118 results on '"Tagliabue, Anna"'
Search Results
102. Modelling blood flows in the heart: extended Nitsche's method for the treatment of the valves as generalized boundary conditions
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Tagliabue, Anna, Dede', Luca, Quarteroni, Alfio, Nithiarasu, Perumal, and Budyn, Elisa
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Quantitative Biology::Tissues and Organs ,Physics::Medical Physics ,extended Nitsche's method ,heart modeling ,fluid dynamics ,weak imposition of boundary conditions - Abstract
We investigate the blood flow inside idealized left ventricles with prescribed wall movement by defining a formulation of boundary conditions for the Navier-Stokes equations accounting for the valves. Specifically, we consider an extended Nitsche’s method for the treatment of general boundary conditions modelling the mitral and aortic valves. The proposed weak formulation includes boundary terms which provide a stabilizing effect for numerical instabilities occurring due to backflow regimes. We present and discuss numerical results for blood flows in left ventricles, both under healthy conditions and in dilatated cardiomyopathy, for which we highlight the effectiveness of the proposed method.
103. Cognitive-behavioral treatment reduces attrition in treatment-resistant obese women: Results from a 6-month nested case-control study
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Vinai, Piergiuseppe, Martinelli, Valentina, Cinzia Ferraris, Trentani, Claudia, Repossi, Ilaria, and Tagliabue, Anna
104. Fluid dynamics of an idealized left ventricle: the extended Nitsche's method for the treatment of heart valves as mixed time varying boundary conditions
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Tagliabue, Anna, Dede', Luca, and Quarteroni, ALFIO MARIA
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Navier–Stokes equations ,extended Nitsche’s method ,left ventricle ,extended Nitsche's method ,mixed time varying boundary conditions ,fluid dynamics ,fluid dynamics ,heart modelling ,Navier-Stokes equations - Abstract
In this work, we study the blood flow dynamics in idealized left ventricles (LV) of the human heart modelled by the Navier-Stokes equations with mixed time varying boundary conditions. The latter are introduced for simulating the functioning of the aortic and mitral valves. On the basis of the extended Nitsche's method firstly presented in [Juntunen and Stenberg, Mathematics of Computation, 2009], we propose a formulation allowing an efficient and straightforward numerical treatment of the opening and closing phases of the heart valves that are associated with different kind of boundary conditions, namely, natural and essential, switching during each heartbeat. Moreover, our formulation already includes terms preventing the numerical instabilities associated to backflow divergence, that is, nonphysical reinflow at the valves. We present and discuss numerical results for the LV obtained by means of isogeometric analysis for the spatial approximation with the aim of both analysing the formulation and showing the effectiveness of the approach. In particular, we show that the formulation allows to reproduce meaningful results even in idealized LV. Copyright (C) 2017 John Wiley & Sons, Ltd.
105. MATHICSE Technical Report : A complex blood flow patterns in an idealized left ventricle: a numerical study
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Tagliabue, Anna, Dede', Luca, Quarteroni, Alfio, and MATHICSE-Group
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mixed time-varying boundary ,left ventricle ,Quantitative Biology::Tissues and Organs ,extended Nitsche's method ,Isogeometric Analysis ,heart modeling ,fluid dynamics ,valves modeling ,conditions - Abstract
In this paper, we study the blood flow dynamics in a three-dimensional (3D) idealized left ventricle of the human heart whose deformation is driven by muscle contraction and relaxation in coordination with the action of the mitral and aortic valves. We propose a simplified but realistic mathematical treatment of the valves function based on mixed time-varying boundary conditions (BCs) for the Navier-Stokes equations modeling the flow. These switching in time BCs, from natural to essential and viceversa, model either the open or the closed configurations of the valves. At the numerical level these BCs are enforced by means of the extended Nitsche's method [A. Tagliabue et al., MATHICSE report, 2015]. Numerical results for 3D idealized left ventricle obtained by means of Isogeometric Analysis are presented, discussed in terms of both instantaneous and phase-averaged quantities of interest and validated against those available in literature, both experimental and computational. The complex blood flow patterns are analysed to describe the characteristic fluid properties, to show the transitional nature of the flow, and to highlight its main features inside the left ventricle. The sensitivity of the intraventricular flow patterns to the mitral valve properties is also investigated.
