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104. Localization of an ataxia-telangiectasia gene to chromosome 11q22-23

Author

Gatti, Richard A., Berkel, Izzet, Boder, Elena, Braedt, Gary, Charmley, Patrick, Concannon, Patrick, Ersoy, Fugen, Foroud, Tatiana, Jaspers, Nicholas G.J., Lange, Kenneth, Lathrop, G. Mark, Leppert, Mark, Nakamura, Yasuke, O'Connell, Peter, Paterson, Malcolm, Salser, Winston, Sanal, Ozden, Silver, Jack, Sparkes, Robert S., Susi, Ellen, Weeks, Daniel E., Wei, Shan, White, Ray, and Yoder, Freda

Subjects
Genetic disorders -- Research, Ataxia telangiectasia -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Published
1988

106. Substitution reactions of the ammine complexes of palladium (II)

Author

Reinhardt, Richard A., Sparkes, Robert Kenneth, Reinhardt, Richard A., and Sparkes, Robert Kenneth

Abstract

The following substitution reactions involving the square complexes of palladium (II) in aqueous HC1 solution were studied by spectrophotometric and potentiometric methods..., http://www.archive.org/details/substitutionreac00spar, Lieutenant Commander, Royal Canadian Navy

Published
2012

108. Wilms' tumor-aniridia association: Segregation of affected chromosome in somatic cell hybrids, identification of cell surface antigen associated with deleted area, and regional mapping of c-Ha-ras-1 oncogene, insulin gene, and beta-globin gene

Author

The Cancer Research Laboratory in the Department of Otorhinolaryngology and Department of Microbiology and Immunology, University of Michigan, 48109, Ann Arbor, Michigan, Eleanor Roosevelt Institute for Cancer Research (contribution number 427), Webb-Waring Lung Institute and Division of Pulmonary Sciences, Section on Human Genetics, Department of Medicine, University of Colorado Health, 80262, Denver, Colorado, Division of Medical Genetics, Departments of Medicine, Pediatrics, and Psychiatry, UCLA Center for the Health Sciences, 90024, Los Angeles, California, Ann Arbor, Kimmel, Kathryn A., Sparkes, Robert S., Miller, York E., Fisher, James H., Bateman, J. Brownwyn, Carey, Thomas E., Rodell, Timothy, Shoemaker, Steven A., Scoggin, Charles H., The Cancer Research Laboratory in the Department of Otorhinolaryngology and Department of Microbiology and Immunology, University of Michigan, 48109, Ann Arbor, Michigan, Eleanor Roosevelt Institute for Cancer Research (contribution number 427), Webb-Waring Lung Institute and Division of Pulmonary Sciences, Section on Human Genetics, Department of Medicine, University of Colorado Health, 80262, Denver, Colorado, Division of Medical Genetics, Departments of Medicine, Pediatrics, and Psychiatry, UCLA Center for the Health Sciences, 90024, Los Angeles, California, Ann Arbor, Kimmel, Kathryn A., Sparkes, Robert S., Miller, York E., Fisher, James H., Bateman, J. Brownwyn, Carey, Thomas E., Rodell, Timothy, Shoemaker, Steven A., and Scoggin, Charles H.

Abstract

Fusion of an auxotrophic mutant hamster cell with the skin fibroblasts of a child with the Wilms' tumor-aniridia association produced clones which, on the one hand, contained the child's normal chromosome 11 and, on the other, the chromosome 11 with the 11p13 deletion associated with the syndrome. Both hybrids were positive for human LDH-A by enzymatic assay. Clones containing the normal human chromosome 11 were killed by a cytotoxic monoclonal antibody to a cell surface antigen previously mapped to the 11p13??? 11pter region of chromosome 11. Clones with the abnormal 11 were not killed. Thus, we have produced hybrids from the same patient distinct from each other on the basis of their chromosome 11. These hybrids have been used to map the locus for a cell surface antigen to the deleted region on chromosome 11 of a patient with the Wilms tumor-aniridia association. The linkage between this antigen and the syndrome should be helpful in further study of the genetics of this disease. In addition, we have found that the c-Ha-ras-1 oncogene is distal to the p13 region of chromosome 11 and the position of insulin and beta-globin on the chromosome. Finally, by producing segregants of the hybrids containing the abnormal chromosome 11, we have provided evidence that chromosome 11-associated c-Ha-ras-1 is syntenic with chromosome 11 and not moved to a different portion of the genome.

