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Out-of-time-order correlators (OTOC) in the Ising Floquet system, that can be both integrable and nonintegrable is studied. Instead of localized spin observables, we study contiguous symmetric blocks of spins or random operators localized on these blocks as observables. We find only power-law growth of OTOC in both integrable and nonintegrable regimes. In the non-integrable regime, beyond the scrambling time, there is an exponential saturation of the OTOC to values consistent with random matrix theory. This motivates the use of "pre-scrambled" random block operators as observables. A pure exponential saturation of OTOC in both integrable and nonintegrable system is observed, without a scrambling phase. Averaging over random observables from the Gaussian unitary ensemble, the OTOC is found to be exactly same as the operator entanglement entropy, whose exponential saturation has been observed in previous studies of such spin-chains., 13 pages, 6 figures

Maize is the principal food crop of rain-fed hilly areas of Jammu and Kashmir grown during Kharif season. It is staple food of the tribal population as well as fodder for their animals residing in hilly region of the state. Quality Protein Maize cultivars are nutritionally enriched maize with high protein content (more than 9%) and high level of two essential amino acids lysine (4.07% of protein) and tryptophan (1.05% of protein) content with better balanced amino acid composition in grains. In the FLDs, the average grain yield of Vivek QPM - 9 was observed as 27.40 q/ha where as in case of HQPM - 4 the average yield was 26.10 q/ha in comparison to the check cultivar i.e., Bio Seed 9621 (26.30 q/ha) under rainfed conditions of Rajouri district of J&K. The single cross hybrid seed production of QPM showed that the farmer’s income enhancement was about 2.78 times than the grain crop. The B: C ratio of grain yield was 1.72 whereas it was observed 2.78 in case of seed yield.

Liraglutide, a daily injectable glucagon-like peptide-1 receptor (GLP-1r) agonist, has been shown to reduce liver fat content (LFC) in humans. Data regarding the effect of dulaglutide, a once-weekly GLP-1r agonist, on human LFC are scarce. This study examined the effect of dulaglutide on LFC in individuals with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).Effect of dulaglutide on liver fat (D-LIFT) was a 24 week, open-label, parallel-group, randomised controlled trial to determine the effect of dulaglutide on liver fat at a tertiary care centre in India. Adults (n = 64), who had type 2 diabetes and MRI-derived proton density fat fraction-assessed LFC of ≥6.0% at baseline, were randomly assigned to receive dulaglutide weekly for 24 weeks (add-on to usual care) or usual care, based on a predefined computer-generated number with a 1:1 allocation that was concealed using serially numbered, opaque, sealed envelopes. The primary endpoint was the difference of the change in LFC from 0 (baseline) to 24 weeks between groups. The secondary outcome measures included the difference of the change in pancreatic fat content (PFC), change in liver stiffness measurement (LSM in kPa) measured by vibration-controlled transient elastography, and change in liver enzymes.Eighty-eight patients were screened; 32 were randomly assigned to the dulaglutide group and 32 to the control group. Overall, 52 participants were included for per-protocol analysis: those who had MRI-PDFF data at baseline and week 24. Dulaglutide treatment resulted in a control-corrected absolute change in LFC of -3.5% (95% CI -6.6, -0.4; p = 0.025) and relative change of -26.4% (-44.2, -8.6; p = 0.004), corresponding to a 2.6-fold greater reduction. Dulaglutide-treated participants also showed a significant reduction in γ-glutamyl transpeptidase (GGT) levels (mean between-group difference -13.1 U/l [95% CI -24.4, -1.8]; p = 0.025) and non-significant reductions in aspartate aminotransferase (AST) (-9.3 U/l [-19.5, 1.0]; p = 0.075) and alanine aminotransferase (ALT) levels (-13.1 U/l [-24.4, 2.5]; p = 0.10). Absolute changes in PFC (-1.4% [-3.2, 0.3]; p = 0.106) and LSM (-1.31 kPa [-2.99, 0.37]; p = 0.123) were not significant when comparing the two groups. There were no serious drug-related adverse events.When included in the standard treatment for type 2 diabetes, dulaglutide significantly reduces LFC and improves GGT levels in participants with NAFLD. There were non-significant reductions in PFC, liver stiffness, serum AST and serum ALT levels. Dulaglutide could be considered for the early treatment of NAFLD in patients with type 2 diabetes.ClinicalTrials.gov NCT03590626 FUNDING: The current study was supported by an investigator-initiated study grant from Medanta-The Medicity's departmental research fund and a grant from the Endocrine and Diabetes Foundation (EDF), India. Graphical abstract.

