Search

Your search keyword '"Sun, Xin-Yuan"' showing total 398 results
Start Over Author "Sun, Xin-Yuan"
398 results on '"Sun, Xin-Yuan"'

110. Diethyl citrate and sodium citrate reduce the cytotoxic effects of nanosized hydroxyapatite crystals on mouse vascular smooth muscle cells

Author

Zhang,Chong-Yu, Sun,Xin-Yuan, Ouyang,Jian-Ming, Gui,Bao-Song, Zhang,Chong-Yu, Sun,Xin-Yuan, Ouyang,Jian-Ming, and Gui,Bao-Song

Abstract

Chong-Yu Zhang,1 Xin-Yuan Sun,1 Jian-Ming Ouyang,1 Bao-Song Gui2 1Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou, 2Department of Nephrology, The Second Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China Objective: This study aimed to investigate the damage mechanism of nanosized hydroxyapatite (nano-HAp) on mouse aortic smooth muscle cells (MOVASs) and the injury-inhibiting effects of diethyl citrate (Et2Cit) and sodium citrate (Na3Cit) to develop new drugs that can simultaneously induce anticoagulation and inhibit vascular calcification. Methods: The change in cell viability was evaluated using a cell proliferation assay kit, and the amount of lactate dehydrogenase (LDH) released was measured using an LDH kit. Intracellular reactive oxygen species (ROS) and mitochondrial damage were detected by DCFH-DA staining and JC-1 staining. Cell apoptosis and necrosis were detected by Annexin V staining. Intracellular calcium concentration and lysosomal integrity were measured using Fluo-4/AM and acridine orange, respectively. Results: Nano-HAp decreased cell viability and damaged the cell membrane, resulting in the release of a large amount of LDH. Nano-HAp entered the cells and damaged the mitochondria, and then induced cell apoptosis by producing a large amount of ROS. In addition, nano-HAp increased the intracellular Ca2+ concentration, leading to lysosomal rupture and cell necrosis. On addition of the anticoagulant Et2Cit or Na3Cit, cell viability and mitochondrial membrane potential increased, whereas the amount of LDH released, ROS, and apoptosis rate decreased. Et2Cit and Na3Cit could also chelate with Ca2+ to inhibit the intracellular Ca2+ elevations induced by nano-HAp, prevent lysosomal rupture, and reduce cell necrosis. High concentrations of Et2Cit and Na3Cit exhibited strong inhibitory effects. The inhibitory capacity of Na3Cit was stronger than that of Et2Cit at similar conc

Published
2017

111. Effects of Selenized AstragalusPolysaccharide on the Adhesion and Endocytosis of Nanocalcium Oxalate Dihydrate after the Repair of Damaged HK-2 Cells

Author

Huang, Fang, Sun, Xin-Yuan, Chen, Xue-Wu, and Ouyang, Jian-Ming

Abstract

An oxidative damage model of human proximal renal epithelial cells (HK-2) was established using oxalate damage. The repair effects of Astragaluspolysaccharide (APS) and selenized APS (Se-APS) on damaged HK-2 cells were investigated. Differences in the adhesion and endocytosis of HK-2 cells to calcium oxalate dihydrate crystals with a size of approximately 100 nm before and after APS and Se-APS repair were also explored. The results showed that after being repaired by APS and Se-APS, HK-2 cells exhibited increased cell viability, restored cell morphology, reduced reactive oxygen species level, increased mitochondrial membrane potential, reduced phosphatidylserine eversion, and osteopontin expression. Moreover, the amount of adherent crystals on the cell surface decreased, but the amount of endocytic crystals increased. At the same concentration, Se-APS exhibited better repair effects on the damaged HK-2 cells than APS. All these findings revealed that Se-APS may be a potential drug candidate for inhibiting the formation of kidney stones.

