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101. Maternally Inherited Differences within Mitochondrial Complex I Control Murine Healthspan

Author

Hirose, Misa, primary, Schilf, Paul, additional, Zarse, Kim, additional, Busch, Hauke, additional, Fuellen, Georg, additional, Jöhren, Olaf, additional, Köhling, Rüdiger, additional, König, Inke R., additional, Richer, Barbara, additional, Rupp, Jan, additional, Schwaninger, Markus, additional, Seeger, Karsten, additional, Sina, Christian, additional, Ristow, Michael, additional, and Ibrahim, Saleh M., additional

Published
2019
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104. A tissue-specific landscape of sense/antisense transcription in the mouse intestine

Author

Sina Christian, Kreck Benjamin, Gavrilova Olga, Franke Andre, Häsler Robert, Wittig Michael, Barann Matthias, Klostermeier Ulrich C, Schilhabel Markus B, Schreiber Stefan, and Rosenstiel Philip

Subjects
Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background The intestinal mucosa is characterized by complex metabolic and immunological processes driven highly dynamic gene expression programs. With the advent of next generation sequencing and its utilization for the analysis of the RNA sequence space, the level of detail on the global architecture of the transcriptome reached a new order of magnitude compared to microarrays. Results We report the ultra-deep characterization of the polyadenylated transcriptome in two closely related, yet distinct regions of the mouse intestinal tract (small intestine and colon). We assessed tissue-specific transcriptomal architecture and the presence of novel transcriptionally active regions (nTARs). In the first step, signatures of 20,541 NCBI RefSeq transcripts could be identified in the intestine (74.1% of annotated genes), thereof 16,742 are common in both tissues. Although the majority of reads could be linked to annotated genes, 27,543 nTARs not consistent with current gene annotations in RefSeq or ENSEMBL were identified. By use of a second independent strand-specific RNA-Seq protocol, 20,966 of these nTARs were confirmed, most of them in vicinity of known genes. We further categorized our findings by their relative adjacency to described exonic elements and investigated regional differences of novel transcribed elements in small intestine and colon. Conclusions The current study demonstrates the complexity of an archetypal mammalian intestinal mRNA transcriptome in high resolution and identifies novel transcriptionally active regions at strand-specific, single base resolution. Our analysis for the first time shows a strand-specific comparative picture of nTARs in two tissues and represents a resource for further investigating the transcriptional processes that contribute to tissue identity.

Published
2011
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106. Dietary ursolic acid improves health span and life span in male Drosophila melanogaster

Author

Staats, Stefanie, primary, Wagner, Anika E., additional, Lüersen, Kai, additional, Künstner, Axel, additional, Meyer, Timo, additional, Kahns, Anna K., additional, Derer, Stefanie, additional, Graspeuntner, Simon, additional, Rupp, Jan, additional, Busch, Hauke, additional, Sina, Christian, additional, Ipharraguerre, Ignacio R., additional, and Rimbach, Gerald, additional

Published
2018
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107. Maternally inherited differences within mitochondrial Complex I control murine healthspan

Author

Hirose, Misa, primary, Schilf, Paul, additional, Zarse, Kim, additional, Busch, Hauke, additional, Füllen, Georg, additional, Jöhren, Olaf, additional, Köhling, Rüdiger, additional, König, Inke R, additional, Richer, Barbara, additional, Rupp, Jan, additional, Schwaninger, Markus, additional, Seeger, Karsten, additional, Sina, Christian, additional, Ristow, Michael, additional, and Ibrahim, Saleh M, additional

Published
2018
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108. Heterozygous P32 / C1QBP / HABP1 Polymorphism rs56014026 Reduces Mitochondrial Oxidative Phosphorylation and Is Expressed in Low-grade Colorectal Carcinomas.

