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1,763 results on '"Terashima, T"'

112. Fragile superheavy Fermi liquid in YbCo2Zn20

Author

Shimura, Y., primary, Kitazawa, T., additional, Tsuda, S., additional, Bachus, S., additional, Tokiwa, Y., additional, Gegenwart, P., additional, Yamamoto, R., additional, Yamane, Y., additional, Nishihara, I., additional, Umeo, K., additional, Onimaru, T., additional, Takabatake, T., additional, Hirose, H. T., additional, Kikugawa, N., additional, Terashima, T., additional, and Uji, S., additional

Published
2020
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115. Essential roles of G9a in cell proliferation and differentiation during tooth development

Author

Kamiunten, T., Ideno, H., Shimada, A., Arai, Y., Terashima, T., Tomooka, Y., Nakamura, Y., Nakashima, K., Kimura, Hiroshi, Shinkai, Y., Tachibana, M., and Nifuji, A.

Subjects
0301 basic medicine, endocrine system, Mesenchyme, Mice, Transgenic, SOX9, Biology, Bone morphogenetic protein, Epithelium, Mesoderm, 03 medical and health sciences, Cranial neural crest, FGF9, stomatognathic system, Tooth/*growth & development, Conditional gene knockout, medicine, Animals, Transcription Factors/metabolism, Differentiation, Cell Proliferation, Epigenetics, Odontogenesis/physiology, FGF10, Inner enamel epithelium, Bone Morphogenetic Proteins/metabolism, Gene Expression Regulation, Developmental, Cell Differentiation, Fibroblast Growth Factors/metabolism, Cell Biology, Histone-Lysine N-Methyltransferase, Cell Proliferation/*physiology, Cell biology, Fibroblast Growth Factors, Cell Differentiation/*physiology, Epithelium/metabolism, stomatognathic diseases, 030104 developmental biology, medicine.anatomical_structure, Histone-Lysine N-Methyltransferase/genetics/*metabolism, Tooth development, Mesoderm/cytology, Immunology, Bone Morphogenetic Proteins, embryonic structures, Odontogenesis, Tooth, Gene Expression Regulation, Developmental/*physiology, Transcription Factors
Abstract

Teeth develop through interactions between epithelial and mesenchymal tissues mediated by a signaling network comprised of growth factors and transcription factors. However, little is known about how epigenetic modifiers affect signaling pathways and thereby regulate tooth formation. We previously reported that the histone 3 lysine 9 (H3K9) methyltransferase (MTase) G9a is specifically enriched in the tooth mesenchyme during mouse development. In this study, we investigated the functions of G9a in tooth development using G9a conditional knockout (KO) mice. We used Sox9-Cre mice to delete G9a in the tooth mesenchyme because Sox9 is highly expressed in the mesenchyme derived from the cranial neural crest. Immunohistochemical analyses revealed that G9a expression was significantly decreased in the mesenchyme of Sox9-Cre;G9afl/fl (G9a cKO) mice compared with that in Sox9-Cre;G9a fl/+(control) mice. Protein levels of the G9a substrate H3K9me2 were also decreased in the tooth mesenchyme. G9a cKO mice showed smaller tooth germ after embryonic day (E) 16.5 and E17.5, but not at E15.5. The developing cusp tips, which were visible in control mice, were absent in G9a cKO mice at E17.5. At 3 weeks after birth, small first molars with smaller cusps and unseparated roots were formed. Organ culture of tooth germs derived from E15.5 cKO mouse embryos showed impaired tooth development, suggesting that tooth development per se is affected independently of skull development. BrdU labeling experiments revealed that the proliferation rates were decreased in the mesenchyme in G9a cKO mice at E17.5. In addition, the proliferation rates in the tooth inner enamel epithelium were also decreased. In situ hybridization revealed altered localization of genes associated with tooth development. In cKO mice, intensively localized expression of mRNAs encoding bone morphogenic protein (Bmp2 and Bmp4) was observed in the tooth mesenchyme at E17.5, similar to the expression patterns observed in control mice at E15.5. Localization of Shh and related signaling components, including Gli1, Ptch1, and Ptch2, in the tooth mesenchyme of cKO mice was generally similar to that at earlier stages in control mice. In addition, expression of Fgf3 and Fgf10 in the mesenchyme was decreased in G9a cKO mice at P0. Expression levels of Fgf9 and p21, both of which were expressed in the secondary enamel-knot, were also decreased. Thus, the expression of genes associated with tooth development was delayed in cKO mice. Our results suggest that H3K9MTase G9a regulates cell proliferation and timing of differentiation and that G9a expression in the tooth mesenchyme is required for proper tooth development.

Published
2017

126. High critical-current density in the heavily Pb-doped Bi2Sr2CaCuO(sub 8+delta) superconductor: generation of efficient pinning centers

Author

Chong, I., Hiroi, Z., Izumi, M., Shimoyama, J., Nakayama, Y., Kishio, K., Terashima, T., Bando, Y., and Takano, M.

Subjects
High temperature superconductors -- Research, Copper oxide superconductors -- Research, Science and technology, Research
Abstract

Critical-current density ([J.sub.c]) is a parameter of primary importance for potential applications of high-temperature copper oxide superconductors. It is limited principally by the breakdown of zero-resistive current due to thermally activated flux flow at high temperatures and high magnetic fields. One promising method to overcome this limitation is to introduce efficient pinning centers into crystals that can suppress the flux flow. A marked increase in [J.sub.c] was observed in [Bi.sub.2][Sr.sub.2][CaCu.sub.2][O.sub.8+Δ (Bi-2212) single crystals doped with a large amount of Pb. By electron microscopy, characteristic microstructures were revealed that probably underlie the observed enhancement in [J.sub.c]: thin (10 to 50 nanometers), platelike domains having a modulation-free structure appeared with spacings of 50 to 100 nanometers along the b axis., High-temperature copper oxide superconductors (HTSCs) exhibit an unusual magnetic field-temperature (H-T) phase diagram that differs from that of conventional superconductors (1, 2). The major reason is the strongly two-dimensional (2D) [...]

Published
1997

132. Epitaxial growth and dielectric properties of BaTiO3 films on Pt electrodes by reactive evaporation

Author

Yano, Y., Iijima, K., Daitoh, Y., Terashima, T., Bando, Y., Watanabe, Y., Kasatani, H., and Terauchi, H.

Subjects
Thin films -- Research, Epitaxy -- Analysis, Dielectric measurements -- Analysis, Physics
Abstract

Electron diffraction and transmission electron microscope analyses of BaTiO3 thin films on Pt/MgO substrates reveal the absence of other phase formations at the onset of epitaxial growth. An increase in rate of deposition converts the BaTiO3 islands on the Pt surface to a continuous layer, as revealed by atomic force microscopy. Enhancement of film thickness causes a variation in lattice parameters and dielectric properties. The thermodynamic theory accounts for the increase in dielectric constant with film thickness up to a value of 700.

Published
1994

134. Atomic layer growth of oxide thin films with perovskite-type structure by reactive evaporation

Author

Iijima, K., Terashima, T., Bando, Y., Kamigaki, K., and Terauchi, H.

Subjects
Thin films -- Research, Crystals -- Growth, Physics
Abstract

The atomic layer growth of oxide thin films with perovskite-type structure by reactive evaporation was investigated using reflection high-energy electron diffraction. The results showed that the alternate supply of Ba or Sr and Ti on the growing surface allowed atomic layer growth to be achieved. In coevaporation, epitaxial growth was characterized by a unit-cell-by-unit-cell mode, with the surface of each unit cell terminated by a TiO2 layer.

Published
1992

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