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363 results on '"Sultana, Naznin"'

101. Sleep Problems in Children with Autism Spectrum Disorder in Bangladesh : A Case-Control Study

Author

Sultana, Naznin, Asaduzzaman, Md, al Mamun, Firoj, Hosen, Ismail, Yu, Qian, Pakpour, Amir H., Gozal, David, Mamun, Mohammed A., Sultana, Naznin, Asaduzzaman, Md, al Mamun, Firoj, Hosen, Ismail, Yu, Qian, Pakpour, Amir H., Gozal, David, and Mamun, Mohammed A.

Abstract

Background: Sleep problems in children with Autism Spectrum Disorder (ASD) are highly prevalent, but little information is available on this issue in low- to middle-income countries (LMIC) such as Bangladesh. Therefore, the present study investigated the prevalence and socio-demographic determinants of ASD sleep disturbances in a comparison with typically developing children (TDC). Methods: A cross-sectional interview study was carried out within a total of 446 Bangladeshi mothers, whose children's mean age was 8.1 +/- 2.9 years (151 ASD [8.5 +/- 2.7 years] and 295 TDC [7.9 +/- 2.9 years]); in addition to socio-demographics, the Child Sleep Habit Questionnaire (CSHQ) was used, and a cut-off score of 41 out of 93 points considered as reflecting sleep problems. Results: About 89.7% of the children reported having problems in sleep, with ASD reporting higher frequency vs TDC (94.00% vs 87.50%; chi(2)=4.678, p=0.031). The overall mean CSHQ score was 48.7 +/- 7.6 in total sample, whereas ASD children reported higher scores compared to TDCs (50.9 +/- 8.1 vs 47.5 +/- 7.0, p< 0.001). Similarly, subscales of CSHQ such as sleep duration (4.23 +/- 1.56 vs 3.90 +/- 1.31, p=0.017), sleep anxiety (7.23 +/- 2.05 vs 6.45 +/- 1.92, p< 0.001), night waking (3.82 +/- 1.07 vs 3.17 +/- 1.89, p< 0.001), parasomnias (8.86 +/- 2.06 vs 7.85 +/- 2.27, p< 0.001), and sleep disordered breathing (4.02 +/- 2.92 vs 3.43 +/- 2.07, p=0.014) were more problematic among ASD compared to TDC. Lastly, 28.5% of ASD reported taking sleep-related medications vs 0.3% for TDC (n=1). Conclusion: Bangladeshi ASD children are highly likely to manifest sleep disturbances, which warrant urgent implementation of parental educational and support programs to mitigate the impact of sleep problems in ASD families.

Published
2021
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102. Sleep Problems in Children with Autism Spectrum Disorder in Bangladesh: A Case–Control Study

Author

Sultana,Naznin, Asaduzzaman,Md, al Mamun,Firoj, Hosen,Ismail, Yu,Qian, Pakpour,Amir H, Gozal,David, Mamun,Mohammed A, Sultana,Naznin, Asaduzzaman,Md, al Mamun,Firoj, Hosen,Ismail, Yu,Qian, Pakpour,Amir H, Gozal,David, and Mamun,Mohammed A

Abstract

Naznin Sultana,1,2 Md Asaduzzaman,3 Firoj al Mamun,1,4 Ismail Hosen,1,4 Qian Yu,5 Amir H Pakpour,6,7 David Gozal,8 Mohammed A Mamun1,4 1CHINTA Research Bangladesh (Centre for Health Innovation, Networking, Training, Action and Research – Bangladesh), Savar, Dhaka, Bangladesh; 2Department of Public Health, North South University, Dhaka, Bangladesh; 3Department of Public Health, American International University – Bangladesh, Dhaka, Bangladesh; 4Department of Public Health and Informatics, Jahangirnagar University, Savar, Dhaka, Bangladesh; 5Exercise Psychophysiology Laboratory, Institute of KEEP Collaborative Innovation, School of Psychology, Shenzhen University, Shenzhen, 518060, People’s Republic of China; 6Social Determinants of Health Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran; 7Department of Nursing, School of Health and Welfare, Jönköping University, Jönköping, Sweden; 8Department of Child Health and the Child Health Research Institute, The University of Missouri School of Medicine, Columbia, MO, USACorrespondence: Qian YuExercise Psychophysiology Laboratory, Institute of KEEP Collaborative Innovation, School of Psychology, Shenzhen University, 518060, People’s Republic of ChinaEmail yuqianmiss@163.comMohammed A MamunCHINTA Research Bangladesh, Savar, Dhaka, 1342, BangladeshTel +880-1738592653Email mamunphi46@gmail.comBackground: Sleep problems in children with Autism Spectrum Disorder (ASD) are highly prevalent, but little information is available on this issue in low- to middle-income countries (LMIC) such as Bangladesh. Therefore, the present study investigated the prevalence and socio-demographic determinants of ASD sleep disturbances in a comparison with typically developing children (TDC).Methods: A cross-sectional interview study was carried out within a total of 446 Bangladeshi mothers, who

