Search

Your search keyword '"Takehana, K."' showing total 497 results
Start Over Author "Takehana, K."
497 results on '"Takehana, K."'

102. Clinical significance of ischemic electrocardiographic changes during stress myocardial perfusion imaging: sub-analysis of the J-ACCESS study.

Author

Takehana K, Nishimura S, Maeba H, Ueyama T, Iwasaka T, Nishimura T, Takehana, Kazuya, Nishimura, Shigeyuki, Maeba, Hirofumi, Ueyama, Takanao, Iwasaka, Toshiji, and Nishimura, Tsunehiko

Abstract

Objectives: The cardiac event rate among the countries varies according to ethnicity. Some reports have identified that ischemic heart disease often occurs at a low incidence and is often milder in Japan compared to other countries. Therefore, the present study was designed to determine the clinical significance and prediction for cardiac events in patients who showed ischemic ECG changes during stress myocardial perfusion SPECT. Methods: Among 4,670 registered patients for Japanese-assessment of cardiac event and survival (J-ACCESS) study, patients with conduction abnormality on baseline were excluded and revascularization within 60 days of SPECT study were censored from the prognostic portion of analysis. Stress and rest myocardial perfusion SPECT imaging with (99m)Tc-tetrofosmin were performed and occurrence and nature of cardiac events were investigated at 1, 2 and 3 years after registration. Both PCI and CABG, as well as recurrent angina and non-severe heart failure were classified as soft events. Cardiac death, non-fatal MI and heart failure requiring hospitalization were classified as major cardiac events, and hard events comprised cardiac death and non-fatal MI. Results: A total of 3,125 patients performed exercise (n = 2,383) or vasodilator (n = 742) stress MPI and significant ischemic ECG changes were obtained in 538 during exercise and 35 during vasodilator stress. Kaplan-Meier analysis revealed that the patients with both ischemic ECG changes and reversible perfusion defect on MPI had significantly higher incidence for major cardiac events, such as cardiac death, non-fatal MI and severe heart failure (P = 0.0038), and for cardiac hard events, such as cardiac death and non-fatal MI (P = 0.0028), in exercise stress. Interestingly, patients without reversible perfusion defect showed significantly fewer events despite presence of ischemic ECG changes. Conclusions: Ischemic ECG changes during exercise stress are well associated with higher incidence of cardiac events in patients demonstrated reversible perfusion defect on MPI. [ABSTRACT FROM AUTHOR]

Published
2010
Full Text
View/download PDF

105. Immunohistochemical Study of the Distribution of Endocrine Cells in theGastrointestinal Tract of the Camel ( Camelus bactrianus ).

Author

Eerdunchaolu, D.V.M., Takehana, K., Kobayashi, A., Yamada, J., Ueda, H., Baiyin, Cao, G.F., and Abe, M.

Subjects
*ENDOCRINE glands, *GASTROINTESTINAL system, *CAMELS, *IMMUNOHISTOCHEMISTRY, *CYTOCHEMISTRY
Abstract

The regional distribution and relative frequency of endocrine cells in the gastrointestinal tract of the camel, Camelus bactrianus, were investigated using immunohistochemical methods. Ten types of immunoreactive (IR) endocrine cells were identified in this study. Among these cell types, only serotonin- and somatostatin-IR cells were detected in almost all regions of the gastrointestinal tract. Most of the cell types showed peak density in the pyloric gland region. The others showed restricted distribution: gastrin, cholecystokinin (CCK), motilin, bovine pancreatic polypeptide (BPP), and (gastric) substance P in the stomach; gastrin, CCK, BPP, gastric inhibitory polypeptide (GIP), glucagon, peptide tyrosine tyrosine (PYY) and substance P in the small intestine; and CCK, motilin, BPP, and PYY in the large intestine. Fundamentally the distribution pattern of endocrine cells in the gastrointestinal tract of the camel is similar to that of cattle. The distribution and frequency of endocrine cells in the glandular sac region are the same as those of the cardiac gland. [ABSTRACT FROM AUTHOR]

Published
2001
Full Text
View/download PDF

106. The role of infarction-associated pericarditis on the occurrence of atrial fibrillation.

Author

Nagahama, Y., Sugiura, T., Takehana, K., Hatada, K., Inada, M., and Iwasaka, T.

Abstract

AimsTransient atrial fibrillation is a relatively common arrhythmia in the early phase of acute Q-wave myocardial infarction. However, the role of infarction-associated pericarditis on the genesis of atrial fibrillation is controversial. This study was designed to examine the relative importance of infarction-associated pericarditis among other clinical variables on the genesis of transient atrial fibrillation in patients with acute myocardial infarction.Methods and resultsThree hundred and ninety-eight patients with acute Q-wave myocardial infarction were examined carefully by means of auscultation, ECG, two-dimensional echocardiography and haemodynamic measurements. The diagnosis of pericarditis was made on the basis of pericardial rub detected during the first 3 days after admission. At least 0·5mm of PQ-segment depression from a TP segment lasting more than 24h in both limb and precordial leads was considered diagnostic of PQ-segment depression. Atrial fibrillation was present in 76 patients (19%). Sixteen (42%) of 38 patients with PQ-segment depression had atrial fibrillation, whereas 23 (30%) of 77 patients with pericardial rub had atrial fibrillation. Based on ten clinical variables, multivariate analysis was performed to determine the important variables related to the occurrence of atrial fibrillation. PQ-segment depression (chi-square=4·10, P<0·05) was selected with age (chi-square=10·52, P<0·005), the number of left ventricular segments with advanced asynergy (chi-square=7·73, P<0·01) and pericardial effusion (chi-square=7·95, P<0·005) as important factors related to atrial fibrillation. Patients with PQ-segment depression had a significantly higher pulmonary capillary wedge pressure than those without it.ConclusionAmong patients with infarction-associated pericarditis, those with PQ-segment depression represent atrial involvement associated with extensive myocardial damage and hence, PQ-segment depression is one of the clinical signs related to the occurrence of atrial fibrillation in acute Q-wave myocardial infarction. [ABSTRACT FROM PUBLISHER]

Published
1998
Full Text
View/download PDF

115. Importance of left ventricular diastolic function on maintenance of exercise capacity in patients with systolic dysfunction after anterior myocardial infarction

Author

Sumimoto, T., Jikuhara, T., Hattori, T., Yuasa, F., Kaida, M., Hikosaka, M., Takehana, K., Tamura, T., Sugiura, T., and Iwasaka, T.

Abstract

To investigate the role of left ventricular (LV) diastolic function in the maintenance of exercise capacity in patients with systolic dysfunction, symptom-limited cardiopulmonary exercise testing combined with radionuclide ventriculography was performed in 24 patients with an LV ejection fraction <35% after anterior myocardial infarction. The ratio of pulmonary artery wedge pressure (PAWP) to LV end-diastolic volume (EDV), an index of global diastolic function, correlated significantly with peak oxygen consumption at peak exercise (r = -0.55; p = 0.006), whereas ejection fraction at peak exercise did not. The change in PAWP/EDV ratio from rest to peak exercise was related to the increases in stroke volume (r = -0.54; p = 0.006) and cardiac output (r = -0.51; p = 0.01) during exercise, but the change in ejection fraction was not. Resting hemodynamics did not differ between patients with preserved exercise capacity (group 1,n = 8) and those with exercise impairment (group 2,n = 16). At peak exercise, stroke volume, cardiac output, and EDV were significantly higher, and PAWP and PAWP/EDV ratio were significantly lower in group 1 than in group 2, but ejection fraction and end-systolic volume were similar in both groups. Although the incidences of hypertension, LV hypertrophy, and infarct-related coronary artery lesions did not differ between the two groups, group 2 had a significantly higher incidence of non-infarct-related coronary artery lesions than group 1 (p < 0.05). Thus in patients with LV systolic dysfunction after anterior myocardial infarction, the major cause of exercise impairment and failure to increase LV performance during exercise was diastolic dysfunction associated with the presence of non-infarct-related coronary artery lesions with the potential for exercise-induced ischemia of the noninfarcted areas. (Am Heart J 1997;133:87-93.)

Published
1997
Full Text
View/download PDF

116. Josephson plasma observed in underdoped (110) YBa[sub 2]Cu[sub 3]O[sub 7-δ] films.

Author

Qiu, X. G., Koinuma, H., Iwasaki, M., Itoh, T., Sarin Kumar, A. K., Kawasaki, M., Saitoh, E., Tokura, Y., Takehana, K., Kido, G., and Segawa, Y.

Subjects
THIN films, EPITAXY, PULSED laser deposition, JOSEPHSON effect
Abstract

(110) oriented YBa[sub 2]Cu[sub 3]O[sub 7-δ] thin films have been epitaxially grown on vicinal (110)SrTiO[sub 3] substrates by pulsed-laser deposition. Films with different oxygen deficiencies were obtained by annealing under various oxygen ambient. These films have very smooth surface and with their c axis aligned in one direction in the substrate plane. Electronic transport and polarized far-infrared reflectivity measurements reveal the unique features of the c-axis charge dynamics. A c-axis far-infrared reflectivity edge associated with the Josephson plasma in the superconducting state is observed. Our results demonstrate the potential usage of (110) thin films for the investigation of intrinsic interlayer charge dynamics as well as device application of high T[sub c] superconductors. [ABSTRACT FROM AUTHOR]

Published
2001
Full Text
View/download PDF

130. Electrical-field-induced insulator-to-metal transition in samarium monosulfides.

Author

Kishida, K., Shibutani, J., Hatano, T., Yokoyama, Y., Katayama, N., Okamoto, Y., Nakamura, Y., Kishida, H., Suzuki, H. S., Takehana, K., Imanaka, Y., and Takenaka, K.

Subjects
*SAMARIUM, *VALENCE fluctuations, *ELECTRIC fields, *VISIBLE spectra
Abstract

Electrical-field-induced insulator-to-metal (I-to-M) transition of samarium monosulfides was investigated systematically. Experiment results demonstrate that Sm0.9Ca0.1S undergoes the I-to-M transition when in a small electric field of 250 V/cm at liquid-nitrogen temperatures. However, simultaneous measurement of I–V characteristics and strain did not detect the electrical-field-induced strain expected from the large volume contraction originating from the valence transition of Sm. Mid-infrared to visible region reflectivity spectroscopy in the field-induced transition revealed no spectral change other than the temperature change attributable to Joule heat. This lack of change contrasts to the large-scale spectrum changes, such as a sharp rise in reflectivity, which appear in the metallic phase induced by pressure or element substitution. The detailed analysis of the field-induced strain suggests that filamentary metallic paths are formed during the breakdown process, just as they are for strongly correlated insulators. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

