Author: "Soledad Romero" - Searchworks@Jio Institute Digital Library Search Results

295 results on '"Soledad Romero"'

101. S20. LIFETIME PSYCHOPATHOLOGY IN CHILD AND ADOLESCENT OFFSPRING OF PARENTS DIAGNOSED WITH SCHIZOPHRENIA OR BIPOLAR DISORDER

Author: Elena de la Serna, Dolores Moreno, Gisela Sugranyes, Josefina Castro-Fornieles, Ana Espliego, Elisa Rodríguez, Inmaculada Baeza, Daniel Ilzarbe, Miriam Ayora, and Soledad Romero
Subjects: medicine.medical_specialty, Poster Session I, AcademicSubjects/MED00810, business.industry, Offspring, medicine.disease, Child and adolescent, Psychiatry and Mental health, Schizophrenia, medicine, Bipolar disorder, Psychiatry, business, Psychopathology
Abstract: Background Having one parent diagnosed with a severe mental disorder is considered one of the main risk factors for developing that disorder in adulthood and it also increases the risk of a wide range of mental disorders in the offspring from early childhood and adolescence. The aim of this study is to analyze the prevalence of several psychopathological diagnoses, the presence of prodromal symptoms and global functioning in schizophrenia offspring (SZoff) or bipolar offspring (BDoff) compared to community control offspring (CCoff) at baseline and 2-year follow-up. Methods 41 SZoff, 97 BDoff and 107 CCoff between 7 and 17 years were included. Clinical assessment consisted of a clinical evaluation using the following instruments: structured interview KSADS-PL or SCID-I, semi-structured Interview for Prodromal Syndromes (SIPS) and the Children’s Global Assessment Scale (CGAS). To test between-group differences in DSM-IV diagnoses multilevel mixed-effect logistic regression models (categorical variables) or linear (continuous variables) regression models were conducted with group (SZoff, BDoff and CCoff), time (baseline or 2-year follow-up), interaction time x group, age, gender and socio-economic status as fixed variables. Results Significant differences between groups were found in any lifetime axis I disorder (F=8.720; p Discussion Screening patients’ children is clinically relevant since, as a group, they have an elevated risk of developing a psychiatric disorder and of experiencing their first symptoms during childhood and adolescence.
Published: 2020

102. Intrinsic functional connectivity of fronto-temporal networks in adolescents with early psychosis

Author: Olga Puig, Núria Bargalló, Josefina Castro-Fornieles, Inmaculada Baeza, Cristina Solé-Padullés, Gisela Sugranyes, Vanessa Sánchez-Gistau, Elena de la Serna, Soledad Romero, and Anna Calvo
Subjects: Male, medicine.medical_specialty, Psychosis, Adolescent, Inferior frontal gyrus, Audiology, Developmental psychology, 03 medical and health sciences, 0302 clinical medicine, Neuroimaging, Fractional anisotropy, Developmental and Educational Psychology, medicine, Humans, Child, Association (psychology), medicine.diagnostic_test, Early psychosis, General Medicine, medicine.disease, Magnetic Resonance Imaging, Frontal Lobe, 030227 psychiatry, Psychiatry and Mental health, Psychotic Disorders, Pediatrics, Perinatology and Child Health, Female, Psychology, Functional magnetic resonance imaging, 030217 neurology & neurosurgery, Diffusion MRI
Abstract: Adults with psychotic disorders have abnormal connectivity of fronto-temporal networks. However, whether these abnormalities are present in adolescents with early psychosis has not been fully assessed. One-hundred and thirty-nine adolescents aged 12-18 underwent resting-state functional magnetic resonance imaging and diffusion tensor imaging. Following motion correction, data were available for 44 participants with a psychosis risk syndrome, 34 patients with a first episode psychosis (FEP) and 35 healthy controls. Independent component analysis was performed to assess functional networks showing a fronto-temporal scope; this identified a language and a salience network. Mean fractional anisotropy was measured in clusters showing between-group differences in intrinsic functional connectivity (iFC). For the language network, there was a group effect within the right middle/inferior frontal gyrus, explained by reduced iFC in patients with an FEP relative to healthy controls, while in participants with a psychosis risk syndrome values of iFC were intermediate. In this region, values of iFC were positively correlated with mean fractional anisotropy in patients with an FEP. No group differences were observed in the salience network. Reduced iFC of the language network, in association with disrupted white matter microstructure, may characterize FEP during adolescence.
Published: 2016

103. Aproximaciones: hacia una política de la alteridad en la obra de Juan L. Ortiz

Author: Laura Soledad Romero
Subjects: Alterity, Philosophy, Dialectica interpretation, Humanities
Abstract: espanolDe modo muy esquematico, las lecturas criticas de la obra poetica de Juan Laurentino Ortiz se dividen en dos grupos: uno, cuyo nucleo es la representacion de la naturaleza, atiende a la relacion fusional o mistica entre el sujeto y el paisaje; el otro, cuyo nucleo es la realidad social, considera las dimensiones historicas y politicas. Nuestra hipotesis es que la obra de Ortiz reclama una reconsideracion de las categorias politicas que subyacen a sus diferentes lecturas, a partir de una indagacion del problema de la otredad como alteridad radical. En este sentido, el problema de la animalidad permite considerar una dimension que escapa a la alternativa critica. Los animales (asi como otros entes no humanos) solicitan una consideracion etica, pues plantean la relacion entre el sujeto y el paisaje como tension irresoluble que no puede desembocar en ninguna sintesis armonica. Reconsiderar el problema politico a la luz de la etica implica conmover la dicotomia naturaleza/cultura y, en consecuencia, volver a plantear los terminos para otra lectura politica de esta obra que se sustraeria a la dialectica. EnglishIn a very schematic way, the critical readings of the poetic work of Juan Laurentino Ortiz are divided into two groups: one, whose nucleus is the representation of nature, attends to the fusion or mystical relationship between the subject and the landscape; the other one, whose nucleus is social reality, considers the historical and political dimensions. Our hypothesis is that the Ortiz’s work claim for a reconsideration of the political categories that underlie his different readings, based on an inquiry into the problem of otherness as a radical alterity. In this way, the problem of animality allows us to consider a dimension that escapes the critical alternative. Animals (as well as other non-human entities) request an ethical consideration, because they place the problem of the relation between the subject and the landscape as an unsolvable tension that can not lead to any harmonic synthesis. Reconsidering the political problem in the light of ethics implies shake the nature/culture dichotomy and, consequently, rethinking the terms for another political reading of this work that was removed from the dialectic.
Published: 2019

104. Fronto-Limbic Connectivity as a Predictor of Improvement in Nonsuicidal Self-Injury in Adolescents Following Psychotherapy

Author: Marisol Picado, Miguel Romero, Pilar Santamarina-Perez, Elena Moreno, Manpreet K. Singh, Iria Mendez, Gisela Sugranyes, Astrid Morer, Mary Melissa Packer, Elena Font, Soledad Romero, Esteve Martínez, and Sara M. Leslie
Subjects: Male, Adolescent, Psychological intervention, Vulnerability, Poison control, Amygdala, Suicide prevention, 03 medical and health sciences, 0302 clinical medicine, Injury prevention, medicine, Limbic System, Humans, Pharmacology (medical), Child, Resting state fMRI, Human factors and ergonomics, Brain, Magnetic Resonance Imaging, 030227 psychiatry, Frontal Lobe, COVID-19 Drug Treatment, Psychotherapy, Psychiatry and Mental health, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Female, Psychology, Coronavirus Infections, Self-Injurious Behavior, 030217 neurology & neurosurgery, Clinical psychology
Abstract: Objectives: Key neurobiological factors contribute to vulnerability to nonsuicidal self-injury (NSSI) among adolescents and how they respond to treatment targeted to reduce such behaviors....
Published: 2019

105. Functional Impairment and Clinical Correlates in Adolescents with Bipolar Disorder Compared to Healthy Controls. A Case-control Study

Author: Iria, Mendez, Josefina, Castro-Fornieles, Sara, Lera-Miguel, Marisol, Picado, Roger, Borras, Sandra, Cosi, Marc, Valenti, Pilar, Santamarina, Elena, Font, and Soledad, Romero
Subjects: Research Article
Abstract: Evidence shows that most adolescents with bipolar disorder (BD) achieve syndromic recovery after being referred to specialized treatment. However, functional recovery is reached in less than 50% of those cases.Descriptive cross-sectional case-control study, based on a clinical sample of 44 BD patients aged 12-19, matched by age and sex with 44 healthy controls (HC). Psychopathology was ascertained using the KSADS-PL, in addition to the clinical scales. Information about previous academic performance was included, as well as functional outcome based on the Children's Global Assessment Functioning Scale (CGAS). Previous exposure to stressful experiences was assessed using the Schedule for Stressful Life Events (SLES). All analyses were performed using either conditional or stepwise logistic regression models.Once they have become stabilized, and even after controlling for socio-demographic differences, BD patients were associated with lower levels of functionality [OR 0.65 (0.46, 0.93), p=0.02], and worse performance at school [OR 0.03 (0.01, 0.67), p=0.03] compared with HC. Persistent sub-syndromal psychosis showed the strongest negative correlation with functionality (rho=-0.65, -0.57 for BD and HC respectively; p0.001). Although BD was associated with more stressful life events, this association did not remain significant in the multivariate models.The small sample size limits our ability to detect differences between groups, and between BD subtypes.Even when early detection and intervention is provided, BD has a significant impact on functioning and academic performance. It is important to address persistent sub-threshold symptoms and to emphasize the social and rehabilitative components of treatment.Les données probantes indiquent que la plupart des adolescents souffrant de trouble bipolaire (TB) obtiennent un rétablissement syndromique après avoir été adressés à un traitement spécialisé. Cependant, le rétablissement fonctionnel n’est réalisé que dans moins de 50 % de ces cas.Une étude cas-témoins transversale descriptive, basée sur un échantillon clinique de 44 patients de TB âgés de 12 à 19 ans, appariés selon l’âge et le sexe avec 44 témoins en santé (TS). La psychopathologie a été déterminée à l’aide de KSADS-PL, en plus des échelles cliniques. L’information sur le rendement scolaire antérieur était incluse de même que le résultat fonctionnel basé sur l’échelle d’évaluation globale du fonctionnement pour les enfants (CGAS). L’exposition précédente à des expériences stressantes a été évaluée à l’aide de l’échelle des événements stressants de la vie (SLES). Toutes les analyses ont été menées à l’aide de modèles de régression logistique conditionnelle ou séquentielle.Une fois stabilisés, et même après contrôle des différences sociodémographiques, les patients de TB ont été associés à des niveaux plus faibles de fonctionnalité [RC 0,65 (0,46, 0,93), p = 0,02], et à un rendement scolaire plus mauvais [RC 0,03 (0,01, 0,67), p = 0,03] comparé aux TS. Une psychose sous-syndromale persistante présentait la corrélation négative la plus forte avec la fonctionnalité (rho =−0,65, −0,57 pour TB et TS respectivement; p0,001). Bien que le TB soit associé à des événements plus stressants, cette association ne demeurait pas significative dans les modèles multivariés.La taille modeste de l’échantillon limite notre capacité de détecter les différences entre les groupes, et entre les sous-types de TB.Même lorsque la détection et l’intervention précoces sont fournies, le TB a un effet significatif sur le fonctionnement et sur le rendement scolaire. Il est important de prendre en compte les symptômes de sous-seuil persistants et de mettre l’accent sur les composantes sociale et de rétablissement du traitement.
Published: 2019

106. Lifetime psychopathology in child and adolescent offspring of parents diagnosed with schizophrenia or bipolar disorder: a 2-year follow-up study

Author: Gisela Sugranyes, Dolores Moreno, Vanessa Sánchez-Gistau, E. De la Serna, Soledad Romero, Immaculada Baeza, Ana Espliego, Elisa Rodríguez-Toscano, Miriam Ayora, D. Ilzarbe, and Josefina Castro-Fornieles
Subjects: Male, medicine.medical_specialty, Bipolar Disorder, Time Factors, Adolescent, Offspring, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, mental disorders, Developmental and Educational Psychology, Child and adolescent psychiatry, medicine, Humans, 0501 psychology and cognitive sciences, Bipolar disorder, Psychiatry, Child, Psychopathology, business.industry, 05 social sciences, Follow up studies, General Medicine, medicine.disease, Comorbidity, 030227 psychiatry, Psychiatry and Mental health, Mood disorders, Schizophrenia, Pediatrics, Perinatology and Child Health, Female, business, 050104 developmental & child psychology, Follow-Up Studies
Abstract: Having one parent diagnosed with a severe mental disorder is considered one of the main risk factors for developing that disorder in adulthood, and it also increases the risk of a wide range of mental disorders in the offspring. The aim of this study is to compare the prevalence of several psychopathological diagnoses, the presence of prodromal symptoms, and global functioning in offspring of parents with schizophrenia or bipolar disorder and in offspring of controls at baseline and 2-year follow-up. This study included 41 offspring of parents with schizophrenia, 90 offspring of parents with bipolar disorder, and 107 offspring of controls (mean age 11.7 ± 3.2 at baseline and 13.9 ± 3.2 at follow-up). The prevalence of psychopathology and comorbidity was higher in offspring of parents with schizophrenia and offspring of parents with bipolar disorder than in offspring of controls at baseline and at 2-year follow-up. Interestingly, mood disorders were more prevalent in offspring of parents with bipolar disorder and disruptive disorders were more prevalent in offspring of parents with schizophrenia. Prodromal symptoms were more frequent in offspring of parents with schizophrenia than in offspring of controls, while the offspring of parents with bipolar disorder showed an intermediate pattern. Finally, global functioning was lower in the offspring of parents with schizophrenia than the offspring of parents with bipolar disorder and the offspring of controls. Screening patients’ children is clinically relevant, since, as a group, they have an elevated risk of developing a psychiatric disorder and of experiencing their first symptoms during childhood and adolescence.
Published: 2019

107. Sleep alterations in pediatric bipolar disorder versus attention deficit disorder

Author: Soledad Romero, Ester Camprodon-Rosanas, Santiago Batlle-Vila, Luis Miguel Martín-López, Matilde Elices, Xavier Estrada-Prat, Víctor Pérez, Ion Álvarez-Guerrico, and Enric Álvarez
Subjects: Male, Pediatrics, medicine.medical_specialty, Bipolar Disorder, Adolescent, Bipolar disorder, Polysomnography, Sleep, REM, Attention deficit hyperactivity disorder, 03 medical and health sciences, 0302 clinical medicine, mental disorders, medicine, Humans, Child, Biological Psychiatry, N2 stage, medicine.diagnostic_test, business.industry, Attention deficit disorder, medicine.disease, Sleep in non-human animals, 030227 psychiatry, Pediatric bipolar disorder, Psychiatry and Mental health, Cross-Sectional Studies, Attention Deficit Disorder with Hyperactivity, REM, Attention deficit, Female, Sleep Stages, Sleep, business, 030217 neurology & neurosurgery, Sleep duration
Abstract: Bipolar disorder (BD) and attention deficit/hyperactivity disorder (ADHD) share numerous clinical features, which can make the differential diagnosis challenging. Studies conducted in adults suggest that patients with BD and ADHD have different sleep patterns. However, in pediatric populations, data on these potential differences are scant. The present preliminary study was conducted to identify potential differences in sleep alterations among youths diagnosed with BD or ADHD compared to healthy controls (HC). A total of 26 patients diagnosed with BD (n?=?13) or ADHD (n?=?13) were compared to 26 sex- and age-matched HC ([HC(BD)], n?=?13, and [HC(ADHD)], n?=?13). All participants underwent polysomnography. The mean duration of stage N2 sleep was shorter in the BD group than in controls (HC(BD)). The BD group also had higher (non-significant) REM density (REMd) scores than controls while mean REMd scores were lower in the ADHD group versus controls. Compared to the ADHD group, the BD group presented a shorter N2 stage, a longer first REM sleep duration (R1), and greater REMd. According to our findings, these three variables-N2 stage, REMd, and R1-appear to differentiate patients with BD from those with ADHD and from HC.
Published: 2019

108. Adapted Dialectical Behavior Therapy for Adolescents with a High Risk of Suicide in a Community Clinic: A Pragmatic Randomized Controlled Trial

Author: Astrid Morer, Roger Borràs, Michele S. Berk, Marisol Picado, Pilar Santamarina-Perez, Elena Moreno, Esteve Martínez, Manpreet K. Singh, Elena Font, Soledad Romero, Alexandra Cosi, and Iria Mendez
Subjects: Suicide Prevention, 050103 clinical psychology, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Poison control, Suicide, Attempted, Suicide prevention, Ambulatory Care Facilities, Dialectical Behavior Therapy, law.invention, Suicidal Ideation, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Rating scale, Behavior Therapy, medicine, Outpatient clinic, Humans, 0501 psychology and cognitive sciences, Child, Suicidal ideation, business.industry, 05 social sciences, Public Health, Environmental and Occupational Health, Dialectical behavior therapy, 030227 psychiatry, Psychiatry and Mental health, Clinical Psychology, Treatment Outcome, Community health, Physical therapy, medicine.symptom, business, Self-Injurious Behavior
Abstract: Objective This study is a pragmatic randomized controlled trial, which compares the effectiveness of an adapted form of Dialectical Behavior Therapy for Adolescents (DBT-A) and treatment as usual plus group sessions (TAU + GS) to reduce suicidal risk for adolescents in a community health mental clinic. Method Thirty-five adolescents from a community outpatient clinic, with repetitive NSSI alone or with SA over the last 12 months and with current high suicide risk as assessed by the Columbia-Suicide Severity Rating Scale (C-SSRS), were enrolled. Participants were randomly assigned to undergo either DBT-A (n = 18) or TAU + GT (n = 17) treatments over a 16-week period. Primary outcomes were the difference between NSSI and SA recorded during the first 4 weeks and the final 4 weeks of treatment. Secondary outcomes included changes in Children's Global Assessment Scale (C-GAS), Suicidal Ideation Questionnaire (SIQ-JR), and Beck Depression Inventory-II (BDI-II). Results Dialectical Behavior Therapy for Adolescents was more effective than TAU + GS at reducing NSSI, use of antipsychotics, and improving C-GAS. No SAs were reported in the two groups at the end of the treatment. Both treatments were equally effective in decreasing SIQ-JR and BDI-II scores. Conclusions These findings support the feasibility and effectiveness of DBT-A for adolescents at high risk of suicide in community settings.
Published: 2018

109. Morphological and molecular characterization of larval digenean trematodes (Parvatrema: Gymnophallidae) and their pathological effects on the clam Leukoma thaca (=Protothaca thaca) (Bivalvia:Veneridae) (Molina, 1782) from northern Chile

Author: Diana Montenegro, María Soledad Romero, and María Teresa González
Subjects: 0301 basic medicine, 030231 tropical medicine, Zoology, DNA, Ribosomal, 03 medical and health sciences, 0302 clinical medicine, parasitic diseases, Animals, Metacercariae, Cercaria, Chile, Internal transcribed spacer, Larva, Leukoma, biology, Intermediate host, Veneridae, DNA, Helminth, 030108 mycology & parasitology, Ribosomal RNA, Bivalvia, biology.organism_classification, Infectious Diseases, Genetic distance, Microscopy, Electron, Scanning, Parasitology, Trematoda
Abstract: Trematodes are one of the largest taxa of mollusk parasites. The clam Leukoma thaca is an economically exploited bivalve found along the south-eastern Pacific coast of Peru and Chile. This bivalve is parasitized by various unidentified larval stages of digeneans in the mantle, gonads and digestive gland. The aims of this study were to determine and describe the different larval stages of the digeneans based on morphological characteristics, to identify them at the species level by performing molecular analyses, and to evaluate pathologies associated with the parasites of this clam. Individuals of L. thaca were collected in San Jorge Bay (23°S), Chile, between November 2018 and February 2019. Morphological description was carried out using in vivo and fixed specimens, and analyses including histological and scanning electron microscopy were performed. Individuals were also isolated for molecular analysis using nuclear ribosomal internal transcribed spacer 1 (ITS1), including partial subunit 18S rDNA (18S) and small subunit 5.8S gene (5.8S). Morphological characteristics indicated that the metacercaria larval stage belongs to the family Gymnophallidae, genus Parvatrema, which was supported by molecular analysis. Molecular results revealed that metacercaria, sporocysts and cercaria stages found in this clam belong to the same species of Parvatrema (genetic distance 0%), evidencing that this species uses L. thaca as the first and second intermediate host. Pathologies examined in the host were similar in nature to those reported in other gymnophallids in bivalves, but high prevalence of cercariae (20%) in gonads suggested an important castrator effect on the host.
Published: 2021

110. Association of CACNA1C and SYNE1 in offspring of patients with psychiatric disorders

Author: Sergi Mas, Natalia Rodríguez, Gisela Sugranyes, Patricia Gassó, Soledad Romero, Josefina Castro-Fornieles, Amalia Lafuente, Daniel Boloc, Vanessa Sánchez-Gistau, Dolores Moreno, Covadonga M. Díaz-Caneja, Elena de la Serna, and Carmen Moreno
Subjects: Male, 0301 basic medicine, Heterozygote, medicine.medical_specialty, Candidate gene, Bipolar Disorder, Calcium Channels, L-Type, Genotype, Offspring, Nerve Tissue Proteins, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, Risk Factors, Humans, Medicine, Bipolar disorder, Family history, Child, Psychiatry, Alleles, Genetic Association Studies, Biological Psychiatry, business.industry, Homozygote, Nuclear Proteins, medicine.disease, Pedigree, Genotype frequency, Minor allele frequency, Cytoskeletal Proteins, Psychiatry and Mental health, Logistic Models, 030104 developmental biology, Schizophrenia, Case-Control Studies, Multivariate Analysis, Female, business, 030217 neurology & neurosurgery
Abstract: Schizophrenia (SZ) and bipolar disorder (BD) are severe mental diseases associated with cognitive impairment, mood disturbance, and psychosis. Both disorders are highly heritable and share a common genetic background. The present study assesses, for the first time, differences in genotype frequencies of polymorphisms located in genes involved in neurodevelopment and synaptic plasticity between genetic high-risk individuals (offspring of patients with SZ or BD; N=100: 31 and 69, respectively) and control subjects (offspring of community controls; N=96). Individuals from both groups had similar ages, around 12 years. A higher percentage of men were included in the genetic high-risk group (58%) compared with the control group (40.6%). A total of 244 validated SNPs located in 35 candidate gene regions were analyzed in 196 participants. Multivariate methods based on logistic regression analysis were performed to assess differences in genotype frequencies. Bonferroni correction was applied for the multiple comparisons performed. Two polymorphisms, CACNA1C rs10848683 and SYNE1 rs214950, showed significant differences. The frequency of heterozygotes for CACNA1C rs10848683 in genetic high-risk individuals was double that in controls (OR=3.15; P=0.00016). For SYNE1 rs214950, higher frequencies of heterozygotes (OR=1.97) and homozygotes for the minor allele (OR=17.89; P=0.00020) were found in the genetic high-risk group than in the control group. In conclusion, polymorphisms in CACNA1C and SYNE1 could confer a greater risk of developing SZ and BD in individuals who are already at high risk because of their family history. This could help identify subjects with a very high genetic risk, in whom early detection and early intervention could lead to better prognosis.
Published: 2016