Published
2021
Full Text
View/download PDF

112. Generation of Cluster-Type Entangled Coherent States via Cross-Kerr Nonlinearity

Author

Luo Xiao-Bing, Sun Xin-Yuan, and Wang Wen-Feng

Subjects
Physics, business.industry, Kerr nonlinearity, Physics::Optics, General Physics and Astronomy, Photodetector, Quantum Physics, law.invention, Nonlinear system, Optics, Quantum gate, Homodyne detection, law, Quantum mechanics, Coherent states, business, Cluster type, Beam splitter
Abstract

We propose an optical scheme for the generation of the cluster-type entangled coherent states in free travelling optical fields via cross-Kerr nonlinearity. The required resources for the generation are coherent state source, beam splitters, photodetectors, and Kerr media. We also discuss the implementation of the Hadamard gate operation for coherent states and the homodyne detection.

Published
2008
Full Text
View/download PDF

115. Novel histone deacetylase inhibitor N25 exerts anti-tumor effects and induces autophagy in human glioma cells by inhibiting HDAC3

Author

Sun, Xin-Yuan, primary, Qu, Yue, additional, Ni, An-Ran, additional, Wang, Gui-Xiang, additional, Huang, Wei-Bin, additional, Chen, Zhong-Ping, additional, Lv, Zhu-Fen, additional, Zhang, Song, additional, Lindsay, Holly, additional, Zhao, Sibo, additional, Li, Xiao-Nan, additional, and Feng, Bing-Hong, additional

Published
2017
Full Text
View/download PDF

120. Superdense Tb3+‐activated borogermanate‐tellurite scintillating glasses.

Author

Sun, Xin‐Yuan, Wen, Zhuo‐Xing, Liu, Xiu‐Jian, Hu, Qiang‐Lin, Yang, Qing‐Mei, and Kang, Zhitao

Subjects
*GERMANATE glasses, *TELLURITES, *OPTICAL properties of metals, *LUMINESCENCE, *SCINTILLATORS
Abstract

Novel Tb3+‐activated borogermanate‐tellurite scintillating glasses with a maximum density of 7.15 g/cm3 aimed at detection of high‐energy rays were prepared by a melt‐quenching method for the first time. The concentration‐dependent optical properties including transmittance, photoluminescence, luminescence dynamic behaviors, and X‐ray excited luminescence in the as‐prepared Tb3+‐activated borogermanate‐tellurite glasses were studied. The optimal content of Tb2O3 in the superdense borogermanate‐tellurite glasses is revealed to be 7 mol% under both 275 nm ultraviolet light and X‐ray excitation. The integral scintillation efficiency of Tb3+‐activated borogermanate‐tellurite scintillating glass is about 33.71% of the standard Bi4Ge3O12 (BGO) scintillating crystal. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

122. Energy transfer study on dense and transparent Eu3+/Tb3+-coactivated TeO2-Gd2O3-WO3-ZnO glass scintillators☆

Author

Wu, Miaochun, Yu, Meidong, Cheng, Xi, Zhang, Guifang, Liu, Jiandi, Hu, Zuofu, Wen, Yufeng, Cui, Jiuzhi, Xiao, Zhuohao, and Sun, Xin-Yuan

Abstract

Tb3+-, Eu3+-activated and Eu3+/Tb3+-coactivated TeO2-Gd2O3-WO3-ZnO (TGWZ) glasses with the density of about 6.60 g/cm3were successfully synthesized by a melt-quenching method. These glass scintillators show a line transmittance coefficient in excess of 80% in the strongest green-emitting regions of Tb3+ions. The optimal concentration of incorporated Tb3+and Eu3+ions and the corresponding interaction mechanism are determined in both Tb3+and Eu3+-activated TGWZ glasses. Compared with that of Tb3+-activated TGWZ glasses, the luminous intensity of the Eu3+/Tb3+-coactivated TGWZ glasses is enhanced by 7.6 times, which can be attributed to the effective energy transfer (ET) from Tb3+to Eu3+ions. By investigating the concentration-dependent optical properties of these glasses including transmittance, photoluminescence (excitation and emission spectra), photoluminescence decay, the mechanism of ET in Eu3+/Tb3+-coactivated TGWZ glass scintillators is obtained. Also, the potential scintillation properties of the TGWZ glass scintillators are discussed by X-excited luminescence (XEL) spectra and the corresponding X-ray dose response tailored by various current intensity within 0–240 μA (which corresponding to 0–40000 mGy).

