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102. Minced skin grafts for chronic wounds compared to conventional mesh grafts.

Author

Sanches‐Pinto, Débora C., Eriksson, Elof, Gomez, David S., Nunes, Maria P. T., Gemperli, Rolf, and Soriano, Francisco G.

Abstract

Background and Aims: Skin grafting is the single most effective method to close a chronic wound. The current standard of care is to use meshed split thickness skin grafts. This entails the use of surgical instruments that need to be autoclaved and to have a power source, which usually requires an OR facility. The minced skin technique uses single use, presterilized instruments and the procedure can be done under local anesthesia, by a wound care practitioner, in a wound clinic, a physician's office or even at the bedside. The current study was designed to determine if the results from micrografting were non inferior to conventional mesh grafting. Methods: In a prospective non inferiority study, 26 chronic ulcers were treated with micrografting (MSG) and 24 with conventional mesh grafts 1:3 (control group‐CG) in a total of 21 patients, 10 male and 11 female. The donor site areas in the MSG group were predetermined to 2.5 × 5 cm and the mesh grafts expansion was set at 1:3. Results: In the first weeks postoperatively, micrograft healing initially lagged behind the conventional mesh grafts but at 60 days after grafting, all MSG wounds were healed. The MSG wounds had better pigmentation, less itching, and less scarring. The micrografting procedure was easy to learn and expeditious to perform. The MSG mean expansion was 9.1 compared to three times (CG). Conclusion: The MSG procedure is not inferior to conventional mesh grafting, requires smaller donor sites, and can be done with single use instruments, under local anesthesia, with early discharge. Key points: Skin grafting is usually the best option to close chronic wounds.We need simplified methods, such as minced skin grafting, with less morbidity for outpatient skin grafting.Minced skin grafting and mesh grafting had similar healing rates at 60 days.The donor sites in the mesh graft group were three times larger than those of the minced skin grafts for the same size recipient area. [ABSTRACT FROM AUTHOR]

Published
2023
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105. The Role of Cytokines in Cancer Cachexia

Author

Argilés, Josep M., Busquets, Sílvia, Moore-Carrasco, Rodrigo, López-Soriano, Francisco J., Mantovani, Giovanni, editor, Anker, Stefan D., editor, Inui, Akio, editor, Morley, John E., editor, Fanelli, Filippo Rossi, editor, Scevola, Daniele, editor, Schuster, Michael W., editor, and Yeh, Shing-Shing, editor

Published
2006
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106. Cancer Cachexia and Fat Metabolism

Author

Argilés, Josep M., Almendro, Vanessa, Busquets, Sílvia, López-Soriano, Francisco J., Mantovani, Giovanni, editor, Anker, Stefan D., editor, Inui, Akio, editor, Morley, John E., editor, Fanelli, Filippo Rossi, editor, Scevola, Daniele, editor, Schuster, Michael W., editor, and Yeh, Shing-Shing, editor

Published
2006
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111. Effects of the PARP Inhibitor Olaparib on the Response of Human Peripheral Blood Leukocytes to Bacterial Challenge or Oxidative Stress

Author

Santos, Sidneia Sousa, primary, Brunialti, Milena Karina Coló, additional, Rodrigues, Larissa de Oliveira Cavalcanti Peres, additional, Liberatore, Ana Maria Alvim, additional, Koh, Ivan Hong Jun, additional, Martins, Vanessa, additional, Soriano, Francisco Garcia, additional, Szabo, Csaba, additional, and Salomão, Reinaldo, additional

Published
2022
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112. Local and systemic inflammation: role of poly (ADP-ribose) synthetase activation by reactive nitrogen species

Author

Mabley, Jon, Liaudet, Lucas, Soriano, Francisco Garcia, Virág, László, Jagtap, Prakash, Marton, Anita, Lorigados, Clara Batista, Gallyas, Ferenc, Szabó, Éva, Abdelkarim, Galaleldin E., Haskó, György, Southan, Garry J., Salzman, Andrew L., Szabó, Csaba, Parnham, Michael J., editor, Salvemini, Daniela, editor, Billiar, Timothy R., editor, and Vodovotz, Yoram, editor

Published
2001
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114. Cancer Cachexia

Author

Argilés, Josep M., López-Soriano, Francisco J., Busquets, Sílvia, and Lang, Florian, editor

Published
2009
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116. Physical activity, muscle strength, and exercise capacity 3 months after severe sepsis and septic shock

Author

Borges, Rodrigo Cerqueira, Carvalho, Celso R. F., Colombo, Alexandra Siqueira, da Silva Borges, Mariucha Pereira, and Soriano, Francisco Garcia

Subjects
Exercise -- Analysis, Infection -- Analysis, Medical colleges -- Analysis, Hospital patients -- Analysis, Physical fitness -- Analysis, Septic shock -- Analysis, Health care industry
Abstract