111. Neuropsychological characteristics of child and adolescent offspring of patients with bipolar disorder

Author: Gisela Sugranyes, Elisa Rodríguez-Toscano, Vanessa Sánchez-Gistau, Soledad Romero, Teresa Sánchez-Gutiérrez, Elena de la Serna, Monserrat Vila, Josefina Castro-Fornieles, Cloe Llorente, Immaculada Baeza, and Dolores Moreno
Subjects: Male, medicine.medical_specialty, Bipolar Disorder, Adolescent, Offspring, Intelligence, Neuropsychological Tests, Executive Function, 03 medical and health sciences, Cognition, 0302 clinical medicine, Child of Impaired Parents, Visual memory, Memory, medicine, Humans, Attention, Longitudinal Studies, Bipolar disorder, Child, Psychiatry, Biological Psychiatry, Intelligence Tests, Pharmacology, Working memory, medicine.disease, Executive functions, 030227 psychiatry, Memory, Short-Term, Schizophrenia, Female, Verbal memory, Psychology, 030217 neurology & neurosurgery, Psychopathology
Abstract: Background Bipolar disorder (BD) is a severe mental disorder with a strong genetic component. The assessment of child and adolescent offspring of patients diagnosed with BD (BDoff) provides an opportunity to investigate vulnerability factors and the first abnormalities associated with the disorder. Previous literature in child and adolescent BDoff is scarce and controversial. However, some studies concur in identifying significant impairment in executive functions, memory and attention. The present study aims to compare global neuropsychological characteristics of child and adolescent offspring of patients with bipolar disorder with a group of offspring of parents with no history of psychotic disorder, and to assess the influence of psychopathology on neuropsychological performance. Methods This research was part of The Bipolar and Schizophrenia Young Offspring Study (BASYS). A group of BDoff (N = 90) and a group of offspring of parents with no history of psychotic disorder (CC) (N = 107) were assessed with a complete neuropsychological battery. Intellectual quotient, working memory, processing speed, verbal memory and learning, visual memory, attention and executive functions were included in the cognitive assessment. Results BDoff showed significantly worse performance in processing speed and immediate recall of visual memory relative to CC. When the presence of any lifetime psychopathology was analysed, the results showed that belonging to the BDoff group was the main explicative factor for the scores obtained in both processing speed and visual memory immediate recall, regardless of the presence of psychopathology. Conclusions These findings suggest that processing speed and visual memory should be taken into consideration in future research on vulnerability markers of BD.
Published: 2016

112. P.857Cognitive reserve in child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder

Author: P. Camprobon-Boadas, E. De la Serna, Immaculada Baeza, Laura Montejo, Soledad Romero, Josefina Castro-Fornieles, Mireia Rosa-Justicia, D. Ilzarbe, Carla Torrent, G. Sugranyes, and Brisa Solé
Subjects: Pharmacology, medicine.medical_specialty, business.industry, Offspring, medicine.disease, Child and adolescent, Psychiatry and Mental health, Neurology, Schizophrenia, medicine, Pharmacology (medical), Neurology (clinical), Bipolar disorder, Psychiatry, business, Biological Psychiatry
Published: 2020

113. 32.2 CHANGES IN VISUAL MEMORY IN ADOLESCENTS AT HIGH RISK FOR SUICIDE WHO RESPOND TO PSYCHOTHERAPY

Author: Pilar Santamarina, Iria Mendez, Marisol Picado, Elena Font, Elena Moreno, Esteve Martínez, Astrid Morer, Cordovilla Carlos, and Soledad Romero
Subjects: Psychiatry and Mental health, Developmental and Educational Psychology
Published: 2020

114. S169. THE IMPACT OF PSYCHOSIS IN ADOLESCENT-ONSET BIPOLAR DISORDER: A STRUCTURAL MRI STUDY

Author: Adriana Fortea, Nestor Arbelo, Gisela Sugranyes, Inmaculada Baeza, Soledad Romero, Sara Lera, Isabel Valli, Lidia Ilzarbe, Iria Mendez, Josefina Castro-Fornieles, and Cristian Llach
Subjects: Psychiatry and Mental health, Psychosis, medicine.medical_specialty, Poster Session I, Adolescent onset, AcademicSubjects/MED00810, business.industry, Medicine, Bipolar disorder, business, medicine.disease, Psychiatry
Abstract: Background Bipolar Disorder (BD) is a major psychiatric illness defined by episodic mood changes, which in approximately 50% of cases is associated with psychotic features. Over the past decades, a large amount of research has identified brain structural and functional alterations in patients with this mental disorder. Some findings have been found to be specific to patients with psychotic symptoms, raising suggestions that this could represent a biological subtype of the disorder. Recent interest has been addressed to Early-Onset Bipolar Disorder (EOBD, onset prior to age 18). Latest reviews in EOBD samples have pointed to abnormalities in the frontal lobe and limbic structures, with some inconsistencies in the reported results possibly caused by differences in the methodology. In addition, no study so far has examined the neural structural correlates of psychotic symptoms in adolescent-onset bipolar disorder (AOBD). The aim of the present study is to examine the impact of psychosis on the neurobiological architecture in a sample of patients with AOBD. To our knowledge, this is the first study comparing gray matter structure between AOBD patients with or without psychotic features. Methods We conducted a cross-sectional study collecting T1-weighted structural magnetic resonance neuroimaging (3T-MRI) data in patients diagnosed with Bipolar Disorder type I or II between 12 and 19 years old (N=46, mean age (SD)=15.89 (1.94), gender=52.2% females). All patients were recruited from child and adolescent mental health services of the Hospital Clinic of Barcelona, Spain. Diagnoses were confirmed with a semi-structured clinical interview (Kiddie-Sads present and lifetime version) by child and adolescent psychiatrists. Images were pre-processed employing FreeSurfer 5.3.0, and data corresponding to Cortical Thickness (CTH) and Subcortical Volumes (SCV) was obtained. Groups were compared according to whether patients had experienced psychotic symptoms at any point during their illness: Non-Psychotic Bipolar Disorder (NPSBD, N=25) and Psychotic Bipolar Disorder (PSBD, N=21). No differences in age (t=0.498, p=0.621) or sex (χ2=0.001, p=0.979). Group effects in relation to both CT and SCV were examined with a general linear model. The main effect of group on CTH and SCV, was performed for the whole brain, performing a correction for multiple comparisons (Montecarlo correction, threshold = 0.05). Results Between-group analyses showed smaller CTH in a cluster in the left medial orbitofrontal cortex (cluster size= 1142.58 mm2) in PSBD relative to NPSBD (x, y, z: 25.63, 89.61, -42.74; p=0.002). In addition, we observed a smaller right hippocampus volume (p=0.025) in PSBD relative to NPSBD. No other statistically significant differences were obtained. Discussion PSBD showed smaller cortical thickness in the left medial orbitofrontal cortex, as well as a volumetric reduction in the right hippocampal volume. Similar results have been reported in a study comparing adolescent patients with psychotic BD and healthy controls. These results add evidence about the role of these two structures in the genesis of psychotic symptoms in a population diagnosed with AOBD. Interestingly, one study has reported a surface area decreased of the orbitofrontal cortex in adolescent patients with a non-bipolar psychotic disorder, which suggests that they may be a common substrate to psychotic symptoms during adolescence regardless of co-occurring affective symptoms. In summary, this study points to the existence of a distinct biological nature between bipolar patients according to psychotic symptoms, underpinned by a different neurobiological architecture. Future research should focus on replication and on examining the clinical value of this finding.
Published: 2020

115. Baseline neurofunctional predictors of improvement in self-harming behaviors in adolescents before and after group therapy

Author: Iria Mendez, Pilar Santamarina Pérez, and Soledad Romero
Published: 2018

116. LOCAL INFILTRATION ANAESTHESIA AND TRANEXAMIC ACID REDUCING BLOOD LOSS AND TRANSFUSION REQUERIMENTS IN TOTAL KNEE ARTHROPLASTY

Author: Carolina Soledad Romero Garcia
Published: 2018

117. La autonomía emocional en el profesorado de secundaria. Análisis en el marco de un proceso de coaching personal//Emotional autonomy in secondary teachers. Analysis in the framework of a life coaching process

Author: José Manuel Huertas-Fernández and Soledad Romero-Rodríguez
Subjects: Applied Psychology, Education
Abstract: RESUMEN Cada vez somos mas conscientes del amplio espectro de emociones que se viven en los centros educativos. Existe multitud de trabajos cientificos que evidencian la necesidad de incorporar programas de educacion emocional en dichos centros. Nos planteamos una investigacion que tiene como objetivo identificar los factores que influyen en el desarrollo de la Autonomia emocional del profesorado. El diseno metodologico que seguimos tiene un enfoque mixto. La recogida de datos cuantitativos se ha realizado a traves del cuestionario de desarrollo emocional CDE A-35, administrado a una muestra de 352 docentes de Andalucia. Como procedimientos cualitativos se han realizado entrevistas autobiograficas que incorporan tecnicas y herramientas del coaching personal a 7 de estos docentes. Los resultados de la investigacion muestran que los factores que potencian la Autonomia emocional del profesorado son la vocacion docente y la relacion con los iguales y con el alumnado . Los factores que la limitan son los miedos personales y la dificultad para planificarse . Como conclusiones, se han identificado los factores que influyen en el desarrollo de la Autonomia emocional y en los que se deberia centrar una futura intervencion. Asimismo, se ha observado que el proceso de coaching personal ha servido para que el profesorado tome conciencia de sus necesidades de formacion emocional. ABSTRACT We are increasingly aware of the broad spectrum of emotions that are experienced in schools. Experience and scientific literature provide evidence that supports the need for emotional education programs in schools. The main objective of our investigation is to identify the factors that influence the development of the teachers’ emotional autonomy. The methodological design we follow has a mixed approach. Quantitative data collection has been obtained from the emotional development questionnaire CDE A-35 v. 3, administered to a sample of 352 teachers from Andalusia and the qualitative autobiographical interviews with 7 of these teachers that incorporate Life Coaching tools and techniques. The results of the research show that the factors that enhance emotional autonomy are the teaching vocation and the relationship with peers and students . Those that reveal limitations in relation to this autonomy are personal fears and planning difficulty . In conclusion, the factors that influence the development of emotional Autonomy have been identified, on which a future intervention should focus. Likewise, it has been observed that the process of Life Coaching is useful to make teachers aware of their emotional training needs.
Published: 2019

118. Activation in Children and Adolescents Treated With Selective Serotonin Reuptake Inhibitors: A Weighty Reason?

Author: Marta García, Eva Varela, Astrid Morer, Soledad Romero, Blanca Garcia-Delgar, Luisa Lázaro, and Barbara J. Coffey
Subjects: Male, Pediatrics, medicine.medical_specialty, Adolescent, Psychotropic medication, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Medicine, Humans, Pharmacology (medical), Adverse effect, Child, Retrospective Studies, business.industry, Body Weight, Serotonin reuptake, Irritable Mood, 030227 psychiatry, Psychiatry and Mental health, Treatment Outcome, Neurodevelopmental Disorders, Female, High incidence, business, Self-Injurious Behavior, 030217 neurology & neurosurgery, Selective Serotonin Reuptake Inhibitors, Akathisia, Drug-Induced, Follow-Up Studies
Abstract: Activation is a behavioral adverse event related to the use of psychotropic medication. Its high incidence in pediatrics and in childhood-onset neuropsychiatric disorders suggests it may be linked to neurodevelopment. However, previous studies have scarcely examined the role that factors relevant to developmental pharmacokinetics, such as body weight, may play in the onset of activation in children and adolescents.We conducted a retrospective analysis of hospitalized patients to identify the risk factors for activation in children and adolescents treated with selective serotonin reuptake inhibitors. Our focus was on factors related to development, including body weight, to explore the relationship between activation and neurodevelopmental processes.Among the 139 participants (mean age, 14 ± 2.3 years), activation appeared in 29 (20.9%). Age 12 years or younger and comorbid diagnosis of autism spectrum disorder were associated with statistically significant increases in the risk of activation, but no association was found regarding body weight.Our findings support the hypothesis that activation is closely linked to brain development processes. Longitudinal studies are needed to explore this line of research further.
Published: 2018

119. Duración de la supresión viral en pacientes con VIH en terapia antiretroviral en Perú: análisis de sobrevida acumulada 2004-2012

Author: Soledad Romero Ruiz, Julia Rosa Piscoya Sara, Cristian Obregón Cahuayo, Jorge O. Alarcón Villaverde, Patricia Caballero Ñopo, Nora Reyes Puma, and Gustavo Alonso Urbano Quispe
Subjects: Medicine (General), Survival, HIV, VIH, Therapeutics, Perú, R5-920, Peru, Sobrevida, Medicine, General Earth and Planetary Sciences, Tratamiento, General Environmental Science
Abstract: Introducción. El objetivo primordial de los programas nacionales es la supresión de la replicación viral hasta niveles indetectables y el sostenimiento de esta respuesta virológica a lo largo del tiempo. El objetivo del estudio fue analizar la duración de la supresión viral en pacientes adultos con VIH que iniciaron tratamiento antiretroviral en el Perú durante el periodo 2004-2006 con seguimiento hasta el 2012 mediante análisis de sobrevida acumulada. Métodos. Se realizó un estudio observacional retrospectivo realizado en base a la cohorte histórica de pacientes que accedieron al programa nacional de tratamiento antirretroviral durante el periodo 2004 al 2006 en el Perú y que tuvo seguimiento hasta el 31 de diciembre del 2012. Resultados. Del total de 6289 pacientes, 5142(81,7%) iniciaron algún esquema de tratamiento y 4530(72%) alcanzaron supresión viral, la cual se sostuvo por tiempo variable durante el periodo de observación. Según la tasa de sobrevida acumulada el 91,1% mantuvieron supresión viral hasta 1 año, 84,6% hasta 2 años, 80,2% hasta 3 años, 77,1% hasta 4 años, 74,1% hasta 5 años y 70,1% hasta 6 años. Conclusiones. La cohorte peruana que empezó el tratamiento antirretroviral en la etapa inicial de implementación del programa nacional, presentó duración de supresión viral sostenida con tasas comparables o por encima a otros países latinoamericanos. La duración de la supresión viral es indicador longitudinal del desempeño de los programas nacionales y locales, que puede contribuir a estimar la duración del uso de un solo tipo de esquema de terapia antiretroviral y validar adherencia. Introduction. The primary objective of national programs is the suppression of viral replication to undetectable levels and the sustaining of this virological response over time. The objective of the study was to analyze the duration of viral suppression in adult patients with HIV who started antiretroviral treatment in Peru during the period 2004-2006 with follow-up until 2012 using cumulative survival rate analysis. Methods. A retrospective observational study was conducted based on the historical cohort of patients who linked to the antiretroviral treatment national program during the period 2004 to 2006 in Peru with follow-up until December 31st, 2012. Results. Of the 6289 patients, 5142 (81.7%) initiated some treatment scheme and 4530 (72%) reached viral suppression which was sustained by variable time during the observation period. According to the cumulative survival rate 91.1% sustained viral suppression up to 1 year, 84.6% up to 2 years, 80.2% up to 3 years, 77.1% up to 4 years, 74.1% up to 5 years and 70.1% up to 6 years. Conclusions. The Peruvian cohort that began antiretroviral treatment in the initial phase of implementation of the national program, presented comparable results or above other Latin American countries in the duration of sustained viral suppression. The duration of viral suppression is a longitudinal indicator of the performance of national and local programs, which could also help to estimate the time of use of the therapeutic schemes of antiretrovirals and validate adherence.
Published: 2018

120. La Alianza del Pacífico, el Reto y la Respuesta

Author: Rocío Arley Tapullima Salviati, Eloy Manuel Durán Durand, Beatriz Joaquina Villacrez Peña, Karina Soledad Romero Revilla, Keila Del Rocío Vargas Chirinos, Verónica Brigitte Miller Verano, David Joseph Castañeda Varillas, Xiomara Vanessa Huerta Zuñiga, and Valery Cristhel Viacava Alarcón
Subjects: libre comercio, Derecho, barreras no arancelarias, Alianza del Pacífico, General Earth and Planetary Sciences, aranceles, comercio internacional, Asia-Pacífico, General Environmental Science
Abstract: La investigación profundiza en el conocimiento de la Alianza del Pacífico y explica con detalle los acuerdos comerciales que han adoptado sus miembros a fin de liberalizar el comercio de bienes y servicios en el bloque. Analiza estas medidas a la luz de las oportunidades comerciales que esta liberalización promete. La investigación establece que incluso considerando la baja interdependencia económica de los miembros de la Alianza del Pacífico y aun a pesar de que la integración económica al interior del bloque termina teniendo connotaciones más formales que reales; la posibilidad tangible de desarrollar cadenas productivas mirando a los mercados asiáticos exhibe a la Alianza del Pacífico como un mecanismo importante para conseguir tanto crecimiento económico como desarrollo social This paper explores the Pacific Alliance trying to explain the binding agreements that its members have adopted in order to liberalize the trade of goods and services within the block. It analyses these agreements, considering the potential trade opportunities that such a liberalization process promises. The research states that even considering the poor levels of economic interdependence among the members of the Pacific Alliance and despite the fact that economic integration inside the block has more formal than real connotations; the true chance of developing value chains for the Asian markets presents the Pacific Alliance as an important tool in order to obtain both economic growth and social development
Published: 2018

121. Chemical Synthesis and Functional Analysis of VarvA Cyclotide

Author: Constanza Cárdenas, Paula A. Santana, Claudio Alvarez, Fanny Guzmán, Omar F. Luna, María Soledad Romero, and Fernando Albericio
Subjects: 0301 basic medicine, cyclotide, antimicrobial activity, fish pathogens, membrane damage, 030106 microbiology, Pharmaceutical Science, Peptide, Cyclotides, Chemical synthesis, Flavobacterium, Article, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, chemistry.chemical_compound, lcsh:Organic chemistry, Anti-Infective Agents, Drug Discovery, Gram-Negative Bacteria, Peptide synthesis, Physical and Theoretical Chemistry, Peptide sequence, chemistry.chemical_classification, biology, Organic Chemistry, biology.organism_classification, Antimicrobial, Cyclotide, 030104 developmental biology, chemistry, Biochemistry, Chemistry (miscellaneous), Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Molecular Medicine, Bacteria
Abstract: Cyclotides are circular peptides found in various plant families. A cyclized backbone, together with multiple disulfide bonds, confers the peptides’ exceptional stability against protease digestion and thermal denaturation. In addition, the features of these antimicrobial molecules make them suitable for use in animal farming, such as aquaculture. Fmoc solid phase peptide synthesis on 2-chlorotrityl chlorine (CTC) resin using the “tea-bag” approach was conducted to generate the VarvA cyclotide identified previously from Viola arvensis. MALDI-TOF mass spectrometry determined the correct peptide amino acid sequence and the cyclization sites-critical in this multicyclic compound. The cyclotide showed antimicrobial activity against various Gram-negative bacteria, including recurrent pathogens present in Chilean aquaculture. The highest antimicrobial activity was found to be against Flavobacterium psychrophilum. In addition, membrane blebbing on the bacterial surface after exposure to the cyclotide was visualized by SEM microscopy and the Sytox Green permeabilization assay showed the ability to disrupt the bacterial membrane. We postulate that this compound can be proposed for the control of fish farming infections.
Published: 2018

122. Identification of Peptides in Flowers of

Author: Claudio Andrés, Álvarez, Andrés, Barriga, Fernando, Albericio, María Soledad, Romero, and Fanny, Guzmán
Subjects: antimicrobial activity, fish pathogens, Fishes, Aquaculture, Blood Proteins, Flowers, Mass Spectrometry, Article, Molecular Weight, Sambucus nigra, S. nigra, membrane damage, Gram-Negative Bacteria, peptides, Animals, Amino Acid Sequence, Antimicrobial Cationic Peptides
Abstract: The elder (Sambucus spp.) tree has a number of uses in traditional medicine. Previous studies have demonstrated the antimicrobial properties of elderberry liquid extract against human pathogenic bacteria and also influenza viruses. These properties have been mainly attributed to phenolic compounds. However, other plant defense molecules, such as antimicrobial peptides (AMPs), may be present. Here, we studied peptide extracts from flowers of Sambucus nigra L. The mass spectrometry analyses determined peptides of 3 to 3.6 kDa, among them, cysteine-rich peptides were identified with antimicrobial activity against various Gram-negative bacteria, including recurrent pathogens of Chilean aquaculture. In addition, membrane blebbing on the bacterial surface after exposure to the cyclotide was visualized by SEM microscopy and SYTOX Green permeabilization assay showed the ability to disrupt the bacterial membrane. We postulate that these peptides exert their action by destroying the bacterial membrane.
Published: 2018

