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102. HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses

Author

Eva Pigna, Alessandra Renzini, Emanuela Greco, Elena Simonazzi, Stefania Fulle, Rosa Mancinelli, Viviana Moresi, and Sergio Adamo

Subjects
HDAC4, Oxidative stress, Denervation, UPS, Autophagy, HDAC inhibitors, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background Denervation triggers numerous molecular responses in skeletal muscle, including the activation of catabolic pathways and oxidative stress, leading to progressive muscle atrophy. Histone deacetylase 4 (HDAC4) mediates skeletal muscle response to denervation, suggesting the use of HDAC inhibitors as a therapeutic approach to neurogenic muscle atrophy. However, the effects of HDAC4 inhibition in skeletal muscle in response to long-term denervation have not been described yet. Methods To further study HDAC4 functions in response to denervation, we analyzed mutant mice in which HDAC4 is specifically deleted in skeletal muscle. Results After an initial phase of resistance to neurogenic muscle atrophy, skeletal muscle with a deletion of HDAC4 lost structural integrity after 4 weeks of denervation. Deletion of HDAC4 impaired the activation of the ubiquitin-proteasome system, delayed the autophagic response, and dampened the OS response in skeletal muscle. Inhibition of the ubiquitin-proteasome system or the autophagic response, if on the one hand, conferred resistance to neurogenic muscle atrophy; on the other hand, induced loss of muscle integrity and inflammation in mice lacking HDAC4 in skeletal muscle. Moreover, treatment with the antioxidant drug Trolox prevented loss of muscle integrity and inflammation in in mice lacking HDAC4 in skeletal muscle, despite the resistance to neurogenic muscle atrophy. Conclusions These results reveal new functions of HDAC4 in mediating skeletal muscle response to denervation and lead us to propose the combined use of HDAC inhibitors and antioxidant drugs to treat neurogenic muscle atrophy.

Published
2018
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103. Near-fatal asthma responsive to mepolizumab after failure of omalizumab and bronchial thermoplasty

Author

Menzella F, Galeone C, Lusuardi M, Simonazzi A, Castagnetti C, Ruggiero P, and Facciolongo N

Subjects
Severe asthma, omalizumab, bronchial thermoplasty, mepolizumab, exacerbation, eosinophilia, Therapeutics. Pharmacology, RM1-950
Abstract

Francesco Menzella,1 Carla Galeone,1 Mirco Lusuardi,2 Anna Simonazzi,1 Claudia Castagnetti,1 Patrizia Ruggiero,1 Nicola Facciolongo1 1Department of Medical Specialties, Pneumology Unit, Arcispedale Santa Maria Nuova – IRCCS, Azienda USL di Reggio Emilia, Reggio Emilia, 2Unit of Respiratory Rehabilitation, Azienda USL di Reggio Emilia, S. Sebastiano Hospital, Correggio, Italy Abstract: Severe asthma affects between 5% and 10% of patients with asthma worldwide and requires best standard therapies at maximal doses, but there is a subgroup of patients refractory to all treatments. We share a case report of a 53-year-old woman with a history of severe allergic asthma that progressively worsened over the years despite the best therapy. She had been hospitalized 35 times, including nine admissions to the respiratory intensive care unit due to severe exacerbations. To rule out other possible diagnoses, several investigations were performed, such as computed tomography scan of the chest and neck, fiberoptic laryngoscopy, antineutrophil cytoplasmic antibodies, and complete blood cell count. The patient was first treated with omalizumab, which was completely ineffective, and then with bronchial thermoplasty (BT), again without clinical benefit. The situation remained critical for about 3 months during the last hospitalization, but in February 2017, the Italian Medicines Agency approved the treatment of severe refractory eosinophilic asthma with mepolizumab (Nucala®). Given a blood eosinophil count of 300 cells/µL, our patient was started on 100 mg mepolizumab treatment. After the second administration, symptoms improved progressively, with a reduction in the number and severity of exacerbations, so the patient could finally be discharged from hospital. At follow-up, it was possible to reduce and then suspend oral corticosteroids by continuing only with inhaled corticosteroids/long-acting beta-agonists and montelukast. No further asthmatic exacerbations occurred; symptom control and quality of life improved significantly. To our knowledge, this is the first case of a patient unresponsive to omalizumab and BT but with excellent clinical response to mepolizumab. She is also the first patient to be treated with an anti-IL5 agent in Italy in a real-life clinical setting. The availability of new effective biological agents will allow many patients to resume as normal a life as possible, with a positive outcome also from a social and economic point of view. Keywords: severe asthma, omalizumab, bronchial thermoplasty, mepolizumab, exacerbation, eosinophilia