A centralized airflow control scheme for a complex ocean energy network (OEN) is proposed in this paper to reduce the output power variation (OPV). The OEN is an integrated network of multiple oscillating water columns (OWCs) that are located at different geographical sites connected to a common electrical grid. The complexity of the OWC-OEN increases manifolds due to the integration of several OWCs and design of controllers become very challenging task. So, the centralized airflow control scheme is designed in two stages. In control stage-1, a proportional-integral- (PI-) type controller is designed to provide a common reference command to control stage-2. In control stage-2, the antiwindup PID controllers are implemented for the airflow control of all the OWCs simultaneously. In order to tune the large number of control parameters of this complex system, a fitness function based on integral squared error (ISE) is minimized using the widely adopted particle swarm optimization (PSO) technique. Next, the simulation results were obtained with random wave profiles created using the Joint North Sea Wave Project (JONSWAP) irregular wave model. The OPV of the proposed OWC-OEN was reduced significantly as compared to the individual OWC. It was further observed that the OPV of the proposed scheme was lower than that achieved with uncontrolled and MPPT controlled OWC-OEN. The effect of communication delay on the OPV of the proposed OWC-OEN scheme was also investigated with the proposed controller, which was found to be robust for a delay up to 100 ms. This work was supported in part by the Basque Government through project IT1207-19 and MCIU/MINECO through RTI2018-094902-B-C21/RTI2018-094902-B-C22 (MCIU/AEI/FEDER, UE).

Reinwardtia indica belongs to Linaceae family and used as a folk medicine in Asian countries. Traditionally, it has been used in the treatment of paralysis and anti-microbial in wound healing, etc. The current study was undertaken in order to investigate the antioxidant and memory protective effect of the alcoholic (99.90%) (AERI) and hydro-alcoholic (70:30) leaves extract (HAERI) of Reinwardtia indica, against scopolamine-induced memory impairment in animals and also tried to determine the possible mechanism of action. In addition, phytochemical profiling of alcoholic leaves extract was also conducted through gas chromatography-mass spectrometry (GC-MS/MS). Rats were pretreated with AERI, HAERI (dose 250 and 500 mg/kg) and Donepezil (standard drug) along with scopolamine (1 mg/kg) for a period of 14 days followed by different test like elevated plus maze, passive avoidance, and Morris water maze to assess learning and memory ability. Acetylcholine levels, acetylcholinesterase (AChE), antioxidant enzymes (SOD, CAT & GSH), histopathology of the brain and biochemical test were also performed at the end of the treatment period. The scopolamine treatment resulted in learning and memory deficits which were partially and significantly ameliorated by the AERI at higher dose among other doses of extracts. The AERI at higher dose also counteracted the scopolamine-induced decrease in acetylcholine levels, increase in AChE activity, and decrease in antioxidant enzymes activities. No significant changes observed in the biochemical estimation of all dose of extracts. Histology of brain tissue showed the marked cellular changes in only scopolamine treated group while the standard, AERI and HAERI treated group were showing less damage at hippocampus region of the brain. The phytochemicals found after chemical profiling through GC-MS also supported the activity because of the presence of chemicals already reported for the neuroprotective, memory-enhancing and antioxidant activity, etc. The results demonstrated that the ability of the AERI at higher dose among all doses of extracts has more potential to revert the scopolamine-induced learning and memory deficits in rats by attenuating the decreased level of acetylcholine and antioxidant enzymes.

Purpose: This systematic review has been undertaken to highlight the unforgettable contributions of Prof. Branemark Per-Ingvar (PI). It could be understood that reviewing his work would give an idea of growth of this treatment modality. Materials and Methods: An electronic search on the PubMed/Medline, Ebscohost, and Cochrane database was done using search term “Branemark PI” to identify his publications. Articles published in English and only related to implants and osseointegration were included. Screening of the titles and abstracts were done according to inclusion criteria and suitable studies were included in the review. Results: The initial literature search resulted in 187 articles, out of which 92 articles were excluded due to not meeting the inclusion criteria and 16 articles excluded due to non-availability of even abstract also. A total of 79 articles were finally included in this review. Conclusion: Branemark PI had a great vision of future; who considered edentulism as equal to amputation and came up with the concept of osseointegrated implants to overcome them. The innovations of Branemark had assured the world that it is very much possible to provide implant-supported prosthesis in any situations for the rehabilitation of the individuals.

Hepatocellular carcinoma (HCC) is the sixth most common type of cancer in the world. It is the third leading cause of cancer-related mortality. In more than 80% of people liver cancer-related death is due to its poor prognosis. The flavonoids obtained from natural sources have potent therapeutic effects on HCC. The flavonoid rich methanolic fraction obtained from ethyl acetate extract of leaf of Cestrum nocturnum (MFLCN) was analyzed by UPLC-QTOFMS/MS for the presence of different flavonoids. The physiochemical and pharmacokinetics properties of the identified flavonoids were performed by absorption, distribution, metabolism, excretion, and toxicity (ADMET). It was selected on the basis of Lipinski rule and hepatotoxicity evaluations. The potential gene dataset of HCC were taken from gene card database and targets compounds were selected from target net prediction. Gene ontology and pathway enrichment analysis of HCC was performed via enricher and David web tools. Cytoscape was used to visualize targets and network pathways. MFLCN contains 33 flavonoids. Among these flavonoids, apigenin was selected as principal active compound on the basis of their pharmacokinetic and ADMET properties. Apigenin has 92 targets out of 627 total targets related to HCC, while there was13 pathways in the target-pathway network. Results revealed that apigenin regulates cell proliferation and survival, primarily through different signaling pathways like estrogen, VEGF, PI3K/AKT1, TNF, FoXO, and Ras signaling pathways. Thus, integrating network pharmacology prediction with m-RNA and human protein atlas validation could be an effective method for understanding the molecular mechanism of apigenin on HCC.