Published
2006

109. Genetic influences on spatial ability: Transmission in an extended kindred

Author

Department of Pathology, University of Michigan, 48109, Ann Arbor, Michigan, Division of Medical Genetics, Departments of Psychiatry, Medicine and Pediatrics, University of California School of Medicine, 90024, Los Angeles, California, Department of Psychiatry 48 241 NPI, University of California School of Medicine, 760 Westwood Plaza, 90024, Los Angeles, California, Eric Marder and Associates, 122 East 42nd Street, 10168, New York, New York, Ann Arbor, Smalley, Susan L., Thompson, Andrea Lee, Spence, M. Anne, Judd, W. John, Sparkes, Robert S., Department of Pathology, University of Michigan, 48109, Ann Arbor, Michigan, Division of Medical Genetics, Departments of Psychiatry, Medicine and Pediatrics, University of California School of Medicine, 90024, Los Angeles, California, Department of Psychiatry 48 241 NPI, University of California School of Medicine, 760 Westwood Plaza, 90024, Los Angeles, California, Eric Marder and Associates, 122 East 42nd Street, 10168, New York, New York, Ann Arbor, Smalley, Susan L., Thompson, Andrea Lee, Spence, M. Anne, Judd, W. John, and Sparkes, Robert S.

Abstract

Transmission of six spatial tests, Card Rotations, Cube Comparisons, Group Embedded Figures, Hidden Patterns, Mental Rotations, and portable Rod and Frame, is examined among 73 members in four generations of an extended kindred. Nonadditive genetic variance is substantial for one of the six tests, Card Rotations. Whether this nonadditive genetic variance is due to a major autosomal gene is equivocal based on results from segregation and linkage analysis. There is no evidence for genetic variance for Mental Rotations or Hidden Patterns, in contrast to previous findings suggesting major gene involvement (Ashton et al., 1979). If spatial ability is due, in part, to an autosomal major gene, the gene has variable expression (reflected in different tests) or genetic heterogeneity is pronounced.

Published
2006

113. 6-GHz analog transistors, ECL team up in versatile array

Author

Sparkes, Robert and Gross, Winthrop

Subjects
Semiconductor industry, Standard IC, Tektronix Inc. -- Product introduction, Semiconductor industry -- Product introduction, Integrated circuits -- Innovations -- Product introduction, Semiconductor chips -- Innovations -- Product introduction
Abstract

6-GHz analog transistors, ECL team up in versatile array In monolithic structures, analog and digital circuits make uneasy bedfellows. Digital circuitry takes large numbers of small-geometry transistors, some specific resistor […]

Published
1986

130. Tumor suppressor genes

Author

Sparkes, Robert F.

Subjects
Retinoblastoma -- Genetic aspects, Tumor suppressor genes -- Physiological aspects -- Genetic aspects, Nephroblastoma -- Genetic aspects, Health, Physiological aspects, Genetic aspects
Abstract

Tumor Suppressor Genes THE HIGH FREQUENCY of cytogenetic, chromosomal, or single gene changes in most tumors had led to the concept that tumors represent a somatic cell genetic disease. With [...]

Published
1991

134. Lafora Progressive Myoclonus Epilepsy: Narrowing the Chromosome 6q24 Locus by Recombinations and Homozygosities

Author

Sainz, Jesus, primary, Minassian, Berge A., additional, Serratosa, Jose M., additional, Gee, Manyee N., additional, Sakamoto, Lise M., additional, Iranmanesh, Reza, additional, Bohlega, Saeed, additional, Baumann, Robert J., additional, Ryan, Steve, additional, Sparkes, Robert S., additional, and Delgado-Escueta, Antonio V., additional

Published
1997
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138. Genetic Heterogeneity in the Epilepsies

Author

Delgado-Escueta, Antonio. V., primary, Serratosa, Jose M., additional, Liu, Amy, additional, Weissbecker, Karen, additional, Medina, Marco T., additional, Gee, Manyee, additional, Treiman, Lucy J., additional, and Sparkes, Robert S., additional

Published
1994
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141. Progress in Mapping Human Epilepsy Genes

Author

Delgado-Escueta, Antonio V., primary, Serratosa, Jose M., additional, Liu, Amy, additional, Weissbecker, Karen, additional, Medina, Marco T., additional, Gee, Manyee, additional, Treiman, Lucy J., additional, and Sparkes, Robert S., additional

Published
1994
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147. Allelic association of the D2 dopamine receptor gene with cocaine dependence

Author

Noble, Ernest P., primary, Blum, Kenneth, additional, Khalsa, M.Elena, additional, Ritchie, Terry, additional, Montgomery, Anne, additional, Wood, Robert C., additional, Fitch, Robert J., additional, Ozkaragoz, Tulin, additional, Sheridan, Peter J., additional, Anglin, M.Douglas, additional, Paredes, Alfonso, additional, Treiman, Lucy J., additional, and Sparkes, Robert S., additional

Published
1993
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