Published
2017

104. Out of the Crisis. A radical change of strategy for the Eurozone

Author

Andrea Ginzburg and Annamaria Simonazzi

Subjects
eurocrisis, southern europe, germany, competitiveness, industrial policy, Economics as a science, HB71-74
Abstract

The paper argues that the crisis, mistakenly interpreted as a standard fiscal/balance of payments problem, was generated by the incomplete nature of the European institutions and a disregard for the consequences of differences in the stages of development of the member countries. The ideological pre-conception that markets are self-equilibrating through price competition has been used to justify disastrous internal devaluation policies in the belief that an austerity regime associated with institutions close to those assumed to prevail in 'core' countries would create the 'right' environment for resuming growth in the periphery. An analysis of the main phases of the development of European countries since the second post-war period provides evidence of wide differences in the productive structures of the countries of the centre and the southern periphery of Europe at the start of the Europeanization process. These differences entailed an asymmetric capacity of countries at differing levels of development to adjust to external shocks. This longer-term perspective helps us better to assess the limitations of the two alternatives that have been suggested to steer the EZ economy out of its present quagmire: internal devaluation (wage flexibility) in the deficit (Southern European) countries, or expansion of internal demand in 'core' countries (Germany). Both measures, it is argued, do not go to the root of the development and debt sustainability problems of Southern European countries, which continue to lack a sufficiently broad and differentiated productive structure. Given the differences in the levels of development of the various EU countries and their varying capacities to cope with change, fiscal policy should be assigned two complementary targets: the role of actively promoting — through investment —the removal of development bottlenecks and the renewal of the productive base, and a redistributive and compensative function. This new strategy entails the assignment of a strategic importance to investment guidance by the State through industrial policies geared to diversifying, innovating and strengthening the economic structures of peripheral countries. The paper concludes that this change of strategy is even more important today, since the crisis marks another important structural break in world trade, similar to those of the 1970s and the first decade of the new millennium.

Published
2017
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106. Figure 2 from: Gianguzzi L, Guarino R, Bazan G, Di Pietro R, Acosta ATR, Bajona E, Bolliger P, Bonomi C, Camuffo A, Console C, Fascetti S, Fortini P, Frattaroli A, Mei G, Mondello F, Olivari S, Rizzieri M, Rosati L, Sarmati S, Scuderi L, Simonazzi M, Spampinato G, Viegi L, Stinca A (2023) Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy). Italian Botanist 16: 1-57. https://doi.org/10.3897/italianbotanist.16.103989

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

Published
2023
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107. Figure 9 from: Gianguzzi L, Guarino R, Bazan G, Di Pietro R, Acosta ATR, Bajona E, Bolliger P, Bonomi C, Camuffo A, Console C, Fascetti S, Fortini P, Frattaroli A, Mei G, Mondello F, Olivari S, Rizzieri M, Rosati L, Sarmati S, Scuderi L, Simonazzi M, Spampinato G, Viegi L, Stinca A (2023) Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy). Italian Botanist 16: 1-57. https://doi.org/10.3897/italianbotanist.16.103989

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

Published
2023
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108. Figure 10 from: Gianguzzi L, Guarino R, Bazan G, Di Pietro R, Acosta ATR, Bajona E, Bolliger P, Bonomi C, Camuffo A, Console C, Fascetti S, Fortini P, Frattaroli A, Mei G, Mondello F, Olivari S, Rizzieri M, Rosati L, Sarmati S, Scuderi L, Simonazzi M, Spampinato G, Viegi L, Stinca A (2023) Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy). Italian Botanist 16: 1-57. https://doi.org/10.3897/italianbotanist.16.103989

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

Published
2023
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109. Figure 4 from: Gianguzzi L, Guarino R, Bazan G, Di Pietro R, Acosta ATR, Bajona E, Bolliger P, Bonomi C, Camuffo A, Console C, Fascetti S, Fortini P, Frattaroli A, Mei G, Mondello F, Olivari S, Rizzieri M, Rosati L, Sarmati S, Scuderi L, Simonazzi M, Spampinato G, Viegi L, Stinca A (2023) Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy). Italian Botanist 16: 1-57. https://doi.org/10.3897/italianbotanist.16.103989