134. Worldwide Disparities in Recovery of Cardiac Testing 1 Year Into COVID-19

Author

Andrew J. Einstein, Cole Hirschfeld, Michelle C. Williams, Joao V. Vitola, Nathan Better, Todd C. Villines, Rodrigo Cerci, Leslee J. Shaw, Andrew D. Choi, Sharmila Dorbala, Ganesan Karthikeyan, Bin Lu, Valentin Sinitsyn, Alexey A. Ansheles, Takashi Kudo, Chiara Bucciarelli-Ducci, Bjarne Linde Nørgaard, Pál Maurovich-Horvat, Roxana Campisi, Elisa Milan, Lizette Louw, Adel H. Allam, Mona Bhatia, Lorenzo Sewanan, Eli Malkovskiy, Yosef Cohen, Michael Randazzo, Jagat Narula, Olga Morozova, Thomas N.B. Pascual, Yaroslav Pynda, Maurizio Dondi, Diana Paez, Gerd Hinterleitner, Yao Lu, Zhuoran Xu, Cole B. Hirschfeld, Ikenna Erinne, Mrinali Shetty, Andrew Choi, Juan Lopez-Mattei, Purvi Parwani, Artan Goda, Ervina Shirka, Salah Bouyoucef, Lydia Chelghoum, Farouk Mansouri, Abdelkader Medjahedi, Qais Naili, Mokhtar Ridouh, Diego Alasia, Lucia Alberghina, Natalia Aramayo, Diego Buchara, Franco Gabriel Busso, Jose Javier Bustos Rivadero, Jorge Camilletti, Hugo Campanelli, Ricardo Belisario Castro, Mariana Daicz, Horacio del Riego, Laura Dragonetti, Diego Echazarreta, Juan Erriest, Fernando Faccio, Adolfo Facello, Hugo Gallegos, Ricardo Geronazzo, Horacio Glait, Victor Hasbani, Victor Jäger, Julio Manuel Lewkowicz, Jose Lotti, Neiva Maciel, Osvaldo Masoli, Edgardo Mastrovito, Maria Medus, Maria Fernanda Merani, Susana Molteni, Marcos Montecinos, Gustavo Parisi, Claudio Pereyra Sueldo, Diego Perez de Arenaza, Luis Quintana, Alejandro Radzinschi, Marcela Redruello, Marina Rodríguez, Horacio Rojas, Arturo Romero Acuña, Daniel Schere, Sonia Traverso, Gustavo Vazquez, Susana Zeffiro, Mari Sakanyan, Scott Beuzeville, Raef Boktor, Michael Crowley, D'Arne Downie, Girish Dwivedi, Barry Elison, Omar Farouque, Kim Jasper, Subodh Joshi, Joseph Lee, Kenneth Lee, Elaine Lui, Peter Mcconachie, Joanne Meaker, Dee Nandurkar, Johanne Neill, Edward O'Rourke, Patricia O'Sullivan, George Pandos, Manuja Premaratne, David Prior, Natalie Rutherford, Connor Saunders, Kim Taubman, Andrew Tauro, Andrew Taylor, James Theuerle, Paul Thomas, Jonathan Tow, Anthony Upton, Shankar Vamadevan, Victor Wayne, Eva Alina Wegner, David Wong, John Younger, Dietrich Beitzke, Gudrun Feuchtner, Oliver Sommer, Konrad Weiss, Natallia Maroz-Vadalazhskaya, Uladzimir Tserakhau, Filip Homans, Caroline M. Van De Heyning, Raúl Araujo, Valentina Soldat-Stankovic, Sinisa Stankovic, Augusto Almeida, Carlos Anselmi, Guilherme S.A. Azevedo, Marcio Sommer Bittencourt, Diego Bromfman Pianta, Estevan Cabeda, Lara Carreira, Igor Coelho, Fernando de Amorim Fernandes, Andrea de Lorenzo, Roberta Delgado, Fernanda Erthal, Fabio Fernandes, Juliano Fernandes, Thiago Ferreira de Souza, Murilo Foppa, Wilson Furlan Matos Alves, Cibele Gontijo, Ilan Gottlieb, Gabriel Grossman, Maria Helena Albernaz Siqueira, Cesar Higa Nomura, Katia Hiromoto Koga, Ronaldo Lima, Rafael Lopes, Hugo Humberto Marçal Filho, Paulo Masiero, Luiz Mastrocola, Maria Eduarda Menezes de Siqueira, Claudio Mesquita, Danilo Naves, Filipe Penna, Ibraim Pinto, Thércio Rocha, Juliana Leal Rocha, Alfredo Rodrigues, Leila Salioni, Adelina Sanches, Marcelo Santos, Leonardo Sara Da Silva, Paulo Schvartzman, Cristina Sebastião Matushita, Tiago Senra, Marcelo Silva, Carlos Eduardo Soares, Bernardo Spiro, Carlos Eduardo Suaide Silva, Rafael Torres, Guilherme Urpia Monte, Andrea Vilela, Alexandre Volney Villa, Joao Vitola, Themissa Voss, Roberto Waltrick, Marcello Zapparoli, Hamid Naseer, Marina Garcheva-Tsacheva, Tiémégna Florence Ouattara, Sarameth Thou, Soley Varoeun, Gad Abikhzer, Rob Beanlands, Michael Chetrit, Dominique Dabreo, Carole Dennie, Matthias Friedrich, Mohmmed Nassoh Hafez, Kate Hanneman, Robert Miller, Anastasia Oikonomou, Idan Roifman, Gary Small, Vikas Tandon, Adwait Trivedi, James White, Katherine Zukotynski, Rita Alay, Carmen Concha, Teresa Massardo, Pedro Abad, Kelly Anzola, Harold Arturo, Luis Benitez, Alberto Cadena, Carlos Caicedo Zamudio, Antonio Calderón, Claudia T. Gutierrez Villamil, Claudia Jaimes, Juan L. Londono, Nelson Lopez, Sonia Merlano-Gaitan, Ramon Murgieitio-Cabrera, Manuel Valencia, Damiana Vergel, Alejandro Zuluaga Santamaria, Felix Solis, Tonci Batinic, Maja Franceschi, Maja Hrabak Paar, Marina Prpic, Cuba: Juan Felipe Batista, Lazaro Omar Cabrera, Amalia Peix, Yamilé Peña, Luis Manuel Rochela Vázquez, Ioannis Ntalas, Milan Kaminek, Vladimir Kincl, Otto Lang, Jawdat Abdulla, Morten Bøttcher, Martin Busk, Uka Geisler, Lars C. Gormsen, Nicolaj Hansson, Søren Hess, Jens Hove, Lars Thorbjoern Jensen, Magnus T. Jensen, Kristian Hay Kragholm, Bjarne L. Nørgaard, Kristian Øvrehus, Jan Rasmussen, Niels Peter Rønnow Sand, Hanne Sondergaard, Tomas Zaremba, Herwin Speckter, Nelson Amores, Mayra Sanchez Velez, Taghreed Abd Alrahman, Sherif Abd Elsamad, Alia Abdelfattah, Adel Allam, Sameh Elkaffas, Mona Hassan, Elshaymaa Hussein, Ahmed Ibrahim, Ahmed Kandeel, Mohamed Mandour Ali, Mahmoud Shaaban, Camila Flores, Verónica Vanesa Gómez Leiva, Anita Liiver, Martti Larikka, Valtteri Uusitalo, Denis Agostini, Clothilde Berger, Matthieu Dietz, Fabien Hyafil, Mickaël Ohana, Kevin Prigent, Hamza Regaieg, Laure Sarda-Mantel, Darach O. H-Ici, Harold Ayetey, George Angelidis, Christina Fragkaki, Chrysoula Fragkiadaki, Panagiotis Georgoulias, Maria Koutelou, Elena Kyrozi, Niki Lama, Vassilis Prassopoulos, Michael Spartalis, Theodora Zaglavara, Carla Gonzalez, Goleat Gutierrez, Alejandro Maldonado, Yassine Martinez, Attila Kovács, Bálint Szilveszter, Nilesh Banthia, Vivek Bhat, Partha Choudhury, Vijay Sai Chowdekar, Johann Christopher, Tushar Garg, Naresh Kumar Goyal, Ripen Kumar Gupta, Abhishek Gupta, Julie Hephzibah, Shashank Jain, Jesu Krupa, Parveen Kumar, Sukriti Kumar, Arati Lalchandani, Animesh Mishra, Vivaswan Dutt Mishra, Parul Mohan, Ahmad Ozair, Shivani Pandey, Ramanathapuram Parameswaran, Chetan Patel, Tapan Patel, Shivani Patel, Leena Robinson Vimala, Dr Pradosh Kumar Sarangi, Shantanu Sengupta, Arvind Sethi, Amit Sharma, Awadhesh Kumar Sharma, Punit Sharma, Apurva Shrigiriwar, Santosh Singh, Harpreet Singh, Ashwani Sood, Atul Verma, Ajay Vyas, Erwin Affandi Soeriadi, Edison Bun, Febby Hutomo, Hilman Syawaluddin, Ryan Yudistiro, Amjed Albadr, Majid Assadi, Farshad Emami, Alireza Emami-Ardekani, Saeed Farzanehfar, Ramezan Jafari, Reyhaneh Manafi-Farid, Maryam Tajik, Yoav Arnson, Shmuel Fuchs, Ronen Goldkorn, John Kennedy, Marina Leitman, Aryeh Shalev, Wanda Acampa, Domenico Albano, Pierpaolo Alongi, Gaspare Arnone, Roberta Assante, Anna Baritussio, Matteo Bauckneht, Francesco Bianco, Rachele Bonfiglioli, Francesco Bovenzi, Isabella Bruno, Andrea Bruno, Elena Busnardo, Elena Califaretti, Roberta Casoni, Vittorio Censullo, Franca Chierichetti, Marcello Chiocchi, Corrado Cittanti, Alberto Clemente, Alberto Cuocolo, Maria Luisa De Rimini, Giuseppe De Vincentis, Veronica Della Tommasina, Santo Dellegrottaglie, Paola Anna Erba, Laura Evangelista, Lara Faggi, Evelina Faragasso, Luigia Florimonte, Viviana Frantellizzi, Marco Gatti, Angela Gaudiano, Fabrizia Gelardi, Alberto Gerali, Alessia Gimelli, Marco Guglielmo, Lucia Leccisotti, Riccardo Liga, Carlo Liguori, Giampiero Longo, Margherita Maffione, Claudio Marcassa, Giovanni Matassa, Donato Mele, Luca Mircoli, Andrea Paccagnella, Sara Pacella, Federica Padovano, Dario Pellegrini, Valeria Pergola, Luca Pugliese, Natale Quartuccio, Lucia Rampin, Fabrizio Ricci, Giuseppe Rubini, Vincenzo Russo, Gianmario Sambuceti, Alessandra Scatteia, Roberto Sciagrà, Gianluca Spidalieri, Antonella Stefanelli, Carlo Tedeschi, Guido Ventroni, Dainia Baugh, Ernest Madu, Tadao Aikawa, Hiroshi Asano, Shinichiro Fujimoto, Koichiro Fujise, Yoshimitsu Fukushima, Kae Fukuyama, Yasutaka Ichikawa, Reiko Ideguchi, Nobuo Iguchi, Masamichi Imai, Hayato Ishimura, Satoshi Isobe, Kimiteru Ito, Yu Izawa, Toshiaki Kadokami, Tokuo Kasai, Takao Kato, Takashi Kawamoto, Shigeru Kiryu, Shinichiro Kumita, Osamu Manabe, Hirotaka Maruno, Naoya Matsumoto, Masao Miyagawa, Masao Moroi, Shigeki Nagamachi, Kenichi Nakajima, Ryo Nakazato, Mamoru Nanasato, Masanao Naya, Takashi Norikane, Yasutoshi Ohta, Yoichi Otomi, Hideki Otsuka, Noriko Oyama-Manabe, Masaki Saito, Masayoshi Sarai, Junichi Sato, Daisuke Sato, Shinya Shiraishi, Kentaro Takanami, Kazuya Takehana, Yasuyo Taniguchi, Hiroki Teragawa, Nobuo Tomizawa, Kyoko Umeji, Yasushi Wakabayashi, Shinichiro Yamada, Shinya Yamazaki, Tatsuya Yoneyama, Mohammad Rawashdeh, Tairkhan Dautov, Khalid Makhdomi, Mostafa Abass, Masoud Garashi, Qaisar Siraj, Marika Kalnina, Mohamad Haidar, Renata Komiagiene, Giedre Kviecinskiene, Donatas Vajauskas, Noor Khairiah A. Karim, Mady Doucoure, Luise Reichmuth, Anthony Samuel, Mohamed Lemine Dieng, Ambedhkar Shantaram Naojee, Estrella Aguilera Hernandez, Cesar Rene Alducin Tellez, Erick Alexánderson-Rosas, Erika Barragan, Manuel Cabada, Daniel Calderón, Isabel Carvajal-Juarez, José Esparza, Manlio Gerardo Gama-Moreno, Virginia Garcia Quinto, Nelsy Coromoto Gonzalez, Mary Carmen Herrera-Zarza, Aloha Meave, Jesus Gregorio Medina Verdugo, Gabriela Melendez, Rafael Humberto Morales Murguia, Carlos Salvador Navarro Quiroz, Mario Ornelas, Andres Preciado-Anaya, Oscar Ulises Preciado-Gutiérrez, Adriana Puente, Aristóteles Ramírez Salazar, Sandra Graciela Rosales Uvera, Sandra Rosales-Uvera, Jose Antonio Serna Macias, Lilia Sierra-Galan, Lilia M. Sierra-Galan, Juan Carlos Tirado Alderete, Enrique Vallejo, Marc Faraggi, Erdenechimeg Sereegotov, Nouzha Ben Rais, Nadia Ismaili Alaoui, Thiri Kyiphyu, Su Thet Oo, Soe Myat Win, Htin Zar, Ram Ghimire, Madhu Neupane, Andor Glaudemans, Riemer Slart, Derk Verschure, Berry Allen, John Edmond, Clare Mckenzie, Stuart Tie, Niels Van Pelt, Kirsten Worthington, Calum Young, Idrissa Adamou Soli, Shehu Kana, Uchenna Onubogu, Mahmoud Sani, Anders Tjellaug Bråten, Arve Jørgensen, Hanne-Elin Vassbotn, Humoud Al Dhuhli, Zabah Jawa, Naima Tag, Shazia Fatima, Muhammad Babar Imran, Muhammad Numair Younis, Mohammad Saadullah, Yariela Herrera Malo, Dora Lenturut-Katal, Manuel Castillo, José Ortellado, Afroza Akhter, F. Aaysha Cader, Raihan Hussain, Saidur Rahman Khan, Tapati Mandal, Faria Nasreen, Yunqiang An, Dianbo Cao, Lianggeng Gong, Yang Hou, Chongfu Jia, Tao Li, Caiying Li, Hui Liu, Wenya Liu, Jinkang Liu, Ming-Yen Ng, Heshui Shi, Chunxiang Tang, Ximing Wang, Zhaoqian Wang, Yining Wang, Jiang Wu, Yan Yi, Li Yuan, Tong Zhang, Longjiang Zhang, Edith Chavez, Carlos Cruz, Christian Llontop, Rosanna Morales, Paz Abrihan, Asela Bustos-Barroso, Michele Duldulao-Ogbac, Christopher Eduarte, Jerry Obaldo, Alvin Quinon, Belinda San Juan, Carlo Joe San Juan, Marie Rhiamar Sauler-Gomez, Mila Uy, Magdalena Kostkiewicz, Jolanta Kunikowska, Anna Teresinska, Tomasz Urbanik, Nuno Bettencourt, Ricardo Fontes-Carvalho, Cristina Gavina, Lino Gonçalves, Filipe Macedo, Nuno Moreno, Carla Sousa, Ana Teresa Timoteo, Maria João Vidigal, Mahmoud Al Heidous, Subramaniyan Ramanathan, Samer Arnous, Said Aytani, Angela Byrne, Tadhg Gleeson, David Kerins, Julie O'Brien, Ji-In Bang, Henry Bom, Miju Cheon, Gi Jeong Cheon, Sang-Geon Cho, Chae Moon Hong, Yong Hyu Jeong, Won Jun Kang, Yeon-Koo Kang, Ji-Young Kim, So Won Oh, Young So, Ho-Chun Song, Kyoung Sook Won, Soo Woong Yoo, Irena Mitevska, Marija Vavlukis, Barbara Gužic Salobir, Monika Štalc, Theodora Benedek, Marian Pop, Claudiu Stan, Alexey Ansheles, Olga Dariy, Nina Gagarina, Irina Itskovich, Anatoliy Karalkin, Alexander Kokov, Gulya Marina, Ekaterina Migunova, Viktor Pospelov, Daria Ryzhkova, Guzaliya Sayfullina, Vladimir Sergienko, Irina Shurupova, Margarita Vakhromeeva, Nailia Valiullina, Konstantin Zavadovsky, Kirill Zhuravlev, Rami Abazid, Turki Al Garni, Mirvat Alasnag, Ahmed Aljizeeri, Hamid Amer, Ahmad Amro, Hesham Hamdy, Osama Smettei, Dragana Sobic Saranovic, Marina Vlajkovic, Felix Keng, Jason See, Zuzana Berecova, Jana Polakova Mistinova, Osayande Evbuomwan, Nerisha Govender, Jonathan Hack, Bawinile Hadebe, Khanyisile Hlongwa, Mitchell Kaplan, Hoosen Lakhi, Katarina Milos, Moshe Modiselle, Stuart More, Ntanganedzeni Muambadzi, Leonie Scholtz, Manuel Barreiro-Perez, Isabel Blanco, Jordi Broncano, Alicia Camarero, Irene Casáns-Tormo, Javier De Haro, Albert Flotats, Elia García, Ceferino Gutierrez Mendiguchia, Amelia Jimenez-Heffernan, Ruben Leta, Javier Lopez Diaz, Luis Lumbreras Vega, Ana Manovel-Sánchez, Amparo Martinez Monzonis, Bianca Patrut, Virginia Pubul, Ricardo Ruano Perez, Nahla Zeidan, Damayanthi Nanayakkara, Ahmed Suliman, Henrik Engblom, Mustafa Murtadha, Ellen Ostenfeld, Magnus Simonsson, Hatem Alkadhi, Ronny Ralf Buechel, Peter Burger, Christoph Gräni, Christel Kamani, Nadine Kawel-Böhm, Bernd Klaeser, Robert Manka, John Prior, Tawika Kaewchur, Benjapa Khiewvan, Arpakorn Kositwattanarerk, Sirianong Namwongprom, Tanyaluck Thientunyakit, Haluk Burcak Sayman, Mahmut Yüksel, Mugisha Julius Sebikali, Emmy Okello, Pavlo Korol, Iryna Noverko, Maryna Satyr, Tahir Ahmad, Khaled Alfakih, Ivo Andrade, Susan Buckingham, Anda Bularga, John-Paul Carpenter, Graham Cole, David Cusack, Sarojini David, Patrick Davis, Timothy Fairbairn, Arjun Ghosh, Prasad Guntur Ramkumar, Mark Hamilton, Faisal Haque, Benjamin Hudson, Annette Johnstone, V.J. Karthikeyan, Mike Kay, Mohammad Ali Khan, Jamie Kitt, Chen Sheng Low, Elisa Mcalindon, David Mccreavy, Brian Morrissey, Manish Motwani, Dilip Na, Edward Nicol, Dilip Patel, Jonathan Rodrigues, Chris Rofe, Rebecca Schofield, Thomas Semple, Azeem Sheikh, Apurva Sinha, Deepak Subedi, William Topping, Katherine Tweed, Stephen Richard Underwood, Jonathan Weir-Mccall, Hamed Zuhairy, Taimur Abbasi, Shady Abohashem, Sandra Abramson, Mouaz Al-Mallah, Mohan Ashok