Published
2024
Full Text
View/download PDF

123. Mechanism of Porphyra YezoensisPolysaccharides in Inhibiting Hyperoxalate-Induced Renal Injury and Crystal Deposition

Author

Deng, Ji-Wang, Li, Chun-Yao, Huang, Ya-Peng, Liu, Wei-Feng, Zhang, Quan, Long, Jun, Wu, Wen-Qi, Huang, Ling-Hong, Zeng, Guo-Hua, and Sun, Xin-Yuan

Abstract

Oxidative damage to the kidneys is a primary factor in the occurrence of kidney stones. This study explores the inhibitory effect of Porphyra yezoensispolysaccharides (PYP) on oxalate-induced renal injury by detecting levels of oxidative damage, expression of adhesion molecules, and damage to intracellular organelles and revealed the molecular mechanism by molecular biology methods. Additionally, we validated the role of PYP in vivo using a crystallization model of hyperoxalate-induced rats. PYP effectively scavenged the overproduction of reactive oxygen species (ROS) in HK-2 cells, inhibited the adhesion of calcium oxalate (CaOx) crystals on the cell surface, unblocked the cell cycle, restored the depolarization of the mitochondrial membrane potential, and inhibited cell death. PYP upregulated the expression of antioxidant proteins, including Nrf2, HO-1, SOD, and CAT, while decreasing the expression of Keap-1, thereby activating the Keap1/Nrf2 signaling pathway. PYP inhibited CaOx deposition in renal tubules in the rat crystallization model, significantly reduced high oxalate-induced renal injury, decreased the levels of the cell surface adhesion proteins, improved renal function in rats, and ultimately inhibited the formation of kidney stones. Therefore, PYP, which has crystallization inhibition and antioxidant properties, may be a therapeutic option for the treatment of kidney stones.

Published
2024
Full Text
View/download PDF

124. Reinjury risk of nano-calcium oxalate monohydrate and calcium oxalate dihydrate crystals on injured renal epithelial cells: aggravation of crystal adhesion and aggregation

Author

Gan,Qiong-Zhi, Sun,Xin-Yuan, Bhadja,Poonam, Yao,Xiu-Qiong, Ouyang,Jian-Ming, Gan,Qiong-Zhi, Sun,Xin-Yuan, Bhadja,Poonam, Yao,Xiu-Qiong, and Ouyang,Jian-Ming

Abstract

Qiong-Zhi Gan,1,2 Xin-Yuan Sun,1,2 Poonam Bhadja,1,2 Xiu-Qiong Yao,1,2 Jian-Ming Ouyang1,2 1Department of Chemistry, Jinan University, Guangzhou, People’s Republic of China; 2Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou, People’s Republic of China Background: Renal epithelial cell injury facilitates crystal adhesion to cell surface and serves as a key step in renal stone formation. However, the effects of cell injury on the adhesion of nano-calcium oxalate crystals and the nano-crystal-induced reinjury risk of injured cells remain unclear.Methods: African green monkey renal epithelial (Vero) cells were injured with H2O2 to establish a cell injury model. Cell viability, superoxide dismutase (SOD) activity, malonaldehyde (MDA) content, propidium iodide staining, hematoxylin–eosin staining, reactive oxygen species production, and mitochondrial membrane potential (ΔΨm) were determined to examine cell injury during adhesion. Changes in the surface structure of H2O2-injured cells were assessed through atomic force microscopy. The altered expression of hyaluronan during adhesion was examined through laser scanning confocal microscopy. The adhesion of nano-calcium oxalate monohydrate (COM) and calcium oxalate dihydrate (COD) crystals to Vero cells was observed through scanning electron microscopy. Nano-COM and COD binding was quantitatively determined through inductively coupled plasma emission spectrometry.Results: The expression of hyaluronan on the cell surface was increased during wound healing because of Vero cell injury. The structure and function of the cell membrane were also altered by cell injury; thus, nano-crystal adhesion occurred. The ability of nano-COM to adhere to the injured Vero cells was higher than that of nano-COD crystals. The cell viability, SOD activity, and ΔΨm decreased when nano-crystals attached to the cell surface. By contrast, the M