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

Published
2023
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110. Figure 5 from: Gianguzzi L, Guarino R, Bazan G, Di Pietro R, Acosta ATR, Bajona E, Bolliger P, Bonomi C, Camuffo A, Console C, Fascetti S, Fortini P, Frattaroli A, Mei G, Mondello F, Olivari S, Rizzieri M, Rosati L, Sarmati S, Scuderi L, Simonazzi M, Spampinato G, Viegi L, Stinca A (2023) Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy). Italian Botanist 16: 1-57. https://doi.org/10.3897/italianbotanist.16.103989

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

Published
2023
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111. Figure 6 from: Gianguzzi L, Guarino R, Bazan G, Di Pietro R, Acosta ATR, Bajona E, Bolliger P, Bonomi C, Camuffo A, Console C, Fascetti S, Fortini P, Frattaroli A, Mei G, Mondello F, Olivari S, Rizzieri M, Rosati L, Sarmati S, Scuderi L, Simonazzi M, Spampinato G, Viegi L, Stinca A (2023) Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy). Italian Botanist 16: 1-57. https://doi.org/10.3897/italianbotanist.16.103989

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

Published
2023
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112. Supplementary material 4 from: Gianguzzi L, Guarino R, Bazan G, Di Pietro R, Acosta ATR, Bajona E, Bolliger P, Bonomi C, Camuffo A, Console C, Fascetti S, Fortini P, Frattaroli A, Mei G, Mondello F, Olivari S, Rizzieri M, Rosati L, Sarmati S, Scuderi L, Simonazzi M, Spampinato G, Viegi L, Stinca A (2023) Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy). Italian Botanist 16: 1-57. https://doi.org/10.3897/italianbotanist.16.103989

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

Published
2023
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113. Figure 7 from: Gianguzzi L, Guarino R, Bazan G, Di Pietro R, Acosta ATR, Bajona E, Bolliger P, Bonomi C, Camuffo A, Console C, Fascetti S, Fortini P, Frattaroli A, Mei G, Mondello F, Olivari S, Rizzieri M, Rosati L, Sarmati S, Scuderi L, Simonazzi M, Spampinato G, Viegi L, Stinca A (2023) Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy). Italian Botanist 16: 1-57. https://doi.org/10.3897/italianbotanist.16.103989

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

Published
2023
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114. Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy)

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

Published
2023
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115. Supplementary material 2 from: Gianguzzi L, Guarino R, Bazan G, Di Pietro R, Acosta ATR, Bajona E, Bolliger P, Bonomi C, Camuffo A, Console C, Fascetti S, Fortini P, Frattaroli A, Mei G, Mondello F, Olivari S, Rizzieri M, Rosati L, Sarmati S, Scuderi L, Simonazzi M, Spampinato G, Viegi L, Stinca A (2023) Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy). Italian Botanist 16: 1-57. https://doi.org/10.3897/italianbotanist.16.103989

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

Published
2023
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116. Supplementary material 1 from: Gianguzzi L, Guarino R, Bazan G, Di Pietro R, Acosta ATR, Bajona E, Bolliger P, Bonomi C, Camuffo A, Console C, Fascetti S, Fortini P, Frattaroli A, Mei G, Mondello F, Olivari S, Rizzieri M, Rosati L, Sarmati S, Scuderi L, Simonazzi M, Spampinato G, Viegi L, Stinca A (2023) Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy). Italian Botanist 16: 1-57. https://doi.org/10.3897/italianbotanist.16.103989

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

Published
2023
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117. Figure 8 from: Gianguzzi L, Guarino R, Bazan G, Di Pietro R, Acosta ATR, Bajona E, Bolliger P, Bonomi C, Camuffo A, Console C, Fascetti S, Fortini P, Frattaroli A, Mei G, Mondello F, Olivari S, Rizzieri M, Rosati L, Sarmati S, Scuderi L, Simonazzi M, Spampinato G, Viegi L, Stinca A (2023) Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy). Italian Botanist 16: 1-57. https://doi.org/10.3897/italianbotanist.16.103989

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

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2023
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118. Figure 3 from: Gianguzzi L, Guarino R, Bazan G, Di Pietro R, Acosta ATR, Bajona E, Bolliger P, Bonomi C, Camuffo A, Console C, Fascetti S, Fortini P, Frattaroli A, Mei G, Mondello F, Olivari S, Rizzieri M, Rosati L, Sarmati S, Scuderi L, Simonazzi M, Spampinato G, Viegi L, Stinca A (2023) Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy). Italian Botanist 16: 1-57. https://doi.org/10.3897/italianbotanist.16.103989