Published
2021

106. An mRNA-based vaccine candidate against SARS-CoV-2 elicits stable immuno-response with single dose

Author

Nag, Kakon, primary, Chandra Baray, Juwel, additional, Rahman Khan, Maksudur, additional, Mahmud, Asif, additional, Islam, Jikrul, additional, Myti, Sanat, additional, Ali, Rostum, additional, Haq Sarker, Enamul, additional, Kumar, Samir, additional, Hossain Chowdhury, Mobarak, additional, Roy, Rony, additional, Islam, Faqrul, additional, Barman, Uttam, additional, Khan, Habiba, additional, Chakraborty, Sourav, additional, Badsha, Alam, additional, Hossain, Manik, additional, Ahammad, Shamim, additional, Rahman Chowdhury, Mashfiqur, additional, Ghosh, Polash, additional, Islam Shimul, Rayhanul, additional, Ahmmed, Ronzu, additional, Hussain Bhuiya, Eleus, additional, Kumar Biswas, Bipul, additional, Mohiuddin, Mohammad, additional, and Sultana, Naznin, additional

Published
2021
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117. BANCOVID, the first D614G variant mRNA-based vaccine candidate against SARS-CoV-2 elicits neutralizing antibody and balanced cellular immune response

Author

Baray, Juwel Chandra, primary, Khan, Md. Maksudur Rahman, additional, Mahmud, Asif, additional, Islam, Md. Jikrul, additional, Myti, Sanat, additional, Ali, Md. Rostum, additional, Sarker, Md. Enamul Haq, additional, Kumar, Samir, additional, Chowdhury, Md. Mobarak Hossain, additional, Roy, Rony, additional, Islam, Faqrul, additional, Barman, Uttam, additional, Khan, Habiba, additional, Chakraborty, Sourav, additional, Hossain, Md. Manik, additional, Chowdhury, Md. Mashfiqur Rahman, additional, Ghosh, Polash, additional, Mohiuddin, Mohammad, additional, Sultana, Naznin, additional, and Nag, Kakon, additional

Published
2020
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123. Does Vitamin D3 supplementation affect antioxidant enzymes of D3 deficient patients with asthma COPD overlap (ACO)? - A randomized controlled trial

Author

Mahmud, Maksuda Bintey, primary, Ali, Taskina, primary, Bennoor, Kazi Saifuddin, primary, Hossain, Md Ali, primary, Rahman, Mustafizur, primary, Khan, Mohammad Abdus Shakur, primary, Islam, Md Saiful, primary, Hassan, Samia, primary, Nahar, Salsa Bil, primary, Rosy, Sharkia Khanam, primary, Sultana, Naznin, primary, and Anjum, Salma, primary

Published
2020
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134. THE EFFECTS OF DIMMER CONTROLLED ATMOSPHERIC PRESSURE PLASMA JET TO THE BIOPHYSICAL STRUCTURES OF HeLa CELLS.

Author

CHIN FHONG SOON, NAYAN, NAFARIZAL, SULTANA, NAZNIN, MORSIN, MARLIA, GIM PAO LIM, NYUK LING MA, ELFA RIZAN RIZON, and KIAN SEK TEE

Subjects
PLASMA jets, CELL anatomy, ATMOSPHERIC pressure, PLASMA flow, ARGON plasmas
Abstract

Non-thermal atmospheric pressure plasma jet (NTAPPJ) was shown as a promising tool for sterilization, treatment of chronic wounds & tumors. A portable and facile NTAPPJ system will broaden the application of plasma for many other biomedical applications. This paper demonstrates the feasibility of a customized dimmer controllable atmospheric pressure plasma jet (APPJ) in treating HeLa cells. A plasma torch was energized at 8 kVpp and 35 kHz from a neon transformer and discharged with argon gas-producing plasma plume of various gas species. The output intensity of the plasma discharge was adjusted by the voltage input from the dimmer controller circuit. Between 60 - 220 V, a different power output of the dimmer can be varied between 8.4 to 83.6 W, to generate different intensities of non-thermal APPJ (NTAPPJ). The NTAPPJ was then applied to HeLa cells for 20 sec & it was found that cells reduced their adhesion at a dimmer power < 20 W but stayed viable. This progressed to observations of damaged cell body when the power was increased beyond 20 W & the cell membranes shattered when the power was up to 83.6 W. This was due to the ultraviolet rays and reactive oxygen species (ROS), that induced detrimental effects to the cells. The controllable NTAPPJ system, based on dimmer control, induced different levels of effects on the biophysical structures of cells, ranging from reduced cell spread to apoptosis and eventually cell membrane disintegration. [ABSTRACT FROM AUTHOR]

