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Vaccine effectiveness (VE) studies provide real-world evidence to monitor vaccine performance and inform policy. The WHO Regional Office for the Eastern Mediterranean supported a regional study to assess the VE of COVID-19 vaccines against different clinical outcomes in four countries between June 2021 and August 2023. Health worker cohort studies were conducted in 2707 health workers in Egypt and Pakistan, of whom 171 experienced symptomatic laboratory-confirmed SARS-CoV-2 infection. Test-negative design case–control studies were conducted in Iran and Jordan in 4017 severe acute respiratory infection (SARI) patients (2347 controls and 1670 cases) during the Omicron variant dominant period. VE estimates were calculated for each study and pooled by study design for several vaccine types (BBIBP-CorV, AZD1222, BNT162b2, and mRNA-1273, among others). Among health workers, VE against symptomatic infection of a complete primary series could only be computed compared to partial vaccination, suggesting a benefit of providing an additional dose of mRNA vaccines (VE: 88.9%, 95%CI: 15.3–98.6%), while results were inconclusive for other vaccine products. Among SARI patients, VE against hospitalization of a complete primary series with any vaccine compared to non-vaccinated was 20.9% (95%CI: 4.5–34.5%). Effectiveness estimates for individual vaccines, booster doses, and secondary outcomes (intensive care unit admission and death) were inconclusive. Future VE studies will need to address challenges in both design and analysis when conducted late during a pandemic and will be able to utilize the strengthened capacities in countries.

Knowledge management is critical for universities and research institutes to improve their operations and activities. The study aimed to investigate knowledge management components in Iran University of Medical Sciences research centers from the faculty members' perspective. The sample size for the present study was generated using a simple random approach and Cochran's formula. The sample size was 245 out of 673 associate faculty members in affiliated research centers of the Iran University of Medical Sciences. The research instrument was the Fong and Choi knowledge management standard questionnaire. Following data collection, SPSS software version 23 was used to analyze the data using descriptive statistics and Pearson correlation tests. From the participant's perspective, the results indicated that the status of knowledge acquisition components was relatively good, with an average of 3.26, knowledge creation at 3.42, knowledge storage at 3.19, knowledge distribution at 3.13, knowledge application at 3.34, and knowledge retention at 3.24. According to respondents, there was an inverse statistical relationship between knowledge generation and application components and the research ranking of research centers and a direct statistical relationship between knowledge storage and retention (P-value < 0.05). There was no correlation between knowledge acquisition and distribution and the research ranking of the centers (P-value > 0.05). According to the findings, knowledge management components were applied effectively in research institutions affiliated with the Iran University of Medical Sciences. As a result, planning and strategies at research institutions and universities are required to raise this level to the desired level.

Objective: Efficient production of functional and mature alveolar epithelial is a major challenge for developing any cellreplacement therapy for lung degenerative diseases. The extracellular matrix (ECM) pro-vides a dynamic environmentand mediates cellular responses during development and maintenance of tissue functions. The decellularized ECM(dECM) which retains its native-like structure and bio-chemical composition can provide the induction of embryonicstem cell (ESC) differentiation toward the tissue-specific lineages during in vitro culture. Therefore, the aim of this studywas to evaluate the effect of sheep lung dECM-derived scaffold on differentiation and further maturation of ESC-derivedlung progenitor cells.Materials and Methods: This study was an experimental study. In the first step, a sheep lung was decellularizedto achieve dECM scaffolds and hydrogels. Afterwards, the obtained dECM scaffold was evaluated for collagen andglycosaminoglycan contents, DNA quantification, and its ultrastructure. Next, the three experimental groups: i. Sheeplung dECM-derived scaffold, ii. Sheep lung dECM-derived hydrogel, and iii. Fibronectin-coated plates were comparedin their abilities to induce further differentiation of human embryonic stem cells (hESCs)-derived definitive endoderm(DE) into lung progenitor cells. The comparison was evaluated by immuno-staining and real-time polymerase chainreaction (PCR) assessments.Results: We found that the dECM-derived scaffold preserved its composition and native porous structures whilelacking nuclei and intact cells. All experimental groups displayed lung progenitor cell differen-tiation as revealed by theRNA and protein expression of NKX2.1, P63 and CK5. DE cells differenti-ated on dECM-derived scaffold and dECMderivedhydrogel showed significant upregulation of SOX9 gene expression, a marker of the distal airway epithelium.DE cells differentiated on the dECM-derived scaffold compared to the two other groups, showed enhanced expressionof SFTPC (type 2 alveolar epithelial [AT2] cell marker), FOXJ1 (ciliated cell marker), and MUC5A (secretory cell marker)genes.Conclusion: Overall, our results suggest that dECM-derived scaffold improves the differentiation of DE cells towardslung alveolar progenitor cells in comparison with dECM-derived hydrogel and fibronectin-coated plates.