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

Published
2023
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119. Supplementary material 5 from: Gianguzzi L, Guarino R, Bazan G, Di Pietro R, Acosta ATR, Bajona E, Bolliger P, Bonomi C, Camuffo A, Console C, Fascetti S, Fortini P, Frattaroli A, Mei G, Mondello F, Olivari S, Rizzieri M, Rosati L, Sarmati S, Scuderi L, Simonazzi M, Spampinato G, Viegi L, Stinca A (2023) Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy). Italian Botanist 16: 1-57. https://doi.org/10.3897/italianbotanist.16.103989

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

Published
2023
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120. Supplementary material 3 from: Gianguzzi L, Guarino R, Bazan G, Di Pietro R, Acosta ATR, Bajona E, Bolliger P, Bonomi C, Camuffo A, Console C, Fascetti S, Fortini P, Frattaroli A, Mei G, Mondello F, Olivari S, Rizzieri M, Rosati L, Sarmati S, Scuderi L, Simonazzi M, Spampinato G, Viegi L, Stinca A (2023) Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy). Italian Botanist 16: 1-57. https://doi.org/10.3897/italianbotanist.16.103989

Author

Gianguzzi, Lorenzo, primary, Guarino, Riccardo, additional, Bazan, Giuseppe, additional, Di Pietro, Romeo, additional, Acosta, Alicia Teresa Rosario, additional, Bajona, Enrico, additional, Bolliger, Peter, additional, Bonomi, Costantino, additional, Camuffo, Adriano, additional, Console, Carlo, additional, Fascetti, Simonetta, additional, Fortini, Paola, additional, Frattaroli, Annarita, additional, Mei, Giacomo, additional, Mondello, Fabio, additional, Olivari, Silvia, additional, Rizzieri, Masin, additional, Rosati, Leonardo, additional, Sarmati, Simona, additional, Scuderi, Leonardo, additional, Simonazzi, Marco, additional, Spampinato, Giovanni, additional, Viegi, Lucia, additional, and Stinca, Adriano, additional

Published
2023
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127. PREGNANCY LOSS IN WOMEN WITH HIV IS NOT ASSOCIATED WITH HIV MARKERS: DATA FROM A NATIONAL STUDY IN ITALY, 2001-2018

Author

Marco Floridia, Giulia Masuelli, Beatrice Tassis, Enrica Tamburrini, Valeria Savasi, Matilde Sansone, Arsenio Spinillo, Giuseppina Liuzzi, Anna Degli Antoni, Serena Dalzero, Laura Franceschetti, Giuliana Simonazzi, Gianpaolo Maso, Daniela Francisci, Carmela Pinnetti, and Marina Ravizza

Subjects
HIV, miscarriage, stillbirth, CD4 cell count, pregnancy loss., Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Background: There is limited information on pregnancy loss in women with HIV, and it is still debate whether HIV-related markers may play a role. Objectives: To explore potential risk factors for pregnancy loss in women with HIV, with particular reference to modifiable risk factors and markers of HIV disease. Methods: Multicenter observational study of HIV-positive pregnant women. The main outcome measure was pregnancy loss, including both miscarriage (

Published
2019
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130. European Union’s Structural Vulnerability in a Changing Geopolitical Environment

Author

Simonazzi,Annamaria

Subjects
regional disparity, disparité régionale, Union économique et monétaire, relations centre-périphérie, disparidade regional, center-periphery relations, politique industrielle, integração europeia, relações centro-periferia, União Económica e Monetária, intégration européenne, Economic and Monetary Union, European integration, política industrial, industrial policy
Abstract

