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102. 16 mental health

Author

Doy, R, Blowers, E J, and Sutton, E

Published
2006

106. Protocol for a partially nested randomised controlled trial to evaluate the effectiveness of the scleroderma patient-centered intervention network COVID-19 home-isolation activities together (SPIN-CHAT) program to reduce anxiety among at-risk scleroderma patients

Author

Thombs, BD, Kwakkenbos, L, Carrier, M-E, Bourgeault, A, Tao, L, Harb, S, Gagarine, M, Rice, D, Bustamante, L, Ellis, K, Duchek, D, Wu, Y, Bhandari, PM, Neupane, D, Carboni-Jimenez, A, Henry, RS, Krishnan, A, Sun, Y, Levis, B, He, C, Turner, KA, Benedetti, A, Culos-Reed, N, El-Baalbaki, G, Hebblethwaite, S, Bartlett, SJ, Dyas, L, Patten, S, Varga, J, Fortune, C, Gietzen, A, Guillot, G, Lewis, N, Nielsen, K, Richard, M, Sauve, M, Welling, J, Baron, M, Furst, DE, Gottesman, K, Malcarne, V, Mayes, MD, Mouthon, L, Nielson, WR, Riggs, R, Wigley, F, Assassi, S, Boutron, I, Ells, C, van den Ende, C, Fligelstone, K, Frech, T, Godard, D, Harel, D, Hinchcliff, M, Hudson, M, Johnson, SR, Larche, M, Leite, C, Nguyen, C, Pope, J, Portales, A, Rannou, F, Rodriguez Reyna, TS, Schouffoer, AA, Suarez-Almazor, ME, Agard, C, Albert, A, Andre, M, Arsenault, G, Benzidia, I, Bernstein, EJ, Berthier, S, Bissonnette, L, Boire, G, Bruns, A, Carreira, P, Casadevall, M, Chaigne, B, Chung, L, Cohen, P, Correia, C, Dagenais, P, Denton, C, Domsic, R, Dubois, S, Dunne, J, Dunogue, B, Fare, R, Farge-Bancel, D, Fortin, PR, Gill, A, Gordon, J, Granel-Rey, B, Gyger, G, Hachulla, E, Hatron, P-Y, Herrick, AL, Hij, A, Hoa, S, Ikic, A, Jones, N, Fernandes, AJDB, Kafaja, S, Khalidi, N, Lambert, M, Launay, D, Liang, P, Maillard, H, Maltez, N, Manning, J, Marie, I, Martin, M, Martin, T, Masetto, A, Maurier, F, Mekinian, A, Melchor, S, Nikpour, M, Olagne, L, Poindron, V, Proudman, S, Regent, A, Riviere, S, Robinson, D, Rodriguez, E, Roux, S, Smets, P, Smith, D, Sobanski, V, Spiera, R, Steen, V, Stevens, W, Sutton, E, Terrier, B, Thorne, C, Wilcox, P, Ayala, MC, Ostbo, N, Thombs, BD, Kwakkenbos, L, Carrier, M-E, Bourgeault, A, Tao, L, Harb, S, Gagarine, M, Rice, D, Bustamante, L, Ellis, K, Duchek, D, Wu, Y, Bhandari, PM, Neupane, D, Carboni-Jimenez, A, Henry, RS, Krishnan, A, Sun, Y, Levis, B, He, C, Turner, KA, Benedetti, A, Culos-Reed, N, El-Baalbaki, G, Hebblethwaite, S, Bartlett, SJ, Dyas, L, Patten, S, Varga, J, Fortune, C, Gietzen, A, Guillot, G, Lewis, N, Nielsen, K, Richard, M, Sauve, M, Welling, J, Baron, M, Furst, DE, Gottesman, K, Malcarne, V, Mayes, MD, Mouthon, L, Nielson, WR, Riggs, R, Wigley, F, Assassi, S, Boutron, I, Ells, C, van den Ende, C, Fligelstone, K, Frech, T, Godard, D, Harel, D, Hinchcliff, M, Hudson, M, Johnson, SR, Larche, M, Leite, C, Nguyen, C, Pope, J, Portales, A, Rannou, F, Rodriguez Reyna, TS, Schouffoer, AA, Suarez-Almazor, ME, Agard, C, Albert, A, Andre, M, Arsenault, G, Benzidia, I, Bernstein, EJ, Berthier, S, Bissonnette, L, Boire, G, Bruns, A, Carreira, P, Casadevall, M, Chaigne, B, Chung, L, Cohen, P, Correia, C, Dagenais, P, Denton, C, Domsic, R, Dubois, S, Dunne, J, Dunogue, B, Fare, R, Farge-Bancel, D, Fortin, PR, Gill, A, Gordon, J, Granel-Rey, B, Gyger, G, Hachulla, E, Hatron, P-Y, Herrick, AL, Hij, A, Hoa, S, Ikic, A, Jones, N, Fernandes, AJDB, Kafaja, S, Khalidi, N, Lambert, M, Launay, D, Liang, P, Maillard, H, Maltez, N, Manning, J, Marie, I, Martin, M, Martin, T, Masetto, A, Maurier, F, Mekinian, A, Melchor, S, Nikpour, M, Olagne, L, Poindron, V, Proudman, S, Regent, A, Riviere, S, Robinson, D, Rodriguez, E, Roux, S, Smets, P, Smith, D, Sobanski, V, Spiera, R, Steen, V, Stevens, W, Sutton, E, Terrier, B, Thorne, C, Wilcox, P, Ayala, MC, and Ostbo, N

Abstract

Objective Contagious disease outbreaks and related restrictions can lead to negative psychological outcomes, particularly in vulnerable populations at risk due to pre-existing medical conditions. No randomised controlled trials (RCTs) have tested interventions to reduce mental health consequences of contagious disease outbreaks. The primary objective of the Scleroderma Patient-centered Intervention Network COVID-19 Home-isolation Activities Together (SPIN-CHAT) Trial is to evaluate the effect of a videoconference-based program on symptoms of anxiety. Secondary objectives include evaluating effects on symptoms of depression, stress, loneliness, boredom, physical activity, and social interaction.