Purpose. The aim of this umbrella review was to identify the main information needs of breast cancer survivors. Since several reviews have already been done on this topic, conducting an umbrella review not only combines their results but also gives a comprehensive picture and informative summary of breast cancer survivors’ needs. Method. The search was performed in PubMed, Embase, Scopus, Web of Science, ProQuest, Cochrane, and Google Scholar from inception to the end of March 2024. This review was conducted according to the JBI methodology for umbrella reviews, and the report was based on Rutten’s category for information needs of patients with cancer. After removing duplicate and irrelevant articles, 14 systematic reviews were included in the analysis. The JBI checklist was used for evaluating the quality of eligible articles. Results. The information needs were classified into 11 main categories and 86 subcategories. As a result of this umbrella review, one category was added to Rutten’s 10 categories. Also, treatment information needs were introduced as the main identified category. Information on supportive care needs ranked second, and body image/sexuality information needs ranked third with a slight difference. Conclusion. The information needs outlined in the present study can serve as a general model to help clinical decision makers and policymakers in order to better understand the needs of the group and meet the information needs of the population. Implications for Cancer Survivors. These recommendations can promote and develop targeted interventions to reduce the psychosocial consequences of breast cancer survivors and increase their quality of life.

Abstract Background Methylmalonic acidemia (MMA) is a rare metabolic disorder resulting from functional defects in methylmalonyl-CoA mutase. Mutations in the MMAB gene are responsible for the cblB type of vitamin B12-responsive MMA. Results This study used Whole-exome sequencing (WES), Sanger sequencing, linkage analysis, and in-silico evaluation of the variants’ effect on protein structure and function to confirm their pathogenicity in a 2-day-old neonate presenting an early-onset metabolic crisis and death. WES revealed a homozygous missense variant on chromosome 12, the NM_052845.4 (MMAB):c.557G > A, p.Arg186Gln, in exon 7, a highly conserved and hot spot region for pathogenic variants. After being confirmed by Sanger sequencing, the wild-type and mutant proteins’ structure and function were modeled and examined using in-silico bioinformatics tools and compared to the variant NM_052845.4 (MMAB):c.556C > T, p.Arg186Trp, a known pathogenic variant at the same position. Comprehensive bioinformatics analysis showed a significant reduction in the stability of variants and changes in protein–protein and ligand–protein interactions. Interestingly, the variant c.557G > A, p.Arg186Gln depicted more variations in the secondary structure and less binding to the ATP and B12 ligands compared to the c.556C > T, p.Arg186Trp, the known pathogenic variant. Conclusion This study succeeded in expanding the variant spectra of the MMAB, forasmuch as the variant c.557G > A, p.Arg186Gln is suggested as a pathogenic variant and the cause of severe MMA and neonatal death. These results benefit the prenatal diagnosis of MMA in the subsequent pregnancies and carrier screening of the family members. Furthermore, as an auxiliary technique, homology modeling and protein structure and function evaluations could provide geneticists with a more accurate interpretation of variants’ pathogenicity. Graphical Abstract

Abstract Lymph node metastasis is the most important prognostic factor in patients with lung squamous cell carcinoma. The current findings show that lymph node metastatic tumor cells can arise by programming metastasis in primary tumor cells. Thereby, the genetic alterations responsible for the metastasis could be detected in the primary tumors. This bioinformatic study aimed to determine novel potential prognostic biomarkers shared between primary lung squamous cell tumors (without lymph node metastasis) and lymphatic metastasis, using the Cancer Genome Atlas database. Differentially expressed genes were screened by limma statistical package in R environment. Gene ontology and biological pathways analyses were performed using Enrichr for up-regulated and down-regulated genes. Also, we selected lymph node metastasis related genes among DEGs using correlation analysis between DEGs and suitable references genes for metastasis. Receiver operating characteristic curves was applied using pROC and R package ggplot2 to evaluate diagnostic value of differentially expressed genes. In addition, survival and drug resistance analyses were performed for differentially expressed genes. The miRNA-mRNA interaction networks were predicted by miRwalk and TargetScan databases and expression levels analysis of the miRNAs which were mainly targeting mRNAs was performed using UALCAN database. Protein–protein interaction network analysis and hub genes identification were performed using FunRich and Cytoscape plugin cytoHubba. In this study, a total of 397 genes were differentially expressed not only with a significant difference between N + vs. normal and N0 vs. normal but also with significant difference between N + vs. N0. Identified GO terms and biological pathways were consistent with DEGs role in the lung squamous cell carcinoma and lymph node metastasis. A significant correlation between 56 genes out of 397 differentially expressed genes with reference genes prompted them being considered for identifying lymph node metastasis of lung squamous cell carcinoma. In addition, SLC46A2, ZNF367, AC107214.1 and NCBP1 genes were identified as survival-related genes of patients with lung squamous cell carcinoma. Moreover, NEDD9, MRPL21, SNRPF, and SCLT1 genes were identified to be involved in lung squamous cell carcinoma drug sensitivity/resistance. We have identified several numbers of miRNAs and their related target genes which could emerge as potential diagnostic biomarkers. Finally, CDK1, PLK1, PCNA, ZWINT and NDC80 identified as hub genes for underlying molecular mechanisms of lung squamous cell carcinoma and lymphatic metastasis. Our study highlights new target genes according to their relation to lymph node metastasis, whose expressions in the primary lung squamous cell carcinoma are able to accurately assess the presence of lymphatic metastasis.