Author

Raschdorf, Annika, Sünderhauf, Annika, Skibbe, Kerstin, Ghebrehiwet, Berhane, Peerschke, Ellinor I., Sina, Christian, and Derer, Stefanie

Subjects
OXIDATIVE phosphorylation, COLON cancer, SINGLE nucleotide polymorphisms, MITOCHONDRIA, MITOCHONDRIAL proteins, CANCER cell differentiation
Abstract

Rapid proliferation of cancer cells is enabled by favoring aerobic glycolysis over mitochondrial oxidative phosphorylation (OXPHOS). P32 (C1QBP /gC1qR) is essential for mitochondrial protein translation and thus indispensable for OXPHOS activity. It is ubiquitously expressed and directed to the mitochondrial matrix in almost all cell types with an excessive up-regulation of p32 expression reported for tumor tissues. We recently demonstrated high levels of non-mitochondrial p32 to be associated with high-grade colorectal carcinoma. Mutations in human p32 are likely to disrupt proper mitochondrial function giving rise to various diseases including cancer. Hence, we aimed to investigate the impact of the most common single nucleotide polymorphism (SNP) rs56014026 in the coding sequence of p32 on tumor cell metabolism. In silico homology modeling of the resulting p.Thr130Met mutated p32 revealed that the single amino acid substitution potentially induces a strong conformational change in the protein, mainly affecting the mitochondrial targeting sequence (MTS). In vitro experiments confirmed an impaired mitochondrial import of mutated p32-T130M, resulting in reduced OXPHOS activity and a shift towards a low metabolic phenotype. Overexpression of p32-T130M maintained terminal differentiation of a goblet cell-like colorectal cancer cell line compared to p32-wt without affecting cell proliferation. Sanger sequencing of tumor samples from 128 CRC patients identified the heterozygous SNP rs56014026 in two well-differentiated, low proliferating adenocarcinomas, supporting our in vitro data. Together, the SNP rs56014026 reduces metabolic activity and proliferation while promoting differentiation in tumor cells. [ABSTRACT FROM AUTHOR]

Published
2021
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109. Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling

Author

Giles, Daniel A, Moreno-Fernandez, Maria E, Stankiewicz, Traci E, Graspeuntner, Simon, Cappelletti, Monica, Wu, David, Mukherjee, Rajib, Chan, Calvin C, Lawson, Matthew J, Klarquist, Jared, Sünderhauf, Annika, Softic, Samir, Kahn, C Ronald, Stemmer, Kerstin, Iwakura, Yoichiro, Aronow, Bruce J, Karns, Rebekah, Steinbrecher, Kris A, Karp, Christopher L, Sheridan, Rachel, Shanmukhappa, Shiva K, Reynaud, Damien, Haslam, David B, Sina, Christian, Rupp, Jan, Hogan, Simon P, and Divanovic, Senad

Subjects
Biological sciences, Health
Abstract

Author(s): Daniel A Giles; Maria E Moreno-Fernandez; Traci E Stankiewicz; Simon Graspeuntner; Monica Cappelletti; David Wu; Rajib Mukherjee; Calvin C Chan; Matthew J Lawson; Jared Klarquist; Annika Sünderhauf; Samir Softic; [...]

Published
2017
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115. Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease

Author

Moreno-Fernandez, Maria E., primary, Giles, Daniel A., additional, Stankiewicz, Traci E., additional, Sheridan, Rachel, additional, Karns, Rebekah, additional, Cappelletti, Monica, additional, Lampe, Kristin, additional, Mukherjee, Rajib, additional, Sina, Christian, additional, Sallese, Anthony, additional, Bridges, James P., additional, Hogan, Simon P., additional, Aronow, Bruce J., additional, Hoebe, Kasper, additional, and Divanovic, Senad, additional

Published
2018
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118. Regulation of epithelial cell expressed C3 in the intestine – Relevance for the pathophysiology of inflammatory bowel disease?