At different timings, assessment and comparison of the dimensional stability and surface hardness of three interocclusal recording materials (IRM).Samples of polyvinyl siloxane, ZOE, and bite registration wax were made using stainless steel die. Each group had 10 samples. At 1, 8, 24, and 48 h, the samples were estimated using a 10× amplification stereo microscope.Four readings were taken for each sample, the mean was considered to scale the dimensional change and surface hardness. At 1, 8, 24, and 48 h mean dimensional change was viewed as the most extreme among group 3 followed by group 2 and afterward group 1 (Polyvinyl siloxane was the steadiest, most precise, and had the most noteworthy surface hardness among the three interocclusal materials.

The present study has been carried out with the seed extracts of Nyctanthes arbor-tristis L. (Parijat) and evaluates its antioxidant potential and profiling the phytochemical constituents by Gas Chromatography-Mass Spectrometry (GC-MS) analysis. The antioxidant potential of the seed extracts was measured by four different in vitro assay like 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, superoxide anion free radical scavenging activity, ferric reducing antioxidant power (FRAP) and lipid peroxidation inhibition potential (LPIP) assay. The total phenol content (TPC) and total flavonoid content (TFC) were estimated. The ethyl acetate extract (EAE) of seeds showed potential DPPH free radical scavenging activity (EC50 129.49±3.55µg/ml), superoxide anion radical (EC50 969.94±8.03µg/ml) and LPIP (EC50 452.43±5.07 µg/ml) activities. The total phenol content was maximum in aqueous extract (AQE) which was 201.00±0.20 µg/mg gallic acid equivalent. The EAE was rich with total flavonoid and it was found to be 34.50±0.40 µg/mg rutin equivalent. The EAE was subjected for phytochemical-profiling using GC-MS system. The presence of different phytoconstituents supports the medicinal value of the seeds. The results suggest that EAE constitutes a promising new source of novel compounds. Further, it can be used for isolation and purification of specific compounds which have good antioxidant activities and possess useful biological activities.

We study characteristic, dynamic, and saturation regimes of the out-of-time-order correlation (OTOC) in the constant field Floquet system with and without longitudinal field. In the calculation of OTOC, we take local spins in longitudinal and transverse directions as observables which are local and non-local in terms of Jordan-Wigner fermions, respectively. We use the exact analytical solution of OTOC for the integrable model (without longitudinal field term) with transverse direction spins as observables and numerical solutions for other integrable and nonintegrable cases. OTOCs generated in both cases depart from unity at a kick equal to the separation between the observables when the local spins in the transverse direction and one additional kick is required when the local spins in the longitudinal direction. The number of kicks required to depart from unity depends on the separation between the observables and is independent of the Floquet period and system size. In the dynamic region, OTOCs show power-law growth in both models, the integrable (without longitudinal field) as well as the nonintegrable (with longitudinal field). The exponent of the power-law increases with increasing separation between the observables. Near the saturation region, OTOCs grow linearly with a very small rate., Comment: 12 pages, 7 figures

Objective: Brain drug delivery for effective treatment of neurodegenerative disorders is limited due to the selective permeability of blood brain barrier (BBB). During the past few years, developme...

Nyctanthes arbor-tristis L. is an important member of family Oleaceae. An efficient shoot proliferation response (21.53±0.58 shoots/explant) from cotyledonary node was achieved on Murashige and Skoog (MS) medium supplemented with 22.19 µM 6-benzyl amino purine (BAP). To optimize the role of ammonium and nitrate on shoot proliferation, the explants were cultured on modified MS media (MS-1 to MS-12). Among these media, MS-3 and MS-9 were found most suitable for shoot-proliferation than others. The microshoots after indole 3-butyric acid (IBA) pulse treatment (1968.11 µM) for 30 min, when sub-cultured on ½ strength MS basal medium were successfully rooted with a maximum frequency of root induction (77.66±1.45), the maximum number of roots/ shoot (10.66±0.88) and maximum root length (1.60±0.05 cm). In-vitro rooted plants were acclimatized and transplanted outside into field with 80 percent survival-rate after 90 days. The genetic-fidelity was confirmed by monomorphic nature of inter-simple sequence repeat (ISSR) marker pattern. The ethanol extract of leaves of regenerated plants contained good amount of phenol (118.00±0.82 µg/mg gallic acid equivalent) and flavonoid (17.34±0.64 µg/mg rutin equivalent) and possess strong antioxidant activity. The EC50 value for 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical, superoxide radical (SOD) scavenging activity and lipid peroxidation (LPO) inhibition activity was 339.98±3.27, 755.80±75.50 and 689.67±2.46 µg/ml respectively. Hence, these findings suggest that regenerated plants can be used as a therapeutic and inhibitory agent against free radical-induced disease progression.

