2020
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