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101. Rapid chromatographic immunoassay-based evaluation of COVID-19: A cross-sectional, diagnostic test accuracy study & its implications for COVID-19 management in India

Author

Mathur, Purva, primary, Gupta, Ankesh, additional, Khurana, Surbhi, additional, Das, Rojaleen, additional, Srigyan, Deepankar, additional, Singh, Amit, additional, Mittal, Ankit, additional, Singh, Parul, additional, Soneja, Manish, additional, Kumar, Arvind, additional, Singh, AkhilKant, additional, Soni, KapilDev, additional, Meena, Suneeta, additional, Aggarwal, Richa, additional, Sharad, Neha, additional, Aggarwal, Anivita, additional, Kadnur, Harshith, additional, George, Netto, additional, Singh, Komal, additional, Desai, Devashish, additional, Trilangi, Praveen, additional, Khan, AdilRashid, additional, Kiro, VandanaV, additional, Naik, Shivdas, additional, Arunan, Bharthi, additional, Goel, Shivam, additional, Patidar, Diksha, additional, Lathwal, Amit, additional, Dar, Lalit, additional, Trikha, Anjan, additional, Pandey, RavindraMohan, additional, Malhotra, Rajesh, additional, Guleria, Randeep, additional, and Wig, Naveet, additional

Published
2021
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103. Gargle lavage & saliva: Feasible & cheaper alternatives to nasal & throat swabs for diagnosis of COVID-19

Author

Wig, Naveet, primary, Gupta, Ankesh, additional, Mittal, Ankit, additional, Dhakad, Shivram, additional, Brijwal, Megha, additional, Soneja, Manish, additional, Srigyan, Deepankar, additional, Xess, Ashit, additional, Kumar, Arvind, additional, Ray, Animesh, additional, Meena, VedPrakash, additional, Garg, RohitKumar, additional, Singh, Komal, additional, Desai, Devashish, additional, Chowdhury, Mohit, additional, Chowdhury, Souradeep, additional, Sharma, Kunal, additional, Narayan, Ananthu, additional, Krishnan, GRahul, additional, Naik, Shivdas, additional, Dar, Lalit, additional, Pandey, RavindraMohan, additional, Pandey, Shivam, additional, and Sinha, Sanjeev, additional

Published
2021
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105. Leucocytosis and early organ involvement as risk factors of mortality in adults with dengue fever

Author

Baitha, Upendra, primary, Halkur Shankar, Sujay, additional, Kodan, Parul, additional, Singla, Paras, additional, Ahuja, Jatin, additional, Agarwal, Samagra, additional, Gupta, Anant, additional, Jorwal, Pankaj, additional, Soneja, Manish, additional, Ranjan, Piyush, additional, Kumar, Arvind, additional, Baruah, Kalpana, additional, and Biswas, Ashutosh, additional

Published
2020
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108. Low Dose Radiation Therapy for COVID-19 Pneumonia: A Pilot Study

Author

Sharma, Daya Nand, primary, Guleria, Randeep, additional, Wig, Naveet, additional, Mohan, Anant, additional, Rath, Goura Kisor, additional, Subramani, Vellaiyan, additional, Bhatnagar, Sushma, additional, Mallick, Supriya, additional, Sharma, Aman, additional, Patil, Pritee, additional, Madan, Karan, additional, Soneja, Manish, additional, Thulkar, Sanjay, additional, Singh, Angel Rajan, additional, and Singh, Sheetal, additional

Published
2020
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110. Hydroxychloroquine pre-exposure prophylaxis for COVID-19 among healthcare workers: Initial experience from India.