123. The surgical safety checklist and patient outcomes after surgery

Author: T.E.F. Abbott, T. Ahmad, M.K. Phull, A.J. Fowler, R. Hewson, B.M. Biccard, M.S. Chew, M. Gillies, R.M. Pearse, Rupert M. Pearse, Scott Beattie, Pierre-Alain Clavien, Nicolas Demartines, Lee A. Fleisher, Mike Grocott, James Haddow, Andreas Hoeft, Peter Holt, Rui Moreno, Naomi Pritchard, Andrew Rhodes, Duminda Wijeysundera, Matt Wilson, Tahania Ahmed, Kirsty Everingham, Russell Hewson, Marta Januszewska, Mandeep-Kaur Phull, Richard Halliwell, Mark Shulman, Paul Myles, Werner Schmid, Michael Hiesmayr, Patrick Wouters, Stefan de Hert, Suzana Lobo, Xiangming Fang, Lars Rasmussen, Emmanuel Futier, Matthieu Biais, Aurélien Venara, Karem Slim, Michael Sander, Despoina Koulenti, Kostoula Arvaniti, Mathew Chan, Atul Kulkarni, Susilo Chandra, Aida Tantri, Emad Geddoa, Muntadhar Abbas, Giorgio Della Rocca, Datin Sivasakthi, Marzida Mansor, Pastor Luna, Arthur Bouwman, Wolfgang Buhre, Vanessa Beavis, Douglas Campbell, Tim Short, Tunde Osinaike, Ricardo Matos, Ioana Grigoras, Mikhail Kirov, Denis Protsenko, Bruce Biccard, Cesar Aldecoa, Michelle Chew, Christoph Hofer, Martin Hubner, James Ditai, Tamas Szakmany, Lee Fleisher, Marissa Ferguson, Michael MacMahon, Ritchie Cherian, Helen Currow, Kathirgamanathan Kanathiban, David Gillespie, Edward Pathmanathan, Katherine Phillips, Jenifer Reynolds, Joanne Rowley, Jeanene Douglas, Ross Kerridge, Sameer Garg, Michael Bennett, Megha Jain, David Alcock, Nico Terblanche, Rochelle Cotter, Kate Leslie, Marcelle Stewart, Nicolette Zingerle, Antony Clyde, Oliver Hambidge, Adam Rehak, Sharon Cotterell, Wilson Binh Quan Huynh, Timothy McCulloch, Erez Ben-Menachem, Thomas Egan, Jennifer Cope, Paul Fellinger, Markus Haisjackl, Simone Haselberger, Caroline Holaubek, Paul Lichtenegger, Florian Scherz, Franz Hoffer, Veronika Cakova, Andreas Eichwalder, Norbert Fischbach, Reinhold Klug, Elisabeth Schneider, Martin Vesely, Reinhart Wickenhauser, Karl Gernot Grubmueller, Marion Leitgeb, Friedrich Lang, Nancy Toro, Marlene Bauer, Friedrich Laengle, Claudia Haberl, Thomas Mayrhofer, Christoph Trybus, Christian Buerkle, Karin Forstner, Reinhard Germann, Harald Rinoesl, Elke Schindler, Ernst Trampitsch, Gerhard Bogner, Daniel Dankl, Martin Duenser, Gerhard Fritsch, Ilse Gradwohl-Matis, Andreas Hartmann, Thomas Hoelzenbein, Tarkan Jaeger, Franz Landauer, Gregor Lindl, Michael Lux, Johannes Steindl, Ottokar Stundner, Christian Szabo, Jawad Bidgoli, Hans Verdoodt, Patrice Forget, David Kahn, Fernande Lois, Mona Momeni, Caroline Prégardien, Audrey Pospiech, Arnaud Steyaert, Laurent Veevaete, Dirk De Kegel, Karen De Jongh, Luc Foubert, Carine Smitz, Marcel Vercauteren, Jan Poelaert, Veerle Van Mossevelde, Jacques Abeloos, Stefaan Bouchez, Marc Coppens, Luc De Baerdemaeker, Isabel Deblaere, Ann De Bruyne, Kristine Fonck, Bjorn Heyse, Tom Jacobs, Koen Lapage, Anneliese Moerman, Martine Neckebroek, Aliaksandra Parashchanka, Nathalie Roels, Nancy Van Den Eynde, Michael Vandenheuvel, JurgenVan Limmen, Ann Vanluchene, Caroline Vanpeteghem, Piet Wyffels, Christel Huygens, Punitha Vandenbempt, Marc Van de Velde, Dimitri Dylst, Bruno Janssen, Evelien Schreurs, Fábia Berganton Aleixo, Keulle Candido, Hugo Dias Batista, Mario Guimarães, Jaqueline Guizeline, João Hoffmann, Francisco Ricardo Marques Lobo, Vinícius Nascimento, Katia Nishiyama, Lucas Pazetto, Daniela Souza, Rodrigo Souza Rodrigues, Ana Maria Vilela dos Santos, Jaquelline Jardim, Luiz Marcelo Sá Malbouisson, Joao Silva, Paulo do Nascimento Junior, Thalissa Hermínia Baio, Gabriel Isaac Pereira de Castro, Henri Roger Watanabe Oliveira, Cristina Prata Amendola, Gutemberg Cardoso, Daniela Ortega, Ana Flavia Brotto, Mirella Cristine De Oliveira, Álvaro Réa-Neto, Fernando Dias, Maria Eduarda Travi, Luiza Zerman, Pedro Azambuja, Marcos Freitas Knibel, Antonio Martins, William Almeida, Calim Neder Neto, Maria Angela Tardelli, Eliana Caser, Marcio Machado, Crisitiano Aguzzoli, Sérgio Baldisserotto, Fernanda Beck Tabajara, Fernanda Bettega, La Hore Correa Rodrigues Júnior, Julia de Gasperi, Lais Faina, Marcos Farias Nolasco, Bruna Ferreira da Costa Fischer, Mariana Fosch de Campos Ferreira, Cristina Hartmann, Marta Kliemann, Gustavo Luis Hubert Ribeiro, Julia Merladete Fraga, Thiago Motta Netto, Laura Valduga Pozza, Paulo Rafael Wendling, Caroline Azevedo, Juliana Garcia, Marcel Lopes, Bernardo Maia, Paula Maselli, Ralph Melo, Weslley Mendes, Matheus Neves, Jacqueline Ney, Claudio Piras, Christopher Applewhaite, Adrienne Carr, Lorraine Chow, Kaylene Duttchen, Julena Foglia, Michael Greene, Ashley Hinther, Kendra Houston, Thomas Jared McCormick, Jennifer Mikhayel, Sam Montasser, Alex Ragan, Andrew Suen, Adrianna Woolsey, Hai Chuan Yu, Duane Funk, Stephen Kowalski, Regina Legaspi, Heather McDonald, Faisal Siddiqui, Jeremy Pridham, Bernadette Rowe, Sonia Sampson, Barton Thiessen, Geoff Zbitnew, Andre Bernard, Ronald George, Philip Jones, Rita Moor, Naveed Siddiqui, Alexandra Wolfer, Diem Tran, Denyse Winch, Gary Dobson, Thomas McCormick, Osama Montasser, Richard Hall, Leyla Baghirzada, Gerard Curley, Si Yuan Dai, Gregory Hare, Esther Lee, Uma Shastri, Albert Tsui, Anmol Yagnik, Danielle Alvares, Stephen Choi, Heather Dwyer, Kathrina Flores, Colin McCartney, Priya Somascanthan, Jo Carroll, Janneth Pazmino-Canizares, Noam Ami, Vincent Chan, Anahi Perlas, Ruth Argue, Yang Huang, Katie Lavis, Kelly Mayson, Ying Cao, Hong Gao, Tingju Hu, Jie Lv, Jian Yang, Yang Yang, Yi Zhong, Jing Zhou, Xiaohua Zou, Miao He, Xiaoying Li, Dihuan Luo, Haiying Wang, Tian Yu, Liyong Chen, Lijun Wang, Yunfei Cai, Zhongming Cao, Yanling Li, Jiaxin Lian, Haiyun Sun, Sheng Wang, Zhipeng Wang, Kenru Wang, Yi Zhu, Xindan Du, Hao Fan, Yunbin Fu, Lixia Huang, Yanming Huang, Haifang Hwan, Hong Luo, Pi-Sheng Qu, Fan Tao, Zhen Wang, Guoxiang Wang, Shun Wang, Yan Zhang, Xiaolin Zhang, Chao Chen, Weixing Wang, Zhengyuan Liu, Lihua Fan, Jing Tang, Yijun Chen, Yongjie Chen, Yangyang Han, Changshun Huang, Guojin Liang, Jing Shen, Jun Wang, Qiuhong Yang, Jungang Zhen, Haidong Zhou, Junping Chen, Zhang Chen, Xiaoyu Li, Bo Meng, Haiwang Ye, Xiaoyan Zhang, Yanbing Bi, Jianqiao Cao, Fengying Guo, Hong Lin, Yang Liu, Meng Lv, Pengcai Shi, Xiumei Song, Chuanyu Sun, Yongtao Sun, Yuelan Wang, Shenhui Wang, Min Zhang, Rong Chen, Jiabao Hou, Yan Leng, Qing-tao Meng, Li Qian, Zi-ying Shen, Zhong-yuan Xia, Rui Xue, Yuan Zhang, Bo Zhao, Xian-jin Zhou, Qiang Chen, Huinan Guo, Yongqing Guo, Yuehong Qi, Zhi Wang, Jianfeng Wei, Weiwei Zhang, Lina Zheng, Qi Bao, Yaqiu Chen, Yijiao Chen, Yue Fei, Nianqiang Hu, Xuming Hu, Min Lei, Xiaoqin Li, Xiaocui Lv, Fangfang Miao, Lingling Ouyang, Lu Qian, Conyu Shen, Yu Sun, Yuting Wang, Dong Wang, Chao Wu, Liyuan Xu, Jiaqi Yuan, Lina Zhang, Huan Zhang, Yapping Zhang, Jinning Zhao, Chong Zhao, Lei Zhao, Tianzhao Zheng, Dachun Zhou, Haiyan Zhou, Ce Zhou, Kaizhi Lu, Ting Zhao, Changlin He, Hong Chen, Shasha Chen, Baoli Cheng, Jie He, Lin Jin, Caixia Li, Hui Li, Yuanming Pan, Yugang Shi, Xiao Hong Wen, Shuijing Wu, Guohao Xie, Kai Zhang, Bing Zhao, Xianfu Lu, Feifei Chen, Qisheng Liang, Xuewu Lin, Yunzhi Ling, Gang Liu, Jing Tao, Lu Yang, Jialong Zhou, Fumei Chen, Zhonggui Cheng, Hanying Dai, Yunlin Feng, Benchao Hou, Haixia Gong, Chun hua Hu, Haijin Huang, Jian Huang, Zhangjie Jiang, Mengyuan Li, Jiamei Lin, Mei Liu, Weicheng Liu, Zhen Liu, Zhiyi Liu, Foquan Luo, Longxian Ma, Jia Min, Xiaoyun Shi, Zhiping Song, Xianwen Wan, Yingfen Xiong, Lin Xu, Shuangjia Yang, Qin Zhang, Hongyan Zhang, Huaigen Zhang, Xuekang Zhang, Lili Zhao, Weihong Zhao, Weilu Zhao, Xiaoping Zhu, Yun Bai, Linbi Chen, Sijia Chen, Qinxue Dai, Wujun Geng, Kunyuan Han, Xin He, Luping Huang, Binbin Ji, Danyun Jia, Shenhui Jin, Qianjun Li, Dongdong Liang, Shan Luo, Lulu Lwang, Yunchang Mo, Yuanyuan Pan, Xinyu Qi, Meizi Qian, Jinling Qin, Yelong Ren, Yiyi Shi, Junlu Wang, Junkai Wang, Leilei Wang, Junjie Xie, Yixiu Yan, Yurui Yao, Mingxiao Zhang, Jiashi Zhao, Xiuxiu Zhuang, Yanqiu Ai, Fang Du, Long He, Ledan Huang, Zhisong Li, Huijuan Li, Yetong Li, Liwei Li, Su Meng, Yazhuo Yuan, Enman Zhang, Jie Zhang, Shuna Zhao, Zhenrong Ji, Ling Pei, Li Wang, Chen Chen, Beibei Dong, Jing Li, Ziqiang Miao, Hongying Mu, Chao Qin, Lin Su, Zhiting Wen, Keliang Xie, Yonghao Yu, Fang Yuan, Xianwen Hu, Ye Zhang, Wangpin Xiao, Zhipeng Zhu, Qingqing Dai, Kaiwen Fu, Rong Hu, Xiaolan Hu, Song Huang, Yaqi Li, Yingping Liang, Shuchun Yu, Zheng Guo, Yan Jing, Na Tang, Jie Wu, Dajiang Yuan, Ruilin Zhang, Xiaoying Zhao, Yuhong Li, Hui-Ping Bai, Chun-Xiao Liu, Fei-Fei Liu, Wei Ren, Xiu-Li Wang, Guan-Jie Xu, Na Hu, Bo Li, Yangwen Ou, Yongzhong Tang, Shanglong Yao, Shihai Zhang, Cui-Cui Kong, Bei Liu, Tianlong Wang, Wei Xiao, Bo Lu, Yanfei Xia, Jiali Zhou, Fang Cai, Pushan Chen, Shuangfei Hu, Hongfa Wang, Qiong Xu, Liu Hu, Liang Jing, Bin Li, Qiang Liu, Yuejiang Liu, Xinjian Lu, Zhen Dan Peng, Xiaodong Qiu, Quan Ren, Youliang Tong, Jin Wang, Yazhou Wen, Qiong Wu, Jiangyan Xia, Jue Xie, Xiapei Xiong, Shixia Xu, Tianqin Yang, Hui Ye, Ning Yin, Jing Yuan, Qiuting Zeng, Baoling Zhang, Kang Zheng, Jing Cang, Shiyu Chen, Yu Fan, Shuying Fu, Xiaodong Ge, Baolei Guo, Wenhui Huang, Linghui Jiang, Xinmei Jiang, Yi Liu, Yan Pan, Yun Ren, Qi Shan, Jiaxing Wang, Fei Wang, Chi Wu, Xiaoguang Zhang, Ida Cecilie Christiansen, Simon Nørgaard Granum, Bodil Steen Rasmussen, Morten Daugaard, Rajiv Gambhir, Birgitte Brandsborg, Guðný Erla Steingrímsdóttir, Peter Jensen-Gadegaard, Karsten Skovgaard Olsen, Hanna Siegel, Katrine Zwicky Eskildsen, Mona Ring Gätke, Ida Wibrandt, Simon Bisgaard Heintzelmann, Kai Henrik Wiborg Lange, Rune Sarauw Lundsgaard, Louise Amstrup-Hansen, Claus Hovendal, Michael Larsen, Mette Lenstrup, Tina Kobborg, Jens Rolighed Larsen, Anette Barbre Pedersen, Søren Hübertz Smith, Rebecca Monett Oestervig, Arash Afshari, Cheme Andersen, Kim Ekelund, Erik Lilja Secher, Helene Beloeil, Sigismond Lasocki, Alexandre Ouattara, Marlene Sineus, Serge Molliex, Marie Lim Legouge, Florent Wallet, Antoine Tesniere, Christophe Gaudin, Paul Lehur, Emma Forsans, Stéphane de Rudnicki, Valerie Serra Maudet, Didier Mutter, Ghassan Sojod, Mehdi Ouaissi, Jean-Marc Regimbeau, Jacques Desbordes, Nicolas Comptaer, Diae el Manser, Sabine Ethgen, Gilles Lebuffe, Patrick Auer, Christine Härtl, Maria Deja, Kirill Legashov, Susanne Sonnemann, Carola Wiegand-Loehnert, Elke Falk, Marit Habicher, Stefan Angermair, Beatrix Laetsch, Katrin Schmidt, Christian Von Heymann, Axel Ramminger, Florian Jelschen, Svenja Pabel, Andreas Weyland, Elke Czeslick, Jochen Gille, Michael Malcharek, Armin Sablotzki, Katharina Lueke, Peter Wetzel, Joerg Weimann, Franz-Peter Lenhart, Florian Reichle, Frederike Schirmer, Michael Hüppe, Karl Klotz, Carla Nau, Julika Schön, Thomas Mencke, Christina Wasmund, Carla Bankewitz, Georg Baumgarten, Andreas Fleischer, Vera Guttenthaler, Yvonne Hack, Katharina Kirchgaessner, Olja Männer, Marlen Schurig-Urbaniak, Rafael Struck, Rebekka van Zyl, Maria Wittmann, Ulrich Goebel, Sarah Harris, Siegfried Veit, Evangelia Andreadaki, Flora Souri, Ioannis Katsiadramis, Anthi Skoufi, Maria Vasileiou, Eleni Aimoniotou- Georgiou, Anastasios Katsourakis, Fotini Veroniki, Glyceria Vlachogianni, Konstantina Petra, Dimitra Chlorou, Eirini Oloktsidou, Vasileios Ourailoglou, Konstantinos Papapostolou, Georgia Tsaousi, Panagoula Daikou, Georgia Dedemadi, Ioannis Kalaitzopoulos, Christos Loumpias, Sotirios Bristogiannis, Nikolaos Dafnios, Georgios Gkiokas, Elissaios Kontis, Dimitra Kozompoli, Aspasia Papailia, Theodosios Theodosopoulos, Christol Bizios, Anastasia Koutsikou, Aleaxandra Moustaka, Ioannis Plaitakis, Apostolos Armaganidis, Theodora Christodoulopoulou, Mihail Lignos, Maria Theodorakopoulou, Andreas Asimakos, Eleni Ischaki, Angeliki Tsagkaraki, Spyros Zakynthinos, Eleni Antoniadou, Ioannis Koutelidakis, Dimitrios Lathyris, Irene Pozidou, Nikolaos Voloudakis, Maria Dalamagka, Gkonezou Elena, Christos Chronis, Dimitra Manolakaki, Dimitris Mosxogiannidis, Tatiana Slepova, Isaia-sissy Tsakiridou, Claire Lampiri, Anastasia Vachlioti, Christos Panagiotakis, Dimitrios Sfyras, Fotios Tsimpoukas, Athanasia Tsirogianni, Elena Axioti, Andreas Filippopoulos, Elli Kalliafa, George Kassavetis, Petros Katralis, Ioannis Komnos, Georgios Pilichos, Ifigenia Ravani, Antonis Totis, Eymorfia Apagaki, Andromachi Efthymiadi, Nikolaos Kampagiannis, Theoniki Paraforou, Agoritsa Tsioka, Georgios Georgiou, Aristeidis Vakalos, Aggeliki Bairaktari, Efthimios Charitos, George Markou, Panagiota Niforopoulou, Nikolaos Papakonstantinou, Evdoxia Tsigou, Archontoula Xifara, Menelaos Zoulamoglou, Panagiota Gkioni, Stylianos Karatzas, Aikaterini Kyparissi, Efstratios Mainas, Ioannis Papapanagiotou, Theonymfi Papavasilopoulou, George Fragandreas, Eleni Georgopoulou, Eleni Katsika, Kyriakos Psarras, Eirini Synekidou, Maria Verroiotou, Evangelia Vetsiou, Donika Zaimi, Athina Anagnou, Konstantinos Apostolou, Theodora Melissopoulou, Theophilos Rozenberg, Christos Tsigris, Georgios Boutsikos, Vasileios Kalles, Nikolaos Kotsalas, Christina Lavdaiou, Fotini Paikou, Georgia-Laura Panagou, Anna Spring, Ioannis Botis, Maria Drimala, Georgios Georgakakis, Ellada Kiourtzieva, Panagiota Ntouma, Apostolos Prionas, Kyriakos Xouplidis, 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Weatherill, Zoe Whitman, Elinor Wighton, Chamika Abayasinghe, Alexander Chan, Sharif Darwish, James Gill, Emma Glasgow, Daniel Hadfield, Clair Harris, Phil Hopkins, Arun Kochhar, Gudrun Kunst, Clare Mellis, Andrew Pool, Paul Riozzi, Andrew Selman, Emma-Jane Smith, Liana Vele, Yuksel Gercek, Kramer Guy, Douglas Holden, Nicholas Watson, Karen Whysall, Prematie Andreou, Dawn Hales, Jonathan Thompson, Sarah Bowrey, Shara McDonald, Jemma Gilmore, Vicky Hills, Chan Kelly, Sinead Kelly, Geraint Lloyd, Tom Abbott, Lewis Gall, Hew Torrance, Mark Vivian, Emer Berntsen, Tracey Nolan, Angus Turner, Akbar Vohra, Andrew Brown, Richard Clark, Elaine Coughlan, Conway Daniel, Chinmay Patvardhan, Rachel Pearson, Sheba Predeep, Hesham Saad, Mohanakrishnan Shanmugam, Simon Varley, Katharine Wylie, Lucy Cooper, Arystarch Makowski, Beata Misztal, Eliza Moldovan, Claire Pegg, Andrew Donovan, Jayne Foot, Simon Large, Andrew Claxton, Bhagyashree Netke, Richard Armstrong, Claire Calderwood, Andy Kwok, Otto Mohr, Peter Oyeniyi, Lisa Patnaik, Benjamin Post, Sarah Ali, Homa Arshad, Gerard Baker, Laura Brenner, Maximilian Brincat, Annemarie Brunswicker, Hannah Cox, Octavian Ionut Cozar, Edward Cheong, Alexander Durst, Lior Fengas, Jim Flatt, Georgina Glister, Vishal Narwani, Evangelos Photi, Adeline Rankin, Melissa Rosbergen, Mark Tan, Ceri Beaton, Rachel Horn, Jane Hunt, Guy Rousseau, Lucia Stancombe, Mohammed Absar, Joanne Allsop, Zoe Drinkwater, Tracey Hodgkiss, Kirsty Smith, Jamie Brown, Farhad Alexander-Sefre, Lorraine Campey, Lucy Dudgeon, Kathryn Hall, Rachael Hitchcock, Lynne James, Kate Smith, Ulrika Winstone, Norfaizan Ahmad, Kris Bauchmuller, Jonathan Harrison, Holly Jeffery, Duncan Miller, Angela Pinder, Sailaja Pothuneedi, Jonathan Rosser, Sumayer Sanghera, Diane Swift, Rachel Walker, Delia Bester, Sarah Cavanagh, Heather Cripps, Harvey Daniel, Julie Lynch, Alison Paton, Shirley Pyke, John Scholefield, Helen Whitworth, Fiona Bottrill, Ganesh Ramalingam, Stephen Webb, Nik 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Thomas, Joanne Thunder, Andrew Torrance, Ravinder Vohra, null Arlo whitehouse, Tony Wong, Mark Blunt, Kate Wong, Julian Giles, Isabelle Reed, Debbie Weller, Gillian Bell, Julie Birch, Rose Damant, Jane Maiden, Clare Mewies, Claire Prince, Jane Radford, Tim Reynolds, Birender Balain, Robin Banerjee, Andrew Barnett, Ben Burston, Kirsty Davies, Jayne Edwards, Chris Evans, David Ford, Pete Gallacher, Simon Hill, David Jaffray, Sudheer Karlakki, Cormac Kelly, Julia Kennedy, Nigel Kiely, Simon Lewthwaite, Chris Marquis, Matthew Ockendon, Stephen Phillips, Simon Pickard, James Richardson, Richard Roach, Tony Smith, Richard Spencer-Jones, Niall Steele, Julie Steen, Marck Van Liefland, Steve White, Matthew Faulds, Meredyth Harris, Carrie Kelly, Scott Nicol, Sally Anne Pearson, Srikanth Chukkambotla, Alyson Andrew, Elizabeth Attrill, Graham Campbell, Amanda Datson, Anna Fouracres, Juan Graterol, Lynne Graves, Bosun Hong, Alexander Ishimaru, Arvind Karthikeyan, Helen King, Tom Lawson, Gregory 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Ian Wrench, Lisa Zeidan, Diane Ardern, Benjamin Harris, Johanna Hellstrom, Jane Martin, Richard Thomas, Nimu Varsani, Caroline Wrey Brown, Philip Docherty, Michael Gillies, Euan McGregor, Helen Usher, Jayne Craig, Andrew Smith, Tahania Ahmad, Phoebe Bodger, Thais Creary, Alexander Fowler, Russ Hewson, Eke Ijuo, Timothy Jones, Ilya Kantsedikas, Sumitra Lahiri, Aaron Lawson McLean, Edyta Niebrzegowska, Mandeep Phull, Difei Wang, Nadine Wickboldt, Jacqueline Baldwin, Donna Doyle, Sean Mcmullan, Michelle Oladapo, Thomas Owen, Alexandra Williams, Hull Daniel, Peter Gregory, Tauqeer Husain, Justin Kirk-Bayley, Edward Mathers, Laura Montague, Mark Harper, Stuart White, James Jack, Carrie Ridley, Joanne Avis, Tim Cook, Lola Dali-Kemmery, Ian Kerslake, Victoria Lambourne, Annabel Pearson, Christine Boyd, Mark Callaghan, Cathy Lawson, Roopa McCrossan, Vanessa Nesbitt, Laura O'connor, Julia Scott, Rhona Sinclair, Nahla Farid, Ciro Morgese, Kailash Bhatia, Swati Karmarkar, Jamil Ahmed, Graham Branagan, Monica Hutton, Andrew Swain, Jamie Brookes, Jonathan Cornell, Rachael Dolan, Jonathan Hulme, Amanda Jansen van Vuuren, Tom Jowitt, Gunasheela Kalashetty, Fran Lloyd, Kiran Patel, Nicholas Sherwood, Lynne Brown, Ben Chandler, Kerry Deighton, Temlett Emma, Kirsty Haunch, Michelle Cheeseman, Kathy Dent, Sanjeev Garg, Carol Gray, Marion Hood, Dawn Jones, Joanne Juj, Roshan Rao, Tara Walker, Mashel Al Anizi, Clarissa Cheah, Yushio Cheing, Francisco Coutinho, Prisca Gondo, Bernard Hadebe, Mazvangu Onie Hove, null Ahamed khader, Bobby Krishnachetty, Karen Rhodes, Jagdish Sokhi, Katie-Anne Baker, Wendy Bertram, Alex Looseley, Ronelle Mouton, George Hanna, Glenn Arnold, Shobhit Arya, Danai Balfoussia, Linden Baxter, James Harris, Craig Jones, Alison Knaggs, Sheraz Markar, Anisha Perera, Alasdair Scott, Asako Shida, Ravneet Sirha, Sally Wright, Victoria Frost, Catherine Gray, Emma Andrews, Lindsay Arrandale, Stephen Barrett, Elna Cifra, Mariese Cooper, Dragos Dragnea, Cifra Elna, Jennifer Maclean, Sonja Meier, Donald Milliken, Christopher Munns, Nadir Ratanshi, Suneil Ramessur, Abegail Salvana, Anthony Watson, Hani Ali, Gill Campbell, Rebecca Critchley, Simon Endersby, Catherine Hicks, Alison Liddle, Marc Pass, Charlotte Ritchie, Charlotte Thomas, Lingxi Too, Sarah Welsh, Talvinder Gill, Joanne Johnson, Joanne Reed, Edward Davis, Sam Papadopoullos, Clare Attwood, Andrew Biffen, Kerenza Boulton, Sophie Gray, David Hay, Sarah Mills, Jane Montgomery, Rory Riddell, James Simpson, Neeraj Bhardwaj, Elaine Paul, Nosakhare Uwubamwen, Maini Alexander, James Arrich, Swarna Arumugam, Douglas Blackwood, Victoria Boggiano, Robyn Brown, Yik Lam Chan, Devnandan Chatterjee, Ashok Chhabra, Rachel Christian, Hannah Costelloe, Madeline Coxwell Matthewman, Emma Dalton, Julia Darko, Maria Davari, Tejal Dave, Matthew Deacon, Shantal Deepak, Holly Edmond, Jessica Ellis, Ahmed El-Sayed, Philip Eneje, Rose English, Renee Ewe, William Foers, John Franklin, Laura Gallego, Emily Garrett, 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Queen Mary University of London (QMUL), Royal Free Hospital [London, UK], NHS Foundation Trust [London], The Royal Marsden, University of Cape Town, Linköping university hospital, University of Edinburgh, Abbott, T E F, Ahmad, T, Phull, M K, Fowler, A J, Hewson, R, Biccard, B M, Chew, M S, Gillies, M, Pearse RM, Beattie S, Clavien PA, Demartines N, Fleisher LA, Grocott M, Haddow J, Hoeft A, Holt P, Moreno R, Pritchard N, Rhodes A, Wijeysundera D, Wilson M, Ahmed T, Everingham K, Hewson R, Januszewska M, Phull MK, Halliwell R, Shulman M, Myles P, Schmid W, Hiesmayr M, Wouters P, de Hert S, Lobo S, Fang X, Rasmussen L, Futier E, Biais M, Venara A, Slim K, Sander M, Koulenti D, Arvaniti K, Chan M, Kulkarni A, Chandra S, Tantri A, Geddoa E, Abbas M, Della Rocca G, Sivasakthi D, Mansor M, Luna P, Bouwman A, Buhre W, Beavis V, Campbell D, Short T, Osinaike T, Matos R, Grigoras I, Kirov M, Protsenko D, Biccard B, Aldecoa C, Chew M, Hofer