Abstract In the present study, new structural variants of 4-hydroxyquinolinone-hydrazones were designed and synthesized. The structure elucidation of the synthetic derivatives 6a–o was carried out using different spectroscopic techniques including FTIR, 1H-NMR, 13C-NMR, and elemental analysis, and their α-glucosidase inhibitory activity was also determined. The synthetic molecules 6a–o exhibited good α-glucosidase inhibition with IC50 values ranging between 93.5 ± 0.6 to 575.6 ± 0.4 µM as compared to the standard acarbose (IC50 = 752.0 ± 2.0 µM). Structure–activity relationships of this series were established which is mainly based on the position and nature of the substituent on the benzylidene ring. A kinetic study of the active compounds 6l and 6m as the most potent derivatives were also carried out to confirm the mode of inhibition. The binding interactions of the most active compounds within the active site of the enzyme were determined by molecular docking and molecular dynamic simulations.

Objective: Depressive disorders are common among those with bipolar disorder II (BD II) and may necessitate the use of antidepressants. Because of the lack of quality evidence, there is controversy about the use of antidepressants in BD II. The aim was to compare the efficacy of venlafaxine and bupropion in the treatment of depressive episode in BD II. Materials and Methods: This randomized triple-blind clinical trial study was conducted on patient with depressive episode of BD II (based on diagnostic and statistical manual of disorders [DSM-V] criteria) referred to the specialized clinic of Golestan Hospital. A total of 40 patients were randomly divided into two groups of receiving venlafaxine (75 mg/day) or bupropion (100 mg/day) for 4 weeks. At the end of the intervention, the effectiveness of treatment was assessed using the Hamilton Depression Rating Scale (HDRS). Results: The results of this study showed that the HDRS score before treatment (P = 0.43) and after treatment (P = 0.15) was not significantly different between the two groups. HDRS score in both groups significantly decreased after 4 weeks (P < 0.0001). Although the rate of decrease in depression score was more in venlafaxine than in bupropion, these differences were not significant (% 36.7 ± 21.8 vs. % 45.3 ± 17.9, P value = 0.17). Conclusion: Our study showed that short-term (4-weeks) treatments of venlafaxine and bupropion were equally effective and could be a safe and effective antidepressant monotherapy for BD II major depression. It is suggested that more studies be conducted with larger sample size and over longer periods of time in a multicenter manner.

Due to the importance of environmental effects of manufacturing system in recent decades, the production systems are obliged to comply different environmental regulations. The present research, aims to design a green supply chain model for Guilan steel industry with a hybrid approach. This study is applied research in term of purpose, exploratory in term of method, quantitative and qualitative in terms of data type. A researcher made questionnaire are applied, in addition to interview, for data gathering. The under-study research population includes steel industry experts out of them, 12 experts were selected for data gathering phase. Conducting the research, first applying fuzzy Delphi method, 5 main factors and 25 important sub-factors were identified. Then, using fuzzy DEMATEL and interpretive structural modeling (ISM) methods, the importance of each facto was determined, in which two factors "external environment study" and "internal environment study" were at the highest level of the importance, while "Waste reduction", "waste recycling" and "purchasing based on environmental products" were at the last level. These variables are interrelated and affect their next levels.

Abstract: Articles 454 and 455 of the Civil Code are ambiguous in terms of the examples of the "right of rescission", the examples of "the implied condition of prohibition of the customer in the assignment" and the meaning of the word "void"; however, the supreme court decision as a unified judicial precedent No. 810 dated 24/06/2021is also vague and outside the scope of the lawsuits. A court has described the option of violation of the payment of installments and the delivery of the goods upon rescission as an implicit prohibition of the customer's assignment, and has ruled on the invalidity of the possessions and eviction. But in similar lawsuits, another court, from the terms of the same contract, did not describe such a concept, and with a different interpretation of the law, ruled against the seller. The supreme court emphasized the intent of the contracting parties in the case of the right to rescind the contract and return of goods sold, by commenting on an implicit matter, and did not comment on the legal status of the possession of the seller, and believes that the owner's right of priority does not invalidate the condition and the right of rescission against the return of the goods. While, according to the opinion of the majority of late and contemporary jurisprudents, deduced from Articles 454 and 455 of the Civil Code, the customer's right of assignment in the contractual right of rescission is dependent null. Thus, since the implicit matter of the return of goods sold and the request for eviction is based on the request for the cancellation of the assignment, the decision of the court is logically voidable.

Introduction: Strongyloides stercoralis a globally widespread human intestinal nematode. Hyperinfection mainly appears in patients with defective immune systems . This study intended to investigate the prevalence of serum positive Strongyloides stercoralis in cancer patients who have never undergone chemotherapy and those who received at least one cycle of chemotherapy. Materials and Methods: This study targeted cancer patients, referred to Rasht hospital, and assigned them to two groups of cancer patients with no history of chemotherapy and cancer patients with at least one cycle of chemotherapy. Patient’s demographic information, underlying diseases and chemotherapy regimen were recorded, and their serum sample was examined. Results: 410 patients were included in this study. the majority were female ( 51/7% ). About 40 patients tested positive for serology, out of which 14 were in the chemotherapy-treated group and 26 in chemotherapy-untreated group, indicating that the prevalence of serum positive Strongyloides stercoralis was significantly higher in patients with no history of chemotherapy. Moreover, eosinophilia significantly correlated with the prevalence of seropositivity. The chemotherapy protocol containing high doses of corticosteroids could multiply the risk of positive serology by 12.7 times. Conclusion: Before chemotherapy, in areas with a higher prevalence of Strongyloides stercoralis, especially in high corticosteroids protocols, it may make sense to study Strongyloides stercoralis . It becomes more vital in men and eosinophilic patients. Since serologic testing may display false negative rates in patients with defective immune systems, subsequently, alternative complementary methods such as fecal larval examination and fecal PCR test are highly suggested to be carried out along with serology.