Author

Kadnur, Harshith, Aggarwal, Anivita, Soneja, Manish, Singh, Komal, Mittal, Ankit, Nischal, Neeraj, Tirlangi, Praveen, Khan, Adil, Desai, Devashish, Gupta, Ankesh, Kumar, Arvind, Jorwal, Pankaj, Biswas, Ashutosh, Pandey, Ravindra, Wig, Naveet, and Guleria, Randeep

Subjects
CORONAVIRUS diseases, SARS-CoV-2, MEDICAL personnel, PRE-exposure prophylaxis, COVID-19, HYDROXYCHLOROQUINE
Abstract

Background: Hydroxychloroquine (HCQ) had generated considerable interest for coronavirus disease 2019 (COVID-19) prophylaxis. We conducted a prospective observational study at a tertiary care hospital in India, with dedicated COVID-19 care facilities. Objectives: Primary objective was incidence of adverse effects, secondary objective being efficacy in preventing COVID-19. Methods: Healthcare workers were recruited and grouped based on voluntary HCQ prophylaxis as per national guidelines. Side effects in HCQ group were graded in accordance with national cancer institute-common terminology criteria for adverse events (NCI-CTCAE) version 5.0. At 3–7-week follow-up, groups were compared for COVID-19 exposure, symptoms development and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR results. Results: Among 358 participants recruited, 216 (60.3%) were males and mean age was 31.2 ± 6.6 years. Chemoprophylaxis was initiated by 258 (72%) participants. After loading dose, 7 (2.7%) reported grade 2 and 1 (0.4%) grade 3 adverse effects. Discontinuation of HCQ due to side effects was reported in 11 (4.3%) participants. Electrocardiogram was done by 50 (19.4%) participants on HCQ; no abnormalities were noted. A total of 106 (41%) among those taking and 63 (63%) among those not taking HCQ were tested for SARS-CoV-2 due to influenza-like illness or significant exposure. Among all participants, 25 (6.9%, 95% confidence interval [CI] 4.3–9.6) developed COVID-19 during the study period. In the group taking HCQ, 10 (3.9%) tested positive compared to 15 (15%) in the group not taking HCQ (P < 0.001). Odds ratio with HCQ intake was 0.34 (95% CI 0.13–0.83, P = 0.01) and the number needed to treat was 12. Conclusion: HCQ is safe at the recommended dose for pre-exposure prophylaxis of COVID-19. [ABSTRACT FROM AUTHOR]

Published
2022
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111. Diagnostic utility of chest computerized tomography in the diagnosis of recurrence among sputum scarce and sputum negative previously treated pulmonary tuberculosis suspects.

Author

Bharath, B, Ray, Animesh, Jorwal, Pankaj, Vyas, Surabhi, Soneja, Manish, Biswas, Ashutosh, Sinha, Sanjeev, and Khan, Maroof

Subjects
TUBERCULOSIS, SPUTUM, COMPUTED tomography, TOMOGRAPHY, PULMONARY aspergillosis, HIV-positive persons
Abstract

Objective: The objective was to study the sensitivity, specificity, and diagnostic accuracy of various computed tomography (CT) chest findings in diagnosing recurrence among pulmonary tuberculosis (PTB) suspects. Materials and Methods: A prospective observational study was conducted in a tertiary care hospital in New Delhi. A total of 130 suspects with a past history of treatment for PTB, who presented with any of the symptoms suggestive of recurrence were included. Sputum-positive, HIV-positive patients, pregnant females, and patients aged <18 years were excluded. Patients underwent CT chest followed by bronchoalveolar lavage (BAL). Results: A total of 62 patients were there in the final analysis. The median age of the patients with recurrent PTB was 27.5 years. Cough was the universal symptom in all these patients (>90%). Hemoptysis was the predominant symptom among patients with chronic pulmonary aspergillosis (66.6%). Necrotic mediastinal lymph nodes had good diagnostic accuracy of 88.71% with area under the curve of 0.806, P < 0.001 in diagnosing recurrent TB. BAL GeneXpert and mycobacteria growth indicator tube had good sensitivity (83.33% and 84.62%, respectively), specificity (100% for both), and excellent diagnostic accuracy (95.16% and 96.36%, respectively) for diagnosing recurrence in sputum negative and sputum scarce patient, (P < 0.001) when compared with composite reference standard. For culture-positive cases, BAL GeneXpert MTB/RIF had 100% sensitivity and 97.73% specificity in diagnosing recurrent PTB patients. Conclusion: The presence of mediastinal necrotic lymph node is the most accurate CT finding that can differentiate recurrent TB from post-TB sequelae. No other single chest CT scan finding had reliable diagnostic accuracy in comparison to microbiological tools in diagnosing recurrence among sputum negative or scarce previously treated PTB suspects. [ABSTRACT FROM AUTHOR]