After several decades of economic integration and enlargement, divergence has been increasing in the European Union (EU), with weaker member states and regions falling behind their stronger counterparts. This paper argues that the structural causes of this increasing divide are explained in terms of the divergent trajectories of interdependent economies with different productive capabilities. In the process of European integration, the Southern peripheral countries were exposed to macroeconomic policies and shocks that, although apparently neutral, generated different effects and ever increasing regional disparities. Since the formation of the EU’s Economic and Monetary Union in 1992, events representing important milestones in the process of divergence include China’s accession to the World Trade Organization, the eastward orientation of German industry, and the 2008 financial and sovereign debt crises and the ensuing austerity. In the final part, the paper evaluates whether new divides are likely to emerge in the new global context triggered now by the COVID-19 pandemic and the Russia-Ukraine war. Após várias décadas de integração e alargamento económico, as divergências têm vindo a aumentar na União Europeia, com as regiões e os Estados-Membros mais fracos a ficarem atrás dos seus homólogos mais fortes. O artigo argumenta que as causas estruturais desta divisão crescente são explicadas em termos de trajetórias divergentes de economias interdependentes com diferentes capacidades produtivas. No processo de integração europeia, os países periféricos do Sul foram expostos a políticas e choques macroeconómicos que, embora aparentemente neutros, geraram efeitos diversos e crescentes disparidades regionais. Desde a formação da União Económica e Monetária em 1992, alguns acontecimentos representaram marcos importantes no processo de divergência, como a adesão da China à Organização Mundial do Comércio, a orientação da indústria alemã para Leste, a crise financeira e da dívida soberana de 2008 e a subsequente austeridade. Na parte final, o artigo avalia se é provável que novas divisões surjam no novo contexto global desencadeado desta vez pela pandemia de COVID-19 e pela guerra Rússia-Ucrânia. Après plusieurs décennies d’intégration économique et d’élargissement, les divergences se sont creusées au sein de l’Union européenne, les régions et les États-membres les plus faibles accusant un retard par rapport à leurs homologues plus forts. L’article soutient que les causes structurelles de cette fracture croissante s’expliquent en termes de trajectoires divergentes d’économies interdépendantes aux capacités productives différentes. Dans le processus d’intégration européenne, les pays périphériques du Sud ont été exposés à des politiques et à des chocs macroéconomiques qui, bien qu’apparemment neutres, ont généré des effets divers et des disparités régionales croissantes. Depuis la formation de l’Union économique et monétaire en 1992, certains évènements représentent des jalons importants dans le processus de divergence, comme l’adhésion de la Chine à l’Organisation mondiale du commerce, l’orientation de l’industrie allemande vers l’Est, la crise financière et de la dette souveraine de 2008 et l’austérité qui s’en est suivie. Dans la dernière partie, l’article évalue si de nouvelles divisions sont susceptibles d’émerger dans le nouveau contexte mondial déclenché par la pandémie de COVID-19 et la guerre Russie-Ukraine.

Published
2023

131. Design Procedure Based on Maximum Efficiency for Wireless Power Transfer Battery Chargers with Lightweight Vehicle Assembly

Author

Mattia Simonazzi, Alessandro Campanini, Leonardo Sandrolini, Claudio Rossi, Simonazzi M., Campanini A., Sandrolini L., and Rossi C.

Subjects
Technology, Control and Optimization, battery charger, wireless power transfer, inductive power transfer, design procedure, Renewable Energy, Sustainability and the Environment, Energy Engineering and Power Technology, Electrical and Electronic Engineering, Engineering (miscellaneous), Energy (miscellaneous)
Abstract

This paper analyzes two different design procedures for a series-parallel compensated WPT battery charger, based on different definitions of the operating resonant frequency in the condition of maximum link efficiency. The behaviour of the voltage gain magnitude and the input impedance angle of the resulting WPT links is studied for different loads and coupling coefficients. The design algorithms are supported by analytical formulas derived from an exact circuit analysis of the WPT link, avoiding approximations as far as possible. To support the theoretical approach a case study is proposed, in which both design procedures are implemented considering specifications in line with the actual automotive standards. To conclude, a characterization of the efficiency in both cases is derived.

Published
2022

132. A New Predictive Technology for Perinatal Stem Cell Isolation Suited for Cell Therapy Approaches

Author

Silvia Zia, Giulia Martini, Valeria Pizzuti, Alessia Maggio, Giuliana Simonazzi, Pierluigi Reschiglian, Laura Bonsi, Francesco Alviano, Barbara Roda, and Andrea Zattoni

Subjects
fetal stem cells, amniotic epithelial cells, isolation protocol, quality control, label-free sorting, diagnostic tool, Mechanical engineering and machinery, TJ1-1570
Abstract

The use of stem cells for regenerative applications and immunomodulatory effect is increasing. Amniotic epithelial cells (AECs) possess embryonic-like proliferation ability and multipotent differentiation potential. Despite the simple isolation procedure, inter-individual variability and different isolation steps can cause differences in isolation yield and cell proliferation ability, compromising reproducibility observations among centers and further applications. We investigated the use of a new technology as a diagnostic tool for quality control on stem cell isolation. The instrument label-free separates cells based on their physical characteristics and, thanks to a micro-camera, generates a live fractogram, the fingerprint of the sample. Eight amniotic membranes were processed by trypsin enzymatic treatment and immediately analysed. Two types of profile were generated: a monomodal and a bimodal curve. The first one represented the unsuccessful isolation with all recovered cell not attaching to the plate; while for the second type, the isolation process was successful, but we discovered that only cells in the second peak were alive and resulted adherent. We optimized a Quality Control (QC) method to define the success of AEC isolation using the fractogram generated. This predictive outcome is an interesting tool for laboratories and cell banks that isolate and cryopreserve fetal annex stem cells for research and future clinical applications.

