Search

Your search keyword '"Suter, Melissa A."' showing total 812 results
Start Over Author "Suter, Melissa A."
812 results on '"Suter, Melissa A."'

103. Optical Microscopy of the Pediatric Vocal Fold

Author

Boudoux, Caroline, Leuin, Shelby C., Oh, Wang Yuhl, Suter, Melissa J., Desjardins, Adrien E., Vakoc, Benjamin J., Bouma, Brett E., Hartnick, Christopher J., and Tearney, Guillermo J.

Published
2009

104. Maternal Metabolic Biomarkers are Associated with Obesity and Excess Gestational Weight Gain.

Author

Antony, Kathleen M., Romezi, Mona, Lindgren, Kourtnee, Mitchell, Kristen B., Venable, Susan F., Racusin, Diana A., Suter, Melissa A., and Aagaard, Kjersti M.

Subjects
BIOMARKERS, WEIGHT gain in pregnancy, INTERLEUKINS, KRUSKAL-Wallis Test, ANALYSIS of variance, LEPTIN, GLUCAGON-like peptide 1, PREGNANT women, BLOOD collection, GHRELIN, INSULIN, TUMOR necrosis factors, BODY mass index, OBESITY in women, INFLAMMATORY mediators, STATISTICAL correlation, C-peptide, PEPTIDES, METABOLITES
Abstract

Objective  The purpose of this study was to evaluate the independent contribution of maternal obesity and gestational weight gain (GWG) in excess of the Institute of Medicine's guidelines on levels of maternal serum inflammatory and metabolic measures. Study Design  Banked maternal serum samples from 120 subjects with documented prepregnancy or first trimester body mass index (BMI) were utilized for analyte analyses. Validated, BMI-specific formulas were utilized to categorize GWG as either insufficient, at goal or excess based on the Institute of Medicine guidelines with gestational age adjustments. Serum was analyzed for known inflammatory or metabolic pathway intermediates using the Luminex xMap system with the MILLIPLEX Human Metabolic Hormone Magnetic Bead Panel. Measured analytes included interleukin-6, monocyte chemoattractant protein-1, and tumor necrosis factor-α and metabolic markers amylin, c-peptide, ghrelin, gastric inhibitory polypeptide, glucagon-like peptide-1, glucagon, insulin, leptin, pancreatic polypeptide, and peptide YY. Kruskal–Wallis ANOVA and Pearson's correlation coefficients were calculated for each marker. Results  C-peptide, insulin, and leptin all varied significantly with both obesity and GWG while glucagon-like peptide-1 varied by BMI but not GWG. These analytes covaried with other metabolic analytes, but not with inflammatory analytes. Conclusion  Maternal metabolic biomarkers at delivery vary significantly with both obesity and GWG. Taken together, these findings suggest that GWG (with and without comorbid obesity) is an important mediator of measurable metabolites in pregnancy but is not necessarily accompanied by inflammatory measures in serum. These findings are consistent with GWG being an independent risk factor for metabolic disturbances during pregnancy. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

108. Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB)

Author

Suter, Melissa A., primary, Aagaard, Kjersti M., additional, Coarfa, Cristian, additional, Robertson, Matthew, additional, Zhou, Guodong, additional, Jackson, Brian P., additional, Thompson, Dominique, additional, Putluri, Vasanta, additional, Putluri, Nagireddy, additional, Hagan, Joseph, additional, Wang, Lihua, additional, Jiang, Weiwu, additional, Lingappan, Krithika, additional, and Moorthy, Bhagavatula, additional

Published
2019
Full Text
View/download PDF

109. Quantitative assessment of airway remodelling and response to allergen in asthma

Author

Adams, David C., primary, Miller, Alyssa J., additional, Applegate, Matthew B., additional, Cho, Josalyn L., additional, Hamilos, Daniel L., additional, Chee, Alex, additional, Holz, Jasmin A., additional, Szabari, Margit V., additional, Hariri, Lida P., additional, Harris, R. Scott, additional, Griffith, Jason W., additional, Luster, Andrew D., additional, Medoff, Benjamin D., additional, and Suter, Melissa J., additional

Published
2019
Full Text
View/download PDF

129. In vivo optical imaging for low-risk microscopic diagnosis of IPF

Author

Hariri, Lida, primary, Muniappan, Ashok, additional, Keyes, Colleen, additional, Wain, John, additional, Lanuti, Michael, additional, Morse, Christopher, additional, Gaissert, Henning, additional, Auchincloss, Hugh, additional, Adams, David, additional, Szabari, Margit, additional, Sharma, Amita, additional, Colby, Thomas, additional, Mino-Kenudson, Mari, additional, Mark, Eugene, additional, Kradin, Richard, additional, Pahlevaninezhad, Hamid, additional, Goulart, Hannah, additional, Liang, Lloyd, additional, Tager, Andrew, additional, and Suter, Melissa, additional

Published
2018
Full Text
View/download PDF

132. Reply to Wijmans et al.: Optical Coherence Tomography: A Valuable Novel Tool for Assessing the Alveolar Compartment in Interstitial Lung Disease?