Published
2020

107. Changes in mental health symptoms from pre-COVID-19 to COVID-19 among participants with systemic sclerosis from four countries: A Scleroderma Patient-centered Intervention Network (SPIN) Cohort study

Author

Thombs, BD, Kwakkenbos, L, Henry, RS, Carrier, M-E, Patten, S, Harb, S, Bourgeault, A, Tao, L, Bartlett, SJ, Mouthon, L, Varga, J, Benedetti, A, Fortune, C, Gietzen, A, Guillot, G, Lewis, N, Richard, M, Sauve, M, Welling, J, Fligelstone, K, Gottesman, K, Leite, C, Perez, E, Baron, M, Malcarne, V, Mayes, MD, Nielson, WR, Riggs, R, Assassi, S, Ells, C, van den Ende, C, Frech, T, Harel, D, Hinchcliff, M, Hudson, M, Johnson, SR, Larche, M, Nguyen, C, Pope, J, Rannou, F, Reyna, TSR, Schouffoer, AA, Suarez-Almazor, ME, Agard, C, Albert, A, Bernstein, EJ, Berthier, S, Bissonnette, L, Bruns, A, Carreira, P, Chaigne, B, Chung, L, Correia, C, Denton, C, Domsic, R, Dunne, J, Dunogue, B, Farge-Bancel, D, Fortin, PR, Gordon, J, Granel-Rey, B, Hatron, P-Y, Herrick, AL, Hoa, S, Jones, N, Fernandes, AJDB, Kafaja, S, Khalidi, N, Launay, D, Manning, J, Marie, I, Martin, M, Mekinian, A, Melchor, S, Nikpour, M, Olagne, L, Proudman, S, Regent, A, Riviere, S, Robinson, D, Rodriguez, E, Roux, S, Sobanski, V, Steen, V, Sutton, E, Thorne, C, Wilcox, P, Ayala, MC, Carboni-Jimenez, A, Gagarine, M, Nordlund, J, Ostbo, N, Rice, DB, Turner, KA, Culos-Reed, N, Dyas, L, El-Baalbaki, G, Hebblethwaite, S, Bustamante, L, Duchek, D, Ellis, K, Thombs, BD, Kwakkenbos, L, Henry, RS, Carrier, M-E, Patten, S, Harb, S, Bourgeault, A, Tao, L, Bartlett, SJ, Mouthon, L, Varga, J, Benedetti, A, Fortune, C, Gietzen, A, Guillot, G, Lewis, N, Richard, M, Sauve, M, Welling, J, Fligelstone, K, Gottesman, K, Leite, C, Perez, E, Baron, M, Malcarne, V, Mayes, MD, Nielson, WR, Riggs, R, Assassi, S, Ells, C, van den Ende, C, Frech, T, Harel, D, Hinchcliff, M, Hudson, M, Johnson, SR, Larche, M, Nguyen, C, Pope, J, Rannou, F, Reyna, TSR, Schouffoer, AA, Suarez-Almazor, ME, Agard, C, Albert, A, Bernstein, EJ, Berthier, S, Bissonnette, L, Bruns, A, Carreira, P, Chaigne, B, Chung, L, Correia, C, Denton, C, Domsic, R, Dunne, J, Dunogue, B, Farge-Bancel, D, Fortin, PR, Gordon, J, Granel-Rey, B, Hatron, P-Y, Herrick, AL, Hoa, S, Jones, N, Fernandes, AJDB, Kafaja, S, Khalidi, N, Launay, D, Manning, J, Marie, I, Martin, M, Mekinian, A, Melchor, S, Nikpour, M, Olagne, L, Proudman, S, Regent, A, Riviere, S, Robinson, D, Rodriguez, E, Roux, S, Sobanski, V, Steen, V, Sutton, E, Thorne, C, Wilcox, P, Ayala, MC, Carboni-Jimenez, A, Gagarine, M, Nordlund, J, Ostbo, N, Rice, DB, Turner, KA, Culos-Reed, N, Dyas, L, El-Baalbaki, G, Hebblethwaite, S, Bustamante, L, Duchek, D, and Ellis, K

Abstract

INTRODUCTION: No studies have reported mental health symptom comparisons prior to and during COVID-19 in vulnerable medical populations. OBJECTIVE: To compare anxiety and depression symptoms among people with a pre-existing medical condition and factors associated with changes. METHODS: Pre-COVID-19 Scleroderma Patient-centered Intervention Network Cohort data were linked to COVID-19 data from April 2020. Multiple linear and logistic regression were used to assess factors associated with continuous change and ≥ 1 minimal clinically important difference (MCID) change for anxiety (PROMIS Anxiety 4a v1.0; MCID = 4.0) and depression (Patient Health Questionnaire-8; MCID = 3.0) symptoms, controlling for pre-COVID-19 levels. RESULTS: Mean anxiety symptoms increased 4.9 points (95% confidence interval [CI] 4.0 to 5.7). Depression symptom change was negligible (0.3 points; 95% CI -0.7 to 0.2). Compared to France (N = 159), adjusted anxiety symptom change scores were significantly higher in the United Kingdom (N = 50; 3.3 points, 95% CI 0.9 to 5.6), United States (N = 128; 2.5 points, 95% CI 0.7 to 4.2), and Canada (N = 98; 1.9 points, 95% CI 0.1 to 3.8). Odds of ≥1 MCID increase were 2.6 for the United Kingdom (95% CI 1.2 to 5.7) but not significant for the United States (1.6, 95% CI 0.9 to 2.9) or Canada (1.4, 95% CI 0.7 to 2.5). Older age and adequate financial resources were associated with less continuous anxiety increase. Employment and shorter time since diagnosis were associated with lower odds of a ≥ 1 MCID increase. CONCLUSIONS: Anxiety symptoms, but not depression symptoms, increased dramatically during COVID-19 among people with a pre-existing medical condition.

Published
2020

109. Chemistry of the orion molecular cloud core

Author

Sutton, E. C., Peng, R., Danchi, W. C., Jaminet, P. A., Sandell, G., Russell, A. P. G., Araki, H., editor, Brézin, E., editor, Ehlers, J., editor, Frisch, U., editor, Hepp, K., editor, Jaffe, R. L., editor, Kippenhahn, R., editor, Weidenmüller, H. A., editor, Wess, J., editor, Zittartz, J., editor, Beiglböck, W., editor, Winnewisser, Gisbert, editor, and Pelz, Guido C., editor

Published
1995
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110. The ABC of community emergency care: 16 mental health

Author

Doy, R., Blowers, E.J., and Sutton, E.

Subjects
Psychoses -- Diagnosis, Psychoses -- Care and treatment, Violence -- Management, Drug abuse -- Care and treatment, Drug abuse -- Methods, Company business management, Health
Published
2006

111. Mechanisms of anoxia-induced atrial natriuretic peptide release in the isolated rat atria

Author

Skvorak, John P., Sutton, E. Truitt, Rao, Papineni S., and Dietz, John R.

Subjects
Natriuretic peptides -- Physiological aspects, Atriums -- Physiological aspects, Hypoxia -- Physiological aspects, Rats -- Physiological aspects, Biological sciences
Abstract

The factors involved in atrial natriuretic peptide (ANP) response to a physical stimulus, stretch, were investigated in the isolated rat atria. Reduced oxygen tension and anoxic conditions caused a significant increase in ANP secretion, suggesting that they are potent stimuli of ANP release. An endothelin receptor inhibitor, indomethacin, abolished ANP response to anoxia and oxygen tension.