C, Hubner M, Ditai J, Szakmany T, Fleisher L, Ferguson M, MacMahon M, Cherian R, Currow H, Kanathiban K, Gillespie D, Pathmanathan E, Phillips K, Reynolds J, Rowley J, Douglas J, Kerridge R, Garg S, Bennett M, Jain M, Alcock D, Terblanche N, Cotter R, Leslie K, Stewart M, Zingerle N, Clyde A, Hambidge O, Rehak A, Cotterell S, Huynh WBQ, McCulloch T, Ben-Menachem E, Egan T, Cope J, Fellinger P, Haisjackl M, Haselberger S, Holaubek C, Lichtenegger P, Scherz F, Hoffer F, Cakova V, Eichwalder A, Fischbach N, Klug R, Schneider E, Vesely M, Wickenhauser R, Grubmueller KG, Leitgeb M, Lang F, Toro N, Bauer M, Laengle F, Haberl C, Mayrhofer T, Trybus C, Buerkle C, Forstner K, Germann R, Rinoesl H, Schindler E, Trampitsch E, Bogner G, Dankl D, Duenser M, Fritsch G, Gradwohl-Matis I, Hartmann A, Hoelzenbein T, Jaeger T, Landauer F, Lindl G, Lux M, Steindl J, Stundner O, Szabo C, Bidgoli J, Verdoodt H, Forget P, Kahn D, Lois F, Momeni M, Prégardien C, Pospiech A, Steyaert A, Veevaete L, De Kegel D, De Jongh K, Foubert L, Smitz C, Vercauteren M, Poelaert J, Van Mossevelde V, Abeloos J, Bouchez S, Coppens M, De Baerdemaeker L, Deblaere I, De Bruyne A, Fonck K, Heyse B, Jacobs T, Lapage K, Moerman A, Neckebroek M, Parashchanka A, Roels N, Van Den Eynde N, Vandenheuvel M, Limmen J, Vanluchene A, Vanpeteghem C, Wyffels P, Huygens C, Vandenbempt P, Van de Velde M, Dylst D, Janssen B, Schreurs E, Aleixo FB, Candido K, Batista HD, Guimarães M, Guizeline J, Hoffmann J, Lobo FRM, Nascimento V, Nishiyama K, Pazetto L, Souza D, Rodrigues RS, Vilela Dos Santos AM, Jardim J, Sá Malbouisson LM, Silva J, Nascimento Junior PD, Baio TH, Pereira de Castro GI, Watanabe Oliveira HR, Amendola CP, Cardoso G, Ortega D, Brotto AF, De Oliveira MC, Réa-Neto Á, Dias F, Travi ME, Zerman L, Azambuja P, Knibel MF, Martins A, Almeida W, Neto CN, Tardelli MA, Caser E, Machado M, Aguzzoli C, Baldisserotto S, Tabajara FB, Bettega F, Rodrigues Júnior HC, de Gasperi J, Faina L, Nolasco MF, Ferreira da Costa Fischer B, Fosch de Campos Ferreira M, Hartmann C, Kliemann M, Hubert Ribeiro GL, Fraga JM, Netto TM, Pozza LV, Wendling PR, Azevedo C, Garcia J, Lopes M, Maia B, Maselli P, Melo R, Mendes W, Neves M, Ney J, Piras C, Applewhaite C, Carr A, Chow L, Duttchen K, Foglia J, Greene M, Hinther A, Houston K, McCormick TJ, Mikhayel J, Montasser S, Ragan A, Suen A, Woolsey A, Yu HC, Funk D, Kowalski S, Legaspi R, McDonald H, Siddiqui F, Pridham J, Rowe B, Sampson S, Thiessen B, Zbitnew G, Bernard A, George R, Jones P, Moor R, Siddiqui N, Wolfer A, Tran D, Winch D, Dobson G, McCormick T, Montasser O, Hall R, Baghirzada L, Curley G, Dai SY, Hare G, Lee E, Shastri U, Tsui A, Yagnik A, Alvares D, Choi S, Dwyer H, Flores K, McCartney C, Somascanthan P, Carroll J, Pazmino-Canizares J, Wolfer A, Ami N, Chan V, Perlas A, Argue R, Huang Y, Lavis K, Mayson K, Cao Y, Gao H, Hu T, Lv J, Yang J, Yang Y, Zhong Y, Zhou J, Zou X, He M, Li X, Luo D, Wang H, Yu T, Chen L, Wang L, Cai Y, Cao Z, Li Y, Lian J, Sun H, Wang S, Wang Z, Wang K, Zhu Y, Du X, Fan H, Fu Y, Huang L, Huang Y, Hwan H, Luo H, Qu PS, Tao F, Wang Z, Wang G, Wang S, Zhang Y, Zhang X, Chen C, Wang W, Liu Z, Fan L, Tang J, Chen Y, Chen Y, Han Y, Huang C, Liang G, Shen J, Wang J, Yang Q, Zhen J, Zhou H, Chen J, Chen Z, Li X, Meng B, Ye H, Zhang X, Bi Y, Cao J, Guo F, Lin H, Liu Y, Lv M, Shi P, Song X, Sun C, Sun Y, Wang Y, Wang S, Zhang M, Chen R, Hou J, Leng Y, Meng QT, Qian L, Shen ZY, Xia ZY, Xue R, Zhang Y, Zhao B, Zhou XJ, Chen Q, Guo H, Guo Y, Qi Y, Wang Z, Wei J, Zhang W, Zheng L, Bao Q, Chen Y, Chen Y, Fei Y, Hu N, Hu X, Lei M, Li X, Lv X, Miao F, Ouyang L, Qian L, Shen C, Sun Y, Wang Y, Wang D, Wu C, Xu L, Yuan J, Zhang L, Zhang H, Zhang Y, Zhao J, Zhao C, Zhao L, Zheng T, Zhou D, Zhou H, Zhou C, Lu K, Zhao T, He C, Chen H, Chen S, Cheng B, He J, Jin L, Li C, Li H, Pan Y, Shi Y, Wen XH, Wu S, Xie G, Zhang K, Zhao B, Lu X, Chen F, Liang Q, Lin X, Ling Y, Liu G, Tao J, Yang L, Zhou J, Chen F, Cheng Z, Dai H, Feng Y, Hou B, Gong H, Hu CH, Huang H, Huang J, Jiang Z, Li M, Lin J, Liu M, Liu W, Liu Z, Liu Z, Luo F, Ma L, Min J, Shi X, Song Z, Wan X, Xiong Y, Xu L, Yang S, Zhang Q, Zhang H, Zhang H, Zhang X, Zhao L, Zhao W, Zhao W, Zhu X, Bai Y, Chen L, Chen S, Dai Q, Geng W, Han K, He X, Huang L, Ji B, Jia D, Jin S, Li Q, Liang D, Luo S, Lwang L, Mo Y, Pan Y, Qi X, Qian M, Qin J, Ren Y, Shi Y, Wang J, Wang J, Wang L, Xie J, Yan Y, Yao Y, Zhang M, Zhao J, Zhuang X, Ai Y, Du F, He L, Huang L, Li Z, Li H, Li Y, Li L, Meng S, Yuan Y, Zhang E, Zhang J, Zhao S, Ji Z, Pei L, Wang L, Chen C, Dong B, Li J, Miao Z, Mu H, Qin C, Su L, Wen Z, Xie K, Yu Y, Yuan F, Hu X, Zhang Y, Xiao W, Zhu Z, Dai Q, Fu K, Hu R, Hu X, Huang S, Li Y, Liang Y, Yu S, Guo Z, Jing Y, Tang N, Wu J, Yuan D, Zhang R, Zhao X, Li Y, Bai HP, Liu CX, Liu FF, Ren W, Wang XL, Xu GJ, Hu N, Li B, Ou Y, Tang Y, Yao S, Zhang S, Kong CC, Liu B, Wang T, Xiao W, Lu B, Xia Y, Zhou J, Cai F, Chen P, Hu S, Wang H, Xu Q, Hu L, Jing L, Li B, Liu Q, Liu Y, Lu X, Peng ZD, Qiu X, Ren Q, Tong Y, Wang J, Wen Y, Wu Q, Xia J, Xie J, Xiong X, Xu S, Yang T, Ye H, Yin N, Yuan J, Zeng Q, Zhang B, Zheng K, Cang J, Chen S, Fan Y, Fu S, Ge X, Guo B, Huang W, Jiang L, Jiang X, Liu Y, Pan Y, Ren Y, Shan Q, Wang J, Wang F, Wu C, Zhang X, Christiansen IC, Granum SN, Rasmussen BS, Daugaard M, Gambhir R, Brandsborg B, Steingrímsdóttir GE, Jensen-Gadegaard P, Olsen KS, Siegel H, Eskildsen KZ, Gätke MR, Wibrandt I, Heintzelmann SB, Wiborg Lange KH, Lundsgaard RS, Amstrup-Hansen L, Hovendal C, Larsen M, Lenstrup M, Kobborg T, Larsen JR, Pedersen AB, Smith SH, Oestervig RM, Afshari A, Andersen C, Ekelund K, Secher EL, Beloeil H, Lasocki S, Ouattara A, Sineus M, Molliex S, Legouge ML, Wallet F, Tesniere A, Gaudin C, Lehur P, Forsans E, de Rudnicki S, Maudet VS, Mutter D, Sojod G, Ouaissi M, Regimbeau JM, Desbordes J, Comptaer N, Manser DE, Ethgen S, Lebuffe G, Auer P, Härtl C, Deja M, Legashov K, Sonnemann S, Wiegand-Loehnert C, Falk E, Habicher M, Angermair S, Laetsch B, Schmidt K, Von Heymann C, Ramminger A, Jelschen F, Pabel S, Weyland A, Czeslick E, Gille J, Malcharek M, Sablotzki A, Lueke K, Wetzel P, Weimann J, Lenhart FP, Reichle F, Schirmer F, Hüppe M, Klotz K, Nau C, Schön J, Mencke T, Wasmund C, Bankewitz C, Baumgarten G, Fleischer A, Guttenthaler V, Hack Y, Kirchgaessner K, Männer O, Schurig-Urbaniak M, Struck R, van Zyl R, Wittmann M, Goebel U, Harris S, Veit S, Andreadaki E, Souri F, Katsiadramis I, Skoufi A, Vasileiou M, Aimoniotou-Georgiou E, Katsourakis A, Veroniki F, Vlachogianni G, Petra K, Chlorou D, Oloktsidou E, Ourailoglou V, Papapostolou K, Tsaousi G, Daikou P, Dedemadi G, Kalaitzopoulos I, Loumpias C, Bristogiannis S, Dafnios N, Gkiokas G, Kontis E, Kozompoli D, Papailia A, Theodosopoulos T, Bizios C, Koutsikou A, Moustaka A, Plaitakis I, Armaganidis A, Christodoulopoulou T, Lignos M, Theodorakopoulou M, Asimakos A, Ischaki E, Tsagkaraki A, Zakynthinos S, Antoniadou E, Koutelidakis I, Lathyris D, Pozidou I, Voloudakis N, Dalamagka M, Elena G, Chronis C, Manolakaki D, Mosxogiannidis D, Slepova T, Tsakiridou IS, Lampiri C, Vachlioti A, Panagiotakis C, Sfyras D, Tsimpoukas F, Tsirogianni A, Axioti E, Filippopoulos A, Kalliafa E, Kassavetis G, Katralis P, Komnos I, Pilichos G, Ravani I, Totis A, Apagaki E, Efthymiadi A, Kampagiannis N, Paraforou T, Tsioka A, Georgiou G, Vakalos A, Bairaktari A, Charitos E, Markou G, Niforopoulou P, Papakonstantinou N, Tsigou E, Xifara A, Zoulamoglou M, Gkioni P, Karatzas S, Kyparissi A, Mainas E, Papapanagiotou I, Papavasilopoulou T, Fragandreas G, Georgopoulou E, Katsika E, Psarras K, Synekidou E, Verroiotou M, Vetsiou E, Zaimi D, Anagnou A, Apostolou K, Melissopoulou T, Rozenberg T, Tsigris C, Boutsikos G, Kalles V, Kotsalas N, Lavdaiou C, Paikou F, Panagou GL, Spring A, Botis I, Drimala M, Georgakakis G, Kiourtzieva E, Ntouma P, Prionas A, Xouplidis K, Dalampini E, Giannaki C, Iasonidou C, Ioannidis O, Lavrentieva A, Lavrentieva A, Papageorgiou G, Kokkinoy M, Stafylaraki M, Gaitanakis S, Karydakis P, Paltoglou J, Ponireas P, Chaloulis P, Provatidis A, Sousana A, Gardikou VV, Konstantivelli M, Lataniotou O, Lisari E, Margaroni M, Stamatiou K, Nikolaidis E, Pnevmatikos I, Sertaridou E, Andreou A, Arkalaki E, Athanasakis E, Chaniotaki F, Chatzimichali CA, Christofaki M, Dermitzaki D, Fiorentza K, Frantzeskos G, Geromarkaki E, Kafkalaki K, Kalogridaki M, Karydi K, Kokkini S, Kougentakis G, Lefaki T, Lilitsis E, Makatounaki A, Malliotakis P, Michelakis D, Neonaki M, Nyktari V, Palikyra I, Papadakis E, Papaioannou A, Sfakianakis K, Sgouraki M, Souvatzis X, Spartinou A, Stefanidou N, Syrogianni P, Tsagkaraki G, Arnaoutoglou E, Arnaoutoglou C, Bali C, Bouris V, Doumos R, Gkini KP, Kapaktsi C, Koulouras V, Lena A, Lepida D, Michos E, Papadopoulos D, Paschopoulos M, Rompou VA, Siouti I, Tsampalas S, Ververidou O, Zilis G, Charlalampidoy A, Christodoulidis G, Flossos A, Stamoulis K, Chan M, Tsang MSC, Tsang MS, Lai ML, Yip CP, Heymans Chan HM, Law B, Li WS, Chu HM, Koo EGY, Lam CCJ, Cheng KH, Lam T, Chu S, Lam WY, Wong KWK, Kwok D, Hung CYJ, Chan WKJ, Wong WL, Chung CKE, Ma SK, Kaushik S, Shah B, Shah D, Shah S, Ar P, Muthuchellappan R, Agarwal V, Divatia J, Mishra S, Nimje G, Pande S, Savarkar S, Shrivastava A, Thomas M, Yegnaram S, Hidayatullah R, Puar N, Niman S, Indra I, Hamzah Z, Yuliana A, Abidin UN, Dursin AN, Kurnia A, Susanti A, Handayani D, Alit MA, Arya A, Senapathi TGA, Utara UH, Wid WM, Wima S, Wir WM, Jehosua B, Kaunang J, Lantang EY, Najoan R, Waworuntu N, Awad H, Fuad A, Geddoa B, Khalaf AR, Al Hussaini S, Albaj S, Kenber M, Bettinelli A, Spadaro S, AlbertoVolta C, Giancarlo L, Sottosanti V, Copetti E, Spagnesi L, Toretti I, Alloj C, Cardellino S, Carmino L, Costanzo E, Fanfani LC, Novelli MT, Roasio A, Bellandi M, Beretta L, Bignami E, Bocchino S, Cabrini L, Corti D, Landoni G, Meroni R, Moizo E, Monti G, Pintaudi M, Plumari VP, Taddeo D, Testa V, Winterton D, Zangrillo A, Cloro LM, Colangelo C, Colangelo A, Rotunno G, Paludi MA, Maria CP, Pata A, Parrini V, Gatta A, Nastasi M, Tinti C, Baroselli A, Arrigo M, Benevento A, Bottini C, Cannavo' M, Gastaldi C, Marchesi A, Pascazio A, Pata F, Pozzi E, Premoli A, Tessera G, Boschi L, D'Andrea R, Ghignone F, Poggioli G, Sibilio A, Taffurelli M, Ugolini G, Ab Majid MA, Ab Rahman R, Joseph J, Pathan F, Sybil Shah MH, Yap HL, Cheah S, Chin II, Looi JK, Tan SC, Visvalingam S, Kwok FY, Lee CK, Tan TS, Wong SM, Abdullah NH, Liew CF, Luxuman L, Mohd Zin NH, Norddin MF, Raja Alias RL, Wong JY, Yong J, Bin Mustapha MT, Chan WK, Dzulkipli N, Kuan PX, Lee YC, Alias A, Guok EC, Jee CC, Ramon BR, Wong CW, Abd Ghafar FNI, Aziz FZ, Hussain N, Lee HS, Sukawi I, Woon YL, Abd Hadi HZ, Ahmad Azam UA, Alias AH, Kesut SA, Lee JM, Ooi DV, Sulaiman HA, Lih TAT, Veerakumaran J, Rojas E, Resendiz GEA, Zapata DDM, López JCJA, Flores AAA, Amador JCB, Avila EJD, Aquino LPG, Rodriguez RL, Landa MT, Urias E, Hollmann M, Hulst A, Benedikt Preckel OK, Gemert AK, Buise M, Tolenaar N, Weber E, de Fretes J, Houweling P, Ormskerk P, Van Bommel J, Lance M, Smit-Fun V, van Zundert T, Baas P, de Boer HD, Sprakel J, Elferink-Vonk R, Noordzij P, van Zeggeren L, Brand B, Spanjersberg R, Bokkel-Andela JT, Numan S, van Klei W, van Zaane B, Boer C, van Duivenvoorde Y, Hering JP, van Rossum S, Zonneveldt H, Campbell D, Hoare S, Santa S, Ali M, Allen SJ, Beavis V, Bell R, Choi HD, Drake M, Farrell H, Hayes K, Higgie K, Holmes K, Jenkins N, Kim CJ, Kim S, Law KC, McAllister D, Park K, Pedersen K, Pfeifer L, Pozaroszczyk A, Salmond T, Steynor M, Tan M, Waymouth E, Ab Rahman AS, Armstrong J, Dudson R, Jenkins N, Nilakant J, Richard S, Virdi P, Dixon L, Donohue R, Farrow M, Kennedy R, Marissa H, McKellow M, Nicola D, Pascoe R, Roberts SJ, Rowell G, Sumner M, Templer P, Chandrasekharan S, Fulton G, Jammer I, More R, Wilson L, Chang YH, Foley J, Fowler C, Panckhurst J, Sara R, Stapelberg F, Cherrett V, Ganter DL, McCann L, Gilmour F, Lumsden R, Moores M, Olliff S, Sardareva E, Tai J, Wikner M, Wong C, Chaddock M, Czepanski C, McKendry P, Polakovic D, Polakovich D, Robert A, Belda MT, Norton T, Alherz F, Barneto L, Ramirez A, Sayeed A, Smith N, Bennett C, McQuoid S, Jansen TL, Nico Z, Scott J, Freschini D, Freschini A, Hopkins B, Manson L, Stoltz D, Bates A, Davis S, Freeman V, McGaughran L, Williams M, Sharma SB, Burrows T, Byrne K, English D, Johnson R, Manikkam B, Naidoo S, Rumball M, Whittle N, Franks R, Gibson-Lapsley H, Salter R, Walsh D, Cooper R, Perry K, Obobolo A, Sule UM, Ahmad A, Atiku M, Mohammed AD, Sarki AM, Adekola O, Akanmu O, Durodola A, Olukoju O, Raji V, Olajumoke T, Oyebamiji E, Adenekan A, Adetoye A, Faponle F, Olateju S, Owojuyigbe A, Talabi A, Adenike O, Adewale B, Collins N, Ezekiel E, Fatungase OM, Grace A, Sola S, Stella O, Ademola A, Adeolu AA, Adigun T, Akinwale M, Fasina O, Gbolahan O, Idowu O, Olonisakin RP, Osinaike BB, Asudo F, Mshelia D, Abdur-Rahman L, Agodirin O, Bello J, Bolaji B, Oyedepo OO, Ezike H, Iloabachie I, Okonkwo I, Onuora E, Onyeka T, Ugwu I, Umeh F, Alagbe-Briggs O, Dodiyi-Manuel A, Echem R, Obasuyi B, Onajin-Obembe B, Bandeira ME, Martins A, Tomé M, Costa ACMM, Krystopchuk A, Branco T, Esteves S, Melo MA, Monte J, Rua F, Martins I, Pinho-Oliveira VM, Rodrigues CM, Cabral R, Marques S, Rêgo S, Jesus JST, Marques MC, Romao C, Dias S, Santos AM, Alves MJ, Salta C, Cruz S, Duarte C, Paiva AAF, Cabral TDN, Faria E Maia D, Correia da Silva RFM, Langner A, Resendes HO, Soares MDC, Abrunhosa A, Faria F, Miranda L, Pereira H, Serra S, Ionescu D, Margarit S, Mitre C, Vasian H, Manga G, Stefan A, Tomescu D, Filipescu D, Paunescu MA, Stefan M, Stoica R, Gavril L, Pătrășcanu E, Ristescu I, Rusu D, Diaconescu C, Iosep GF, Pulbere D, Ursu I, Balanescu A, Grintescu I, Mirea L, Rentea I, Vartic M, Lupu MN, Stanescu D, Streanga L, Antal O, Hagau N, Patras D, Petrisor C, Tosa F, Tranca S, Copotoiu SM, Ungureanu LL, Harsan CR, Papurica M, Cernea DD, Dragoescu NA, CarmenVaida LA, Ciobotaru OR, Aignatoaie M, Carp CP, Cobzaru I, Mardare O, Purcarin B, Tutunaru V, Ionita V, Arustei M, Codita A, Busuioc M, Chilinciuc I, Ciobanu C, Belciu I, Tincu E, Blaj M, Grosu RM, Sandu G, Bruma D, Corneci D, Dutu M, Krepil A, Copaciu E, Dumitrascu CO, Jemna R, Mihaescu F, Petre R, Tudor C, Ursache E, Kulikov A, Lubnin A, Grigoryev E, Pugachev S, Tolmasov A, Hussain A, Ilyina Y, Roshchina A, Iurin A, Chazova E, Dunay A, Karelov A, Khvedelidze I, Voldaeva O, Belskiy V, Dzhamullaev P, Grishkowez E, Kretov V, Levin V, Molkov A, Puzanov S, Samoilenko A, Tchekulaev A, Tulupova V, Utkin I, Allorto NL, Bishop DG, Builu PM, Cairns C, Dasrath A, de Wet J, Hoedt MD, Grey B, Hayes MP, Küsel BS, Shangase N, Wise R, Cacala S, Farina Z, Govindasamy V, Kruse CH, Lee C, Marais L, Naidoo TD, Rajah C, Rodseth RN, Ryan L, von Rhaden R, Adam S, Alphonsus C, Ameer Y, Anderson F, Basanth S, Bechan S, Bhula C, Biccard BM, Biyase T, Buccimazza I, Cardosa J, Chen J, Daya B, Drummond L, Elabib A, Abdel Goad EH, Goga IE, Goga R, Harrichandparsad R, Hodgson RE, Jordaan J, Kalafatis N, Kampik C, Landers AT, Loots E, Madansein R, Madaree A, Madiba TE, Manzini VT, Mbuyisa M, Moodley R, Msomi M, Mukama I, Naidoo D, Naidoo R, Naidu TK, Ntloko S, Padayachee E, Padayachee L, Phaff M, Pillay B, Pillay D, Pillay L, Ramnarain A, Ramphal SR, Ryan P, Saloojee A, Sebitloane M, Sigcu N, Taylor JL, Torborg A, Visser L, Anderson P, Conradie A, de Swardt M, de Villiers M, Eikman J, Liebenberg R, Mouton J, Paton A, van der Merwe L, Wilscott-Davids C, Barrett WJ, Bester M, de Beer J, Geldenhuys J, Gouws H, Potgieter JH, Strydom M, WilberforceTurton E, Chetty RR, Chirkut S, Cronje L, de Vasconcellos K, Dube NZ, Gama NS, Green GM, Green-Thompson R, Kinoo SM, Kistnasami P, Maharaj K, Moodley MS, Mothae SJ, Naidoo R, Aslam F Noorbhai M, Rughubar V, Reddy J, Singh A, Skinner DL, Smith MJ, Singh B, Misra R, Naidoo M, Ramdharee P, Selibea Y, Sewpersad S, Sham S, Wessels JD, Africander C, Bejia T, Blakemore SP, Botes M, Bunwarie B, Hernandez CB, Jeeraz MA, Legutko DA, Lopez AG, De Meyer JN, Muzenda T, Naidoo N, Patel M, Pentela R, Junge M, Mansoor N, Rademan L, Scislowski P, Seedat I, van den Berg B, van der Merwe D, van Wyk S, Govender K, Naicker D, Ramjee R, Saley M, Kuhn WP, Matos-Puig R, Alberto Lisi ZM, Perez G, Beltran AV, Lozano A, Navarro CD, Duca A, Ernesto EPM, Ferrando C, Fuentes I, García-Pérez ML, Gracia E, Palomares AI, Katime A, Miñana A, Incertis RR, Romero E, Romero Garcia CS, Rubio C, Artiles TS, Soro M, Valls P, Laguarda GA, Benavent P, Cuenca VC, Cueva A, Lafuente M, Parra AM, Rodrigo AR, Sanchez-Morcillo S, Tormo S, Redondo FJ, De Andrés Ibanez JA, Diago LG, José Hernández Cádiz M, Manuel GG, Peris R, Saiz C, Vivo JT, Soto MTT, Brunete T, Cancho D, Delgado García DR, Zamudio D, Del Valle SG, Serrano ML, Alonso E, Anillo V, Maseda E, Salgado P, Suarez L, Suarez-de-la-Rica A, Villagrán MJ, Alonso JI, Cabezuelo E, Garcia-Saiz I, Lopez Del Moral O, Martín S, Gonzalez AP, Doncel MST, Vera MA, José Ávila Sánchez F, Castaño B, Moreira BC, Risco SF, Martín DP, Martín FP, Poza P, Ruiz A, Serna Martínez WF, Vicente BV, Dominguez SV, Fernández S, Munoz-López A, Bernat MJ, Mas A, Planas K, Jawad M, Saeed Y, Hedin A, Levander H, Holmström S, Lönn D, Zoerner F, Åkring I, Widmark C, Zettergren J, Liljequist VA, Nystrom L, Odeberg-Wernerman S, Oldner A, Fagerlund MJ, Reje P, Lyckner S, Sperber J, Adolfsson A, Klarin B, Ögren K, Barras JP, Bührer T, Despotidis V, Helmy N, Holliger S, Raptis DA, Schmid R, Meyer A, Jaquet Y, Kessler U, Muradbegovic M, Nahum SR, Rotunno T, Schiltz B, Voruz F, Worreth M, Christoforidis D, Popeskou SG, Furrer M, Prevost GA, Stocker A, Lang K, Breitenstein S, Ganter MT, Geisen M, Soll C, Korkmaz M, Lubach I, Schmitz M, Meyer Zu Schwabedissen M, Moritz MZS, Zingg U, Hillermann T, Wildi S, Pinto BB, Walder B, Mariotti G, Slankamenac K, Namuyuga M, Kyomugisha E, Kituuka O, Shikanda AW, Kakembo N, Tom CO, Antonina W, Bua E, Ssettabi EM, Epodoi J, Kabagenyi F, Kirya F, Dempsey G, Seasman C, Nawaz Khan RB, Kurasz C, Macgregor M, Shawki B, Francis D, Hariharan V, Chau S, Ellis K, Butt G, Chicken DW, Christmas N, Allen S, Daniel GD, Dempster A, Kemp J, Matthews L, Mcglone P, Tambellini J, Trodd D, Freitas K, Garg A, Gupta JK, Karpate S, Kulkarni A, O'Hara C, Troko J, Angus K, Bradley J, Brennan E, Brooks C, Brown J, Brown G, Finch A, Gratrix K, Hesketh S, Hill G, Jeffs C, Morgan M, Pemberton C, Slawson N, Spickett H, Swarbrick G, Thomas M, Van Duyvenvoorde G, Brennan A, Briscoe R, Cooper S, Lawton T, Northey M, Senaratne R, Stanworth H, Burrows L, Cain H, Craven R, Davies K, Jonas A, Pachucki M, Walkden G, Davies H, Gudaca M, Hobrok M, Arawwawala D, Fergey L, Gardiner M, Gunn J, Johnson L, Lofting A, Lyle A, Neela FM, Smolen S, Topliffe J, Williams S, Bland M, Balaji P, Kaura V, Lanka P, Smith N, Ahmed A, Myatt J, Shenoy R, Soon WC, Tan J, Karadia S, Self J, Durant E, Tripathi S, Bullock C, Campbell D, Ghosh A, Hughes T, Zsisku L, Bengeri S, Cowton A, Khalid MS, Limb J, McAdam C, Porritt M, Rafi MA, Shekar P, Adams D, Harden C, Hollands H, King A, March L, Minto G, Patrick A, Squire R, Waugh D, Kumara P, Simeson K, Yarwood J, Browning J, Hatton J, Julian H, Mitra A, Newton M, Pernu PK, Wilson A, Commey T, Foot H, Glover L, Gupta A, Lancaster N, Levin J, Mackenzie F, Mestanza C, Nofal E, Pout L, Varden R, Wild J, Jones S, Moreton S, Pulletz M, Davies C, Martin M, Thomas S, Burns K, McArthur C, Patel P, Lau G, Rich N, Davis F, Lyons R, Port B, Prout R, Smith C, Adelaja Y, Bennett V, Bidd H, Dumitrescu A, Murphy JF, Keen A, Mguni N, Ong C, Adams G, Boshier P, Brown R, Butryn I, Chatterjee J, Freethy A, Lockwood G, Tsakok M, Tsiligiannis S, Peat W, Stephenson L, Bradburn M, Pick S, Cunha P, Olagbaiye O, Tayeh S, Packianathaswamy B, Abernethy C, Balasubramaniam M, Bennett R, Bolton D, Martinson V, Naylor C, Bell S, Heather B, Kushakovsky V, Alcock L, Alexander H, Anderson C, Baker P, Brookes M, Cawthorn L, Cirstea E, Clarkson R, Colling K, Coulter I, Das S, Haigh K, Hamdan A, Hugill K, Kottam L, Lisseter E, Mawdsley M, McGivern J, Padala K, Phelps V, Ramesh Kumar V, Stewart K, Towse K, Tregonning J, Vahedi A, Walker A, Baines D, Bilolikar A, Chande S, Copley E, Dunk N, Kulkarni R, Kumar P, Metodiev Y, Ncomanzi D, Raithatha B, Raymode P, Szafranski J, Twohey L, Watt P, Weatherall L, Weatherill J, Whitman Z, Wighton E, Abayasinghe C, Chan