Published
2020

135. Effects of Atmospheric Pressure Plasma Jet Treatment Duration to the Viability of HeLa Cells and Microtissues.

Author

Chin Fhong Soon, Phriya, Mohana, Rizon, Elfa Rizan, Abdul Hamid, Intan Sue Liana, Sultana, Naznin, Morsin, Marlia, Kian Sek Tee, Gim Pao Lim, Ahmad, Mohd Khairul, and Nayan, Nafarizal

Subjects
PLASMA jets, HELA cells, CELL survival, TREATMENT duration, NON-thermal plasmas, EMISSION spectroscopy
Abstract

Non-thermal atmospheric plasma jet (NTAPPJ) is believed to be effective in treating monolayer cells cultured in-vitro due to the oxidative stresses induced. However, it is controversial whether studying the impact of plasma to cells in monolayer can be representative to a model close to the in-vivo tissues. This study revealed and compared the effects of NTAPPJ treatment directly to both monolayer of HeLa cells and microspheroids in the culture media, at different exposure time from 15 to 60 seconds at a fixed power of 80 W. Optical emission spectroscopy (OES) revealed that the plasma applied to the cells is rich in hydroxyl, nitrogen, oxygen and argon species. The experimental results revealed that the treatment time from 15 seconds onwards was detrimental to the monolayer of cells, but not to the spheroids compared with the negative controls. After long NTAPPJ exposure, the HeLa cells in the spheroids were found viable, regardless of the plasma exposure time applied. The multicellular structure of the spheroids has prevented the penetration of free radicals into the cells encapsulated in the spheroids. [ABSTRACT FROM AUTHOR]

Published
2020

143. Characterization of the zebrafish cx36.7 gene promoter: Its regulation of cardiac-specific expression and skeletal muscle-specific repression

Author

miyagi, hisako, NAG, KAKON, Nag, Kakon, Sultana, Naznin, Munakata, Keijiro, HIROSE, SHIGEHISA, and Nakamura, Nobuhiro

Subjects
0301 basic medicine, Heart malformation, Molecular Sequence Data, Repressor, Connexin, GATA Transcription Factors, Connexins, 03 medical and health sciences, Genetics, Animals, Amino Acid Sequence, Muscle, Skeletal, Promoter Regions, Genetic, Zebrafish, Embryonic heart, biology, GATA4, Myocardium, Gene Expression Regulation, Developmental, Promoter, Heart, General Medicine, Zebrafish Proteins, biology.organism_classification, Molecular biology, 030104 developmental biology, embryonic structures, GATA transcription factor
Abstract

Zebrafish connexin 36.7 (cx36.7/ecx) has been identified as a key molecule in the early stages of heart development in this species. A defect in cx36.7 causes severe heart malformation due to the downregulation of nkx2.5 expression, a result which resembles congenital heart disease in humans. It has been shown that cx36.7 is expressed specifically in early developing heart cardiomyocytes. However, the regulatory mechanism for the cardiac-restricted expression of cx36.7 remains to be elucidated. In this study we isolated the 5'-flanking promoter region of the cx36.7 gene and characterized its promoter activity in zebrafish embryos. Deletion analysis showed that a 316-bp upstream region is essential for cardiac-restricted expression. This region contains four GATA elements, the proximal two of which are responsible for promoter activation in the embryonic heart and serve as binding sites for gata4. When gata4, gata5 and gata6 were simultaneously knocked down, the promoter activity was significantly decreased. Moreover, the deletion of the region between -316 and -133bp led to EGFP expression in the embryonic trunk muscle. The distal two GATA and A/T-rich elements in this region act as repressors of promoter activity in skeletal muscle. These results suggest that cx36.7 expression is directed by cardiac promoter activation via the two proximal GATA elements as well as by skeletal muscle-specific promoter repression via the two distal GATA elements.

Published
2015

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