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101. Follicular fluid during individual oocyte maturation enhances cumulus expansion and improves embryo development and quality in a dose-specific manner

Author: Azari-Dolatabad, Nima, Raes, Annelies, Pavani, Krishna Chaitanya, Asaadi, Anise, Angel-Velez, Daniel, Van Damme, Petra, Leroy, Jo L.M.R., Van Soom, Ann, and Pascottini, Osvaldo Bogado
Published: 2021
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102. Quantification of Arctic Soil and Permafrost Properties Using Ground-Penetrating Radar and Electrical Resistivity Tomography Datasets

Author: Leger, E, Dafflon, B, Soom, F, Peterson, J, Ulrich, C, and Hubbard, S
Subjects: Arctic, electrical resistance measurement, geophysical measurements, ground penetrating radar, Physical Geography and Environmental Geoscience, Artificial Intelligence and Image Processing, Geomatic Engineering
Abstract: Improving understanding of Arctic ecosystem climate feedback and parameterization of models that simulate freeze-Thaw dynamics require advances in quantifying soil and snow properties. Due to the significant spatiotemporal variability of soil properties and the limited information provided by point-scale measurements (e.g., cores), geophysical methods hold potential for improving soil and permafrost characterization. In this study, we evaluate the use of a ground-penetrating radar (GPR) to estimate thaw layer thickness, snow depth, and ice-wedge characteristics in an ice-wedge-dominated tundra region near Barrow, AK, USA. To this end, we analyze GPR and point-scale measurements collected along several parallel transects at the end of the growing season and the end of frozen season. In addition, we compare the structural information extracted from the GPR data with electrical resistivity tomography (ERT) information about ice-wedge characteristics. Our study generally highlights the value of GPR data collected in the frozen season, when conditions lead to the improved GPR signal-To-noise ratio, facilitate data acquisition, and reduce acquisition-related ecosystem disturbance relative to growing season. We document for the first time that GPR data collected during the frozen season can provide reliable estimates of active layer thickness and geometry of ice wedges. We find that the ice-wedge geometry extracted from GPR data collected during the frozen season is consistent with ERT data, and that GPR data can be used to constrain the ERT inversion. Consistent with recent studies, we also find that GPR data collected during the frozen season can provide good estimates of snow thickness, and that GPR data collected during the growing season can provide reliable estimate thaw depth. Our quantification of the value of the GPR and ERT data collected during growing and frozen seasons paves the way for coupled inversion of the datasets to improve understanding of permafrost variability.
Published: 2017

103. Quantification of Arctic Soil and Permafrost Properties Using Ground-Penetrating Radar and Electrical Resistivity Tomography Datasets

Author: Lger, Emmanuel, Dafflon, Baptiste, Soom, Florian, Peterson, John, Ulrich, Craig, and Hubbard, Susan
Subjects: Earth Sciences, Physical Geography and Environmental Geoscience, Arctic, electrical resistance measurement, geophysical measurements, ground penetrating radar, Artificial Intelligence and Image Processing, Geomatic Engineering, Physical geography and environmental geoscience, Geomatic engineering, Applied computing
Abstract: Improving understanding of Arctic ecosystem climate feedback and parameterization of models that simulate freeze-Thaw dynamics require advances in quantifying soil and snow properties. Due to the significant spatiotemporal variability of soil properties and the limited information provided by point-scale measurements (e.g., cores), geophysical methods hold potential for improving soil and permafrost characterization. In this study, we evaluate the use of a ground-penetrating radar (GPR) to estimate thaw layer thickness, snow depth, and ice-wedge characteristics in an ice-wedge-dominated tundra region near Barrow, AK, USA. To this end, we analyze GPR and point-scale measurements collected along several parallel transects at the end of the growing season and the end of frozen season. In addition, we compare the structural information extracted from the GPR data with electrical resistivity tomography (ERT) information about ice-wedge characteristics. Our study generally highlights the value of GPR data collected in the frozen season, when conditions lead to the improved GPR signal-To-noise ratio, facilitate data acquisition, and reduce acquisition-related ecosystem disturbance relative to growing season. We document for the first time that GPR data collected during the frozen season can provide reliable estimates of active layer thickness and geometry of ice wedges. We find that the ice-wedge geometry extracted from GPR data collected during the frozen season is consistent with ERT data, and that GPR data can be used to constrain the ERT inversion. Consistent with recent studies, we also find that GPR data collected during the frozen season can provide good estimates of snow thickness, and that GPR data collected during the growing season can provide reliable estimate thaw depth. Our quantification of the value of the GPR and ERT data collected during growing and frozen seasons paves the way for coupled inversion of the datasets to improve understanding of permafrost variability.
Published: 2017

104. Oxidative stress in donor mares for ovum pick-up delays embryonic development

Author: Voortplanting paard, Fertility & Reproduction, Hedia, Mohamed, Angel-Velez, Daniel, Papas, Marion, Peere, Sofie, Gerits, Ilse, De Coster, Tine, Van den Branden, Emma, Govaere, Jan, Van Soom, Ann, Leroy, Jo L.M.R., Smits, Katrien, Voortplanting paard, Fertility & Reproduction, Hedia, Mohamed, Angel-Velez, Daniel, Papas, Marion, Peere, Sofie, Gerits, Ilse, De Coster, Tine, Van den Branden, Emma, Govaere, Jan, Van Soom, Ann, Leroy, Jo L.M.R., and Smits, Katrien
Published: 2024

105. Comprehending the evolution of gene editing platforms for crop trait improvement

Author: Priyanka Dhakate, Deepmala Sehgal, Samantha Vaishnavi, Atika Chandra, Apekshita Singh, Soom Nath Raina, and Vijay Rani Rajpal
Subjects: CRISPR/Cas system, base editing, prime editing, epigenome editing, crop improvement, Genetics, QH426-470
Abstract: CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas (CRISPR-associated) system was initially discovered as an underlying mechanism for conferring adaptive immunity to bacteria and archaea against viruses. Over the past decade, this has been repurposed as a genome-editing tool. Numerous gene editing-based crop improvement technologies involving CRISPR/Cas platforms individually or in combination with next-generation sequencing methods have been developed that have revolutionized plant genome-editing methodologies. Initially, CRISPR/Cas nucleases replaced the earlier used sequence-specific nucleases (SSNs), such as zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs), to address the problem of associated off-targets. The adaptation of this platform led to the development of concepts such as epigenome editing, base editing, and prime editing. Epigenome editing employed epi-effectors to manipulate chromatin structure, while base editing uses base editors to engineer precise changes for trait improvement. Newer technologies such as prime editing have now been developed as a “search-and-replace” tool to engineer all possible single-base changes. Owing to the availability of these, the field of genome editing has evolved rapidly to develop crop plants with improved traits. In this review, we present the evolution of the CRISPR/Cas system into new-age methods of genome engineering across various plant species and the impact they have had on tweaking plant genomes and associated outcomes on crop improvement initiatives.
Published: 2022
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106. Influence of soil heterogeneity on soybean plant development and crop yield evaluated using time-series of UAV and ground-based geophysical imagery

Author: Nicola Falco, Haruko M. Wainwright, Baptiste Dafflon, Craig Ulrich, Florian Soom, John E. Peterson, James Bentley Brown, Karl B. Schaettle, Malcolm Williamson, Jackson D. Cothren, Richard G. Ham, Jay A. McEntire, and Susan S. Hubbard
Subjects: Medicine, Science
Abstract: Abstract Understanding the interactions among agricultural processes, soil, and plants is necessary for optimizing crop yield and productivity. This study focuses on developing effective monitoring and analysis methodologies that estimate key soil and plant properties. These methodologies include data acquisition and processing approaches that use unmanned aerial vehicles (UAVs) and surface geophysical techniques. In particular, we applied these approaches to a soybean farm in Arkansas to characterize the soil–plant coupled spatial and temporal heterogeneity, as well as to identify key environmental factors that influence plant growth and yield. UAV-based multitemporal acquisition of high-resolution RGB (red–green–blue) imagery and direct measurements were used to monitor plant height and photosynthetic activity. We present an algorithm that efficiently exploits the high-resolution UAV images to estimate plant spatial abundance and plant vigor throughout the growing season. Such plant characterization is extremely important for the identification of anomalous areas, providing easily interpretable information that can be used to guide near-real-time farming decisions. Additionally, high-resolution multitemporal surface geophysical measurements of apparent soil electrical conductivity were used to estimate the spatial heterogeneity of soil texture. By integrating the multiscale multitype soil and plant datasets, we identified the spatiotemporal co-variance between soil properties and plant development and yield. Our novel approach for early season monitoring of plant spatial abundance identified areas of low productivity controlled by soil clay content, while temporal analysis of geophysical data showed the impact of soil moisture and irrigation practice (controlled by topography) on plant dynamics. Our study demonstrates the effective coupling of UAV data products with geophysical data to extract critical information for farm management.
Published: 2021
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107. Predicting the Academic Achievement of Students Bridging to Engineering: The Role of Academic Background Variables and Diagnostic Testing

Author: Van den Broeck, Lynn, De Laet, Tinne, Lacante, Marlies, Pinxten, Maarten, Van Soom, Carolien, and Langie, Greet
Abstract: Although the number of engineering students is increasing, dropout rates remain high. This problem is also present in the Faculty of Engineering Technology (FET) at KU Leuven, Belgium, which resulted in the need for an in-depth analysis of the academic achievement of the bridging students there. This study examines the contribution of a range of predictors, both cognitive and non-cognitive. The examined predictors are: general characteristics, academic background variables and variables tested in a diagnostic test. A multiple linear regression model for the 2015-2016 chohort accounted for an explained variance of 36% of the students' academic achievement. After combining three cohorts, we managed to explain 43% of the variance in students' academic achievement. As expected, the academic background variables are the most important predictors. The diagnostic tests are less predictive but their role is important, since they encourage students to participate in associated interventions.
Published: 2019
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108. Challenging the Hypothesis of in Utero Microbiota Acquisition in Healthy Canine and Feline Pregnancies at Term: Preliminary Data

Author: Penelope Banchi, Barbara Colitti, Andrea Del Carro, Michela Corrò, Alessia Bertero, Ugo Ala, Angela Del Carro, Ann Van Soom, Luigi Bertolotti, and Ada Rota
Subjects: feto-maternal microbiota, dog, cat, fetus, pregnancy, Veterinary medicine, SF600-1100
Abstract: At present, there are no data on the presence of bacteria in healthy canine and feline pregnancies at term. Here, we investigated the uterine microbiome in bitches (n = 5) and queens (n = 3) undergoing elective cesarean section in two facilities. Samples included swabs from the endometrium, amniotic fluid, and meconium, and environmental swabs of the surgical tray as controls. Culture and 16S rRNA gene sequencing were used to investigate the presence of bacteria. Culture was positive for 34.3% of samples (uterus n = 3, amniotic fluid n = 2, meconium n = 4, controls n = 0), mostly with low growth of common contaminant bacteria. With sequencing techniques, the bacterial abundance was significantly lower than in environmental controls (p < 0.05). Sequencing results showed a species-specific pattern, and significant differences between canine and feline bacterial populations were found at order, family, and genus level. No differences were found in alpha and beta diversities between feto-maternal tissues and controls (p > 0.05). Dominant phyla were Bacteroidetes, Firmicutes, and Proteobacteria in different proportions based on tissue and species. Culture and sequencing results suggest that the bacterial biomass is very low in healthy canine and feline pregnancies at term, that bacteria likely originate from contamination from the dam’s skin, and that the presence of viable bacteria could not be confirmed most of the time.
Published: 2023
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109. Alternative Culture Systems for Bovine Oocyte In Vitro Maturation: Liquid Marbles and Differentially Shaped 96-Well Plates

