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1,191 results on '"Spina, Michele"'

101. Simplified Geriatric Assessment in Older Patients With Diffuse Large B-Cell Lymphoma: The Prospective Elderly Project of the Fondazione Italiana Linfomi

Author

Merli, Francesco, primary, Luminari, Stefano, additional, Tucci, Alessandra, additional, Arcari, Annalisa, additional, Rigacci, Luigi, additional, Hawkes, Eliza, additional, Chiattone, Carlos S., additional, Cavallo, Federica, additional, Cabras, Giuseppina, additional, Alvarez, Isabel, additional, Fabbri, Alberto, additional, Re, Alessandro, additional, Puccini, Benedetta, additional, Barraclough, Allison, additional, Delamain, Marcia Torresan, additional, Ferrero, Simone, additional, Usai, Sara Veronica, additional, Ferrari, Angela, additional, Cencini, Emanuele, additional, Pennese, Elsa, additional, Zilioli, Vittorio Ruggero, additional, Marino, Dario, additional, Balzarotti, Monica, additional, Cox, Maria Christina, additional, Zanni, Manuela, additional, Di Rocco, Alice, additional, Lleshi, Arben, additional, Botto, Barbara, additional, Hohaus, Stefan, additional, Merli, Michele, additional, Sartori, Roberto, additional, Gini, Guido, additional, Nassi, Luca, additional, Musuraca, Gerardo, additional, Tani, Monica, additional, Bottelli, Chiara, additional, Kovalchuk, Sofia, additional, Re, Francesca, additional, Flenghi, Leonardo, additional, Molinari, Annalia, additional, Tarantini, Giuseppe, additional, Chimienti, Emanuela, additional, Marcheselli, Luigi, additional, Mammi, Caterina, additional, and Spina, Michele, additional

Published
2021
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102. Biosensor-based screening method for the detection of aflatoxins [B.sub.1]-[G.sub.1]

Author

Cuccioloni, Massimiliano, Mozzicafreddo, Matteo, Barocci, Simone, Ciuti, Francesca, Pecorelli, Ivan, Eleuteri, Anna Maria, Spina, Michele, Fioretti, Evandro, and Angeletti, Mauro

Subjects
Plasmons (Physics) -- Properties, Resonance -- Research, Neutrophils -- Properties, Biosensors -- Usage, Aflatoxins -- Properties, Biological assay -- Methods, Corn -- Diseases and pests, Chemistry
Abstract

Aflatoxins are extremely toxic metabolites from Aspergillus species that can adulterate a wide range of human foodstuff. Herein, we propose a novel assay designed as an analytical test for aflatoxin [B.sub.1] and [G.sub.1] (AF[B.sub.1] and AF[G.sub.1], respectively) that could represent an alternative screening technique for this class of mycotoxins. The approach for the determination of these toxins is based on surface plasmon resonance using neutrophil porcine elastase as a 'bait' for these aflatoxins. The selection and optimization of the analytical procedure involved a preliminary investigation on the type of inhibition by AF[B.sub.1]: the level of the protease inhibition exerted by AF[B.sub.1] depended upon the incubation time and the concentration of the binding partners, showing the competitiveness and the reversibility of the inhibition. A posteriori, the nature of the interaction granted a rapid analysis, a single detection test requiring only a few minutes. For the development of the assay, the experimental conditions were evaluated and optimized with both calibration solution and aflatoxin-spiked samples. To apply this method to aflatoxin-contaminated maize, a rapid solid-phase extraction treatment was developed. The proposed assay for AF[B.sub.1] and AF[G.sub.1] was validated by comparison with both a chromatographic reference method and a standard enzyme linked immunosorbent assay procedure. This enzyme-based biosensor represents a new approach for the detection of aflatoxins based on the reversible interaction between a blocked macromolecule and a soluble ligand, having the major advantages in the relative rapidity, the reusability of the capturing surface, and low cost per single test.

Published
2008

105. Characterization of immunologic and virological parameters in HIV-infected patients with primary effusion lymphoma during antiblastic therapy and highly active antiretroviral therapy

Author

Simonelli, Cecilia, Tedeschi, Rosamaria, Gloghini, Annunziata, Bortolin, Maria Teresa, Spina, Michele, Bidoli, Ettore, Cinelli, Roberta, De Paoli, Paolo, Carbone, Antonino, and Tirelli, Umberto

Subjects
Highly active antiretroviral therapy -- Health aspects, Lymphomas -- Risk factors, Lymphomas -- Research, HIV patients -- Health aspects, Health, Health care industry
Published
2005

111. Impact of concomitant antiblastic chemotherapy and highly active antiretroviral therapy on human immunodeficiency virus (HIV) viremia and genotyping in HIV-infected patients with non-hodgkin lymphoma

Author

Simonelli, Cecilia, Zanussi, Stefania, Cinelli, Roberta, Dal Maso, Luigino, Di Gennaro, Giampiero, D'Andrea, Monica, Nasti, Guglielmo, Spina, Michele, Vaccher, Emanuela, De Paoli, Paolo, and Tirelli, Umberto

