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DTC is known for its fast torque response, robustness against parameter variation and simple implementation. The performance of DTC drive, however, deteriorates at low speed due to its poor flux regulation. This paper proposes a technique to improve the flux regulation, and it only requires minor changes to the index of the look-up table. With this method, the simple structure of the DTC is retained and the same look-up table can be used. Experimental results are presented to show the effectiveness and viability of the proposed method. It is shown that flux regulation at low speed is improved and rated flux can be established even at zero speed; improvement in the flux regulation significantly improves the torque dynamic.

This work investigates a linear model predictive control (MPC) in conjunction with a voltage source inverter with a grid-interfacing passive filter. In an ideal grid, standard linear MPC demonstrates fast transient and excellent steady-state performance while respecting the imposed constraints. Nevertheless, its direct application onto the grid-connected converters operating with a distorted grid (e.g. islanded microgrid and marine vessel grid) or with applications that require harmonic current injection would encounter steady-state tracking error [1, 2], leading to unfulfilled application objectives. This shortfall is first demonstrated here using simulation, and then a solution based on plug-in repetitive control (RC) is proposed and investigated. With some assumptions simplifying this investigation, the resulted linear MPC with RC plug-in successfully mitigates the steady-state tracking errors while preserving the applicability of the multi-parametric quadratic-programming — the explicit implementation method that makes the linear MPC feasible in fast sampling applications. It is worth noting here that the notable features of MPC such as simple tuning, fast current response close to the physical limits of the system, and constraints consideration are retained and this makes the proposed control method a powerful alternative to the established grid-converter control techniques.

—This article proposes a novel zero-current switching series resonant inverter-fed voltage multiplier based high-voltage DC-DC converter. The series resonant inverter in the proposed topology has two power switches (insulated-gate bipolar transistors), two resonant capacitors, and only one high-voltage transformer with center-tapped primary windings. The power switches are connected in the form of a half-bridge network. The leakage inductances of the transformer's primary windings together with resonant capacitors form two series resonant circuits. The series resonant circuits are fed alternately by operating power switches with an interleaved half-switching cycle. The secondary winding of the high-voltage transformer is connected to a voltage multiplier circuit to rectify and boost the voltage. The converter operates in discontinuous conduction mode, and its output voltage is regulated by pulse-frequency modulation. Therefore, all the power switches turn ON and OFF at the zero-current switching c...

This paper presents a new technique to minimize the torque ripples inherited in DTC of induction motor. The typical discrete-based DTC imposes delay time which frequently allows the torque to overshoot beyond hysteresis bands. This triggers the selection of reverse voltage vectors which, in turn, cause large torque decrements. The torque ripples become of great significance at low speeds where torque overshoot is most likely to occur due to steep positive torque slope. A multi-level DC link voltage is proposed to vary the DC voltage of Voltage Source Inverter (VSI) according to motor's speed. By varying the DC link voltage, the torque slopes can be controlled and, hence, the torque overshoots can mostly be avoided. Therefore, the torque ripples are significantly minimized. The viability of proposed technique has been validated using MATLAB/Simulink software. Results show the proposed technique yielded over 50% reduction in the RMS torque ripples while maintaining a low switching frequency.

Renewable energy demand increases due to environmentally friendly. Power electronics development enhance the power quality produced. Standalone application multilevel inverter can help in improve rural area which is no electrified. For a multilevel inverter, the output required low total harmonics distortion and voltage boosting character. However, the conventional multilevel inverter are high distortion with high switching frequency. This paper is presenting multilevel inverter with selective harmonics elimination on reduce total harmonics distortion (THD) apply in standalone concept. 9-level cascaded H-bridge multilevel inverter is applied with optimize harmonics stepped waveform (OSHW) to compare performance with sinusoidal pulse width modulation (SPWM). In OSHW, selective harmonics elimination is used to reduce the low harmonics component which is 3rd, 5th and 7th harmonics. Genetic algorithm are applied to solve the non-linear equation on solving the best switching angle. The result show OHSW have lower THD then SPWM. Meanwhile OHSW eliminated low harmonics component by the aid of genetic algorithm which exist due to the low switching frequency.