The UPLC-Q-TOF–MS/MS analysis of ethanol extract of leaf confirmed the presence of important flavonoids like rutin (RT 5.95), hesperidin (RT 5.99), quercitrin (RT 6.33) and kaempferol-3-O-glucoside (RT 6.82). Photo-induced green synthesis of silver nanoparticles was reported in Nycanthes arbor-tristis. Nanoparticles were efficiently synthesized after mixing of 1% ethanol leaf extract and 1 mM silver nitrate solution under 10 min light exposure at room temperature. The UV–Vis spectrum of the brown colored reaction mixture showed sharp surface plasmon resonance at 460 nm. It confirmed the biosynthesis of silver nanoparticles. Nanoparticles were characterized by using SEM, TEM, and EDX. The results suggest that synthesized nanoparticles lie in the range of 10–50 nm. XRD, SAED and AFM data confirmed the polycrystalline nature of biosynthesized nanoparticles. Silver nanoparticles exhibited strong antibacterial activity than extract. All bacterial clinical isolates were sensitive to nanoparticles. Methicilin resistant Staphylococcus aureus was most susceptible than other isolates. The silver nanoparticles also exhibited good free radical scavenging activity (EC50 670.67 ± 15.70 µg/ml).

This paper presents a Laboratory Virtual Instrument Engineering Workbench (LabVIEW) and Internet of Things (IoT)-based eHealth monitoring system called LI-Care to facilitate the diagnosis of the health condition cost-effectively. The system measures the heart rate, body temperature, blood pressure, oxygen level, and breathing rate, and provides an electrocardiogram (ECG). The required sensors are integrated on a web-based application that keeps track of the essential parameters and gives an alarm indication if one or more physiological parameters go beyond the safe level. It also employs a webcam to obtain the patient view at any time. LabVIEW enables the effortless interfacing of various biomedical sensors with the computer and provides high-speed data acquisition and interactive visualizations. It also provides a web publishing tool to access the interactive window remotely through a web browser. The web-based application is accessible to doctors who are experts in that particular field. They can obtain the real-time reading and directly perform a diagnosis. The parameters measured by the proposed system were validated using the traditional measurement systems, and the Root Mean Square (RMS) errors were obtained for the various parameters. The maximum RMS error as a percentage was 0.159%, which was found in the temperature measurement, and its power consumption is 1 Watt/h. The other RMS errors were 0.05% in measurement of systolic pressure, 0.029% in measurement of diastolic pressure, 0.059% in measurement of breathing rate, 0.002% in measurement of heart rate, 0.076% in measurement of oxygen level, and 0.015% in measurement of ECG. The low RMS errors and ease of deployment make it an attractive alternative for traditional monitoring systems. The proposed system has potential applications in hospitals, nursing homes, remote monitoring of the elderly, non-contact monitoring, etc.

PURPOSE To evaluate studies with a minimum follow-up of 3 years to find the peri-implant marginal bone loss (MBL) and rate of implant failure with platform-switching (PS) and platform-matching (PM) implant-abutment connections. MATERIALS AND METHODS A systematic review and meta-analysis was done based on the preferred reporting items for systematic reviews and meta-analyses guidelines, with a focused question on population, intervention, comparison, and outcome. The Cochrane Collaboration's Risk of Bias tool was used to assess bias. Randomized controlled trials (RCTs) comparing peri-implant MBL and implant failure in patients receiving PS implants and PM implants only were included. The risk ratio (RR) of the implant-abutment connection and implant failure was calculated, and peri-implant MBL was expressed in mean differences (MD) at 95% confidence intervals (CIs). RESULTS Three hundred eighty-one articles were obtained after an initial literature search. Finally, nine articles were included in the study that fulfilled the inclusion criteria. Four hundred twenty-six PS and 411 PM implants were placed with 16 implant failures (8 PS and 8 PM). The implant survival rate was 98.12% for the PS group, and 98.05% for the PM group, with no statistically significant difference (P = .97). The mean peri-implant MBL with the PS implant was lower (0.33 ± 0.41 mm) compared with the PM implant (0.66 ± 0.42 mm). A significant effect of PS implants was found in reducing peri-implant MBL (MD: -0.70, 95% CI: -1.25,-0.15; P = .01) compared with PM implants. The MD of peri-implant MBL between the PS and PM implants decreases with increased follow-up: MD of 0.69 (P = .15) with follow-up of ≥ 3 years but < 5 years, and MD of 0.62 (P = .04) with follow-up of ≥ 5 years. CONCLUSION Reduced peri-implant MBL was found with the PS concept. The peri-implant MBL decreases with an increased mismatch between the abutment and implant platform. The difference in peri-implant MBL in PS and PM implants in the maxilla was greater and favored the PS concept. Bone-level implants with single crowns or splinted prostheses better preserved the peri-implant marginal bone with the PS concept.