A, Darwish S, Gill J, Glasgow E, Hadfield D, Harris C, Hopkins P, Kochhar A, Kunst G, Mellis C, Pool A, Riozzi P, Selman A, Smith EJ, Vele L, Gercek Y, Guy K, Holden D, Watson N, Whysall K, Andreou P, Hales D, Thompson J, Bowrey S, McDonald S, Gilmore J, Hills V, Kelly C, Kelly S, Lloyd G, Abbott T, Gall L, Torrance H, Vivian M, Berntsen E, Nolan T, Turner A, Vohra A, Brown A, Clark R, Coughlan E, Daniel C, Patvardhan C, Pearson R, Predeep S, Saad H, Shanmugam M, Varley S, Wylie K, Cooper L, Makowski A, Misztal B, Moldovan E, Pegg C, Donovan A, Foot J, Large S, Claxton A, Netke B, Armstrong R, Calderwood C, Kwok A, Mohr O, Oyeniyi P, Patnaik L, Post B, Ali S, Arshad H, Baker G, Brenner L, Brincat M, Brunswicker A, Cox H, Cozar OI, Cheong E, Durst A, Fengas L, Flatt J, Glister G, Narwani V, Photi E, Rankin A, Rosbergen M, Tan M, Beaton C, Horn R, Hunt J, Rousseau G, Stancombe L, Absar M, Allsop J, Drinkwater Z, Hodgkiss T, Smith K, Brown J, Alexander-Sefre F, Campey L, Dudgeon L, Hall K, Hitchcock R, James L, Smith K, Winstone U, Ahmad N, Bauchmuller K, Harrison J, Jeffery H, Miller D, Pinder A, Pothuneedi S, Rosser J, Sanghera S, Swift D, Walker R, Bester D, Cavanagh S, Cripps H, Daniel H, Lynch J, Paton A, Pyke S, Scholefield J, Whitworth H, Bottrill F, Ramalingam G, Webb S, Akerman N, Antill P, Bourner L, Buckley S, Castle G, Charles R, Eggleston C, Foster R, Gill S, Lindley K, Lklouk M, Lowery T, Martin O, Milne D, O'Connor P, Ratcliffe A, Rose A, Smith A, Varma S, Ward J, Barcraft-Barnes H, Camsooksai J, Colvin C, Reschreiter H, Tbaily L, Venner N, Hamilton C, Kelly L, Toth-Tarsoly P, Dodsworth K, Foord D, Gordon P, Hawes E, Lamb N, Mouland J, Nightingale J, Rose S, Schrieber J, Al'Amri K, Aladin H, Arshad MA, Barraclough J, Bentley C, Bergin C, Carrera R, Clarkson A, Collins M, Cooper L, Denham S, Griffiths E, Ip P, Jeyanthan S, Joory K, Kaur S, Marriott P, Mitchell N, Nagaiah S, Nilsson A, Parekh N, Pope M, Seager J, Serag H, Tameem A, Thomas A, Thunder J, Torrance A, Vohra R, Arlo Whitehouse, Wong T, Blunt M, Wong K, Giles J, Reed I, Weller D, Bell G, Birch J, Damant R, Maiden J, Mewies C, Prince C, Radford J, Reynolds T, Balain B, Banerjee R, Barnett A, Burston B, Davies K, Edwards J, Evans C, Ford D, Gallacher P, Hill S, Jaffray D, Karlakki S, Kelly C, Kennedy J, Kiely N, Lewthwaite S, Marquis C, Ockendon M, Phillips S, Pickard S, Richardson J, Roach R, Smith T, Spencer-Jones R, Steele N, Steen J, Van Liefland M, White S, Faulds M, Harris M, Kelly C, Nicol S, Pearson SA, Chukkambotla S, Andrew A, Attrill E, Campbell G, Datson A, Fouracres A, Graterol J, Graves L, Hong B, Ishimaru A, Karthikeyan A, King H, Lawson T, Lee G, Lyons S, Hall AM, Mathoulin S, Mcintyre E, Mclaughlin D, Mulcahy K, Paddle J, Ratcliffe A, Robbins J, Sung W, Tayo A, Trembath L, Venugopal S, Walker R, Wigmore G, Boereboom C, Downes C, Humphries R, Melbourne S, Smith C, Tou S, Ullah S, Batchelor N, Boxall L, Broomby R, Deen T, Hellewell A, Helliwell L, Hutchings M, Hutchins D, Keenan S, Mackie D, Potter A, Smith F, Stone L, Thorpe K, Wassall R, Woodgate A, Baillie S, Campbell T, James S, King C, Marques de Araujo D, Martin D, Morkane C, Neely J, Rajendram R, Burton M, James K, Keevil E, Minik O, Morgan J, Musgrave A, Rajanna H, Roberts T, Adamson M, Jumbe S, Kendall J, Muthuswamy MB, Anderson C, Cruikshanks A, Wrench I, Zeidan L, Ardern D, Harris B, Hellstrom J, Martin J, Thomas R, Varsani N, Brown CW, Docherty P, Gillies M, McGregor E, Usher H, Craig J, Smith A, Ahmad T, Bodger P, Creary T, Fowler A, Hewson R, Ijuo E, Jones T, Kantsedikas I, Lahiri S, McLean AL, Niebrzegowska E, Phull M, Wang D, Wickboldt N, Baldwin J, Doyle D, Mcmullan S, Oladapo M, Owen T, Williams A, Daniel H, Gregory P, Husain T, Kirk-Bayley J, Mathers E, Montague L, Harper M, White S, Jack J, Ridley C, Avis J, Cook T, Dali-Kemmery L, Kerslake I, Lambourne V, Pearson A, Boyd C, Callaghan M, Lawson C, McCrossan R, Nesbitt V, O'connor L, Scott J, Sinclair R, Farid N, Morgese C, Bhatia K, Karmarkar S, Ahmed J, Branagan G, Hutton M, Swain A, Brookes J, Cornell J, Dolan R, Hulme J, Jansen van Vuuren A, Jowitt T, Kalashetty G, Lloyd F, Patel K, Sherwood N, Brown L, Chandler B, Deighton K, Emma T, Haunch K, Cheeseman M, Dent K, Garg S, Gray C, Hood M, Jones D, Juj J, Rao R, Walker T, Al Anizi M, Cheah C, Cheing Y, Coutinho F, Gondo P, Hadebe B, Hove MO, Ahamed Khader, Krishnachetty B, Rhodes K, Sokhi J, Baker KA, Bertram W, Looseley A, Mouton R, Hanna G, Arnold G, Arya S, Balfoussia D, Baxter L, Harris J, Jones C, Knaggs A, Markar S, Perera A, Scott A, Shida A, Sirha R, Wright S, Frost V, Gray C, Andrews E, Arrandale L, Barrett S, Cifra E, Cooper M, Dragnea D, Elna C, Maclean J, Meier S, Milliken D, Munns C, Ratanshi N, Ramessur S, Salvana A, Watson A, Ali H, Campbell G, Critchley R, Endersby S, Hicks C, Liddle A, Pass M, Ritchie C, Thomas C, Too L, Welsh S, Gill T, Johnson J, Reed J, Davis E, Papadopoullos S, Attwood C, Biffen A, Boulton K, Gray S, Hay D, Mills S, Montgomery J, Riddell R, Simpson J, Bhardwaj N, Paul E, Uwubamwen N, Alexander M, Arrich J, Arumugam S, Blackwood D, Boggiano V, Brown R, Chan YL, Chatterjee D, Chhabra A, Christian R, Costelloe H, Matthewman MC, Dalton E, Darko J, Davari M, Dave T, Deacon M, Deepak S, Edmond H, Ellis J, El-Sayed A, Eneje P, English R, Ewe R, Foers W, Franklin J, Gallego L, Garrett E, Goldberg O, Goss H, Greaves R, Harris R, Hennings C, Jones E, Kamali N, Kokkinos N, Lewis C, Lignos L, Malgapo EV, Malik R, Milne A, Mulligan JP, Nicklin P, Palipane N, Parsons T, Piper R, Prakash R, Ramesh B, Rasip S, Reading J, Rela M, Reyes A, Stephens R, Rooms M, Shah K, Simons H, Solanki S, Spowart E, Stevens A, Thomas C, Waggett H, Yassaee A, Kennedy A, Scott S, Somanath S, Berg A, Hernandez M, Nanda R, Tank G, Wilson N, Wilson D, Al-Soudaine Y, Baldwin M, Cornish J, Davies Z, Davies L, Edwards M, Frewer N, Gallard S, Glasbey J, Harries R, Hopkins L, Kim T, Koompirochana V, Lawson S, Lewis M, Makzal Z, Scourfield S, Ahmad Y, Bates S, Blackwell C, Bryant H, Collins H, Coulter S, Cruickshank R, Daniel S, Daubeny T, Edwards M, Golder K, Hawkins L, Helen B, Hinxman H, Levett D, Salmon K, Seaward L, Skinner B, Tyrell B, Wadams B, Walsgrove J, Dickson J, Constantin K, Karen M, O'Brien P, O'Donohoe L, Payne H, Sundayi S, Walker E, Brooke J, Cardy J, Humphreys S, Kessack L, Kubitzek C, Kumar S, Cotterill D, Hodzovic E, Hosdurga G, Miles E, Saunders G, Campbell M, Chan P, Jemmett K, Raj A, Naik A, Oshowo A, Ramamoorthy R, Shah N, Sylvan A, Blyth K, Burtenshaw A, Freeman D, Johnson E, Lo P, Martin T, Plunkett E, Wollaston J, Allison J, Carroll C, Craw N, Craw S, Pitt-Kerby T, Rowland-Axe R, Spurdle K, McDonald A, Simon D, Sinha V, Smith T, Banner-Goodspeed V, Boone M, Campbell K, Lu F, Scannell J, Sobol J, Balajonda N, Clemmons K, Conde C, Elgasim M, Funk B, Hall R, Hopkins T, Olaleye O, Omer O, Pender M, Porto A, Stevens A, Waweru P, Yeh E, Bodansky D, Evans A, Kleopoulos S, Maril R, Mathney E, Sanchez A, Tinuoye E, Bateman B, Eng K, Jiang N, Ladha K, Needleman J, Chen LL, Lane R, Robinowitz D, Ghushe N, Irshad M, O'Connor J, Patel S, Takemoto S, Wallace A, Mazzeffi M, Rock P, Wallace K, Zhu X, Chua P, Mattera M, Sharar R, Thilen S, Treggiari M, Morgan A, Sofjan I, Subramaniam K, Avidan M, Maybrier H, Muench M, Wildes T., Université de Lille, CHU Lille, Queen Mary University of London [QMUL], Graduate School, Medical Microbiology and Infection Prevention, Clinical Immunology and Rheumatology, 01 Internal and external specialisms, ACS - Heart failure & arrhythmias, AGEM - Endocrinology, metabolism and nutrition, APH - Quality of Care, ACS - Diabetes & metabolism, AII - Amsterdam institute for Infection and Immunity, ACS - Microcirculation, Pearse, R M, International Surgical Outcomes Study (ISO), Group, Zangrillo, A, Landoni, G, Beretta, L., International Surgical Outcomes Study (ISOS) group, Pearse, R.M., Beattie, S., Clavien, P.A., Demartines, N., Fleisher, L.A., Grocott, M., Haddow, J., Hoeft, A., Holt, P., Moreno, R., Pritchard, N., Rhodes, A., Wijeysundera, D., Wilson, M., Ahmed, T., Everingham, K., Hewson, R., Januszewska, M., Phull, M.K., Halliwell, R., Shulman, M., Myles, P., Schmid, W., Hiesmayr, M., Wouters, P., de Hert, S., Lobo, S., Fang, X., Rasmussen, L., Futier, E., Biais, M., Venara, A., Slim, K., Sander, M., Koulenti, D., Arvaniti, K., Chan, M., Kulkarni, A., Chandra, S., Tantri, A., Geddoa, E., Abbas, M., Della Rocca, G., Sivasakthi, D., Mansor, M., Luna, P., Bouwman, A., Buhre, W., Beavis, V., Campbell, D., Short, T., Osinaike, T., Matos, R., Grigoras, I., Kirov, M., Protsenko, D., 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Sun, Y., Wang, Y., Zhang, M., Chen, R., Hou, J., Leng, Y., Meng, Q.T., Qian, L., Shen, Z.Y., Xia, Z.Y., Xue, R., Zhao, B., Zhou, X.J., Chen, Q., Guo, H., Guo, Y., Qi, Y., Wei, J., Zhang, W., Zheng, L., Bao, Q., Fei, Y., Hu, N., Hu, X., Lei, M., Lv, X., Miao, F., Ouyang, L., Shen, C., Wang, D., Wu, C., Xu, L., Yuan, J., Zhang, L., Zhang, H., Zhao, J., Zhao, C., Zhao, L., Zheng, T., Zhou, D., Zhou, C., Lu, K., Zhao, T., He, C., Chen, H., Chen, S., Cheng, B., He, J., Jin, L., Li, C., Li, H., Pan, Y., Shi, Y., Wen, X.H., Wu, S., Xie, G., Zhang, K., Lu, X., Chen, F., Liang, Q., Lin, X., Ling, Y., Liu, G., Tao, J., Yang, L., Cheng, Z., Dai, H., Feng, Y., Hou, B., Gong, H., Hu, C.H., Huang, H., Huang, J., Jiang, Z., Li, M., Lin, J., Liu, M., Liu, W., Luo, F., Ma, L., Min, J., Shi, X., Song, Z., Wan, X., Xiong, Y., Yang, S., Zhang, Q., Zhao, W., Zhu, X., Bai, Y., Dai, Q., Geng, W., Han, K., He, X., Ji, B., Jia, D., Jin, S., Li, Q., Liang, D., Luo, S., Lwang, L., Mo, Y., Qi, X., Qian, M., Qin, J., Ren, Y., Xie, J., Yan, Y., Yao, Y., Zhuang, X., Ai, Y., Du, F., He, L., Li, Z., Li, L., Meng, S., Yuan, Y., Zhang, E., Zhang, J., Zhao, S., Ji, Z., Pei, L., Dong, B., Li, J., Miao, Z., Mu, H., Qin, C., Su, L., Wen, Z., Xie, K., Yu, Y., Yuan, F., Xiao, W., Zhu, Z., Fu, K., Hu, R., Huang, S., Liang, Y., Yu, S., Guo, Z., Jing, Y., Tang, N., Wu, J., Yuan, D., Zhang, R., Zhao, X., Bai, H.P., Liu, C.X., Liu, F.F., Ren, W., Wang, X.L., Xu, G.J., Li, B., Ou, Y., Tang, Y., Yao, S., Zhang, S., Kong, C.C., Liu, B., Wang, T., Lu, B., Xia, Y., Cai, F., Chen, P., Hu, S., Xu, Q., Hu, L., Jing, L., Liu, Q., Peng, Z.D., Qiu, X., Ren, Q., Tong, Y., Wen, Y., Wu, Q., Xia, J., Xiong, X., Xu, S., Yang, T., Yin, N., Zeng, Q., Zhang, B., Zheng, K., Cang, J., Fan, Y., Fu, S., Ge, X., Guo, B., Huang, W., Jiang, L., Jiang, X., Shan, Q., Wang, F., Christiansen, I.C., Granum, S.N., Rasmussen, B.S., Daugaard, M., Gambhir, R., Brandsborg, B., Steingrímsdóttir, G.E., Jensen-Gadegaard, P., Olsen, K.S., Siegel, H., Eskildsen, K.Z., Gätke, M.R., Wibrandt, I., Heintzelmann, S.B., Wiborg Lange, K.H., Lundsgaard, R.S., Amstrup-Hansen, L., Hovendal, C., Larsen, M., Lenstrup, M., Kobborg, T., Larsen, J.R., Pedersen, A.B., Smith, S.H., Oestervig, R.M., Afshari, A., Andersen, C., Ekelund, K., Secher, E.L., Beloeil, H., Lasocki, S., Ouattara, A., Sineus, M., Molliex, S., Legouge, M.L., Wallet, F., Tesniere, A., Gaudin, C., Lehur, P., Forsans, E., de Rudnicki, S., Maudet, V.S., Mutter, D., Sojod, G., Ouaissi, M., Regimbeau, J.M., Desbordes, J., Comptaer, N., Manser, D.E., Ethgen, S., Lebuffe, G., Auer, P., Härtl, C., Deja, M., Legashov, K., Sonnemann, S., Wiegand-Loehnert, C., Falk, E., Habicher, M., Angermair, S., Laetsch, B., Schmidt, K., Von Heymann, C., Ramminger, A., Jelschen, F., Pabel, S., Weyland, A., Czeslick, E., Gille, J., Malcharek, M., Sablotzki, A., Lueke, K., Wetzel, P., Weimann, J., Lenhart, F.P., Reichle, F., Schirmer, F., Hüppe, M., Klotz, K., Nau, C., Schön, J., Mencke, T., Wasmund, C., Bankewitz, C., Baumgarten, G., Fleischer, A., Guttenthaler, V., Hack, Y., Kirchgaessner, K., Männer, O., Schurig-Urbaniak, M., Struck, R., van Zyl, R., Wittmann, M., Goebel, U., Harris, S., Veit, S., Andreadaki, E., Souri, F., Katsiadramis, I., Skoufi, A., Vasileiou, M., Aimoniotou-Georgiou, E., Katsourakis, A., Veroniki, F., Vlachogianni, G., Petra, K., Chlorou, D., Oloktsidou, E., Ourailoglou, V., Papapostolou, K., Tsaousi, G., Daikou, P., Dedemadi, G., Kalaitzopoulos, I., Loumpias, C., Bristogiannis, S., Dafnios, N., Gkiokas, G., Kontis, E., Kozompoli, D., Papailia, A., Theodosopoulos, T., Bizios, C., Koutsikou, A., Moustaka, A., Plaitakis, I., Armaganidis, A., Christodoulopoulou, T., Lignos, M., Theodorakopoulou, M., Asimakos, A., Ischaki, E., Tsagkaraki, A., Zakynthinos, S., Antoniadou, E., Koutelidakis, I., Lathyris, D., Pozidou, I., Voloudakis, N., Dalamagka, M., Elena, G., Chronis, C., Manolakaki, D., Mosxogiannidis, D., Slepova, T., Tsakiridou, I.S., Lampiri, C., Vachlioti, A., Panagiotakis, C., Sfyras, D., Tsimpoukas, F., Tsirogianni, A., Axioti, E., Filippopoulos, A., Kalliafa, E., Kassavetis, G., Katralis, P., Komnos, I., Pilichos, G., Ravani, I., Totis, A., Apagaki, E., Efthymiadi, A., Kampagiannis, N., Paraforou, T., Tsioka, A., Georgiou, G., Vakalos, A., Bairaktari, A., Charitos, E., Markou, G., Niforopoulou, P., Papakonstantinou, N., Tsigou, E., Xifara, A., Zoulamoglou, M., Gkioni, P., Karatzas, S., Kyparissi, A., Mainas, E., Papapanagiotou, I., Papavasilopoulou, T., Fragandreas, G., Georgopoulou, E., Katsika, E., Psarras, K., Synekidou, E., Verroiotou, M., Vetsiou, E., Zaimi, D., Anagnou, A., Apostolou, K., Melissopoulou, T., Rozenberg, T., Tsigris, C., Boutsikos, G., Kalles, V., Kotsalas, N., Lavdaiou, C., Paikou, F., Panagou, G.L., Spring, A., Botis, I., Drimala, M., Georgakakis, G., Kiourtzieva, E., Ntouma, P., Prionas, A., Xouplidis, K., Dalampini, E., Giannaki, C., Iasonidou, C., Ioannidis, O., Lavrentieva, A., Papageorgiou, G., Kokkinoy, M., Stafylaraki, M., Gaitanakis, S., Karydakis, P., Paltoglou, J., Ponireas, P., Chaloulis, P., Provatidis, A., Sousana, A., Gardikou, V.V., Konstantivelli, M., Lataniotou, O., Lisari, E., Margaroni, M., Stamatiou, K., Nikolaidis, E., Pnevmatikos, I., Sertaridou, E., Andreou, A., Arkalaki, E., Athanasakis, E., Chaniotaki, F., Chatzimichali, C.A., Christofaki, M., Dermitzaki, D., Fiorentza, K., Frantzeskos, G., Geromarkaki, E., Kafkalaki, K., Kalogridaki, M., Karydi, K., Kokkini, S., Kougentakis, G., Lefaki, T., Lilitsis, E., Makatounaki, A., Malliotakis, P., Michelakis, D., Neonaki, M., Nyktari, V., Palikyra, I., Papadakis, E., Papaioannou, A., Sfakianakis, K., Sgouraki, M., Souvatzis, X., Spartinou, A., Stefanidou, N., Syrogianni, P., Tsagkaraki, G., Arnaoutoglou, E., Arnaoutoglou, C., Bali, C., Bouris, V., Doumos, R., Gkini, K.P., Kapaktsi, C., Koulouras, V., Lena, A., Lepida, D., Michos, E., Papadopoulos, D., Paschopoulos, M., Rompou, V.A., Siouti, I., Tsampalas, S., Ververidou, O., Zilis, G., Charlalampidoy, A., Christodoulidis, G., Flossos, A., Stamoulis, K., Tsang, MSC, Tsang, M.S., Lai, M.L., Yip, C.P., Heymans Chan, H.M., Law, B., Li, W.S., Chu, H.M., Koo, EGY, Lam, CCJ, Cheng, K.H., Lam, T., Chu, S., Lam, W.Y., Wong, KWK, Kwok, D., Hung, CYJ, Chan, WKJ, Wong, W.L., Chung, CKE, Ma, S.K., Kaushik, S., Shah, B., Shah, D., Shah, S., Ar, P., Muthuchellappan, R., Agarwal, V., Divatia, J., Mishra, S., Nimje, G., Pande, S., Savarkar, S., Shrivastava, A., Thomas, M., Yegnaram, S., Hidayatullah, R., Puar, N., Niman, S., Indra, I., Hamzah, Z., Yuliana, A., Abidin, U.N., Dursin, A.N., Kurnia, A., Susanti, A., Handayani, D., Alit, M.A., Arya, A., Senapathi, TGA, Utara, U.H., Wid, W.M., Wima, S., Wir, W.M., Jehosua, B., Kaunang, J., Lantang, E.Y., Najoan, R., Waworuntu, N., Awad, H., Fuad, A., Geddoa, B., Khalaf, A.R., Al Hussaini, S., Albaj, S., Kenber, M., Bettinelli, A., Spadaro, S., AlbertoVolta, C., Giancarlo, L., Sottosanti, V., Copetti, E., Spagnesi, L., Toretti, I., Alloj, C., Cardellino, S., Carmino, L., Costanzo, E., Fanfani, L.C., Novelli, M.T., Roasio, A., Bellandi, M., Bignami, E., Bocchino, S., Cabrini, L., Corti, D., Landoni, G., Meroni, R., Moizo, E., Monti, G., Pintaudi, M., Plumari, V.P., Taddeo, D., Testa, V., Winterton, D., Zangrillo, A., Cloro, L.M., Colangelo, C., Colangelo, A., Rotunno, G., Paludi, M.A., Maria, C.P., Pata, A., Parrini, V., Gatta, A., Nastasi, M., Tinti, C., Baroselli, A., Arrigo, M., Benevento, A., Bottini, C., Cannavo', M., Gastaldi, C., Marchesi, A., Pascazio, A., Pata, F., Pozzi, E., Premoli, A., Tessera, G., Boschi, L., D'Andrea, R., Ghignone, F., Poggioli, G., Sibilio, A., Taffurelli, M., Ugolini, G., Ab Majid, M.A., Ab Rahman, R., Joseph, J., Pathan, F., Sybil Shah, M.H., Yap, H.L., Cheah, S., Chin, I.I., Looi, J.K., Tan, S.C., Visvalingam, S., Kwok, F.Y., Lee, C.K., Tan, T.S., Wong, S.M., Abdullah, N.H., Liew, C.F., Luxuman, L., Mohd Zin, N.H., Norddin, M.F., Raja Alias, R.L., Wong, J.Y., Yong, J., Bin 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E., Hosdurga, G., Miles, E., Saunders, G., Campbell, M., Chan, P., Jemmett, K., Raj, A., Naik, A., Oshowo, A., Ramamoorthy, R., Shah, N., Sylvan, A., Blyth, K., Burtenshaw, A., Freeman, D., Johnson, E., Lo, P., Martin, T., Plunkett, E., Wollaston, J., Allison, J., Carroll, C., Craw, N., Craw, S., Pitt-Kerby, T., Rowland-Axe, R., Spurdle, K., McDonald, A., Simon, D., Sinha, V., Banner-Goodspeed, V., Boone, M., Campbell, K., Lu, F., Scannell, J., Sobol, J., Balajonda, N., Clemmons, K., Conde, C., Elgasim, M., Funk, B., Hopkins, T., Olaleye, O., Omer, O., Pender, M., Porto, A., Waweru, P., Yeh, E., Bodansky, D., Evans, A., Kleopoulos, S., Maril, R., Mathney, E., Sanchez, A., Tinuoye, E., Bateman, B., Eng, K., Jiang, N., Ladha, K., Needleman, J., Chen, L.L., Lane, R., Robinowitz, D., Ghushe, N., Irshad, M., O'Connor, J., Patel, S., Takemoto, S., Wallace, A., Mazzeffi, M., Rock, P., Wallace, K., Chua, P., Mattera, M., Sharar, R., Thilen, S., Treggiari, M., Morgan, A., Sofjan, I., Subramaniam, K., Avidan, M., Maybrier, H., Muench, M., and Wildes, T.
Subjects: Male, Postoperative Complications/epidemiology, Hospital mortality, [SDV]Life Sciences [q-bio], surgery, Postoperative Complications, 0302 clinical medicine, cohort studies, 030202 anesthesiology, patient safety, 030212 general & internal medicine, Postoperative Period, Medicine(all), Middle Aged, Checklist, 3. Good health, Treatment Outcome, operative/mortality, Elective Surgical Procedures, Surgical Procedures, Operative, Meta-analysis, Cohort, Cohort studies, Female, Elective Surgical Procedure, postoperative care/methods, postoperative care/statistics and numerical data, surgical procedures, Anesthesiology and Pain Medicine, Cohort study, Adult, medicine.medical_specialty, Evidence-based medicine, NO, 03 medical and health sciences, Patient safety, medicine, postoperative care/method, Humans, Elective Surgical Procedures/standards, Aged, Cohort Studies, Evidence-Based Medicine, Hospital Mortality, Patient Safety, Postoperative Complications/mortality, Postoperative Complications/prevention & control, Surgical Procedures, Operative/methods, business.industry, Odds ratio, Surgery, Observational study, business, cohort studie
Abstract: BACKGROUND: The surgical safety checklist is widely used to improve the quality of perioperative care. However, clinicians continue to debate the clinical effectiveness of this tool.METHODS: Prospective analysis of data from the International Surgical Outcomes Study (ISOS), an international observational study of elective in-patient surgery, accompanied by a systematic review and meta-analysis of published literature. The exposure was surgical safety checklist use. The primary outcome was in-hospital mortality and the secondary outcome was postoperative complications. In the ISOS cohort, a multivariable multi-level generalized linear model was used to test associations. To further contextualise these findings, we included the results from the ISOS cohort in a meta-analysis. Results are reported as odds ratios (OR) with 95% confidence intervals.RESULTS: We included 44 814 patients from 497 hospitals in 27 countries in the ISOS analysis. There were 40 245 (89.8%) patients exposed to the checklist, whilst 7508 (16.8%) sustained ≥1 postoperative complications and 207 (0.5%) died before hospital discharge. Checklist exposure was associated with reduced mortality [odds ratio (OR) 0.49 (0.32-0.77); PCONCLUSIONS: Patients exposed to a surgical safety checklist experience better postoperative outcomes, but this could simply reflect wider quality of care in hospitals where checklist use is routine.
Published: 2018