Published
2022
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112. SARS-CoV-2 RT-PCR profile in 298 Indian COVID-19 patients: a retrospective observational study

Author

Bhattacharya, Bisakh, primary, Kumar, Rohit, additional, Meena, Ved Prakash, additional, Soneja, Manish, additional, Singh, Amit, additional, Das, Rojaleen, additional, Xess, Ashit, additional, Arif, Nazneen, additional, Vig, Saurabh, additional, Rastogi, Vandana, additional, Tiwari, Pavan, additional, Bhatnagar, Sushma, additional, Mohan, Anant, additional, Wig, Naveet, additional, and Dar, Lalit, additional

Published
2020
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117. Seroprevalence of anti-SARS-CoV-2 IgG antibodies in hospitalized patients at a tertiary referral center in North India

Author

Ray, Animesh, primary, Singh, Komal, additional, Chattopadhyay, Souvick, additional, Mehdi, Farha, additional, Batra, Gaurav, additional, Gupta, Aakansha, additional, Agarwal, Ayush, additional, Bhavesh, M, additional, Sahni, Shubham, additional, Chaithra, R, additional, Agarwal, Shubham, additional, Nagpal, Chitrakshi, additional, Gagantej, B H, additional, Arora, Umang, additional, Sharma, Kartikeya Kumar, additional, Jadon, Ranveer Singh, additional, Upadhyay, Ashish Datt, additional, Nischal, Neeraj, additional, Vikram, Naval K, additional, Soneja, Manish, additional, Pandey, R M, additional, and Wig, Naveet, additional

Published
2020
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118. Role of Voriconazole in the Management of Invasive Central Nervous System Aspergillosis: A Case Series from a Tertiary Care Centre in India

Author

Gupta, Nitin, primary, Kodan, Parul, additional, Mittal, Ankit, additional, Singh, Gagandeep, additional, Netto, George, additional, Ramteke, Prashant, additional, Malla, Sundeep, additional, Kumar, Rohit, additional, Kumar, Tirlangi Praveen, additional, Singh, Komal, additional, Aggarwal, Anivita, additional, Desai, Devashish, additional, Soneja, Manish, additional, Xess, Immaculata, additional, and Wig, Naveet, additional

Published
2020
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120. Management of mild COVID-19: Policy implications of initial experience in India

Author

Kumar, Rohit, primary, Bhattacharya, Bisakh, additional, Meena, Ved Prakash, additional, Aggarwal, Anivita, additional, Tripathi, Manasi, additional, Soneja, Manish, additional, Mittal, Ankit, additional, Singh, Komal, additional, Gupta, Nishkarsh, additional, Garg, Rakesh Kumar, additional, Ratre, Brajesh Kumar, additional, Kumar, Balbir, additional, Bhopale, Shweta Arun, additional, Tiwari, Pavan, additional, Verma, Ankit, additional, Bhatnagar, Sushma, additional, Mohan, Anant, additional, Wig, Naveet, additional, and Guleria, Randeep, additional

Published
2020
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123. Brain abscess in patients with chronic kidney disease: A case-based approach to management in resource-limited settings