Kumar, Mallory Balmer-Swain, Daniel Berman, Adam Bernheim, Sabha Bhatti, Robert Biederman, Erik Bieging, Scott Bingham, Stephen Bloom, Sean Blue, Andressa Borges, Kelley Branch, Paco Bravo, Sujatha Buddhe, Matthew Budoff, Renée Bullock-Palmer, Michael Cahill, Candace Candela, Jane Cao, Saurav Chatterjee, Yiannis Chatzizisis, Nita Ray Chaudhuri, Michael Cheezum, Anjali Chelliah, Tiffany Chen, Marcus Chen, Lu Chen, Aalap Chokshi, Jina Chung, Sorin Danciu, William DeSisto, Michael Dilorenzo, Rami Doukky, William Duvall, Maros Ferencik, Cameron Foster, Anthon Fuisz, Michael Gannon, David German, Myron Gerson, Jeffrey Geske, Fadi Hage, Agha Haider, Sofia Haider, Yasmin Hamirani, Karen Hassen, Robert Hendel, Jacqueline Henkel, Stephen Horgan, Mark Hyun, Rajesh Janardhanan, Scott Jerome, Dinesh Kalra, David Kassop, Mona Kinkhabwala, George Kinzfogl, Bernard Koch, Lynne Koweek, Joseph Krepp, Younghoon Kwon, Jay Layer, John Lesser, Steve Leung, Bernadette Lisske, Kathleen Magurany, Jeremy Markowitz, Brenda Mccullough, Azita Moalemi, Chanan Moffitt, Juan Montanez, Warren Moore, Shamil Morayati, Mahmud Mossa-Basha, Zorana Mrsic, Venkatesh Murthy, Prashant Nagpal, Katarina Nelson, Prabhjot Nijjar, Rupal O’Quinn, Edward Passen, Toral Patel, Pravin Patil, Amit Pursnani, Nancy Quachang, Mark Rabbat, Pragya Ranjan, Patricia Rodriguez Lozano, Mary Schemmer, Rebecca Seifried, Nishant Shah, Amee Shah, Sujata Shanbhag, Gaurav Sharma, Robert Skotnicki, Michael Sobczak, Prem Soman, Vincent Sorrell, Monvadi Srichai, Jim Streeter, Leah Strickland, Suliman Suliman, Naghmeh Tebyanian, Dustin Thomas, Randall Thompson, Seth Uretsky, Srikanth Vallurupalli, Marian Vandyck-Acquah, Vikas Verma, Todd Villines, Joseph Weinstein, David Wolinsky, Karolina Zareba, Michael Zgaljardic, Mario Beretta, Rodolfo Ferrando, Miguel Kapitan, Fernando Mut, Omoa Djuraev, Gulnora Rozikhodjaeva, Luisa Vera, Binh Duong Duc, Xuan Canh Nguyen, Phuoc Minh Hiep Nguyen, Translational Immunology Groningen (TRIGR), Cardiovascular Centre (CVC), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Molecular Pharmacology, Drug Design, Einstein, A, Hirschfeld, C, Williams, M, Vitola, J, Better, N, Villines, T, Cerci, R, Shaw, L, Choi, A, Dorbala, S, Karthikeyan, G, Lu, B, Sinitsyn, V, Ansheles, A, Kudo, T, Bucciarelli-Ducci, C, Norgaard, B, Maurovich-Horvat, P, Campisi, R, Milan, E, Louw, L, Allam, A, Bhatia, M, Sewanan, L, Malkovskiy, E, Cohen, Y, Randazzo, M, Narula, J, Morozova, O, Pascual, T, Pynda, Y, Dondi, M, Paez, D, Hinterleitner, G, Lu, Y, Xu, Z, Erinne, I, Shetty, M, Lopez-Mattei, J, Parwani, P, Goda, A, Shirka, E, Bouyoucef, S, Chelghoum, L, Mansouri, F, Medjahedi, A, Naili, Q, Ridouh, M, Alasia, D, Alberghina, L, Aramayo, N, Buchara, D, Busso, F, Bustos Rivadero, J, Camilletti, J, Campanelli, H, Castro, R, Daicz, M, del Riego, H, Dragonetti, L, Echazarreta, D, Erriest, J, Faccio, F, Facello, A, Gallegos, H, Geronazzo, R, Glait, H, Hasbani, V, Jager, V, Lewkowicz, J, Lotti, J, Maciel, N, Masoli, O, Mastrovito, E, Medus, M, Merani, M, Molteni, S, Montecinos, M, Parisi, G, Sueldo, C, Perez de Arenaza, D, Quintana, L, Radzinschi, A, Redruello, M, Rodriguez, M, Rojas, H, Acuna, A, Schere, D, Traverso, S, Vazquez, G, Zeffiro, S, Sakanyan, M, Beuzeville, S, Boktor, R, Crowley, M, Downie, D, Dwivedi, G, Elison, B, Farouque, O, Jasper, K, Joshi, S, Lee, J, Lee, K, Lui, E, Mcconachie, P, Meaker, J, Nandurkar, D, Neill, J, O'Rourke, E, O'Sullivan, P, Pandos, G, Premaratne, M, Prior, D, Rutherford, N, Saunders, C, Taubman, K, Tauro, A, Taylor, A, Theuerle, J, Thomas, P, Tow, J, Upton, A, Vamadevan, S, Wayne, V, Wegner, E, Wong, D, Younger, J, Beitzke, D, Feuchtner, G, Sommer, O, Weiss, K, Maroz-Vadalazhskaya, N, Tserakhau, U, Homans, F, Van De Heyning, C, Araujo, R, Soldat-Stankovic, V, Stankovic, S, Almeida, A, Anselmi, C, Azevedo, G, Bittencourt, M, Pianta, D, Cabeda, E, Carreira, L, Coelho, I, de Amorim Fernandes, F, de Lorenzo, A, Delgado, R, Erthal, F, Fernandes, F, Fernandes, J, Ferreira de Souza, T, Foppa, M, Matos Alves, W, Gontijo, C, Gottlieb, I, Grossman, G, Albernaz Siqueira, M, Nomura, C, Koga, K, Lima, R, Lopes, R, Marcal Filho, H, Masiero, P, Mastrocola, L, Menezes de Siqueira, M, Mesquita, C, Naves, D, Penna, F, Pinto, I, Rocha, T, Rocha, J, Rodrigues, A, Salioni, L, Sanches, A, Santos, M, Da Silva, L, Schvartzman, P, Matushita, C, Senra, T, Silva, M, Soares, C, Spiro, B, Suaide Silva, C, Torres, R, Monte, G, Vilela, A, Villa, A, Voss, T, Waltrick, R, Zapparoli, M, Naseer, H, Garcheva-Tsacheva, M, Ouattara, T, Thou, S, Varoeun, S, Abikhzer, G, Beanlands, R, Chetrit, M, Dabreo, D, Dennie, C, Friedrich, M, Hafez, M, Hanneman, K, Miller, R, Oikonomou, A, Roifman, I, Small, G, Tandon, V, Trivedi, A, White, J, Zukotynski, K, Alay, R, Concha, C, Massardo, T, Abad, P, Anzola, K, Arturo, H, Benitez, L, Cadena, A, Zamudio, C, Calderon, A, Gutierrez Villamil, C, Jaimes, C, Londono, J, Lopez, N, Merlano-Gaitan, S, Murgieitio-Cabrera, R, Valencia, M, Vergel, D, Santamaria, A, Solis, F, Batinic, T, Franceschi, M, Paar, M, Prpic, M, Felipe Batista, C, Cabrera, L, Peix, A, Pena, Y, Rochela Vazquez, L, Ntalas, I, Kaminek, M, Kincl, V, Lang, O, Abdulla, J, Bottcher, M, Busk, M, Geisler, U, Gormsen, L, Hansson, N, Hess, S, Hove, J, Jensen, L, Jensen, M, Kragholm, K, Ovrehus, K, Rasmussen, J, Ronnow Sand, N, Sondergaard, H, Zaremba, T, Speckter, H, Amores, N, Velez, M, Alrahman, T, Elsamad, S, Abdelfattah, A, Elkaffas, S, Hassan, M, Hussein, E, Ibrahim, A, Kandeel, A, Ali, M, Shaaban, M, Flores, C, Gomez Leiva, V, Liiver, A, Larikka, M, Uusitalo, V, Agostini, D, Berger, C, Dietz, M, Hyafil, F, Ohana, M, Prigent, K, Regaieg, H, Sarda-Mantel, L, H-Ici, D, Ayetey, H, Angelidis, G, Fragkaki, C, Fragkiadaki, C, Georgoulias, P, Koutelou, M, Kyrozi, E, Lama, N, Prassopoulos, V, Spartalis, M, Zaglavara, T, Gonzalez, C, Gutierrez, G, Maldonado, A, Martinez, Y, Kovacs, A, Szilveszter, B, Banthia, N, Bhat, V, Choudhury, P, Chowdekar, V, Christopher, J, Garg, T, Goyal, N, Gupta, R, Gupta, A, Hephzibah, J, Jain, S, Krupa, J, Kumar, P, Kumar, S, Lalchandani, A, Mishra, A, Mishra, V, Mohan, P, Ozair, A, Pandey, S, Parameswaran, R, Patel, C, Patel, T, Patel, S, Vimala, L, Kumar Sarangi, D, Sengupta, S, Sethi, A, Sharma, A, Sharma, P, Shrigiriwar, A, Singh, S, Singh, H, Sood, A, Verma, A, Vyas, A, Soeriadi, E, Bun, E, Hutomo, F, Syawaluddin, H, Yudistiro, R, Albadr, A, Assadi, M, Emami, F, Emami-Ardekani, A, Farzanehfar, S, Jafari, R, Manafi-Farid, R, Tajik, M, Arnson, Y, Fuchs, S, Goldkorn, R, Kennedy, J, Leitman, M, Shalev, A, Acampa, W, Albano, D, Alongi, P, Arnone, G, Assante, R, Baritussio, A, Bauckneht, M, Bianco, F, Bonfiglioli, R, Bovenzi, F, Bruno, I, Bruno, A, Busnardo, E, Califaretti, E, Casoni, R, Censullo, V, Chierichetti, F, Chiocchi, M, Cittanti, C, Clemente, A, Cuocolo, A, De Rimini, M, De Vincentis, G, Della Tommasina, V, Dellegrottaglie, S, Erba, P, Evangelista, L, Faggi, L, Faragasso, E, Florimonte, L, Frantellizzi, V, Gatti, M, Gaudiano, A, Gelardi, F, Gerali, A, Gimelli, A, Guglielmo, M, Leccisotti, L, Liga, R, Liguori, C, Longo, G, Maffione, M, Marcassa, C, Matassa, G, Mele, D, Mircoli, L, Paccagnella, A, Pacella, S, Padovano, F, Pellegrini, D, Pergola, V, Pugliese, L, Quartuccio, N, Rampin, L, Ricci, F, Rubini, G, Russo, V, Sambuceti, G, Scatteia, A, Sciagra, R, Spidalieri, G, Stefanelli, A, Tedeschi, C, Ventroni, G, Baugh, D, Madu, E, Aikawa, T, Asano, H, Fujimoto, S, Fujise, K, Fukushima, Y, Fukuyama, K, Ichikawa, Y, Ideguchi, R, Iguchi, N, Imai, M, Ishimura, H, Isobe, S, Ito, K, Izawa, Y, Kadokami, T, Kasai, T, Kato, T, Kawamoto, T, Kiryu, S, Kumita, S, Manabe, O, Maruno, H, Matsumoto, N, Miyagawa, M, Moroi, M, Nagamachi, S, Nakajima, K, Nakazato, R, Nanasato, M, Naya, M, Norikane, T, Ohta, Y, Otomi, Y, Otsuka, H, Oyama-Manabe, N, Saito, M, Sarai, M, Sato, J, Sato, D, Shiraishi, S, Takanami, K, Takehana, K, Taniguchi, Y, Teragawa, H, Tomizawa, N, Umeji, K, Wakabayashi, Y, Yamada, S, Yamazaki, S, Yoneyama, T, Rawashdeh, M, Dautov, T, Makhdomi, K, Abass, M, Garashi, M, Siraj, Q, Kalnina, M, Haidar, M, Komiagiene, R, Kviecinskiene, G, Vajauskas, D, Karim, N, Doucoure, M, Reichmuth, L, Samuel, A, Dieng, M, Naojee, A, Hernandez, E, Alducin Tellez, C, Alexanderson-Rosas, E, Barragan, E, Cabada, M, Calderon, D, Carvajal-Juarez, I, Esparza, J, Gama-Moreno, M, Quinto, V, Gonzalez, N, Herrera-Zarza, M, Meave, A, Medina Verdugo, J, Melendez, G, Morales Murguia, R, Navarro Quiroz, C, Ornelas, M, Preciado-Anaya, A, Preciado-Gutierrez, O, Puente, A, Salazar, A, Rosales Uvera, S, Rosales-Uvera, S, Serna Macias, J, Sierra-Galan, L, Tirado Alderete, J, Vallejo, E, Faraggi, M, Sereegotov, E, Ben Rais, N, Alaoui, N, Kyiphyu, T, Oo, S, Win, S, Zar, H, Ghimire, R, Neupane, M, Glaudemans, A, Slart, R, Verschure, D, Allen, B, Edmond, J, Mckenzie, C, Tie, S, Van Pelt, N, Worthington, K, Young, C, Soli, I, Kana, S, Onubogu, U, Sani, M, Braten, A, Jorgensen, A, Vassbotn, H, Al Dhuhli, H, Jawa, Z, Tag, N, Fatima, S, Imran, M, Younis, M, Saadullah, M, Malo, Y, Lenturut-Katal, D, Castillo, M, Ortellado, J, Akhter, A, Cader, F, Hussain, R, Khan, S, Mandal, T, Nasreen, F, An, Y, Cao, D, Gong, L, Hou, Y, Jia, C, Li, T, Li, C, Liu, H, Liu, W, Liu, J, Ng, M, Shi, H, Tang, C, Wang, X, Wang, Z, Wang, Y, Wu, J, Yi, Y, Yuan, L, Zhang, T, Zhang, L, Chavez, E, Cruz, C, Llontop, C, Morales, R, Abrihan, P, Bustos-Barroso, A, Duldulao-Ogbac, M, Eduarte, C, Obaldo, J, Quinon, A, San Juan, B, San Juan, C, Sauler-Gomez, M, Uy, M, Kostkiewicz, M, Kunikowska, J, Teresinska, A, Urbanik, T, Bettencourt, N, Fontes-Carvalho, R, Gavina, C, Goncalves, L, Macedo, F, Moreno, N, Sousa, C, Timoteo, A, Vidigal, M, Al Heidous, M, Ramanathan, S, Arnous, S, Aytani, S, Byrne, A, Gleeson, T, Kerins, D, O'Brien, J, Bang, J, Bom, H, Cheon, M, Cheon, G, Cho, S, Hong, C, Jeong, Y, Kang, W, Kang, Y, Kim, J, Oh, S, So, Y, Song, H, Won, K, Yoo, S, Mitevska, I, Vavlukis, M, Salobir, B, Stalc, M, Benedek, T, Pop, M, Stan, C, Dariy, O, Gagarina, N, Itskovich, I, Karalkin, A, Kokov, A, Marina, G, Migunova, E, Pospelov, V, Ryzhkova, D, Sayfullina, G, Sergienko, V, Shurupova, I, Vakhromeeva, M, Valiullina, N, Zavadovsky, K, Zhuravlev, K, Abazid, R, Al Garni, T, Alasnag, M, Aljizeeri, A, Amer, H, Amro, A, Hamdy, H, Smettei, O, Saranovic, D, Vlajkovic, M, Keng, F, See, J, Berecova, Z, Mistinova, J, Evbuomwan, O, Govender, N, Hack, J, Hadebe, B, Hlongwa, K, Kaplan, M, Lakhi, H, Milos, K, Modiselle, M, More, S, Muambadzi, N, Scholtz, L, Barreiro-Perez, M, Blanco, I, Broncano, J, Camarero, A, Casans-Tormo, I, De Haro, J, Flotats, A, Garcia, E, Mendiguchia, C, Jimenez-Heffernan, A, Leta, R, Diaz, J, Vega, L, Manovel-Sanchez, A, Monzonis, A, Patrut, B, Pubul, V, Perez, R, Zeidan, N, Nanayakkara, D, Suliman, A, Engblom, H, Murtadha, M, Ostenfeld, E, Simonsson, M, Alkadhi, H, Buechel, R, Burger, P, Grani, C, Kamani, C, Kawel-Bohm, N, Klaeser, B, Manka, R, Prior, J, Kaewchur, T, Khiewvan, B, Kositwattanarerk, A, Namwongprom, S, Thientunyakit, T, Sayman, H, Yuksel, M, Sebikali, M, Okello, E, Korol, P, Noverko, I, Satyr, M, Ahmad, T, Alfakih, K, Andrade, I, Buckingham, S, Bularga, A, Carpenter, J, Cole, G, Cusack, D, David, S, Davis, P, Fairbairn, T, Ghosh, A, Ramkumar, P, Hamilton, M, Haque, F, Hudson, B, Johnstone, A, Karthikeyan, V, Kay, M, Khan, M, Kitt, J, Low, C, Mcalindon, E, Mccreavy, D, Morrissey, B, Motwani, M, Na, D, Nicol, E, Patel, D, Rodrigues, J, Rofe, C, Schofield, R, Semple, T, Sheikh, A, Sinha, A, Subedi, D, Topping, W, Tweed, K, Underwood, S, Weir-Mccall, J, Zuhairy, H, Abbasi, T, Abohashem, S, Abramson, S, Al-Mallah, M, Kumar, M, Balmer-Swain, M, Berman, D, Bernheim, A, Bhatti, S, Biederman, R, Bieging, E, Bingham, S, Bloom, S, Blue, S, Borges, A, Branch, K, Bravo, P, Buddhe, S, Budoff, M, Bullock-Palmer, R, Cahill, M, Candela, C, Cao, J, Chatterjee, S, Chatzizisis, Y, Chaudhuri, N, Cheezum, M, Chelliah, A, Chen, T, Chen, M, Chen, L, Chokshi, A, Chung, J, Danciu, S, Desisto, W, Dilorenzo, M, Doukky, R, Duvall, W, Ferencik, M, Foster, C, Fuisz, A, Gannon, M, German, D, Gerson, M, Geske, J, Hage, F, Haider, A, Haider, S, Hamirani, Y, Hassen, K, Hendel, R, Henkel, J, Horgan, S, Hyun, M, Janardhanan, R, Jerome, S, Kalra, D, Kassop, D, Kinkhabwala, M, Kinzfogl, G, Koch, B, Koweek, L, Krepp, J, Kwon, Y, Layer, J, Lesser, J, Leung, S, Lisske, B, Magurany, K, Markowitz, J, Mccullough, B, Moalemi, A, Moffitt, C, Montanez, J, Moore, W, Morayati, S, Mossa-Basha, M, Mrsic, Z, Murthy, V, Nagpal, P, Nelson, K, Nijjar, P, O'Quinn, R, Passen, E, Patil, P, Pursnani, A, Quachang, N, Rabbat, M, Ranjan, P, Lozano, P, Schemmer, M, Seifried, R, Shah, N, Shah, A, Shanbhag, S, Sharma, G, Skotnicki, R, Sobczak, M, Soman, P, Sorrell, V, Srichai, M, Streeter, J, Strickland, L, Suliman, S, Tebyanian, N, Thomas, D, Thompson, R, Uretsky, S, Vallurupalli, S, Vandyck-Acquah, M, Verma, V, Weinstein, J, Wolinsky, D, Zareba, K, Zgaljardic, M, Beretta, M, Ferrando, R, Kapitan, M, Mut, F, Djuraev, O, Rozikhodjaeva, G, Vera, L, Duc, B, Nguyen, X, Hiep Nguyen, P, Einstein, Andrew J, Hirschfeld, Cole, Williams, Michelle C, Vitola, Joao V, Better, Nathan, Villines, Todd C, Cerci, Rodrigo, Shaw, Leslee J, Choi, Andrew D, Dorbala, Sharmila, Karthikeyan, Ganesan, Lu, Bin, Sinitsyn, Valentin, Ansheles, Alexey A, Kudo, Takashi, Bucciarelli-Ducci, Chiara, Nørgaard, Bjarne Linde, Maurovich-Horvat, Pál, Campisi, Roxana, Milan, Elisa, Louw, Lizette, Allam, Adel H, Bhatia, Mona, Sewanan, Lorenzo, Malkovskiy, Eli, Cohen, Yosef, Randazzo, Michael, Narula, Jagat, Morozova, Olga, Pascual, Thomas N B, Pynda, Yaroslav, Dondi, Maurizio, Paez, Diana, and Cuocolo, Alberto