124. 4.52 LIFETIME PSYCHOPATHOLOGY IN CHILD AND ADOLESCENT OFFSPRING OF PARENTS DIAGNOSED WITH SCHIZOPHRENIA OR BIPOLAR DISORDER: A TWO-YEAR FOLLOW-UP STUDY

Author: Inmaculada Baeza, Ana Espliego, Elena de la Serna, Josefina Castro-Fornieles, Elisa Rodríguez, Gisela Sugranyes, Soledad Romero, Daniel Ilzarbe, Dolores Moreno, and Miriam Ayora
Subjects: medicine.medical_specialty, business.industry, Offspring, Follow up studies, medicine.disease, Child and adolescent, Psychiatry and Mental health, Schizophrenia, Developmental and Educational Psychology, medicine, Bipolar disorder, business, Psychiatry, Psychopathology
Published: 2019

125. Baseline neurofunctional predictors of improvement in self-harming behaviors in adolescents before and after group therapy

Author: Manpreet K. Singh, Elena Moreno, Sara M. Leslie, Melissa Packer, Marisol Picado, Esteve Martínez, Pilar Santamarina-Perez, Iria Mendez, Elena Font, Soledad Romero, and Astrid Morer
Subjects: Pharmacology, medicine.medical_specialty, business.industry, medicine.medical_treatment, Group psychotherapy, Psychiatry and Mental health, Neurology, Physical therapy, medicine, Pharmacology (medical), Neurology (clinical), Baseline (configuration management), business, Biological Psychiatry
Published: 2019

126. Cortical thickness in subjects twenty years after diagnosis of anorexia nervosa during adolescence

Author: Núria Bargalló, Jose C. Pariente, Anna Calvo, Soledad Romero, Josefina Castro-Fornieles, Miguel Gárriz, Susana Andrés-Perpiñá, E. De la Serna, Itziar Flamarique, and Maria Teresa Plana
Subjects: Pharmacology, Psychiatry and Mental health, Pediatrics, medicine.medical_specialty, Neurology, business.industry, Anorexia nervosa (differential diagnoses), Medicine, Pharmacology (medical), Neurology (clinical), business, Biological Psychiatry
Published: 2019