Author

Sünderhauf, Annika, primary, Skibbe, Kerstin, additional, Preisker, Sophie, additional, Ebbert, Karen, additional, Verschoor, Admar, additional, Karsten, Christian M., additional, Kemper, Claudia, additional, Huber-Lang, Markus, additional, Basic, Marijana, additional, Bleich, André, additional, Büning, Jürgen, additional, Fellermann, Klaus, additional, Sina, Christian, additional, and Derer, Stefanie, additional

Published
2017
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120. Effects of Gliadin consumption on the Intestinal Microbiota and Metabolic Homeostasis in Mice Fed a High-fat Diet

Author

Zhang, Li, Andersen, Daniel, Roager, Henrik Munch, Bahl, Martin Iain, Hansen, Camilla Hartmann Friis, Danneskiold-Samsøe, Niels Banhos, Kristiansen, Karsten, Radulescu, Ilinca Daria, Sina, Christian, Frandsen, Henrik Lauritz, Hansen, Axel Kornerup, Brix, Susanne, Hellgren, Lars I., Licht, Tine Rask, Zhang, Li, Andersen, Daniel, Roager, Henrik Munch, Bahl, Martin Iain, Hansen, Camilla Hartmann Friis, Danneskiold-Samsøe, Niels Banhos, Kristiansen, Karsten, Radulescu, Ilinca Daria, Sina, Christian, Frandsen, Henrik Lauritz, Hansen, Axel Kornerup, Brix, Susanne, Hellgren, Lars I., and Licht, Tine Rask

Abstract

Dietary gluten causes severe disorders like celiac disease in gluten-intolerant humans. However, currently understanding of its impact in tolerant individuals is limited. Our objective was to test whether gliadin, one of the detrimental parts of gluten, would impact the metabolic effects of an obesogenic diet. Mice were fed either a defined high-fat diet (HFD) containing 4% gliadin (n = 20), or a gliadin-free, isocaloric HFD (n = 20) for 23 weeks. Combined analysis of several parameters including insulin resistance, histology of liver and adipose tissue, intestinal microbiota in three gut compartments, gut barrier function, gene expression, urinary metabolites and immune profiles in intestinal, lymphoid, liver and adipose tissues was performed. Mice fed the gliadin-containing HFD displayed higher glycated hemoglobin and higher insulin resistance as evaluated by the homeostasis model assessment, more hepatic lipid accumulation and smaller adipocytes than mice fed the gliadin-free HFD. This was accompanied by alterations in the composition and activity of the gut microbiota, gut barrier function, urine metabolome, and immune phenotypes within liver and adipose tissue. Our results reveal that gliadin disturbs the intestinal environment and affects metabolic homeostasis in obese mice, suggesting a detrimental effect of gluten intake in gluten-tolerant subjects consuming a high-fat diet.

Published
2017

121. Additional file 6: Figure S3. of Male-specific association between MT-ND4 11719 A/G polymorphism and ulcerative colitis: a mitochondria-wide genetic association study

Author

Dankowski, Theresa, Schröder, Torsten, Möller, Steffen, Xinhua Yu, Ellinghaus, David, Bär, Florian, Fellermann, Klaus, Lehnert, Hendrik, Schreiber, Stefan, Franke, Andre, Sina, Christian, Ibrahim, Saleh, and König, Inke

Abstract

Results of SNP based association analysis in the female subgroup of the initial sample. Horizontal line located at 0.01. (DOC 33 kb)

Published
2016
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122. Additional file 7: Table S4. of Male-specific association between MT-ND4 11719 A/G polymorphism and ulcerative colitis: a mitochondria-wide genetic association study

Author

Dankowski, Theresa, Schröder, Torsten, Möller, Steffen, Xinhua Yu, Ellinghaus, David, Bär, Florian, Fellermann, Klaus, Lehnert, Hendrik, Schreiber, Stefan, Franke, Andre, Sina, Christian, Ibrahim, Saleh, and König, Inke