Author

Gupta, Nitin, primary, Kumar, Rohit, additional, Banerjee, Sayantan, additional, Singh, Gagandeep, additional, Malla, Sundeep, additional, Ray, Yogiraj, additional, Ramteke, Prashant, additional, George, Netto, additional, Kodan, Parul, additional, Aggarwal, Anivita, additional, Kumar, Prabhat, additional, Jorwal, Pankaj, additional, Soneja, Manish, additional, and Biswas, Ashutosh, additional

Published
2020
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124. Zika outbreak in India in 2018

Author

Biswas, Ashutosh, primary, Kodan, Parul, primary, Gupta, Nitin, primary, Soneja, Manish, primary, Baruah, Kalpana, primary, Sharma, K K, primary, and Meena, Sheela, primary

Published
2020
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125. Mutation in atpE and Rv0678 genes associated with bedaquline resistance among drug-resistant tuberculosis patients: A pilot study from a high-burden setting in Northern India

Author

Soneja, Manish, primary, Singh, BinitKumar, additional, Sharma, Rohini, additional, Chaubey, Jigyasa, additional, Kodan, Parul, additional, Jorwal, Pankaj, additional, Nischal, Neeraj, additional, Chandra, Shivani, additional, Ramachandran, Ranjani, additional, and Wig, Naveet, additional

Published
2020
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126. Clinico-demographic profile & hospital outcomes of COVID-19 patients admitted at a tertiary care centre in north India

Author

Mohan, Anant, primary, Tiwari, Pawan, additional, Bhatnagar, Sushma, additional, Patel, Ankit, additional, Maurya, Abhishek, additional, Dar, Lalit, additional, Pahuja, Sourabh, additional, Garg, Rakesh, additional, Gupta, Nishkarsh, additional, Sahoo, Biswajeet, additional, Gupta, Ritu, additional, Meena, VedPrakash, additional, Vig, Saurabh, additional, Pandit, Anuja, additional, Mittal, Saurabh, additional, Madan, Karan, additional, Hadda, Vijay, additional, Dwivedi, Tanima, additional, Choudhary, Aashish, additional, Brijwal, Megha, additional, Soneja, Manish, additional, Guleria, Randeep, additional, Ratre, Brajesh, additional, Kumar, Balbir, additional, Bhopale, Shweta, additional, Panda, Smriti, additional, Singh, AngelRajan, additional, Singh, Sheetal, additional, and Wundavalli, Laxmitej, additional

Published
2020
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128. Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 Among Healthcare Workers: Initial Experience from India

Author

Kadnur, Harshith B., primary, Aggarwal, Anivita, additional, Soneja, Manish, additional, Singh, Komal, additional, George, Netto, additional, Nischal, Neeraj, additional, Trilangi, Praveen, additional, Khan, Adil Rashid, additional, Desai, Devashish, additional, Mittal, Ankit, additional, Arunan, Bharathi, additional, Patidar, Diksha, additional, Gupta, Ankesh, additional, Kumar, Arvind, additional, Soni, Kapil Dev, additional, Jorwal, Pankaj, additional, Agarwal, Richa, additional, Baidya, Dalim K., additional, Mathur, Purva, additional, Bhatnagar, Sushma, additional, Trikha, Anjan, additional, Rajeshwari, S., additional, Biswas, Ashutosh, additional, Pandey, Ravindra, additional, Wig, Naveet, additional, and Guleria, Randeep, additional

Published
2020
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129. Nontuberculous mycobacteria: A report of eighteen cases from a tertiary care center in India

Author

Soneja, Manish, primary, Gupta, Nitin, additional, Mittal, Ankit, additional, Muhammed Niyas, VettakkaraKandy, additional, Banerjee, Sayantan, additional, Ray, Yogiraj, additional, Kodan, Parul, additional, Malla, Sundeep, additional, Khot, Wasim, additional, Fazal, Farhan, additional, Singh, BinitKumar, additional, Jorwal, Pankaj, additional, Nischal, Neeraj, additional, and Wig, Naveet, additional