127. Four year follow-up of offspring of schizophrenia and bipolar patients: Measures of brain morphology and their relationship with emerging psychosis

Author: D. Ilzarbe, Dolores Moreno, Vanessa Sánchez-Gistau, Immaculada Baeza, Soledad Romero, G. Sugranyes, E. De la Serna, Jose C. Pariente, and Josefina Castro-Fornieles
Subjects: Pharmacology, Psychosis, medicine.medical_specialty, business.industry, Offspring, Brain morphometry, medicine.disease, Psychiatry and Mental health, Neurology, Schizophrenia, medicine, Pharmacology (medical), Neurology (clinical), business, Psychiatry, Biological Psychiatry
Published: 2019

128. Neuropsychological characteristics of children and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder

Author: J. Castro-Fonieles, Elisa Rodríguez-Toscano, G. Sugranyes, Dolores Moreno, I. Baeza-Pertegaz, Carmen Moreno, Soledad Romero, and E. De la Serna
Subjects: Pharmacology, medicine.medical_specialty, business.industry, Neuropsychology, medicine.disease, Psychiatry and Mental health, Neurology, Schizophrenia, Adolescent offspring, Medicine, Pharmacology (medical), Neurology (clinical), Bipolar disorder, business, Psychiatry, Biological Psychiatry
Published: 2019

129. Depeche Mode (Band Records)

Author: Soledad Romero Mariño, Fernando López del Hierro, Soledad Romero Mariño, and Fernando López del Hierro
Abstract: Los inicios de Depeche Mode, la banda de rock electrónico por excelencia, explicada a los más pequeños. Synth pop, dance rock, new wave... Con su estilo único, el grupo británico Depeche Mode revolucionó la escena musical electrónica en los ochenta. Precursores del uso del sintetizador como instrumento, Vince Clarke, Dave Gahan, Martin Gore y Andy Fletcher se convirtieron a golpe de sampler en un auténtico fenómeno de masas. Responsables de hits como «Enjoy the silence» o «Precious», sus influencias resuenan en grupos como los Pet Shop Boys o Coldplay.
Published: 2018

130. Psychiatric disorders in child and adolescent offspring of patients with schizophrenia and bipolar disorder: A controlled study

Author: Soledad Romero, Elena de la Serna, Gisela Sugranyes, Dolores Moreno, Josefina Castro-Fornieles, Inmaculada Baeza, Elisa Rodríguez-Toscano, Carmen Moreno, Vanessa Sánchez-Gistau, and Teresa Sánchez-Gutiérrez
Subjects: Adult, Male, medicine.medical_specialty, Bipolar Disorder, Adolescent, Offspring, Severity of Illness Index, Child of Impaired Parents, Interview, Psychological, Severity of illness, Prevalence, medicine, Humans, Attention deficit hyperactivity disorder, Bipolar disorder, Child, Psychiatry, Biological Psychiatry, Depression (differential diagnoses), Siblings, Middle Aged, medicine.disease, Mental health, Psychiatry and Mental health, Attention Deficit Disorder with Hyperactivity, Schizophrenia, Multivariate Analysis, Female, Psychology, Psychopathology, Clinical psychology
Abstract: Background Early clinical manifestations predating schizophrenia (SZ) and bipolar disorder (BP) have not been fully characterized. Child offspring studies are a valuable opportunity to study the natural history of the illness from its earliest stages. However, there is limited evidence assessing young offspring of SZ and BP simultaneously. We set out to assess rates of psychiatric disorders in child and adolescent offspring of SZ and BP, relative to offspring of community controls, so as to characterize the early phenotype of the disorders comparatively. Methods SZ and BP parents with offspring aged 7–17 years were recruited through adult mental health services of two tertiary hospitals. Community control (CC) parents were recruited from the same geographical area. Ninety BP-offspring, 41 SZ-offspring and 107 CC-offspring were assessed using the K-SADS-PL by child psychiatrists blinded to parental status. Differences in prevalence of psychiatric disorders between groups were adjusted for confounders and for sibling correlation using generalised estimating equations. Results We found a gradient of clinical severity and social disadvantage between SZ, BP and CC-offspring. After adjusting for socio-demographic confounders, SZ and BP-offspring presented higher rates of attention deficit hyperactivity disorder (ADHD) than CC-offspring. ADHD was more prevalent in SZ-offspring than BP-offspring, and BP-offspring presented a higher prevalence of depression than CC-offspring. Conclusions The higher rates of ADHD in SZ-offspring suggest that abnormal neurodevelopmental processes may exert a stronger influence in SZ than BP. Follow-up of these children will help elucidate the role of ADHD and depression phenotypes in predicting future transition to SZ or BP.
Published: 2015

131. Metallica (Band Records)

Author: Soledad Romero Mariño, David Navas, Soledad Romero Mariño, and David Navas
Abstract: La historia de METALLICA, el legendario grupo de Thrash Metal, explicada a los más pequeños. La fascinante historia de Metallica empieza en Los Ángeles, cuando Lars Ulrich, una promesa del tenis mundial, abandona su carrera para montar una banda Metal y convertirse en el mejor baterista del mundo. Cuando puso un anuncio en una revista para encontrar compañeros de banda interesados en los sonidos de Motorhëad e Iron Maiden, apareció James Hetfield, guitarrista y cantante con alguna experiencia en otros grupos. Al poco se les unieron Dave Mustain y Cliff Burton para completar la formación y conquistar el feroz mundo del Metal. Metallica es un cuento que derrocha los valores que el Rock ha dejado a toda una generación: libertad, coraje, independencia y lealtad a uno mismo.
Published: 2017

132. Ramones (Band Records)

Author: Joe Padilla, Soledad Romero Mariño, Joe Padilla, and Soledad Romero Mariño
Abstract: Los Ramones explicados a tus hijos. La increíble historia de cuatro amigos que se convirtieron en leyendas del punk rock. Si hay una historia universal de superación esa es la de los Ramones. Y sirve y gusta a todo el mundo. Cuatro chavales de Queens lograron el éxito sin saber apenas tocar un instrumento. ¿Su secreto? El amor por la música y la cultura de serie B. Joey, Johnny, Dee Dee y Tommy Ramone son los nombres artísticos de estos cuatro «hermanos» del barrio de Forest Hills, en Queens, que montaron en 1974 su primera formación sin saber que estaban a la vanguardia musical mundial. Tras dos años de tocar en garitos de mala muerte y medio triunfar en la sala de moda neoyorquina, el CBGB, los fichó la discográfica Sire para grabar su primer álbum, el homónimo Ramones. De ahí al mítico concierto en la sala Roundhouse de Londres en julio de 1976 mediaron unos pocos meses. Podría decirse que dieron el pistoletazo mundial al punk: recibieron en el backstage a grupos que por entonces empezaban, como los Clash o los Sex Pistols. Los inicios de la banda, hasta su primera consagración, están contados en este álbum al alcance de todos los niños y mayores. Una historia de amistad y superación como nunca la has visto. Y más cool que nunca. Reseña: «Abrir el libro Ramones (ilustrado y de pequeño formato) es abrir el baúl de los recuerdos de aquellos chavales que en los 70 llevaban un característico corte depelo. Flequillo largo que tapaba los ojos. Un peinado que marcó a una tribu: los punk.» Carmen Carbonell, Libertad Digital
Published: 2017

133. Diagnostic performance of the indirect immunofluorescence test for the detection of antibodies against HTLV-1

Author: Ronal Briceño-Espinoza, Soledad Romero-Ruiz, and Eduardo Miranda-Ulloa
Subjects: Gynecology, medicine.medical_specialty, Human T-lymphotropic virus 1, Indirect immunofluorescence, medicine.diagnostic_test, biology, business.industry, Diagnóstico, Public Health, Environmental and Occupational Health, General Medicine, Repeatability, Técnica del anticuerpo fluorescente indirecta, Immunofluorescence, Diagnostic test evaluation, indirect, Kappa index, Reference test, Fluorescent antibody technique, Diagnosis, False positive paradox, biology.protein, Virus 1 linfotrópico T humano, Medicine, Antibody, business
Abstract: El objetivo del estudio fue determinar el rendimiento diagnóstico de la prueba de inmunofluorescencia indirecta (IFI) para la detección de anticuerpos contra HTLV-1. Se realizó un estudio de evaluación de prueba diagnóstica. Se usaron cultivos celulares MT2 infectados con HTLV-1 y K-562 sin infección, luego fueron sembrados, fijados en láminas para inmunofluorescencia y enfrentados a sueros. Se usaron 155 sueros (80 positivos para HTLV-1 y 75 positivos para otras enfermedades) procedentes de la seroteca del Instituto Nacional de Salud del Perú. Adicionalmente, se evaluó la repetibilidad (en el laboratorio) y reproducibilidad (en laboratorios de costa, sierra y selva) de la prueba. La prueba IFI para la detección de anticuerpos contra HTLV-1 tuvo una sensibilidad de 98,75% (IC 95%: 95,69-100%), una especificidad de 98,67% (IC 95%: 95,40-100%) y el índice de kappa de 0,975. No hubo falsos positivos ni falsos negativos; sin embargo, sí se obtuvo un resultado indeterminado y uno inespecífico. La prueba mostró 100% de concordancia en la repetibilidad y reproductibilidad. Concluimos que los resultados obtenidos son comparables a la prueba de referencia. La prueba de IFI presenta un buen rendimiento diagnóstico y sería de utilidad para la confirmación de HTLV-1. The objective of the study was to determine the diagnostic yield of the indirect immunofluorescence (IFI) test for the detection of antibodies against HTLV-1. A diagnostic test evaluation study was performed. HTLV-1-infected MT2 cells and HTLV-1-uninfected K-562 cells were cultured; then these cells were impregnated and fixed in sheets for immunofluorescence and faced to Peruvian sera. A total of 155 sera (80 HTLV-1-positive sera and 75 sera positive for other diseases) from the Peruvian Instituto Nacional de Salud were used. In addition, the parameters of repeatability (intra-laboratory) and reproducibility (in laboratories of the Peruvian coast, mountains and jungle) of the test were evaluated. The IFI test detected the presence of antibodies against HTLV-1 reaching a sensitivity of 98.75% (95% CI: 95.69 - 100.00%), a specificity of 98.67% (95% CI: 95.40 - 100.00%) and the Kappa index was 0.975. There were no false positives or false negatives; however, one undetermined result and one non-specific result were obtained. The test showed 100% qualitative agreement when performing the repeatability and reproducibility. The results obtained are comparable to the reference test. Therefore, the IFI test had a good diagnostic performance and would be useful for the confirmation of HTLV-1.
Published: 2017

134. A study on the bioequivalence of lithium and valproate salivary and blood levels in the treatment of bipolar disorder

Author: Mercè Torra, A. Callari, Eduard Vieta, Jose Manuel Goikolea, Víctor Pérez-Sola, F. Colom, Andrea Murru, Isabella Pacchiarotti, C. Varo, Soledad Romero, and B. Gonzalez de la Presa
Subjects: Adult, Male, medicine.medical_specialty, Saliva, Bipolar Disorder, Lithium (medication), Trastorn bipolar -- Tractament, Bioequivalence, Lithium, Gastroenterology, Treatment of bipolar disorder, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Lack of efficacy, Bipolar disorders, Humans, Pharmacology (medical), Bipolar disorder, Serum levels, Biological Psychiatry, Salivary, Pharmacology, Psychiatric Status Rating Scales, Valproic Acid, Valproate, business.industry, Middle Aged, medicine.disease, Antidepressive Agents, 030227 psychiatry, Psychiatry and Mental health, Endocrinology, Neurology, chemistry, Therapeutic Equivalency, Lithium chloride, Female, lipids (amino acids, peptides, and proteins), Neurology (clinical), business, Lithium Chloride, 030217 neurology & neurosurgery, medicine.drug
Abstract: Lithium (Li) and valproate (VPA) are used in the treatment of bipolar disorder (BD), with narrow therapeutic window requiring periodic control of serum levels. This prevents intoxication, lack of efficacy due to low serum concentrations, and allows monitoring adherence. We aimed at evaluating the bioequivalence of salivary and blood levels of LI or VPA in a sample of adult BD patients. Secondarily, lithium bioequivalence was evaluated across different patients' lifespans. BD patients treated with either Li or VPA underwent contemporary standard serum and salivary measurements. Blood levels of both drugs were taken according to standard procedures. Li salivary levels were performed by an adapted potentiometric method on the AVL9180 electrolyte analyzer. VPA salivary levels were taken with an immune-assay method with turbidimetric inhibition. A total of 50 patients (38 on Li, 12 on VPA) were enrolled. Blood-saliva bioequivalence for VPA was not found due to a high variability in salivary measures. Li measures resulted in a high correlation (r=0.767, p
Published: 2017

135. Clinical, Cognitive, and Neuroimaging Evidence of a Neurodevelopmental Continuum in Offspring of Probands With Schizophrenia and Bipolar Disorder

Author: Elisa Rodríguez-Toscano, Inmaculada Baeza, Roger Borràs, Miguel Bernardo, Covadonga M. Díaz-Caneja, Eduard Vieta, Dolores Moreno, Soledad Romero, Josefina Castro-Fornieles, Vanessa Sánchez-Gistau, Gisela Sugranyes, Jose C. Pariente, Carmen Moreno, and Elena de la Serna
Subjects: Proband, relatives, Male, Bipolar Disorder, Adolescent, Offspring, Cross-sectional study, Intelligence, Neuroimaging, behavioral disciplines and activities, 03 medical and health sciences, 0302 clinical medicine, Child of Impaired Parents, Pregnancy, mental disorders, medicine, Humans, Bipolar disorder, Gray Matter, Child, bipolar disorder, neuroimaging, business.industry, neurodevelopmental disorders, medicine.disease, 030227 psychiatry, Obstetric Labor Complications, schizophrenia, Psychiatry and Mental health, Cross-Sectional Studies, Schizophrenia, Female, business, Neurocognitive, 030217 neurology & neurosurgery, Clinical psychology, Regular Articles
Abstract: Background Studies in child and adolescent offspring of patients with schizophrenia or bipolar disorders may help understand the influence of neurodevelopmental factors on the premorbid phenotype of these disorders. Aims To assess whether a combination of neurodevelopmental factors discriminates between young offspring of patients with schizophrenia (SzO) or bipolar disorder (BpO) and community controls (CcO). To assess the association between these factors and rates of psychiatric diagnoses in high risk (HR) youth. Methods One hundred thirty-three HR offspring (47 SzO and 86 BpO) and 84 CcO, aged 6-17, underwent cross-sectional clinical, neurocognitive, and structural neuroimaging assessment. Information on perinatal events and early childhood development was also obtained. General linear mixed models were performed to assess group discrimination and association with lifetime axis I psychiatric disorders. Results Multivariate analyses revealed that greater neurological soft signs (NSS), less total grey matter volume (GMV) and a higher frequency of obstetric complications discriminated HR offspring from CcO. When comparing each group individually, greater NSS and a higher frequency of obstetric complications discriminated SzO from CcO, and BpO from CcO, while lower intelligence also discriminated SzO from CcO and from BpO. Within HR offspring, lower intelligence and less total GMV were associated with lifetime incidence of psychiatric disorders. Conclusions Both SzO and BpO showed evidence of neurodevelopmental insult, although this may have a greater impact in SzO. Lower intelligence and less total GMV hold potential as biomarkers of risk for psychiatric disorders in HR youth.
Published: 2017

136. Sleep study in Disruptive Mood Dysregulation Disorder and Bipolar children

Author: Xavier, Estrada-Prat, Ion, Álvarez-Guerrico, María J, Bleda-Hernández, Ester, Camprodon-Rosanas, Santiago, Batlle-Vila, Elena, Pujals-Altes, María T, Nascimento-Osorio, Luís M, Martín-López, Enric, Álvarez-Martínez, Víctor, Pérez-Solá, and Soledad, Romero-Cela
Subjects: Male, Bipolar Disorder, Cross-Sectional Studies, Adolescent, Attention Deficit Disorder with Hyperactivity, Mood Disorders, Polysomnography, Humans, Female, Child
Abstract: Decreased need for sleep has been proposed as a core symptom of mania and it has been associated with the pathogenesis of Bipolar Disorder. The emergence of Disruptive Mood Dysregulation Disorder (DMDD) as a new diagnostic has been controversial and much has been speculated about its relationship with the bipolar spectrum. REM sleep fragmentation could be a biomarker of affective disorders and it would help us to differentiate them from other disorders.Polysomnographic cross-sectional study of children with DMDD, bipolar disorder and Attention Deficit Hyperactivity Disorder (ADHD). All participants underwent a psychiatric semi-structured interview to obtain the diagnosis, comorbidities and primary sleep disorders. DMDD#8217;s sample was performed following DSM5 criteria.Perform polysomnography in a sample of bipolar, DMDD and ADHD children and compare their profiles to provide more evidence about the differences or similarities between bipolar disorder and DMDD.Bipolar group had the highest REM density values while ADHD had the lowest. REM density was not statiscally different between bipolar phenotypes. REM density was associated with antidepressant treatment, episodes of REM and their interaction. REM latency was associated with antipsychotic treatment and school performance. Bipolar patients had higher scores on the depression scale than DMDD and ADHD groups.No significant differences between the two compared affective disorders were found. However there were differences in REM density between bipolar and ADHD groups. REM sleep study could provide a new theoretical framework to better understand the pathogenesis of pediatric bipolar disorder.
Published: 2017

137. Spawning and larval development ofTegula euryomphala(Jones, 1844) (Trochoidea: Tegulidae) from La Herradura Bay, Chile

Author: María Soledad Romero Bastías
Subjects: Larva, biology, Vetigastropoda, Ecology, fungi, Zoology, Veliger, biology.organism_classification, Tegulidae, Tegula euryomphala, Protoconch, Animal Science and Zoology, Trochoidea (genus), Bay, Developmental Biology
Abstract: The spawning and larval development of Tegula euryomphala (Jones, 1844) were studied under laboratory conditions. The release of gametes was stimulated by raising temperature from 16 to 19 °C, and could be induced during several months of the year. Males always spawned first. Eggs were 155.6 μm in diameter and remained unattached to each other. Development was similar to that described for other Trochoidea and lasted 3–5 days at 19 °C. Larvae hatched approximately 24 h post-fertilization at the pre-torsional veliger stage. The larval protoconch of the metamorphic veliger measured 247 μm and was ornamented with six spiral threads and weakly ordered granulation. Larvae metamorphose without any natural substratum.
Published: 2014

138. Colaboradores

Author: Acosta Rodríguez, Víctor M., Diez, José Ángel Alda, Arroyo, Sonia Álvarez, Perpiñá, Susana Andrés, Diego, Cesar Antolín, Delgado, Pedro Avero, Pertegaz, Inmaculada Baeza, Tello, Itziar Baltasar, Fernández, Luis Beato, Andaluz, Rafaela Caballero, Escalona, Rosa Calvo, Diez, Tomás José Cantó, Bonet, Juan I. Capafóns, Belloso, Juan José Carballo, Notario, Lidia Carrillo, Rodríguez, Víctor G. Carrión, Fornieles, Josefina Castro, Aguilera, Marina Cayero, Moreno, M.ª Concepción Chinchilla, Sánchez, Francisco Collazos, Guerra, Juan Jairo David Ortiz, de la Serna Gómez, Elena, Lacosta, Carlos Delgado, Atienza, Francisco Díaz, Hurtado, Rosa Díaz, Abadía, Montserrat Dolz, Santos, M.ª Dolores Domínguez, González, Almudena Escudero, Jaime, José Carlos Espín, Aresté, Montserrat Esquerda, Prat, Xavier Estrada, Barrios, Mar Faya, Fernández, Jennifer Fernández, Rivas, Aranzazu Fernández, López, Eduard Forcadell, Herráez, David Fraguas, Fraile, Sabel Gabaldón, Castillo, Silvia Gadea del, Pérez, Xavier Gastaminza, Domenech, Pablo José González, Pérez, Pedro A. González, Riesco, Laura González, Rodríguez, Mireia González, Vallespí, Laura González, Elejalde, Javier Goti, Berna, Montserrat Graell, Casares, José Ramón Gutiérrez, Fernández, Noelia Gutiérrez, Priego, Silvia Gutiérrez, Expósito, Sergio Hernández, Otero, Isabel Hernández, Rodríguez, Óscar Herreros, Simorte, Daniel Ilzarbe, Roncero, Carlos Imaz, Eguren, Jon Izaguirre, Elvira, M.ª Luisa Joga, Lizeaga, Iñaki Kerexeta, García, M.ª Luisa Lázaro, Miguel, Sara Lera, Sarabia, Cloe Llorente, Moreno, Laura López, Gómez, Victoria Natalia Lozano, Castaño, Leticia Mallol, González, Raquel Martín, Díaz-Caneja, Covadonga Martínez, Luna, Francisco Ramón Martínez, Castro, José Mazaira, Blanco, Iria Méndez, Miranda-Viera, Delimar, Práxedes, M.ª Dolores Mojarro, Garrido, Cristina Molins, Rada, Francisco Montañés, Díaz, Josué Monzón, ª Moreno Pardillo, Dolores M., Ruiz, Carmen Moreno, Liñan, Astrid Morer, Canyelles, Jaume Morey, Martínez, Victoria Muñoz, Hernani, Kristian Naenen, García, Enrique Ortega, Villalobos, Aránzazu Ortiz, Cuesta, Soraya Otero, Maresca, Inmaculada Palanca, Corral, María Pardo, Gallego, Marta Pardo, Redondo, Mara Parellada, Aranda, Ana Pascual, González, Beatriz Payá, Álvarez, José Carlos Peláez, Antolín, Antonio Pelaz, Aranda, Sonia Pérez, Vigil, Ana Pérez, González, M.ª Dolores Picouto, Camacho, Laura Pina, Calderón, Francisco Javier Pino, Turró, M.ª Teresa Plana, Rangel, Diana Polo, López, Marian Pozuelo, Vidal, Joaquim Puntí, Santana, Gustavo Mario Ramírez, Gascón, Mar Ramos, Vidal, Carla Ramos, Šimić, Jasna Raventós, Real Dasí, Alberto, López, Matías Real, Ramos, Prudencio Rodríguez, Cela, Soledad Romero, Escobar, Helena Romero, González, Marina Romero, González, Miguel Romero, Morell, Belén Rubio, Lázaro, Pedro Manuel Ruiz, Sanz, Francisco Ruiz, Collazo, Nuria Sabaté, Cerezo, Javier Sánchez, Zazo, Elisa Seijo, Pardo, Eva Sesma, Sevilla-Cermeño, Laura, Mena, Sara Solera, Arimany, Mireia Solerdelcoll, Ernest, Gisela Sugranyes, Alonso, María Tajes, Poza, Kazuhiro Tajima, Trallero, Josep Toro, Salamanca, Nuria Tur, Moreno, M.ª del Mar Urán, Moreira, Rosario Vacas, Yapor, Manuel Valderrama, González, Ana Patricia Vázquez, Vizcaíno, Ernesto José Verdura, Sánchez, Isabel Vicente, Vidal de la Fuente, Jorge, Grifoll, Mar Vila, and Monterroso, Ángel Villaseñor
Published: 2021
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139. Consumo de bebidas alcohólicas según expectativas y contextos en adolescentes de Córdoba y Santiago del Estero, Argentina.