Subjects
cardiac testing, Health Personnel, delivery of health care, coronavirus, COVID-19, global health, 610 Medicine & health, cardiovascular disease, health personnel, humans, pandemics, surveys and questionnaires, coronaviru, Surveys and Questionnaires, Humans, Cardiology and Cardiovascular Medicine, Delivery of Health Care, Pandemics, COVID-19/epidemiology
Abstract

BACKGROUND: The extent to which health care systems have adapted to the COVID-19 pandemic to provide necessary cardiac diagnostic services is unknown.OBJECTIVES: The aim of this study was to determine the impact of the pandemic on cardiac testing practices, volumes and types of diagnostic services, and perceived psychological stress to health care providers worldwide.METHODS: The International Atomic Energy Agency conducted a worldwide survey assessing alterations from baseline in cardiovascular diagnostic care at the pandemic's onset and 1 year later. Multivariable regression was used to determine factors associated with procedure volume recovery.RESULTS: Surveys were submitted from 669 centers in 107 countries. Worldwide reduction in cardiac procedure volumes of 64% from March 2019 to April 2020 recovered by April 2021 in high- and upper middle-income countries (recovery rates of 108% and 99%) but remained depressed in lower middle- and low-income countries (46% and 30% recovery). Although stress testing was used 12% less frequently in 2021 than in 2019, coronary computed tomographic angiography was used 14% more, a trend also seen for other advanced cardiac imaging modalities (positron emission tomography and magnetic resonance; 22%-25% increases). Pandemic-related psychological stress was estimated to have affected nearly 40% of staff, impacting patient care at 78% of sites. In multivariable regression, only lower-income status and physicians' psychological stress were significant in predicting recovery of cardiac testing.CONCLUSIONS: Cardiac diagnostic testing has yet to recover to prepandemic levels in lower-income countries. Worldwide, the decrease in standard stress testing is offset by greater use of advanced cardiac imaging modalities. Pandemic-related psychological stress among providers is widespread and associated with poor recovery of cardiac testing.