Published
1996

112. Attenuation of arteriolar alpha2-adrenoceptor sensitivity during endotoxemia

Author

Baker, Carleton H., Sutton, E. Truitt, Price, Joel M., Ortiz-Tweed, Maria, and Nessellroth, Susan

Subjects
Epinephrine -- Receptors, Vasoconstrictors -- Physiological aspects, Septic shock -- Analysis, Muscles -- Research, Biological sciences
Abstract

Experimental studies in male Wistar rats using videomicroscopy reveal that endotoxin shock or endotoxemia causes a decrease in adrenergic vasoconstrictor response of the arterioles of cremaster muscle, attenuates the alpha2-adrenergic receptor activity and exerts minimum influence on the activity of alpha1-adrenergic receptors. Endotoxin also attenuates the reduction in arteriolar concentration. A decrease in blood flow and the resultant metabolic disturbances also mediate the decrease in alpha2-sensitivity.

Published
1994

113. Correction to: Echinodermata: The complex immune system in echinoderms (Advances in Comparative Immunology, 10.1007/978-3-319-76768-0_13)

Author

Smith L. C., Arizza V., Hudgell M. A. B., Barone G., Bodnar A. G., Buckley K. M., Cunsolo V., Dheilly N. M., Franchi N., Fugmann S. D., Furukawa R., Garcia-Arraras J., Henson J. H., Hibino T., Irons Z. H., Li C., Lun C. M., Majeske A. J., Oren M., Pagliara P., Pinsino A., Raftos D. A., Rast J. P., Samasa B., Schillaci D., Schrankel C. S., Stabili L., Stensv K., Sutton E., Smith L.C., Arizza V., Hudgell M.A.B., Barone G., Bodnar A.G., Buckley K.M., Cunsolo V., Dheilly N.M., Franchi N., Fugmann S.D., Furukawa R., Garcia-Arraras J., Henson J.H., Hibino T., Irons Z.H., Li C., Lun C.M., Majeske A.J., Oren M., Pagliara P., Pinsino A., Raftos D.A., Rast J.P., Samasa B., Schillaci D., Schrankel C.S., Stabili L., Stensv K., and Sutton E.

Subjects
Asteroidea, Brittle stars, Coelomocytes, Crinoidea, Diseases, Echinoidea, Genomics, Holothuroidea, Immune development, Immune responses, Immuno-toxicology, Larval immune cells, Ophiuroidea, Proteomics, Sea cucumbers, Sea lilies, Sea stars, Sea urchins, Senescence, Settore CHIM/03 - Chimica Generale E Inorganica, Settore BIO/05 - Zoologia, Settore BIO/19 - Microbiologia Generale
Abstract

This chapter was inadvertently published with an incorrect spelling of the author's name as V. Arriza whereas it should be V. Arizza. In addition to this the affiliation of one of the chapter authors Elisse Sutton was published incorrectly and it has now been corrected to read as Department of Biological Sciences, Macquarie University, Sydney, NSW, Australia.

Published
2018

116. Effect of muscle length on the in vitro comparison of femoral arteries before and after endotoxin shock

Author

Zhong Zhou, Price, Joel M., Sutton, E. Truitt, and Baker, Carleton H.

Subjects
Septic shock -- Analysis, Muscles -- Physiological aspects, Femoral artery -- Research, Biological sciences
Abstract

Influence of muscle length is determined by an in vitro comparison of control and endotoxin-treated femoral arteries. Pentobarbital is used to anesthetize rats while infusion of endotoxin occurs for one hour. The contralateral artery displays rings preceding and following exposure to endotoxin. This is employed when phenylephrine is used for length tension and dose-response experiments. Endotoxin rings reveal shorter primary lengths for resting tension despite the constant length of maximum active tension. The post-endotoxin period enhances passive stiffness and active tension.

Published
1993

117. Arteriolar endothelium-dependent vasodilation occurs during endotoxin shock

Author

Baker, Carleton H. and Sutton, E. Truitt

Subjects
Septic shock -- Physiological aspects, Microcirculation -- Physiological aspects, Acetylcholine -- Physiological aspects, Sodium nitroferricyanide -- Physiological aspects, Nitric oxide -- Physiological aspects, Hydroquinone -- Physiological aspects, Endothelium-derived relaxing factors -- Physiological aspects, Biological sciences
Abstract

The effects of endotoxin shock on endothelial structure and the function of large arteries were studied using rat cremaster muscles. Arteriolar endothelia of cremaster muscles showed minimal adverse effects and vasodilation upon adminstration of acetylcholine (ACh). Nitric oxide (NO) antagonist hydroquinone was also observed to partially inhibit ACh postendotoxin and extend the survival of endotoxin-treated rats by blocking effects of inducible NO synthase.

Published
1993

122. Data on biomechanics and elemental maps of dental implant-bone complexes in rats

Author

Danieli C. Rodrigues, K. Kim, Sirine C. Fakra, Sunita P. Ho, Putu Ustriyana, Bo Wang, S. Srirangapatanam, Misun Kang, and Sutton E. Wheelis

Subjects
In situ, Microprobe, Materials science, Dental implant, medicine.medical_treatment, Materials Science, Mechanoadaptation, Bioengineering, lcsh:Computer applications to medicine. Medical informatics, Osseointegration, Spatiotemporal biomechanics, Ultimate tensile strength, medicine, Dental/Oral and Craniofacial Disease, lcsh:Science (General), Multidisciplinary, Rehabilitation, Implant-bone complex, Biomechanics, osseointegration, Compression (physics), Mechanoadaptation functional, Mechanoadaptation, functional osseointegration, Adaptive strain, Musculoskeletal, functional osseointegration, Biomedical Imaging, lcsh:R858-859.7, Implant-bone complex (IBC), Implant, lcsh:Q1-390, Biomedical engineering
Abstract

Implant-bone biomechanics and mechanoadaptation of peri‑implant tissue in space (around and along the length of an implant) and time (3-, 11-, and 24-day following implantation) are important for functional osseointegration of dental implants. Spatiotemporal shifts in biomechanics of implant-bone complex in rat maxillae were correlated with maximum (tensile) and minimum (compressive) principal strain profiles in peri‑implant tissue using a hybrid model; biomechanics in situ paired with digital volume correlation. Spatiotemporal changes in elemental counts and their association with mineral density of the peri‑implant tissue were mapped using electron dispersive X-ray and X-ray fluorescence microprobe techniques. Data provided within are related to biomechanical testing of an implant-bone complex in situ. Data also highlight the power of correlating elemental colocalization with tension and compression regions of the peri‑implant tissues to explain spatiotemporal mechanoadaptation of implant-bone complexes. Further interpretation of data is provided in "Mechanoadaptive Strain and Functional Osseointegration of Dental Implants in Rats [1]."

