101. Chronic obstructive lung disease 'expert system': Validation of a predictive tool for assisting diagnosis
- Author
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Braido, Fulvio, Santus, Pierachille, Corsico, Angelo Guido, Di Marco, Fabiano, Melioli, Giovanni, Scichilone, Nicola, Solidoro, Paolo, Braido, Fulvio, Santus, Pierachille, Corsico, Angelo Guido, Di Marco, Fabiano, Melioli, Giovanni, Scichilone, Nicola, and Solidoro, Paolo
- Subjects
Pulmonary and Respiratory Medicine ,Chronic Obstructive ,Pilot Projects ,Expert Systems ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,Pulmonary Disease ,Pulmonary Disease, Chronic Obstructive ,Software Design ,Surveys and Questionnaires ,Chronic obstructive lung disease ,Diagnosis ,Surveys and Questionnaire ,Humans ,Age Factor ,Pilot Project ,Expert System ,Chronic obstructive lung diseases ,Aged ,Health Policy ,Environmental and Occupational Health ,Public Health, Environmental and Occupational Health ,Methodology ,Age Factors ,Chronic obstructive lung diseases, Diagnosis, Expert systems, Pulmonary and Respiratory Medicine, Health Policy, Public Health, Environmental and Occupational Health ,Middle Aged ,Asthma ,Cough ,Spirometry ,Sample Size ,Chronic Disease ,Public Health ,Expert systems ,Diagnosi ,Human - Abstract
Purpose: The purposes of this study were development and validation of an expert system (ES) aimed at supporting the diagnosis of chronic obstructive lung disease (COLD). Methods: A questionnaire and a WebFlex code were developed and validated in silico. An expert panel pilot validation on 60 cases and a clinical validation on 241 cases were performed. Results: The developed questionnaire and code validated in silico resulted in a suitable tool to support the medical diagnosis. The clinical validation of the ES was performed in an academic setting that included six different reference centers for respiratory diseases. The results of the ES expressed as a score associated with the risk of suffering from COLD were matched and compared with the final clinical diagnoses. A set of 60 patients were evaluated by a pilot expert panel validation with the aim of calculating the sample size for the clinical validation study. The concordance analysis between these preliminary ES scores and diagnoses performed by the experts indicated that the accuracy was 94.7% when both experts and the system confirmed the COLD diagnosis and 86.3% when COLD was excluded. Based on these results, the sample size of the validation set was established in 240 patients. The clinical validation, performed on 241 patients, resulted in ES accuracy of 97.5%, with confirmed COLD diagnosis in 53.6% of the cases and excluded COLD diagnosis in 32% of the cases. In 11.2% of cases, a diagnosis of COLD was made by the experts, although the imaging results showed a potential concomitant disorder. Conclusion: The ES presented here (COLDES) is a safe and robust supporting tool for COLD diagnosis in primary care settings.
- Published
- 2018