The nine-switch converter topology with 2 three-phase ac terminals has recently been utilized in the literature for ac to ac power conversion. Nonetheless, the existing control techniques essentially involve complicated linear controller design with special modulation schemes. This paper presents a simple yet high performance controller based on finite control set model predictive control (FCS-MPC) for ac/dc/ac power conversion using nine-switch topology. FCS-MPC algorithm is designed to control two ac terminals independently by making use of 27 combinations of voltage vectors. The first ac terminal which features an active front end rectifier with unity power factor is connected to power grid, while the second ac terminal is used to control three-phase load. Achievement of multiple control objectives within the same converter topology is made feasible by the use of cost function in FCS-MPC algorithm. Simulation results are presented to verify the functionality of the system.

This paper presents a new control scheme that permits arbitrary power sharing between parallel inverters connected to a microgrid operating in island mode. The scheme processes the active and reactive output power information from all the inverters in a central controller that calculates the set-points for each inverter, based on the desired ratios of their output powers. This necessitates adjustment of the inverters' terminal voltages (phase and magnitude) relative to the voltage at the common ac bus. The power-sharing scheme is validated using MATLAB/Simulink simulation from three three-phase parallel inverters connected to a number of passive loads.

The multi-channel (MC) back-to-back voltage source inverter (VSI)-fed doubly fed induction machine (DFIM) is emerging as a highly interesting topic in large-rated variable speed pumped-storage power plants (PSPP) in view of cost, optimal efficiency, and space requirements. Although the VSI is the fundamental part of the drive controlling the active/reactive power of the plant, redundancy is presently not adopted in practice causing the unit as a whole to shut down upon a failure in the converter and control circuit. This paper evaluates a large-rated (250 MW) DFIM-fed variable-speed unit of a PSPP in terms of its reliability and availability. A Markov model is developed to assess the reliability of the drive based on a number of factors including survivability and annual failure rate (FIT). Further, the Markov model is applied to different PSPPs for comparison of reliability among them.

Chromosomal rearrangements are common in cancer. More than 50% occur in common fragile sites and disrupt tumor suppressors. However, such rearrangements are not known in gastric cancer. Here we report recurrent 18q2 breakpoints in 6 of 17 gastric cancer cell lines. The rearranged chromosome 18, t(9;18), in MKN7 cells was flow sorted and identified by reverse chromosome painting. High-resolution tiling array hybridization mapped breakpoints to DOK6 (docking protein 6) intron 4 in FRA18C (18q22.2) and an intergenic region in 9q22.2. The same rearrangement was detected by FISH in 22% of 99 primary gastric cancers. Intron 4 truncation was associated with reduced DOK6 transcription. Analysis of The Cancer Genome Atlas stomach adenocarcinoma cohort showed significant correlation of DOK6 expression with histological and molecular phenotypes. Multiple oncogenic signaling pathways (gastrin-CREB, NGF-neurotrophin, PDGF, EGFR, ERK, ERBB4, FGFR1, RAS, VEGFR2 and RAF/MAP kinase) known to be active in aggressive gastric cancers were strikingly diminished in gastric cancers with low DOK6 expression. Median survival of patients with low DOK6-expressing tumors was 2100 days compared with 533 days in patients with high DOK6-expressing tumors (log-rank P = 0.0027). The level of DOK6 expression in tumors predicted patient survival independent of TNM stage. These findings point to new functions of human DOK6 as an adaptor that interacts with diverse molecular components of signaling pathways. Our data suggest that DOK6 expression is an integrated biomarker of multiple oncogenic signals in gastric cancer and identify FRA18C as a new cancer-associated fragile site., Gastric cancer: Chromosome rearrangement linked to less aggressive tumors Gastric tumors often harbor a chromosome abnormality that disrupts a key signaling gene, resulting in less aggressive cancers. Oi Lian Kon from the National Cancer Centre Singapore and colleagues searched for chromosomal rearrangements in 17 gastric cancer cell lines. The researchers discovered a recurrent breakpoint in six of the cell lines that mapped to a gene called DOK6, which encodes a protein that provides a docking platform for multiple signaling molecules. They also found the abnormality in 22 of 99 tissue samples taken from gastric cancer patients. This defect led to lower expression of DOK6 and, in turn, less active oncogenic signaling pathways. Patients with low DOK6-expressing gastric cancers lived longer on average than those with high DOK6-expressing tumors. The findings point to DOK6 levels as a potential drug target and diagnostic biomarker.