Published
2020
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123. Shortening patient-reported outcome measures through optimal test assembly: Application to the Social Appearance Anxiety Scale in the Scleroderma Patient-centered Intervention Network Cohort

Author

Harel, D., Mills, S.D., Kwakkenbos, L., Carrier, M.E., Nielsen, K., Portales, A., Bartlett, S.J., Malcarne, V.L., Thombs, B.D., Baron, M., Furst, D.E., Gottesman, K., Mayes, M.D., Mouthon, L., Nielson, W.R., Riggs, R., Sauve, M., Wigley, F., Assassi, S., Boutron, I., Maia, A.C., El-Baalbaki, G., Ells, C., Ende, C. van den, Fligelstone, K., Fortune, C., Frech, T., Godard, D., Hudson, M., Impens, A., Jang, Y., Johnson, S.R., Kennedy, A.T., Korner, A., Larche, M., Leite, C., Marra, C., Pope, J., Reyna, T.S.R., Schouffoer, A.A., Steele, R.J., Suarez-Almazor, M.E., Welling, J., Wong-Rieger, D., Agard, C., Albert, A., Andre, M., Arsenault, G., Benmostefa, N., Benzidia, I., Berthier, S., Bissonnette, L., Boire, G., Bruns, A., Carreira, P., Casadevall, M., Chaigne, B., Chung, L., Cohen, P., Dagenais, P., Denton, C., Domsic, R., Dubois, S., Dunne, J.V., Dunogue, B., Esquinca, A., Fare, R., Farge-Bancel, D., Fortin, P.R., Gill, A., Gordon, J., Granel-Rey, B., Grange, C., Gyger, G., Hachulla, E., Hatron, P.Y., Herrick, A.L., Hij, A., Hinchcliff, M., Ikic, A., Jones, N., Fernandes, A.J.D., Kafaja, S., Khalidi, N., Korman, B., Launay, D., Liang, P., London, J., Luna, D., Maillard, H., Manning, J., Martin, M., Martin, T., Masetto, A., Maurier, F., Mekinian, A., Melchor, S., Nikpour, M., Paule, R., Proudman, S., Regent, A., Riviere, S., Robinson, D., Rodriguez, E., Roux, S., Smets, P., Smith, D., Sobanski, V., Spiera, R., Steen, V., Stevens, W., Sutton, E., Terrier, B., Thorne, C., Varga, J., Wilcox, P., Wilson, M., Cumin, J., Fox, R.S., Gholizadeh, S., Jewett, L.R., Levis, B., Pepin, M.R., Turner, K.A., Lambert, M., and SPIN Investigators

Subjects
Adult, Male, medicine.medical_specialty, systemic sclerosis, Concurrent validity, Anxiety, Fear of negative evaluation, Cohort Studies, Experimental Psychopathology and Treatment, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Cronbach's alpha, medicine, Humans, Patient Reported Outcome Measures, optimal test assembly, 030212 general & internal medicine, Aged, Aged, 80 and over, Scleroderma, Systemic, business.industry, Research, short form, Social anxiety, Reproducibility of Results, generalized partial credit model, General Medicine, Middle Aged, stomatognathic diseases, Cross-Sectional Studies, Convergent validity, patient reported outcome measure, Physical Appearance, Body, Physical therapy, Female, Patient-reported outcome, medicine.symptom, business, 030217 neurology & neurosurgery, Cohort study
Abstract

ObjectivesThe Social Appearance Anxiety Scale (SAAS) is a 16-item measure that assesses social anxiety in situations where appearance is evaluated. The objective was to use optimal test assembly (OTA) methods to develop and validate a short-form SAAS based on objective and reproducible criteria.DesignThis study was a cross-sectional analysis of baseline data from adults enrolled in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort.SettingAdults in the SPIN Cohort in the present study were enrolled at 28 centres in Canada, the USA and the UK.ParticipantsThe SAAS was administered to 926 adults with scleroderma.Primary and secondary measuresThe SAAS, Brief Fear of Negative Evaluation II (BFNE II), Brief Satisfaction with Appearance Scale (Brief-SWAP), Patient Health Questionnaire-8 (PHQ8) and Social Interaction Anxiety Scale-6 (SIAS-6) were collected, as well as demographic characteristics.ResultsOTA methods identified a maximally informative shortened version for each possible form length between 1 and 15 items. The final shortened version was selected based on prespecified criteria for reliability, concurrent validity and statistically equivalent convergent validity with the BFNE II scale. A five-item short version was selected (SAAS-5). The SAAS-5 had a Cronbach’s α of 0.95 and had high concurrent validity with the full-length form (r=0.97). The correlation of the SAAS-5 with the BFNE II was 0.66, which was statistically equivalent to that of the full-length form. Furthermore, the correlation of the SAAS-5 with the two subscales of the Brief-SWAP, and the SIAS-6, were statistically equivalent to that of the full-length form.ConclusionsOTA was an efficient method for shortening the full-length SAAS to create the SAAS-5.

Published
2019

128. Detection of apoptotic and live pre-osteoblast cell line using impedance-based biosensors with variable electrode design

Author

Danieli C. Rodrigues, Sutton E. Wheelis, Dheera Dammanna, Niman H. Alshareef, Manuel Quevedo-Lopez, A. Gabriela Montaño-Figueroa, Brian M. Hedden, and Hana Shaik

Subjects
Materials science, Polymers, Biomedical Engineering, Biophysics, Apoptosis, 02 engineering and technology, Electrolyte, Biosensing Techniques, Xylenes, 01 natural sciences, Capacitance, Flow cytometry, Cell Line, chemistry.chemical_compound, Parylene, Electrochemistry, medicine, Humans, Electrical impedance, Osteoblasts, medicine.diagnostic_test, Cell growth, 010401 analytical chemistry, General Medicine, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, Electrode, 0210 nano-technology, Biosensor, Biotechnology, Biomedical engineering
Abstract

Electrical impedance-based sensing of cell activity has become a powerful analytical tool that allows the monitoring of several relevant biological processes associated with cell evolution and morphology. In these types of biosensors, the electrode design has a direct impact on the sensitivity because it defines the capability of the biosensor to measure small changes in the impedance resulting from cell activities. Herein, impedance-based biosensors arrays with several configurations were successfully developed and used to study the impact of the electrode layout on the dynamics of cultured pre-osteoblast cells. The biosensor design was initially validated by measuring the effect of electrode design on the capacitance of a dielectric polymer (parylene) that mimics the dielectric characteristics of cell populations, results are shown in the Supplementary information section . Results from in vitro cell growth indicate that the optimized design of single electrodes with a diameter of 50 µm, are the most sensitive to cell motion whereas increasing the number of electrodes allows clear differentiation between living and dead cells after 3 h of inducing apoptosis. Apoptosis death was induced with Staurosporine, a chemical mediator of apoptosis in osteoblasts. These impedance results have been validated with optical imaging and flow cytometry analysis that were performed on parallel cultures. Frequency and electrolyte concentration effects are also discussed.