Abstract Conventional Wilkinson power dividers (WPDs) can provide acceptable performance close to the nominal center frequency. However, these WPDs can also exhibit poor out-of-band performance while requiring a large footprint. In order to improve on the current state of the art, a modified microstrip WPD is proposed that exhibits a substantially improved stopband and high isolation. A lowpass filter (LPF) structure is utilized in both branches of the power divider to provide harmonic suppression. According to the obtained results, the input return loss (|S 11|), output return loss (|S 22|), output insertion loss (|S 21|) and isolation (|S 32|) are better than 34.2 dB, 26.2 dB, 3.52 dB and 31.2 dB, respectively. The proposed modified WPD has a wide 20 dB stopband (from 2.54 GHz to 13.48 GHz) and filters the second to seventh harmonics with attenuation levels of greater than 20 dB. The proposed WPD has a small size of 33.8 mm × 27 mm (0.42 λg × 0.33 λg), where λg is the guided wavelength at the operating frequency of 1.8 GHz. The WPD has been fabricated and tested and shows good agreement between simulated and measured results and the proposed design has desirable characteristics for LTE and GSM applications.

Knowledge sharing is a competitive advantage and necessity for the success of any organization. Meanwhile, knowledge networks have been introduced as a way to enhance knowledge sharing between individuals and as an effective tool to facilitate knowledge exchange in clinical, educational, and commercial fields. The purpose of this paper is to identify the factors that can affect the level of knowledge sharing and exchange between academic and scientific specialists in knowledge networks and Communities of Practice (COP). A systematic literature review was conducted using the PRISMA guidelines. Four databases were searched, including Scopus, Web of Science, PubMed, and ProQuest. Google Scholar search was conducted to complete the search and ensure the tracking of the gray literature. Also, relevant sources, references, and reference lists of the related articles were reviewed. The studies were searched from April until August 2022 and finally the content analysis of the findings was done. Two reviewers independently assessed the quality of included studies. Data were extracted using the Joanna Briggs Institute (JBI) checklist tool. Of the 1439 records, 13 studies met the inclusion criteria. This study identified three main categories of factors affecting knowledge sharing in knowledge networks and COPs as individual factors, organizational, and structural. The results showed that knowledge networks provide opportunities to overcome professional barriers and complex systemic challenges and lead to knowledge sharing and exchange among scientific specialists. This article has important implications for managers, health policymakers, and academics who wish to expand knowledge sharing of scientific specialists through knowledge networks and CoPs in knowledge-based organizations.

Background: Neck pain is a common cause of disability across the world. The objective of the present study was to present a thorough investigation of the burden caused by neck pain in the Middle East and North Africa (MENA) region, by country, sex, age group and socio-demographic index (SDI). Methods: The data on the burden of neck pain, encompassing its prevalence, incidence and years lived with disability (YLDs), were extracted from the Global Burden of Disease (GBD) 2019 study. These findings are reported as age-standardised numbers and rates (per 100,000), accompanied by 95 % uncertainty intervals (UIs). Results: The age-standardised point prevalence of neck pain in 2019 was 3066.7 (95 % UI: 2407.8 to 3894.3) per 100,000, with an age-standardised incidence rate of 649.2 (509.2–829.2) in the MENA region, neither of which have changed since 1990. The age-standardised YLD rate of neck pain was 303.0 (201.5–438.8) per 100,000 population in 2019. The highest YLD rate of neck pain was found in Iran [423.5 (280.3–609.8)] and the lowest in Kuwait [215.0 (141.0–314.1)]. The highest number of prevalent cases were seen in the 45–49 age-group for both sexes in 2019, but overall females had a higher point prevalence than males. Furthermore, over the study period (1990–2019) there was no clear and consistent relationship between the SDI and the burden of neck pain. Conclusion: Although the burden of neck pain has largely remained stable over the past three decades, the prevalence and morbidity in the MENA region remains high. Preventive and rehabilitative programs should be implemented that firstly target middle-aged females and males.

Objective: The application of structural equation modeling (SEM), a statistical modeling tool for scale construction and development, is becoming increasingly popular in the health sciences librarianship and information science research. This study explores the application of SEM to health science libraries by describing the development and validation of a modified LibQUAL scale within an Iranian health sciences library setting. Methods: A literature search was performed across several information sources to identify candidate items to be included in the primary questionnaire. After translation, linguistic validation, and a pilot study, two cross-sectional studies were performed. SEM modeling framework was used for the assessment of the reliability and validity of the modified LibQUAL scale. The internal consistency of the scale was evaluated by measuring Cronbach’s alpha coefficient and composite reliability. Exploratory and confirmatory factor analyses were used for the evaluation of the construct validity of the scale. Smart-PLS software was used for statistical modeling. Results: Composite reliability and Cronbach’s alpha coefficient for each scale ranged between 0.90 and 0.95, indicating adequate internal consistency with the LibQUAL scale. Confirmatory factor analysis confirmed the three-factor model of the LibQUAL scale. The convergent validity of the scale was supported, as the average variances extracted for all proposed factors were above 0.50. The discriminant validity was also confirmed using Fornel and Larcker and Heterotrait–Monotrait Ratio (HTMT) methods. Conclusion: Evaluation of psychometric properties of the translated and locally modified LibQUAL in the Persian language indicated adequate reliability, factorial validity, and stability of this instrument for Iranian health sciences libraries.