Published
2021
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135. Analysis and design considerations of resonator arrays for inductive power transfer systems

Author

Sandrolini, Leonardo, Simonazzi, Mattia <1995>, Sandrolini, Leonardo, and Simonazzi, Mattia <1995>

Abstract

In the frame of inductive power transfer (IPT) systems, arrays of magnetically coupled resonators have received increasing attention as they are cheap and versatile due to their simple structure. They consist of magnetically coupled coils, which resonate with their self-capacitance or lumped capacitive networks. Of great industrial interest are planar resonator arrays used to power a receiver that can be placed at any position above the array. A thorough circuit analysis has been carried out, first starting from traditional two-coil IPT devices. Then, resonator arrays have been introduced, with particular attention to the case of arrays with a receiver. To evaluate the system performance, a circuit model based on original analytical formulas has been developed and experimentally validated. The results of the analysis also led to the definition of a new doubly-fed array configuration with a receiver that can be placed above it at any position. A suitable control strategy aimed at maximising the transmitted power and the efficiency has been also proposed. The study of the array currents has been carried out resorting to the theory of magneto-inductive waves, allowing useful insight to be highlighted. The analysis has been completed with a numerical and experimental study on the magnetic field distribution originating from the array. Furthermore, an application of the resonator array as a position sensor has been investigated. The position of the receiver is estimated through the measurement of the array input impedance, for which an original analytical expression has been also obtained. The application of this sensing technique in an automotive dynamic IPT system has been discussed. The thesis concludes with an evaluation of the possible applications of two-dimensional resonator arrays in IPT systems. These devices can be used to improve system efficiency and transmitted power, as well as for magnetic field shielding.

Published
2023

136. Role of second trimester ultrasound in prediction of newborns neurologic damage after maternal Cytomegalovirus infection

Author

Simonazzi, Giuliana, Della Gatta, Anna Nunzia <1989>, Simonazzi, Giuliana, and Della Gatta, Anna Nunzia <1989>

Abstract

Objective To find a correlation between cerebral symptoms at birth and abnormalities found at anomaly scan, through the analysis of sensitivity of the anomaly scan in the prediction of severe CMV neonatal disease. Methods - Design, Setting, Population This was a retrospective collection of all cases of primary congenital CMV infection reported in our unit (Obstetrics and Perinatal Medicine, Policlinico di S Orsola, IRCSS, Bologna) over a period of 9 years (2013–2022). Only cases of fetal infection following confirmed maternal primary infection in the first trimester (MPI) and newborns with confirmed CMV infection on blood/saliva or urine were included. Results Between 2014 and 2022, 69 fetuses had an antenatal diagnosis of primary CMV infection. The infection occurred after MPI in the first, second, and third trimester in 63.7% (43/69), 27.5% (19/69), and 10% (7/69) of cases, respectively. Second-trimester assessment by anomaly scan was abnormal in 10/69 (15%) fetuses: 5/69 (7%) had an extracerebral STA and 5/69 (7%) had a cerebral STA. Normal anomaly scan was found in 59/69 (86%) fetuses. When looking at all fetuses infected in the first trimester, 12.5% (5/40) underwent TOP and 45% (18/40) had symptoms at birth. A mean follow-up of 22.4 months (range 12–48 months) was available for 68/69 (99%) live born neonates. Conclusion Anomaly scan results to have a predictive positive value of 67% fetuses infected in the first trimester. Serial assessment by ultrasound is necessary to predict the risk of sequelae occurring in 35% following fetal infection in the first trimester of pregnancy. This combined evaluation by US and trimester of infection should be useful when counselling on the prognosis of cCMV infection.