Published
2018

129. Effects of titanium oxide surface properties on bone-forming and soft tissue-forming cells

Author

Sutton E. Wheelis, A.G. Montaño-Figueroa, Danieli C. Rodrigues, and Manuel Quevedo-Lopez

Subjects
Surface Properties, medicine.medical_treatment, Oxide, Gingiva, 02 engineering and technology, In Vitro Techniques, Microscopy, Atomic Force, Spectrum Analysis, Raman, 03 medical and health sciences, Crystallinity, chemistry.chemical_compound, Mice, 0302 clinical medicine, In vivo, Osteogenesis, medicine, Animals, Humans, Viability assay, Dental implant, General Dentistry, Cells, Cultured, Cell Proliferation, Dental Implants, Titanium, Osteoblasts, Anodizing, 030206 dentistry, Fibroblasts, 021001 nanoscience & nanotechnology, Titanium oxide, chemistry, Biophysics, Microscopy, Electron, Scanning, Alkaline phosphatase, Oral Surgery, 0210 nano-technology
Abstract

Background Previous studies have concluded that certain titanium oxide (TiO2 ) surface properties promote bone-forming cell attachment. However, no comprehensive studies have investigated the effects of TiO2 surface and film morphology on hard and soft tissues. Purpose The aim of this study is to understand the effects of TiO2 morphology on the proliferation and differentiation of murine preosteoblasts (MC3T3-E1) and proliferation of human gingival fibroblasts (HGF-1) using in vitro experiments. Materials and methods Samples were fabricated with several TiO2 thickness and crystalline structure to mimic various dental implant surfaces. in vitro analysis was performed for 1, 3, and 7 days on these samples to assess the viability of MC3T3-E1 and HGF-1 cells in contact with the modified oxide surfaces. Results Results showed that HGF-1 cells exhibited no significant difference in viability on modified oxide surfaces versus a titanium control across experiments. MC3T3-E1 cells exhibited a significantly higher viability for the modified oxide surface in 1 day experiments, but not in 3 or 7 day experiments. Alkaline phosphatase expression in MC3T3-E1 was not significantly different on modified oxide surfaces versus the control across all experiments. A slight positive trend in viability was observed for cells in contact with rougher modified oxide surfaces versus a titanium control in both cell types. Conclusions These observations suggest that crystallinity and thickness do not affect the long-term viability of hard or soft tissue cells when compared to a cpTi surface. Therefore, treatments like anodization on implant components may not directly affect the attachment of hard or soft tissue cells in vivo.

Published
2018

130. Mammalian target of rapamycin is activated in the kidneys of patients with scleroderma renal crisis

Author

Salituri, Jessica, primary, Patey, Natalie, additional, Takano, Tomoko, additional, Fiset, Pierre, additional, Del Rincon, Sonia, additional, Berkson, Laeora, additional, Baron, Murray, additional, Hudson, Marie, additional, Baron, M., additional, Hudson, M., additional, Gyger, G., additional, Pope, J., additional, Larché, M., additional, Khalidi, N., additional, Masetto, A., additional, Sutton, E., additional, Robinson, D., additional, Rodriguez-Reyna, T.S., additional, Smith, D., additional, Thorne, C., additional, Fortin, P.R., additional, and Fritzler, M., additional

Published
2019
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137. What have multicentre registries across the world taught us about the disease features of systemic sclerosis?

Author

Proudman S. M., Huq M., Stevens W., Wilson M. E., Sahhar J., Baron M., Hudson M., Pope J., Allanore Y., Distler O., Kowal-Bielecka O., Matucci-Cerinic M., H. L. Low A., Teng G. G., Law W. G., Santosa A., Nikpour M., Hill C., Lester S., Nash P., Ngian G. -S., Proudman S., Rischmueller M., Roddy J., Strickland G., Thakkar V., Walker J., Zochling J., Markland J., Robinson D., Jones N., Khalidi N., Docherty P., Kaminska E., Masetto A., Sutton E., Mathieu J. -P., Ligier S., Grodzicky T., LeClercq S., Thorne C., Gyger G., Smith D., Fortin P. R., Larche M., Abu-Hakima M., Rodriguez-Reyna T. S., Cabral A. R., Fritzler M., Avouac J., Walker U. A., Guiducci S., Riemekasten G., Air P., Hachulla E., Valentini G., Carreira P. E., Cozzi F., Gurman A. B., Braun-Moscovici Y., Damjanov N., Ananieva L. P., Scorza R., Jimenez S., Busquets J., Li M., Muller-Ladner U., Maurer B., Tyndall A., Lapadula G., Iannone F., Becvar R., Sierakowsky S., Cutolo M., Sulli A., Cuomo G., Vettori S., Rednic S., Nicoara I., Vlachoyiannopoulos P., Montecucco C., Caporali R., Novak S., Czirjak L., Varju C., Chizzolini C., Kucharz E. J., Kotulska A., Kopec-Medrek M., Widuchowska M., Rozman B., Mallia C., Coleiro B., Gabrielli A., Farge D., Hij A., Hesselstrand R., Scheja A., Wollheim F., Martinovic D., Govoni M., Lo Monaco A., Hunzelmann N., Pellerito R., Bambara L. M., Caramaschi P., Black C., Denton C., Henes J., Santamaria V. O., Heitmann S., Krasowska D., Seidel M., Oleszowsky M., Burkhardt H., Himsel A., Salvador M. J., Stamenkovic B., Stankovic A., Tikly M., Starovoytova M. N., Engelhart M., Strauss G., Nielsen H., Damgaard K., Szucs G., Mendoza A. Z., de la Puente Buijdos C., Giraldo W. A. S., Midtvedt O., Garen T., Launay D., Valesini G., Riccieri V., Ionescu R. M., Opris D., Groseanu L., Wigley F. M., Mihai C. M., Cornateanu R. S., Ionitescu R., Gherghe A. M., Gorga M., Dobrota R., Bojinca M., Schett G., Distler J. H., Meroni P., Zeni S., Mouthon L., De Keyser F., Smith V., Cantatore F. P., Corrado A., Ullman S., Iversen L., Pozzi M. R., Eyerich K., Hein R., Knott E., Szechinski J., Wiland P., Szmyrka-Kaczmarek M., Sokolik R., Morgiel E., Krummel-Lorenz B., Saar P., Aringer M., Gunther C., Anic B., Baresic M., Mayer M., Radominski S. C., de Souza Muller C., Azevedo V. F., Agachi S., Groppa L., Chiaburu L., Russu E., Zenone T., Stebbings S., Highton J., Stamp L., Chapman P., O'Donnell J., Solanki K., Doube A., Veale D., O'Rourke M., Loyo E., Rosato E., Pisarri S., Tanaseanu C. -M., Popescu M., Dumitrascu A., Tiglea I., Chirieac R., Ancuta C., Furst D. E., Kafaja S., Garcia de la Pena Lefebvre P., Rubio S. R., Exposito M. V., Sibilia J., Chatelus E., Gottenberg J. E., Chifflot H., Litinsky I., Venalis A., Butrimiene I., Venalis P., Rugiene R., Karpec D., Kerzberg E., Montoya F., Cosentino V., Low A. H. L., Teng G., Chan G., Lim A. Y. N., Ng S. C., Proudman, S. M., Huq, M., Stevens, W., Wilson, M. E., Sahhar, J., Baron, M., Hudson, M., Pope, J., Allanore, Y., Distler, O., Kowal-Bielecka, O., Matucci-Cerinic, M., H. L. Low, A., Teng, G. G., Law, W. G., Santosa, A., Nikpour, M., Hill, C., Lester, S., Nash, P., Ngian, G. -S., Proudman, S., Rischmueller, M., Roddy, J., Strickland, G., Thakkar, V., Walker, J., Zochling, J., Markland, J., Robinson, D., Jones, N., Khalidi, N., Docherty, P., Kaminska, E., Masetto, A., Sutton, E., Mathieu, J. -P., Ligier, S., Grodzicky, T., Leclercq, S., Thorne, C., Gyger, G., Smith, D., Fortin, P. R., Larche, M., Abu-Hakima, M., Rodriguez-Reyna, T. S., Cabral, A. R., Fritzler, M., Avouac, J., Walker, U. A., Guiducci, S., Riemekasten, G., Air, P., Hachulla, E., Valentini, G., Carreira, P. E., Cozzi, F., Gurman, A. B., Braun-Moscovici, Y., Damjanov, N., Ananieva, L. P., Scorza, R., Jimenez, S., Busquets, J., Li, M., Muller-Ladner, U., Maurer, B., Tyndall, A., Lapadula, G., Iannone, F., Becvar, R., Sierakowsky, S., Cutolo, M., Sulli, A., Cuomo, G., Vettori, S., Rednic, S., Nicoara, I., Vlachoyiannopoulos, P., Montecucco, C., Caporali, R., Novak, S., Czirjak, L., Varju, C., Chizzolini, C., Kucharz, E. J., Kotulska, A., Kopec-Medrek, M., Widuchowska, M., Rozman, B., Mallia, C., Coleiro, B., Gabrielli, A., Farge, D., Hij, A., Hesselstrand, R., Scheja, A., Wollheim, F., Martinovic, D., Govoni, M., Lo Monaco, A., Hunzelmann, N., Pellerito, R., Bambara, L. M., Caramaschi, P., Black, C., Denton, C., Henes, J., Santamaria, V. O., Heitmann, S., Krasowska, D., Seidel, M., Oleszowsky, M., Burkhardt, H., Himsel, A., Salvador, M. J., Stamenkovic, B., Stankovic, A., Tikly, M., Starovoytova, M. N., Engelhart, M., Strauss, G., Nielsen, H., Damgaard, K., Szucs, G., Mendoza, A. Z., de la Puente Buijdos, C., Giraldo, W. A. S., Midtvedt, O., Garen, T., Launay, D., Valesini, G., Riccieri, V., Ionescu, R. M., Opris, D., Groseanu, L., Wigley, F. M., Mihai, C. M., Cornateanu, R. S., Ionitescu, R., Gherghe, A. M., Gorga, M., Dobrota, R., Bojinca, M., Schett, G., Distler, J. H., Meroni, P., Zeni, S., Mouthon, L., De Keyser, F., Smith, V., Cantatore, F. P., Corrado, A., Ullman, S., Iversen, L., Pozzi, M. R., Eyerich, K., Hein, R., Knott, E., Szechinski, J., Wiland, P., Szmyrka-Kaczmarek, M., Sokolik, R., Morgiel, E., Krummel-Lorenz, B., Saar, P., Aringer, M., Gunther, C., Anic, B., Baresic, M., Mayer, M., Radominski, S. C., de Souza Muller, C., Azevedo, V. F., Agachi, S., Groppa, L., Chiaburu, L., Russu, E., Zenone, T., Stebbings, S., Highton, J., Stamp, L., Chapman, P., O'Donnell, J., Solanki, K., Doube, A., Veale, D., O'Rourke, M., Loyo, E., Rosato, E., Pisarri, S., Tanaseanu, C. -M., Popescu, M., Dumitrascu, A., Tiglea, I., Chirieac, R., Ancuta, C., Furst, D. E., Kafaja, S., Garcia de la Pena Lefebvre, P., Rubio, S. R., Exposito, M. V., Sibilia, J., Chatelus, E., Gottenberg, J. E., Chifflot, H., Litinsky, I., Venalis, A., Butrimiene, I., Venalis, P., Rugiene, R., Karpec, D., Kerzberg, E., Montoya, F., Cosentino, V., Low, A. H. L., Teng, G., Chan, G., Lim, A. Y. N., and Ng, S. C.