Abstract Background Early age at menarche and tall stature are associated with increased breast cancer risk. We examined whether these associations were also positively associated with mammographic density, a strong marker of breast cancer risk. Methods Participants were 10,681 breast-cancer-free women from 22 countries in the International Consortium of Mammographic Density, each with centrally assessed mammographic density and a common set of epidemiologic data. Study periods for the 27 studies ranged from 1987 to 2014. Multi-level linear regression models estimated changes in square-root per cent density (√PD) and dense area (√DA) associated with age at menarche and adult height in pooled analyses and population-specific meta-analyses. Models were adjusted for age at mammogram, body mass index, menopausal status, hormone therapy use, mammography view and type, mammographic density assessor, parity and height/age at menarche. Results In pooled analyses, later age at menarche was associated with higher per cent density (β √PD = 0.023 SE = 0.008, P = 0.003) and larger dense area (β √DA = 0.032 SE = 0.010, P = 0.002). Taller women had larger dense area (β √DA = 0.069 SE = 0.028, P = 0.012) and higher per cent density (β √PD = 0.044, SE = 0.023, P = 0.054), although the observed effect on per cent density depended upon the adjustment used for body size. Similar overall effect estimates were observed in meta-analyses across population groups. Conclusions In one of the largest international studies to date, later age at menarche was positively associated with mammographic density. This is in contrast to its association with breast cancer risk, providing little evidence of mediation. Increased height was also positively associated with mammographic density, particularly dense area. These results suggest a complex relationship between growth and development, mammographic density and breast cancer risk. Future studies should evaluate the potential mediation of the breast cancer effects of taller stature through absolute breast density.

Background: Vaccines have played a special role in controlling and reducing mortality from infectious diseases. In this regard, DNA vaccines were developed to ease the production and reduce the risks of traditional vaccines. Human papillomavirus (HPV) has been introduced as the causing agent of cervical cancer. The capsid protein (L1) of HPV has been used to produce subunit and DNA vaccines. The aim of this experimental research is to design and construct the L1 expression system of HPV 18 and to investigate its expression in eukaryotic cells. Method and Materials: In this experimental study, the L1 gene of HPV 18 was subcloned in the expression vector pcDNA 3.1 Hygro after optimization and synthesis. Cloning was confirmed through colony PCR test and enzyme digestion reaction. The expression vector was transfected into HEK293 cells using the Turbofect reagent. After 72 hours, total RNA was extracted from transfected cells and control cells and cDNA was synthesized. Gene expression was examined at the mRNA level in cells by performing PCR on cDNA. Results: The results showed that following the optimization of the L1 gene sequence, the CAI and Fop indices increased to an ideal level. The cloning of the optimized HPV 18-L1 gene in the pcDNA3 expression vector was successfully confirmed by colony PCR test and enzyme digestion reaction, and the results indicate the production of recombinant plasmid pCDNA3.1-L1. Finally, the evaluation of the L1 gene at the mRNA expression level showed the successful expression of the L1 gene in the eukaryotic system. Conclusion: The results of this research show the effectiveness of the constructed expression vector in the effective expression of the L1 gene in vitro. This expression vector can be used as a DNA vaccine in future studies.

