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593 results on '"Tang, Jinhai"'

104. Effect of an Artificial Intelligence Clinical Decision Support System on Treatment Decisions for Complex Breast Cancer

Author

Xu, Fengrui, primary, Sepúlveda, Martín-J., additional, Jiang, Zefei, additional, Wang, Haibo, additional, Li, Jianbin, additional, Liu, Zhenzhen, additional, Yin, Yongmei, additional, Roebuck, M. Christopher, additional, Shortliffe, Edward H., additional, Yan, Min, additional, Song, Yuhua, additional, Geng, Cuizhi, additional, Tang, Jinhai, additional, Purcell Jackson, Gretchen, additional, Preininger, Anita M., additional, and Rhee, Kyu, additional

Published
2020
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114. Addendum: Metabolic Syndrome, and Particularly the Hypertriglyceridemic-Waist Phenotype, Increases Breast Cancer Risk, and Adiponectin Is a Potential Mechanism: A Case–Control Study in Chinese Women

Author

Xiang, Yujuan, primary, Zhou, Wenzhong, additional, Duan, Xuening, additional, Fan, Zhimin, additional, Wang, Shu, additional, Liu, Shuchen, additional, Liu, Liyuan, additional, Wang, Fei, additional, Yu, Lixiang, additional, Zhou, Fei, additional, Huang, Shuya, additional, Li, Liang, additional, Zhang, Qiang, additional, Fu, Qinye, additional, Ma, Zhongbing, additional, Gao, Dezong, additional, Cui, Shude, additional, Geng, Cuizhi, additional, Cao, Xuchen, additional, Yang, Zhenlin, additional, Wang, Xiang, additional, Liang, Hong, additional, Jiang, Hongchuan, additional, Wang, Haibo, additional, Li, Guolou, additional, Wang, Qitang, additional, Zhang, Jianguo, additional, Jin, Feng, additional, Tang, Jinhai, additional, Tian, Fuguo, additional, Ye, Chunmiao, additional, and Yu, Zhigang, additional

Published
2020
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121. Current Status and Factors Influencing Surgical Options for Breast Cancer in China: A Nationwide Cross-Sectional Survey of 110 Hospitals

Author

Yang, Benlong, primary, Ren, Guosheng, additional, Song, Erwei, additional, Pan, Da, additional, Zhang, Jing, additional, Wang, Yongsheng, additional, Liao, Ning, additional, Tang, Jinhai, additional, Wang, Xiang, additional, Cui, Shude, additional, Jin, Feng, additional, Geng, Cuizhi, additional, Sun, Qiang, additional, Li, Hongyuan, additional, Fan, Zhimin, additional, Cao, Xuchen, additional, Wang, Haibo, additional, Wang, Shu, additional, Shao, Zhimin, additional, and Wu, Jiong, additional

Published
2020
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123. Abstract P1-17-02: Relationship of lifestyle habits to quality of life of recently diagnosed breast cancer between younger and older women in China

Author

Zheng, Chao, primary, Liu, Liyuan, additional, Cui, Shude, additional, Tian, Fuguo, additional, Fan, Zhimin, additional, Geng, Cuizhi, additional, Cao, Xuchen, additional, Yang, Zhenlin, additional, Wang, Xiang, additional, Liang, Hong, additional, Wang, Shu, additional, Jiang, Hongchuan, additional, Duan, Xuening, additional, Wang, Haibo, additional, Li, Guolou, additional, Wang, Qitang, additional, Zhang, Jianguo, additional, Jin, Feng, additional, Tang, Jinhai, additional, Li, Liang, additional, Zhu, Shiguang, additional, Zuo, Wenshu, additional, Wang, Fei, additional, Yu, Lixiang, additional, Zhou, Fei, additional, Xiang, Yujuan, additional, Guo, Mingming, additional, Wang, Yongjiu, additional, Huang, Shuya, additional, Ma, Zhongbing, additional, Gao, Dezong, additional, Zhang, Qiang, additional, Fu, Qinye, additional, and Yu, Zhigang, additional

Published
2020
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124. Metabolic Syndrome, and Particularly the Hypertriglyceridemic-Waist Phenotype, Increases Breast Cancer Risk, and Adiponectin Is a Potential Mechanism: A Case–Control Study in Chinese Women

Author

Xiang, Yujuan, primary, Zhou, Wenzhong, additional, Duan, Xuening, additional, Fan, Zhimin, additional, Wang, Shu, additional, Liu, Shuchen, additional, Liu, Liyuan, additional, Wang, Fei, additional, Yu, Lixiang, additional, Zhou, Fei, additional, Huang, Shuya, additional, Li, Liang, additional, Zhang, Qiang, additional, Fu, Qinye, additional, Ma, Zhongbing, additional, Gao, Dezong, additional, Cui, Shude, additional, Geng, Cuizhi, additional, Cao, Xuchen, additional, Yang, Zhenlin, additional, Wang, Xiang, additional, Liang, Hong, additional, Jiang, Hongchuan, additional, Wang, Haibo, additional, Li, Guolou, additional, Wang, Qitang, additional, Zhang, Jianguo, additional, Jin, Feng, additional, Tang, Jinhai, additional, Tian, Fuguo, additional, Ye, Chunmiao, additional, and Yu, Zhigang, additional