Author

Hariri, Lida P., primary, Adams, David C., additional, Wain, John C., additional, Lanuti, Michael, additional, Muniappan, Ashok, additional, Sharma, Amita, additional, Colby, Thomas V., additional, Mino-Kenudson, Mari, additional, Mark, Eugene J., additional, Kradin, Richard L., additional, Goulart, Hannah, additional, and Suter, Melissa J., additional

Published
2018
Full Text
View/download PDF

133. Endobronchial Optical Coherence Tomography for Low-Risk Microscopic Assessment and Diagnosis of Idiopathic Pulmonary Fibrosis In Vivo

Author

Hariri, Lida P., primary, Adams, David C., additional, Wain, John C., additional, Lanuti, Michael, additional, Muniappan, Ashok, additional, Sharma, Amita, additional, Colby, Thomas V., additional, Mino-Kenudson, Mari, additional, Mark, Eugene J., additional, Kradin, Richard L., additional, Goulart, Hannah, additional, Tager, Andrew M., additional, and Suter, Melissa J., additional

Published
2018
Full Text
View/download PDF

135. Experimental Zika Virus Infection in the Pregnant Common Marmoset Induces Spontaneous Fetal Loss and Neurodevelopmental Abnormalities

Author

Seferovic, Maxim, primary, Martín, Claudia Sánchez-San, additional, Tardif, Suzette D., additional, Rutherford, Julienne, additional, Castro, Eumenia C.C., additional, Li, Tony, additional, Hodara, Vida L., additional, Parodi, Laura M., additional, Giavedoni, Luis, additional, Layne-Colon, Donna, additional, Tamhankar, Manasi, additional, Yagi, Shigeo, additional, Martyn, Calla, additional, Reyes, Kevin, additional, Suter, Melissa, additional, Aagaard, Kjersti M., additional, Chiu, Charles Y., additional, and Patterson, Jean L., additional

Published
2018
Full Text
View/download PDF

136. 871: Primary Placental Trophoblasts from Primate Species are Permissive for Zika Virus (ZIKV) Replication

Author

Seferovic, Maxim D., primary, San Martin, Claudia Sanchez, additional, Tamhankar, Manasi, additional, Li, Tony, additional, Hu, Min, additional, Blackman, Marcia, additional, Martyn, Calla, additional, Sunshine, Sara, additional, Suter, Melissa, additional, Tardif, Suzette, additional, Chiu, Charles, additional, Patterson, Jean, additional, and Aagaard, Kjersti, additional

Published
2018
Full Text
View/download PDF

140. 270: Commensal microbes confer protection against Zika virus infection in a murine gnotobiotic model of congenital Zika syndrome

Author

Seferovic, Maxim D., primary, Valentine, Gregory, additional, Meyer, Kristen, additional, Harnish, J Michael, additional, Suter, Melissa, additional, Prince, Amanda, additional, Gorchakov, Rodion, additional, Berry, Rebecca, additional, Fowler, Stephanie, additional, Swennes, Alton, additional, Murray, Kristy, additional, and Aagaard, Kjersti, additional

Published
2018
Full Text
View/download PDF

144. In vivo optical coherence tomography: the role of the pathologist

Author

Hariri, Lida P., Mino-Kenudson, Mari, Mark, Eugene J., and Suter, Melissa J.

Subjects
Medical errors, Tomography, Health
Abstract

Optical coherence tomography (OCT) is a nondestructive, high-resolution imaging modality, providing cross-sectional, architectural images at near histologic resolutions, with penetration depths up to a few millimeters. Optical frequency domain imaging is a second-generation OCT technology that has equally high resolution with significantly increased image acquisition speeds and allows for large area, high-resolution tissue assessments. These features make OCT and optical frequency domain imaging ideal imaging techniques for surface and endoscopic imaging, specifically when tissue is unsafe to obtain and/ or suffers from biopsy sampling error. This review focuses on the clinical impact of OCT in coronary, esophageal, and pulmonary imaging and the role of the pathologist in interpreting high-resolution OCT images as a complement to standard tissue pathology. (Arch Pathol Lab Med. 2012; 136:1492-1501; doi: 10.5858/arpa.2012-0252-SA), OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL FREQUENCY DOMAIN IMAGING Optical coherence tomography (OCT) is a nondestructive, high-resolution imaging modality that generates cross-sectional images with endogenous contrast based on mismatches in index [...]