Author: Andrea Fernández-Montoro, Daniel Angel-Velez, Camilla Benedetti, Nima Azari-Dolatabad, Osvaldo Bogado Pascottini, Ann Van Soom, and Krishna Chaitanya Pavani
Subjects: oocyte, in vitro maturation, culture systems, assisted reproduction technologies, bovine, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract: In vivo-matured oocytes exhibit higher developmental competence than those matured in vitro but mimicking the in vivo environment by in vitro conditions has been challenging. Until now, conventional two-dimensional (2D) systems have been used for in vitro maturation of bovine cumulus-oocytes-complexes (COCs). However, using such systems present certain limitations. Therefore, alternative low-cost methodologies may help to optimize oocyte in vitro maturation. Here, we used two different systems to culture COCs and evaluate their potential influence on embryo development and quality. In the first system, we used treated fumed silica particles to create a 3D microenvironment (liquid marbles; LM) to mature COCs. In the second system, we cultured COCs in 96-well plates with different dimensions (flat, ultra-low attachment round-bottom, and v-shaped 96-well plates). In both systems, the nuclear maturation rate remained similar to the control in 2D, showing that most oocytes reached metaphase II. However, the subsequent blastocyst rate remained lower in the liquid marble system compared with the 96-well plates and control 2D systems. Interestingly, a lower total cell number was found in the resulting embryos from both systems (LM and 96-well plates) compared with the control. In conclusion, oocytes matured in liquid marbles or 96-well plates showed no remarkable change in terms of meiotic resumption. None of the surface geometries influenced embryo development while oocyte maturation in liquid marbles led to reduced embryo development. These findings show that different geometry during maturation did not have a large impact on oocyte and embryo development. Lower embryo production after in vitro maturation in liquid marbles was probably detected because in vitro maturation was performed in serum-free medium, which makes oocytes more sensitive to possible toxic effects from the environment.
Published: 2023
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110. Postmortem Collection of Gametes for the Conservation of Endangered Mammals: A Review of the Current State-of-the-Art

Author: Tim E. R. G. Huijsmans, Hiba Ali Hassan, Katrien Smits, and Ann Van Soom
Subjects: gametes, postmortem, artificial reproduction techniques, conservation, genetic resource baking, oocytes, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract: The collection of gametes from recently deceased domestic and wildlife mammals has been well documented in the literature. Through the utilization of gametes recovered postmortem, scientists have successfully produced embryos in 10 different wildlife species, while in 2 of those, offspring have also been born. Thus, the collection of gametes from recently deceased animals represents a valuable opportunity to increase genetic resource banks, obviating the requirement for invasive procedures. Despite the development of several protocols for gamete collection, the refinement of these techniques and the establishment of species–specific protocols are still required, taking into account both the limitations and the opportunities. In the case of wildlife, the optimization of such protocols is impeded by the scarcity of available animals, many of which have a high genetic value that must be protected rather than utilized for research purposes. Therefore, optimizing protocols for wildlife species by using domestic species as a model is crucial. In this review, we focused on the current advancements in the collection, preservation, and utilization of gametes, postmortem, in selected species belonging to Equidae, Bovidae, and Felidae, both domestic and wildlife.
Published: 2023
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111. Transcriptomics Reveal Molecular Differences in Equine Oocytes Vitrified before and after In Vitro Maturation

Author: Daniel Angel-Velez, Tim Meese, Mohamed Hedia, Andrea Fernandez-Montoro, Tine De Coster, Osvaldo Bogado Pascottini, Filip Van Nieuwerburgh, Jan Govaere, Ann Van Soom, Krishna Pavani, and Katrien Smits
Subjects: cryopreservation, horse oocyte, RNA sequencing, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract: In the last decade, in vitro embryo production in horses has become an established clinical practice, but blastocyst rates from vitrified equine oocytes remain low. Cryopreservation impairs the oocyte developmental potential, which may be reflected in the messenger RNA (mRNA) profile. Therefore, this study aimed to compare the transcriptome profiles of metaphase II equine oocytes vitrified before and after in vitro maturation. To do so, three groups were analyzed with RNA sequencing: (1) fresh in vitro matured oocytes as a control (FR), (2) oocytes vitrified after in vitro maturation (VMAT), and (3) oocytes vitrified immature, warmed, and in vitro matured (VIM). In comparison with fresh oocytes, VIM resulted in 46 differentially expressed (DE) genes (14 upregulated and 32 downregulated), while VMAT showed 36 DE genes (18 in each category). A comparison of VIM vs. VMAT resulted in 44 DE genes (20 upregulated and 24 downregulated). Pathway analyses highlighted cytoskeleton, spindle formation, and calcium and cation ion transport and homeostasis as the main affected pathways in vitrified oocytes. The vitrification of in vitro matured oocytes presented subtle advantages in terms of the mRNA profile over the vitrification of immature oocytes. Therefore, this study provides a new perspective for understanding the impact of vitrification on equine oocytes and can be the basis for further improvements in the efficiency of equine oocyte vitrification.
Published: 2023
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112. Development of a Microfluidic Chip Powered by EWOD for In Vitro Manipulation of Bovine Embryos

Author: Adriana Karcz, Ann Van Soom, Katrien Smits, Sandra Van Vlierberghe, Rik Verplancke, Osvaldo Bogado Pascottini, Etienne Van den Abbeel, and Jan Vanfleteren
Subjects: digital microfluidics, electrowetting on dielectric, cell manipulation, individual embryo culture, lab-on-a-chip, Biotechnology, TP248.13-248.65
Abstract: Digital microfluidics (DMF) holds great potential for the alleviation of laboratory procedures in assisted reproductive technologies (ARTs). The electrowetting on dielectric (EWOD) technology provides dynamic culture conditions in vitro that may better mimic the natural embryo microenvironment. Thus far, EWOD microdevices have been proposed for in vitro gamete and embryo handling in mice and for analyzing the human embryo secretome. This article presents the development of the first microfluidic chip utilizing EWOD technology designed for the manipulation of bovine embryos in vitro. The prototype sustains the cell cycles of embryos manipulated individually on the chips during in vitro culture (IVC). Challenges related to the chip fabrication as well as to its application during bovine embryo IVC in accordance with the adapted on-chip protocol are thoroughly discussed, and future directions for DMF in ARTs are indicated.
Published: 2023
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113. Cathepsin-L Secreted by High-Quality Bovine Embryos Exerts an Embryotrophic Effect In Vitro

Author: Annelies Raes, Eline Wydooghe, Krishna Chaitanya Pavani, Osvaldo Bogado Pascottini, Katleen Van Steendam, Maarten Dhaenens, Annekatrien Boel, Sonia Heras, Björn Heindryckx, Luc Peelman, Dieter Deforce, Filip Van Nieuwerburgh, Geert Opsomer, Ann Van Soom, and Katrien Smits
Subjects: in vitro culture, embryonic development, embryotrophins, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract: While human in vitro embryo production is generally performed individually, animal models have shown that culturing embryos in groups improves blastocyst yield and quality. Paracrine embryotrophins could be responsible for this improved embryo development, but their identity remains largely unknown. We hypothesize that supplementation of embryotrophic proteins to a culture medium could be the key to improve individual embryo production. In this study, proteomics screening of culture media conditioned by bovine embryos revealed cathepsin-L as being secreted by both excellent- and good-quality embryos, while being absent in the medium conditioned by poor-quality embryos. The embryotrophic role of cathepsin-L was explored in vitro, whereby bovine zygotes were cultured individually for 8 days with or without cathepsin-L. Preliminary dose–response experiments pointed out 100 ng/mL as the optimal concentration of cathepsin-L in embryo culture medium. Supplementation of cathepsin-L to individual culture systems significantly improved blastocyst development and quality in terms of blastocoel formation at day 7, and the hatching ratio and apoptotic cell ratio at day 8, compared to the control. Taken together, cathepsin-L acts as an important embryotrophin by increasing embryo quality, and regulating blastulation and hatching in bovine in vitro embryo production.
Published: 2023
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114. Influence of seasonal differences on semen quality and subsequent embryo development of Belgian Blue bulls

Author: Seifi-Jamadi, Afshin, Zhandi, Mahdi, Kohram, Hamid, Luceño, Núria Llamas, Leemans, Bart, Henrotte, Emilie, Latour, Catherine, Demeyere, Kristel, Meyer, Evelyne, and Van Soom, Ann
Published: 2020
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115. Isolation and HPLC assisted quantification of two iridoid glycoside compounds and molecular DNA fingerprinting in critically endangered medicinal Picrorhiza kurroa Royle ex Benth: implications for conservation

Author: Kumar, Avinash, Rajpal, Vijay Rani, Ambika, Devarumath, Rachayya Mallikarjun, Kumari, Amita, Thakur, Rakesh, Chaudhary, Manju, Singh, Pradeep Pratap, Chauhan, Shiv Murat Singh, and Raina, Soom Nath
Published: 2021
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116. Expression profile and gap-junctional transfer of microRNAs in the bovine cumulus-oocyte complex.

Author: Six, R., Benedetti, C., Fan, Y., Guan, X., Gansemans, Y., Hedia, Mohamed, Pascottini, O. Bogado, Pavani, K. C., Nieuwerburgh, F. Van, Deforce, D., Smits, K., Soom, A. Van, and Peelman, L.
Subjects: GENE expression, NON-coding RNA, MICRORNA, BOS, OVUM
Abstract: MicroRNAs (miRNA) are important regulators of oocyte maturation, playing a key role in modulating gene expression both in a temporal- and spatial-specific manner. These small non-coding RNAs are involved in important processes during oocyte maturation, acting as messengers between the oocyte and its surrounding cumulus cells. Despite its significance, the bidirectional communication mechanism is still unknown. To test miRNA communication between oocyte and surrounding cumulus cells through the gap junctions the gap junctions were either blocked with carbenoxolone or not. MiRNA sequencing of oocytes at 1, 6, and 22 h of in vitro maturation was then performed. Among the differentially expressed miRNAs, bta-miR-21-5p, a regulator of cumulus cell viability and oocyte maturation, was the only previously known miRNA. Furthermore, by labeling a bta-miR-21-5p mimic with FAM, crossing of this miRNA through the gap junctions within the cumulus-oocyte complex could be visualized and internalization in the oocyte was confirmed by RT-qPCR. In conclusion, this study provides, for the first time, evidence that miRNA communication within the bovine cumulus-oocyte complex is enabled through the gap junctional network. [ABSTRACT FROM AUTHOR]
Published: 2024
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117. Random Amplification Polymorphic DNA and Agro-Morphological Traits-Based Fingerprinting for Detection of Genetic Divergence in Indian Black Rice.

Author: Sharma, Manisha, Raturi, Dhananjay, Rajpal, Vijay Rani, Chaudhary, Manju, Raina, Soom Nath, and Singh, Apekshita
Subjects: RAPD technique, RICE
Published: 2024
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118. Learning Shape Representation on Sparse Point Clouds for Volumetric Image Segmentation.

Author: Fabian Balsiger, Yannick Soom, Olivier Scheidegger, and Mauricio Reyes 0001
Published: 2019
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119. Fault sealing and caprock integrity for CO2 storage: an in situ injection experiment

Author: A. Zappone, A. P. Rinaldi, M. Grab, Q. C. Wenning, C. Roques, C. Madonna, A. C. Obermann, S. M. Bernasconi, M. S. Brennwald, R. Kipfer, F. Soom, P. Cook, Y. Guglielmi, C. Nussbaum, D. Giardini, M. Mazzotti, and S. Wiemer
Subjects: Geology, QE1-996.5, Stratigraphy, QE640-699
Abstract: The success of geological carbon storage depends on the assurance of permanent containment for injected carbon dioxide (CO2) in the storage formation at depth. One of the critical elements of the safekeeping of CO2 is the sealing capacity of the caprock overlying the storage formation despite faults and/or fractures, which may occur in it. In this work, we present an ongoing injection experiment performed in a fault hosted in clay at the Mont Terri underground rock laboratory (NW Switzerland). The experiment aims to improve our understanding of the main physical and chemical mechanisms controlling (i) the migration of CO2 through a fault damage zone, (ii) the interaction of the CO2 with the neighboring intact rock, and (iii) the impact of the injection on the transmissivity in the fault. To this end, we inject CO2-saturated saline water in the top of a 3 m thick fault in the Opalinus Clay, a clay formation that is a good analog of common caprock for CO2 storage at depth. The mobility of the CO2 within the fault is studied at the decameter scale by using a comprehensive monitoring system. Our experiment aims to close the knowledge gap between laboratory and reservoir scales. Therefore, an important aspect of the experiment is the decameter scale and the prolonged duration of observations over many months. We collect observations and data from a wide range of monitoring systems, such as a seismic network, pressure temperature and electrical conductivity sensors, fiber optics, extensometers, and an in situ mass spectrometer for dissolved gas monitoring. The observations are complemented by laboratory data on collected fluids and rock samples. Here we show the details of the experimental concept and installed instrumentation, as well as the first results of the preliminary characterization. An analysis of borehole logging allows for identifying potential hydraulic transmissive structures within the fault zone. A preliminary analysis of the injection tests helped estimate the transmissivity of such structures within the fault zone and the pressure required to mechanically open such features. The preliminary tests did not record any induced microseismic events. Active seismic tomography enabled sharp imaging the fault zone.
Published: 2021
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120. Practical methods to assess the effects of heat stress on the quality of frozen-thawed Belgian Blue semen in field conditions

Author: Residiwati, Gretania, Tuska, Habib S.A., Budiono, Kawai, Giulia K.V., Seifi-Jamadi, Afshin, Santoro, Davide, Leemans, Bart, Boccart, Christophe, Pascottini, Osvaldo Bogado, Opsomer, Geert, and Van Soom, Ann
Published: 2020
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121. Crossbreeding effect of double-muscled cattle on in vitro embryo development and quality

