101. GATA Regulation and Function During the Ovarian Life Cycle.
- Author
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Bennett-Toomey J and Stocco C
- Subjects
- Animals, Apoptosis, Embryonic Development, Extracellular Matrix physiology, Female, Follicular Atresia, GATA Transcription Factors antagonists & inhibitors, GATA Transcription Factors genetics, Humans, Luteinization, Menstrual Cycle, Oogenesis, Ovary cytology, Ovary embryology, Ovary growth & development, Ovulation, Aging, GATA Transcription Factors metabolism, Gene Expression Regulation, Developmental, Models, Biological, Ovary physiology, Reproduction
- Abstract
GATA4 and GATA6 are the sole GATA factors expressed in the ovary during embryonic development and adulthood. Up today, GATA4 and GATA6 are the only transcription factors that have been conditionally deleted during ovarian development and at each major stage of follicle maturation. The evidence from these transgenic mice revealed that GATA4 and GATA6 are crucial for follicles assembly, granulosa cell differentiation, postnatal follicle growth, and luteinization. Thus, conditional knockdown of both factors in the granulosa cells at any stage of development leads to female infertility. GATA targets impacting female reproduction include genes involved in steroidogenesis, hormone signaling, ovarian hormones, extracellular matrix organization, and apoptosis/cell division., (© 2018 Elsevier Inc. All rights reserved.)
- Published
- 2018
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