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104. Biologically Effective Dose and the Tumor Control in Early-Stage Non-Small Cell Lung Cancer Treated with Stereotactic Body Radiation Therapy: Comparison of Isocenter- and PTV-Based Prescription Methods

Author

Ikawa, T., primary, Wada, K., additional, Kanayama, N., additional, Hirata, T., additional, Isono, M., additional, Ohira, S., additional, Ueda, Y., additional, Miyazaki, M., additional, Morimoto, M., additional, Konishi, K., additional, and Teshima, T., additional

Published
2018
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105. A Phase II Study of Two-Step Intensity Modulated Radiation Therapy (IMRT) with Chemotherapy for Loco-Regionally Advanced Nasopharyngeal Cancer (NPC) (JCOG1015)

Author

Nishimura, Y., primary, Kodaira, T., additional, Ito, Y., additional, Tsuchiya, K., additional, Murakami, Y., additional, Saitoh, J.I., additional, Akimoto, T., additional, Nakata, K., additional, Yoshimura, M., additional, Teshima, T., additional, Toshiyasu, T., additional, Ota, Y., additional, Ishikawa, K., additional, Shimizu, H., additional, Minemura, T., additional, Ishikura, S., additional, Shibata, T., additional, Nakamura, K., additional, and Hiraoka, M., additional

Published
2018
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111. Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Author

Mathew, N.R., Baumgartner, F., Braun, L., O'Sullivan, D., Thomas, S., Waterhouse, M., Muller, T.A., Hanke, K., Taromi, S., Apostolova, P., Illert, A.L., Melchinger, W., Duquesne, S., Schmitt-Graeff, A., Osswald, L., Yan, K.L., Weber, A, Tugues, S., Spath, S., Pfeifer, D., Follo, M., Claus, R., Lubbert, M., Rummelt, C., Bertz, H., Wasch, R., Haag, J., Schmidts, A., Schultheiss, M., Bettinger, D., Thimme, R., Ullrich, E., Tanriver, Y., Vuong, G.L., Arnold, R., Hemmati, P., Wolf, D., Ditschkowski, M., Jilg, C., Wilhelm, K., Leiber, C., Gerull, S., Halter, J., Lengerke, C., Pabst, T., Schroeder, T., Kobbe, G., Rosler, W., Doostkam, S., Meckel, S., Stabla, K., Metzelder, S.K., Halbach, S., Brummer, T., Hu, Z, Dengjel, J., Hackanson, B., Schmid, C., Holtick, U., Scheid, C., Spyridonidis, A., Stolzel, F., Ordemann, R., Muller, L.P., Sicre-de-Fontbrune, F., Ihorst, G., Kuball, J., Ehlert, J.E., Feger, D., Wagner, E.M., Cahn, J.Y., Schnell, J., Kuchenbauer, F., Bunjes, D., Chakraverty, R., Richardson, S., Gill, S., Kroger, N., Ayuk, F., Vago, L., Ciceri, F., Muller, A.M., Kondo, T., Teshima, T., Klaeger, S., Kuster, B., Kim, D.D.H., Weisdorf, D., Velden, W.J. van der, Dorfel, D., Bethge, W., Hilgendorf, I., Hochhaus, A., Andrieux, G., Borries, M., Busch, H., Magenau, J., Reddy, P., Labopin, M., Antin, J.H., et al., Mathew, N.R., Baumgartner, F., Braun, L., O'Sullivan, D., Thomas, S., Waterhouse, M., Muller, T.A., Hanke, K., Taromi, S., Apostolova, P., Illert, A.L., Melchinger, W., Duquesne, S., Schmitt-Graeff, A., Osswald, L., Yan, K.L., Weber, A, Tugues, S., Spath, S., Pfeifer, D., Follo, M., Claus, R., Lubbert, M., Rummelt, C., Bertz, H., Wasch, R., Haag, J., Schmidts, A., Schultheiss, M., Bettinger, D., Thimme, R., Ullrich, E., Tanriver, Y., Vuong, G.L., Arnold, R., Hemmati, P., Wolf, D., Ditschkowski, M., Jilg, C., Wilhelm, K., Leiber, C., Gerull, S., Halter, J., Lengerke, C., Pabst, T., Schroeder, T., Kobbe, G., Rosler, W., Doostkam, S., Meckel, S., Stabla, K., Metzelder, S.K., Halbach, S., Brummer, T., Hu, Z, Dengjel, J., Hackanson, B., Schmid, C., Holtick, U., Scheid, C., Spyridonidis, A., Stolzel, F., Ordemann, R., Muller, L.P., Sicre-de-Fontbrune, F., Ihorst, G., Kuball, J., Ehlert, J.E., Feger, D., Wagner, E.M., Cahn, J.Y., Schnell, J., Kuchenbauer, F., Bunjes, D., Chakraverty, R., Richardson, S., Gill, S., Kroger, N., Ayuk, F., Vago, L., Ciceri, F., Muller, A.M., Kondo, T., Teshima, T., Klaeger, S., Kuster, B., Kim, D.D.H., Weisdorf, D., Velden, W.J. van der, Dorfel, D., Bethge, W., Hilgendorf, I., Hochhaus, A., Andrieux, G., Borries, M., Busch, H., Magenau, J., Reddy, P., Labopin, M., and Antin, J.H., et al.