106. MATHICSE Technical Report: Fluid dynamics of an idealized left ventricle: the extended Nitsche’s method for the treatment of heart valves as mixed time varying boundary conditions
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Tagliabue, Anna, Dede', Luca, Quarteroni, Alfio, and MATHICSE-Group
- Abstract
In this work, we study the blood flow dynamics in idealized left ventricles (LV)of the human heart modelled by the Navier-Stokes equations with mixed time varying boundary conditions (BCs). The latter are introduced for simulating the functioning of the aortic and mitral valves. Based on the extended Nitsche’s method firstly presented in [Juntunen and Stenberg, Mathematicsof Computation, 2009], we propose a formulation allowing an efficient and straight forward numerical treatment of the opening and closing phases of the heart valves which are associated to different kind of BCs, namely natural and essential. Moreover, our formulation includes terms preventing the numerical instabilities associated to back flow divergence, i.e. nonphysical reinflow at the valves. We present and discuss numerical results for the LV obtained by means of Isogeometric Analysis for the spatial approximation with the aim of both analysing the formulation and showing the effectiveness of the approach. In particular, we show that the formulation allows to reproduce meaningful results even in idealized LV.
107. MATHICSE Technical Report : Nitsche’s method for parabolic Partial Differential Equations with mixed time varying boundary conditions
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Tagliabue, Anna, Dede', Luca, Quarteroni, Alfio, and MATHICSE-Group
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Nitsche’s method ,Mixed time varying boundary conditions ,Parabolic problems ,Stability analysis ,Finite Element method - Abstract
We investigate a finite element approximation of an initial boundary value problem associated with parabolic Partial Differential Equations endowed with mixed time varying boundary conditions, switching from essential to natural and viceversa. The switching occurs both in time and in different portions of the boundary. For this problem, we apply and extend the Nitsche’s method presented in [Juntunen and Stenberg, Mathematics of Computation, 2009] to the case of mixed time varying boundary conditions. After proving existence and numerical stability of the full discrete numerical solution obtained by using the θ-method for time discretization, we present and discuss a numerical test that compares our method to a standard approach based on remeshing and projection procedures.
108. Modeling the fluid dynamics of the heart: from blood flows in idealized left ventricles to patient-specific aortic valve simulations
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Dede', Luca, Faggiano, Elena, Fedele, Marco, Tagliabue, Anna, Deparis, Simone, Forti, Davide, Quarteroni, Alfio, Bertoglio, C., Deisenhofer, I., Schwaiger, M., and Wall, W.
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Physics::Fluid Dynamics ,Quantitative Biology::Tissues and Organs ,Physics::Medical Physics ,Heart modeling ,Blood flows ,Fluid Dynamics ,Aortic valve ,Numerical simulation ,Finite Element method - Abstract
The computational fluid dynamics of the heart represents a challenging task both in terms of mathematical and numerical modeling; this is mainly due to the pulsatile nature of the blood flow, to its complex interaction with the valves, and, more in general, to the reciprocal action of the components responsible for the heart functioning. Even if one focuses on the study of the left ventricle, the blood flow patterns result to be significantly dependent on the mechanical contraction and relaxation of the muscle, on the conformation of the chamber, and on the interaction with the valves, which define a complex fluid-structure interaction problem. In this respect, also the blood flow in the aorta, and hence in the downstream circulation, is strongly affected by the aortic valve, whose behavior should be suitably mathematically and numerically modeled. In this work, we firstly focus on the study of the fluid dynamics inside the left ventricle in idealized configurations, for which we propose a mathematical model based on the Navier-Stokes equations endowed with mixed, time-dependent boundary conditions, which allow a simplified treatment of the aortic and mitral valves’ behavior. In this idealized setting, we perform numerical simulations which highlight the role and influence of modeling the valves to study and characterize the blood flow patterns inside the ventricle, as well as other parameters of clinical relevance. In addition, we consider a reduced, patient-specific fluid-structure-interaction model for the simulation of the blood flow through the aortic valve. Specifically, we propose an efficient coupled model which represents the valve dynamics by means of a zero-dimensional (0D) equation with the opening angle as primitive variable, while the blood flow by means of the full 3D Navier-Stokes equations. In this coupled model, the valve’s leaflets, which are reconstructed from MRI data of the open and closed configurations for a specific patient, influence the Navier-Stokes equations by means of resistive immersed surfaces, whose position depends on the opening angle of the valve. Moreover, the dynamics of the valve described by the 0D model is dependent on the velocity and pressure variables, specifically on the pressure jump and the flow rate through the valve itself. We per form patient-specific numerical simulations of the aortic valve based on this reduced 3D-0D model, for which we highlight its ability to correctly capture the fluid dynamics indicators expected for the patient.