Published
2022

135. Impact of COVID-19 Pandemic on Cardiovascular Testing in Asia

Author

Takashi Kudo, Ryan Lahey, Cole B. Hirschfeld, Michelle C. Williams, Bin Lu, Mirvat Alasnag, Mona Bhatia, Hee-Seung Henry Bom, Tairkhan Dautov, Reza Fazel, Ganesan Karthikeyan, Felix Y.J. Keng, Ronen Rubinshtein, Nathan Better, Rodrigo Julio Cerci, Sharmila Dorbala, Paolo Raggi, Leslee J. Shaw, Todd C. Villines, João V. Vitola, Andrew D. Choi, Eli Malkovskiy, Benjamin Goebel, Yosef A. Cohen, Michael Randazzo, Thomas N.B. Pascual, Yaroslav Pynda, Maurizio Dondi, Diana Paez, Andrew J. Einstein, Rodrigo Cerci, Joao V. Vitola, Gerd Hinterleitner, Yao Lu, Olga Morozova, Zhuoran Xu, Yosef Cohen, Andrew Choi, Juan Lopez-Mattei, Purvi Parwani, Mohammad Nawaz Nasery, Artan Goda, Ervina Shirka, Rabie Benlabgaa, Salah Bouyoucef, Abdelkader Medjahedi, Qais Nailli, Mariela Agolti, Roberto Nicolas Aguero, Maria del Carmen Alak, Lucia Graciela Alberguina, Guillermo Arroñada, Andrea Astesiano, Alfredo Astesiano, Carolina Bas Norton, Pablo Benteo, Juan Blanco, Juan Manuel Bonelli, Jose Javier Bustos, Raul Cabrejas, Jorge Cachero, Roxana Campisi, Alejandro Canderoli, Silvia Carames, Patrícia Carrascosa, Ricardo Castro, Oscar Cendoya, Luciano Martin Cognigni, Carlos Collaud, Claudia Cortes, Javier Courtis, Daniel Cragnolino, Mariana Daicz, Alejandro De La Vega, Silvia Teresa De Maria, Horacio Del Riego, Fernando Dettori, Alejandro Deviggiano, Laura Dragonetti, Mario Embon, Ruben Emilio Enriquez, Jorge Ensinas, Fernando Faccio, Adolfo Facello, Diego Garofalo, Ricardo Geronazzo, Natalia Gonza, Lucas Gutierrez, Miguel Angel Guzzo, Victor Hasbani, Melina Huerin, Victor Jäger, Julio Manuel Lewkowicz, Maria Nieves A. López De Munaín, Jose Maria Lotti, Alejandra Marquez, Osvaldo Masoli, Osvaldo Horacio Masoli, Edgardo Mastrovito, Matias Mayoraz, Graciela Eva Melado, Anibal Mele, Maria Fernanda Merani, Alejandro Horacio Meretta, Susana Molteni, Marcos Montecinos, Eduardo Noguera, Carlos Novoa, Claudio Pereyra Sueldo, Sebastian Perez Ascani, Pablo Pollono, Maria Paula Pujol, Alejandro Radzinschi, Gustavo Raimondi, Marcela Redruello, Marina Rodríguez, Matías Rodríguez, Romina Lorena Romero, Arturo Romero Acuña, Federico Rovaletti, Lucas San Miguel, Lucrecia Solari, Bruno Strada, Sonia Traverso, Sonia Simona Traverzo, Maria del Huerto Velazquez Espeche, Juan Sebastian Weihmuller, Juan Wolcan, Susana Zeffiro, Mari Sakanyan, Scott Beuzeville, Raef Boktor, Patrick Butler, Jennifer Calcott, Loretta Carr, Virgil Chan, Charles Chao, Woon Chong, Mark Dobson, D'Arne Downie, Girish Dwivedi, Barry Elison, Jean Engela, Roslyn Francis, Anand Gaikwad, Ashok Gangasandra Basavaraj, Bruce Goodwin, Robert Greenough, Christian Hamilton-Craig, Victar Hsieh, Subodh Joshi, Karin Lederer, Kenneth Lee, Joseph Lee, John Magnussen, Nghi Mai, Gordon Mander, Fiona Murton, Dee Nandurkar, Johanne Neill, Edward O'Rourke, Patricia O'Sullivan, George Pandos, Kunthi Pathmaraj, Alexander Pitman, Rohan Poulter, Manuja Premaratne, David Prior, Lloyd Ridley, Natalie Rutherford, Hamid Salehi, Connor Saunders, Luke Scarlett, Sujith Seneviratne, Deepa Shetty, Ganesh Shrestha, Jonathan Shulman, Vijay Solanki, Tony Stanton, Murch Stuart, Michael Stubbs, Ian Swainson, Kim Taubman, Andrew Taylor, Paul Thomas, Steven Unger, Anthony Upton, Shankar Vamadevan, William Van Gaal, Johan Verjans, Demetrius Voutnis, Victor Wayne, Peter Wilson, David Wong, Kirby Wong, John Younger, Gudrun Feuchtner, Siroos Mirzaei, Konrad Weiss, Natallia Maroz-Vadalazhskaya, Olivier Gheysens, Filip Homans, Rodrigo Moreno-Reyes, Agnès Pasquet, Veronique Roelants, Caroline M. Van De Heyning, Raúl Araujo Ríos, Valentina Soldat-Stankovic, Sinisa Stankovic, Maria Helena Albernaz Siqueira, Augusto Almeida, Paulo Henrique Alves Togni, Jose Henrique Andrade, Luciana Andrade, Carlos Anselmi, Roberta Araújo, Guilherme Azevedo, Sabbrina Bezerra, Rodrigo Biancardi, Gabriel Blacher Grossman, Simone Brandão, Diego Bromfman Pianta, Lara Carreira, Bruno Castro, Tien Chang, Fernando Cunali, Roberto Cury, Roberto Dantas, Fernando de Amorim Fernandes, Andrea De Lorenzo, Robson De Macedo Filho, Fernanda Erthal, Fabio Fernandes, Juliano Fernandes, Thiago Ferreira De Souza, Wilson Furlan Alves, Bruno Ghini, Luiz Goncalves, Ilan Gottlieb, Marcelo Hadlich, Vinícius Kameoka, Ronaldo Lima, Adna Lima, Rafael Willain Lopes, Ricardo Machado e Silva, Tiago Magalhães, Fábio Martins Silva, Luiz Eduardo Mastrocola, Fábio Medeiros, José Claudio Meneghetti, Vania Naue, Danilo Naves, Roberto Nolasco, Cesar Nomura, Joao Bruno Oliveira, Eduardo Paixao, Filipe Penna De Carvalho, Ibraim Pinto, Priscila Possetti, Mayra Quinta, Rodrigo Rizzo Nogueira Ramos, Ricardo Rocha, Alfredo Rodrigues, Carlos Rodrigues, Leila Romantini, Adelina Sanches, Sara Santana, Leonardo Sara da Silva, Paulo Schvartzman, Cristina Sebastião Matushita, Tiago Senra, Afonso Shiozaki, Maria Eduarda Menezes de Siqueira, Cristiano Siqueira, Paola Smanio, Carlos Eduardo Soares, José Soares Junior, Marcio Sommer Bittencourt, Bernardo Spiro, Cláudio Tinoco Mesquita, Jorge Torreao, Rafael Torres, Marly Uellendahl, Guilherme Urpia Monte, Otávia Veríssimo, Estevan Vieira Cabeda, Felipe Villela Pedras, Roberto Waltrick, Marcello Zapparoli, Hamid Naseer, Marina Garcheva-Tsacheva, Irena Kostadinova, Youdaline Theng, Gad Abikhzer, Rene Barette, Benjamin Chow, Dominique Dabreo, Matthias Friedrich, Ria Garg, Mohammed Nassoh Hafez, Chris Johnson, Marla Kiess, Jonathon Leipsic, Eugene Leung, Robert Miller, Anastasia Oikonomou, Stephan Probst, Idan Roifman, Gary Small, Vikas Tandon, Adwait Trivedi, James White, Katherine Zukotynski, Jose Canessa, Gabriel Castro Muñoz, Carmen Concha, Pablo Hidalgo, Cesar Lovera, Teresa Massardo, Luis Salazar Vargas, Pedro Abad, Harold Arturo, Sandra Ayala, Luis Benitez, Alberto Cadena, Carlos Caicedo, Antonio Calderón Moncayo, Sharon Gomez, Claudia T. Gutierrez Villamil, Claudia Jaimes, Juan Londoño, Juan Luis Londoño Blair, Luz Pabon, Mauricio Pineda, Juan Carlos Rojas, Diego Ruiz, Manuel Valencia Escobar, Andres Vasquez, Damiana Vergel, Alejandro Zuluaga, Isabel Berrocal Gamboa, Gabriel Castro, Ulises González, Ana Baric, Tonci Batinic, Maja Franceschi, Maja Hrabak Paar, Mladen Jukic, Petar Medakovic, Viktor Persic, Marina Prpic, Ante Punda, Juan Felipe Batista, Juan Manuel Gómez Lauchy, Yamile Marcos Gutierrez, Rayner Menéndez, Amalia Peix, Luis Rochela, Christoforos Panagidis, Ioannis Petrou, Vaclav Engelmann, Milan Kaminek, Vladimír Kincl, Otto Lang, Milan Simanek, Jawdat Abdulla, Morten Bøttcher, Mette Christensen, Lars Christian Gormsen, Philip Hasbak, Søren Hess, Paw Holdgaard, Allan Johansen, Kasper Kyhl, Bjarne Linde Norgaard, Kristian Altern Øvrehus, Niels Peter Rønnow Sand, Rolf Steffensen, Anders Thomassen, Bo Zerahn, Alfredo Perez, Giovanni Alejandro Escorza Velez, Mayra Sanchez Velez, Islam Shawky Abdel Aziz, Mahasen Abougabal, Taghreed Ahmed, Adel Allam, Ahmed Asfour, Mona Hassan, Alia Hassan, Ahmed Ibrahim, Sameh Kaffas, Ahmed Kandeel, Mohamed Mandour Ali, Ahmad Mansy, Hany Maurice, Sherif Nabil, Mahmoud Shaaban, Ana Camila Flores, Anne Poksi, Juhani Knuuti, Velipekka Kokkonen, Martti Larikka, Valtteri Uusitalo, Matthieu Bailly, Samuel Burg, Jean-François Deux, Vincent Habouzit, Fabien Hyafil, Olivier Lairez, Franck Proffit, Hamza Regaieg, Laure Sarda-Mantel, Vania Tacher, Roman P. Schneider, Harold Ayetey, George Angelidis, Aikaterini Archontaki, Sofia Chatziioannou, Ioannis Datseris, Christina Fragkaki, Panagiotis Georgoulias, Sophia Koukouraki, Maria Koutelou, Eleni Kyrozi, Evangelos Repasos, Petros Stavrou, Pipitsa Valsamaki, Carla Gonzalez, Goleat Gutierrez, Alejandro Maldonado, Klara Buga, Ildiko Garai, Pál Maurovich-Horvat, Erzsébet Schmidt, Balint Szilveszter, Edit Várady, Nilesh Banthia, Jinendra Kumar Bhagat, Rishi Bhargava, Vivek Bhat, Partha Choudhury, Vijay Sai Chowdekar, Aparna Irodi, Shashank Jain, Elizabeth Joseph, Sukriti Kumar, Prof Dr Girijanandan Mahapatra, Deepanjan Mitra, Bhagwant Rai Mittal, Ahmad Ozair, Chetan Patel, Tapan Patel, Ravi Patel, Shivani Patel, Sudhir Saxena, Shantanu Sengupta, Santosh Singh, Bhanupriya Singh, Ashwani Sood, Atul Verma, Erwin Affandi, Padma Savenadia Alam, Edison Edison, Gani Gunawan, Habusari Hapkido, Basuki Hidayat, Aulia Huda, Anggoro Praja Mukti, Djoko Prawiro, Erwin Affandi Soeriadi, Hilman Syawaluddin, Amjed Albadr, Majid Assadi, Farshad Emami, Golnaz Houshmand, Majid Maleki, Maryam Tajik Rostami, Seyed Rasoul Zakavi, Eed Abu Zaid, Svetlana Agranovich, Yoav Arnson, Rachel Bar-Shalom, Alex Frenkel, Galit Knafo, Rachel Lugassi, Israel Shlomo Maor Moalem, Maya Mor, Noam Muskal, Sara Ranser, Aryeh Shalev, Domenico Albano, Pierpaolo Alongi, Gaspare Arnone, Elisa Bagatin, Sergio Baldari, Matteo Bauckneht, Paolo Bertelli, Francesco Bianco, Rachele Bonfiglioli, Roberto Boni, Andrea Bruno, Isabella Bruno, Elena Busnardo, Elena Califaretti, Luca Camoni, Aldo Carnevale, Roberta Casoni, Armando Ugo Cavallo, Giorgio Cavenaghi, Franca Chierichetti, Marcello Chiocchi, Corrado Cittanti, Mauro Colletta, Umberto Conti, Alberto Cossu, Alberto Cuocolo, Marco Cuzzocrea, Maria Luisa De Rimini, Giuseppe De Vincentis, Eleonora Del Giudice, Alberico Del Torto, Veronica Della Tommasina, Rexhep Durmo, Paola Anna Erba, Laura Evangelista, Riccardo Faletti, Evelina Faragasso, Mohsen Farsad, Paola Ferro, Luigia Florimonte, Viviana Frantellizzi, Fabio Massimo Fringuelli, Marco Gatti, Angela Gaudiano, Alessia Gimelli, Raffaele Giubbini, Francesca Giuffrida, Salvatore Ialuna, Riccardo Laudicella, Lucia Leccisotti, Lucia Leva, Riccardo Liga, Carlo Liguori, Giampiero Longo, Margherita Maffione, Maria Elisabetta Mancini, Claudio Marcassa, Elisa Milan, Barbara Nardi, Sara Pacella, Giovanna Pepe, Gianluca Pontone, Sabina Pulizzi, Natale Quartuccio, Lucia Rampin, Fabrizio Ricci, Pierluigi Rossini, Giuseppe Rubini, Vincenzo Russo, Gian Mauro Sacchetti, Gianmario Sambuceti, Massimo Scarano, Roberto Sciagrà, Massimiliano Sperandio, Antonella Stefanelli, Guido Ventroni, Stefania Zoboli, Dainia Baugh, Duane Chambers, Ernest Madu, Felix Nunura, Hiroshi Asano, Chimura Misato Chimura, Shinichiro Fujimoto, Koichiro Fujisue, Tomohisa Fukunaga, Yoshimitsu Fukushima, Kae Fukuyama, Jun Hashimoto, Yasutaka Ichikawa, Nobuo Iguchi, Masamichi Imai, Anri Inaki, Hayato Ishimura, Satoshi Isobe, Toshiaki Kadokami, Takao Kato, Shinichiro Kumita, Hirotaka Maruno, Hiroyuki Mataki, Masao Miyagawa, Ryota Morimoto, Masao Moroi, Shigeki Nagamachi, Kenichi Nakajima, Tomoaki Nakata, Ryo Nakazato, Mamoru Nanasato, Masanao Naya, Takashi Norikane, Yasutoshi Ohta, Satoshi Okayama, Atsutaka Okizaki, Yoichi Otomi, Hideki Otsuka, Masaki Saito, Sakata Yasushi Sakata, Masayoshi Sarai, Daisuke Sato, Shinya Shiraishi, Yoshinobu Suwa, Kentaro Takanami, Kazuya Takehana, Junichi Taki, Nagara Tamaki, Yasuyo Taniguchi, Hiroki Teragawa, Nobuo Tomizawa, Kenichi Tsujita, Kyoko Umeji, Yasushi Wakabayashi, Shinichiro Yamada, Shinya Yamazaki, Tatsuya Yoneyama, Mohammad Rawashdeh, Daultai Batyrkhanov, Khalid Makhdomi, Kevin Ombati, Faridah Alkandari, Masoud Garashi, Tchoyoson Lim Coie, Sonexay Rajvong, Artem Kalinin, Marika Kalnina, Mohamad Haidar, Renata Komiagiene, Giedre Kviecinskiene, Mindaugas Mataciunas, Donatas Vajauskas, Christian Picard, Noor Khairiah A. Karim, Luise Reichmuth, Anthony Samuel, Mohammad Aaftaab Allarakha, Ambedhkar Shantaram Naojee, Erick Alexanderson-Rosas, Erika Barragan, Alejandro Becerril González-Montecinos, Manuel Cabada, Daniel Calderon Rodriguez, Isabel Carvajal-Juarez, Violeta Cortés, Filiberto Cortés, Erasmo De La Peña, Manlio Gama-Moreno, Luis González, Nelsy Gonzalez Ramírez, Moisés Jiménez-Santos, Luis Matos, Edgar Monroy, Martha Morelos, Mario Ornelas, Jose Alberto Ortga Ramirez, Andrés Preciado-Anaya, Óscar Ulises Preciado-Gutiérrez, Adriana Puente Barragan, Sandra Graciela Rosales Uvera, Sigelinda Sandoval, Miguel Santaularia Tomas, Lilia M. Sierra-Galan, Silvia Siu, Enrique Vallejo, Mario Valles, Marc Faraggi, Erdenechimeg Sereegotov, Srdja Ilic, Nozha Ben-Rais, Nadia Ismaili Alaoui, Sara Taleb, Khin Pa Pa Myo, Phyo Si Thu, Ram Kumar Ghimire, Bijoy Rajbanshi, Peter Barneveld, Andor Glaudemans, Jesse Habets, Klaas Pieter Koopmans, Jeroen Manders, Stefan Pool, Arthur Scholte, Asbjørn Scholtens, Riemer Slart, Paul Thimister, Erik-Jan Van Asperen, Niels Veltman, Derk Verschure, Nils Wagenaar, John Edmond, Chris Ellis, Kerryanne Johnson, Ross Keenan, Shaw Hua (Anthony) Kueh, Christopher Occleshaw, Alexander Sasse, Andrew To, Niels Van Pelt, Calum Young, Teresa Cuadra, Hector Bladimir Roque Vanegas, Idrissa Adamou Soli, Djibrillou Moussa Issoufou, Tolulope Ayodele, Chibuzo Madu, Yetunde Onimode, Elen Efros-Monsen, Signe Helene Forsdahl, Jenni-Mari Hildre Dimmen, Arve Jørgensen, Isabel Krohn, Pål Løvhaugen, Anders Tjellaug Bråten, Humoud Al Dhuhli, Faiza Al Kindi, Naeema Al-Bulushi, Zabah Jawa, Naima Tag, Muhammad Shehzad Afzal, Shazia Fatima, Muhammad Numair Younis, Musab Riaz, Mohammad Saadullah, Yariela Herrera, Dora Lenturut-Katal, Manuel Castillo Vázquez, José Ortellado, Afroza Akhter, Dianbo Cao, Stephen Cheung, Xu Dai, Lianggeng Gong, Dan Han, Yang Hou, Caiying Li, Tao Li, Dong Li, Sijin Li, Jinkang Liu, Hui Liu, Ming Yen Ng, Kai Sun, Gongshun Tang, Jian Wang, Ximing Wang, Zhao-Qian Wang, Yining Wang, Yifan Wang, Jiang Wu, Zhifang Wu, Liming Xia, Jiangxi Xiao, Lei Xu, Youyou Yang, Wu Yin, Jianqun Yu, Li Yuan, Tong Zhang, Longjiang Zhang, Yong-Gao Zhang, Xiaoli Zhang, Li Zhu, Ana Alfaro, Paz Abrihan, Asela Barroso, Eric Cruz, Marie Rhiamar Gomez, Vincent Peter Magboo, John Michael Medina, Jerry Obaldo, Davidson Pastrana, Christian Michael Pawhay, Alvin Quinon, Jeanelle Margareth Tang, Bettina Tecson, Kristine Joy Uson, Mila Uy, Magdalena Kostkiewicz, Jolanta Kunikowska, Nuno Bettencourt, Guilhermina Cantinho, Antonio Ferreira, Ghulam Syed, Samer Arnous, Said Atyani, Angela Byrne, Tadhg Gleeson, David Kerins, Conor Meehan, David Murphy, Mark Murphy, John Murray, Julie O'Brien, Ji-In Bang, Henry Bom, Sang-Geon Cho, Chae Moon Hong, Su Jin Jang, Yong Hyu Jeong, Won Jun Kang, Ji-Young Kim, Jaetae Lee, Chang Kyeong Namgung, Young So, Kyoung Sook Won, Venjamin Majstorov, Marija Vavlukis, Barbara Gužic Salobir, Monika Štalc, Theodora Benedek, Imre Benedek, Raluca Mititelu, Claudiu Adrian Stan, Alexey Ansheles, Olga Dariy, Olga Drozdova, Nina Gagarina, Vsevolod Milyevich Gulyaev, Irina Itskovich, Anatoly Karalkin, Alexander Kokov, Ekaterina Migunova, Viktor Pospelov, Daria Ryzhkova, Guzaliya Saifullina, Svetlana Sazonova, Vladimir Sergienko, Irina Shurupova, Tatjana Trifonova, Wladimir Yurievich Ussov, Margarita Vakhromeeva, Nailya Valiullina, Konstantin Zavadovsky, Kirill Zhuravlev, Subhani Okarvi, Dragana Sobic Saranovic, Felix Keng, Jia Hao Jason See, Ramkumar Sekar, Min Sen Yew, Andrej Vondrak, Shereen Bejai, George Bennie, Ria Bester, Gerrit Engelbrecht, Osayande Evbuomwan, Harlem Gongxeka, Magritha Jv Vuuren, Mitchell Kaplan, Purbhoo Khushica, Hoosen Lakhi, Lizette Louw, Nico Malan, Katarina Milos, Moshe Modiselle, Stuart More, Mathava Naidoo, Leonie Scholtz, Mboyo Vangu, Santiago Aguadé-Bruix, Isabel Blanco, Antonio Cabrera, Alicia Camarero, Irene Casáns-Tormo, Hug Cuellar-Calabria, Albert Flotats, Maria Eugenia Fuentes Cañamero, María Elia García, Amelia Jimenez-Heffernan, Rubén Leta, Javier Lopez Diaz, Luis Lumbreras, Juan Javier Marquez-Cabeza, Francisco Martin, Anxo Martinez de Alegria, Francisco Medina, Maria Pedrera Canal, Virginia Peiro, Virginia Pubul-Nuñez, Juan Ignacio Rayo Madrid, Cristina Rodríguez Rey, Ricardo Ruano Perez, Joaquín Ruiz, Gertrudis Sabatel Hernández, Ana Sevilla, Nahla Zeidán, Damayanthi Nanayakkara, Chandraguptha Udugama, Magnus Simonsson, Hatem Alkadhi, Ronny Ralf Buechel, Peter Burger, Luca Ceriani, Bart De Boeck, Christoph Gräni, Alix Juillet de Saint Lager Lucas, Christel H. Kamani, Nadine Kawel-Boehm, Robert Manka, John O. Prior, Axel Rominger, Jean-Paul Vallée, Benjapa Khiewvan, Teerapon Premprabha, Tanyaluck Thientunyakit, Ali Sellem, Kemal Metin Kir, Haluk Sayman, Mugisha Julius Sebikali, Zerida Muyinda, Yaroslav Kmetyuk, Pavlo Korol, Olena Mykhalchenko, Volodymyr Pliatsek, Maryna Satyr, Batool Albalooshi, Mohamed Ismail Ahmed Hassan, Jill Anderson, Punit Bedi, Thomas Biggans, Anda Bularga, Russell Bull, Rajesh Burgul, John-Paul Carpenter, Duncan Coles, David Cusack, Aparna Deshpande, John Dougan, Timothy Fairbairn, Alexia Farrugia, Deepa Gopalan, Alistair Gummow, Prasad Guntur Ramkumar, Mark Hamilton, Mark Harbinson, Thomas Hartley, Benjamin Hudson, Nikhil Joshi, Michael Kay, Andrew Kelion, Azhar Khokhar, Jamie Kitt, Ken Lee, Chen Low, Sze Mun Mak, Ntouskou Marousa, Jon Martin, Elisa Mcalindon, Leon Menezes, Gareth Morgan-Hughes, Alastair Moss, Anthony Murray, Edward Nicol, Dilip Patel, Charles Peebles, Francesca Pugliese, Jonathan Carl Luis Rodrigues, Christopher Rofe, Nikant Sabharwal, Rebecca Schofield, Thomas Semple, Naveen Sharma, Peter Strouhal, Deepak Subedi, William Topping, Katharine Tweed, Jonathan Weir-Mccall, Suhny Abbara, Taimur Abbasi, Brian Abbott, Shady Abohashem, Sandra Abramson, Tarek