Abstract

Contains fulltext : 190745.pdf (publisher's version ) (Closed access), Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication (ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after allogeneic hematopoietic cell transplantation (allo-HCT) have a 1-year survival rate below 20%. We observed that sorafenib, a multitargeted tyrosine kinase inhibitor, increased IL-15 production by FLT3-ITD(+) leukemia cells. This synergized with the allogeneic CD8(+) T cell response, leading to long-term survival in six mouse models of FLT3-ITD(+) AML. Sorafenib-related IL-15 production caused an increase in CD8(+)CD107a(+)IFN-gamma(+) T cells with features of longevity (high levels of Bcl-2 and reduced PD-1 levels), which eradicated leukemia in secondary recipients. Mechanistically, sorafenib reduced expression of the transcription factor ATF4, thereby blocking negative regulation of interferon regulatory factor 7 (IRF7) activation, which enhanced IL-15 transcription. Both IRF7 knockdown and ATF4 overexpression in leukemia cells antagonized sorafenib-induced IL-15 production in vitro. Human FLT3-ITD(+) AML cells obtained from sorafenib responders following sorafenib therapy showed increased levels of IL-15, phosphorylated IRF7, and a transcriptionally active IRF7 chromatin state. The mitochondrial spare respiratory capacity and glycolytic capacity of CD8(+) T cells increased upon sorafenib treatment in sorafenib responders but not in nonresponders. Our findings indicate that the synergism of T cells and sorafenib is mediated via reduced ATF4 expression, causing activation of the IRF7-IL-15 axis in leukemia cells and thereby leading to metabolic reprogramming of leukemia-reactive T cells in humans. Therefore, sorafenib treatment has the potential to contribute to an immune-mediated cure of FLT3-ITD-mutant AML relapse, an otherwise fatal complication after allo-HCT.

Published
2018

112. The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future

Author

Andermann, T. M., Peled, J. U., Ho, C., Reddy, P., Riches, M., Storb, R., Teshima, T., van den Brink, M. R. M., Alousi, A., Balderman, S., Chiusolo, Patrizia, Clark, W. B., Holler, E., Howard, A., Kean, L. S., Koh, A. Y., Mccarthy, P. L., Mccarty, J. M., Mohty, M., Nakamura, R., Rezvani, K., Segal, B. H., Shaw, B. E., Shpall, E. J., Sung, A. D., Weber, D., Whangbo, J., Wingard, J. R., Wood, W. A., Perales, M. -A., Jenq, R. R., Bhatt, A. S., Chiusolo P. (ORCID:0000-0002-1355-1587), Andermann, T. M., Peled, J. U., Ho, C., Reddy, P., Riches, M., Storb, R., Teshima, T., van den Brink, M. R. M., Alousi, A., Balderman, S., Chiusolo, Patrizia, Clark, W. B., Holler, E., Howard, A., Kean, L. S., Koh, A. Y., Mccarthy, P. L., Mccarty, J. M., Mohty, M., Nakamura, R., Rezvani, K., Segal, B. H., Shaw, B. E., Shpall, E. J., Sung, A. D., Weber, D., Whangbo, J., Wingard, J. R., Wood, W. A., Perales, M. -A., Jenq, R. R., Bhatt, A. S., and Chiusolo P. (ORCID:0000-0002-1355-1587)

Abstract

N/A

Published
2018

115. HCV in Lymphoid Neoplasms

Author

Teshima T, Ryo Kikuchi, Yamamoto Y, Matsuoka S, Tsutsumi Y, Naruse H, and Shinichi Ito

Subjects
business.industry, Open access publishing, Hepatitis C virus, medicine, Library science, Rituximab, Lymphoid neoplasms, business, medicine.disease_cause, medicine.disease, Virology, medicine.drug, Non-Hodgkin's lymphoma
Published
2016

123. ACTIVATION OF RHOA-VAV1 SIGNALING IN ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA

Author

Sakata-Yanagimoto, M., primary, Fujisawa, M., additional, Nishizawa, S., additional, Komori, D., additional, Gershon, P., additional, Kiryu, M., additional, Swarna, T., additional, Fukumoto, K., additional, Enami, T., additional, Muratani, M., additional, Yoshida, K., additional, Ogawa, S., additional, Matsue, K., additional, Nakamura, N., additional, Takeuchi, K., additional, Izutsu, K., additional, Teshima, T., additional, Fujimoto, K., additional, Miyoshi, H., additional, Gaulard, P., additional, Ohshima, K., additional, and Chiba, S., additional