Purpose To quantify the physical activity in daily life (PADL), muscle strength, and exercise capacity in the short and medium term in survivors of severe sepsis and septic shock. Methods Prospective cohort study with a follow-up from hospital admission to 3 months after hospital discharge. Seventy-two patients admitted to the ICU for severe sepsis or septic shock and a control group of healthy sedentary subjects (n = 50) were enrolled. All patients had their PADL quantified by an accelerometer during their hospital stay and 3 months after. Exercise capacity and handgrip and quadriceps muscle strength were also evaluated. Results During hospitalization, patients spent the majority of their time inactive in a lying or sitting position (90 ± 34 % of daily time). Physical inactivity was partially reduced 3 months after (58 ± 20 % of daily time). However, the time patients spent walking was only 63 % of the time reported for healthy subjects. Patients also showed lower movement intensity when compared with controls (2.1 ± 0.3 vs 2.5 ± 0.4 m/s.sup.2). At hospital discharge, muscle strength and exercise capacity were approximately 54 % of the predicted value, and these parameters showed significant increase in patients 3 months after (70 % of predicted value). Multivariable analysis demonstrated that the use of systemic corticosteroids and hospitalization time negatively influenced quadriceps strength and exercise capacity at the time of hospital discharge. Conclusion Our results suggest that survivors of sepsis admitted to the ICU have a substantial reduction in physical activity, exercise capacity, and muscle strength compared to healthy subjects that persist even 3 months after hospital discharge., Author(s): Rodrigo Cerqueira Borges [sup.1], Celso R. F. Carvalho [sup.2], Alexandra Siqueira Colombo [sup.1], Mariucha Pereira da Silva Borges [sup.1], Francisco Garcia Soriano [sup.1] [sup.3] Author Affiliations: (1) grid.11899.38, 0000000419370722, [...]

Published
2015
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117. Myocarditis in a young male affected with monkeypox infection: a case report.

Author

Pérez, Sergio Luengo, Lizarraga, Julián Abdala, Ferrer, Esther Jaén, and Soriano, Francisco Ridocci

Abstract

Background Concerns on monkeypox as a disease impacting global public health first emerged in May, 2022, and, since that time, has been identified in more than 50 countries. The condition mainly affects men who have sex with other men. Cardiac disease is a rare complication of monkeypox infection. Here, we describe a case of myocarditis in a young male subsequently diagnosed with monkeypox infection. Case summary A 42-year-old male reported engaging in high-risk sexual behaviours with another male 10 days before presenting to the emergency department with chest pain, fever, maculopapular rash, and a necrotic chin lesion. Electrocardiography revealed diffuse concave ST-segment elevation associated with elevated cardiac biomarkers. Transthoracic echocardiography revealed normal biventricular systolic function without wall motion abnormalities. We excluded other sexually transmitted diseases or viral infections. Cardiac magnetic resonance imaging (MRI) findings suggested myopericarditis involving the lateral wall and adjacent pericardium. The results of polymerase chain reaction (PCR) tests of pharyngeal, urethral, and blood samples were positive for monkeypox. The patient was treated with high-dose non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine and he recovered soon. Discussion Monkeypox infections are generally self-limited, with most patients experiencing benign clinical outcomes, no hospitalizations, and few complications. This is a rare report of monkeypox complicated with myopericarditis. Management with high-dose NSAIDs and colchicine relieved our patient's symptoms, suggesting a similar clinical outcome as other idiopathic or virus-related myopericarditis. [ABSTRACT FROM AUTHOR]

Published
2023
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131. Toll-like receptor ligand-peptide conjugates in the immunomodulatory response of food allergy

Author

Palomares Jerez, Maria Francisca, primary, Losada, Jorge, additional, Gomez, Francisca, additional, Sanchez, Natalia Perez, additional, Cañas Mañas, Jose Antonio, additional, Rondon, Carmen, additional, Eguiluz-Gracia, Ibon, additional, Ramos Soriano, Francisco Javier, additional, Montañez, María Isabel, additional, Torres, Maria Jose, additional, Rojo, Javier, additional, and Mayorga, Cristobalina, additional

Published
2022
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132. Mean Velocity of the Pulmonary Artery as a Clinically Relevant Prognostic Indicator in Patients with Heart Failure with Preserved Ejection Fraction

Author

Trejo-Velasco, Blanca, primary, Cruz-González, Ignacio, additional, Barreiro-Pérez, Manuel, additional, Díaz-Peláez, Elena, additional, García-González, Pilar, additional, Martín-García, Ana, additional, Eiros, Rocío, additional, Merchán-Gómez, Soraya, additional, Pérez del Villar, Candelas, additional, Fabregat-Andrés, Oscar, additional, Ridocci-Soriano, Francisco, additional, and Sánchez, Pedro L., additional

Published
2022
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136. Ly6c as a New Marker of Mouse Blood Vessels: Qualitative and Quantitative Analyses on Intact and Ischemic Retinas

Author

Martínez-Carmona, Marina, primary, Lucas-Ruiz, Fernando, additional, Gallego-Ortega, Alejandro, additional, Galindo-Romero, Caridad, additional, Norte-Muñoz, María, additional, González-Riquelme, María José, additional, Valiente-Soriano, Francisco J., additional, Vidal-Sanz, Manuel, additional, and Agudo-Barriuso, Marta, additional

Published
2021
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139. Coadministration of Branched-Chain Amino Acids and Lipopolysaccharide Causes Matrix Metalloproteinase Activation and Blood–Brain Barrier Breakdown

Author

Scaini, Giselli, Morais, Meline O. S., Galant, Leticia S., Vuolo, Francieli, Dall’Igna, Dhébora M., Pasquali, Matheus A. B., Ramos, Vitor M., Gelain, Daniel P., Moreira, Jose Claudio F., Schuck, Patrícia F., Ferreira, Gustavo C., Soriano, Francisco G., Dal-Pizzol, Felipe, and Streck, Emilio L.

Published
2014
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143. Retinal neurodegeneration in experimental glaucoma

Author

Vidal-Sanz, Manuel, primary, Valiente-Soriano, Francisco J., additional, Ortín-Martínez, Arturo, additional, Nadal-Nicolás, Francisco M., additional, Jiménez-López, Manuel, additional, Salinas-Navarro, Manuel, additional, Alarcón-Martínez, Luis, additional, García-Ayuso, Diego, additional, Avilés-Trigueros, Marcelino, additional, Agudo-Barriuso, Marta, additional, and Villegas-Pérez, Maria P., additional

Published
2015
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