Abstract

Results for the top 50 nuclear SNPs according to p value for interaction with rs2853495 in the total initial sample, sorted by chromosomal positions. (DOC 86 kb)

Published
2016
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123. Additional file 1: Table S1. of Male-specific association between MT-ND4 11719 A/G polymorphism and ulcerative colitis: a mitochondria-wide genetic association study

Author

Dankowski, Theresa, Schröder, Torsten, Möller, Steffen, Xinhua Yu, Ellinghaus, David, Bär, Florian, Fellermann, Klaus, Lehnert, Hendrik, Schreiber, Stefan, Franke, Andre, Sina, Christian, Ibrahim, Saleh, and König, Inke

Abstract

Characteristics of UC cases used in the initial analysis. (DOC 42 kb)

Published
2016
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124. Additional file 4: Figure S1. of Male-specific association between MT-ND4 11719 A/G polymorphism and ulcerative colitis: a mitochondria-wide genetic association study

Author

Dankowski, Theresa, Schröder, Torsten, Möller, Steffen, Xinhua Yu, Ellinghaus, David, Bär, Florian, Fellermann, Klaus, Lehnert, Hendrik, Schreiber, Stefan, Franke, Andre, Sina, Christian, Ibrahim, Saleh, and König, Inke

Abstract

Results of SNP based association analysis in the total initial sample. Horizontal line located at 0.01. (DOC 33 kb)

Published
2016
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125. Additional file 3: Table S3. of Male-specific association between MT-ND4 11719 A/G polymorphism and ulcerative colitis: a mitochondria-wide genetic association study

Author

Dankowski, Theresa, Schröder, Torsten, Möller, Steffen, Xinhua Yu, Ellinghaus, David, Bär, Florian, Fellermann, Klaus, Lehnert, Hendrik, Schreiber, Stefan, Franke, Andre, Sina, Christian, Ibrahim, Saleh, and König, Inke

Abstract

Allele counts in the tested haplogroups assigned with HaploGrep (Kloss-Brandstätter 2011 Hum Mutat 32:25–32). Base pair position and allele are shown for all markers. (DOC 107 kb)

Published
2016
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127. Additional file 5: Figure S2. of Male-specific association between MT-ND4 11719 A/G polymorphism and ulcerative colitis: a mitochondria-wide genetic association study

Author

Dankowski, Theresa, Schröder, Torsten, Möller, Steffen, Xinhua Yu, Ellinghaus, David, Bär, Florian, Fellermann, Klaus, Lehnert, Hendrik, Schreiber, Stefan, Franke, Andre, Sina, Christian, Ibrahim, Saleh, and König, Inke

Abstract

Results of SNP based association analysis in the male subgroup of the initial sample. Horizontal line located at 0.01. (DOC 34 kb)

Published
2016
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128. Additional file 2: Table S2. of Male-specific association between MT-ND4 11719 A/G polymorphism and ulcerative colitis: a mitochondria-wide genetic association study

Author

Dankowski, Theresa, Schröder, Torsten, Möller, Steffen, Xinhua Yu, Ellinghaus, David, Bär, Florian, Fellermann, Klaus, Lehnert, Hendrik, Schreiber, Stefan, Franke, Andre, Sina, Christian, Ibrahim, Saleh, and König, Inke

Abstract

Haplogroup frequencies in our sample and given by Mitomap ( http://www.mitomap.org/bin/view.pl/MITOMAP/HaplogroupMarkers , last accessed 15/09/2014). (DOC 43 kb)

Published
2016
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130. Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine

Author

Pagel, René, primary, Bär, Florian, additional, Schröder, Torsten, additional, Sünderhauf, Annika, additional, Künstner, Axel, additional, Ibrahim, Saleh M., additional, Autenrieth, Stella E., additional, Kalies, Kathrin, additional, König, Peter, additional, Tsang, Anthony H., additional, Bettenworth, Dominik, additional, Divanovic, Senad, additional, Lehnert, Hendrik, additional, Fellermann, Klaus, additional, Oster, Henrik, additional, Derer, Stefanie, additional, and Sina, Christian, additional