This paper aims at modelling of a twin rotor multi-input-multi-output (MIMO) system (TRMS) using fractional-order transfer function with time-delay. The modelling problem, defined as an optimization task, has been solved using a popular Nelder-Mead algorithm, also known as simplex search algorithm, which is one of the best algorithms for multi-dimensional unconstrained optimization without derivatives. The algorithm has been applied using the inbuilt “fminsearch” function in the MATLAB® software package. Further, FOMCON toolbox of MATLAB® has been employed to incorporate the effectiveness of the fractional-order derivative operators in characterizing the system behavior. Experimental simulation depicts that the proposed fractional-order with time delay model of the TRMS is resulting in significant improvement in the system representation with reduced error as compared to the conventional integer-order model with higher number of model parameters.

As the demand for electric vehicles (EVs) is increasing nowadays, the need for customer-friendly, effective, and innovative solutions for charging is rapidly enhancing. The recent advancements in this direction not only include the fast and efficient charging mechanism but also the automation in the process. Frequent plugging in the EV’s charging cable to the socket maybe tiresome that can be overcome by robotic technology, where this repeated task can be done using autonomous mobile robots. This paper deals with a fully automated system of charging EVs via robots with V2X communication. Further, a supercapacitor-based fast and efficient charging method has been proposed, which can be adopted for the autonomous charging process to improve its effectiveness.

Background and aims Acute onset diabetes and diabetic ketoacidosis (DKA) can be precipitated by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in individuals with no history of diabetes. However, data regarding the follow-up of these individuals are scarce. Methods Three patients (data of two patients already published) with acute onset diabetes and DKA, precipitated by coronavirus disease 2019 (COVID-19), were followed for 14 weeks to assess the behavior of the diabetes. Detailed history, anthropometry, laboratory investigations, imaging studies, clinical course and outcomes were documented. Results Three individuals developed symptoms suggestive of SARS CoV-2 infection. After a few days, they were detected to have COVID-19 pneumonia, based on reverse transcription-polymerase chain reaction (RT-PCR) assay and chest imaging. In the meantime, they also developed acute onset diabetes and DKA, which were precipitated by COVID-19. They responded well to treatment, including intravenous fluids and insulin. After around one week, they were transitioned to multiple shots of subcutaneous insulin. After about 4–6 weeks, their insulin requirement diminished and oral antihyperglycemic drugs were initiated. At the last follow-up (14 months), they had controlled glycemia with oral antihyperglycemic medicines. Conclusions COVID-19 can induce acute onset diabetes and DKA in some individuals with no history of diabetes. These features resemble type 1 diabetes. However, after 4–6 weeks, their requirement for exogenous insulin diminishes and respond to oral antihyperglycemic medications. Long term follow up is required to further understand the type of diabetes induced by SARS CoV-2 infection in these individuals., Highlights • In some individuals, COVID-19 induces diabetes resembling type 1 diabetes, characterized by acute onset and DKA. • However, their requirement for insulin diminishes after around 4–6 weeks. • Subsequently their diabetes can be controlled with oral antihyperglycemic medicines.

Aim: A preliminary analysis was done to evaluate the impact of lockdown on soil temperature at different depths and comparison with year 2018 and 2019. Methodology and Results: In order to describe the basic features of the data in study, descriptive statistics method was opted. The deviation in soil temperature in Rajouri District from mean value at 5 cm depth observed during lockdown was -8.58% and -4.77% compared to year 2018 and 2019. However the deviation observed from mean value at 10 cm depth was -10.72% and -9.28%. The deviation from mean value at 20 cm depth observed was -2.34% and -1.98%. The average change in soil temperature in Jammu District in morning at 5 cm, 10 cm and 20 cm depth was -3.46%, -3.84% and -7.23% as compared to year 2019 (22nd March to 10th June 2019) mean value and the change in soil temperature in evening at same depths was -7.69%, -6.31% and -4.14% from year 2019 (22nd March to 10th June 2019). The much focus is on Rajouri District as compared to Jammu, so tables and figures are representing Rajouri situation. Conclusion: The study concluded that due to lockdown, there was significant change in soil temperature values at variable depths compared to year 2018 and 2019 in the study region.

Aim: A preliminary analysis was done to evaluate the impact of lockdown on soil temperature at different depths and comparison with year 2018 and 2019. Methodology and Results: In order to describe the basic features of the data in study, descriptive statistics method was opted. The deviation in soil temperature in Rajouri District from mean value at 5 cm depth observed during lockdown was -8.58% and -4.77% compared to year 2018 and 2019. However the deviation observed from mean value at 10 cm depth was -10.72% and -9.28%. The deviation from mean value at 20 cm depth observed was -2.34% and -1.98%. The average change in soil temperature in Jammu District in morning at 5 cm, 10 cm and 20 cm depth was -3.46%, -3.84% and -7.23% as compared to year 2019 (22nd March to 10th June 2019) mean value and the change in soil temperature in evening at same depths was -7.69%, -6.31% and -4.14% from year 2019 (22nd March to 10th June 2019). The much focus is on Rajouri District as compared to Jammu, so tables and figures are representing Rajouri situation. Conclusion: The study concluded that due to lockdown, there was significant change in soil temperature values at variable depths compared to year 2018 and 2019 in the study region.