Author: Residiwati, Gretania, Tuska, Habib S.A., Dolatabad, Nima-Azari, Sidi, Shehu, Van Damme, Petra, Pavani, Krishna C., Pascottini, Osvaldo Bogado, Opsomer, Geert, and Van Soom, Ann
Published: 2020
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122. Exposing dairy bulls to high temperature-humidity index during spermatogenesis compromises subsequent embryo development in vitro

Author: Llamas Luceño, Núria, de Souza Ramos Angrimani, Daniel, de Cássia Bicudo, Luana, Szymańska, Katarzyna J., Van Poucke, Mario, Demeyere, Kristel, Meyer, Evelyne, Peelman, Luc, Mullaart, Erik, Broekhuijse, Marleen L.W.J., and Van Soom, Ann
Published: 2020
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123. Phytochemicals for Human Health: The Emerging Trends and Prospects

Author: Koul, Hari K, primary, Rajpal, Vijay Rani, additional, Sampath Kumar, Halmuthur. M., additional, Raina, Soom Nath, additional, and Qazi, G. N., additional
Published: 2024
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124. Microbiological Assessment of Car Doors and Steering Wheels at Benue State University, Makurdi: Public Health Implications

Author: Akinnibosun, Olajide, primary, Adikwu, Peter, additional, Sunday David, Onyemowo, additional, Emmanuel Oyiwona, Godwin, additional, Igomu Adole, Paul, additional, Yandev, Doowuese, additional, Agbo Oche, Dominic, additional, Ameh Agbo, Augustine, additional, Onyemowo Ochekpe, Sonia, additional, Enyanwu Okoh, Martina, additional, Terser Soom, Solomon, additional, and Ojochide Hassan, Amina, additional
Published: 2024
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125. Pronuclear transfer rescues poor embryo development of in vitro-grown secondary mouse follicles

Author: Christodoulaki, Antonia, primary, He, Haitang, additional, Zhou, Min, additional, De Roo, Chloë, additional, Baetens, Machteld, additional, De Pretre, Tine, additional, Fakhar-I-Adil, Muhammad, additional, Menten, Björn, additional, Van Soom, Ann, additional, Stoop, Dominic, additional, Boel, Annekatrien, additional, and Heindryckx, Björn, additional
Published: 2024
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126. The "zorgkassen": a unique access point to social health insurance in Flanders

Author: Van Gasse, Jo, primary, Senesael Dhaeyere, Eline, additional, Van Soom, Lieselotte, additional, and Pauwelyn, Koenraad, additional
Published: 2023
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127. Modulation of terpenoid indole alkaloid pathway via elicitation with phytosynthesized silver nanoparticles for the enhancement of ajmalicine, a pharmaceutically important alkaloid

Author: Verma, Sachin Kumar, primary, Goyary, Danswrang, additional, Singh, Amit Kumar, additional, Anandhan, Sivalingam, additional, Raina, Soom Nath, additional, Pandey, Sadanand, additional, Kumar, Shailesh, additional, and Khare, Neeraj, additional
Published: 2023
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128. 66 Developmental potential of single blastomeres within individual embryos presenting bipolar or multipolar divisions

Author: Fernández-Montoro, A., primary, De Coster, T., additional, Angel-Velez, D., additional, Zhao, Y., additional, Smits, K., additional, Vermeesch, J. R., additional, and Van Soom, A., additional
Published: 2023
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129. MicroRNA-146b negatively affects bovine embryo development and quality

Author: Pavani, Krishna Chaitanya, primary, XueFeng, Guan, additional, Chunduru, Jayendra, additional, Meese, Tim, additional, Peelman, Luc J., additional, Van Nieuwerburgh, Filip, additional, Deforce, Dieter, additional, Hendrix, An, additional, Tilleman, Kelly, additional, Van Soom, Ann, additional, and Smits, Katrien, additional
Published: 2023
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130. Structural health monitoring and the accuracy of different monitoring period for ageing fixed offshore platform in Malaysian water.

Author: Zulkifli, Muhammad Aniq Razin, Husain, Mohd Khairi Abu, Zaki, Noor Irza Mohd, Mukhlas, Nurul 'Azizah, Soom, Ezanizam Mat, Azman, Nurul Uyun, and Dzulkifli, Nur Fatin Maisarah
Subjects: STRUCTURAL health monitoring, ENERGY industries, FAST Fourier transforms, RELIABILITY in engineering, OFFSHORE structures, ACOUSTIC emission testing
Abstract: The oil and gas industry began in Malaysia in the early 1900s and has evolved over 115 years. Since 1990, Malaysia's gasoline consumption has increased at an annual rate of 7.2 per cent, reaching 44.9 Mtoe in 2008. The expected demands of oil and gas are increasing from 2010 until 2026. However, the energy sector, specifically in oil and gas, faces challenges as the resources have been declining in recent years. The oil and gas operators are pressured to improve their recovery of oil and gas resources hence needs to extend the operation of the platform beyond its design life. In order to do that, reliability engineering has become a common practice in the Malaysian oil and gas industry to access the integrity and requalification of offshore platforms in the late 1990s. However, accidents involving maritime structures has been occurring for a long time. For example, the MS Estonia involved 852 fatalities in 1994, whereas the Ranger I reported 84 fatalities in 1970 (Gulf of Mexico Jack-Up), and the Alexander Kielland semisubmersible reported 123 fatalities in 1980 (North Sea). The standard design life of the fixed offshore structure ranges between 20-30 years. In 2019, PETRONAS operated over 200 fixed offshore structures in Malaysian waters, which over half of them have outlived their design lives. Various standards and guidelines are introduced globally to ensure the extended lifetime of the fixed offshore platforms are safe to be used. However, the current development of structural health monitoring focuses on developing the technology, and only limited guidelines and standards discuss the optimum or recommended duration for the monitoring. Therefore, this study aims to determine the optimum monitoring period for deploying structural health systems at the fixed offshore platform. In this study, structural health monitoring (SHM) and wave radar system are used to collect data for the acceleration of the platform and the wave height hitting the platform. The data is then converted using Fast Fourier Transform to convert the time domain signal into a frequency-domain signal. The output is then used to investigate the impacts of different SHM duration assessments on the accuracy of the results hence determining the most optimum duration for the SHM assessment period. [ABSTRACT FROM AUTHOR]
Published: 2024
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131. A new online database on genome-related information of Indian plants

Author: Jha, Sumita, Raina, Soom N., Ohri, Deepak, Verma, Rakesh C., Dhar, Manoj K., Lekhak, Manoj M., Yadav, Shrirang R., Mahadev, Nandita, and Satyawada, Rama R.
Published: 2019

132. At-risk at the gate : prediction of study success of first-year science and engineering students in an open-admission university in Flanders—any incremental validity of study strategies?

Author: Pinxten, Maarten, Van Soom, Carolien, Peeters, Christine, De Laet, Tinne, and Langie, Greet
Published: 2019

133. Intersections between Ageing and Migration: Current Trends and Challenges

Author: Ciobanu Ruxandra Oana, Nedelcu Mihaela, Ammann Eva Soom, and van Holten Karin
Subjects: Sociology (General), HM401-1281
Published: 2020
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134. Does finasteride treatment for benign prostatic hyperplasia influence sperm DNA integrity in dogs?

Author: Daniel S. R. Angrimani, Luana C. Bicudo, Nuria Llamas Luceño, Bruno R. Rui, Matheus F. Silva, João D. A. Losano, Bart Leemans, Ann Van Soom, and Camila I. Vannucchi
Subjects: Prostate, Canine, DNA fragmentation, Sperm, Finasteride, Medicine (General), R5-920
Abstract: Résumé Contexte L’hyperplasie bénigne de la prostate (HBP) est l’un des troubles de la reproduction les plus courants chez le chien et chez l’homme. Le finastéride, un inhibiteur synthétique de l’enzyme 5α-réductase, est largement utilisé comme traitement médical. Bien que le sperme puisse être affecté à la fois par l’HBP et par le traitement avec le finastéride, l’influence directe sur l’intégrité de l’ADN reste peu claire. Le but de cette étude était ainsi de vérifier l’effet direct de l’HBP et/ou du traitement par finastéride sur l’intégrité de l’ADN des spermatozoïdes de chien. Dans la présente étude, 20 chiens mâles ont été randomisés selon un plan factoriel en 2x2 à l’un des 4 groupes expérimentaux suivants : Groupe HBP (n=5), Groupe HBP-Finastéride (n=5), Groupe non-HBP traité par Finastéride (n=5), et Groupe non-HBP non traité (n=5). L’analyse Le sperme a été réalisée mensuellement pendant 60 jours (J0, J30 et J60) soit après le début du traitement par finastéride ou à partir du diagnostic de HBP. L’intégrité de l’ADN des spermatozoïdes a été analysée par l’évaluation de la susceptibilité à la fragmentation (coloration au bleu de toluidine ; détermination de la structure de la chromatine des spermatozoïdes - SCSA), par l’évaluation directe de la fragmentation de l’ADN des spermatozoïdes (détermination de la dispersion de la chromatine des spermatozoïdes - SCDA) et par l’évaluation de la protamination des spermatozoïdes (chromomycine A3). Résultats L’intégrité de l’ADN des spermatozoïdes n’a pas été affectée par le traitement par finastéride. Cependant, les chiens avec HBP ont une susceptibilité plus élevée à la dénaturation acide de l’ADN des spermatozoïdes (SCSA) par comparaison aux chiens ne présentant pas d’HBP, ainsi qu’un pourcentage plus bas de spermatozoïdes avec intégrité de l’ADN (coloration au bleu de toluidine). Conclusions L’hyperplasie bénigne de la prostate induit des altérations de l’ADN des spermatozoïdes, alors que le traitement par finastéride n’influence pas directement par lui-même l’intégrité de l’ADN des spermatozoïdes.
Published: 2020
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135. The effect of season of birth on the morphometrics of newborn Belgian Blue calves

Author: Tuska, Habib Syaiful Arif, Residiwati, Gretania, Van Eetvelde, Mieke, Verdru, Karel, Meesters, Maya, Budiono, Pascottini, Osvaldo Bogado, Van Soom, Ann, and Opsomer, Geert
Published: 2022
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136. Induction and evaluation of colchitetraploids of two species of Tinospora Miers, 1851

Author: Rakesh Kr. Thakur, Vijay Rani Rajpal, Satyawada Rama Rao, Apekshita Singh, Lata Joshi, Pankaj Kaushal, and Soom Nath Raina
Subjects: Genetics, QH426-470
Abstract: Autotetraploidy, both natural and/or induced, has potential for genetic improvement of various crop species including that of medicinal importance. Tinospora cordifolia (Willdenow, 1806) Miers, 1851 ex Hooker et Thomson, 1855 and T. sinensis (Loureiro, 1790) Merrill, 1934 are two diploid species, which are dioecious, deciduous and climbing shrubs with high medicinal importance. Among the three methods used for induction of polyploidy by colchicine treatment, it was cotton swab method which successfully induced the polyploidy in both species. The morphological and cytogenetical features of the synthetic tetraploids were compared with their diploid counterparts. The tetraploids were morphologically distinct from diploid plants. They exhibited larger organs, such as stem, leaves, inflorescence, fruits, flowers and seeds. The tetraploids were characterized by the presence of low quadrivalent frequency and high bivalent average. Unequal distribution of chromosomes at anaphase I was found in 60% cells. The present study provides important information on the superiority of autotetraploids as compared to diploid counterparts in both species.
Published: 2020
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137. Understanding the relative importance of vertical and horizontal flow in ice-wedge polygons

Author: N. A. Wales, J. D. Gomez-Velez, B. D. Newman, C. J. Wilson, B. Dafflon, T. J. Kneafsey, F. Soom, and S. D. Wullschleger
Subjects: Technology, Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350
Abstract: Ice-wedge polygons are common Arctic landforms. The future of these landforms in a warming climate depends on the bidirectional feedback between the rate of ice-wedge degradation and changes in hydrological characteristics. This work aims to better understand the relative roles of vertical and horizontal water fluxes in the subsurface of polygonal landscapes, providing new insights and data to test and calibrate hydrological models. Field-scale investigations were conducted at an intensively instrumented location on the Barrow Environmental Observatory (BEO) near Utqiaġvik, AK, USA. Using a conservative tracer, we examined controls of microtopography and the frost table on subsurface flow and transport within a low-centered and a high-centered polygon. Bromide tracer was applied at both polygons in July 2015 and transport was monitored through two thaw seasons. Sampler arrays placed in polygon centers, rims, and troughs were used to monitor tracer concentrations. In both polygons, the tracer first infiltrated vertically until encountering the frost table and was then transported horizontally. Horizontal flow occurred in more locations and at higher velocities in the low-centered polygon than in the high-centered polygon. Preferential flow, influenced by frost table topography, was significant between polygon centers and troughs. Estimates of horizontal hydraulic conductivity were within the range of previous estimates of vertical conductivity, highlighting the importance of horizontal flow in these systems. This work forms a basis for understanding complexity of flow in polygonal landscapes.
Published: 2020
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138. Insight into the Boron Toxicity Stress-Responsive Genes in Boron-Tolerant Triticum dicoccum Shoots Using RNA Sequencing