Subjects
0301 basic medicine, medicine.medical_specialty, Pediatrics, Survival, Immunology, Disease, Scleroderma, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Internal medicine, Immunology and Allergy, Medicine, Multicentre registrie, 030203 arthritis & rheumatology, Clinical features, Cohort study, Multicentre registries, Systemic sclerosis, business.industry, Interstitial lung disease, Autoantibody, Clinical features, medicine.disease, 030104 developmental biology, Clinical feature, Cohort, business, Cohort study, Rheumatism
Abstract

Introduction The aim of this study is to compare the clinical features, mortality and causes of death of systemic sclerosis (SSc) patients in four large multicentre registries. Methods Patients seen at least once in the Australian Scleroderma Cohort Study (ASCS) (n = 1714), the Canadian Scleroderma Research Group (CSRG) (n = 1628), the European League Against Rheumatism Scleroderma Trials and Research (EUSTAR) Network (n = 13,996) and the Systemic Sclerosis Cohort in Singapore (SCORE) (n = 500) before August 2016 were included. Clinical manifestations and survival in cohorts and disease subtypes were compared. Results Among 17,838 SSc patients, most were female (86.1%), Caucasian (84.6%) and had the limited cutaneous subtype (lcSSc) (65.0%). The anti-centromere autoantibody was the most prevalent (37.6%). More patients in SCORE had the diffuse subtype (dcSSc) (49.3%) and Scl-70 autoantibody (38.8%) (pConclusions This meta-cohort of SSc patients, the largest reported to date, provides insights into the impact of race and sex on disease manifestations and survival and confirms the early mortality in this disease.

Published
2017
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138. QUEER.ARCHIVE.WORK 2: 1923 INTERNET ARCHIVE EDITION

Author

Paul Soulellis, Barbette, Michael Field, Katherine Harris Bradley, Edith Emma Cooper, Romaine Brooks, Julián Martínez, Jean Toomer, Elsa Gidlow, Hart Crane, Gaston Lachaise, W. E. B. Du Bois, Awa Tsireh, Emma Goldman, Sutton E. Griggs, Alla Nazimova, Nancy Elizabeth Prophet, Paul Soulellis, Barbette, Michael Field, Katherine Harris Bradley, Edith Emma Cooper, Romaine Brooks, Julián Martínez, Jean Toomer, Elsa Gidlow, Hart Crane, Gaston Lachaise, W. E. B. Du Bois, Awa Tsireh, Emma Goldman, Sutton E. Griggs, Alla Nazimova, and Nancy Elizabeth Prophet

Abstract

QUEER.ARCHIVE.WORK 2 (1923 INTERNET ARCHIVE EDITION) was installed in a special reading room at the Internet Archive in San Francisco on January 25, 2019. Printed as an edition of 100, the publication is a newsprint catalogue enclosing a set of annotated risograph prints, allowing lesser-known material from 1923 to intermingle in a loose assemblage. Artifacts include rare, historical LGBTQ content that has been digitized for the first time, and works by African American and Native American artists and writers. All items were originally published in 1923 and are in the public domain as of January 1, 2019. QUEER.ARCHIVE.WORK 2 was ..., https://www.librarystack.org/queer-archive-work-2-1923-internet-archive-edition/?ref=unknown