Conventional pulse-frequency-modulated (PFM) zero-current switching series resonant (SR) inverter-fed voltage-multiplier-based high-voltage dc power supplies have nearly zero switching loss. However, they have limitations of poor controllability at light load and large output voltage ripple at low switching frequencies. To address these problems, this letter proposes a new control scheme that is based on digitally tuning tank capacitance and slightly varying pulse frequency of SR inverter. For the realization of the proposed control approach, the tank circuit of the resonant inverter is made up of several tank capacitors that are switched into or out of the tank circuit by electromechanical switches. By digitally modulating the tank capacitance, the output voltage changes in steps. The regulation of output voltage between two adjacent steps is achieved by slightly varying the pulse frequency. The proposed control scheme has several features, namely, a wide range of output voltage controllability even at light loads, less output voltage ripple, and less current stress on the inverter's power switches at light loads. Therefore, the proposed control approach alleviates most of the problems associated with conventional PFM. Experimental results obtained from a scaled-down laboratory prototype are presented to verify the effectiveness of the proposed system.

This paper deals with controlling a grid-connected dual-active bridge multilevel inverter for renewable energy integration. The concept of direct power control is integrated with model predictive control algorithm, which is termed as predictive direct power control, to control the real and reactive power injected into the power grid. The proposed multilevel inverter allows more options of feasible voltage vectors for switching vector selections in order to generate multilevel outputs, and thereby obtaining high power quality in the power grid. By using the predictive direct power control, simulation results show that the proposed multilevel inverter produces lower power ripple and manage to achieve currents with low total harmonic distortion which are well within the IEEE standard. The modeling and simulation of the system are implemented and validated by MATLAB Simulink software.

This paper presents a three-phase switched-battery multilevel (SBM) inverter for solar photovoltaic (PV) applications. The proposed inverter requires less number of power MOSFETs and gate drivers, and therefore, it is expected to be more compact and reliable than the conventional cascaded H-bridge multilevel (CHBM) inverter. For example, sixty units of power MOSFETs are required to construct a three-phase 11-level CHBM inverter, whilst a SBM inverter with the same number of levels needs only 27 units. The switching losses of the SBM inverter are expected to be lower than that in conventional PWM-controlled inverters because the power MOSFETs in the SBM inverter are switched at a much lower frequency. In addition, the proposed inverter has an integrated charge mode operation which is very suitable for solar PV applications. The performance of an 11-level SBM inverter has been evaluated using PSIM software and the simulation results confirm that the proposed inverter is capable of producing low total harmonic distortion (THD) AC voltages without the need of bulky filters.

This paper presents a new topology based on the series resonant converter (SRC) for high-voltage application. The proposed topology consists of two series resonant tanks. Each series resonant tank is built up by connecting a tank capacitor in series to a high-voltage transformer with the leakage inductance of the high-voltage transformer is absorbed as resonant inductor. Therefore, two high-voltage transformers are used in this topology with their primary windings are connected in series and secondary output are rectified and mixed before supply to load. The series resonant tanks are energized alternately by controlling two IGBT switches with pulse frequency modulation (PFM). This topology is operating in discontinuous conduction mode (DCM) with all IGBT switches are operating in zero current switching (ZCS) condition and hence no switching loss occurs. Moreover, this topology has low conduction loss as it requires only half number of IGBT switches compared to conventional full-bridge inverter based SRC. The effectiveness of the proposed topology is verified by simulation using OrCAD PSpice and the simulation results are presented.

This paper presents a novel topology based on the zero current switching series resonant (ZCS-SR) converter for high-voltage application. The proposed topology consists of two series resonant tanks. Each series resonant tank is built up by connecting a tank capacitor in series to a high-voltage transformer with the leakage inductance of the high-voltage transformer is absorbed as resonant inductor. Therefore, two high-voltage transformers are used in this topology with their primary windings are connected in series. The secondary output of both transformers are boosted by half-wave voltage multiplier and mixed before supply to load. The series resonant tanks are energized alternately by controlling two IGBT switches with pulse frequency modulation (PFM). This topology is operating in discontinuous conduction mode (DCM) with all IGBT switches are operating in zero current switching (ZCS) condition and hence no switching loss occurs. Moreover, this topology has low conduction loss as it requires only half number of IGBT switches compared to conventional full-bridge inverter based SRC. The effectiveness of the proposed topology is verified by simulation using OrCAD PSpice and the simulation results will be presented.

Nine-switch converter has been recently known for its higher compactness with reduced switch count as compared to the back-to-back converter. The readily available dc-link capacitor made it an appropriate alternative for ac/dc/ac conversion in microgrids. Regardless of the complicated Pulse Width Modulation control scheme, this paper proposes a novel predictive power control for the nine-switch converter which is simple and allows concurrent control of real and reactive power flow between two islanded microgrids. The proposed control scheme adopts the virtual flux vectors and a newly defined reactive power to improve the power quality under the existence of grid voltage disturbances, i.e., voltage unbalance and voltage distortion. Simulation results of the proposed predictive power control guarantee decoupled active and reactive power controls, fast response, accurate power and dc-link voltage tracking, and sinusoidal current waveforms with low harmonic distortions under the various grid conditions.