Al-Abboud, Mouaz Al-Mallah, Omar Almousalli, Karthikeyan Ananthasubramaniam, Mohan Ashok Kumar, Jeffrey Askew, Lea Attanasio, Mallory Balmer-Swain, Richard R. Bayer, Adam Bernheim, Sabha Bhatti, Erik Bieging, Ron Blankstein, Stephen Bloom, Sean Blue, David Bluemke, Andressa Borges, Kelley Branch, Paco Bravo, Jessica Brothers, Matthew Budoff, Renée Bullock-Palmer, Angela Burandt, Floyd W. Burke, Kelvin Bush, Candace Candela, Elizabeth Capasso, Joao Cavalcante, Donald Chang, Saurav Chatterjee, Yiannis Chatzizisis, Michael Cheezum, Tiffany Chen, Jennifer Chen, Marcus Chen, James Clarcq, Ayreen Cordero, Matthew Crim, Sorin Danciu, Bruce Decter, Nimish Dhruva, Neil Doherty, Rami Doukky, Anjori Dunbar, William Duvall, Rachael Edwards, Kerry Esquitin, Husam Farah, Emilio Fentanes, Maros Ferencik, Daniel Fisher, Daniel Fitzpatrick, Cameron Foster, Tony Fuisz, Michael Gannon, Lori Gastner, Myron Gerson, Brian Ghoshhajra, Alan Goldberg, Brian Goldner, Jorge Gonzalez, Rosco Gore, Sandra Gracia-López, Fadi Hage, Agha Haider, Sofia Haider, Yasmin Hamirani, Karen Hassen, Mallory Hatfield, Carolyn Hawkins, Katie Hawthorne, Nicholas Heath, Robert Hendel, Phillip Hernandez, Gregory Hill, Stephen Horgan, Jeff Huffman, Lynne Hurwitz, Ami Iskandrian, Rajesh Janardhanan, Christine Jellis, Scott Jerome, Dinesh Kalra, Summanther Kaviratne, Fernando Kay, Faith Kelly, Omar Khalique, Mona Kinkhabwala, George Kinzfogl Iii, Jacqueline Kircher, Rachael Kirkbride, Michael Kontos, Anupama Kottam, Joseph Krepp, Jay Layer, Steven H. Lee, Jeffrey Leppo, John Lesser, Steve Leung, Howard Lewin, Diana Litmanovich, Yiyan Liu, Kathleen Magurany, Jeremy Markowitz, Amanda Marn, Stephen E. Matis, Michael Mckenna, Tony Mcrae, Fernando Mendoza, Michael Merhige, David Min, Chanan Moffitt, Karen Moncher, Warren Moore, Shamil Morayati, Michael Morris, Mahmud Mossa-Basha, Zorana Mrsic, Venkatesh Murthy, Prashant Nagpal, Kyle Napier, Katarina Nelson, Prabhjot Nijjar, Medhat Osman, Edward Passen, Amit Patel, Pravin Patil, Ryan Paul, Lawrence Phillips, Venkateshwar Polsani, Rajaram Poludasu, Brian Pomerantz, Thomas Porter, Ryan Prentice, Amit Pursnani, Mark Rabbat, Suresh Ramamurti, Florence Rich, Hiram Rivera Luna, Austin Robinson, Kim Robles, Cesar Rodríguez, Mark Rorie, John Rumberger, Raymond Russell, Philip Sabra, Diego Sadler, Mary Schemmer, U. Joseph Schoepf, Samir Shah, Nishant Shah, Sujata Shanbhag, Gaurav Sharma, Steven Shayani, Jamshid Shirani, Pushpa Shivaram, Steven Sigman, Mitch Simon, Ahmad Slim, David Smith, Alexandra Smith, Prem Soman, Aditya Sood, Monvadi Barbara Srichai-Parsia, James Streeter, Albert T, Ahmed Tawakol, Dustin Thomas, Randall Thompson, Tara Torbet, Desiree Trinidad, Shawn Ullery, Samuel Unzek, Seth Uretsky, Srikanth Vallurupalli, Vikas Verma, Alfonso Waller, Ellen Wang, Parker Ward, Gaby Weissman, George Wesbey, Kelly White, David Winchester, David Wolinsky, Sandra Yost, Michael Zgaljardic, Omar Alonso, Mario Beretta, Rodolfo Ferrando, Miguel Kapitan, Fernando Mut, Omoa Djuraev, Gulnora Rozikhodjaeva, Ha Le Ngoc, Son Hong Mai, Xuan Canh Nguyen, Kudo, T, Lahey, R, Hirschfeld, C, Williams, M, Lu, B, Alasnag, M, Bhatia, M, Henry Bom, H, Dautov, T, Fazel, R, Karthikeyan, G, Keng, F, Rubinshtein, R, Better, N, Cerci, R, Dorbala, S, Raggi, P, Shaw, L, Villines, T, Vitola, J, Choi, A, Malkovskiy, E, Goebel, B, Cohen, Y, Randazzo, M, Pascual, T, Pynda, Y, Dondi, M, Paez, D, Einstein, A, Hinterleitner, G, Lu, Y, Morozova, O, Xu, Z, Lopez-Mattei, J, Parwani, P, Nasery, M, Goda, A, Shirka, E, Benlabgaa, R, Bouyoucef, S, Medjahedi, A, Nailli, Q, Agolti, M, Aguero, R, Alak, M, Alberguina, L, Arroñada, G, Astesiano, A, Norton, C, Benteo, P, Blanco, J, Bonelli, J, Bustos, J, Cabrejas, R, Cachero, J, Campisi, R, Canderoli, A, Carames, S, Carrascosa, P, Castro, R, Cendoya, O, Cognigni, L, Collaud, C, Cortes, C, Courtis, J, Cragnolino, D, Daicz, M, De La Vega, A, De Maria, S, Del Riego, H, Dettori, F, Deviggiano, A, Dragonetti, L, Embon, M, Enriquez, R, Ensinas, J, Faccio, F, Facello, A, Garofalo, D, Geronazzo, R, Gonza, N, Gutierrez, L, Guzzo, M, Hasbani, V, Huerin, M, Jäger, V, Lewkowicz, J, López De Munaín, M, Lotti, J, Marquez, A, Masoli, O, Mastrovito, E, Mayoraz, M, Melado, G, Mele, A, Merani, M, Meretta, A, Molteni, S, Montecinos, M, Noguera, E, Novoa, C, Sueldo, C, Ascani, S, Pollono, P, Pujol, M, Radzinschi, A, Raimondi, G, Redruello, M, Rodríguez, M, Romero, R, Acuña, A, Rovaletti, F, San Miguel, L, Solari, L, Strada, B, Traverso, S, Traverzo, S, Espeche, M, Weihmuller, J, Wolcan, J, Zeffiro, S, Sakanyan, M, Beuzeville, S, Boktor, R, Butler, P, Calcott, J, Carr, L, Chan, V, Chao, C, Chong, W, Dobson, M, Downie, D, Dwivedi, G, Elison, B, Engela, J, Francis, R, Gaikwad, A, Basavaraj, A, Goodwin, B, Greenough, R, Hamilton-Craig, C, Hsieh, V, Joshi, S, Lederer, K, Lee, K, Lee, J, Magnussen, J, Mai, N, Mander, G, Murton, F, Nandurkar, D, Neill, J, O'Rourke, E, O'Sullivan, P, Pandos, G, Pathmaraj, K, Pitman, A, Poulter, R, Premaratne, M, Prior, D, Ridley, L, Rutherford, N, Salehi, H, Saunders, C, Scarlett, L, Seneviratne, S, Shetty, D, Shrestha, G, Shulman, J, Solanki, V, Stanton, T, Stuart, M, Stubbs, M, Swainson, I, Taubman, K, Taylor, A, Thomas, P, Unger, S, Upton, A, Vamadevan, S, Van Gaal, W, Verjans, J, Voutnis, D, Wayne, V, Wilson, P, Wong, D, Wong, K, Younger, J, Feuchtner, G, Mirzaei, S, Weiss, K, Maroz-Vadalazhskaya, N, Gheysens, O, Homans, F, Moreno-Reyes, R, Pasquet, A, Roelants, V, Van De Heyning, C, Ríos, R, Soldat-Stankovic, V, Stankovic, S, Albernaz Siqueira, M, Almeida, A, Alves Togni, P, Andrade, J, Andrade, L, Anselmi, C, Araújo, R, Azevedo, G, Bezerra, S, Biancardi, R, Grossman, G, Brandão, S, Pianta, D, Carreira, L, Castro, B, Chang, T, Cunali, F, Cury, R, Dantas, R, de Amorim Fernandes, F, De Lorenzo, A, De Macedo Filho, R, Erthal, F, Fernandes, F, Fernandes, J, De Souza, T, Alves, W, Ghini, B, Goncalves, L, Gottlieb, I, Hadlich, M, Kameoka, V, Lima, R, Lima, A, Lopes, R, Machado e Silva, R, Magalhães, T, Silva, F, Mastrocola, L, Medeiros, F, Meneghetti, J, Naue, V, Naves, D, Nolasco, R, Nomura, C, Oliveira, J, Paixao, E, De Carvalho, F, Pinto, I, Possetti, P, Quinta, M, Nogueira Ramos, R, Rocha, R, Rodrigues, A, Rodrigues, C, Romantini, L, Sanches, A, Santana, S, Sara da Silva, L, Schvartzman, P, Matushita, C, Senra, T, Shiozaki, A, Menezes de Siqueira, M, Siqueira, C, Smanio, P, Soares, C, Junior, J, Bittencourt, M, Spiro, B, Mesquita, C, Torreao, J, Torres, R, Uellendahl, M, Monte, G, Veríssimo, O, Cabeda, E, Pedras, F, Waltrick, R, Zapparoli, M, Naseer, H, Garcheva-Tsacheva, M, Kostadinova, I, Theng, Y, Abikhzer, G, Barette, R, Chow, B, Dabreo, D, Friedrich, M, Garg, R, Hafez, M, Johnson, C, Kiess, M, Leipsic, J, Leung, E, Miller, R, Oikonomou, A, Probst, S, Roifman, I, Small, G, Tandon, V, Trivedi, A, White, J, Zukotynski, K, Canessa, J, Muñoz, G, Concha, C, Hidalgo, P, Lovera, C, Massardo, T, Vargas, L, Abad, P, Arturo, H, Ayala, S, Benitez, L, Cadena, A, Caicedo, C, Moncayo, A, Gomez, S, Gutierrez Villamil, C, Jaimes, C, Londoño, J, Londoño Blair, J, Pabon, L, Pineda, M, Rojas, J, Ruiz, D, Escobar, M, Vasquez, A, Vergel, D, Zuluaga, A, Gamboa, I, Castro, G, González, U, Baric, A, Batinic, T, Franceschi, M, Paar, M, Jukic, M, Medakovic, P, Persic, V, Prpic, M, Punda, A, Batista, J, Gómez Lauchy, J, Gutierrez, Y, Menéndez, R, Peix, A, Rochela, L, Panagidis, C, Petrou, I, Engelmann, V, Kaminek, M, Kincl, V, Lang, O, Simanek, M, Abdulla, J, Bøttcher, M, Christensen, M, Gormsen, L, Hasbak, P, Hess, S, Holdgaard, P, Johansen, A, Kyhl, K, Norgaard, B, Øvrehus, K, Rønnow Sand, N, Steffensen, R, Thomassen, A, Zerahn, B, Perez, A, Escorza Velez, G, Velez, M, Abdel Aziz, I, Abougabal, M, Ahmed, T, Allam, A, Asfour, A, Hassan, M, Hassan, A, Ibrahim, A, Kaffas, S, Kandeel, A, Ali, M, Mansy, A, Maurice, H, Nabil, S, Shaaban, M, Flores, A, Poksi, A, Knuuti, J, Kokkonen, V, Larikka, M, Uusitalo, V, Bailly, M, Burg, S, Deux, J, Habouzit, V, Hyafil, F, Lairez, O, Proffit, F, Regaieg, H, Sarda-Mantel, L, Tacher, V, Schneider, R, Ayetey, H, Angelidis, G, Archontaki, A, Chatziioannou, S, Datseris, I, Fragkaki, C, Georgoulias, P, Koukouraki, S, Koutelou, M, Kyrozi, E, Repasos, E, Stavrou, P, Valsamaki, P, Gonzalez, C, Gutierrez, G, Maldonado, A, Buga, K, Garai, I, Maurovich-Horvat, P, Schmidt, E, Szilveszter, B, Várady, E, Banthia, N, Bhagat, J, Bhargava, R, Bhat, V, Choudhury, P, Chowdekar, V, Irodi, A, Jain, S, Joseph, E, Kumar, S, Girijanandan Mahapatra, P, Mitra, D, Mittal, B, Ozair, A, Patel, C, Patel, T, Patel, R, Patel, S, Saxena, S, Sengupta, S, Singh, S, Singh, B, Sood, A, Verma, A, Affandi, E, Alam, P, Edison, E, Gunawan, G, Hapkido, H, Hidayat, B, Huda, A, Mukti, A, Prawiro, D, Soeriadi, E, Syawaluddin, H, Albadr, A, Assadi, M, Emami, F, Houshmand, G, Maleki, M, Rostami, M, Zakavi, S, Zaid, E, Agranovich, S, Arnson, Y, Bar-Shalom, R, Frenkel, A, Knafo, G, Lugassi, R, Maor Moalem, I, Mor, M, Muskal, N, Ranser, S, Shalev, A, Albano, D, Alongi, P, Arnone, G, Bagatin, E, Baldari, S, Bauckneht, M, Bertelli, P, Bianco, F, Bonfiglioli, R, Boni, R, Bruno, A, Bruno, I, Busnardo, E, Califaretti, E, Camoni, L, Carnevale, A, Casoni, R, Cavallo, A, Cavenaghi, G, Chierichetti, F, Chiocchi, M, Cittanti, C, Colletta, M, Conti, U, Cossu, A, Cuocolo, A, Cuzzocrea, M, De Rimini, M, De Vincentis, G, Del Giudice, E, Del Torto, A, Della Tommasina, V, Durmo, R, Erba, P, Evangelista, L, Faletti, R, Faragasso, E, Farsad, M, Ferro, P, Florimonte, L, Frantellizzi, V, Fringuelli, F, Gatti, M, Gaudiano, A, Gimelli, A, Giubbini, R, Giuffrida, F, Ialuna, S, Laudicella, R, Leccisotti, L, Leva, L, Liga, R, Liguori, C, Longo, G, Maffione, M, Mancini, M, Marcassa, C, Milan, E, Nardi, B, Pacella, S, Pepe, G, Pontone, G, Pulizzi, S, Quartuccio, N, Rampin, L, Ricci, F, Rossini, P, Rubini, G, Russo, V, Sacchetti, G, Sambuceti, G, Scarano, M, Sciagrà, R, Sperandio, M, Stefanelli, A, Ventroni, G, Zoboli, S, Baugh, D, Chambers, D, Madu, E, Nunura, F, Asano, H, Chimura, C, Fujimoto, S, Fujisue, K, Fukunaga, T, Fukushima, Y, Fukuyama, K, Hashimoto, J, Ichikawa, Y, Iguchi, N, Imai, M, Inaki, A, Ishimura, H, Isobe, S, Kadokami, T, Kato, T, Kumita, S, Maruno, H, Mataki, H, Miyagawa, M, Morimoto, R, Moroi, M, Nagamachi, S, Nakajima, K, Nakata, T, Nakazato, R, Nanasato, M, Naya, M, Norikane, T, Ohta, Y, Okayama, S, Okizaki, A, Otomi, Y, Otsuka, H, Saito, M, Sakata, S, Sarai, M, Sato, D, Shiraishi, S, Suwa, Y, Takanami, K, Takehana, K, Taki, J, Tamaki, N, Taniguchi, Y, Teragawa, H, Tomizawa, N, Tsujita, K, Umeji, K, Wakabayashi, Y, Yamada, S, Yamazaki, S, Yoneyama, T, Rawashdeh, M, Batyrkhanov, D, Makhdomi, K, Ombati, K, Alkandari, F, Garashi, M, Coie, T, Rajvong, S, Kalinin, A, Kalnina, M, Haidar, M, Komiagiene, R, Kviecinskiene, G, Mataciunas, M, Vajauskas, D, Picard, C, Karim, N, Reichmuth, L, Samuel, A, Allarakha, M, Naojee, A, Alexanderson-Rosas, E, Barragan, E, González-Montecinos, A, Cabada, M, Rodriguez, D, Carvajal-Juarez, I, Cortés, V, Cortés, F, De La Peña, E, Gama-Moreno, M, González, L, Ramírez, N, Jiménez-Santos, M, Matos, L, Monroy, E, Morelos, M, Ornelas, M, Ortga Ramirez, J, Preciado-Anaya, A, Preciado-Gutiérrez, Ó, Barragan, A, Rosales Uvera, S, Sandoval, S, Tomas, M, Sierra-Galan, L, Siu, S, Vallejo, E, Valles, M, Faraggi, M, Sereegotov, E, Ilic, S, Ben-Rais, N, Alaoui, N, Taleb, S, Pa Myo, K, Thu, P, Ghimire, R, Rajbanshi, B, Barneveld, P, Glaudemans, A, Habets, J, Koopmans, K, Manders, J, Pool, S, Scholte, A, Scholtens, A, Slart, R, Thimister, P, Van Asperen, E, Veltman, N, Verschure, D, Wagenaar, N, Edmond, J, Ellis, C, Johnson, K, Keenan, R, Kueh, S, Occleshaw, C, Sasse, A, To, A, Van Pelt, N, Young, C, Cuadra, T, Roque Vanegas, H, Soli, I, Issoufou, D, Ayodele, T, Madu, C, Onimode, Y, Efros-Monsen, E, Forsdahl, S, Hildre Dimmen, J, Jørgensen, A, Krohn, I, Løvhaugen, P, Bråten, A, Al Dhuhli, H, Al Kindi, F, Al-Bulushi, N, Jawa, Z, Tag, N, Afzal, M, Fatima, S, Younis, M, Riaz, M, Saadullah, M, Herrera, Y, Lenturut-Katal, D, Vázquez, M, Ortellado, J, Akhter, A, Cao, D, Cheung, S, Dai, X, Gong, L, Han, D, Hou, Y, Li, C, Li, T, Li, D, Li, S, Liu, J, Liu, H, Ng, M, Sun, K, Tang, G, Wang, J, Wang, X, Wang, Z, Wang, Y, Wu, J, Wu, Z, Xia, L, Xiao, J, Xu, L, Yang, Y, Yin, W, Yu, J, Yuan, L, Zhang, T, Zhang, L, Zhang, Y, Zhang, X, Zhu, L, Alfaro, A, Abrihan, P, Barroso, A, Cruz, E, Gomez, M, Magboo, V, Medina, J, Obaldo, J, Pastrana, D, Pawhay, C, Quinon, A, Tang, J, Tecson, B, Uson, K, Uy, M, Kostkiewicz, M, Kunikowska, J, Bettencourt, N, Cantinho, G, Ferreira, A, Syed, G, Arnous, S, Atyani, S, Byrne, A, Gleeson, T, Kerins, D, Meehan, C, Murphy, D, Murphy, M, Murray, J, O'Brien, J, Bang, J, Bom, H, Cho, S, Hong, C, Jang, S, Jeong, Y, Kang, W, Kim, J, Namgung, C, So, Y, Won, K, Majstorov, V, Vavlukis, M, Salobir, B, Štalc, M, Benedek, T, Benedek, I, Mititelu, R, Stan, C, Ansheles, A, Dariy, O, Drozdova, O, Gagarina, N, Gulyaev, V, Itskovich, I, Karalkin, A, Kokov, A, Migunova, E, Pospelov, V, Ryzhkova, D, Saifullina, G, Sazonova, S, Sergienko, V, Shurupova, I, Trifonova, T, Ussov, W, Vakhromeeva, M, Valiullina, N, Zavadovsky, K, Zhuravlev, K, Okarvi, S, Saranovic, D, Jason See, J, Sekar, R, Yew, M, Vondrak, A, Bejai, S, Bennie, G, Bester, R, Engelbrecht, G, Evbuomwan, O, Gongxeka, H, Vuuren, M, Kaplan, M, Khushica, P, Lakhi, H, Louw, L, Malan, N, Milos, K, Modiselle, M, More, S, Naidoo, M, Scholtz, L, Vangu, M, Aguadé-Bruix, S, Blanco, I, Cabrera, A, Camarero, A, Casáns-Tormo, I, Cuellar-Calabria, H, Flotats, A, Fuentes Cañamero, M, García, M, Jimenez-Heffernan, A, Leta, R, Diaz, J, Lumbreras, L, Marquez-Cabeza, J, Martin, F, Martinez de Alegria, A, Medina, F, Canal, M, Peiro, V, Pubul-Nuñez, V, Rayo Madrid, J, Rey, C, Perez, R, Ruiz, J, Hernández, G, Sevilla, A, Zeidán, N, Nanayakkara, D, Udugama, C, Simonsson, M, Alkadhi, H, Buechel, R, Burger, P, Ceriani, L, De Boeck, B, Gräni, C, Juillet de Saint Lager Lucas, A, Kamani, C, Kawel-Boehm, N, Manka, R, Prior, J, Rominger, A, Vallée, J, Khiewvan, B, Premprabha, T, Thientunyakit, T, Sellem, A, Kir, K, Sayman, H, Sebikali, M, Muyinda, Z, Kmetyuk, Y, Korol, P, Mykhalchenko, O, Pliatsek, V, Satyr, M, Albalooshi, B, Ahmed Hassan, M, Anderson, J, Bedi, P, Biggans, T, Bularga, A, Bull, R, Burgul, R, Carpenter, J, Coles, D, Cusack, D, Deshpande, A, Dougan, J, Fairbairn, T, Farrugia, A, Gopalan, D, Gummow, A, Ramkumar, P, Hamilton, M, Harbinson, M, Hartley, T, Hudson, B, Joshi, N, Kay, M, Kelion, A, Khokhar, A, Kitt, J, Low, C, Mak, S, Marousa, N, Martin, J, Mcalindon, E, Menezes, L, Morgan-Hughes, G, Moss, A, Murray, A, Nicol, E, Patel, D, Peebles, C, Pugliese, F, Luis Rodrigues, J, Rofe, C, Sabharwal, N, Schofield, R, Semple, T, Sharma, N, Strouhal, P, Subedi, D, Topping, W, Tweed, K, Weir-Mccall, J, Abbara, S, Abbasi, T, Abbott, B, Abohashem, S, Abramson, S, Al-Abboud, T, Al-Mallah, M, Almousalli, O, Ananthasubramaniam, K, Kumar, M, Askew, J, Attanasio, L, Balmer-Swain, M, Bayer, R, Bernheim, A, Bhatti, S, Bieging, E, Blankstein, R, Bloom, S, Blue, S, Bluemke, D, Borges, A, Branch, K, Bravo, P, Brothers, J, Budoff, M, Bullock-Palmer, R, Burandt, A, Burke, F, Bush, K, Candela, C, Capasso, E, Cavalcante, J, Chang, D, Chatterjee, S, Chatzizisis, Y, Cheezum, M, Chen, T, Chen, J, Chen, M, Clarcq, J, Cordero, A, Crim, M, Danciu, S, Decter, B, Dhruva, N, Doherty, N, Doukky, R, Dunbar, A, Duvall, W, Edwards, R, Esquitin, K, Farah, H, Fentanes, E, Ferencik, M, Fisher, D, Fitzpatrick, D, Foster, C, Fuisz, T, Gannon, M, Gastner, L, Gerson, M, Ghoshhajra, B, Goldberg, A, Goldner, B, Gonzalez, J, Gore, R, Gracia-López, S, Hage, F, Haider, A, Haider, S, Hamirani, Y, Hassen, K, Hatfield, M, Hawkins, C, Hawthorne, K, Heath, N, Hendel, R, Hernandez, P, Hill, G, Horgan, S, Huffman, J, Hurwitz, L, Iskandrian, A, Janardhanan, R, Jellis, C, Jerome, S, Kalra, D, Kaviratne, S, Kay, F, Kelly, F, Khalique, O, Kinkhabwala, M, Iii, G, Kircher, J, Kirkbride, R, Kontos, M, Kottam, A, Krepp, J, Layer, J, Lee, S, Leppo, J, Lesser, J, Leung, S, Lewin, H, Litmanovich, D, Liu, Y, Magurany, K, Markowitz, J, Marn, A, Matis, S, Mckenna, M, Mcrae, T, Mendoza, F, Merhige, M, Min, D, Moffitt, C, Moncher, K, Moore, W, Morayati, S, Morris, M, Mossa-Basha, M, Mrsic, Z, Murthy, V, Nagpal, P, Napier, K, Nelson, K, Nijjar, P, Osman, M, Passen, E, Patel, A, Patil, P, Paul, R, Phillips, L, Polsani, V, Poludasu, R, Pomerantz, B, Porter, T, Prentice, R, Pursnani, A, Rabbat, M, Ramamurti, S, Rich, F, Luna, H, Robinson, A, Robles, K, Rodríguez, C, Rorie, M, Rumberger, J, Russell, R, Sabra, P, Sadler, D, Schemmer, M, Schoepf, U, Shah, S, Shah, N, Shanbhag, S, Sharma, G, Shayani, S, Shirani, J, Shivaram, P, Sigman, S, Simon, M, Slim, A, Smith, D, Smith, A, Soman, P, Srichai-Parsia, M, Streeter, J, T, A, Tawakol, A, Thomas, D, Thompson, R, Torbet, T, Trinidad, D, Ullery, S, Unzek, S, Uretsky, S, Vallurupalli, S, Verma, V, Waller, A, Wang, E, Ward, P, Weissman, G, Wesbey, G, White, K, Winchester, D, Wolinsky, D, Yost, S, Zgaljardic, M, Alonso, O, Beretta, M, Ferrando, R, Kapitan, M, Mut, F, Djuraev, O, Rozikhodjaeva, G, Le Ngoc, H, Mai, S, and Nguyen, X