Published
2019

139. Generation of a Core Set of Items to Develop Classification Criteria for Scleroderma Renal Crisis Using Consensus Methodology

Author

Butler, E-A, Baron, M, Fogo, AB, Frech, T, Ghossein, C, Hachulla, E, Hoa, S, Johnson, SR, Khanna, D, Mouthon, L, Nikpour, M, Proudman, S, Steen, V, Stern, E, Varga, J, Denton, C, Hudson, M, Barnado, A, Bernstein, EJ, Boin, F, Braun-Moscovici, Y, Castelino, FV, Catoggio, LJ, Matucci-Cerinic, M, Chung, L, Clements, P, Csuka, ME, De langhe, E, Distler, J, Distler, O, Farge, DC, Fischer, A, Gabrielli, A, Hasegawa, M, Hayat, S, Herrick, A, Hesselstrand, R, Hsu, V, Hughes, M, Hunzelmann, N, Hummers, L, Iannone, F, Ingegnoli, F, Jacobsen, S, Kawaguchi, Y, Koenig, M, Kuwana, M, Lenaerts, J, Martin, T, Mayes, MD, McMahan, Z, Medsger, T, Merkel, P, Narain, S, Ong, V, Pauling, JD, Pope, J, de la Puente, C, Rischmueller, M, Sofia Rodriguez-Reyna, T, Sahhar, J, Saketkoo, LA, Senecal, J-L, Shah, A, Shah, AA, Alberto Sifuentes-Giraldo, W, Silver, R, Stevens, W, Sutton, E, Thakkar, V, Valentini, G, de Vries-Bouwstra, J, Vonk, M, Walker, UA, Butler, E-A, Baron, M, Fogo, AB, Frech, T, Ghossein, C, Hachulla, E, Hoa, S, Johnson, SR, Khanna, D, Mouthon, L, Nikpour, M, Proudman, S, Steen, V, Stern, E, Varga, J, Denton, C, Hudson, M, Barnado, A, Bernstein, EJ, Boin, F, Braun-Moscovici, Y, Castelino, FV, Catoggio, LJ, Matucci-Cerinic, M, Chung, L, Clements, P, Csuka, ME, De langhe, E, Distler, J, Distler, O, Farge, DC, Fischer, A, Gabrielli, A, Hasegawa, M, Hayat, S, Herrick, A, Hesselstrand, R, Hsu, V, Hughes, M, Hunzelmann, N, Hummers, L, Iannone, F, Ingegnoli, F, Jacobsen, S, Kawaguchi, Y, Koenig, M, Kuwana, M, Lenaerts, J, Martin, T, Mayes, MD, McMahan, Z, Medsger, T, Merkel, P, Narain, S, Ong, V, Pauling, JD, Pope, J, de la Puente, C, Rischmueller, M, Sofia Rodriguez-Reyna, T, Sahhar, J, Saketkoo, LA, Senecal, J-L, Shah, A, Shah, AA, Alberto Sifuentes-Giraldo, W, Silver, R, Stevens, W, Sutton, E, Thakkar, V, Valentini, G, de Vries-Bouwstra, J, Vonk, M, and Walker, UA

Abstract

OBJECTIVE: To generate a core set of items to develop classification criteria for scleroderma renal crisis (SRC) using consensus methodology. METHODS: An international, multidisciplinary panel of experts was invited to participate in a 3-round Delphi exercise developed using a survey based on items identified by a scoping review. In round 1, participants were asked to identify omissions and clarify ambiguities regarding the items in the survey. In round 2, participants were asked to rate the validity and feasibility of the items using Likert-type scales ranging from 1 to 9 (where 1 = very invalid/unfeasible, 5 = uncertain, and 9 = very valid/feasible). In round 3, participants reviewed the results and comments from round 2 and were asked to provide final ratings. Items rated as highly valid and feasible (median scores ≥7 for each) in round 3 were selected as the provisional core set of items. A consensus meeting using a nominal group technique was conducted to further reduce the core set of items. RESULTS: Ninety-nine experts from 16 countries participated in the Delphi exercise. Of the 31 items in the survey, consensus was achieved on 13, in the categories hypertension, renal insufficiency, proteinuria, and hemolysis. Eleven experts took part in the nominal group technique discussion, where consensus was achieved in 5 domains: blood pressure, acute kidney injury, microangiopathic hemolytic anemia, target organ dysfunction, and renal histopathology. CONCLUSION: A core set of items that characterize SRC was identified using consensus methodology. This core set will be used in future data-driven phases of this project to develop classification criteria for SRC.

Published
2019

140. Development and validation of the Scleroderma Clinical Trials Consortium Damage Index (SCTC-DI): a novel instrument to quantify organ damage in systemic sclerosis

Author

Ferdowsi, N, Huq, M, Stevens, W, Hudson, M, Wang, M, Tay, T, Burchell, JL, Mancuso, S, Rabusa, C, Sundararajan, V, Prior, D, Proudman, SM, Baron, M, Nikpour, M, Frech, T, Proudman, S, Chatterjee, S, Chung, L, Gordon, JK, Haemel, A, Johnson, SR, Khanna, D, Medsger, TA, Merkel, P, Pauling, J, Pope, JE, Rodriguez-Reyna, T, Saketkoo, L, Seibold, JR, Shah, A, Steen, V, Strickland, G, Ngian, G-S, Rischmueller, M, Roddy, J, Sahhar, J, Walker, J, Youssef, P, Pope, J, Markland, J, Robinson, D, Jones, N, Khalidi, N, Docherty, P, Kaminska, E, Masetto, A, Sutton, E, Mathieu, J-P, Ligier, S, Grodzicky, T, LeClercq, S, Thorne, C, Gyger, G, Smith, D, Fortin, PR, Larche, M, Abu-Hakima, M, Rodriguez-Reyna, TS, Cabral, AR, Fritzler, M, Ferdowsi, N, Huq, M, Stevens, W, Hudson, M, Wang, M, Tay, T, Burchell, JL, Mancuso, S, Rabusa, C, Sundararajan, V, Prior, D, Proudman, SM, Baron, M, Nikpour, M, Frech, T, Proudman, S, Chatterjee, S, Chung, L, Gordon, JK, Haemel, A, Johnson, SR, Khanna, D, Medsger, TA, Merkel, P, Pauling, J, Pope, JE, Rodriguez-Reyna, T, Saketkoo, L, Seibold, JR, Shah, A, Steen, V, Strickland, G, Ngian, G-S, Rischmueller, M, Roddy, J, Sahhar, J, Walker, J, Youssef, P, Pope, J, Markland, J, Robinson, D, Jones, N, Khalidi, N, Docherty, P, Kaminska, E, Masetto, A, Sutton, E, Mathieu, J-P, Ligier, S, Grodzicky, T, LeClercq, S, Thorne, C, Gyger, G, Smith, D, Fortin, PR, Larche, M, Abu-Hakima, M, Rodriguez-Reyna, TS, Cabral, AR, and Fritzler, M