109. Ketogenic diet in children with intractable epilepsy: what about resting energy expenditure and growth?
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Bertoli, Simona, Battezzati, Alberto, and Tagliabue, Anna
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- 2013
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110. Microbiota-gut brain axis involvement in neuropsychiatric disorders
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Hervé M. Blottière, Emilio Russo, Sigrid Pedersen, Francesca Ronchi, Luigi Francesco Iannone, Gaia Luongo, Federico Zara, Cinzia Ferraris, P. Mainardi, Anna Tagliabue, Alberto Preda, Gerard Clarke, Kaja Kristine Selmer, Elisa Santocchi, Stefania Provasi, Vincenzo Belcastro, Carmen Giordano, Alberto Verrotti, Pietro Baldelli, Carlo Minetti, Rita Citraro, Diego Albani, Pasquale Striano, Andrea Petretto, Paola Iannetti, Marco Carotenuto, Jakob Zimmermann, Nicola Segata, Annamaria Cattaneo, Alberto Spalice, Letizia Guiducci, Sanjay M. Sisodiya, Iannone, Luigi Francesco, Preda, Alberto, Blottière, Hervé M, Clarke, Gerard, Albani, Diego, Belcastro, Vincenzo, Carotenuto, Marco, Cattaneo, Annamaria, Citraro, Rita, Ferraris, Cinzia, Ronchi, Francesca, Luongo, Gaia, Santocchi, Elisa, Guiducci, Letizia, Baldelli, Pietro, Iannetti, Paola, Pedersen, Sigrid, Petretto, Andrea, Provasi, Stefania, Selmer, Kaja, Spalice, Alberto, Tagliabue, Anna, Verrotti, Alberto, Segata, Nicola, Zimmermann, Jakob, Minetti, Carlo, Mainardi, Paolo, Giordano, Carmen, Sisodiya, Sanjay, Zara, Federico, Russo, Emilio, Striano, Pasquale, University of Catanzaro, University of Genoa (UNIGE), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, University College Cork (UCC), IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri', Saint Anna Hospital, Partenaires INRAE, Università degli studi della Campania 'Luigi Vanvitelli', King's College, University of Pavia, University of Bern, Ordine dei Tecnologi Alimentari Campania e Lazio, Stella Maris Foundation, Institute of Clinical Physiology, National Council of Research, University of Genova, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Oslo University Hospital [Oslo], Istituto Giannina Gaslini, University of Laquila, University of Trento, Kolfarma SRL, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta' (CMIC), Politecnico di Milano [Milan] (POLIMI), Department of Clinical and Experimental Epilepsy, and UCL Institute of Neurology
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microbiota-gut brain axis ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Central nervous system ,Gut–brain axis ,Inflammation ,Bidirectional communication ,digestive system ,03 medical and health sciences ,fluids and secretions ,0302 clinical medicine ,Ketogenic diet ,inflammation ,manipulating microbiota ,metabolomics ,neuropsychiatric disorders ,Central Nervous System Diseases ,medicine ,microbiota-gut brain axi ,Humans ,Pharmacology (medical) ,Ketogenic diet, inflammation, manipulating microbiota, metabolomics, microbiota-gut brain axis, neuropsychiatric disorders ,business.industry ,General Neuroscience ,Multiple sclerosis ,Mental Disorders ,medicine.disease ,3. Good health ,030227 psychiatry ,Clinical neurology ,Gastrointestinal Microbiome ,stomatognathic diseases ,medicine.anatomical_structure ,Clinical evidence ,Immunology ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery ,metabolomic - Abstract