Summary High switching loss remains a predominant issue in conventional finite control set model predictive control (FCS-MPC) for voltage source inverter, aside from the uneven distributed loss between upper switches and lower switches. While maintaining the inherent simplicity and effective reference tracking capability of conventional FCS-MPC, a new FCS-MPC is proposed to acquire substantial improvement in switching loss reduction by choosing the optimal zero vector and two active vectors. Selection of the two active vectors is performed by considering two legs that have maximum and minimum output voltage at particular sampling instant, while the selection of the optimal zero vector is based on the switching states of the previous sampling instant. The proposed method also ensures uniformly distributed loss in each phase as well as between upper switches and lower switches. Further switching loss reduction by selecting the appropriate weighting factor in the cost function is investigated for both the conventional and proposed methods as well. A loss model is constructed in MATLAB/SIMULINK for analyzing quantitative switching loss, conduction loss, total harmonic distortion, and number of switching. The proposed method ensured its superior performance under different load angles and sampling periods, and all the results are verified through simulation.

This paper proposes the adoption of a multilevel dc link converter for a grid connected battery energy storage system in low voltage applications. The multilevel dc link converter is the simple upgrade of a typical two level voltage source converter with the incorporation of some cascaded modular chopper cells which constitute a switched-battery circuit. With the additional chopper cells, more candidates of voltage vectors are available for switching vector selection in power control. Compared to two level voltage source converter using a look-up-table direct power control or finite control set model predictive direct power control, the multilevel dc link converter which employed the latter power control tracks the reference power with much lower power ripple, as well as results in much lower total harmonic distortion in grid current. Therefore, the power quality can be improved significantly. Simulation results are presented to verify that a 3 level dc link converter is more effective than a two level voltage source converter for the grid-connected battery energy storage systems in both generating mode and charging mode.

Gastric cancer remains highly fatal due to a dearth of diagnostic biomarkers for early stage disease and molecular targets for therapy. Plasma membrane proteins, including cluster of differentiation (CD) proteins and receptor tyrosine kinases (RTKs), are a rich reservoir of biomarkers. Recognizing that interrogating plasma membrane proteins individually overlooks extensive interactions among them, we have systematically investigated the membrane proteomes and transcriptomes of six gastric cancer cell lines. Our data revealed aberrantly high expression of proteins whose functions accurately reflect the clinical phenotype of gastric cancer, and prioritized critical RTKs and CD proteins in gastric cancer. Expression of selected surface proteins was confirmed by flow cytometry and immunostaining of clinical gastric cancer tissues. Close to 90% of the gastric cancer tissues in a cohort showed up-regulation of at least one of four proteins, that is, MET, EPHA2, FGFR2, and CD104/ITGB4. All intestinal type gastric cancer tumors in this cohort overexpressed at least one of a panel of three proteins, MET, FGFR2, and EPHA2. This study reports the first quantitative global landscape of the surface proteome of gastric cancer cells and provides a shortlist of gastric cancer biomarkers.

The conventional pulse frequency modulated (PFM) zero current switching (ZCS) series resonant (SR) inverter fed dc high voltage power supplies have nearly zero switching loss. However, they have limitations like narrow variation of output voltage and poor control at light load. To alleviate these limitations, this paper proposes a multi-output ZCS-SR inverter fed high voltage dc-dc converter. The SR-inverter in the proposed system has four outputs that are connected to a single transformer linked load via four resonant capacitors each of which have distinct capacitance. Due to distinct values of resonant capacitors, the impedance of tank circuit and hence the power transformer rate is different for four outputs. Thus all the four inverter outputs are fed to load in parallel when maximum load power is desired and a single output that has highest tank circuit impedance is fed to load when lowest load power is required and vice versa. For the four inverter outputs there are sixteen possible combinations to feed them to load in parallel, thus the load power increase from its lowest value to highest in sixteen steps. Switching frequency is adjusted within in its narrow limits to adjust the voltage between two nearest steps. The proposed system has been simulated using PSPICE software. The obtained results show that proposed system has several advantages such as wide range of output voltage control, low output voltage ripple over the entire range and low current stress at light load.