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Heart disease, business.industry, cardiac testing, coronavirus, COVID-19, global health, Disease, medicine.disease_cause, medicine.disease, coronaviru, cardiovascular disease, RC666-701, Emergency medicine, Pandemic, medicine, Global health, Diseases of the circulatory (Cardiovascular) system, business, Coronavirus
Abstract

Background: The coronavirus disease-2019 (COVID-19) pandemic significantly affected management of cardiovascular disease around the world. The effect of the pandemic on volume of cardiovascular diagnostic procedures is not known. Objectives: This study sought to evaluate the effects of the early phase of the COVID-19 pandemic on cardiovascular diagnostic procedures and safety practices in Asia. Methods: The International Atomic Energy Agency conducted a worldwide survey to assess changes in cardiovascular procedure volume and safety practices caused by COVID-19. Testing volumes were reported for March 2020 and April 2020 and were compared to those from March 2019. Data from 180 centers across 33 Asian countries were grouped into 4 subregions for comparison. Results: Procedure volumes decreased by 47% from March 2019 to March 2020, showing recovery from March 2020 to April 2020 in Eastern Asia, particularly in China. The majority of centers cancelled outpatient activities and increased time per study. Practice changes included implementing physical distancing and restricting visitors. Although COVID testing was not commonly performed, it was conducted in one-third of facilities in Eastern Asia. The most severe reductions in procedure volumes were observed in lower-income countries, where volumes decreased 81% from March 2019 to April 2020. Conclusions: The COVID-19 pandemic in Asia caused significant reductions in cardiovascular diagnostic procedures, particularly in low-income countries. Further studies on effects of COVID-19 on cardiovascular outcomes and changes in care delivery are warranted.

Published
2021

138. Photocatalytic properties of titanium dioxide sputtered on a nanostructured substrate

Author

Turkevych, I., Pihosh, Y., Goto, M., Kasahara, A., Tosa, M., Kato, S., Takehana, K., Takamasu, T., Kido, G., and Koguchi, N.

Subjects
*TITANIUM dioxide, *ALUMINUM oxide, *PHOTOCATALYSIS, *FULLERENES
Abstract

Abstract: The effective one-step physical approach is demonstrated for the fabrication of anatase titanium dioxide nanotubes through r.f. magnetron sputtering of TiO2 on a highly ordered nanoporous anodic alumina template. The nanostructured TiO2 benefited from the combination of unique properties of both the sputtering technique that provided well-controlled environment for the fabrication of anatase phase TiO2 and the porous anodic alumina (PAA) that provided uniform and ordered nanopores. The photocatalytic properties of TiO2 films were characterized following the degradation of methylene blue molecules under UV light irradiation. The photocatalytic activity of the nanostructured TiO2 films has been found to be approximately twice higher in comparison with the flat TiO2 films fabricated at the same conditions. [Copyright &y& Elsevier]

Published
2008
Full Text
View/download PDF

139. Early identification of impaired myocardial reperfusion with serial assessment of ST segments after percutaneous transluminal coronary angioplasty during acute myocardial infarction.

Author

Watanabe, Junko, Nakamura, Seishi, Sugiura, Tetsuro, Takehana, Kazuya, Hamada, Shinichi, Miyoshi, Hironori, Saito, Daiki, Hatada, Kengo, Kurihara, Hirohiko, Baden, Masato, Iwasaka, Toshiji, Watanabe, J, Nakamura, S, Sugiura, T, Takehana, K, Hamada, S, Miyoshi, H, Saito, D, Hatada, K, and Kurihara, H

Subjects
*MYOCARDIAL infarction, *MYOCARDIAL reperfusion
Abstract

To evaluate the relation between ST-segment analysis and microvascular reperfusion in patients with acute myocardial infarction (AMI), we studied 51 patients with first AMI who were successfully treated by percutaneous transluminal coronary angioplasty (PTCA). The lead showing the greatest ST-segment elevation on the 12-lead electrocardiogram (ECG) was serially investigated until 24 hours after PTCA. Successful reperfusion was determined by technetium-99m tetrofosmin single-photon emission computed tomography. Impaired reperfusion (group 1: < 4 change in the sum of the defect score from before to immediately after PTCA) was observed in 24 patients, and successful reperfusion (group 2) was observed in 27 patients. Although ST-segment elevation was reduced significantly at 30 minutes after PTCA in group 2 (2.2 +/- 1.4 to 1.7 +/- 1.3 mm, p = 0.01), there was no significant change in group 1 (1.9 +/- 1.9 to 2.4 +/- 1.7 mm). Ten of 14 patients (71%) with persistent ST-segment elevation (DeltaST > 0 mm change in ST segment from before to 30 minutes after PTCA > 0) were in group 1, whereas 23 of 37 patients (62%) with ST-segment resolution (DeltaST < or = 0) were in group 2. The sensitivity and specificity of persistent ST-segment elevation for predicting impaired microvascular reperfusion were 42% and 85%, respectively. Thus, persistent ST-segment elevation 30 minutes after primary PTCA was a highly specific electrocardiographic marker of impaired reperfusion in patients with AMI. [ABSTRACT FROM AUTHOR]

Published
2001
Full Text
View/download PDF

140. Pericardial effusion after primary percutaneous transluminal coronary angioplasty in first Q-wave acute myocardial infarction.

Author

Sugiura, Tetsuro, Takehana, Kazuya, Sugiura, T, Takehana, K, Hatada, K, Takahashi, N, Yuasa, F, and Iwasaka, T

Subjects
*TRANSLUMINAL angioplasty, *MYOCARDIAL infarction
Abstract

To evaluate the incidence and clinical significance of infarction-associated pericardial effusion in patients with successful primary percutaneous transluminal coronary angioplasty, we studied 214 consecutive patients with a first Q-wave acute myocardial infarction. Based on 9 clinical variables, multivariate analysis was performed to determine the important variables related to the occurrence of pericardial effusion. Pericardial effusion was detected by echocardiography in 45 patients (21%); pericardial rub (p <0.001), number of advanced asynergic segments (p <0.001), ventricular aneurysmal motion (p = 0.03), and pulmonary capillary wedge pressure (p = 0.04) were found to be the important variables related to pericardial effusion. Among 45 patients with pericardial effusion, 29 patients with no pericardial rub had significantly higher pulmonary capillary wedge pressure than those with pericardial rub, whereas 16 patients with pericardial rub had a higher incidence of angiographic no reflow and ventricular aneurysmal motion than those without pericardial rub. Patients with pericardial effusion and a pericardial rub had a higher mortality rate than those without pericardial effusion (19% vs 3%; p = 0.02). Thus, pericardial effusion is still a relatively common clinical finding after primary percutaneous transluminal coronary angioplasty, and those with pericardial effusion and a pericardial rub were associated with more severe transmural myocardial damage and higher in-hospital mortality. [ABSTRACT FROM AUTHOR]

Published
1998
Full Text
View/download PDF

141. Activation of frozen ferroelectric domain wall by magnetic field sweeping in multiferroic CuFeO2.

Author

Tamatsukuri, H., Mitsuda, S., Nakajima, T., Shibata, K., Kaneko, C., Takehana, K., Imanaka, Y., Terada, N., Kitazawa, H., Prokes, K., Matas, S., Kiefer, K., Paeckel, S., Sokolowski, A., Klemke, B., and Gerischer, S.