Author: LÓPEZ STEINMETZ, LORENA CECILIA, ÁNGELES ROSS, PAULA, DEL MILAGRO QUINTEROS, SOFÍA, LUPO, AGOSTINA PAULA, GÍANÍNA SOLEDAD ROMERO, and ANDRÉ RÍCARDO PÍACENTÍNÍ
Subjects: ALCOHOL drinking, TEENAGERS, NEUROSCIENCES, NERVOUS system, PARENTS
Abstract: Copyright of Acta Psiquiátrica y Psicológica de América Latina is the property of Acta Psiquiatrica y Psicologica de America Latina and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2020

140. New Subtypes and Genetic Recombination in HIV Type 1-Infecting Patients with Highly Active Antiretroviral Therapy in Peru (2008–2010)

Author: Soledad Romero, Gabriela Salinas, Cecilia Gazzo, Fanny Cárdenas, Maribel Acuña, Carlos Yábar, and Ada Valverde
Subjects: Adult, Male, Adolescent, Genotype, Molecular Sequence Data, Immunology, HIV Infections, Biology, Genetic recombination, law.invention, Plasma, Young Adult, HIV Protease, law, Antiretroviral Therapy, Highly Active, Virology, Drug Resistance, Viral, Peru, Genetic variation, Pathology, Humans, Polymerase chain reaction, Aged, Recombination, Genetic, Genetics, Genetic diversity, Phylogenetic tree, Genetic Variation, Sequence Analysis, DNA, Middle Aged, HIV Reverse Transcriptase, Reverse transcriptase, Infectious Diseases, HIV-1, RNA, Viral, Female, HIV drug resistance
Abstract: HIV-1 subtype B is the most frequent strain in Peru. However, there is no available data about the genetic diversity of HIV-infected patients receiving highly active antiretroviral therapy (HAART) here. A group of 267 patients in the Peruvian National Treatment Program with virologic failure were tested for genotypic evidence of HIV drug resistance at the Instituto Nacional de Salud (INS) of Peru between March 2008 and December 2010. Viral RNA was extracted from plasma and the segments of the protease (PR) and reverse transcriptase (RT) genes were amplified by reverse transcriptase polymerase chain reaction (RT-PCR), purified, and fully sequenced. Consensus sequences were submitted to the HIVdb Genotypic Resistance Interpretation Algorithm Database from Stanford University, and then aligned using Clustal X v.2.0 to generate a phylogenetic tree using the maximum likelihood method. Intrasubtype and intersubtype recombination analyses were performed using the SCUEAL program (Subtype Classification by Evolutionary ALgo-rithms). A total of 245 samples (91%) were successfully genotyped. The analysis obtained from the HIVdb program showed 81.5% resistance cases (n=198). The phylogenetic analysis revealed that subtype B was predominant in the population (98.8%), except for new cases of A, C, and H subtypes (n=4). Of these cases, only subtype C was imported. Likewise, recombination analysis revealed nine intersubtype and 20 intrasubtype recombinant cases. This is the first report of the presence of HIV-1 subtypes C and H in Peru. The introduction of new subtypes and circulating recombinants forms can make it difficult to distinguish resistance profiles in patients and consequently affect future treatment strategies against HIV in this country.
Published: 2012

141. Imposex in Thaisella chocolata (Duclos, 1832) (Gastropoda: Muricidae) Caldera Bay, Chile

Author: María Soledad Romero and Yasna Mattos
Subjects: Imposex, anatomy, 010504 meteorology & atmospheric sciences, Thais chocolata, Muricidae, imposex, Thaisella chocolata, 010501 environmental sciences, Aquatic Science, Biology, Oceanography, biology.organism_classification, 01 natural sciences, reproduction, tributyltin, histopathology, TBT, Humanities, 0105 earth and related environmental sciences
Abstract: El imposex es la superimposicion de pseudopene y vaso deferente en el sistema reproductor de las hembras de gasteropodos. Esta virilizacion se atribuye a un desbalance hormonal inducido por el tributilestano (TBT), un compuesto organoestanoso, presente en las pinturas anti-incrustantes. Este estudio analiza la severidad, proporcion, grados e indices de imposex en una poblacion de Thaisella chocolata de Bahia Caldera, Chile. El sexo se determino por biopsia de la gonada de 180 ejemplares y el imposex por la concurrencia de ovario, glandula de la capsula, vaso deferente y pseudopene en hembras anormales. La proporcion de hembras afectadas se estimo a traves de la formula de Gibbs et al. (1987). Se clasifico el grado del sindrome aplicando cinco escalas y se calcularon los Indices del Estado del Vaso Deferente (VDSI), Longitud Relativa del Pene (RPLI) y Tamano Relativo del Pene (RPSI). Los resultados muestran que el 100% de las hembras de T. chocolata provenientes de Bahia Caldera sufre de imposex. El analisis macroscopico revelo atrofia de la vagina y de las glandulas femeninas. Algunas hembras carecen de glandula ingestiva y receptaculo seminal. Se determino alteraciones citologicas como la modificacion del epitelio interno, ocurrencia de areas acelulares, falta de lamina basal y presencia de nucleo picnotico, y superposicion de tejido prostatico en las tres glandulas femeninas. Las alteraciones anatomicas e histologicas asociadas al imposex determinan la esterilidad absoluta de las hembras. El sindrome alcanzo los grados maximos en todas las escalas aplicadas, excepto en la de Barreiro et al. (2001). Se recomienda el uso del VDSI para T. chocolata, ya que, es una medida realista de la virilizacion y potencial reproductivo de las hembras y no estaria afectado por la forma y tamano del pene.
Published: 2016

142. Persistent Negative Symptoms in First-Episode Psychosis: Early Cognitive and Social Functioning Correlates and Differences Between Early and Adult Onset

Author: Iluminada Corripio, Ramón Landin-Romero, ANGELA IBAÑEZ, Miquel Bioque, Vicent Balanzá-Martínez, Anna Alonso, Ana María González-Pinto, Gisela Mezquida, Salvador Sarró, Jose Menchon, Elena De la Serna, Silvia Amoretti, Mara Parellada, Anabel Martinez-Aran, BIBIANA CABRERA, Marina Garriga, Manuel J. Cuesta, Paz Garcia-Portilla, Julio Bobes, Miquel Bernardo, Soledad Romero, and Eduard Vieta
Subjects: Adult, Male, Psychosis, medicine.medical_specialty, Longitudinal study, Adolescent, Neuropsychological Tests, 03 medical and health sciences, Young Adult, 0302 clinical medicine, medicine, Humans, Cognitive Dysfunction, Longitudinal Studies, Young adult, Age of Onset, Psychiatry, Child, Psychiatric Status Rating Scales, Positive and Negative Syndrome Scale, business.industry, Age Factors, Cognition, medicine.disease, Executive functions, 030227 psychiatry, Psychiatry and Mental health, Psychotic Disorders, Case-Control Studies, Female, Age of onset, business, Social Adjustment, 030217 neurology & neurosurgery, Clinical psychology, Executive dysfunction
Abstract: OBJECTIVE To characterize the early cognitive and social functioning characteristics of a sample of first-episode psychosis patients with and without persistent negative symptoms (PNS) and to examine the prevalence and cognitive and functional correlates of PNS in patients with early-onset versus adult-onset first-episode psychosis. METHODS Participants were 235 patients with first-episode psychosis (51 early-onset, 184 adult-onset) and 240 healthy controls from a multicenter longitudinal study (recruited between 2009 and 2011). Standard instruments were used to evaluate symptoms, cognition, and social functioning. Diagnoses were determined according to DSM-IV criteria. PNS proxy was derived from clinical assessments (Positive and Negative Syndrome Scale and Montgomery-Asberg Depression Scale) at 2-, 6-, and 12-month follow-up. Association tests were used to compare the prevalence of PNS in the early-onset versus adult-onset groups. Multivariate analysis of variance was used to examine differences in early cognitive and social functioning (at the 2-month assessment) between patients with and without PNS and between early-onset and adult-onset patients with PNS. RESULTS Thirty-eight patients (16.2%) met criteria for PNS during the first year. This PNS group showed a selective deficit in executive functions and in global, community, and occupational functioning (P < .05). Having PNS was associated with a diagnosis of a schizophrenia spectrum disorder at the 12-month follow-up. The prevalence of PNS was almost double for those patients with an early-onset (0.25 vs 0.14; OR = 2.18; 95% CI, 1.02-4.64), and this was associated with greater cognitive (P < .05) but not social deficits. CONCLUSIONS There was an early, detectable, social and executive dysfunction associated with PNS in first-episode psychosis and a high risk of having PNS in early-onset first-episode psychosis, which in turn was associated with more widespread cognitive impairment. Specific therapeutic interventions for PNS in early-onset first-episode psychosis might be needed.
Published: 2016

143. A developmental approach to dimensional expression of psychopathology in child and adolescent offspring of parents with bipolar disorder

Author: Dolores Moreno, Celso Arango, Gisela Sugranyes, Ana Espliego, Elisa Rodríguez-Toscano, Covadonga M. Díaz-Caneja, Soledad Romero, María Goretti Morón-Nozaleda, Vanessa Sánchez-Gistau, Immaculada Baeza, Carmen Moreno, Josefina Castro-Fornieles, and Elena de la Serna
Subjects: Male, Parents, medicine.medical_specialty, Bipolar Disorder, Adolescent, Offspring, Developmental Disabilities, 03 medical and health sciences, 0302 clinical medicine, Child of Impaired Parents, Developmental and Educational Psychology, Child and adolescent psychiatry, medicine, Prevalence, Humans, Bipolar disorder, Psychiatry, Child, Psychopathology, Confounding, General Medicine, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Mood disorders, Pediatrics, Perinatology and Child Health, Female, Psychology, Psychosocial, 030217 neurology & neurosurgery, Developmental psychopathology, Clinical psychology
Abstract: The aim of this is to describe psychopathology, functioning and symptom dimensions accounting for subthreshold manifestations and developmental status in child and adolescent offspring of parents with bipolar disorder (“high-risk offspring”). The study population comprised 90 high-risk offspring (HR-offspring) and 107 offspring of community control parents (CC-offspring). Direct clinical observations and parental and offspring reports based on selected standardized clinical scales were used to assess offspring threshold and subthreshold diagnoses, symptoms and functioning. All outcomes were compared between the whole HR-offspring and CC-offspring samples and then by developmental status. After controlling for potential confounders, HR-offspring showed significantly poorer adjustment for childhood (r = 0.18, p = 0.014) and adolescence (r = 0.21, p = 0.048) than CC-offspring, as well as more emotional problems (r = 0.24, p = 0.001) and higher depression scores (r = 0.16, p = 0.021). As for differences in lifetime categorical diagnoses (threshold and subthreshold) between HR-offspring and CC-offspring, the prevalence of disruptive disorders was higher in pre-pubertal HR-offspring (OR 12.78 [1.45–112.42]), while prevalence of mood disorders was higher in post-pubertal HR-offspring (OR 3.39 [1.14–10.06]). Post-pubertal HR-offspring presented more prodromal (r = 0.40, p = 0.001), negative (r = 0.38, p = 0.002), manic (r = 0.22, p = 0.035) and depressive (r = 0.23, p = 0.015) symptoms than pre-pubertal HR-offspring, as well as more peer relationship problems (r = 0.31, p = 0.004), poorer childhood adjustment (r = 0.22, p = 0.044) and worse current psychosocial functioning (r = 0.27, p = 0.04). Externalizing psychopathology is more prevalent in pre-pubertal HR-offspring, while depressive and prodromal symptoms leading to functional impairment are more prominent in post-pubertal HR-offspring. Developmental approaches and dimensional measures may be useful for identifying children at high risk of developing bipolar disorder and help guide specific preventive strategies.
Published: 2016

144. Chromosomal translocation engineering to recapitulate primary events of human cancer

Author: Rosalind Codrington, Terence H. Rabbitts, Richard Pannell, N. Chan, T. Tanaka, Alan Forster, Soledad Romero Rodríguez, Florencia Cano, C.-H. Nam, Angelika Daser, N. Lobato, Markus Metzler, and Lesley F Drynan
Subjects: Chromosome engineering, Chromosomal translocation, Biology, Biochemistry, Translocation, Genetic, Fusion gene, Mice, Neoplasms, Genetics, medicine, Animals, Chromosomes, Human, Humans, Molecular Biology, Gene, Chromosomal inversion, Recombination, Genetic, Models, Genetic, Intron, Cancer, medicine.disease, Mice, Mutant Strains, Disease Models, Animal, Chromosome Inversion, Genetic Engineering, Homologous recombination
Abstract: Mouse models of human cancers are important for understanding determinants of overt disease and for "preclinical" development of rational therapeutic strategies; for instance, based on macrodrugs. Chromosomal translocations underlie many human leukemias, sarcomas, and epithelial tumors. We have developed three technologies based on homologous recombination in mouse ES cells to mimic human chromosome translocations. The first, called the knockin method, allows creation of fusion genes like those typical of translocations of human leukemias and sarcomas. Two new conditional chromosomal translocation mimics have been developed. The first is a method for generating reciprocal chromosomal translocations de novo using Cre-loxP recombination (translocator mice). In some cases, there is incompatible gene orientation and the translocator model cannot be applied. We have developed a different model (invertor mice) for these situations. This method consists of introducing an inverted cDNA cassette into the intron of a target gene and bringing the cassette into the correct transcriptional orientation by Cre-loxP recombination. We describe experiments using the translocator model to generate MLL-mediated neoplasias and the invertor method to generate EWS-ERG-mediated cancer. These methods mimic the situation found in human chromosome translocations and provide the framework for design and study of human chromosomal translocations in mice.
Published: 2016

145. Neuropsychological characteristics of child and adolescent offspring of patients with schizophrenia or bipolar disorder

Author: Mª José Penzol, Elena de la Serna, Montserrat Vila, Josefina Castro-Fornieles, Vanessa Sánchez-Gistau, Immaculada Baeza, Teresa Sánchez-Gutiérrez, Gisela Sugranyes, Dolores Moreno, Elisa Rodríguez-Toscano, and Soledad Romero
Subjects: Male, medicine.medical_specialty, Bipolar Disorder, Adolescent, Neuropsychological Tests, Verbal learning, 03 medical and health sciences, Executive Function, 0302 clinical medicine, Visual memory, Child of Impaired Parents, Intellectual Disability, medicine, Humans, Attention, Bipolar disorder, Psychiatry, Child, Biological Psychiatry, Psychiatric Status Rating Scales, Working memory, Cognition, Executive functions, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Schizophrenia, Female, Schizophrenic Psychology, Verbal memory, Psychology, Cognition Disorders, 030217 neurology & neurosurgery
Abstract: Background Schizophrenia (SZ) and bipolar disorder (BD) are considered neurobiological disorders which share some clinical, cognitive and neuroimaging characteristics. Studying child and adolescent offspring of patients diagnosed with bipolar disorder (BDoff) or schizophrenia (SZoff) is regarded as a reliable method for investigating early alterations and vulnerability factors for these disorders. This study compares the neuropsychological characteristics of SZoff, BDoff and a community control offspring group (CC) with the aim of examining shared and differential cognitive characteristics among groups. Methods 41 SZoff, 90 BDoff and 107 CC were recruited. They were all assessed with a complete neuropsychological battery which included intelligence quotient, working memory (WM), processing speed, verbal memory and learning, visual memory, executive functions and sustained attention. Results SZoff and BDoff showed worse performance in some cognitive areas compared with CC. Some of these difficulties (visual memory) were common to both offspring groups, whereas others, such as verbal learning and WM in SZoff or PSI in BDoff, were group-specific. Conclusions The cognitive difficulties in visual memory shown by both the SZoff and BDoff groups might point to a common endophenotype in the two disorders. Difficulties in other cognitive functions would be specific depending on the family diagnosis.
Published: 2016

146. Abundance and spatial distribution of neustonic copepodits of Microsetella rosea (Harpacticoida: Ectinosomatidae) along the western Magellan coast, southern Chile

Author: Juan I. Cañete, Carlos Olave, Carlos S. Gallardo, Tania Figueroa, María Soledad Romero, and Daniela Haro
Subjects: 0106 biological sciences, southern Chile, 010504 meteorology & atmospheric sciences, Ectinosomatidae, neuston, Aquatic Science, Oceanography, 01 natural sciences, Copepoda, Abundance (ecology), subantarctic zooplankton, Harpacticoida, 0105 earth and related environmental sciences, geography, geography.geographical_feature_category, biology, oximax zone, 010604 marine biology & hydrobiology, Estuary, Pelagic zone, biology.organism_classification, estuaries, Environmental science, Microsetella rosea, Neuston, Bay, Copepod
Abstract: The pelagic harpacticoid copepod Microsetella rosea inhabits the cold waters along the temperate southern coast of Chile, where its population biology and ecological role in the neuston are unknown. During a CIMAR 16 Fiordos cruise realized in the Magellan Region, 26 neustonic samples were collected to analyze the abundance, spatial distribution of copepodits and oceanographic conditions (temperature, salinity, and dissolved oxygen). M. rosea copepodits, the most abundant holoneustonic taxa (30% of total abundance), were present at all sampled stations and were 0.5 times more abundant than calanoids. These copepodits inhabited waters ranging between 6.5-8.5°C and salinity of 26-33, with maximum abundances (1,000-10,000 ind/5 min horizontal drag) at means of 7.2 ± 0.6ºC and salinities of 30.7 ± 0.9. Froward Cape, Almirantazgo Sound, and Inútil Bay stations accounted for 65% of total M. rosea abundance, whereas Beagle Channel stations present the lowest abundances (
Published: 2016

147. Fernández Cortada, Ruth Noemí

Author: María Soledad Romero
Published: 2016

148. Hernández, Juano

Author: María Soledad Romero
Published: 2016

149. Cortical Morphology Characteristics of Young Offspring of Patients With Schizophrenia or Bipolar Disorder

Author: Josefina Castro-Fornieles, Roger Borràs, Clemente Garcia-Rizo, Elena de la Serna, Vanessa Sánchez-Gistau, Jose Manuel Goikolea, Soledad Romero, Cristina Solé-Padullés, Gisela Sugranyes, Dolores Moreno, Inmaculada Baeza, and Núria Bargalló
Subjects: Adult, Male, medicine.medical_specialty, Bipolar Disorder, Adolescent, Offspring, Cortical morphology, Prodromal Symptoms, 03 medical and health sciences, 0302 clinical medicine, Neuroimaging, Child of Impaired Parents, Internal medicine, Developmental and Educational Psychology, medicine, Humans, Cortical surface, Bipolar disorder, Genetic risk, Child, Cerebral Cortex, Middle Aged, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Endocrinology, Cross-Sectional Studies, Schizophrenia, Female, Occipital lobe, Psychology, Neuroscience, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract: Objective Cortical surface area and thickness abnormalities have been observed in patients with schizophrenia and bipolar disorders; however, no study thus far has examined cortical morphologic measurements in children and adolescents at genetic risk for the disorders comparatively. Method One hundred thirty-seven participants, including 36 offspring of patients with schizophrenia (SzO), 54 offspring of patients with bipolar disorder (BpO), and 47 offspring of community controls (CcO), 6 to 17 years old, were assessed with clinical and neuroimaging methods. Sixty-nine percent of the sample was reassessed at a 27.6-month (mean) follow-up. Cortical surface reconstruction was applied to measure cortical area and thickness using FreeSurfer; mixed-effects models were used to investigate cross-sectional and longitudinal differences in global and lobar morphologic measurements. Results The SzO group exhibited a cross-sectional decrease in global, parietal, and occipital lobe surface area compared with the CcO group, and in the occipital lobe compared with the BpO group. In the SzO group, global and parietal surface area values were inversely associated with attenuated positive and negative prodromal symptom scores. No cross-sectional differences in cortical thickness were observed. Division of the sample by pubertal status showed group-by-time interactions in the pubertal and postpubertal SzO subgroup, with less longitudinal decrease in cortical surface area and thickness than in the CcO and BpO subgroups, respectively. Conclusion The SzO, but not the BpO, group was characterized by cross-sectional decreases in surface area, and this was associated with prodromal symptoms. Longitudinal changes in cortical morphology associated with risk for schizophrenia may be expressed differently according to developmental stage.
Published: 2016

150. Cognitive characterization of offspring of patients with schizophrenia, bipolar disorder and a community control with ADHD traits

Author: Immaculada Baeza, Josefina Castro-Fornieles, G. Morón, Soledad Romero, Elisa Rodríguez-Toscano, A. Sarabia, G. Sugranyes, Vanessa Sánchez-Gistau, Covadonga M. Díaz-Caneja, E. De la Serna, K. Martínez, Dolores Moreno, and Carmen Moreno
Subjects: Pharmacology, medicine.medical_specialty, Offspring, Community control, Cognition, medicine.disease, Psychiatry and Mental health, Neurology, Schizophrenia, medicine, Pharmacology (medical), Neurology (clinical), Bipolar disorder, Psychiatry, Psychology, Biological Psychiatry, Clinical psychology
Published: 2017

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