Aims: To study the feasibility of diabetes education through telemedicine in patients with diabetes mellitus (DM) hospitalized for coronavirus disease 2019 (COVID-19) management. Methods: This was a prospective study of 100 patients with DM who were admitted in a COVID isolation ward for management of COVID-19. Patients managed with multiple subcutaneous insulin injections were eligible. During teleconsultation, diabetes education including insulin injection technique was given by a diabetes educator via a phone call (audio and video) during hospitalization. They were also re-assessed after 2 weeks of discharge from the hospital via teleconsultation or in-person. Results: Out of 100 patients, 72.0% had prior history of diabetes while 28.0% were newly diagnosed. The median age of our cohort was 56 years and median duration of diabetes was 7.0 years. Telemedicine as a mode of consult for diabetes education was accepted by 96.0% of patients during hospitalization. At 2 weeks’ follow-up, 77.0% patients were following insulin instructions correctly and were satisfied with this mode of consultation. Conclusion: Diabetes education using telemedicine as a technology is feasible, acceptable, and effective in the management of most patients with DM. Telemedicine appears to be an effective way to replace routine visits in special situations.

This paper presents an optimized algorithm for event-triggered control (ETC) of networked control systems (NCS). Initially, the traditional backstepping controller is designed for a generalized nonlinear plant in strict-feedback form that is subsequently extended to the ETC. In the NCS, the controller and the plant communicate with each other using a communication network. In order to minimize the bandwidth required, the number of samples to be sent over the communication channel should be reduced. This can be achieved using the non-uniform sampling of data. However, the implementation of non-uniform sampling without a proper event triggering rule might lead the closed-loop system towards instability. Therefore, an optimized event triggering algorithm has been designed such that the system states are always forced to remain in stable trajectory. Additionally, the effect of ETC on the stability of backstepping control has been analyzed using the Lyapunov stability theory. Two case studies on an inverted pendulum system and single-link robot system have been carried out to demonstrate the effectiveness of the proposed ETC in terms of system states, control effort and inter-event execution time.

Terahertz metamaterial absorbers are the latest developments that have tremendous applications in terahertz spectroscopy and terahertz imaging. Especially, the research progressed in the direction of designing multiband absorbers. In this work, a polarization-insensitive metamaterial absorber capable of offering absorption in eight bands is proposed. The unit cell of the absorber consists of two orthogonal elliptical ring resonators (ERRs) that are optimally designed to offer maximum absorption in eight bands. The absorption percentage provided by the structure are 89.46% at 0.63 THz, 99.22% at 1.55 THz, 78.02% at 1.89 THz, 99.27% at 2.33 THz, 99.67% at 2.65 THz, 98.67% at 2.91 THz, 99.64% at 3.22 THz, and 88.02% at 3.42 THz. The absorption characteristics were independent of the polarization angle and thus, the structure is insensitive to variations in polarization angle. This is the first work that reports the design of an octaband terahertz absorber and can find significant use in practical devices.

Background Rapid increase of products containing titanium leads to the increases in percutaneous and permucosal exposure of populations to the titanium. Purpose Evaluate the various material compositions in five commercially available dental implant systems and correlate the obtained material contents with allergic conditions seen with implants. Material and methods A total of 25 implant, with 5 samples each in 5 groups of commercially available dental implants (MKIII, Myriad, Nobel Replace, MIS and Alpha Dent) were used in the study. Positive Material Identification (PMI) testing was done to analyse the amount of different metals (percentage by mass) present in the dental implants. Results Highest titanium content, 99.47% by mass was found in sample 2 (Myriad) and least, 89.04% by mass in sample 5(Alpha dent). Nickel was found only in sample 5 (Alpha dent) in 0.079% by mass and zinc in sample 4 (MIS) in0.084% by mass, chromium was found in sample 1 (MK III) in 0.263% by mass and in sample 2 in0.273% by mass. Conclusions Implant composition should be made mandatory to be disclosed on the implant packet and before implant placement patch test for the allergen present in the particular implant can be done for the patient's health benefit and long term clinical success of dental implants.