Published
2020
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125. Clinical and transcriptional signatures of human CD204 reveal an applicable marker for the protumor phenotype of tumor-associated macrophages in breast cancer

Author

He, Yunjie, primary, Zhou, Siying, additional, Deng, Fei, additional, Zhao, Shujie, additional, Chen, Wenquan, additional, Wang, Dandan, additional, Chen, Xiu, additional, Hou, Juncheng, additional, Zhang, Jian, additional, Zhang, Wei, additional, Ding, Li, additional, Tang, Jinhai, additional, and Zhou, Zuomin, additional

Published
2019
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126. Artificial Intelligence Treatment Decision Support For Complex Breast Cancer Among Oncologists With Varying Expertise

Author

Xu, Fengrui, primary, Sepúlveda, Martín-José, additional, Jiang, Zefei, additional, Wang, Haibo, additional, Li, Jianbin, additional, Yin, Yongmei, additional, Liu, Zhenzhen, additional, Roebuck, M. Christopher, additional, Shortliffe, Edward H., additional, Yan, Min, additional, Song, Yuhua, additional, Geng, Cuizhi, additional, Tang, Jinhai, additional, and Rhee, Kyu, additional

Published
2019
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129. Functional miRNAs in breast cancer drug resistance

Author

Hu,Weizi, Tan,Chunli, He,Yunjie, Zhang,Guangqin, Xu,Yong, and Tang,Jinhai

Subjects
OncoTargets and Therapy
Abstract

Weizi Hu,1–3,* Chunli Tan,1–3,* Yunjie He,4 Guangqin Zhang,2 Yong Xu,3,5 Jinhai Tang1 1Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, 2School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 3Nanjing Medical University Affiliated Cancer Hospital, 4The First Clinical School of Nanjing Medical University, 5Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Nanjing Medical University, Nanjing, People’s Republic of China *These authors contributed equally tothiswork Abstract: Owing to improved early surveillance and advanced therapy strategies, the current death rate due to breast cancer has decreased; nevertheless, drug resistance and relapse remain obstacles on the path to successful systematic treatment. Multiple mechanisms responsible for drug resistance have been elucidated, and miRNAs seem to play a major part in almost every aspect of cancer progression, including tumorigenesis, metastasis, and drug resistance. In recent years, exosomes have emerged as novel modes of intercellular signaling vehicles, initiating cell–cell communication through their fusion with target cell membranes, delivering functional molecules including miRNAs and proteins. This review particularly focuses on enumerating functional miRNAs involved in breast cancer drug resistance as well as their targets and related mechanisms. Subsequently, we discuss the prospects and challenges of miRNA function in drug resistance and highlight valuable approaches for the investigation of the role of exosomal miRNAs in breast cancer progression and drug resistance. Keywords: microRNA, exosome, breast cancer, drug resistance

Published
2018

136. Association of PTPN1 polymorphisms with breast cancer risk: A case‐control study in Chinese females

Author

Huang, Shuya, primary, Liu, Liyuan, additional, Xiang, Yujuan, additional, Wang, Fei, additional, Yu, Lixiang, additional, Zhou, Fei, additional, Cui, Shude, additional, Tian, Fuguo, additional, Fan, Zhimin, additional, Geng, Cuizhi, additional, Cao, Xuchen, additional, Yang, Zhenlin, additional, Wang, Xiang, additional, Liang, Hong, additional, Wang, Shu, additional, Jiang, Hongchuan, additional, Duan, Xuening, additional, Wang, Haibo, additional, Li, Guolou, additional, Wang, Qitang, additional, Zhang, Jianguo, additional, Jin, Feng, additional, Tang, Jinhai, additional, Li, Liang, additional, Zhu, Shiguang, additional, Zuo, Wenshu, additional, Ye, Chunmiao, additional, Zhou, Wenzhong, additional, Yin, Gengshen, additional, Ma, Zhongbing, additional, and Yu, Zhigang, additional

Published
2019
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143. The long non‐coding RNA landscape in triple‐negative breast cancer.