Published
2017
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131. Effects of Gliadin consumption on the Intestinal Microbiota and Metabolic Homeostasis in Mice Fed a High-fat Diet

Author

Zhang, Li, primary, Andersen, Daniel, additional, Roager, Henrik Munch, additional, Bahl, Martin Iain, additional, Hansen, Camilla Hartmann Friis, additional, Danneskiold-Samsøe, Niels Banhos, additional, Kristiansen, Karsten, additional, Radulescu, Ilinca Daria, additional, Sina, Christian, additional, Frandsen, Henrik Lauritz, additional, Hansen, Axel Kornerup, additional, Brix, Susanne, additional, Hellgren, Lars I., additional, and Licht, Tine Rask, additional

Published
2017
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132. Male-specific association between MT-ND4 11719 A/G polymorphism and ulcerative colitis: a mitochondria-wide genetic association study

Author

Dankowski, Theresa, primary, Schröder, Torsten, additional, Möller, Steffen, additional, Yu, Xinhua, additional, Ellinghaus, David, additional, Bär, Florian, additional, Fellermann, Klaus, additional, Lehnert, Hendrik, additional, Schreiber, Stefan, additional, Franke, Andre, additional, Sina, Christian, additional, Ibrahim, Saleh M., additional, and König, Inke R., additional

Published
2016
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134. Dietary ursolic acid improves health span and life span in male Drosophila melanogaster.

Author

Staats, Stefanie, Wagner, Anika E., Lüersen, Kai, Künstner, Axel, Meyer, Timo, Kahns, Anna K., Derer, Stefanie, Graspeuntner, Simon, Rupp, Jan, Busch, Hauke, Sina, Christian, Ipharraguerre, Ignacio R., and Rimbach, Gerald

Subjects
DROSOPHILA melanogaster, LIFE spans, URSOLIC acid, LONGEVITY, MUSCLE strength, DROSOPHILA
Abstract

The health and life span of Drosophila melanogaster are partly determined by intestinal barrier integrity, metabolic rate as well as stress response and the expression of longevity‐associated genes, depending on genetic and dietary factors. Ursolic acid (UA) is a naturally occurring triterpenoid exhibiting potential antimicrobial, anti‐inflammatory, and antiobesity activity and counteracting age‐related deficits in muscle strength. In this study, UA was dietarily administered to w1118D. melanogaster which significantly elongated the health and life span of males. Spargel (srl) is the Drosophila orthologue of mammalian peroxisome proliferator‐activated receptor‐gamma coactivator 1 α(PGC1α), an important regulator of energy homeostasis and mitochondrial function. Our results indicate that the health‐promoting effect of UA, demonstrated by a significant increase in climbing activity, occurs via an upregulation of srl expression leading to a metabolic shift in the fly without reducing fecundity or gut integrity. Moreover, UA affected the flies' microbiota in a manner that contributed to life span extension. Srl expression and microbiota both seem to be affected by UA, as we determined by using srl‐mutant and axenic flies. © 2018 BioFactors, 45(2):169–186, 2019 [ABSTRACT FROM AUTHOR]

Published
2019
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136. Dietary fat drives whole-body insulin resistance and promotes intestinal inflammation independent of body weight gain

Author

Jensen, Benjamin Anderschou Holbech, Nielsen, Thomas Svava, Fritzen, Andreas Mæchel, Holm, Jacob Bak, Fjære, Even, Serup, Annette Karen Lundbeck, Borkowski, Kamil, Risis, Steve, Pærregaard, Simone I., Søgaard, Ida, Poupeau, Audrey Angélique G, Poulsen, Michelle, Ma, Tao, Sina, Christian, Kiens, Bente, Madsen, Lise, Kristiansen, Karsten, Treebak, Jonas Thue, Jensen, Benjamin Anderschou Holbech, Nielsen, Thomas Svava, Fritzen, Andreas Mæchel, Holm, Jacob Bak, Fjære, Even, Serup, Annette Karen Lundbeck, Borkowski, Kamil, Risis, Steve, Pærregaard, Simone I., Søgaard, Ida, Poupeau, Audrey Angélique G, Poulsen, Michelle, Ma, Tao, Sina, Christian, Kiens, Bente, Madsen, Lise, Kristiansen, Karsten, and Treebak, Jonas Thue