BACKGROUND AND PURPOSE The increased use of cell phones has raised many questions as to whether their use is safe for patients with dental implants. This study aimed to assess the consequences of cell phone-emitted radiation on bone-to-implant osseointegration during the healing phase. MATERIALS AND METHODS Twelve rabbits were grouped into three groups of four. Group 1 (control) was not exposed to electromagnetic radiation; group 2 (test) was exposed for 8 hours/day in speech mode and 16 hours/day in standby mode; and group 3 (test) was exposed for 24 hours continuously in standby mode for 3 months. Forty-eight implants were placed in tibia and femur bone of rabbits, and after 90 days the rabbits were sacrificed and bone surrounding the implant was retrieved. Histopathologic evaluations of the specimens were done using transmitted light microscope. The differences among the three groups were statistically analyzed with analysis of variance (ANOVA) and pairwise comparisons via Fisher's exact test. RESULTS Significantly less bone-to-implant contact and bone area surrounding implant threads were found in the test groups compared to the control group. There was a significant difference in regular bone formation (P < .001) among the three groups. CONCLUSION Implants exposed to cell phone radiation showed more inflammatory reaction when compared to the nonexposed implants, thus indicating that cellular phone overuse could affect the maturation of bone and thus delay osseointegration.

Diabetic muscle infarction (DMI) is an underreported complication of poorly controlled diabetes mellitus. We present clinical and laboratory data of two patients, a 27-year-old woman with Down syndrome and type 1 diabetes mellitus (T1DM) and a 47-year-old man with type 2 diabetes mellitus (T2DM) who presented with DMI. Poor control of T1DM and delayed diagnosis of T2DM were the major underlying factors in these cases. Although the condition responds well to conservative treatment, overall prognosis of patients is poor with respect to diabetes complications and mortality.

Reinwardtia indica (Lineceae) is a medicinal plant cultivated in the Himalayan region. It is effectively used in folk medicines for the treatment of various health complications. In the present study, the shade dried leaves and stem were extracted in three different solvents such as ethyl acetate, ethanol, and hydro-alcoholic. The antioxidant efficacy of these extracts was confirmed by using different in vitro assays: DPPH free radical scavenging, superoxide radical scavenging, lipid peroxidation, metal ion chelating capability and reducing power determination. Total phenol content was maximum in hydro alcoholic extract of leaf (540.37 mg per g of gallic acid equivalents) and stem (330.51 mg per g of gallic acid equivalents) while flavonoid content was maximum in ethanolic extract of leaf (305 mg per gram of rutin equivalents) and ethyl acetate extract of stem (170.6 mg per gram of rutin equivalents). The antioxidant activity of these extracts was positively correlated with their total phenol and flavonoid content. Among all tested extracts, ethanolic extract of leaf exhibit maximum zone of inhibition against all tested clinical isolates of bacterial (E. coli 11.00 ± 1.73 mm, P. aeurogenosa 11.67 ± 0.58 mm and S. aureus 10.33 ± 1.53 mm) and fungal (C. albicans 11.33 ± 1.10 mm) pathogens, while ethyl acetate extracts of the leaf and stem showed minimum inhibitory concentration against all tested microorganisms. Thus, R. indica extracts can be used as potent natural antioxidant having antifungal and antibacterial action.

Background: Lactic acidosis is a rare but serious complication associated with metformin therapy in certain high-risk patients. NICE guidelines and the British National Formulary advise the discontinuation of metformin before surgery. The drug manufacturer's datasheet advises the withdrawal of metformin 48 h before surgery. However, the data regarding perioperative use of metformin is scarce. Aims: To evaluate the effect of continuation of metformin till night before surgery on lactate levels in patients undergoing coronary artery bypass graft (CABG) surgery. Materials and Methods: In this prospective cohort study, 1,800 consecutive patients who underwent CABG between 1st November 2015 and 31st October 2016 were enrolled. Following exclusion criteria, a total of 790 subjects were included for final analysis. Three-hundred and eight seven (48.9%) patients with diabetes received metformin till night before surgery (Met group), 239 (30.3%) patients with diabetes were non-metformin users (Non-Met group), and 164 (20.8%) patients were having no diabetes (Non-Diab group). Lactate levels and arterial pH were measured using arterial blood gas machine. Postoperative morbidity outcome data were obtained by collecting clinical data, routine biochemistry, and chest imaging. Results: The mean metformin dose was 1,124.6 mg/day (SD: 509.3; range: 500–2,500 mg/day). Mean postoperative lactate levels were 1.91 ± 0.7 in Met group, 2.04 ± 0.79 in Non-Met group, and 2.07 ± 0.78 in Non-Diab group. Lactic acidosis occurred in 41 patients and there was no difference among the groups [Met group = 18 (4.7%); Non-Met group = 14 (5.9%)]. Among secondary outcome measures, acute renal failure occurred more frequently in diabetic patients [Met group = 46 (11.9%) and Non-Met group = 32 (13.4%)] as compared with non-diabetic patients. There were no differences with regard to pneumonia, length of ICU stay, and duration of ventilatory support among the three groups. Conclusions: Continuation of metformin till night before surgery is not associated with significant changes in lactate levels in patients undergoing CABG.