Author

Zhang, Wenwen, Guan, Xiaoxiang, and Tang, Jinhai

Subjects
LINCRNA, TRIPLE-negative breast cancer, OLIGONUCLEOTIDES, BREAST cancer, GENETIC techniques, NUCLEIC acids
Abstract

Triple‐negative breast cancer (TNBC) is a type of breast cancer that has a higher risk of distant recurrence and metastasis, leading to a relatively aggressive biological behaviour and poor outcome. So far, the clinical management of TNBC is challenging because of its heterogeneity and paucity of specific targeted therapy. Recently, various studies have identified a lot of differently expressed long non‐coding RNAs (lncRNAs) in TNBC. Those lncRNAs have been reported to play important roles in the multistep process of TNBC tumorigenesis. Here, we review the biological characteristics of lncRNAs, and present the current state of knowledge concerning the expression, function and regulation of lncRNAs in TNBC. Accumulating studies explored the potential lncRNAs‐based therapeutics in TNBC, including the techniques of genetic modification using antisense oligonucleotides, locked nucleic acid and RNA nanotechnology. In current review, we also discuss the future prospects of studies about lncRNAs in TNBC and development of lncRNA‐based strategies for clinical TNBC patients. [ABSTRACT FROM AUTHOR]

Published
2021
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144. Hsa_circ_0000515 is a novel circular RNA implicated in the development of breast cancer through its regulation of the microRNA‐296‐5p/CXCL10 axis.

Author

Cai, Fenglin, Fu, Wenjie, Tang, Lei, Tang, Jinhai, Sun, Jinming, Fu, Guangshun, and Ye, Gang

Subjects
CIRCULAR RNA, BREAST cancer, METASTASIS, CELL cycle, REPORTER genes, CELL proliferation
Abstract

Cancer metastasis is a major cause of death among women afflicted with breast cancer (BC) and understanding the molecular processes involved is a major focus in BC research. Circular RNAs (circRNAs) have emerged as genomic regulatory molecules in carcinogenesis and metastasis; however, their role in BC is unclear. We characterized a novel circRNA, hsa_circ_0000515, in context of BC. We collected 340 cancerous tissues surgically resected from BC patients and found hsa_circ_0000515 was upregulated in BC tissues and associated with poor prognosis of BC. Silencing of hsa_circ_0000515 impaired cell cycle progression, cell proliferation, and invasion, attenuated inflammatory response, and reduced the proangiogenetic potential of BC cells. RNA pull‐down and dual‐luciferase reporter gene assays showed that hsa_circ_0000515 binds miR‐296‐5p, preventing it from repressing CXCL10 expression. We also observed that miR‐296‐5p inhibition or CXCL10 overexpression promoted cell cycle progression, restored proliferative, invasive and proangiogenetic abilities, and increased inflammatory response in MCF‐7 cells in the absence of hsa_circ_0000515. In vivo analyses showed that partial loss of hsa_circ_0000515 reduced the tumor growth of MCF‐7 cells in nude mice. The key findings from this study revealed that targeting hsa_circ_0000515 might be an effective strategy to combat BC. [ABSTRACT FROM AUTHOR]

Published
2021
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145. Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis

Author

Liu Jiyong, Jin Guangfu, Wang Xuechen, Wang Shui, Qin Jianwei, Tang Jinhai, Hu Zhibin, Gao Jun, Zhai Xiangjun, Chen Wenshen, Chen Feng, Wang Xinru, Wei Qingyi, and Shen Hongbing

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Accumulative evidence suggests that low folate intake is associated with increased risk of breast cancer. Polymorphisms in genes involved in folate metabolism may influence DNA methylation, nucleotide synthesis, and thus individual susceptibility to cancer. Thymidylate synthase (TYMS) is a key enzyme that participates in folate metabolism and catalyzes the conversion of dUMP to dTMP in the process of DNA synthesis. Two potentially functional polymorphisms [a 28-bp tandem repeat in the TYMS 5'-untranslated enhanced region (TSER) and a 6-bp deletion/insertion in the TYMS 3'-untranslated region (TS 3'-UTR)] were suggested to be correlated with alteration of thymidylate synthase expression and associated with cancer risk. Methods To test the hypothesis that polymorphisms of the TYMS gene are associated with risk of breast cancer, we genotyped these two polymorphisms in a case-control study of 432 incident cases with invasive breast cancer and 473 cancer-free controls in a Chinese population. Results We found that the distribution of TS3'-UTR (1494del6) genotype frequencies were significantly different between the cases and controls (P = 0.026). Compared with the TS3'-UTR del6/del6 wild-type genotype, a significantly reduced risk was associated with the ins6/ins6 homozygous variant genotype (adjusted OR = 0.58, 95% CI = 0.35–0.97) but not the del6/ins6 genotype (OR = 1.09, 95% CI = 0.82–1.46). Furthermore, breast cancer risks associated with the TS3'-UTR del6/del6 genotype were more evident in older women, postmenopausal subjects, individuals with a younger age at first-live birth and individuals with an older age at menarche. However, there was no evidence for an association between the TSER polymorphism and breast cancer risks. Conclusion These findings suggest that the TS3'-UTR del6 polymorphism may play a role in the etiology of breast cancer. Further larger population-based studies as well as functional evaluation of the variants are warranted to confirm our findings.

Published
2006
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