This paper proposes a multi-output ZCS-SR inverter fed voltage multiplier based high voltage dc-dc converter to achieve wide range of controllability. The SR-inverter in the proposed system has four outputs that are connected to a single transformer linked load via four resonant capacitors each of which have distinct capacitance. Due to distinct values of resonant capacitors, the impedance of tank circuit and hence the power transfer rate is different for four outputs. Thus all the four inverter outputs are fed to load in parallel when maximum load power is desired and a single output that has highest tank circuit impedance is fed to load when lowest load power is required and vice versa. For the four inverter outputs there are sixteen possible combinations to feed them to load in parallel, thus the load power increase from its lowest value to highest in sixteen steps. Switching frequency is adjusted within in its narrow limits to adjust the voltage between two nearest steps. Proposed high voltage converter have several features such as wide range of control, less voltage ripple and low current stress on power switches. The proposed converter is simulated using PSPICE software and results confirm its better performance.

This paper presents the use of a digitally tuned resonant capacitance control with narrow range frequency modulation to regulate the output voltage of a zero current switching series resonant (ZCS-SR) inverter-fed transformer-linked DC-DC converter for X-ray power supply application. In this control scheme, the series resonant inverter consists of several capacitors which are switched into and out of resonant tank circuit by relays. The capacitance of the resonant tank is modulated digitally by controlling the closure of relays which causes the output voltage to increase or decrease in steps. The output voltage in between any two adjacent steps is adjusted by varying the switching frequency in a narrow range. By modulating both resonant tank capacitance and switching frequency, it is able to regulate the output voltage over a wide range. Furthermore, the switching losses of the proposed system are eliminated with all switches operating under soft switching conditions over the entire range of output voltage. Verification of the proposed system is done by computer simulation using Orcad PSPICE.

We integrated LC-MS/MS-based and protein antibody array-based proteomics with genomics approaches to investigate the phosphoproteome and transcriptome of gastric cancer cell lines and endoscopic gastric biopsies from normal subjects and patients with benign gastritis or gastric cancer. More than 3,000 non-redundant phosphorylation sites in over 1,200 proteins were identified in gastric cancer cells. We correlated phosphoproteome data with transcriptome data sets and reported the expression of 41 protein kinases, 5 phosphatases and 65 phosphorylated mitochondrial proteins in gastric cancer cells. Transcriptional expression levels of 190 phosphorylated proteins were >2-fold higher in gastric cancer cells compared to normal stomach tissue. Pathway analysis demonstrated over-presentation of DNA damage response pathway and underscored critical roles of phosphorylated p53 in gastric cancer. This is the first study to comprehensively report the gastric cancer phosphoproteome. Integrative analysis of the phosphoproteome and transcriptome provided an expansive view of molecular signaling pathways in gastric cancer.

Biosafety and efficacy considerations that impede clinical application of gene therapy could be addressed by nonviral ex vivo cell therapy, utilizing transgenic cells that have been comprehensively pre-evaluated for genotoxic potential and transgene expression. We evaluated the genotoxic potential of phiC31 bacteriophage integrase-mediated transgene integration in cord-lining epithelial cells (CLECs) readily cultured from the outer membrane of human umbilical cords, by sequencing and mapping integration sites, spectral karyotyping, high-resolution genome copy number, transcriptome, and transgene copy number analyses and in vivo tumorigenicity. Of 44 independent integration events

In this paper we present the design optimization of an emerging concept, the employment of a microfluidic channel as the heat sink in a thermoelectric generator. This combination shows its superiority particularly when the heat source experiences small temperature changes, rendering the generator unable to enhance its performance and hence imposing a constraint on the generated power. The proposed simulation model, which is composed of 100 pairs of polysilicon thermocouples, is integrated with a rectangular polydimethylsiloxane (PDMS) microchannel heat sink. The choice of the employed coolant is silicone oil. The efforts to predict the optimized performance of the model are based on the lengths of the thermo-elements, channel geometry, coolant flow rate, as well as the temperature difference between the heat source and heat sink. The ultimate simulation results of the optimized thermoelectric generator reveal a voltage efficiency factor as high as 11.752 V cm−2 K−1 and a power efficiency factor as high as 0.2377 μW cm−2 K−2.