Published
2016

132. Tunable luminescent properties of BaGd2O4:Eu3+ scintillating phosphors by Pr3+‐codoping.

Author

Sun, Xin‐Yuan, Zhu, Shou‐Bao, Xiao, Fen, Zhou, Shen‐Lin, and Li, Lu‐Nong

Abstract

BaGd2O4:Eu3+ scintillating phosphors by Pr3+‐codoping were synthesized at 1300°C in air using a solid‐state reaction method. The as‐synthesized phosphors were characterized by X‐ray diffraction (XRD), photoluminescence (PL) including excitation and emission spectra, radioluminescence (RL) spectra excited by X‐ray and thermoluminescence (TL) spectra. Both the PL and RL spectra are composed of the featured trivalent europium (Eu3+) without any praseodymium (Pr3+) ions, and the PL and RL intensities as well as the lifetimes of BaGd2O4:Eu3+ scintillating phosphors decrease dramatically with an increasing concentration of Pr3+ ions. Finally, the TL spectra reveal the trap concentration of the existing defects decrease with an increasing concentration of Pr3+ ions, while the relative TL intensity ratio of the high temperature band to the low temperature one increases with an increasing concentration of Pr3+ ions, which results in the afterglow suppression of BaGd2O4:Eu3+ scintillating phosphors. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

133. Role of Al3+ on tuning optical properties of Ce3+‐activated borosilicate scintillating glasses prepared in air.

Author

Sun, Xin‐Yuan, Xiao, Zhuo‐Hao, Wu, Yun‐Tao, Yu, Xiao‐Guang, Hu, Qiang‐Lin, Yuan, Yong, Liu, Qiang, Struebing, Christian, and Kang, Zhitao

Subjects
*BOROSILICATES, *OPTICAL properties of glass, *ALUMINUM, *CERIUM, *SILICON compounds
Abstract

Abstract: A colorless Ce3+‐activated borosilicate scintillating glass enriched with Gd2O3 is successfully synthesized in air atmosphere for the first time. The full replacement of 10 mol% BaO by Al2O3, and the partial substitution of 3 mol% SiO2 by Si3N4 in the designed glass composition are crucial for this success. The role of Al3+ on tuning the optical properties of Ce3+‐activated borosilicate scintillating glass synthesized in air are analyzed by optical transmittance, X‐ray absorption near edge spectroscopy (XANES) spectra, photoluminescence (PL) and radioluminescence (RL) spectra. The results suggest that the stable Ce4+ ions can be effectively reduced to stable Ce3+ ions by the full replacement of BaO by Al2O3, and both the PL andRL intensity of the designed borosilicate scintillating glass are enhanced by a factor of 6.7 and 5.2, respectively. The integral RL intensity of the synthesized Ce3+‐activated borosilicate scintillating glass is ~17.2%BGO, with a light output of about 1180 ph/MeV. The strategy of substituting BaO by Al2O3 will trigger more scientific and technological considerations in designing novel fast scintillating glasses. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

134. Effects of Porphyra yezoensisPolysaccharide with Different Molecular Weights on the Adhesion and Endocytosis of Nanocalcium Oxalate Monohydrate in Repairing Damaged HK-2 Cells