Published
2023

137. Toxic cyanobacteria in water intended for drinking purpose: improvement of cells and toxins’ analyses and of treatments for their removal

Author

Pistocchi, Rossella, Simonazzi, Mara <1992>, Pistocchi, Rossella, and Simonazzi, Mara <1992>

Abstract

Massive proliferations of cyanobacteria in freshwaters have recently increased, causing ecological and economic losses. Their ever-increasing presence in water sources destined to potabilization has become a major threat for public health, since several species can produce harmful toxins (cyanotoxin). Therefore, additional specific measures to improve management and treatment of drinking water(s) are required. The PhD thesis investigates toxic cyanobacteria in drinking waters with a special focus on Emilia-Romagna (Italy), throughout three separated chapters, each with different specific objectives. The first chapter aims at improving the fast monitoring of cyanobacteria in drinking water, which was investigated by testing different models of multi-wavelength spectrofluorometers. Inter-laboratories calibrations were conducted using mono-specific cultures and field samples, and both the feasibility and the technical limitations of such tools were illustrated. The second chapter evaluates the effectiveness of drinking water treatments in removing cyanobacterial cells and toxins. Two chlorinated oxidants (sodium hypochlorite and chlorine dioxide) already in use for pre-oxidation during water potabilization, were tested on cultures of the toxic cyanobacterium Microcystis aeruginosa posing a specific focus on toxin removal and revealing that pre-oxidation can cause the release of toxins and unknown metabolites. Innovative treatments based on non-thermal plasma were also tested, observing an effective and rapid inactivation of cyanobacterial cells. The third chapter presents a study on a cyanobacterium isolated from a drinking water reservoir of Emilia-Romagna and investigated by combining biological, chemical, and genomic methods. Although the strain did not produce any known cyanotoxin, high toxicity of water-extract was observed in bioassays and potential implications for drinking water were discussed. Overall, the PhD thesis offers new insights into toxic cyanobacteri

Published
2023

138. Dieci lezioni di sociologia economica

Author

Augusto Cocorullo (ORCID:0000-0002-9584-776X), Andrea Bottalico, Augusto Cocorullo, Marco Ferracci, Enrica Morlicchio, Francesco Pirone, Angelo Salento, Emanuele Scognamiglio, Anna Maria Simonazzi, Morlicchio, Enrica, Cocorullo, Augusto, Augusto Cocorullo (ORCID:0000-0002-9584-776X), Andrea Bottalico, Augusto Cocorullo, Marco Ferracci, Enrica Morlicchio, Francesco Pirone, Angelo Salento, Emanuele Scognamiglio, Anna Maria Simonazzi, Morlicchio, Enrica, and Cocorullo, Augusto

Abstract

Il libro avvicina allo studio sociologico dei fenomeni economici, fornendo le categorie analitiche e gli strumenti teorici e metodologici di base che ruotano intorno alla distinzione polanyiana tra concezione formale e sostanziale.

Published
2023

139. Food-related aversion in a female sample of people with anorexia nervosa: Cognitive-behavioural correlates, somatic and subjective anxiety, and early experiences

Author

Simonazzi, C., Natali, L., Valmaggia, L., Rowlands, K., Meregalli, V., Rabarbari, Elisa, De Luca Comandini, A., Favaro, A., Fontana, F., Treasure, J., Cardi, V., Rabarbari E. (ORCID:0009-0008-3724-7337), Simonazzi, C., Natali, L., Valmaggia, L., Rowlands, K., Meregalli, V., Rabarbari, Elisa, De Luca Comandini, A., Favaro, A., Fontana, F., Treasure, J., Cardi, V., and Rabarbari E. (ORCID:0009-0008-3724-7337)

Abstract

Objective: Food-related anxiety and avoidance are key features of anorexia nervosa, and among the most arduous maintaining processes to address in treatment. This study gathered information on the behavioural and cognitive correlates of food-related anxiety, including their associations with early experiences of aversive learning related to food, and more general anxiety. Methods: One-hundred and forty-four patients with anorexia nervosa were recruited from clinical services in Italy. They completed online questionnaires to assess food-related anxiety, eating disorder psychopathology, eating disorder safety behaviours and threat cognitions, early experience of aversive learning related to food, and somatic anxiety. Results: Experiences of food-related aversive learning were recalled by the majority of the sample (87.86%), with negative psychological consequences following eating being the most often reported (75%). Safety behaviours and threat cognitions related to the consequences of eating were also reported (14.29%–87.86%, and 36.43–90% respectively, depending on the behaviour/cognition). Eating disorder psychopathology was predicted by both somatic anxiety and negative psychological consequences following eating, whereas self-reported food anxiety was only predicted by somatic anxiety. Conclusion: Findings validate an anxiety-based model of anorexia nervosa which establishes the role of safety behaviours, threat cognitions, early aversive learning experiences, and anxiety in the psychopathology of the illness. Exposure-based interventions have the potential to target these factors, and inhibit food-related fear.