Published
2017
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124. A retrospective analysis of the clinical effects of neoadjuvant combination therapy with full-dose gemcitabine and radiation therapy in patients with biliary tract cancer

Author

Kobayashi, S., primary, Tomokuni, A., additional, Gotoh, K., additional, Takahashi, H., additional, Akita, H., additional, Marubashi, S., additional, Yamada, T., additional, Teshima, T., additional, Fukui, K., additional, Fujiwara, Y., additional, and Sakon, M., additional

Published
2017
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127. GvHD after umbilical cord blood transplantation for acute leukemia: an analysis of risk factors and effect on outcomes

Author

Chen, Y-B, primary, Wang, T, additional, Hemmer, M T, additional, Brady, C, additional, Couriel, D R, additional, Alousi, A, additional, Pidala, J, additional, Urbano-Ispizua, A, additional, Choi, S W, additional, Nishihori, T, additional, Teshima, T, additional, Inamoto, Y, additional, Wirk, B, additional, Marks, D I, additional, Abdel-Azim, H, additional, Lehmann, L, additional, Yu, L, additional, Bitan, M, additional, Cairo, M S, additional, Qayed, M, additional, Salit, R, additional, Gale, R P, additional, Martino, R, additional, Jaglowski, S, additional, Bajel, A, additional, Savani, B, additional, Frangoul, H, additional, Lewis, I D, additional, Storek, J, additional, Askar, M, additional, Kharfan-Dabaja, M A, additional, Aljurf, M, additional, Ringden, O, additional, Reshef, R, additional, Olsson, R F, additional, Hashmi, S, additional, Seo, S, additional, Spitzer, T R, additional, MacMillan, M L, additional, Lazaryan, A, additional, Spellman, S R, additional, Arora, M, additional, and Cutler, C S, additional

Published
2016
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128. Low-dose thymoglobulin as second-line treatment for steroid-resistant acute GvHD: an analysis of the JSHCT

Author

Murata, M, primary, Ikegame, K, additional, Morishita, Y, additional, Ogawa, H, additional, Kaida, K, additional, Nakamae, H, additional, Ikeda, T, additional, Nishida, T, additional, Inoue, M, additional, Eto, T, additional, Kubo, K, additional, Sakura, T, additional, Mori, T, additional, Uchida, N, additional, Ashida, T, additional, Matsuhashi, Y, additional, Miyazaki, Y, additional, Ichinohe, T, additional, Atsuta, Y, additional, and Teshima, T, additional

Published
2016
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131. Dose Volume Parameters as Predictors for Radiation-Induced Hypothyroidism After IMRT or VMAT for Head and Neck Squamous Cell Carcinoma: Comparison of the Availability Between Mean Thyroid Dose and Median Thyroid Dose

Author

Hirata, T., primary, Kishi, N., additional, Imai, Y., additional, Kanayama, N., additional, Kawaguchi, Y., additional, Konishi, K., additional, Masaoka, A., additional, Oohira, S., additional, Miyazaki, M., additional, Nishiyama, K., additional, and Teshima, T., additional

Published
2016
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132. A Phase II Study of Intensity Modulated Radiation Therapy (IMRT) with Chemotherapy for Locoregionally Advanced Nasopharyngeal Cancer (NPC) (JCOG1015): Acute Toxicity and Treatment Compliance

Author

Nishimura, Y., primary, Kodaira, T., additional, Ito, Y., additional, Tsuchiya, K., additional, Murakami, Y., additional, Saitoh, J.I., additional, Akimoto, T., additional, Nakata, K., additional, Yoshimura, M., additional, Teshima, T., additional, Toshiyasu, T., additional, Ota, Y., additional, Ishikawa, K., additional, Shimizu, H., additional, Minemura, T., additional, Ishikura, S., additional, Shibata, T., additional, Nakamura, K., additional, and Hiraoka, M., additional

Published
2016
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136. Granulocyte Colony-Stimulating Factor–Mobilized Allogeneic Stem Cell Transplantation Maintains Graft-Versus-Leukemia Effects Through a Perforin-Dependent Pathway While Preventing Graft-Versus-Host Disease

Author

Pan, Lp, Teshima, T., Geoffrey Hill, Bungard, D., Brinson, Ys, Reddy, Vs, Cooke, Kr, and Ferrara, Lm

Subjects
surgical procedures, operative, Immunology, Cell Biology, Hematology, Biochemistry
Abstract