Subjects
Antiviral agents -- Drug use, Chemotherapy, Viremia -- Care and treatment, HIV (Viruses) -- Genetic aspects, HIV (Viruses) -- Drug therapy, Statistics, Communicable diseases -- Research, Health, Health care industry
Published
2003

118. Early progression as a predictor of survival in marginal zone lymphomas: an analysis from the FIL-NF10 study

Author

Luminari, Stefano, Merli, Michele, Rattotti, Sara, Tarantino, Vittoria, Marcheselli, Luigi, Cavallo, Federica, Varettoni, Marzia, Bianchi, Benedetta, Merli, Francesco, Tedeschi, Alessandra, Cabras, Giuseppina, Re, Francesca, Visco, Carlo, Torresan Delamain, Marcia, Cencini, Emanuele, Spina, Michele, Ferrero, Simone, Ferrari, Angela, Deodato, Marina, Mannina, Donato, Annibali, Ombretta, Rago, Angela, Orsucci, Lorella, Defrancesco, Irene, Frigeni, Marco, Cesaretti, Marina, and Arcaini, Luca

Published
2019
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122. A dose‐dense short‐term therapy for human immunodeficiency virus/acquired immunodeficiency syndrome patients with high‐risk Burkitt lymphoma or high‐grade B‐cell lymphoma: safety and efficacy results of the “CARMEN” phase II trial

Author

Ferreri, Andrés J. M., primary, Cattaneo, Chiara, additional, Lleshi, Arben, additional, Verga, Luisa, additional, Allione, Bernardino, additional, Facchetti, Fabio, additional, Ponzoni, Maurilio, additional, Foppoli, Marco, additional, Ferrari, Daris, additional, Rigacci, Luigi, additional, Pecciarini, Lorenza, additional, Donadoni, Giovanni, additional, Fumagalli, Luca, additional, Sassone, Marianna, additional, Calimeri, Teresa, additional, Rossi, Giuseppe, additional, Spina, Michele, additional, and Re, Alessandro, additional

Published
2020
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123. Long‐lasting efficacy and safety of lenalidomide maintenance in patients with relapsed diffuse large B‐cell lymphoma who are not eligible for or failed autologous transplantation

Author

Ferreri, Andrés J. M., primary, Sassone, Marianna, additional, Angelillo, Piera, additional, Zaja, Francesco, additional, Re, Alessandro, additional, Di Rocco, Alice, additional, Spina, Michele, additional, Fabbri, Alberto, additional, Stelitano, Caterina, additional, Frezzato, Maurizio, additional, Volpetti, Stefano, additional, Zambello, Renato, additional, Rusconi, Chiara, additional, De Lorenzo, Daniela, additional, Scarano, Eloise, additional, Arcari, Annalisa, additional, Bertoldero, Giovanni, additional, Nonis, Alessandro, additional, Calimeri, Teresa, additional, Perrone, Salvatore, additional, Cecchetti, Caterina, additional, Tarantino, Vittoria, additional, Steffanoni, Sara, additional, Foppoli, Marco, additional, Ciceri, Fabio, additional, and Ponzoni, Maurilio, additional

Published
2020
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125. Clinical characteristics of interim-PET negative patients with a positive end PET from the prospective HD08-01 FIL study

Author

Rigacci, Luigi, primary, Puccini, Benedetta, additional, Broccoli, Alessandro, additional, Dona, Manjola, additional, Gotti, Manuel, additional, Evangelista, Andrea, additional, Santoro, Armando, additional, Bonfichi, Maurizio, additional, Re, Alessandro, additional, Spina, Michele, additional, Botto, Barbara, additional, Pulsoni, Alessandro, additional, Pagani, Chiara, additional, Stelitano, Caterina, additional, Salvi, Flavia, additional, Nassi, Luca, additional, Mannelli, Lara, additional, Kovalchuk, Sofia, additional, Gioia, Daniela, additional, and Zinzani, Pier Luigi, additional

Published
2019
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127. Oxaliplatin Based Chemotherapy and Concomitant Highly Active Antiretroviral Therapy in the Treatment of 24 Patients with Colorectal Cancer and HIV Infection

Author

Berretta, Massimiliano, Lleshi, Arben, Cappellani, Alessandro, Bearz, Alessandra, Spina, Michele, Talamini, Renato, Cacopardo, Bruno, Nunnari, Giuseppe, Montesarchio, Vincenzo, Izzi, Immacolata, Lanzafame, Massimiliano, Nasti, Guglielmo, Basile, Francesco, Berretta, Salvatore, Fisichella, Rossella, Clara, Schiantarelli C, Garlassi, Elisa, Ridolfo, Annalisa, Guella, Lorenza, and Tirelli, Umberto