Abstract

BACKGROUND: The obesogenic potential of high-fat diets (HFD) in rodents is attenuated when the protein:carbohydrate ratio is increased. However, it is not known if intake of an HFD irrespective of the protein:carbohydrate ratio and in the absence of weight gain, affects glucose homeostasis and the gut microbiota.METHODS: We fed C57BL6/J mice 3 different HFDs with decreasing protein:carbohydrate ratios for 8weeks and compared the results to a LFD reference group. We analyzed the gut microbiota composition by 16S rDNA amplicon sequencing and the intestinal gene expression by real-time PCR. Whole body glucose homeostasis was evaluated by insulin and glucose tolerance tests as well as by a hyperinsulinemic euglycemic clamp experiment.RESULTS: Compared with LFD-fed reference mice, HFD-fed mice, irrespective of protein:carbohydrate ratio, exhibited impaired glucose tolerance, whereas no differences were observed during insulin tolerance tests. The hyperinsulinemic euglycemic clamp revealed tissue-specific effects on glucose homeostasis in all HFD-fed groups. HFD-fed mice exhibited decreased insulin-stimulated glucose uptake in white but not in brown adipose tissue, and sustained endogenous glucose production under insulin-stimulated conditions. We observed no impairment of insulin-stimulated glucose uptake in skeletal muscles of different fiber type composition. HFD-feeding altered the gut microbiota composition paralleled by increased expression of pro-inflammatory cytokines and genes involved in gluconeogenesis in intestinal epithelial cells of the jejunum.CONCLUSIONS: Intake of a HFD profoundly affected glucose homeostasis, gut inflammatory responses, and gut microbiota composition in the absence of fat mass accretion.

Published
2016

137. Uncoupling protein 2 protects mice from aging

Author

Hirose, Misa, primary, Schilf, Paul, additional, Lange, Falko, additional, Mayer, Johannes, additional, Reichart, Gesine, additional, Maity, Pallab, additional, Jöhren, Olaf, additional, Schwaninger, Markus, additional, Scharffetter-Kochanek, Karin, additional, Sina, Christian, additional, Sadik, Christian D., additional, Köhling, Rüdiger, additional, Miroux, Bruno, additional, and Ibrahim, Saleh M., additional

Published
2016
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138. Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis

Author

Jendrek, Sebastian Torben, primary, Gotthardt, Daniel, additional, Nitzsche, Thomas, additional, Widmann, Laila, additional, Korf, Tobias, additional, Michaels, Maike Anna, additional, Weiss, Karl-Heinz, additional, Liaskou, Evaggelia, additional, Vesterhus, Mette, additional, Karlsen, Tom Hemming, additional, Mindorf, Swantje, additional, Schemmer, Peter, additional, Bär, Florian, additional, Teegen, Bianca, additional, Schröder, Torsten, additional, Ehlers, Marc, additional, Hammers, Christoph Matthias, additional, Komorowski, Lars, additional, Lehnert, Hendrik, additional, Fellermann, Klaus, additional, Derer, Stefanie, additional, Hov, Johannes Roksund, additional, and Sina, Christian, additional

Published
2016
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140. Pancreatic Autoantibodies Against CUZD1 and GP2 Are Associated with Distinct Clinical Phenotypes of Crohnʼs Disease

Author

Michaels, Maike Anna, primary, Jendrek, Sebastian Torben, additional, Korf, Tobias, additional, Nitzsche, Thomas, additional, Teegen, Bianca, additional, Komorowski, Lars, additional, Derer, Stefanie, additional, Schröder, Torsten, additional, Baer, Florian, additional, Lehnert, Henrik, additional, Büning, Jürgen, additional, Fellerman, Klaus, additional, and Sina, Christian, additional

Published
2015
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142. Sleep Loss Disrupts Morning-to-Evening Differences in Human White Adipose Tissue Transcriptome.