Published
2012
Full Text
View/download PDF

145. Family Physicians’ Perceived Prevalence, Safety, and Screening for Cigarettes, Marijuana, and Electronic-Nicotine Delivery Systems (ENDS) Use during Pregnancy

Author

Northrup, Thomas F., primary, Klawans, Michelle R., additional, Villarreal, Yolanda R., additional, Abramovici, Adi, additional, Suter, Melissa A., additional, Mastrobattista, Joan M., additional, Moreno, Carlos A., additional, Aagaard, Kjersti M., additional, and Stotts, Angela L., additional

Published
2017
Full Text
View/download PDF

147. Alterations in Expression of Imprinted Genes from the H19/IGF2 Loci in a Multigenerational Model of IUGR

Author

Gonzalez-Rodriguez, Pablo, Cantu, Jessica, O’Neil, Derek, Seferovic, Maxim, Goodspeed, Danielle M., Suter, Melissa A., and Aagaard, Kjersti M.

Subjects
Metabolic Syndrome, CCCTC-Binding Factor, Chromatin Immunoprecipitation, Fetal Growth Retardation, Gene Expression Regulation, Developmental, DNA Methylation, female genital diseases and pregnancy complications, Article, Epigenesis, Genetic, Up-Regulation, Rats, Sprague-Dawley, Repressor Proteins, Genomic Imprinting, Insulin-Like Growth Factor II, Pregnancy, Prenatal Exposure Delayed Effects, embryonic structures, Dietary Supplements, Models, Animal, Animals, Female, RNA, Long Noncoding, sense organs, skin and connective tissue diseases, Promoter Regions, Genetic
Abstract

The H19/IGF2 imprinted loci have attracted recent attention because of their role in cellular differentiation and proliferation, heritable gene regulation, and in utero or early postnatal growth and development. Expression from the imprinted H19/IGF2 locus involves a complex interplay of 3 means of epigenetic regulation: proper establishment of DNA methylation, promoter occupancy of CTCF, and expression of microRNA-675. We have demonstrated previously in a multigenerational rat model of intrauterine growth restriction the epigenetic heritability of adult metabolic syndrome in a F2 generation. We have further demonstrated abrogation of the F2 adult metabolic syndrome phenotype with essential nutrient supplementation of intermediates along the 1-carbon pathway and shown that alterations in the metabolome precede the adult onset of metabolic syndrome. The upstream molecular and epigenomic mediators underlying these observations, however, have yet to be elucidated fully.In the current study, we sought to characterize the impact of the intrauterine growth-restricted lineage and essential nutrient supplementation on both levels and molecular mediators of H19 and IGF2 gene expression in the F2 generation.F2 intrauterine growth-restricted and sham lineages were obtained by exposing P1 (grandmaternal) pregnant dams to bilateral uterine artery ligation or sham surgery at gestational day 19.5. F1 pups were allocated to the essential nutrient supplemented or control diet at postnatal day 21, and bred at 6-7 weeks of age. Hepatic tissues from the resultant F2 offspring at birth and at weaning (day 21) were obtained. Bisulfite modification and sequencing was employed for methylation analysis. H19 and IGF2 expression was measured by quantitative polymerase chain reaction. Promoter occupancy was quantified by the use of chromatin immunoprecipitation, or ChIP, against CTCF insulator proteins.Growth-restricted F2 on control diet demonstrated significant down-regulation in H19 expression compared with sham lineage (0.7831 vs 1.287; P.05); however, essential nutrient supplementation diet abrogates this difference (4.995 vs 5.100; P.05). Conversely, Igf2 was up-regulated by essential nutrient supplemented diet on the sham lineage (2.0 fold, P = .01), an effect that was not observed in the growth restricted offspring. A significant differential methylation was observed in the promoter region of region H19 among the intrauterine growth-restricted lineage (18% vs 25%; P.05) on a control diet, whereas the essential nutrient supplemented diet was alternately associated with hypermethylation in both lineages (sham: 50%; intrauterine growth restriction: 84%, P.05). Consistent with essential nutrient supplementation impacting the epigenome, a decrease of CTCF promoter occupancy was observed in CTCF4 of the growth restricted lineage (2.45% vs 0.56%; P.05) on the control diet, an effect that was repressed with essential nutrient supplementation.Heritable growth restriction is associated with changes in H19 gene expression; these changes are reversible with diet supplementation to favorably impact adult metabolic syndrome.

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results