Published
2010

129. Genome wide DNA-profiling of HIV-related B-cell lymphomas

Author

Capello, Daniela, Scandurra, Marta, Poretti, Giulia, Rancoita, Paola M. V., Mian, Michael, Gloghini, Annunziata, Deambrogi, Clara, Martini, Maurizio, Rossi, Davide, Greiner, Timothy C., Chan, Wing C., Ponzoni, Maurilio, Moreno, Santiago M., Piris, Miguel A., Canzonieri, Vincenzo, Spina, Michele, Tirelli, Umberto, Inghirami, Giorgio, Rinaldi, Andrea, Zucca, Emanuele, Favera, Riccardo D., Cavalli, Franco, Larocca, Luigi Maria, Kwee, Ivo, Carbone, Antonino, Gaidano, Gianluca, and Bertoni, Francesco

Published
2010
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130. Studies on the connective tissue matrix components of the arterial wall of humans and salmonids (Salmo gairdneri and Salmo salar) : age-and species-related physical and chemical properties

Author

Spina, Michele Attilio and Serafini-Fracassini, Augusto

Subjects
612.1, QP106.2S7, Arterial. Aorta
Abstract

Section A of this thesis describes the non-degradative isolation procedure of elastin from the media of human thoracic aorta and the determination of its ponderal distribution as well as that of the other connective tissue matrix components in the aortic media of individuals of different ages. A cylindrical segment, free of complex atherosclerotic lesions, was resected at autopsy from each of fifty-nine descending human thoracic aortae by cutting just below the level of the first pair of intercostal arteries and 35 mm distal to this incision. In the isolated tunica media there was an age-related rise in the absolute concentration of the following components: (a) proteins and glycoproteins extractable in chaotropic agents, (b) collagen and (c) an insoluble polar protein(s) which was resistant to collagenase digestion but was solubilized by trypsin. In contrast, the absolute elastin concentration was constant at around 70 mg/cm in samples of all ages. Although after treatment with collagenase and trypsin, both the mechanical properties and amino acid composition of elastin did not vary with age, in samples tested prior to trypsin digestion the insoluble polar-protein contaminant affected the mechanical behaviour of the elastin network in a way akin to plasticisers in rubber. It is therefore suggested that the morphological changes .and stiffening observed in the ageing aortic wall are not due to degradation of its elastin network bu to variations in the supramolecular organisation of connective tissue components. Section B of this thesis describes the isolation of elastin and the determination of its distribution as well as that of collagen in the bulbus arteriosus and ventral aorta of trout (Salmo gairdneri) and salmon (Salmo salar). The isolation of elastin fibrils from these specimens did not require the use of proteolytic enzymzes as collagen and all the other components of the vessel wall were readily extracted in denaturing and reducing conditions. The arterial walls of trout and salmon are characterized by a high elastin content, with an elastin:collagen ratio exceeding 2.5:1. The elastin which display an amino acid composition highly at variance with that of the mammalian protein, is present as 250-A-diameter fibrils which have a strong affinity for electron-dense cations and which form in the intercellular matrix an isotropic reticulum. As in mammalian elastin, the fibrils can be resolved in negatively contrasted preparations into constituent primary filaments of about 25 A in diameter, aligned with an equatorial periodicity of about 55 A. The wide-angle X-ray diffraction pattern of the salmonid preparations showed broad reflections corresponding to spacings of 9.8, 4.5 and 2.2 A, similar to bovine elastin. The mechanical behaviour of the salmon preparation was characterized by a linear response to stress, with minimal hysteresis, a Young's modulus of 5.5 x 105 N m-2, and a breaking strain of 1.5.

Published
1982

137. Role of the HLA Class II: HCV-Related Disorders

Author

DE RE, VALLI, CAGGIARI, LAURA, SIMULA, MARIA PAOLA, DE VITA, SALVATORE, MAZZARO, CESARE, LENZI, MARCO, MASSIMO, GALLI M., MONTI, GIUSEPPE, FERRI, CLODOVEO, ZIGNEGO, ANNA LINDA, GABRIELLI, ARMANDO, SANSONNO, DOMENICO, DAMMACCO, FRANCO, LIBRA, MASSIMO, SACCHI, NICOLETTA, TALAMINI, RENATO, SPINA, MICHELE, TIRELLI, UMBERTO, CANNIZZARO, RENATO, and DOLCETTI, RICCARDO

Published
2007

142. Lymphoma in the immunosuppressed

Author

Spina, Michele, primary, Marcus, Robert, additional, Tirelli, Umberto, additional, Wotherspoon, Andrew, additional, Rosenwald, Andreas, additional, and Ott, German, additional

Published
2001
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148. High-Dose Therapy and Autologous Peripheral-Blood Stem-Cell Transplantation As Salvage Treatment for HIV-Associated Lymphoma in Patients Receiving Highly Active Antiretroviral Therapy

Author

Re, Alessandro, Cattaneo, Chiara, Michieli, Mariagrazia, Casari, Salvatore, Spina, Michele, Rupolo, Maurizio, Allione, Bernardino, Nosari, Annamaria, Schiantarelli, Clara, Viganò, Mariagrazia, Izzi, Immacolata, Ferremi, Piero, Lanfranchi, Arnalda, Mazzuccato, Maurizio, Carosi, Gianpiero, Tirelli, Umberto, and Rossi, Giuseppe

Published
2003

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