IntrouductionIn recent years, the role of enterprises (high-yield) in developed countries as well as developing countries is increasing. Enterprises are one of the most important and vital units active in today's societies that can be helped to solve the problem of unemployment, increase production and national exports with proper planning as well as supportive and regulatory solutions. But today, these enterprises face many obstacles. According to available statistics, about 23% of small units in the first year and about 42% at the end of the fifth year have failed for various reasons and have been forced to stop operating. Zabol city Enterprises, Islamabad and Hosseinabad districts are no exception to this rule. Due to lack of necessary skills and expertise, the majority of residents in these areas are not attracted to the formal sector of the urban economy and are employed in informal jobs. Considering that about 90% of the economic enterprises in these neighborhoods are serviced and commercial enterprises, and due to the unfavorable economic situation and low income, these enterprises cannot survive in the field of competition, and as a result, the owner enterprises are forced to close down. Considering the importance of the development of economic enterprises in Sistan region and its important role on the sustainability of employment and even continuoued job creation, the above article aims to investigate the obstacles to the development of economic enterprises in Islamabad and Hosseinabad neighborhoods.Data and MethodThe method in this research is descriptive-analytical. The statistical population of this research is economic enterprises located in Islamabad and Hosseinabad neighborhoods (226) which then, according to the number of economic enterprises in the above neighborhoods (142 enterprises), 142 enterprises have been calculated as the sample size of enterprises using Cochran's formula at 95% confidence level. Of these, 88 enterprises in Islamabad neighborhood and 54 enterprises are located in Hosseinabad neighborhood. To collect information, in addition to library studies and field observations and interviews with enterprise owners, indicators appropriate for the enterprises in the study area were determined. Based on the determined indicators, the studied enterprises questionnaires have been prepared. To analyze the data, Shannon and Saw entropy multivariate decision weighting models have been used. Also, in order to analyze the data, SPSS software was used along with one-sample t-test. Results and DiscussionIn order to assess the barriers to the development of enterprises in (Islam Abad and Hossein Abad neighborhoods), several methods are used, which are different based on the purpose of the study and the expertise level and analysis method. In order to determine the weight and importance of the selected indicators using the opinions of the respondents, the entropy coefficient was used. Finally, in order to obtain accurate final results, the final weight obtained for the indicators was multiplied by the data (items) obtained from the respondents' questionnaire. The weight assigned to each selected indicator is calculated and presented. Political obstacles (lack of a single trustee in the field of development of small and medium enterprises, problems for exporting goods inside and outside the country), weighing 0.246, have the highest amount of obstacles. Financial barriers (disproportion of capital and labor, fluctuations in raw material prices, retail sales of products, trade sanctions on Iran, high inflation in the country, financial problems of enterprises, reduced liquidity, high bank interest rates) with a weight of 0.200 has second rank and skills-training barriers (lack of labor skills, low level of education in the labor force, unwillingness to consult marketing, weakness in economic, financial and managerial knowledge); With a weight of 0.189, it has third rank. Then, indicators of legal obstacles (necessary instability in regulations, rules and policies of foreign exchange and trade, lack of timely implementation of government incentive policies such as tax exemptions and export bonuses, insufficient facilities and financial and non-financial support provided by small and medium enterprises, administrative barriers to receiving facilities, lack of specialized banks to pay facilities to small enterprises, lack of unity of procedure between banks in providing facilities to enterprises, the existence of numerous and sometimes contradictory laws in the country) with a weight of 0.188, have fourth rank and indicators of infrastructure barriers (weakness of local constructions, being in the false place, lack of suitable bandwidth for the Internet) with a weight of 0.187 have the lowest rank. Also, in describing the barriers to the development of enterprises in the studied neighborhoods based on the saw method, an Islam Abad neighborhood with a final score 0.507 has the highest and Hossein Abad with 0.490 has the lowest level of development barriers.ConclusionComparing the results of the present study with other similar studies shows that some of the results are consistent and contradictory. According to the research findings, political barriers (lack of a single trustee in the field of development of small and medium-sized enterprises, problems for exporting goods inside and outside the country), weighing 0.246, have highest number of barriers to the development of enterprises. These results are consistent with the findings of the study (Rezaei and colleague, 2015). In the study of Rezaei and colleague, among the six factors extracted, the political-infrastructural factor with a value 3.715 alone explains 17.38% of the total variance. Also, the third barrier for the development of economic enterprises was the financial barriers that have been emphasized in the research (Zargar and Beidakhti, 2011).

Background and purpose: Acyl-CoA synthetase (ACS) enzymes play an important role in the activation of fatty acids. While many studies have found correlations between the expression levels of ACS enzymes with the progression, growth, and survival of cancer cells, their role and expression patterns in colon adenocarcinoma are still greatly unknown and demand further investigation. Experimental approach: The expression data of colon adenocarcinoma samples were downloaded from the Cancer Genome Atlas (TCGA) database. Normalization and differential expression analysis were performed to identify differentially expressed genes (DEGs). Gene set enrichment analysis was applied to identify top enriched genes from ACS enzymes in cancer samples. Gene ontology and protein-protein interaction analyses were performed for the prediction of molecular functions and interactions. Survival analysis and receiver operating characteristic test (ROC) were performed to find potential prognostic and diagnostic biomarkers. Findings/Results: ACSL6 and ACSM5 genes demonstrated more significant differential expression and LogFC value compared to other ACS enzymes and also achieved the highest enrichment scores. Gene ontology analysis predicted the involvement of top DEGs in fatty acids metabolism, while protein-protein interaction network analysis presented strong interactions between ACSLs, ACSSs, ACSMs, and ACSBG enzymes with each other. Survival analysis suggested ACSM3 and ACSM5 as potential prognostic biomarkers, while the ROC test predicted stronger diagnostic potential for ACSM5, ACSS2, and ACSF2 genes. Conclusion and implications: Our findings revealed the expression patterns, prognostic, and diagnostic biomarker potential of ACS enzymes in colon adenocarcinoma. ACSM3, ACSM5, ACSS2, and ACSF2 genes are suggested as possible prognostic and diagnostic biomarkers.

In this paper, a D-band varactor-based tunable bandpass filter is proposed in 65nm CMOS Technology. The filter is composed of coupled lines loaded with a pair of MOSCAPs that control the passband of the filter. The effects of MOSCAP parameters in terms of the quality factor and the tuning range are studied. The proper placement of the MOSCAP along the resonator is the key parameter to keep insertion loss as low as possible while the tuning range remains intact. A cross-coupled line between input/output ports introduces a pair of transmission zeros and significantly reduces the size of the filter. The tuning range of the proposed structure is 10 % (136 $\sim $ 150 GHz). For this frequency band, the fractional bandwidth (FBW) varies between 10.9 and 11.8 % and the in-band insertion loss is between 4 and 8.2 dB. The overall size of the filter is $0.11\lambda b _{0} \times 0.095\lambda b _{0}$ . Measurements for the filter show good agreement with the simulation results.