The conventional electrical grid is undergoing substantial growth for reliable grid operation and for more efficient and sustainable energy use. The traditional grid is now metamorphosing into a smart grid (SG) that incorporates a diverse, heterogeneous blend of operating measures such as smart appliances, meters, and renewable energy resources. With better efficient results and dependability, the SG can be described as a modern electric power grid architecture. The SG is one of the greatest potential advances as a promising solution for the energy crisis. However, it is complex and its decentralization could be of tremendous benefit. Moreover, digitalization and integration of a large number of growing connections make it a target of cyber-attacks. In this sense, blockchain is a promising SG paradigm solution that offers several excellent features. There has been considerable effort put into using blockchains in the smart grid for its decentralization and enhanced cybersecurity; however, it has not been thoroughly studied in both application and architectural perspectives. An in-depth study was conducted on blockchain-enabled SG applications. Blockchain architectures for various applications, such as the synchrophasor applications, electric vehicles, energy management systems, etc., were proposed. The purpose of this article is to provide directions for future research efforts aimed at secure and decentralized SG applications using blockchain.

The present study was designed to evaluate the ameliorative effect of ethyl acetate extract of Premna integrifolia L. (EAEPI) leaves in cyclophosphamide (CP)-induced hepatic injury in mice. Mice were intoxicated with CP (200 mg/kg b. wt., i.p.) for 5 weeks or EAEPI (400 and 600 mg/kg b. wt., orally) in combination with CP. The results demonstrated that EAEPI exerts protective effect against CP induced hepatotoxicity, as evident from restoration of altered haematological parameters and alleviations of liver marker enzymes in serum. EAEPI also attenuated oxidative stress and antioxidant markers as evident from reversal of lipid peroxidation, glutathione levels as well as activities of catalase and superoxide dismutase enzymes. Moreover, EAEPI attenuated apoptosis and histopathological liver tissue damage in CP-intoxicated mice. In conclusion, EAEPI could protect mice liver against cyclophosphamide toxicity by inhibiting oxidative stress and apoptosis.The protective activity of EAEPI may be due to presence of polyphenolic compounds as identified by UHPLC–Q-TOF-MS/MS.

Real time monitoring and control of a modern power system has achieved significant development since the incorporation of the phasor measurement unit (PMU). Due to the time-synchronized capabilities, PMU has increased the situational awareness (SA) in a wide area measurement system (WAMS). Operator SA depends on the data pertaining to the real-time health of the grid. This is measured by PMUs and is accessible for data analytics at the data monitoring station referred to as the phasor data concentrator (PDC). Availability of the communication system and communication delay are two of the decisive factors governing the operator SA. This paper presents a pragmatic metric to assess the operator SA and ensure optimal locations for the placement of PMUs, PDC, and the underlying communication infrastructure to increase the efficacy of operator SA. The uses of digital elevation model (DEM) data of the surface topography to determine the optimal locations for the placement of the PMU, and the microwave technology for communicating synchrophasor data is another important contribution carried out in this paper. The practical power grid system of Bihar in India is considered as a case study, and extensive simulation results and analysis are presented for validating the proposed methodology.

In Alzheimer Disease (AD) pathogenesis, aggregation of AβThis study aimed to investigate the neuroprotective role of FRAN in the AβDrosophila stocks: OregonRIn order to determine the most effective lethal dose of FRAN extract concentration 1, 2, 5, 10 mg/ml were screened using OregonRIn conclusion, FRAN extract rich in flavonoids as having largest neuroprotective activity against Aβ

The aetiology for the development of temporomandibular disorders (TMDs) is multifactorial. This chapter deals with several controversies that exist regarding the role of occlusion as main etiological factor for TMDs with the evidence of numerous studies for and against the role of occlusion in TMD. Insights have been provided regarding various concepts of occlusion and its relation to the disorders of the temporomandibular joint.

This work focuses on the design of a fractional-order PID (FOPID) controller for output stabilization of a fractional-order networked control system (FONCS). It is widely discussed that the real systems are fractional in nature and can be better modelled in terms of fractional order. It has been considered in this paper that the FONCS and FOPID controller communicate to each other through a dedicated communication channel. The control objective is to minimize the control updates in such way that the performance of the FONCS is on par with the performance of fractional-order system without communication channel. To minimize the control updates and to preserve the FONCS performance at its desired point, an event triggering rule has been suggested to appropriately drive the FONCS sample and hold circuit. The quantization error should be as low as possible while minimizing the number of control updates. Hence, a detailed analysis has been executed for selecting the triggering constant of the event triggering segment. The simulation results have been presented with a numerical example of FONCS with step signal as its reference input. It has been concluded that with appropriate event triggering algorithm, the FONCS can perform at its desired level even with lesser control updates.

Occlusal splints, where indicated, are vital for the treatment of temporomandibular joint disorders (TMDs). Use of occlusal splints for patients with TMDs is indicated to relieve any occlusal pressure causing uneven joint loading, reduce muscle pressure and symptoms of the joint disorders. There are various types of splints that are advocated to relieve TMD symptoms. Carefully selecting the type of splint and appropriate duration for usage of the splint therapy should be followed to achieve satisfactory results.