Author: Mohd. Kamran Khan, Anamika Pandey, Mehmet Hamurcu, Vijay Rani Rajpal, Tomas Vyhnanek, Ali Topal, Soom Nath Raina, and Sait Gezgin
Subjects: abiotic stress, boron toxicity, emmer, expression profiling, genetic resources, neglected species, Agriculture
Abstract: Wheat production losses due to boron (B) toxicity can be reduced by breeding and growing modern wheat cultivars with a greater tolerance to high B. However, breeding of tolerant genotypes is possible by identifying B-tolerant wheat genetic resources and understanding their underlying molecular mechanism. Triticum dicoccum, despite being one of the oldest cultivated wheat species, mostly remained neglected and has been less explored for its potential towards abiotic stresses. In this study, for the first time, we report a B-toxicity-tolerant T. dicoccum genotype, PI94655, and its transcriptomic response towards high-B treatment (10 mM B) using RNA sequencing and RT-qPCR. More than 450 genes were significantly differentially expressed in the shoots of PI94655 under high B. A total 3237 novel genes and 12,206 novel transcripts were determined in the study. AP2-EREBP, MYB, and C3H were the families with the highest percentages of differentially expressed transcription factors (TFs) under B toxicity. Interestingly, KEGG pathway photosynthesis–antenna proteins showed the most significant enrichment. The obtained results suggested potential candidate genes that can be focused on to improve wheat tolerance to high B in future breeding programs. These genes can be functionally characterized to elucidate their role in providing tolerance to high B.
Published: 2023
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139. Beta-lactamase production and conjugative ability of multidrug resistant Salmonella Typhi in Southern Benue, Nigeria

Author: Peter Adikwu, Ebele Uchenna Umeh, Innocent Okonkwo Ogbonna, Iheukwumere Charles Chidozie, Godwin Attah Obande, Martina Enyanwu Okoh, Godwin Emmanuel Oyiwona, and Solomon Terser Soom
Subjects: salmonella typhi, antimicrobial resistance, plasmid, multidrug resistance, extended spectrum beta-lactamase, Infectious and parasitic diseases, RC109-216
Abstract: Objective: To examine multidrug resistant (MDR) Salmonella (S.) Typhi isolates obtained from the stool samples of patients attending secondary health centers in Southern Benue, Nigeria, for extended spectrum beta-lactamase (ESBL) production and conjugative ability. Methods: The double disc synergy test was used to screen for ESBL production in MDR isolates. The ability of S. Typhi to transfer resistance gene was determined by conjugation experiments using standard protocols, with slight modifications. Escherichia (E.) coli ATCC 25922 was used as the recipient organism. Result: The donor S. Typhi isolates showed resistance to all the classes of antibiotics except aminoglycosides and carbapenems. All isolates except TKP 106, APA 55, APA 78 and OGB 106 were positive for ESBL production. Reduction in the zones of inhibition of E. coli after incubation with S. Typhi showed evidence of conjugation and transfer of antibiotic resistance from S. Typhi to E. coli. Conclusions: The presence of ESBL-producing S. Typhi capable of conjugation poses a significant risk to the treatment and management of typhoid fever, which highlights the need for the regulation of antibiotic use through relevant policies and strategies that aim at halting the spread of MDR and ESBL-producing S. Typhi in such rural settings.
Published: 2023
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140. Functional Uses of Peanut (Arachis hypogaea L.) Seed Storage Proteins

Author: Singh, Apekshita, primary, Nath Raina, Soom, additional, Sharma, Manisha, additional, Chaudhary, Manju, additional, Sharma, Suman, additional, and Rani Rajpal, Vijay, additional
Published: 2021
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141. Neurological manifestations of COVID-19 in adults and children

Author: Cho, S, White, N, Premraj, L, Battaglini, D, Fanning, J, Suen, J, Bassi, G, Fraser, J, Robba, C, Griffee, M, Singh, B, Citarella, B, Merson, L, Solomon, T, Thomson, D, Abbas, A, Abdulkadir, N, Abe, R, Abel, L, Absil, L, Acharya, S, Acker, A, Adriao, D, Ageel, S, Ahmed, S, Ainscough, K, Aisa, T, Hssain, A, Tamlihat, Y, Akimoto, T, Akmal, E, Alalqam, R, Al-Dabbous, T, Alegesan, S, Alegre, C, Alex, B, Alexandre, K, Al-Fares, A, Alfoudri, H, Ali, I, Shah, N, Alidjnou, K, Aliudin, J, Alkhafajee, Q, Allavena, C, Allou, N, Altaf, A, Alves, J, Alves, R, Amaral, M, Amira, N, Ampaw, P, Andini, R, Andrejak, C, Angheben, A, Angoulvant, F, Ansart, S, Anthonidass, S, Antonelli, M, Brito, C, Apriyana, A, Aragao, I, Arancibia, F, Araujo, C, Arcadipane, A, Archambault, P, Arenz, L, Arlet, J, Arnold-Day, C, Arora, L, Arora, R, Artaud-Macari, E, Aryal, D, Asensio, A, Ashraf, M, Asif, N, Asim, M, Assie, J, Asyraf, A, Atique, A, Attanyake, A, Auchabie, J, Aumaitre, H, Auvet, A, Azemar, L, Azoulay, C, Bach, B, Bachelet, D, Badr, C, Baig, N, Baillie, J, Bak, E, Bakakos, A, Bakar, N, Bal, A, Balakrishnan, M, Balan, V, Bani-Sadr, F, Barbalho, R, Barclay, W, Barnett, S, Barnikel, M, Barrelet, A, Barrigoto, C, Bartoli, M, Baruch, J, Basmaci, R, Basri, M, Bauer, J, Rincon, D, Beane, A, Bedossa, A, Bee, K, Begum, H, Behilill, S, Beishuizen, A, Beljantsev, A, Bellemare, D, Beltrame, A, Beluze, M, Benech, N, Benjiman, L, Benkerrou, D, Bennett, S, Bento, L, Berdal, J, Bergeaud, D, Bergin, H, Sobrino, J, Bertoli, G, Bertolino, L, Bessis, S, Bevilcaqua, S, Bezulier, K, Bhatt, A, Bhavsar, K, Bianco, C, Bidin, F, Singh, M, Kamarudin, M, Bissuel, F, Bitker, L, Bitton, J, Blanco-Schweizer, P, Blier, C, Bloos, F, Blot, M, Boccia, F, Bodenes, L, Bogaarts, A, Bogaert, D, Boivin, A, Bolze, P, Bompart, F, Borges, D, Borie, R, Bosse, H, Botelho-Nevers, E, Bouadma, L, Bouchaud, O, Bouchez, S, Bouhmani, D, Bouhour, D, Bouiller, K, Bouillet, L, Bouisse, C, Boureau, A, Bourke, J, Bouscambert, M, Bousquet, A, Bouziotis, J, Boxma, B, Boyer-Besseyre, M, Boylan, M, Bozza, F, Braconnier, A, Braga, C, Brandenburger, T, Monteiro, F, Brazzi, L, Breen, P, Breen, D, Breen, S, Brickell, K, Browne, S, Brozzi, N, Brusse-Keizer, M, Buchtele, N, Buesaquillo, C, Buisson, M, Burhan, E, Burrell, A, Bustos, I, Cabie, A, Cabral, S, Caceres, E, Cadoz, C, Calvache, J, Camoes, J, Campana, V, Campbell, P, Canepa, C, Cantero, M, Caraux-Paz, P, Carcel, S, Cardellino, C, Cardoso, S, Cardoso, F, Cardoso, N, Carelli, S, Carlier, N, Carmoi, T, Carney, G, Carqueja, I, Carret, M, Carrier, F, Carroll, I, Carson, G, Casanova, M, Cascao, M, Casey, S, Casimiro, J, Cassandra, B, Castaneda, S, Castanheira, N, Castor-Alexandre, G, Castrillon, H, Castro, I, Catarino, A, Catherine, F, Cattaneo, P, Cavalin, R, Cavalli, G, Cavayas, A, Cervantes-Gonzalez, M, Chair, A, Chakveatze, C, Chan, A, Chand, M, Auger, C, Chapplain, J, Chas, J, Chaudry, M, Iniguez, J, Chen, A, Chen, Y, Cheng, M, Cheret, A, Chiarabini, T, Chica, J, Chidambaram, S, Tho, L, Chirouze, C, Chiumello, D, Cholley, B, Chopin, M, Chow, T, Chua, H, Chua, J, Cidade, J, Herreros, J, Ciullo, A, Clarke, J, Clarke, E, Clohisey, S, Cobb, P, Codan, C, Cody, C, Coelho, A, Coles, M, Colin, G, Collins, M, Colombo, S, Combs, P, Connor, M, Conrad, A, Contreras, S, Conway, E, Cooke, G, Copland, M, Cordel, H, Corley, A, Cornelis, S, Cornet, A, Corpuz, A, Corvaisier, G, Costigan, E, Couffignal, C, Couffin-Cadiergues, S, Courtois, R, Cousse, S, Cregan, R, Croonen, S, Crowl, G, Crump, J, Cruz, C, Berm, J, Rojo, J, Csete, M, Cullen, A, Cummings, M, Curley, G, Curlier, E, Curran, C, Custodio, P, Filipe, A, Silveira, C, Dabaliz, A, Dagens, A, Dahly, D, Dalton, H, Dalton, J, Daly, S, Daneman, N, Daniel, C, Dankwa, E, Dantas, J, D'Aragon, F, Loughry, G, Montmollin, E, Franca, R, Oliveira, A, Rosa, R, Silva, T, Vries, P, Deacon, J, Dean, D, Debard, A, Debenedictis, B, Debray, M, Decastro, N, Dechert, W, Deconninck, L, Decours, R, Defous, E, Delacroix, I, Delaveuve, E, Delavigne, K, Delfos, N, Dell'Amore, A, Delmas, C, Delobel, P, Delsing, C, Demonchy, E, Denis, E, Deplanque, D, Depuydt, P, Desai, M, Descamps, D, Desvallees, M, Dewayanti, S, Diallo, A, Diamantis, S, Dias, A, Diaz, J, Diaz, P, Diaz, R, Didier, K, Diehl, J, Dieperink, W, Dimet, J, Dinot, V, Diop, F, Diouf, A, Dishon, Y, Djossou, F, Docherty, A, Doherty, H, Dondorp, A, Donnelly, M, Donnelly, C, Donohue, S, Donohue, Y, Donohue, C, Doran, P, Dorival, C, D'Ortenzio, E, Douglas, J, Dournon, N, Downer, T, Downey, J, Downing, M, Drake, T, Driscoll, A, Fonseca, C, Dubee, V, Dubos, F, Ducancelle, A, Duculan, T, Dudman, S, Dunand, P, Dunning, J, Duplaix, M, Durante-Mangoni, E, Iii, L, Dussol, B, Duthoit, J, Duval, X, Dyrhol-Riise, A, Ean, S, Echeverria-Villalobos, M, Egan, S, Eira, C, Sanharawi, M, Elapavaluru, S, Elharrar, B, Ellerbroek, J, Eloy, P, Elshazly, T, Enderle, I, Eng, C, Engelmann, I, Enouf, V, Epaulard, O, Escher, M, Esperatti, M, Esperou, H, Esposito-Farese, M, Estevao, J, Etienne, M, Ettalhaoui, N, Everding, A, Evers, M, Fabre, M, Fabre, I, Faheem, A, Fahy, A, Fairfield, C, Fareed, K, Faria, P, Farooq, A, Fateena, H, Fatoni, A, Faure, K, Favory, R, Fayed, M, Feely, N, Feeney, L, Fernandes, J, Fernandes, M, Fernandes, S, Ferrand, F, Devouge, E, Ferrao, J, Ferraz, M, Ferreira, S, Ferreira, B, Ferrer-Roca, R, Ferriere, N, Ficko, C, Figueiredo-Mello, C, Fiorda, J, Flament, T, Flateau, C, Fletcher, T, Florio, L, Flynn, D, Foley, C, Foley, J, Fonseca, T, Fontela, P, Forsyth, S, Foster, D, Foti, G, Fourn, E, Fowler, R, Fraher, M, Franch-Llasat, D, Fraser, C, Freire, M, Ribeiro, A, Fritz, R, Fry, S, Fuentes, N, Fukuda, M, Gaborieau, V, Gaci, R, Gagliardi, M, Gagnard, J, Gagneux-Brunon, A, Gaiao, S, Skeie, L, Gallagher, P, Gamble, C, Gani, Y, Garan, A, Garcia, R, Barrio, N, Garcia-Gallo, E, Garot, D, Garrait, V, Gauli, B, Gault, N, Gavin, A, Gavrylov, A, Gaymard, A, Gebauer, J, Geraud, E, Morlaes, L, Germano, N, Ghosn, J, Giani, M, Gibson, J, Gigante, T, Gilg, M, Gilroy, E, Giordano, G, Girvan, M, Gissot, V, Glikman, D, Gnall, E, Goco, G, Goehringer, F, Goepel, S, Goffard, J, Goh, J, Golob, J, Gomez-Junyent, J, Gominet, M, Goncalves, B, Gonzalez, A, Gordon, P, Gorenne, I, Goubert, L, Goujard, C, Goulenok, T, Grable, M, Graf, J, Grandin, E, Granier, P, Grasselli, G, Green, C, Greene, C, Greenhalf, W, Greffe, S, Grieco, D, Griffiths, F, Grigoras, I, Groenendijk, A, Lordemann, A, Gruner, H, Gu, Y, Guedj, J, Guego, M, Guellec, D, Guerguerian, A, Guerreiro, D, Guery, R, Guillaumot, A, Guilleminault, L, Castro, M, Guimard, T, Haalboom, M, Haber, D, Habraken, H, Hachemi, A, Hadri, N, Haidash, O, Haidri, F, Hakak, S, Hall, A, Hall, M, Halpin, S, Hameed, J, Hamer, A, Hamidfar, R, Hammond, T, Han, L, Haniffa, R, Hao, K, Hardwick, H, Harrison, S, Harrison, E, Harrison, J, Hashmi, J, Hashmi, M, Hayat, M, Hayes, A, Hays, L, Heerman, J, Heggelund, L, Hendry, R, Hennessy, M, Henriquez-Trujillo, A, Hentzien, M, Hernandez-Montfort, J, 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Abstract: Different neurological manifestations of coronavirus disease 2019 (COVID-19) in adults and children and their impact have not been well characterized. We aimed to determine the prevalence of neurological manifestations and in-hospital complications among hospitalized COVID-19 patients and ascertain differences between adults and children. We conducted a prospective multicentre observational study using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) cohort across 1507 sites worldwide from 30 January 2020 to 25 May 2021. Analyses of neurological manifestations and neurological complications considered unadjusted prevalence estimates for predefined patient subgroups, and adjusted estimates as a function of patient age and time of hospitalization using generalized linear models. Overall, 161 239 patients (158 267 adults; 2972 children) hospitalized with COVID-19 and assessed for neurological manifestations and complications were included. In adults and children, the most frequent neurological manifestations at admission were fatigue (adults: 37.4%; children: 20.4%), altered consciousness (20.9%; 6.8%), myalgia (16.9%; 7.6%), dysgeusia (7.4%; 1.9%), anosmia (6.0%; 2.2%) and seizure (1.1%; 5.2%). In adults, the most frequent in-hospital neurological complications were stroke (1.5%), seizure (1%) and CNS infection (0.2%). Each occurred more frequently in intensive care unit (ICU) than in non-ICU patients. In children, seizure was the only neurological complication to occur more frequently in ICU versus non-ICU (7.1% versus 2.3%, P < 0.001). Stroke prevalence increased with increasing age, while CNS infection and seizure steadily decreased with age. There was a dramatic decrease in stroke over time during the pandemic. Hypertension, chronic neurological disease and the use of extracorporeal membrane oxygenation were associated with increased risk of stroke. Altered consciousness was associated with CNS infection, seizure and stroke.
Published: 2023

142. Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19

Author: Kartsonaki, C, Baillie, J, Barrio, N, Baruch, J, Beane, A, Blumberg, L, Bozza, F, Broadley, T, Burrell, A, Carson, G, Citarella, B, Dagens, A, Dankwa, E, Donnelly, C, Dunning, J, Elotmani, L, Escher, M, Farshait, N, Goffard, J, Goncalves, B, Hall, M, Hashmi, M, Heng, B, Ho, A, Jassat, W, Jimenez, M, Laouenan, C, Lissauer, S, Martin-Loeches, I, Mentre, F, Merson, L, Morton, B, Munblit, D, Nekliudov, N, Nichol, A, Oinam, B, Ong, D, Panda, P, Petrovic, M, Pritchard, M, Ramakrishnan, N, Ramos, G, Roger, C, Sandulescu, O, Semple, M, Sharma, P, Sigfrid, L, Somers, E, Streinu-Cercel, A, Taccone, F, Vecham, P, Vijayaraghavan, B, Wei, J, Wils, E, Wong, X, Horby, P, Rojek, A, Olliaro, P, Abbas, A, Abdukahil, S, Abdulkadir, N, Abe, R, Abel, L, Absil, L, Acharya, S, Acker, A, Adam, E, Adriao, D, Al Ageel, S, Ahmed, S, Ainscough, K, Airlangga, E, Aisa, T, Hssain, A, Tamlihat, Y, Akimoto, T, Akmal, E, Al Qasim, E, Alalqam, R, Alberti, A, Al-Dabbous, T, Alegesan, S, Alegre, C, Alessi, M, Alex, B, Alexandre, K, Al-Fares, A, Alfoudri, H, Ali, I, Ali, A, Shah, N, Alidjnou, K, Aliudin, J, Alkhafajee, Q, Allavena, C, Allou, N, Altaf, A, Alves, J, Alves, R, Amaral, M, Amira, N, Ampaw, P, Andini, R, Andrejak, C, Angheben, A, Angoulvant, F, Ansart, S, Anthonidass, S, Antonelli, M, Antunes De Brito, C, Apriyana, A, Arabi, Y, Aragao, I, Arancibia, F, Araujo, C, Arcadipane, A, Archambault, P, Arenz, L, Arlet, J, Arnold-Day, C, Arora, L, Arora, R, Artaud-Macari, E, Aryal, D, Asensio, A, Ashraf, M, Asif, N, Asim, M, Assie, J, Asyraf, A, Atique, A, Attanyake, A, Auchabie, J, Aumaitre, H, Auvet, A, Azemar, L, Azoulay, C, Bach, B, Bachelet, D, Badr, C, Baig, N, Baird, J, Bak, E, Bakakos, A, Bakar, N, Bal, A, Balakrishnan, M, Balan, V, Bani-Sadr, F, Barbalho, R, Barbosa, N, Barclay, W, Barnett, S, Barnikel, M, Barrasa, H, Barrelet, A, Barrigoto, C, Bartoli, M, Bashir, M, Basmaci, R, Basri, M, Battaglini, D, Bauer, J, Bautista Rincon, D, Bazan Dow, D, Bedossa, A, Bee, K, Begum, H, Behilill, S, Beishuizen, A, Beljantsev, A, Bellemare, D, Beltrame, A, Beltrao, B, Beluze, M, Benech, N, Benjiman, L, Benkerrou, D, Bennett, S, Bento, L, Berdal, J, Bergeaud, D, Bergin, H, Bernal Sobrino, J, Bertoli, G, Bertolino, L, Bessis, S, Bevilcaqua, S, Bezulier, K, Bhatt, A, Bhavsar, K, Bianco, C, Bidin, F, Bikram Singh, M, Bin Humaid, F, Bin Kamarudin, M, Bissuel, F, Biston, P, Bitker, L, Bitton, J, Blanco-Schweizer, P, Blier, C, Bloos, F, Blot, M, Boccia, F, Bodenes, L, Bogaarts, A, Bogaert, D, Boivin, A, Bolze, P, Bompart, F, Bonfasius, A, Borges, D, Borie, R, Bosse, H, Botelho-Nevers, E, Bouadma, L, Bouchaud, O, Bouchez, S, Bouhmani, D, Bouhour, D, Bouiller, K, Bouillet, L, Bouisse, C, Boureau, A, Bourke, J, Bouscambert, M, Bousquet, A, Bouziotis, J, Boxma, B, Boyer-Besseyre, M, Boylan, M, Braconnier, A, Braga, C, Brandenburger, T, Bras Monteiro, F, Brazzi, L, Breen, P, Breen, D, Brickell, K, Browne, S, Browne, A, Brozzi, N, Brusse-Keizer, M, Buchtele, N, Buesaquillo, C, Bugaeva, P, Buisson, M, Buonsenso, D, Burhan, E, Bustos, I, Butnaru, D, Cabie, A, Cabral, S, Caceres, E, Cadoz, C, Callahan, M, Calligy, K, Calvache, J, Camoes, J, Campana, V, Campbell, P, Campisi, J, Canepa, C, Cantero, M, Caraux-Paz, P, Carcel, S, Cardellino, C, Cardoso, S, Cardoso, F, Cardoso, N, Carelli, S, Carlier, N, Carmoi, T, Carney, G, Carqueja, I, Carret, M, Carrier, F, Carroll, I, Casanova, M, Cascao, M, Casey, S, Casimiro, J, Cassandra, B, Castaneda, S, Castanheira, N, Castor-Alexandre, G, Castrillon, H, Castro, I, Catarino, A, Catherine, F, Cattaneo, P, Cavalin, R, Cavalli, G, Cavayas, A, Ceccato, A, Cervantes-Gonzalez, M, Chair, A, Chakveatze, C, Chan, A, Chand, M, Chantalat Auger, C, Chapplain, J, Chas, J, Chatterjee, A, Chaudry, M, Chavez Iniguez, J, Chen, A, Chen, Y, Cheng, M, Cheret, A, Chiarabini, T, Chica, J, Chidambaram, S, Chin Tho, L, Chirouze, C, Chiumello, D, Cho, S, Cholley, B, Chopin, M, Chow, T, Chow, Y, Chua, H, Chua, J, Cidade, J, Cisneros Herreros, J, Ciullo, A, Clarke, J, Clarke, E, Granado, R, Clohisey, S, Cobb, P, Codan, C, Cody, C, Coelho, A, Coles, M, Colin, G, Collins, M, Colombo, S, Combs, P, Connor, M, Conrad, A, Contreras, S, Conway, E, Cooke, G, Copland, M, Cordel, H, Corley, A, Cornelis, S, Cornet, A, Corpuz, A, Cortegiani, A, Corvaisier, G, Costigan, E, Couffignal, C, Couffin-Cadiergues, S, Courtois, R, Cousse, S, Cregan, R, Crepy D'Orleans, C, Cristella, C, Croonen, S, Crowl, G, Crump, J, Cruz, C, Cruz Berm, J, Cruz Rojo, J, Csete, M, Cullen, A, Cummings, M, Curley, G, Curlier, E, Curran, C, Custodio, P, da Silva Filipe, A, Da Silveira, C, Dabaliz, A, Dahly, D, Dalton, H, Dalton, J, Daly, S, Daneman, N, Daniel, C, Dantas, J, D'Aragon, F, de Jong, M, de Loughry, G, de Mendoza, D, De Montmollin, E, de Oliveira Franca, R, de Pinho Oliveira, A, De Rosa, R, De Rose, C, de Silva, T, de Vries, P, Deacon, J, Dean, D, Debard, A, Debray, M, Decastro, N, Dechert, W, Deconninck, L, Decours, R, Defous, E, Delacroix, I, Delaveuve, E, Delavigne, K, Delfos, N, Deligiannis, I, Dell'Amore, A, Delmas, C, Delobel, P, Delsing, C, Demonchy, E, Denis, E, Deplanque, D, Depuydt, P, Desai, M, Descamps, D, Desvallees, M, Dewayanti, S, Dhanger, P, Diallo, A, Diamantis, S, Dias, A, Diaz, J, Diaz, P, Diaz, R, Didier, K, Diehl, J, Dieperink, W, Dimet, J, Dinot, V, Diop, F, Diouf, A, Dishon, Y, Djossou, F, Docherty, A, Doherty, H, Dondorp, A, Dong, A, Donnelly, M, Donohue, S, Donohue, Y, Donohue, C, Doran, P, Dorival, C, D'Ortenzio, E, Douglas, J, Douma, R, Dournon, N, Downer, T, Downey, J, Downing, M, Drake, T, Driscoll, A, Dryden, M, Duarte Fonseca, C, Dubee, V, Dubos, F, Ducancelle, A, Duculan, T, Dudman, S, Duggal, A, Dunand, P, Duplaix, M, Durante-Mangoni, E, Durham, L, Dussol, B, Duthoit, J, Duval, X, Dyrhol-Riise, A, Ean, S, Echeverria-Villalobos, M, Egan, S, Eira, C, El Sanharawi, M, Elapavaluru, S, Elharrar, B, Ellerbroek, J, Eloy, P, Elshazly, T, Elyazar, I, Enderle, I, Endo, T, Eng, C, Engelmann, I, Enouf, V, Epaulard, O, Esperatti, M, Esperou, H, Esposito-Farese, M, Estevao, J, Etienne, M, Ettalhaoui, N, Everding, A, Evers, M, Fabre, M, Fabre, I, Faheem, A, Fahy, A, Fairfield, C, Fakar, Z, Fareed, K, Faria, P, Farooq, A, Fateena, H, Fatoni, A, Faure, K, Favory, R, Fayed, M, Feely, N, Feeney, L, Fernandes, J, Fernandes, M, Fernandes, S, Ferrand, F, Devouge, E, Ferrao, J, Ferraz, M, Ferreira, S, Ferreira, I, Ferreira, B, Ferrer-Roca, R, Ferriere, N, Ficko, C, Figueiredo-Mello, C, Finlayson, W, Fiorda, J, Flament, T, Flateau, C, Fletcher, T, Florio, L, Flynn, D, Foley, C, Foley, J, Fomin, V, Fonseca, T, Fontela, P, Forsyth, S, Foster, D, Foti, G, Fourn, E, Fowler, R, Fraher, M, Franch-Llasat, D, Fraser, J, Fraser, C, Freire, M, Freitas Ribeiro, A, Friedrich, C, Fritz, R, Fry, S, Fuentes, N, Fukuda, M, Argin, G, Gaborieau, V, Gaci, R, Gagliardi, M, Gagnard, J, Gagneux-Brunon, A, Gaiao, S, Skeie, L, Gallagher, P, Gamble, C, Gani, Y, Garan, A, Garcia, R, Garcia-Diaz, J, Garcia-Gallo, E, Garimella, N, Garot, D, Garrait, V, Gauli, B, Gault, N, Gavin, A, Gavrylov, A, Gaymard, A, Gebauer, J, Geraud, E, Morlaes, L, Germano, N, Ghisulal, P, Ghosn, J, Giani, M, Gibson, J, Gigante, T, Gilg, M, Gilroy, E, Giordano, G, Girvan, M, Gissot, V, Glikman, D, Glybochko, P, Gnall, E, Goco, G, Goehringer, F, Goepel, S, Goh, J, Golob, J, Gomes, R, Gomez, K, Gomez-Junyent, J, Gominet, M, Gonzalez, A, Gordon, P, Gorenne, I, Goubert, L, Goujard, C, Goulenok, T, Grable, M, Graf, J, Grandin, E, Granier, P, Grasselli, G, Green, C, Greene, C, Greenhalf, W, Greffe, S, Grieco, D, Griffee, M, Griffiths, F, Grigoras, I, Groenendijk, A, Grosse Lordemann, A, Gruner, H, Gu, Y, Guedj, J, Guego, M, Guellec, D, Guerguerian, A, Guerreiro, D, Guery, R, Guillaumot, A, Guilleminault, L, Guimaraes de Castro, M, Guimard, T, Haalboom, M, Haber, D, Habraken, H, Hachemi, A, Hackmann, A, Hadri, N, Haidri, F, Hakak, S, Hall, A, Halpin, S, Hameed, J, Hamer, A, Hamers, R, Hamidfar, R, Hammond, T, Han, L, Haniffa, R, Hao, K, Hardwick, H, 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R., Kobbe R., Kodippily C., Kohns Vasconcelos M., Koirala S., Komatsu M., Kosgei C., Kpangon A., Krawczyk K., Krishnan V., Krishnan S., Kruglova O., Kumar D., Kumar G., Kumar M., Kuriakose D., Kurtzman E., Kutsogiannis D., Kutsyna G., Kyriakoulis K., Lachatre M., Lacoste M., Laffey J. G., Lagrange M., Laine F., Lairez O., Lakhey S., Lalueza A., Lambert M., Lamontagne F., Langelot-Richard M., Langlois V., Lantang E. Y., Lanza M., Laribi S., Lariviere D., Lasry S., Lath S., Latif N., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence T., Lawrence C., Le M., Le Bihan C., Le Bris C., Le Falher G., Le Fevre L., Le Hingrat Q., Le Marechal M., Mestre S., Le Moal G., Le Moing V., Le Nagard H., Le Turnier P., Leal E., Leal Santos M., Lee T. C., Lee J., Lee H. G., Lee B. H., Lee Y. L., Lee S. H., Leeming G., Lefebvre L., Lefebvre B., Lefevre B., LeGac S., Lelievre J. -D., Lellouche F., Lemaignen A., Lemee V., Lemeur A., Lemmink G., Lene H. 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S., Marino F., Marino D., Markowicz S., Maroun Eid C., Marques A., Marquis C., Marsh B., Marsh L., Marshal M., Marshall J., Martelli C. T., Martin D. -A., Martin E., Martin-Blondel G., Martinot M., Martin-Quiros A., Martins J., Martins A., Martins N., Martins Rego C., Martucci G., Martynenko O., Marwali E. M., Marzukie M., Maslove D., Mason S., Masood S., Mat Nor B., Matan M., Mathew M., Mathieu D., Mattei M., Matulevics R., Maulin L., Maxwell M., Maynar J., Mazzoni T., McEvoy N., McSweeney L., McArthur C., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McGeer A., McKay C., McKeown J., McLean K. A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Meher M., Mehkri O., Mele F., Melo L., Memon K., Mendes J. J., Menkiti O., Menon K., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Meta R., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miranda-Maldonado H., Misnan N. A., Mohamed T. J., Mohamed N. N. E., Moin A., Molina D., Molinos E., Molloy B., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Morales Cely L., Moro L., Motherway C., Motos A., Mouquet H., Mouton Perrot C., Moyet J., Mudara C., Mufti A. K., Muh N. Y., Muhamad D., Mullaert J., Muller F., Muller K. E., Muneeb S., Munir N., Munshi L., Murphy A., Murphy L., Murris M., Murthy S., Musaab H., Muvindi H., Muyandy G., Myrodia D. M., Mohd-Hanafiah F. N., Nagpal D., Nagrebetsky A., Narasimhan M., Narayanan N., Nasim Khan R., Nazerali-Maitland A., Neant N., Neb H., Nelwan E., Neto R., Neumann E., Ng P., Ng W. Y., Nghi A., Nguyen D., Ni Choileain O., Ni Leathlobhair N., Nitayavardhana P., Nonas S., Noordin N. A. M., Noret M., Norharizam N. F. I., Norman L., Notari A., Noursadeghi M., Nowicka K., Nowinski A., Nseir S., Nunez J. 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Abstract: Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world’s largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a ~30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who hav
Published: 2023

143. Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry

Author: Griffee, M, Bozza, P, Reyes, L, Eddington, D, Rosenberger, D, Merson, L, Citarella, B, Fanning, J, Alexander, P, Fraser, J, Dalton, H, Cho, S, Abdukahil, S, Abdulkadir, N, Abe, R, Abel, L, Abrous, A, Absil, L, Acker, A, Adam, E, Adriao, D, Al Ageel, S, Ahmed, S, Ainscough, K, Aisa, T, Hssain, A, Tamlihat, Y, Akimoto, T, Akmal, E, Akwani, C, Al Qasim, E, Alalqam, R, Alberti, A, Al-dabbous, T, Alegesan, S, Alessi, M, Alex, B, Alexandre, K, Al-Fares, A, Alfoudri, H, Ali, I, Alidjnou, K, Aliudin, J, Alkhafajee, Q, Allavena, C, Allou, N, Alves, J, Alves, R, Cabrita, J, Amaral, M, Amira, N, Ampaw, P, Andini, R, Andrejak, C, Angheben, A, Angoulvant, F, Ansart, S, Anthonidass, S, Antonelli, M, de Brito, C, Apriyana, A, Arabi, Y, Aragao, I, Arancibia, F, Araujo, C, Arcadipane, A, Archambault, P, Arenz, L, Arlet, J, Arnold-Day, C, Arora, L, Arora, R, Artaud-Macari, E, Aryal, D, Asensio, A, Ashraf, M, Assie, J, Asyraf, A, Atif, M, Atique, A, Auchabie, J, Aumaitre, H, Auvet, A, Azemar, L, Azoulay, C, Bach, B, Bachelet, D, Badr, C, Baig, N, Baillie, J, Bak, E, Bakakos, A, Bakar, N, Bal, A, Balakrishnan, M, Balan, V, Bani-Sadr, F, Barbalho, R, Barbosa, N, Barclay, W, Barnett, S, Barnikel, M, Barrasa, H, Barrelet, A, Barrigoto, C, Bartoli, M, Baruch, J, Basmaci, R, Basri, M, Battaglini, D, Bauer, J, Rincon, D, Beane, A, Bedossa, A, Hong Bee, K, Begum, H, Behilill, S, Beishuizen, A, Beljantsev, A, Bellemare, D, Beltrame, A, Beltrao, B, Beluze, M, Benech, N, Benjiman, L, Benkerrou, D, Bennett, S, Benny, B, Bento, L, Berdal, J, Bergeaud, D, Bergin, H, Sobrino, J, Bertoli, G, Bertolino, L, Bessis, S, Bevilcaqua, S, Bezulier, K, Bhatt, A, Bhavsar, K, Bianco, C, Bidin, F, Singh, M, Humaid, F, Kamarudin, M, Bisoffi, Z, Bissuel, F, Bitker, L, Bitton, J, Blanco-Schweizer, P, Blier, C, Bloos, F, Blot, M, Blumberg, L, Boccia, F, Bodenes, L, Bogaert, D, Boivin, A, Bolanos, I, Bolze, P, Bompart, F, Borges, D, Borie, R, Bosse, H, Botelho-Nevers, E, Bouadma, L, Bouchaud, O, Bouchez, S, Bouhmani, D, Bouhour, D, Bouiller, K, Bouillet, L, Bouisse, C, Boureau, A, Bourke, J, Bouscambert, M, Bousquet, A, Bouziotis, J, Boxma, B, Boyer-Besseyre, M, Boylan, M, Bozza, F, Braconnier, A, Braga, C, Brandenburger, T, Monteiro, F, Brazzi, L, Breen, P, Breen, D, Brewster, D, Brickell, K, Browne, S, Browne, A, Brozzi, N, Brusse-Keizer, M, Bryda, P, Buchtele, N, Buisson, M, Burhan, E, Burrell, A, Bustos, I, Cabie, A, Cabral, S, Caceres, E, Cadoz, C, Garces, R, Calligy, K, Calvache, J, Camoes, J, Campana, V, Campbell, P, Campisi, J, Canepa, C, Cantero, M, Caraux-Paz, P, Carcel, S, Cardellino, C, Cardoso, S, Cardoso, F, Cardoso, N, Carelli, S, Carlier, N, Carmoi, T, Carney, G, Carqueja, I, Carret, M, Carrier, F, Carroll, I, Carson, G, Casanova, M, Cascao, M, Casey, S, Casimiro, J, Cassandra, B, Castaneda, S, Castanheira, N, Castor-Alexandre, G, Castro, I, Catarino, A, Catherine, F, Cattaneo, P, Cavalin, R, Cavayas, A, Cervantes-Gonzalez, M, Chair, A, Chakveatze, C, Chan, A, Chand, M, 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Dantas, J, D'Aragon, F, de Jong, M, de Loughry, G, De Montmollin, E, de Oliveira Franca, R, de Pinho Oliveira, A, De Rosa, R, de Silva, T, de Vries, P, Dean, D, Debard, A, Debenedictis, B, Debray, M, Decastro, N, Dechert, W, Deconninck, L, Decours, R, Defous, E, Delacroix, I, Delaveuve, E, Delavigne, K, Delfos, N, Deligiannis, I, Dell'Amore, A, Delmas, C, Delobel, P, Delsing, C, Demonchy, E, Denis, E, Deplanque, D, Depuydt, P, Desai, M, Descamps, D, Desvallees, M, Dewayanti, S, Dhanger, P, Diallo, A, Diamantis, S, Dias, A, Da Silva, F, Diaz, J, Diaz, R, Diaz, P, Didier, K, Diehl, J, Dieperink, W, Dimet, J, Dinot, V, Diop, F, Diouf, A, Dishon, Y, Djossou, F, Docherty, A, Doherty, H, Donnelly, M, Donnelly, C, Donohue, S, Donohue, Y, Donohue, C, Doran, P, Dorival, C, D'Ortenzio, E, Douglas, J, Dournon, N, Downer, T, Downey, J, Downing, M, Drake, T, Driscoll, A, Dryden, M, Fonseca, C, Dubee, V, Dubos, F, Ducancelle, A, Duculan, T, Dudman, S, Duggal, A, Dunand, P, Dunning, J, Duplaix, M, 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B., Matan M., Mathieu D., Mattei M., Maulin L., Maxwell M., Maynar J., Mazzoni T., Sweeney L. M., McArthur C., McCanny P., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McEvoy N., McGeer A., McKay C., McKeown J., McLean K. A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Mehkri O., Mele F., Melo L., Mendes J. J., Menon K., Mentre F., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miller J., Miranda-Maldonado H., Misnan N. A., Mohamed T. J., Eliza Mohamed N. N., Moin A., Molinos E., Molloy B., Monahan S., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Cely L. M., Moro L., Morton B., Motherway C., Motos A., Mouquet H., Perrot C. M., Moyet J., Mudara C., Muh N. Y., Muhamad D., Mullaert J., Muller F., Muller K. E., Murphy A., Murphy L., Murray P., Murris M., Murthy S., Musaab H., Muyandy G., Myrodia D. M., Nagpal D., Nagrebetsky A., Narasimhan M., Narayanan N., Nazerali-Maitland A., Neant N., Neb H., Neto R., Neumann E., Ng P. Y., Ng W. Y., Nghi A., Nguyen D., Choileain O. N., Leathlobhair N. N., Nichol A. D., Nitayavardhana P., Nonas S., Mohd Noordin N. A., Noret M., Izzati Norharizam N. F., Norman L., Noursadeghi M., Nowinski A., Nseir S., Nunez J. I., Nyamankolly E., Brien F. O., Callaghan A. O., O'Callaghan A., Occhipinti G., OConnor D., O'Donnell M., Ogston T., Ogura T., Oh T. -H., O'Halloran S., O'Hearn K., Ohshimo S., Oliveira J., Oliveira L., Olliaro P. L., Ong D. S. Y., Ong J. Y., Oosthuyzen W., Opavsky A., Openshaw P., Orozco-Chamorro C. M., Ortoleva J., Osatnik J., O'Shea L., O'Sullivan M., Othman S. Z., Ouamara N., Ouissa R., Oziol E., Pagadoy M., Pages J., Palacios A., Palmarini M., Panarello G., Panda P. K., Pang L. H., Panigada M., Pansu N., Papadopoulos A., Parke R., Pasquier J., Pastene B., Patauner F., Pathmanathan M. D., Patrao L., Patricio P., Patrier J., Patterson L., Paul C., Paul M., Paulos J., Paxton W. A., Payen J. -F., Peake S. L., Peariasamy K., Jimenez M. P., Peek G. J., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Pelosi P., Peltan I. D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrou L., Petrovic M., Petrov-Sanchez V., Pettersen F. O., Peytavin G., Pharand S., Picard W., Picone O., de Piero M., Pierobon C., Piersma D., Pimentel C., Pinto R., Piquard V., Pires C., Pironneau I., Piroth L., Piubelli C., Pius R., Plantier L., Png H. S., Poissy J., Pokeerbux R., Poli S., Pollakis G., Ponscarme D., Porto D. B., Post A. -M., Postma D. F., Povoa P., Povoas D., Powis J., Prapa S., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Pritchard M. G., Proenca L., Pudota S., Puechal O., Semedi B. P., Purcell G., Quesada L., Gonzalez V. Q., Quist-Paulsen E., Quraishi M., Qutishat F., Rabaud C., Rafael A., Rafiq M., Rahman R. A., Haji Ab Rahman A. K., Rainieri F., Rajahram G. S., Ramakrishnan N., Ramalho J., Ramli A. A., Rammaert B., Ramos G. V., Ranjan R., Rapp C., Rasmin M., Ratsep I., Ravi T., Real A., Rebaudet S., Redl S., Reeve B., Reid L., Reikvam D. H., Reis R., Rello J., Remppis J., Remy M., Ren H., Renk H., Resseguier A. -S., Revest M., Rewa O., Reyes T., Ribeiro M. I., Richardson D., Richier L., Atikah Ahmad Ridzuan S. N., Rios A. L., Rishu A., Rispal P., Risso K., Rizer N., Robba C., Roberto A., Roberts S., Robertson D. L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Roessler B., Roger P. -M., Roger C., Roilides E., Rojek A., Romaru J., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rossanese A., Rossetti M., Rossignol B., Rossignol P., Rousset S., Roy C., Roze B., Russell C. D., Ryan M., Ryckaert S., Holten A. R., Saba I., Sadat M., Sahraei V., Saint-Gilles M., Sakiyalak P., Salazar L., Sales G., Sallaberry S., Gandonniere C. S., Salvator H., Sanchez O., Sanchez E., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmento Banheiro B., Sarmiento I. C. E., Sarton B., Satyapriya S., Satyawati R., Saviciute E., Savvidou P., Saw Y. T., Schaffer J., Schermer T., Scherpereel A., Schneider M., Schroll S., Schwameis M., Scicluna B., Scott J. T., Scott-Brown J., Sedillot N., Seitz T., Selvarajoo M., Semaille C., Semple M. G., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Neto A. S., Balazote P. S., Shadowitz E., Shahidan S. A., Shamsah M., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheenan J. R., Shi H., Shime N., Shimizu K., Shrapnel S., Shum H. P., Mohammed N. S., Siang N. Y., Sibiude J., Siddiqui A., Sigfrid L., Sillaots P., Silva C., Silva R., Silva M. J., Lim Heng B. S., Sin W. C., Singh P., Singh B. C., Sitompul P. A., Sivam K., Skogen V., Smith S., Smood B., Smyth C., Smyth M., Snacken M., So D., Soh T. V., Solomon J., Solomon T., Somers E., Sommet A., Song R., Song M. J., Song T., Chia J. S., Sonntagbauer M., Soom A. M., Sotto A., Soum E., Sousa M., Sousa A. C., Uva M. S., Souza-Dantas V., Sperry A., Spinuzza E., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stolz E., Stone A., Streinu-Cercel A., Stuart A., Stuart D., Su R., Suen J. Y., Suen G., Sukumar P., Sultana A., Summers C., Supic D., Suppiah D., Surovcova M., Syahrin S., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Tagherset L., Taib S. M., Taleb S., Talsma J., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka H., Tanaka T., Taniguchi H., Tardivon C., Tattevin P., Taufik M. A., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tejada S., Tellier M. -C., Teoh S. 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M., Vajdovics C., Val-Flores L., Valran A., Van de Velde S., van den Berge M., Van der Feltz M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Someren Greve F., van Veen I., Van Willigen H., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vidal J. E., Vieira C., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Visseaux B., Visser H., Vitiello C., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Wainstein M., Walsh L., Wang C. -H., Webb S., Wei J., Weil K., Wen T. P., Wesselius S., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams B., Williams V., Williams P. J., Wils E. -J., Wittman J., Wong C., Wong X. C., Wong Y. S., Wong T. F., Xian G. E., Xian L. S., Kuan P. X., Xynogalas I., Binti Mohd Yakop S. R., Yamazaki M., Yarad E., Yazdanpanah Y., Liang Hing N. Y., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Binti Zaidan N. Z., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
Abstract: Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were mo
Published: 2023