Author

Zhang, Hui, Sun, Xin-Yuan, and Ouyang, Jian-Ming

Abstract

The adhesion and endocytosis of renal epithelial cells to urinary microcrystals are closely related to kidney stone formation; however, the mechanism of cell state changes that affect adhesion and endocytosis remains unclear. In this study, a damaged cell model was established using oxalate to impair human kidney proximal tubular epithelial cells (HK-2). Then, we used four degraded Porphyra yezoensispolysaccharides (PYPs), namely, PYP1, PYP2, PYP3, and PYP4, with molecular weight of 576.2, 49.5, 12.6, and 4.02 kDa, respectively, to repair the damaged cells. After repairing the damaged HK-2 cells by PYPs, the cell morphology gradually recovered to near normal; the cell migration speed increased; the phosphatidylserine eversion ratio and osteopontin expression decreased; and the intracellular adenosine triphosphate was promoted. The adhesion and endocytosis of calcium oxalate monohydrate (COM) crystals were closely related to cell state. Normal cells could endocytose crystals more than the damaged cells, whereas damaged cells could adhere to crystals more than the normal cells. The cells repaired by PYPs inhibited the adhesion of nano-COM crystals and promoted the endocytosis of the adherent crystals, thereby reducing the adhesion of crystals on the cell surface under both effects. As the molecular weight of PYP decreased, the ability of PYP to repair cells, inhibit crystal adhesion, and promote endocytosis of cells was enhanced; that is, PYP4, which had the lowest molecular weight, exhibited the best biological activity. Therefore, PYPs, especially PYP4, may become an optional green drug to inhibit the formation and recurrence of calcium oxalate stones.

Published
2019
Full Text
View/download PDF

145. Fast Ce3+-activated borosilicate glass scintillators prepared in air atmosphere.

Author

Sun, Xin-Yuan, Xiao, Zhuo-Hao, Wu, Yun-Tao, and Kang, Zhitao

Subjects
*CERIUM compounds, *BOROSILICATES, *SCINTILLATORS, *CHEMICAL sample preparation, *AIR flow, *METAL quenching
Abstract

We report a simple synthesis method of a transparent and colorless Ce 3+ -activated borosilicate glass scintillator by conventional melt-quenching method in air atmosphere. The optical transmittance and X-ray absorption near edge spectroscopy (XANES) spectra imply that ceric ions (Ce 4+ ) can be effectively reduced to cerous one (Ce 3+ ) in borosilicate glass scintillator by substituting 40–60 mol% SiC for SiO 2 . Compared to the x =0 glass scintillator, both the photo- and radioluminescence intensity of the optimized borosilicate glass scintillator ( x =15 C) are enhanced by a factor of 6.5 and 7.7, respectively. The integral radioluminescence intensity of the x =15 C borosilicate glass scintillator resulted from the combined reduction effect of both SiC and graphite powder is about that of 14% bismuth germinate (BGO) crystal. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

147. Hydroxycitric acid inhibits kidney stone through crystallization regulation and reduction of hyperoxalate-induced lipotoxicity.

Author

Zhang, Yi-Han, Xian, Jun-Yi, Li, Shu-Jue, Li, Chun-Yao, Yu, Bang-Xian, Liang, Qing, Huang, Ling-Hong, Zeng, Guo-Hua, and Sun, Xin-Yuan

Abstract

[Display omitted] • HCA can effectively inhibit CaOx crystal deposition. • HCA can effectively inhibit the lipid deposition and reduce lipid nephrotoxicity. • HCA inhibits lipid nephrotoxicity by activating the PPARα pathway. • HCA has a better inhibition of CaOx crystal formation compared to CA. Kidney stone is a urinary system disease with a high incidence, and effective stone drugs are limited. Hydroxycitric acid (HCA), mainly found in Garcinia cambogia and Hibiscus sabdariffa , can reduce body weight and calcium salt deposition. In this study, we explored the molecular mechanisms of HCA inhibition of renal calcium oxalate (CaOx) deposition and nephrotoxicity in an oxalate-induced cell model and rat model. HCA could effectively inhibit CaOx crystal deposition and reduce crystal adhesion and oxidative damage. Further cellular transcriptomic analysis and in vitro results showed that HCA could stably bind peroxisome proliferator-activated receptor α (PPAR α), thus promoting the expression of downstream oxidative stress molecules and inhibiting calcium ion release and mitochondrial dysfunction, thus reducing oxalate-induced renal lipid peroxidation damage. HCA, a drug with the ability to modulate lipid metabolism and inhibit CaOx formation, may be a therapeutic option for the treatment of oxalate nephropathies. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results