International audience; Introduction: The microbiota-gut brain (MGB) axis is the bidirectional communication between the intestinal microbiota and the brain. An increasing body of preclinical and clinical evidence has revealed that the gut microbial ecosystem can affect neuropsychiatric health. However, there is still a need of further studies to elucidate the complex gene-environment interactions and the role of the MGB axis in neuropsychiatric diseases, with the aim of identifying biomarkers and new therapeutic targets, to allow early diagnosis and improving treatments. Areas covered: To review the role of MGB axis in neuropsychiatric disorders, prediction and prevention of disease through exploitation, integration, and combination of data from existing gut microbiome/microbiota projects and appropriate other International '-Omics' studies. The authors also evaluated the new technological advances to investigate and modulate, through nutritional and other interventions, the gut microbiota. Expert opinion: The clinical studies have documented an association between alterations in gut microbiota composition and/or function, whereas the preclinical studies support a role for the gut microbiota in impacting behaviors which are of relevance to psychiatry and other central nervous system (CNS) disorders. Targeting MGB axis could be an additional approach for treating CNS disorders and all conditions in which alterations of the gut microbiota are involved.
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- 2019
111. Use of online and paper-and-pencil questionnaires to assess the distribution of orthorexia nervosa, muscle dysmorphia and eating disorders among university students: can different approaches lead to different results?
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Gorrasi ISR, Ferraris C, Degan R, Daga GA, Bo S, Tagliabue A, Guglielmetti M, Roppolo M, Gilli G, Maran DA, and Carraro E
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- Cross-Sectional Studies, Health Behavior, Humans, Muscles, Reproducibility of Results, Students, Surveys and Questionnaires, Universities, Feeding and Eating Disorders diagnosis, Feeding and Eating Disorders epidemiology, Orthorexia Nervosa
- Abstract
Purpose: Administration of questionnaires to assess the diffusion of disordered eating behaviours via the web is becoming common today. The aim of this study is to assess whether two different approaches of administering a test to assess traits of eating disorders (EDs), orthorexia nervosa (ON) and muscle dysmorphia (MD) by email recruitment and online completion (web-based survey-WBS) and by in person recruitment and paper-and-pencil completion (paper-based survey-PBS), gives different results., Methods: During 2 consecutive academic years, a self-reported questionnaire consisting of questions about personal characteristics and three tests for the evaluation of ON (ORTO-15), MD (MDDI-ITA), and EDs (EAT-26) were administered to two groups of undergraduates, respectively, as a WBS and a PBS., Results: The WBS response rate was 6.7% (N = 137), and the PBS response rate was 86.5% (N = 372). The WBS group showed a statistically significant higher prevalence of students with eating disordered behaviours (21.2% vs 5.4%) and registered a higher mean score on the EAT-26 test (13.5 ± 11.1 vs 6.0 ± 8.0); no differences between the two groups emerged for ON and MD prevalence and test scores. Moreover, in the WBS group, the number of students with one or more tests with test scores above the cut-off values was significantly higher (46.0% vs 32.3%)., Conclusion: The choice of the approach to administer a questionnaire to assess the diffusion of EDs and related issues must take into account all the factors that can result in selection bias and that can affect the reliability of the results., Level of Evidence: Level V, descriptive cross-sectional survey., (© 2021. The Author(s).)
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- 2022
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112. Traits of orthorexia nervosa and muscle dysmorphia in Italian university students: a multicentre study.