Published
2020
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137. Characteristics and outcomes of 231 COVID-19 cases admitted at a tertiary facility in India: An observational cohort study

Author

Soneja, Manish, primary, Kumar, Rohit, additional, Bhattacharya, Bisakh, additional, Meena, VedPrakash, additional, Aggarwal, Anivita, additional, Tripathi, Manasi, additional, Mittal, Ankit, additional, Singh, Komal, additional, Gupta, Nishkarsh, additional, Garg, RakeshKumar, additional, Ratre, BrajeshKumar, additional, Kumar, Balbir, additional, Bhopale, ShwetaArun, additional, Tiwari, Pavan, additional, Verma, Ankit, additional, Bhatnagar, Sushma, additional, Mohan, Anant, additional, Wig, Naveet, additional, and Guleria, Randeep, additional

Published
2020
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138. Gargle lavage as a viable alternative to swab for detection of SARS-CoV-2

Author

Wig, Naveet, primary, Mittal, Ankit, additional, Gupta, Ankesh, additional, Kumar, Shiv, additional, Surjit, Milan, additional, Singh, Binit, additional, Soneja, Manish, additional, Soni, KapilDev, additional, Khan, AdilRashid, additional, Singh, Komal, additional, Naik, Shivdas, additional, Kumar, Arvind, additional, Aggarwal, Richa, additional, Nischal, Neeraj, additional, Sinha, Sanjeev, additional, and Trikha, Anjan, additional

Published
2020
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143. Atypical bacterial co-infections among patients with COVID-19: A study from India.

Author

Chaudhry, Rama, Sreenath, K., Batra, Priyam, Vinayaraj, E. V., Rathor, Nisha, Saikiran, K. V. P., Aravindan, Ajisha, Singh, Vishwajeet, Brijwal, Megha, Soneja, Manish, Verma, Nishant, Subramanium, Rajeshwari, Singh, Urvashi B., and Guleria, Randeep

Subjects
COVID-19, SARS-CoV-2, MYCOPLASMA pneumoniae infections, LENGTH of stay in hospitals, LEGIONELLA pneumophila, MYCOPLASMA pneumoniae
Abstract

Emerging evidence shows co-infection with atypical bacteria in coronavirus disease 2019 (COVID-19) patients. Respiratory illness caused by atypical bacteria such as Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila may show overlapping manifestations and imaging features with COVID-19 causing clinical and laboratory diagnostic issues. We conducted a prospective study to identify co-infections with SARS-CoV-2 and atypical bacteria in an Indian tertiary hospital. From June 2020 to January 2021, a total of 194 patients with laboratoryconfirmed COVID-19 were also tested for atypical bacterial pathogens. For diagnosing M. pneumoniae, a real-time polymerase chain reaction (PCR) assay and serology (IgM ELISA) were performed. C. pneumoniae diagnosis was made based on IgM serology. L. pneumophila diagnosis was based on PCR or urinary antigen testing. Clinical and epidemiological features of SARS-CoV-2 and atypical bacteria-positive and -negative patient groups were compared. Of the 194 patients admitted with COVID-19, 17 (8.8%) were also diagnosed with M. pneumoniae (n = 10) or C. pneumoniae infection (n = 7). Confusion, headache, and bilateral infiltrate were found more frequently in the SARS CoV-2 and atypical bacteria co-infection group. Patients in the M. pneumoniae or C. pneumoniae co-infection group were more likely to develop ARDS, required ventilatory support, had a longer hospital length of stay, and higher fatality rate compared to patients with only SARS-CoV-2. Our report highlights co-infection with bacteria causing atypical pneumonia should be considered in patients with SARS-CoV-2 depending on the clinical context. Timely identification of co-existing pathogens can provide pathogen-targeted treatment and prevent fatal outcomes of patients infected with SARS-CoV-2 during the current pandemic. [ABSTRACT FROM AUTHOR]

Published
2022
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144. Comparison of High-Flow Nasal Cannula and Noninvasive Ventilation in Acute Hypoxemic Respiratory Failure Due to Severe COVID-19 Pneumonia.

