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To achieve the most energy-efficient operation, this brief presents a circuit design technique for separating the power supply voltage (VDD) of flip-flops (FFs) from that of combinational circuits, called the higher voltage FF (HVFF). Although VDD scaling can reduce the energy, the minimum operating voltage (VDDmin) of FFs prevents the operation at the optimum supply voltage that minimizes the energy, because the VDDmin of FFs is higher than the optimum supply voltage. In HVFF, the VDD of combinational logic gates is reduced below the VDDmin of FFs while keeping the VDD of FFs at their VDDmin. This makes it possible to minimize the energy without power and delay penalties at the nominal supply voltage (1.2 V) as well as without FF topological difications. A 16-bit integer unit with HVFF is fabricated in a 65-nm CMOS process, and measurement results show that HVFF reduces the minimum energy by 13% compared with the conventional operation, which is 1/10 times smaller than the energy at the nominal supply voltage. [ABSTRACT FROM AUTHOR]

Aims This study was designed to determine, using electron-beam CT, whether there are morphological abnormalities in patients with the Brugada syndrome and to elucidate the relationship between those abnormalities and arrhythmogenesis.Methods and Results Twenty-six consecutive patients with the Brugada syndrome and 23 age- and gender-matched control subjects (controls) were evaluated for morphological abnormalities using electron beam CT. Electron beam CT demonstrated morphological abnormalities of the right ventricle in 21 (81%) of 26 patients, but in only two (9%) of 23 controls. The sites of morphological abnormalities were the right ventricular outflow tract area in 17 patients and the inferior wall of the right ventricle in four patients. Of the seven patients with monoform premature ventricular contractions recorded only in the acute phase, four of the five patients with premature ventricular contractions from the right ventricular outflow tract area had morphological abnormalities in the right ventricular outflow tract area, and the other two patients with premature ventricular contractions from the inferior wall of the right ventricle had morphological abnormalities in the inferior wall of the right ventricle.Conclusion The sites of morphological abnormalities detected by electron beam CT in patients with the Brugada syndrome were related to the origins of premature ventricular contractions recorded only in the acute phase, which may trigger ventricular fibrillation. These morphological abnormalities may be related to arrhythmogenic substrates in patients with the Brugada syndrome. [ABSTRACT FROM PUBLISHER]