144. Liver injury in hospitalized patients with COVID-19: An International observational cohort study

Author: Vijayaraghavan, B, Bishnu, S, Baruch, J, Citarella, B, Kartsonaki, C, Meeyai, A, Mohamed, Z, Ohshimo, S, Lefevre, B, Al-Fares, A, Calvache, J, Taccone, F, Olliaro, P, Merson, L, Adhikari, N, Abdukahil, S, Abdulkadir, N, Abe, R, Abel, L, Abrous, A, Absil, L, Acker, A, Adam, E, Adriao, D, Al Ageel, S, Ainscough, K, Hssain, A, Tamlihat, Y, Akimoto, T, Akmal, E, Al Qasim, E, Alberti, A, Al-Dabbous, T, Alegesan, S, Alessi, M, Alex, B, Alexandre, K, Alfoudri, H, Ali, I, Alidjnou, K, Aliudin, J, Allavena, C, Allou, N, Alves, J, Alves, R, Cabrita, J, Amaral, M, Amira, N, Ampaw, P, Andrejak, C, Angheben, A, Angoulvant, F, Ansart, S, Anthonidass, S, de Brito, C, Apriyana, A, Arabi, Y, Aragao, I, Arancibia, F, Araujo, C, Arcadipane, A, Archambault, P, Arenz, L, Arlet, J, Arnold-Day, C, Arora, L, Arora, R, Artaud-Macari, E, Aryal, D, Ashraf, M, Asif, N, Assie, J, Asyraf, A, Atif, M, Atique, A, Auchabie, J, Aumaitre, H, Auvet, A, Azemar, L, Azoulay, C, Bach, B, Bachelet, D, Badr, C, Baig, N, Baillie, J, Bak, E, Bakar, N, Bal, A, Balakrishnan, M, Balan, V, Bani-Sadr, F, Barbalho, R, Barbosa, N, Barclay, W, Barnett, S, Barnikel, M, Barrelet, A, Barrigoto, C, Bartoli, M, Basmaci, R, Basri, M, Bauer, J, Rincon, D, Beane, A, Bedossa, A, Bee, K, Begum, H, Behilill, S, Beishuizen, A, Beljantsev, A, Bellemare, D, Beltrame, A, Beltrao, B, Beluze, M, Benech, N, Benjiman, L, Benkerrou, D, Bennett, S, Bento, L, Berdal, J, Bergeaud, D, Bergin, H, Bertoli, G, Bessis, S, Bevilcaqua, S, Bezulier, K, Bhatt, A, Bhavsar, K, Bianco, C, Bidin, F, Singh, M, Humaid, F, Kamarudin, M, Bissuel, F, Biston, P, Bitker, L, Blier, C, Blot, M, Blumberg, L, Bodenes, L, Bogaert, D, Boivin, A, Bolanos, I, Bolze, P, Bompart, F, Borges, D, Borie, R, Botelho-Nevers, E, Bouadma, L, Bouchaud, O, Bouchez, S, Bouhmani, D, Bouhour, D, Bouiller, K, Bouillet, L, Bouisse, C, Boureau, A, Bourke, J, Bouscambert, M, Bousquet, A, Bouziotis, J, Boxma, B, Boyer-Besseyre, M, Boylan, M, Bozza, F, Braconnier, A, Braga, C, 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S., Iosifidis E., Ippolito M., Irawany V., Isgett S., Isidoro T., Ismail N., Isnard M., Ivulich D., Jaafar D., Jaafoura S., Jabot J., Jackson C., Jamieson N., Jaquet P., Jassat W., Jaud-Fischer C., Jaureguiberry S., Jego F., Jelani A. M., Jenum S., Jimbo-Sotomayor R., Joe O. Y., Jorge Garcia R. N., Joseph C., Joseph M., Jourdain M., Jung A., Juzar D., Kafif O., Kaguelidou F., Kaisbain N., Kaleesvran T., Kali S., Kamaluddin M. A. A., Kamaruddin Z. A. C., Kamarudin N., Kandel C., Kang K. Y., Karpayah P., Kasugai D., Kataria A., Katz K., Kay C., Kayyali L., Keane H., Keating S., Kelly A., Kelly C., Kelly N., Kelly S., Kelsey M., Kennon K., Kernan M., Kerroumi Y., Keshav S., Khalid I., Khalil A., Khan C., Khan I., Khanal S., Kho M. E., Khoo D., Khoo R., Khoo S., Kiat K. H., Kida Y., Kiiza P., Granerud B. K., Kim J. B., Kimmoun A., King A., Kitamura N., Klenerman P., Klont R., Bekken G. K., Knight S. R., Kobbe R., Kosgei C., Kpangon A., Krawczyk K., Krishnan S., Krishnan V., Kruglova O., Kumar D., Kumar G., Vecham P. K., Kurtzman E., Kutsogiannis D., Kutsyna G., Lachatre M., Lacoste M., Laffey J. G., Lafhej N., Lagrange M., Laine F., Lairez O., Lambert M., Langelot-Richard M., Langlois V., Lantang E. Y., Lanza M., Laouenan C., Laribi S., Lariviere D., Lasry S., Latif N., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence T., Le M., Bihan C. L., Bris C. L., Falher G. L., Fevre L. L., Hingrat Q. L., Marechal M. L., Mestre S. L., Moal G. L., Moing V. L., Nagard H. L., Turnier P. L., Lee B. H., Lee H. G., Lee J., Lee S. H., Lee T. C., Lee Y. L., Leeming G., Lefebvre B., Lefebvre L., LeGac S., Lelievre J. -D., Lellouche F., Lemaignen A., Lemee V., Lemeur A., Lemmink G., Lene H. S., Lennon J., Leone M., Lepiller Q., Lescure F. -X., Lesens O., Lesouhaitier M., Lester-Grant A., Letrou S., Levy B., Levy Y., Levy-Marchal C., Lewandowska K., L'Her E., Bassi G. L., Liegeon G., Lim K. C., Lim W. S., Lima C., Lina B., Lina L., Lind A., Lingas G., Lion-Daolio S., Lissauer S., Livrozet M., Lizotte P., Lolong N., Loon L. C., Lopes D., Loschner A. L., Loubet P., Loufti B., Louis G., Lourenco S., Low L. L., Lowik M., Loy J. S., Lucet J. C., Luna C. M., Luong L., Luque N., Luton D., Lwin N., Lyons R., Maasikas O., Mabiala O., Machado M., Machado S., Macheda G., Madiha H., Mahieu R., Mahy S., Maia A. R., Maier L. S., Maillet M., Maitre T., Malfertheiner M., Malik N., Mallon P., Malvy D., Manda V., Mandelbrot L., Manetta F., Mankikian J., Manning E., Manuel A., Malaque C. M. S., Marino F., Markowicz S., Eid C. M., Marsh L., Marshall J., Martelli C. T., Martin D. -A., Martin E., Martin-Blondel G., Martin-Loeches I., Martinot M., Martin-Quiros A., Martins A., Martins N., Rego C. M., Martucci G., Martynenko O., Marwali E. M., Marzukie M., Maslove D., Nor B. M., Matan M., Mathieu D., Mattei M., Matulevics R., Maulin L., Maxwell M., Mazzoni T., Sweeney L. M., McArthur C., McCarthy A., McCloskey C., McDermott S., McDonald S. E., McGeer A., McKeown J., McLean K. A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Mehkri O., Melo L., Mendes J. J., Mentre F., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miranda-Maldonado H., Misnan N. A., Mohamed N. N. E., Mohamed T. J., Moin A., Molinos E., Molloy B., Monahan S., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S., Moore S. C., Cely L. M., Moro L., Morton B., Motos A., Mouquet H., Perrot C. M., Moyet J., Mudara C., Muh N. Y., Muhamad D., Mullaert J., Muller F., Muller K. E., Munblit D., Murphy A., Murphy L., Murray P., Murris M., Murthy S., Musaab H., Muyandy G., Nagrebetsky A., Narasimhan M., Nazerali-Maitland A., Neant N., Neb H., Nekliudov N., Neto R., Neumann E., Nghi A., Nguyen D., Leathlobhair N. N., Nichol A., Nitayavardhana P., Nonas S., Noordin N. A. M., Noret M., Norharizam N. F. I., Norman L., Notari A., Noursadeghi M., Nowinski A., Nseir S., Nunez J. I., Nyamankolly E., Brien F. O., Callaghan A. O., O'Callaghan A., Occhipinti G., O'Connor D., O'Donnell M., Ogston T., Oliveira J., Oliveira L., Olliaro P. L., O'Neil C., Ong D. S. Y., Ong J. Y., Oosthuyzen W., Openshaw P., Orozco-Chamorro C. M., Ortoleva J., Osatnik J., O'Shea L., O'Sullivan M., Othman S. Z., Ouamara N., Ouissa R., Oziol E., Pagadoy M., Pages J., Mas A. P., Palmarini S., Panarello G., Panda P. K., Pang L. H., Panigada M., Pansu N., Papadopoulos A., Parke R., Pasquier J., Pastene B., Dass Pathmanathan M., Patrao L., Patricio P., Patrier J., Patterson L., Paul C., Paul M., Paulos J., Paxton W. A., Payen J. -F., Peariasamy K., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Peltan I. D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrovic M., Petrov-Sanchez V., Pettersen F. O., Peytavin G., Pharand S., Piagnerelli M., Picard W., Picone O., de Piero M., Pierobon C., Piersma D., Pimentel C., Piquard V., Pires C., Pironneau I., Piroth L., Pius R., Plantier L., Png H. S., Poissy J., Pokeerbux R., Poli S., Pollakis G., Ponscarme D., Porto D. B., Post A. -M., Postma D. F., Povoa P., Povoas D., Powis J., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Pritchard M. G., Proenca L., Puechal O., Semedi B. P., Purcell G., Quesada L., Quist-Paulsen E., Quraishi M., Qutishat F. -F., Rabaud C., Rafael A., Rafiq M., Rahman A. K. H. A., Rahman R. A., Rainieri F., Rajahram G. S., Ramakrishnan N., Ramalho J., Ramli A. A., Rammaert B., Ramos G. V., Rana A., Ranjan R., Rapp C., Rasmin M., Ratsep I., Rau C., Ravi T., Rebaudet S., Redl S., Reeve B., Reid L., Reikvam D. H., Reis R., Remppis J., Remy M., Ren H., Renk H., Resseguier A. -S., Revest M., Rewa O., Reyes L. F., Reyes T., Ribeiro M. I., Richardson D., Richier L., Ridzuan S. N. A. A., Rios