Minimization of graft-versus-host disease (GVHD) with preservation of the graft-versus-leukemia (GVL) effect is a crucial step to improve the overall survival of allogeneic bone marrow transplantation (BMT) for patients with hematological malignancies. We and other investigators have shown that granulocyte colony-stimulating factor (G-CSF)–mobilized allogeneic peripheral stem cell transplantation (PBSCT) reduces the severity of acute GVHD in murine models. In this study, we investigated whether G-CSF–mobilized PBSC maintain their GVL effect in a murine allogeneic transplant model (B6 → B6D2F1). B6 mice (H-2b) were injected subcutaneously with human G-CSF (100 μg/kg/d) for 6 days and their splenocytes were harvested on day 7 as a source of PBSC. G-CSF mobilization dramatically improved transplant survival compared with nonmobilized controls (95% v0%, P < .001). Systemic levels of lipopolysaccharide and tumor necrosis factor- were markedly reduced in recipients of allogeneic G-CSF–mobilized donors, but cytolytic T lymphocyte (CTL) activity against host tumor target cells p815 was retained in those recipients. When leukemia was induced in recipients by coinjection of p815 tumor cells (H-2d) at the time of transplantation, all surviving recipients of G-CSF–mobilized B6 donors were leukemia-free at day 70 after transplant, whereas all mice who received T-cell–depleted (TCD) splenocytes from G-CSF–mobilized B6 donors died of leukemia. When splenocytes from G-CSF–mobilized perforin-deficient (pfp−/−) mice were used for transplantation, 90% of recipients died of leukemia, demonstrating that perforin is a crucial pathway mediating GVL effects after G-CSF–mobilized PBSCT. These data illustrate that G-CSF–mobilized allogeneic PBSCT separate GVL from GVHD by preserving perforin-dependent donor CTL activity while reducing systemic inflammation.

Published
1999

141. 533 Extended treatment-free interval with excellent life more than two years after autologous dendritic cell vaccine therapy targeting HTLV-1 Tax for previously treated adult T-cell leukemia/lymphoma: The follow-up kinetics of cytotoxic T lymphocytes and HTLV-1 viral load

Author

Suehiro, Y., primary, Hasegawa, A., additional, Iino, T., additional, Fujioka, E., additional, Watanabe, N., additional, Tanosaki, R., additional, Utsunomiya, A., additional, Choi, I., additional, Matsuoka, M., additional, Shiratsuchi, M., additional, Teshima, T., additional, Akashi, K., additional, Uike, N., additional, Okamura, J., additional, and Kannagi, M., additional

Published
2015
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144. CD4/CD8 Double-negative T-cell Lymphoma: A Variant of Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma?

Author

Miyauchi, T, primary, Abe, R, additional, Morita, Y, additional, Adachi, M, additional, Shiba, K, additional, Hamade, Y, additional, Saito, N, additional, Nishimura, M, additional, Ibata, M, additional, Okada, K, additional, Shigematsu, A, additional, Endo, T, additional, Kawai, K, additional, Teshima, T, additional, and Shimizu, H, additional

Published
2015
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145. ��\to��^0����and ��\to��^0��^0��decays and Mixing Between Low and High Mass Scalar Mesons

Author

Teshima, T., Kitamura, I., and Morisita, N.

Subjects
High Energy Physics - Phenomenology (hep-ph), FOS: Physical sciences
Abstract

Radiative decays ��\to����^0��and ��\to��^0��^0��are studied assuming that these decays are caused through the intermediate a_0(980)��and f_0(980)��states, respectively. Fitting the experimental data of the ����^0 and ��^0��^0 invariant mass spectrum in the decays ��\to����^0��and ��^0��^0��, it is shown that the processes ��\to a_0��and ��\to f_0��are dominated by the K^+K^- loop interaction rather than the contact ��a_0(f_0)��one both for the non-derivative and derivative SPP coupling. The experimental data of ��[��\to f_0��]/��[��\to a_0��] predicts that g_{f_0K\bar{K}}/g_{a_0K\bar{K}} \sim 2. Considering the effects of the mixing between low mass scalar qq\bar{q}\bar{q} states and high mass scalar q\bar{q} states to these coupling constants g_{f_0K\bar{K}} and g_{a_0K\bar{K}}, one suggests that the mixing is rather large., 15 pages, 10 figures

Published
2007
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148. Excellent Quality of Lives for Previously Treated Adult T-Cell Leukemia/Lymphoma Patients After Autologous Dendritic Cell Vaccine Therapy Targeting Htlv-1 Tax Antigens

Author

Suehiro, Y., primary, Iino, T., additional, Hasegawa, A., additional, Watanabe, N., additional, Matsuoka, M., additional, Tanosaki, R., additional, Utsunomiya, A., additional, Choi, I., additional, Shiratsuchi, M., additional, Teshima, T., additional, Akashi, K.A., additional, Kannagi, M., additional, Uike, N., additional, and Okamura, J., additional

Published
2014
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