Author

Ramachandran Nair, Parvathy, Haritha, Damarla, Behera, Srikant, Athiphro Kayina, Choro, Maitra, Souvik, Kumar Anand, Rahul, Ranjan Ray, Bikash, Soneja, Manish, Subramaniam, Rajeshwari, and Kumar Baidya, Dalim

Subjects
INTENSIVE care units, NASAL cannula, RESPIRATORY insufficiency, COVID-19, ACADEMIC medical centers, CONFIDENCE intervals, INTUBATION, TIME, CONTINUING education units, DISEASE incidence, TERTIARY care, MANN Whitney U Test, ARTIFICIAL respiration, RANDOMIZED controlled trials, HOSPITAL mortality, T-test (Statistics), DESCRIPTIVE statistics, CHI-squared test, KAPLAN-Meier estimator, SURVIVAL analysis (Biometry), STATISTICAL sampling, REACTIVE oxygen species, ODDS ratio, DATA analysis software, OXYGEN in the body, LONGITUDINAL method
Abstract

BACKGROUND: Efficacy of high-flow nasal cannula (HFNC) over noninvasive ventilation (NIV) in severe coronavirus disease 2019 (COVID-19) pneumonia is not known. We aimed to assess the incidence of invasive mechanical ventilation in patients with acute hypoxemic respiratory failure due to COVID-19 treated with either HFNC or NIV. METHODS: This was a single-center randomized controlled trial performed in the COVID-19 ICU of a tertiary care teaching hospital in New Delhi, India. One hundred and nine subjects with severe COVID-19 pneumonia presenting with acute hypoxemic respiratory failure were recruited and allocated to either HFNC (n = 55) or NIV (n = 54) arm. Primary outcome was intubation by 48 h. Secondary outcomes were improvement in oxygenation by 48 h, intubation rate at day 7, and in-hospital mortality. RESULTS: Baseline characteristics and PaO2/FIO2 ratio were similar in both the groups. Intubation rate at 48 h was similar between the groups (33% NIV vs 20% HFNC, relative risk 0.6, 95% CI 0.31-1.15, P = .12). Intubation rate at day 7 was lower in the HFNC (27.27%) compared to the NIV group (46.29%) (relative risk 0.59, 95% CI 0.35-0.99, P = .045), and this difference remained significant after adjustment for the incidence of chronic kidney disease and the arterial pH (adjusted OR 0.40, 95% CI 0.17-0.93, P = .03). Hospital mortality was similar between HFNC (29.1%) and NIV (46.2%) group (relative risk 0.6, 95% CI 0.38-1.04, P = .06). CONCLUSIONS: We were not able to demonstrate a statistically significant improvement of oxygenation parameters nor of the intubation rate at 48 h between NIV and HFNC. These findings should be further tested in a larger randomized controlled trial. [ABSTRACT FROM AUTHOR]

Published
2021
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145. Central airway abnormalities – More than meets the eye.

Author

Singh, Swish Kumar, Jana, Manisha, Bhalla, Ashu Seith, Naranje, Priyanka, Ray, Animesh, Soneja, Manish, and Khan, Adil Rashid

Subjects
AIRWAY (Anatomy), RESPIRATORY organs, HUMAN abnormalities, DIFFERENTIAL diagnosis
Abstract

Central airway abnormalities are the most overlooked part of the respiratory system during high‑resolution computed tomography thorax specifically when these are subtle and read by less experienced eyes. In this article, we have tried to emphasize the importance to include central airways in reporting checklist. Systematically, analysis of airways can give important clues and narrow down the differentials and clinch the diagnosis in some cases like in our index one. [ABSTRACT FROM AUTHOR]

Published
2021
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