Abstract

OBJECTIVE: We sought to develop the first Damage Index (DI) in systemic sclerosis (SSc). METHODS: The conceptual definition of 'damage' in SSc was determined through consensus by a working group of the Scleroderma Clinical Trials Consortium (SCTC). Systematic literature review and consultation with patient partners and non-rheumatologist experts produced a list of potential items for inclusion in the DI. These steps were used to reduce the items: (1) Expert members of the SCTC (n=331) were invited to rate the appropriateness of each item for inclusion, using a web-based survey. Items with >60% consensus were retained; (2) Using a prospectively acquired Australian cohort data set of 1568 patients, the univariable relationships between the remaining items and the endpoints of mortality and morbidity (Physical Component Summary score of the Short Form 36) were analysed, and items with p<0.10 were retained; (3) using multivariable regression analysis, coefficients were used to determine a weighted score for each item. The DI was externally validated in a Canadian cohort. RESULTS: Ninety-three (28.1%) complete survey responses were analysed; 58 of 83 items were retained. The univariable relationships with death and/or morbidity endpoints were statistically significant for 22 items, with one additional item forced into the multivariable model by experts due to clinical importance, to create a 23-item weighted SCTC DI (SCTC-DI). The SCTC-DI was predictive of morbidity and mortality in the external cohort. CONCLUSIONS: Through the combined use of consensus and data-driven methods, a 23-item SCTC-DI was developed and retrospectively validated.

Published
2019

141. The Hindered Hand

Author

Sutton E. Griggs, John Cullen Gruesser, Hanna Wallinger, Sutton E. Griggs, John Cullen Gruesser, and Hanna Wallinger

Subjects
African Americans--Fiction, Race relations--Fiction
Abstract

Between 1899 and 1908, five long works of fiction by the Nashville-based black Baptist minister Sutton E. Griggs appeared in print, making him the most prolific African American novelist at the turn of the twentieth century. Brought out by Griggs's own Orion Publishing Company in three distinct printings in 1905 and 1906, The Hindered Hand; or, the Reign of the Repressionist addresses the author's key themes of amalgamation, emigration, armed resistance, and US overseas expansion; includes a melodramatic love story; and features two of the most sensational scenes in early African American fiction—a harrowingly graphic lynching of an innocent black couple based on actual events and the elaboration of a plot to wipe out white Southerners by introducing yellow fever germs into the water supply. Written in response to Thomas Dixon's recently published race-baiting novel The Leopard's Spots, Griggs's book depicts the remnants of the old Southern planter class, the racial crisis threatening the South and the North, the social ferment of the time, the changing roles of women, and the thwarted aspirations of a trio of African American veterans following the war against Spain. This scholarly edition of the novel, providing newly discovered biographical information and copious historical context, makes a significant contribution to African American literary scholarship.

Published
2017

142. Surface characterization of titanium implant healing abutments before and after placement

Author

Thomas Wilson, Sutton E. Wheelis, Danieli C. Rodrigues, and Pilar Valderrama

Subjects
Male, Anatase, Materials science, Scanning electron microscope, Surface Properties, chemistry.chemical_element, Dental Abutments, 02 engineering and technology, Spectrum Analysis, Raman, Corrosion, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Materials Testing, Humans, General Dentistry, Aged, Dental Implants, Titanium, Microscopy, Anodizing, Photoelectron Spectroscopy, 030206 dentistry, Middle Aged, 021001 nanoscience & nanotechnology, Titanium oxide, chemistry, Titanium dioxide, Microscopy, Electron, Scanning, Female, Implant, Oral Surgery, 0210 nano-technology, Biomedical engineering
Abstract

Background Implant healing abutments (IHA) have a vital role in soft tissue healing after implant placement. Although there is thorough investigation on the implant surface, little is known about the effects potentially damaging oral conditions impose on healing abutments. Purpose To characterize the surface of titanium healing abutments before and after clinical placement to understand the effects of the oral environment and time on the device surface. Materials and methods Ten regular Straumann IHA were subjected to characterization pre and postplacement to elucidate the effects of the oral environment on device surfaces. Changes in surface crystallinity, morphology, and elemental composition were monitored with Raman spectroscopy, scanning electron microscopy, optical microscopy, and x-ray photoelectron spectroscopy, respectively. In addition, corrosion rate and polarization resistance were obtained to assess electrochemical device stability after placement. Results Control analysis indicated the titanium oxide of IHAs was thicker than natural commercially pure titanium and had the structure of crystalline anatase. After removal, the abutments possessed large amounts of biological debris, visible scratches, and discoloration sparsely on the surface. Spectroscopic analysis revealed the titanium oxide on the surface of IHAs was structurally unchanged, with crystalline titanium dioxide still present on the surface. Electrochemical results revealed that implanted healing abutments possessed a significantly higher corrosion rate than controls (change in corrosion rate = 2.34 ± 0.58 nm/year). Conclusions Healing abutments were stable in the oral environment due to the chemical stability of the oxide, and were likely subjected to abrasions from unintentional loading and oral hygiene techniques.

Published
2017

143. Submillimeter line observations of the proto-planetary nebula CRL 2688

Author

Jaminet, P. A, Danchi, W. C, Sandell, Goran, and Sutton, E. C

Subjects
Astrophysics
Abstract

The protoplanetary nebula CRL 2688 with 14-arcsec resolution was observed, and the envelope in CO, (C-13)O, CS, and H(C-13)N was mapped. The submillimeter lines show strong emission from two components of the envelope: a cold, dense, optically thick slow wind and a warm, optically thin fast wind. In the maps, the slow wind appears compact and circularly symmetric. A mass-loss rate in the fast wind of 0.00002 solar mass/yr is estimated, if the wind was continuous. The C-12/C-13 ratio in the fast wind is 5, compared to about 20 in the slow wind. The value in the HCN/CO abundance ratio may be lower in the fast wind than in the slow wind. It is argued that the velocity gradients are not caused by rotation, but rather by asymmetries in the envelope associated with the fast wind.

Published
1992
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144. Molecular line survey of Sagittarius B2(M) from 330 to 355 GHz and comparison with Sagittarius B2(N)

Author

Sutton, E. C, Jaminet, P. A, Danchi, W. C, and Blake, Geoffrey A

Subjects
Astrophysics
Abstract

A submillimeter survey of Sgr B2 is described in which sufficient spatial resolution permitted the observation of some of the source structure. The position Sgr B2(M) is examined in relation to the submillimeter emission of Sgr B2(N) and previous millimeter observational data of source (M) at a lower spatial resolution. Because the submillimeter observations are more sensitive to core emission, the molecules SO2 and CH3OH tend to dominate the spectrum. The core emission is found to be similar to that of the Orion molecular cloud, and the submillimeter and millimeter lines have high optical depths. The (N) source has a much higher column density than that of (M) except for SO and SO2, and (N) also appears to have a higher excitation which can indicate a core with a higher density.

Published
1991
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