Subjects
*DOMAIN walls (Ferromagnetism), *COPPER compounds, *IRON oxides
Abstract

In a ferroelectric helimagnetic phase of a spin-driven multiferroic, CuFeO2, we find irreversibly additive evolution of electric polarization P induced by sweeping magnetic field H under an applied electric field E, despite a large coercive electric field in the phase. From the unpolarized neutron diffraction experiments with in situ P measurements under applied E, we reveal that increment of P is achieved by the variation of an incommensurate magnetic modulation wave number q of the helical magnetic ordering in H sweeping regardless of increasing or decreasing H. Combining this result with the H dependence of the magnetic diffraction intensity and a result of off-bench P measurements, we conclude that the H evolution of P is caused by a change in a (ferroelectric) helicity domain volume fraction by driving the helicity domain wall (DW). Taking into account the results of further detailed P measurements, we provide a speculation for microscopic helicity DW motion. The present study demonstrates the magnetoelectric cross correlation in driving a multiferroic DW: we can activate the frozen ferroelectric DW by means of H sweeping. This is also an achievement of driving an antiferromagnetic DW, which is difficult in conventional antiferromagnets in principle. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

142. Outbreak of Streptococcus pyogenes emm89 ST646 in a head and neck surgical oncology ward.

Author

Hayama B, Harada S, Suzuki M, Doi Y, Nomura Y, Aoki K, Takehana K, Akatsuchi T, Enokida T, Takeda K, Seto A, Mitani H, and Ohkushi D

Subjects
Humans, Male, Female, Middle Aged, Aged, Retrospective Studies, Whole Genome Sequencing, Adult, Polymorphism, Single Nucleotide, Surgical Wound Infection microbiology, Surgical Wound Infection epidemiology, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Aged, 80 and over, Health Personnel statistics & numerical data, Streptococcus pyogenes genetics, Streptococcus pyogenes isolation & purification, Streptococcus pyogenes classification, Streptococcus pyogenes drug effects, Disease Outbreaks, Head and Neck Neoplasms microbiology, Head and Neck Neoplasms surgery, Streptococcal Infections microbiology, Streptococcal Infections epidemiology, Cross Infection epidemiology, Cross Infection microbiology
Abstract

Streptococcus pyogenes causes a variety of human infections, and hospital outbreaks with this pathogen have also been reported. The purpose of this study is to describe the clinical characteristics of an outbreak of S. pyogenes involving 15 patients and four healthcare workers (HCWs), as well as the molecular characteristics of the causative isolates. The course and response to the outbreak were reviewed, and information on the characteristics of the patients was extracted retrospectively from the medical records. Whole-genome sequencing of the 16 causative isolates (14 from patients and two from HCWs) was also performed. All 15 patients were postoperative of head and neck cancer with tracheotomy, and 12 had invasive infections, primarily surgical site infections, all of which resolved without causing serious illness. All but the first case was detected more than 7 days after admission. S. pyogenes was detected in two patients after empiric antimicrobial administration was performed on all inpatients and HCWs, and the outbreak was finally contained in approximately 2 months. All isolates detected in patients and HCWs belonged to emm89 /clade 3, a hypervirulent clone that has emerged worldwide and was classified as sequence type 646. These isolates had single nucleotide polymorphism (SNP) differences of zero to one, indicating clonal transmission. This study demonstrated an outbreak of S. pyogenes emm89 /clade 3 in a ward of patients with head and neck cancer. The global emergence of hypervirulent isolates may increase the risk of outbreaks among high-risk patients., Importance: This study describes an outbreak of Streptococcus pyogenes that occurred in a ward caring for patients with head and neck cancer and tracheostomies. Many cases of invasive infections occurred in a short period, and extensive empiric antimicrobial administration on patients and healthcare workers was performed to control the outbreak. Whole-genome sequencing analysis of the causative strains confirmed that it was a monoclonal transmission of strains belonging to emm89 /clade 3. The epidemiology and clinical characteristics of S. pyogenes infections have changed with the replacement of the prevalent clones worldwide. In the 1980s, there was a reemergence of S. pyogenes infections in high-income countries due to the spread of hypervirulent emm1 strains. emm89 /clade 3 has recently been spreading worldwide and shares common features with emm1, including increased production of two toxins, NADase, and streptolysin O. The outbreak reported here may reflect the high spreading potential and virulence of emm89 /clade 3., Competing Interests: Sohei Harada reports grants from Shionogi paid to his institution and speaker payments from MSD, Shionogi, Daiichi Sankyo, and NISSUI PHARMACEUTICAL outside the submitted work. Yohei Doi reports grants paid to his institution from Entasis and Shionogi; consulting fees paid directly to him from GSK, Meiji Seika Pharma, Shionogi, Gilead, FujiFilm, bioMérieux, Moderna, Abbvie, and Pfizer; and speaker payments from MSD, Shionogi, and Gilead outside the submitted work. Koichi Takeda received speaker payments from Ono Pharmaceutical, Bristol Myers Squibb, AstraZeneca, Chugai, Janssen, and Eisai outside the submitted work. All other authors declare no conflict of interest.

Published
2024
Full Text
View/download PDF

143. Phase transitions and slow spin dynamics of slightly inverted A-site spinel CoAl 2- x Ga x O 4 .

Author

Naka T, Valenta J, Nakane T, Ishii S, Nakayama M, Mamiya H, Takehana K, Tsujii N, Imanaka Y, Matsushita Y, Abe H, Uchikoshi T, and Yusa H

Abstract

We report the properties of an A-site spinel magnet, CoAl 2- x Ga x O 4 , and analyze its anomalous, low-temperature magnetic behavior, which is derived from inherent, magnetically frustrated interactions. Rietveld analysis of the x-ray diffraction profile for CoAl 2- x Ga x O 4 revealed that the metallic ions were randomly distributed in the tetrahedral (A-) and octahedral (B-) sites in the cubic spinel structure. The inversion parameter η could be controlled by varying the gallium (Ga) composition in the range 0.055 ⩽ η ⩽ 0.664. The composition-induced Néel-to-spin-glass (NSG) transition occurred between 0.05 ⩽ η ⩽ 0.08 and was verified by measurements of DC-AC susceptibilities χ and thermoremanent magnetization (TRM) below the Néel transition temperature T N . The relaxation rate and derivative with respect to temperature of TRM increased at both T N and the spin glass (SG) transition temperature T SG . The TRM decayed rapidly above and below these transitions. TRM was highly sensitive to macroscopic magnetic transitions that occurred in both the Néel and SG phases of CoAl 2- x Ga x O 4 . In the vicinity of the NSG boundary, there was a maximum of the TRM relaxation rate at T max < T N ) = (0.08, 4.0 K), where the paramagnetic, Néel, and SG states met. We successfully extracted the relaxation time η ( x ), the anomaly at T max merged with that of the Néel transition at a tricritical point ( η tc , T tc ) = (0.08, 4.0 K), where the paramagnetic, Néel, and SG states met. We successfully extracted the relaxation time τ and other characteristic parameters from the TRM isothermal temporal evolution based on the Weron function derived for a purely stochastic process. To distinguish the magnetic states, we compared our results with previously studied inversion-free A-site spinel, CoRh 2 O 4 , and CoGa 2 O 4 cluster glass. We generated an inversion-temperature phase diagram based on the comprehensive measurements of DC and AC susceptibilities, TRM, and specific heat in the range 0.055 ⩽ η ⩽ 0.664 for CoAl 2- x Ga x O 4 . Based on this phase diagram, we speculate that a NSG quantum critical phase transition occurred at η = 0.050(6). Our findings are consistent with suppression of the long-range order antiferromagnetic state in CoAl 2 O 4 revealed through neutron diffraction studies, even at T << T N ., (© 2023 IOP Publishing Ltd.)

Published
2023
Full Text
View/download PDF

144. Clinical Features, Genome Epidemiology, and Antimicrobial Resistance Profiles of Aeromonas spp. Causing Human Infections: A Multicenter Prospective Cohort Study.

Author

Sakurai A, Suzuki M, Ohkushi D, Harada S, Hosokawa N, Ishikawa K, Sakurai T, Ishihara T, Sasazawa H, Yamamoto T, Takehana K, Koyano S, and Doi Y

Abstract

Background: The genus Aeromonas is increasingly implicated in human infections, but knowledge of its clinical characteristics and antimicrobial resistance profiles has been limited owing to its complex taxonomy., Methods: We conducted a multicenter prospective cohort study of patients with Aeromonas infections at hospitals across Japan. Patients were eligible for inclusion if they had an Aeromonas spp. strain in a clinical culture and were considered infected at the culture site. Clinical data were collected, and isolates underwent susceptibility testing and whole-genome sequencing., Results: A total of 144 patients were included. Hepatobiliary infection accounted for a majority of infections (73% [105 of 144]), which mostly occurred in elderly patients with comorbid conditions, including hepatobiliary complications. The all-cause 30-day mortality rate was 10.0% (95% confidence interval, 4.9%-14.8%). By whole-genome sequencing, 141 strains (98%) belonged to 4 Aeromonas species -A caviae , A hydrophila , A veronii , and A dhakensis- with significant intraspecies diversity. A caviae was predominant in all infection sites except skin and soft tissue, for which A hydrophila was the prevailing species. The genes encoding chromosomally mediated class B, C, and D β-lactamases were harbored by 92%-100% of the isolates in a species-specific manner, but they often lacked association with resistance phenotypes. The activity of cefepime was reliable. All isolates of A hydrophila and A dhakensis carried an mcr-3- like colistin resistance gene and showed reduced susceptibility to colistin., Conclusions: Hepatobiliary tract was the most common infection site of Aeromonas spp., with A caviae being the dominant causative species. The resistance genotype and phenotype were often incongruent for β-lactam agents., Competing Interests: Potential conflicts of interest. M. S. has received a grant and honoraria from KANTO Chemical. S. H. has received a grant from Shionogi and honoraria from Shionogi, MSD, Daiichi Sankyo, and NISSUI Pharmaceutical. Y. D. has received grants from Entasis and Shionogi and has consulted for Moderna, Gilead, Shionogi, Fujifilm, Meiji Seika Pharma, Pfizer, AbbVie, MSD, Gilead, and bioMerieux. All other authors report no potential conflicts., (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)

Published
2023
Full Text
View/download PDF

145. Effects of methacryloyloxydecyl dihydrogen phosphate on bonding of tri-n-butylborane-initiated resin to human enamel.

Author

Hiraba H, Koizumi H, Nogawa H, Takehana K, Yoneyama T, and Matsumura H

Subjects
Humans, Methylmethacrylate chemistry, Boron Compounds chemistry, Methacrylates chemistry, Dental Enamel, Materials Testing, Resin Cements chemistry, Methylmethacrylates chemistry, Dental Bonding methods
Abstract

This study investigated the effect of 10-methacryloyloxydecyl dihydrogen phosphate (MDP) in methyl methacrylate (MMA) monomer on the adhesion of tri-n-butylborane (TBB)-initiated resins (MDP/MMA-TBB resins) to human enamel. Enamel surface conditions were either polished only or phosphatized surfaces. The 1.0, 1.7, and 2.0 mol% MDP/MMA-TBB resins, 4-methacryloxyethyl trimellitate anhydride (4-META)/MMA-TBB resin and MMA-TBB resin were prepared as luting materials. The shear bond strength was determined before and after thermocycles, and the results were compared using non-parametric statistical analyses (each, n=15). The MDP/MMA-TBB resins showed significantly better bond durability to enamel than other resins with or without etching. The 1.7 and 2.0 mol% MDP/MMA-TBB resins were suggested to be the optimum MDP concentrations from pre- and post-thermocycling results for the non-etched specimens. The TBB initiator resin including MDP was shown to be effective in bonding to human enamel, and this effect was enhanced in combination with phosphate treatment.

Published
2023
Full Text
View/download PDF

146. Agarose gel electrophoresis pattern of serum creatine kinase and lactate dehydrogenase isoenzymes in zoo-managed Asian elephants (Elephas maximus).

Author

Takehana K, Adachi M, Ishikawa S, and Yamagishi N

Subjects
Animals, Isoenzymes, Creatine Kinase, L-Lactate Dehydrogenase, Electrophoresis, Agar Gel veterinary, Elephants
Abstract

Serum levels of creatine kinase (CK) and lactate dehydrogenase (LDH) isoenzymes were evaluated in nine zoo-managed Asian elephants (Elephas maximus) using a commercial agarose gel electrophoresis (AGE) kit. CK was separated into two major fractions, CK-BB and CK-MM, along with a small fraction of macroenzyme-CK type 2 (mCK2); CK-MM was the largest fraction. LDH was separated into five fractions (LDH1-5); LDH3 was the largest fraction. Age was negatively and positively correlated with the percentages of CK-BB and CK-MM, respectively, and negatively correlated with CK-BB and mCK2 activities. These results indicate that an AGE kit can be used to evaluate CK and LDH isoenzymes. Routine isoenzyme testing may enable early detection of disease and physiological changes.

Published
2023
Full Text
View/download PDF

147. Prognostic Implications of Sarcoidosis Granulomas　- Insights From the Multicenter Registry, the Japanese Cardiac Sarcoidosis Prognostic Study.

Author

Yoshida S, Nakata T, Naya M, Momose M, Taniguchi Y, Fukushima Y, Moroi M, Okizaki A, Hashimoto A, Kiko T, Hida S, Takehana K, and Nakajima K

Abstract

Background: Definitions of cardiac sarcoidosis (CS) differ among guidelines. Any systemic histological finding of CS is essential for the diagnosis of CS in the 2014 Heart Rhythm Society statement, but not necessary in the Japanese Circulation Society 2016 guidelines. This study aimed to reveal the differences in outcomes by comparing 2 groups, namely CS patients with or without systemic histologically proven granuloma. Methods and Results: This study retrospectively included 231 consecutive patients with CS. CS with granulomas in ≥1 organs was diagnosed in 131 patients (Group G), whereas CS without any granulomas was diagnosed in the remaining 100 patients (Group NG). Left ventricular ejection fraction (LVEF) was significantly reduced in Group NG compared with Group G (44±13% vs. 50±16%, respectively; P=0.001). However, Kaplan-Meier curves showed that major adverse cardiovascular events (MACE)-free survival outcomes were comparable between the 2 groups (log-rank P=0.167). Univariable analyses showed that significant predictors of MACE were Groups G/NG, histological CS, LVEF, and high B-type natriuretic peptide (BNP) or N-terminal pro BNP concentrations, but none of these was significant in multivariable analyses. Conclusions: Overall risks of MACE were similar between the 2 groups despite different manifestations in cardiac dysfunction. The data not only validate the prognostic value of non-invasive diagnosis of CS, but also show the need for careful observation and therapeutic strategy in patients with CS without any granuloma., Competing Interests: None to disclose., (Copyright © 2023, THE JAPANESE CIRCULATION SOCIETY.)

Published
2023
Full Text
View/download PDF

148. Direct detection of elephant endotheliotropic herpesvirus 1 (EEHV1) DNA in heparinized plasma by loop-mediated isothermal amplification.

Author

Takehana K and Matsuno K

Subjects
Animals, DNA, Elephants, Herpesviridae Infections diagnosis, Herpesviridae Infections veterinary, Herpesviridae genetics
Abstract

Elephant endotheliotropic herpesvirus (EEHV) causes a fatal hemorrhagic disease and is a significant cause of mortality in juvenile Asian elephants. A loop-mediated isothermal amplification (LAMP) method was developed to rapidly diagnose EEHV viremia. However, extracting DNA from whole blood samples to perform LAMP hampers diagnosis in a field setting. Here, we established the Direct-LAMP method, using heparinized plasma without extracting the DNA to speed up and simplify the test. EEHV-positive specimens were tested using the Direct-LAMP. The detection limit was calculated to be 10 1.3 copies/μL using the mimetic samples, which was almost identical to the value determined in LAMP in which DNA was extracted. Hence, the Direct-LAMP provided a more rapid diagnosis to save, which could prevent elephant deaths.

Published
2023
Full Text
View/download PDF

149. The serum activities of alkaline phosphatase isoenzymes measured using two approved methods in zoo-managed Asian elephants (Elephas maximus).

Author

Takehana K, Adachi M, Ishikawa S, and Yamagishi N

Subjects
Animals, Alkaline Phosphatase, Chemistry, Clinical, Coloring Agents, Animals, Zoo, Isoenzymes, Elephants
Abstract

The approved Japanese measurement method of circulating alkaline phosphatase (ALP) has changed from that of the Japan Society of Clinical Chemistry (JSCC) to that of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). We measured the serum levels of total ALP (t-ALP) and those of the isoenzymes ALP2 and ALP3 in 50 Asian elephant (Elephas maximus) specimens using both methods. The activities determined by the IFCC method were roughly one-third lower than those determined by the JSCC method. We present conversion formulae. Our results enable comparisons of historical and current data on serum ALP activities in endangered, zoo-managed Asian elephants.

Published
2023
Full Text
View/download PDF

150. The Correlation between the Vascular Calcification Score of the Coronary Artery and the Abdominal Aorta in Patients with Psoriasis.

Author

Huynh TN, Yamazaki F, Kishimoto I, Tanaka A, Son Y, Ozaki Y, Takehana K, and Tanizaki H

Abstract

Psoriasis is known as an independent risk factor for cardiovascular disease due to its chronic inflammation. Studies have been conducted to evaluate the progress of atherosclerotic plaques in psoriasis. However, inadequate efforts have been made to clarify the relationship between atherosclerosis progress in coronary arteries and other important blood vessels. For that reason, we investigated the correlation and development of the coronary artery calcification score (CACS) and the abdominal aortic calcification score (AACS) during a follow-up examination. Eighty-three patients with psoriasis underwent coronary computed tomography angiography (CCTA) for total CACS and abdominal computed tomography (AbCT) for total AACS. PASI score, other clinical features, and blood samples were collected at the same time. The patients' medical histories were also retrieved for further analysis. Linear regression was used to analyze the CACS and AACS associations. There was a moderate correlation between CACS and AACS, while both calcification scores relatively reflected the coronary plaque number, coronary stenosis number, and stenosis severity observed with CCTA. Both calcification scores were independent of the PASI score. However, a significantly higher CACS was found in psoriatic arthritis, whereas no similar phenomenon was recorded for AACS. To conclude, both CACS and AACS might be potential alternative tests to predict the presence of coronary lesions as confirmed by CCTA.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results