Author

Wilms, Britta, Leineweber, Elena M, Mölle, Matthias, Chamorro, Rodrigo, Pommerenke, Claudia, Salinas-Riester, Gabriela, Sina, Christian, Lehnert, Hendrik, Oster, Henrik, and Schmid, Sebastian M

Abstract

Chronodisruption, as caused by such conditions as perturbations of 24-hour rhythms of physiology and behavior, may promote the development of metabolic diseases.

Published
2019
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145. Carboxypeptidase E Modulates Intestinal Immune Homeostasis and Protects against Experimental Colitis in Mice

Author

Bär, Florian, primary, Föh, Bandik, additional, Pagel, René, additional, Schröder, Torsten, additional, Schlichting, Heidi, additional, Hirose, Misa, additional, Lemcke, Susanne, additional, Klinger, Antje, additional, König, Peter, additional, Karsten, Christian M., additional, Büning, Jürgen, additional, Lehnert, Hendrik, additional, Fellermann, Klaus, additional, Ibrahim, Saleh M., additional, and Sina, Christian, additional

Published
2014
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146. Mitochondrial Gene Polymorphisms That Protect Mice From Colitis

Author

Bär, Florian, primary, Bochmann, Wiebke, additional, Widok, Andrea, additional, von Medem, Kilian, additional, Pagel, Rene, additional, Hirose, Misa, additional, Yu, Xinhua, additional, Kalies, Kathrin, additional, König, Peter, additional, Böhm, Ruwen, additional, Herdegen, Thomas, additional, Reinicke, Anna T., additional, Büning, Jürgen, additional, Lehnert, Hendrik, additional, Fellermann, Klaus, additional, Ibrahim, Saleh, additional, and Sina, Christian, additional

Published
2013
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148. Tu1858 Extracellular Cathepsin K is Protective Against Chronic Intestinal Inflammation in Mice and Involved in Host-Microbe Homeostasis

Author

Lipinski, Simone, primary, Sina, Christian, additional, Aden, Konrad, additional, Gavrilova, Olga, additional, Till, Andreas, additional, Meyer-Hoffert, Ulf, additional, Podschun, Rainer, additional, Rittger, Andrea, additional, Haesler, Robert, additional, Rehman, Ateequr, additional, Pütsep, Katrin, additional, Schreiber, Stefan, additional, Saftig, Paul, additional, and Rosenstiel, Philip C., additional

Published
2012
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149. mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease

Author

Derer, Stefanie, primary, Till, Andreas, additional, Haesler, Robert, additional, Sina, Christian, additional, Grabe, Nils, additional, Jung, Sascha, additional, Nikolaus, Susanna, additional, Kuehbacher, Tanja, additional, Groetzinger, Joachim, additional, Rose-John, Stefan, additional, Rosenstiel, Philip C, additional, and Schreiber, Stefan, additional

Published
2012
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150. Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice

Author

Sina, Christian, primary, Lipinski, Simone, additional, Gavrilova, Olga, additional, Aden, Konrad, additional, Rehman, Ateequr, additional, Till, Andreas, additional, Rittger, Andrea, additional, Podschun, Rainer, additional, Meyer-Hoffert, Ulf, additional, Haesler, Robert, additional, Midtling, Emilie, additional, Pütsep, Katrin, additional, McGuckin, Michael A, additional, Schreiber, Stefan, additional, Saftig, Paul, additional, and Rosenstiel, Philip, additional

Published
2012
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