101. A Comparative Study of Point-of-Care Prothrombin Time in Cardiopulmonary Bypass Surgery
- Author
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Kenichi A. Tanaka, Toshiki Mizobe, Teiji Sawa, Takashi Nishiyama, Shihoko Okabayashi, Satoru Ogawa, Yoshinobu Nakayama, Yasufumi Nakajima, and Shusuke Takeshita
- Subjects
Adult ,Male ,Point-of-care testing ,Point-of-Care Systems ,030204 cardiovascular system & hematology ,law.invention ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,030202 anesthesiology ,law ,Monitoring, Intraoperative ,Cardiopulmonary bypass ,Medicine ,Humans ,International Normalized Ratio ,Prospective Studies ,Point of care ,Prothrombin time ,Cardiopulmonary Bypass ,medicine.diagnostic_test ,business.industry ,Warfarin ,Anticoagulants ,Heparin ,Middle Aged ,Prothrombin complex concentrate ,Anesthesiology and Pain Medicine ,Coagulation ,Anesthesia ,Prothrombin Time ,Female ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Point-of-care (POC) devices allow for prothrombin time/international normalized ratio (PT/INR) testing in whole blood (WB) and timely administration of plasma or prothrombin complex concentrate during cardiopulmonary bypass surgery. This study evaluated the sensitivities of a new POC PT test, a dry-hematology method with heparin neutralization technology (DRIHEMATO PT-S [DRI PT-S]; AT Corporation, Kanagawa, Japan), and compared it with other POC tests currently available.Prospective, observational study.University hospital, single center.Healthy volunteers and warfarin-treated and cardiac surgical patients.In WB samples obtained from 6 healthy volunteers, PT-INR results of DRI PT-S were not affected by an in vitro addition of heparin6.0 U/mL. In warfarin-treated samples (n = 88, PT/INR 0.98-3.87), PT-INR with DRI PT-S showed acceptable correlation with the laboratory method (rThis study demonstrated that PT/INR can be accurately assessed using the dry-hematology method in WB under therapeutic heparin levels. Currently available other POC PT/INR tests are affected by heparin, and thus they are not recommended for coagulation monitoring during cardiopulmonary bypass.
- Published
- 2017