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Gorrasi ISR, Bonetta S, Roppolo M, Abbate Daga G, Bo S, Tagliabue A, Ferraris C, Guglielmetti M, Arpesella M, Gaeta M, Gallé F, Di Onofrio V, Liguori F, Liguori G, Gilli G, and Carraro E
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- Cross-Sectional Studies, Feeding Behavior, Health Behavior, Humans, Italy epidemiology, Muscles, Prevalence, Students, Surveys and Questionnaires, Feeding and Eating Disorders epidemiology, Universities
- Abstract
Purpose: This study aimed to evaluate the prevalence of traits of orthorexia nervosa (ON) and muscle dysmorphia (MD) in a group of undergraduates, investigate the associations between the risk of these conditions and the type of university course attended, the individual characteristics (gender, BMI, amount of physical activity, supplements and medicines use, dieting) and the risk of eating disorders (EDs)., Methods: A self-reported questionnaire consisting of a socio-demographic section and three tests validated for the evaluation of a risk of ON (ORTO-15), MD (MDDI-ITA) and EDs (EAT-26) was completed by 918 students from three Italian universities., Results: 29.0% of participants demonstrated traits of ON and 5.0% of MD, without differences in prevalence in the three areas of study investigated (health-scientific, economic-humanistic, sport sciences); students of sport sciences exhibited a significantly higher score for MDDI-ITA (F = 6.493, p = 0.002). Participants with ON and MD traits were more on a diet (OR = 0.47, p ≤ 0.001 and OR = 0.428, p = 0.020, respectively) and showed a higher prevalence of EDs risk (OR = 3.55, p < 0.001 and OR = 10.23, p ≤ 0.001, respectively). The simultaneous presence of ON, MD, and EDs traits was seen in 5.4% of the students and the three test scores were correlated., Conclusions: The prevalence of ON and MD traits was found similar to that reported in the literature on undergraduates. Some associations observed improvement in the knowledge about these conditions, especially the association of participants with ON and MD traits with dieting and EDs traits and the correlation of the three test scores suggests a connection among these potential conditions., Level of Evidence: Level V, descriptive cross-sectional survey.
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- 2020
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113. Glucose transporter 1 deficiency syndrome: nutritional and growth pattern phenotypes at diagnosis.
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Bertoli S, Masnada S, De Amicis R, Sangiorgio A, Leone A, Gambino M, Lessa C, Tagliabue A, Ferraris C, De Giorgis V, Battezzati A, Zuccotti GV, Veggiotti P, and Mameli C
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- Child, Glucose Transporter Type 1 genetics, Humans, Infant, Newborn, Monosaccharide Transport Proteins genetics, Phenotype, Carbohydrate Metabolism, Inborn Errors diagnosis, Carbohydrate Metabolism, Inborn Errors genetics, Diet, Ketogenic, Epilepsy
- Abstract
Background/objectives: Glucose Transporter 1 Deficiency Syndrome (GLUT1-DS; OMIM #606777) is a rare disease caused by dominant mutations in SLC2A1 encoding GLUT1, which is a ubiquitous transporter of glucose across plasma membranes, particularly across the blood-brain barrier. Hypoglycorrhachia symptoms are the cornerstones of GLUT1-DS, but delayed growth has also been suggested. This led us to investigate, at diagnosis, the relationship between the glycemia/glycorrhachia ratio and the nutritional and growth pattern phenotype of 30 GLUT-DS patients., Subjects/methods: An assessment was made of body weight (BW), body length/height (BL, BH) and body composition by anthropometry and DEXA, and the results put with BL and BW at birth, genetic target, glycemia, insulinemia, and glycorrhachia values., Results: At birth, 21% of patients had a BW below -1.645 z-score, whereas no patients had BL below the reference values. At diagnosis 23% of the patients had an impaired nutritional status, 19.2% and 3.8% being respectively underweight and overweight/obese; 10%, all under 10 years old, had BL/BH below -1.645 z-score, with no specific features related to body composition. Finally, there was no association between glycemia, glycorrhachia, and growth phenotype., Conclusions: GLUT1-DS is associated with impaired BW but not BL intrauterine growth, with a slower than normal pattern of growth rather than growth failure. These data could be useful for the interpretation of any long-term effects of the ketogenic diet, e.g. nutritional and growth pattern decline.
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- 2020
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114. Complex blood flow patterns in an idealized left ventricle: A numerical study.