Abstract PD-L1 is one of the most important immune checkpoint molecules in breast cancer that plays an important role in suppressing the immune system when confronted with tumor cells and is regulated by various microRNAs. Among them, microRNA-335-3p and microRNA-145-5p, regulated by DNA methylation, have tumor suppressor activities. We studied the role of miR-335 and -145 on PD-L1 suppression in breast cancer. The expression of miR-355 and miR-145 was significantly downregulated in BC tissues and cell lines compared to their controls, and their downregulation was negatively correlated with PD‐L1 overexpression. In-silico and luciferase reporter systems confirmed that miR-335 and -145 target PD-L1. In BC tissues and cell lines, cancer-specific methylation was found in CpG-rich areas upstream of miR-335 and-145, and up-regulation of PD-L1 expression was connected with hypermethylation (r = 0.4089, P = 0.0147, and r = 0.3373, P = 0.0475, respectively). The higher levels of miR-355 and -145 in BC cells induced apoptosis, arrested the cell cycle, and reduced proliferation significantly. In summary, we found that miR-335 and -145 are novel tumor suppressors inactivated in BC, and these miRs may serve as potential therapeutic targets for breast cancer treatment.

Introduction: In clinical practice, distinguishing invasive lung tumors from primary tumors remains a challenge. With recent advances in understanding biological alterations of tumorigenesis and molecular analytic technologies, using these molecular alterations can be sensitive and tumor-specific as biomarker for the stratification of patients. In this study, the molecular network of miRNA-mRNA contributing to primary lung cancer has been assessed by bioinformatics approaches. Methods: In this analytical-observational study gene expression profiles of patients with primary lung cancer were collected from the RNASeq data of the Cancer Genome Atlas (TCGA) database by TCGAbiolinks package. With edgeR and limma packages in R, non-specific expression genes were filtered and the significant differentially expressed mRNAs and miRNAs between tumor tissues and normal tissues were saved and their targets were predicted by 2 databases; miRWalk, and Targetscan. Subsequently, the interaction regulatory network of miRNA-mRNA was visualized using Cytoscape software. Results: By miRNA-mRNA network analysis revealed that, 7 miRNAs included; hsa-miR-373-3p, hsa-let-7a-5p, hsa-miR-23b-3p, hsa-miR-152-3p, hsa-miR -216a-3p, hsa-miR-106-5p, hsa-let-7i-5p and 6 miRNAs including; has-miR-107, has-miR-17-5p, has-185-5p, has-miR-34a- 5p, has-miR-130a-5p and has-96-5p, mediated regulation of up-regulated and down-regulated mRNAs in primary lung cancer patients, respectively. Conclusion: This bioinformatics study proposes a miRNA–mRNA network associated with primary lung cancer, which may help to screening and new therapeutic targets for primary lung cancer as prognostic marker.

Abstract Solanum nigrum L. (Black nightshade), is one of the most troublesome weeds of summer crops such as corn, soybean, sunflower, etc. To study the effect of combined Castor oil as an adjuvant with different doses of Lumax (Mesotrion + S-metolacholor + Terbuthylazine) on the physiological behavior of Solanum nigrum L., a greenhouse experiment was conducted in randomized complete block design with four replications in agricultural faculty of the University of Tabriz in 2021. A foliar application of Lumax increased proline, malondialdehyde, and hydrogen peroxide concentrations and superoxide dismutase, catalase, and peroxidase activity. The content of protein and photosynthetic pigments (Chlorophyll a, b, and carotenoids) also decreased significantly by using Lumax herbicide. Applying castor oil in combination with Lumax intensifies oxidative stress and lipid peroxidation. Results showed that by increasing the herbicide doses in comparison with control (non-herbicide), Area, Fm, Fv, Fv/Fm, Fv/F0, Sm, Sm/Tfm, and Fv/F0 decreased 48.32%, 19.52%, 27.95%, 10.47%, 50.90%, 28.34%, 79.38%, and 50.90%, respectively and F0, F0/Fm increased 46.76% and 82.38%, respectively. Castor oil showed a synergistic effect on Lumax herbicide and enhanced its efficacy on Solanum nigrum. The presented results supported the view that by evaluating chlorophyll a fluorescence parameters, we would realize herbicide (alone or mixed with any adjacent) efficacy before the visual symptoms appear in the plant.

Background and purpose: Precise structures of macromolecules are important for structure-based drug design. Due to the limited resolution of some structures obtained from X-ray diffraction crystallography, differentiation between the NH and O atoms can be difficult. Sometimes a number of amino acids are missing from the protein structure. In this research, we intend to introduce a small database that we have prepared for providing the corrected 3D structure files of proteins frequently used in structure-based drug design protocols. Experimental approach: 3454 soluble proteins belonging to the cancer signaling pathways were collected from the PDB database from which a dataset of 1001 was obtained. All were subjected to corrections in the protein preparation step. 896 protein structures out of 1001 were corrected successfully and the decision on the remained 105 proposed twelve for homology modeling to correct the missing residues. Three of them were subjected to molecular dynamics simulation for 30 ns. Findings / Results: 896 corrected proteins were perfect and homology modeling on 12 proteins with missing residues in the backbone resulted in acceptable models according to Ramachandran, z-score, and DOPE energy plots. RMSD, RMSF, and Rg values verified the stability of the models after 30 ns molecular dynamics simulation. Conclusion and implication: A collection of 1001 proteins were modified for some defects such as adjustment of the bond orders and formal charges, and addition of missing side chains of residues. Homology modeling corrected the amino missing backbone residues. This database will be completed for quite a lot of water-soluble proteins to be uploaded to the internet.