A. L., Rishu A., Rispal P., Risso K., Nunez M. A. R., Rizer N., Roberto A., Roberts S., Robertson D. L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Roessler B., Roger P. -M., Roilides E., Rojek A., Romaru J., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rosenberger D., Rossanese A., Rossetti M., Rossignol B., Rossignol P., Rousset S., Roy C., Roze B., Russell C. D., Ryan M., Ryckaert S., Holten A. R., Saba I., Sadat M., Sahraei V., Saint-Gilles M., Sakiyalak P., Salazar L., Sales G., Sallaberry S., Gandonniere C. S., Salvator H., Sanchez O., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Banheiro B. S., Sarmiento I. C. E., Sarton B., Satyapriya S., Satyawati R., Saviciute E., Savvidou P., Saw Y. T., Schermer T., Scherpereel A., Schneider M., Schwameis M., Scott J. T., Scott-Brown J., Sedillot N., Selvarajoo M., Semaille C., Semple M. G., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Neto A. S., Shadowitz E., Shahidan S. A., Shamsah M., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheenan J. R., Shi H., Shimizu H., Shimizu K., Shrapnel S., Mohammed N. S., Siang N. Y., Sibiude J., Sigfrid L., Sillaots P., Silva M. J., Silva R., Heng B. S. L., Singh B. C., Sitompul P. A., Sivam K., Smith S., Smood B., Smyth M., Snacken M., Soh T. V., Solomon J., Solomon T., Somers E., Sommet A., Song M. J., Song T., Chia J. S., Sonntagbauer M., Soom A. M., Sotto A., Soum E., Sousa A. C., Sousa M., Uva M. S., Souza-Dantas V., Sperry A., Spinuzza E., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stone A., Streinu-Cercel A., Stuart A., Stuart D., Su R., Suen G., Suen J. Y., Sukumar P., Sultana A., Summers C., Suppiah D., Svistunov A., Syahrin S., Sztajnbok J., Szuldrzynski K., Tabrizi S., Tagherset L., Taib S. M., Taleb S., Talsma J., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka T., Tardivon C., Tattevin P., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tellier M. -C., Teoh S. K., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Thabit A. A. M., Tham Z. D., Thangavelu S., Theron E., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson S., Thomson D., Thomson E. C., Thurai S. R. T., Thwaites R. S., Tieroshyn V., Timashev P. S., Timsit J. -F., Tissot N., Toal F., Toh J. Z. Y., Tonby K., Tonnii S. L., Torre M., Torres A., Santos-Olmo R. M. T., Torres-Zevallos H., Trapani T., Trioux T., Tromeur C., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turmel J. -M., Turtle L. C. W., Tveita A., Uchiyama M., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Val-Flores L., Valran A., Van de Velde S., van den Berge M., Van der Feltz M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Veen I., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vickers J., Vidal J. E., Vieira C., Vijayan D., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Visseaux B., Vitiello C., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Wainstein M., Walsh L., Wang C. -H., Webb S., Wei J., Wen T. P., Wesselius S., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Willems S., Williams V., Wils E. -J., Wong C., Wong T. F., Wong X. C., Wong Y. S., Xian G. E., Xian L. S., Xuan K. P., Yakop S. R. B. M., Yamazaki M., Yazdanpanah Y., Hing N. Y. L., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Zaidan N. Z. B., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., and Zucman D.
Abstract: Background Using a large dataset, we evaluated prevalence and severity of alterations in liver enzymes in COVID-19 and association with patient-centred outcomes. Methods We included hospitalized patients with confirmed or suspected SARS-CoV-2 infection from the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) database. Key exposure was baseline liver enzymes (AST, ALT, bilirubin). Patients were assigned Liver Injury Classification score based on 3 components of enzymes at admission: Normal; Stage I) Liver injury: any component between 1-3x upper limit of normal (ULN); Stage II) Severe liver injury: any component ≥3x ULN. Outcomes were hospital mortality, utilization of selected resources, complications, and durations of hospital and ICU stay. Analyses used logistic regression with associations expressed as adjusted odds ratios (OR) with 95% confidence intervals (CI). Results Of 17,531 included patients, 46.2% (8099) and 8.2% (1430) of patients had stage 1 and 2 liver injury respectively. Compared to normal, stages 1 and 2 were associated with higher odds of mortality (OR 1.53 [1.37-1.71]; OR 2.50 [2.10-2.96]), ICU admission (OR 1.63 [1.48-1.79]; OR 1.90 [1.62-2.23]), and invasive mechanical ventilation (OR 1.43 [1.27-1.70]; OR 1.95 (1.55-2.45). Stages 1 and 2 were also associated with higher odds of developing sepsis (OR 1.38 [1.27-1.50]; OR 1.46 [1.25-1.70]), acute kidney injury (OR 1.13 [1.00-1.27]; OR 1.59 [1.32-1.91]), and acute respiratory distress syndrome (OR 1.38 [1.22-1.55]; OR 1.80 [1.49-2.17]). Conclusions Liver enzyme abnormalities are common among COVID-19 patients and associated with worse outcomes.
Published: 2023

145. One Left: A Novel

Author: Kim Soom, Bruce Fulton, Ju-Chan Fulton
Published: 2020

146. Performance Evaluation of Community Detection Algorithms Based on Relationship Strength Measurement.

Author: Soom Behera, Haoye Lu, and Amiya Nayak
Published: 2018
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147. Low-Investment, Realistic-Return Business Cases for Learning Analytics Dashboards: Leveraging Usage Data and Microinteractions.

Author: Tom Broos, Katrien Verbert, Greet Langie, Carolien Van Soom, and Tinne De Laet
Published: 2018
Full Text: View/download PDF

148. Multi-institutional positioning test feedback dashboard for aspiring students: lessons learnt from a case study in flanders.

Author: Tom Broos, Katrien Verbert, Greet Langie, Carolien Van Soom, and Tinne De Laet
Published: 2018
Full Text: View/download PDF

149. Low-Investment, Realistic-Return Business Cases for Learning Analytics Dashboards: Leveraging Usage Data and Microinteractions

Author: Broos, Tom, Verbert, Katrien, Langie, Greet, Van Soom, Carolien, De Laet, Tinne, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Pammer-Schindler, Viktoria, editor, Pérez-Sanagustín, Mar, editor, Drachsler, Hendrik, editor, Elferink, Raymond, editor, and Scheffel, Maren, editor
Published: 2018
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150. Comparison between Bridging Students and Traditional First-Year Students in Engineering Technology

Author: Van den Broeck, L., De Laet, T., Lacante, M., Pinxten, M., Van Soom, C., and Langie, G.
Abstract: To stimulate a flexible lifelong learning system students can enter university via lateral entry. Unlike traditional first-year students, lateral entrance students are not well-studied. Therefore this study focuses on comparing first-year students with a specific group of lateral entrants, namely bridging students at the Faculty of Engineering Technology, KU Leuven. Using Astin's Input-Environment-Outcome model resulted in (1) Input variables, namely prior education and initial learning and study strategies, (2) Environmental influence, measured with a questionnaire focussing on perceived transition to university, and (3) Outcome variables, namely dropout and academic achievement. Analyses resulted in similarities for the outcome variables, but differences in terms of secondary education. Regarding the input (LASSI) and environmental questionnaires, for only two of the 13 scales a moderate effect was found (perceived preparedness and test strategies). Consequently, research findings of first-year engineering students can be compared, taking into account their specific differences, to the context of bridging students.
Published: 2018
Full Text: View/download PDF

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