In this paper, a novel double series resonant high-voltage dc-dc converter with dual-mode pulse frequency modulation (PFM) control scheme is proposed. The proposed topology consists of two series resonant tanks and hence two resonant currents flow in each switching period. Moreover, it consists of two high-voltage transformer with the leakage inductances are absorbed as resonant inductor in the series resonant tanks. The secondary output of both transformers are rectified and mixed before supplying to load. In the resonant mode operation, the series resonant tanks are energized alternately by controlling two Insulated Gate Bipolar Transistor (IGBT) switches with pulse frequency modulation (PFM). This topology operates in discontinuous conduction mode (DCM) with all IGBT switches operating in zero current switching (ZCS) condition and hence no switching loss occurs. To achieve fast rise in output voltage, a dual-mode PFM control during start-up of the converter is proposed. In this operation, the inverter is started at a high switching frequency and as the output voltage reaches 90% of the target value, the switching frequency is reduced to a value which corresponds to the target output voltage. This can effectively reduce the rise time of the output voltage and prevent overshoot. Experimental results collected from a 100-W laboratory prototype are presented to verify the effectiveness of the proposed system.

Conventional pulse frequency modulated (PFM) zero current switching (ZCS) series resonant (SR) inverter fed high voltage dc power supplies have nearly zero switching loss. However, they have limitations of poor controllability at light loads and large output voltage ripple at low switching frequencies. To address these problems, this paper proposes a combined resonant tank capacitance and pulse frequency modulation based control approach. For the realization of the proposed control approach, the tank circuit of the resonant inverter is made up of several resonant capacitors that are switched into or out of the tank circuit by electromechanical switches. The output voltage of the converter is regulated by digitally modulating the resonant tank capacitance and narrowly varying the switching frequency. The proposed control scheme has several features, namely a wide range of controllability even at light loads, less output voltage ripple, and less current stress on the inverter's power switches at light loads. Therefore, the proposed control approach alleviates most of the problems associated with conventional PFM. Experimental results obtained from a scaled down laboratory prototype are presented to verify the effectiveness of the proposed system.

Aims: Disease-specific chromosomal rearrangements are well known as clinical biomarkers in leukemias, lymphomas and sarcomas, with some being instrumental in the development of targeted therapy. However, few chromosomal rearrangements characteristic of epithelial tumors are known. Recent discoveries in prostate and non-small cell lung cancer suggest that epithelial malignancies may also harbor characteristic rearrangements of pathogenic significance. Thus, we aimed to investigate if recurrent rearrangements occur in gastric cancer. Methods: Seventeen gastric cancer cell lines were surveyed by spectral karyotyping and copy number analysis to identify recurrent breakpoints. Clinical tissue microarrays were probed by fluorescence in situ hybridization (FISH) assays for the most frequent breakpoints. We analyzed flow-sorted rearranged chromosomes using high resolution copy number analysis, deep sequencing and custom tiling array CGH to locate the translocation junctions. Quantitative genomic and RT-PCR, and FISH using fosmid clones further confirmed breakpoint positions. Results: Breakpoints at 18q were the most prevalent among 45 recurrent breakpoints, being present in six of 17 gastric cancer cell lines. 18q12.2 and 18q22.2 breakpoints were present in 44% and 22%, respectively, of 99 primary gastric cancers. These breakpoints were absent in breast, colorectal, hepatocellular, pancreatic and prostate cancers. However, the 18q12.2 breakpoint was present in 47% of lung adenocarcinomas. 18q monosomy was common in intestinal metaplasia. Custom-designed FISH assays further identified translocation partners, t(6;18), t(8;18) and t(9;18) in 4%, 5% and 10%, respectively, of 99 primary gastric cancers. Sharp transitions in genome copy number of flow-sorted translocated chromosomes mapped 18q breakpoints with greater precision, and were confirmed by deep sequencing as well as custom tiling array. The 18q22.2 breakpoint mapped to intron 4 of DOK6. The 18q12.2 breakpoint mapped to an intergenic region, 146kb from an enhancer (element 851, Vista Enhancer browser). Conclusion: This is the first documentation of recurrent chromosomal rearrangements in clinical gastric cancer. Ongoing work is focused on understanding what functional consequences, if any, are associated with these signature translocations. Acknowledgements: We thank Dr. Sun Young Rha (Yonsei Cancer Center, South Korea) for the kind gift of seven gastric cancer cell lines, Dr. Nigel Carter and Ms Bee Ling Ng (Wellcome Trust Sanger Institute, United Kingdom) for chromosome flow sorting, Dr. Steve Rozen and Dr. Ioana Cutcutache (Duke-NUS Medical School, Singapore) for assistance with sequence analysis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3823. doi:10.1158/1538-7445.AM2011-3823