The mann fixed point algorithm play an importmant role in the approximation of fixed points of nonexpansive operators. In this paper, by considering new conditions, we prove the weak convergence of mann fixed point algorithm, for finding a common fixed point of two nonexpansive mappings in real Hilbert spaces. This results extend the privious results given by Kanzow and Shehu. Finally, we give an application of our results, by using the John von Neumann's method.

Abstract Background: Citrullinemia type 1 is an autosomal recessive disease resulting in ammonia accumulation in the blood, and if uncontrolled may progress to coma or death in the early months after birth. Cases presentation: 7 families from Southwest Iran having one or more children in their families or relatives, who died in the early months after birth due to citrullinemia type 1 visited for genetic counseling and prenatal diagnosis. Whole-exome sequencing was performed on peripheral blood specimens and chorionic villus samples. Sanger sequencing confirmed the genetic results. Both parents were identified as carriers for the exon 15 c.1168G > A mutation in each family. The fetus in 6 out of 7 families was homozygote for A substitution on the argininosuccinate synthetase 1 gene. Conclusion: The presence of a common mutation in the argininosuccinate synthetase 1gene in all affected families of Southwest Iran shows a possible population cluster in this area.

Objective: Multiple sclerosis (MS) is a chronic disease of the central nervous system that is usually diagnosed at the working-age (20-45 years) and can negatively affect patients' job performance and ability in work. The purpose of this study was to investigate occupational, individual, and disease-related factors in the return to work in patients with MS. Materials and Methods: This study was performed on all patients with clinically definite MS according to the McDonald criteria who were referred to a neurology clinic from September 2019 to April 2020. The Health and Safety Executive Questionnaire and Multidimensional Fatigue Inventory Questionnaire were used to assess job stress and fatigue level. Level of disability was assessed in patients through the validated version of the Expanded Disability Status Scale (EDSS). Based on the patients' return to work status, individuals were divided into two groups: the patients who returned to work (full time, part-time) and who did not return to work. Then, these two groups were compared in terms of occupational, individual, and disease-related factors. Results: Of 191 patients with MS, 127 (64%) returned to work after one year of diagnosis. The rate of returning to work was higher among younger patients, males and patients with the relapsing-remitting MS. Physical jobs, moderate level of neurological disability (EDSS >3) and severe fatigue were independently associated with unemployment. Conclusion: Findings of our study showed that older age, female gender, having a physical job, neurological disability, and severe fatigue were associated with no return to work in MS patients. Due to the high prevalence of MS in young people at working age, facilitating employment, adjusting factors related to the work environment, and support of colleagues and supervisors can play an important role in reducing stress and improving the general condition of the disease in these patients.

Abstract Objectives This systematic review aims to investigate the effect of different preparation designs on the marginal fit and fracture strength of ceramic occlusal veneers. Materials and Methods Based on the PICO question and the search terms, an electronic search was performed in Google Scholar, PubMed (MEDLINE), Scopus, Cochrane Library, Web of Science, Science Direct, Wiley, Ovid, and SAGE for articles published up to July 2022. After including English in vitro studies that evaluated posterior ceramic occlusal overlays at the posterior with ceramic restorations by following the PRISMA statement, the extracted data was tabulated. The methodological quality of the included studies was evaluated. Risk of bias assessment was done independently by two authors using the modified MINORS scale. Results About 3138 search results were screened, of which 22 were selected due to their titles. Twenty‐one full‐text articles were assessed for eligibility. Seventeen in‐vitro studies were finalized for the extraction of quantitative data. All 17 articles had a low risk of bias and were retained. The influencing items for evaluating the research were different in most studies; therefore, qualitative synthesis of the results was feasible. They generally included preparation design, material thickness, depth of preparation in the tooth, internal divergence angle, and finish line. Meta‐analysis was not done due to heterogeneity of preparation types and evaluation methods. Results revealed that fracture resistance of occlusal veneers is higher than normal mastication force, and it is sufficient to prepare the occlusal surface, use a self‐etching primer for bonding, and an acceptable minimum ceramic thickness. The marginal discrepancy of occlusal veneers is clinically acceptable. However, this systematic review faces some limitations due to the lack of in vivo studies, different preparation designs in included studies, different follow‐ups, and lack of comprehensive explanations in articles. Conclusions The preparation design of occlusal veneers influences both marginal adaptation and fracture resistance. Various preparation designs are proven to have clinically acceptable fracture strength and marginal adaptation.

This article explores the models and frameworks developed on "research impact'. We aim to provide a comprehensive overview of related literature through scoping study method. The present research investigates the nature, objectives, approaches, and other main attributes of the research impact models. It examines to analyze and classify models based on their characteristics. Forty-seven studies and 10 reviews published between 1996 and 2020 were included in the analysis. The majority of models were developed for the impact assessment and evaluation purposes. We identified three approaches in the models, namely outcome-based, process-based, and those utilized both of them, among which the outcome-based approach was the most frequently used by impact models and evaluation was considered as the main objective of this group. The process-based ones were mainly adapted from the W.K. Kellogg Foundation logic model and were potentially eligible for impact improvement. We highlighted the scope of processes and other specific features for the recent models. Given the benefits of the process-based approach in enhancing and accelerating the research impact, it is important to consider such approach in the development of impact models. Effective interaction between researchers and stakeholders, knowledge translation, and evidence synthesis are the other possible driving forces contributing to achieve and improve impact.