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Tagliabue A, Dedè L, and Quarteroni A
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- Humans, Models, Cardiovascular, Coronary Circulation physiology, Numerical Analysis, Computer-Assisted, Ventricular Function physiology
- Abstract
In this paper, we study the blood flow dynamics in a three-dimensional (3D) idealized left ventricle of the human heart whose deformation is driven by muscle contraction and relaxation in coordination with the action of the mitral and aortic valves. We propose a simplified but realistic mathematical treatment of the valves function based on mixed time-varying boundary conditions (BCs) for the Navier-Stokes equations modeling the flow. These switchings in time BCs, from natural to essential and vice versa, model either the open or the closed configurations of the valves. At the numerical level, these BCs are enforced by means of the extended Nitsche's method (Tagliabue et al., Int. J. Numer. Methods Fluids, 2017). Numerical results for the 3D idealized left ventricle obtained by means of Isogeometric Analysis are presented, discussed in terms of both instantaneous and phase-averaged quantities of interest and validated against those available in the literature, both experimental and computational. The complex blood flow patterns are analysed to describe the characteristic fluid properties, to show the transitional nature of the flow, and to highlight its main features inside the left ventricle. The sensitivity of the intraventricular flow patterns to the mitral valve properties is also investigated.
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- 2017
- Full Text
- View/download PDF
115. Cognitive-behavioral treatment reduces attrition in treatment-resistant obese women: results from a 6-month nested case-control study.
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Tagliabue A, Repossi I, Trentani C, Ferraris C, Martinelli V, and Vinai P
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- Adult, Case-Control Studies, Cohort Studies, Female, Humans, Middle Aged, Obesity diet therapy, Treatment Outcome, Cognitive Behavioral Therapy methods, Diet Therapy methods, Obesity therapy, Patient Compliance, Weight Loss
- Abstract
Objective: The aim of this nested case-control study was to compare the effectiveness of cognitive-behavioral treatment (CBT) for treatment-resistant obese (body mass index [BMI] ≥ 30 kg/m²) women compared with standard dietary treatment. The main outcome measures were attrition and weight loss success., Methods: We designed a 6-month case-control study, nested within a cohort of adult (age ≥ 18 years) treatment-resistant (history of at least two previous diet attempts) obese women. Cases were 20 women who were offered CBT sessions. Controls (n=39) were randomly selected from the source population and matched to cases in terms of baseline age, BMI, and number of previous diet attempts., Results: Compared with controls, cases were significantly more likely to complete the 6-month program in both age-adjusted (odds ratio [OR]=2.94, 95% confidence interval [CI]=1.05-8.97) and multivariate-adjusted (OR=2.77, 95% CI=1.02-8.34) analyses. In contrast, cases were not more likely to achieve weight loss success in age-adjusted (OR=1.32, 95% CI=0.86-1.67) and multivariate-adjusted (OR=1.21, 95% CI=0.91-1.44) analyses., Conclusions: Compared with a standard dietary treatment, CBT was significantly more effective in reducing attrition in treatment-resistant obese women, without differences in terms of weight loss success.
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- 2015
116. Clinical and psychological features of normal-weight women with subthreshold anorexia nervosa: a pilot case-control observational study.
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Tagliabue A, Ferraris C, Martinelli V, Pinelli G, Repossi I, and Trentani C
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- Adult, Anorexia Nervosa diagnosis, Anthropometry, Body Mass Index, Case-Control Studies, Female, Humans, Obsessive-Compulsive Disorder diagnosis, Obsessive-Compulsive Disorder physiopathology, Obsessive-Compulsive Disorder psychology, Outpatients psychology, Pilot Projects, Thinness diagnosis, Young Adult, Anorexia Nervosa physiopathology, Anorexia Nervosa psychology, Body Weight, Thinness physiopathology, Thinness psychology
- Abstract
Objective: Weight preoccupations have been frequently reported in normal-weight subjects. Subthreshold anorexia nervosa (s-AN, all DSM IV TR criteria except amenorrhea or underweight) is a form of eating disorder not otherwise specified that has received scarce scientific attention. Under a case-control design we compared the general characteristics, body composition, and psychopathological features of normal-weight patients with s-AN with those of BMI- and sex-matched controls., Design: Participants in this pilot study included 9 normal-weight women who met the DSM IV TR criteria for s-AN and 18 BMI-matched normal-weight controls. The general characteristics of the study participants were collected by questionnaire. Body composition was measured by bioelectrical impedance. Behavioral and psychological measures included the standardized symptom checklist (SCL-90-R) and the eating disorder inventory (EDI-2)., Results: There were no differences in age, education, employment status, marital status, and history of previous slimming treatment in the two study groups. In addition, anthropometric measures and body composition of s-AN patients and BMI-matched normal weight controls were not significantly different. In the s-AN subgroup, we found a significant relationship between waist circumference and the SCL-90-R obsessivity-compulsivity scale (n=9, r=-0.69, p<0.05). After multiple regression analysis, the SCL-90-R obsessivity-compulsivity scale (beta = 0.61, t=2.7, p=0.017) was the only independent predictor of the presence s-AN in our study cohort., Conclusions: These pilot results suggest that psychopathological criteria (particularly related to the obsessivity-compulsivity dimension) may be more useful than anthropometric measures for screening of s-AN in normal-weight women.
- Published
- 2012
117. The ketogenic diet: from molecular mechanisms to clinical effects.
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Freeman J, Veggiotti P, Lanzi G, Tagliabue A, and Perucca E
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- Adolescent, Child, Clinical Trials as Topic, Dietary Fats adverse effects, Humans, Dietary Fats therapeutic use, Epilepsy diet therapy, Ketosis
- Abstract
Recent years have witnessed an increased interest from pediatric neurologists, neuropediatricians, epileptologists and general neurologists in the use of the ketogenic diet (KD) for the management of refractory epilepsies, particularly in children and adolescents. This article summarizes current knowledge on various issues related to its use, as discussed at a recent international workshop. Aspects discussed in some detail include (i) the putative mechanisms responsible for the diet's anticonvulsant effects,based on results of biochemical and neurophysiological studies in experimental models; (ii) consensus and controversies on the modalities of initiation of the diet, and different protocols of implementation; (iii) indications and contraindications; (iv) efficacy data, also in relation to seizure type, syndromic form and patients age; (v) adverse effects; (vi) methodological aspects related to assessment of the diet's clinical effects, and perspectives for future research. Overall, the data reviewed indicate that considerable advances have been made in understanding the modes of action of the diet, its efficacy and tolerability profiles and its potential role in different types of epilepsy. Although clinical studies performed to date have important methodological limitations, including suboptimally characterized patients' populations and an uncontrolled design, a number of innovative, prospective randomized study protocols have been recently proposed and are being implemented. The results of these will hopefully provide much needed high-quality information to better define the role of the diet in the treatment algorithms in different epilepsy syndromes.
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- 2006
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118. [Nutritional status and bone mineral mass in children treated with ketogenic diet].
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Bertoli S, Striuli L, Testolin G, Cardinali S, Veggiotti P, Salvatori GC, and Tagliabue A
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- Absorptiometry, Photon, Adolescent, Age Factors, Body Height, Body Mass Index, Body Weight, Child, Child, Preschool, Epilepsy blood, Female, Humans, Infant, Newborn, Ketone Bodies blood, Male, Retrospective Studies, Sex Factors, Bone Density, Epilepsy diet therapy, Ketones therapeutic use, Nutritional Status
- Abstract
Ketogenic diet (KD) is a high fat (90%), low carbohydrate (3%) diet used to treat refractory seizures in child. This highly unbalance diet could damage nutritional status. The aim of this study is to evaluate if KD can affect on growth and on mineral status in child. Seven child (1 females and 6 males) age between 3-16 years were retrospectively studied to assess nutritional status during KD; we evaluated anthropometric measurements (weight, height, skinfold and circumferences), bone mineral content and bone mineral density, using x-ray energy absorptiometry (DXA) and some biochemical parameters. We have not found any short term modifications (six months) concerning growth, and biochemical parameters studied. KD could worsen bone mineral status.
- Published
- 2002
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