Published
2023

140. Notulae to the Italian alien vascular flora: 15

Author

Galasso, Gabriele, primary, Domina, Gianniantonio, additional, Argenti, Carlo, additional, Bajona, Enrico, additional, Banfi, Enrico, additional, Barberis, Davide, additional, Barone, Giulio, additional, Bartolucci, Fabrizio, additional, Biscotti, Nello, additional, Bonali, Fabrizio, additional, Bonifazio, Chiara, additional, Bonsanto, Daniele, additional, Buldrini, Fabrizio, additional, Cannucci, Silvia, additional, Cozzolino, Alessia, additional, De Natale, Antonino, additional, Del Guacchio, Emanuele, additional, Di Gristina, Emilio, additional, Fiaschi, Tiberio, additional, Lallai, Andrea, additional, Lonati, Michele, additional, Lucchese, Fernando, additional, Lupoletti, Jacopo, additional, Marchi, Niccolò, additional, Motti, Riccardo, additional, Nota, Ginevra, additional, Pica, Antonio, additional, Pittarello, Marco, additional, Potenza, Giovanna, additional, Ratini, Giuseppe, additional, Rota, Franco, additional, Santi, Francesco, additional, Santini, Claudio, additional, Sarigu, Marco, additional, Selvaggi, Alberto, additional, Simonazzi, Marco, additional, Tardella, Federico M., additional, Tripi, Silvia, additional, Vetromile, Roberto, additional, and Lastrucci, Lorenzo, additional

Published
2023
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141. Supplementary material 1 from: Galasso G, Domina G, Argenti C, Bajona E, Banfi E, Barberis D, Barone G, Bartolucci F, Biscotti N, Bonali F, Bonifazio C, Bonsanto D, Buldrini F, Cannucci S, Cozzolino A, De Natale A, Del Guacchio E, Di Gristina E, Fiaschi T, Lallai A, Lonati M, Lucchese F, Lupoletti J, Marchi N, Motti R, Nota G, Pica A, Pittarello M, Potenza G, Ratini G, Rota F, Santi F, Santini C, Sarigu M, Selvaggi A, Simonazzi M, Tardella FM, Tripi S, Vetromile R, Lastrucci L (2023) Notulae to the Italian alien vascular flora: 15. Italian Botanist 15: 77-89. https://doi.org/10.3897/italianbotanist.15.105794

Author

Galasso, Gabriele, primary, Domina, Gianniantonio, additional, Argenti, Carlo, additional, Bajona, Enrico, additional, Banfi, Enrico, additional, Barberis, Davide, additional, Barone, Giulio, additional, Bartolucci, Fabrizio, additional, Biscotti, Nello, additional, Bonali, Fabrizio, additional, Bonifazio, Chiara, additional, Bonsanto, Daniele, additional, Buldrini, Fabrizio, additional, Cannucci, Silvia, additional, Cozzolino, Alessia, additional, De Natale, Antonino, additional, Del Guacchio, Emanuele, additional, Di Gristina, Emilio, additional, Fiaschi, Tiberio, additional, Lallai, Andrea, additional, Lonati, Michele, additional, Lucchese, Fernando, additional, Lupoletti, Jacopo, additional, Marchi, Niccolò, additional, Motti, Riccardo, additional, Nota, Ginevra, additional, Pica, Antonio, additional, Pittarello, Marco, additional, Potenza, Giovanna, additional, Ratini, Giuseppe, additional, Rota, Franco, additional, Santi, Francesco, additional, Santini, Claudio, additional, Sarigu, Marco, additional, Selvaggi, Alberto, additional, Simonazzi, Marco, additional, Tardella, Federico M., additional, Tripi, Silvia, additional, Vetromile, Roberto, additional, and Lastrucci, Lorenzo, additional

Published
2023
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143. Mode of delivery and peripartum outcome in women with heart disease according to the ESC guidelines: an Italian multicenter study

Author

Angeli, L., primary, Fieni, S., additional, Dall’Asta, A., additional, Ghi, T., additional, De Carolis, S., additional, Sorrenti, S., additional, Rizzo, F., additional, Della Gatta, A.N., additional, Simonazzi, G., additional, Pilu, G., additional, Benvenuti, M., additional, Luchi, C., additional, Simoncini, T., additional, Gaibazzi, N., additional, Niccoli, G., additional, Ardissino, D., additional, and Frusca, T., additional

Published
2023
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146. Pathophysiology of Hyperechogenic Bowel in Congenitally Human Cytomegalovirus Infected Fetuses

Author

Liliana Gabrielli, Maria P. Bonasoni, Angela Chiereghin, Giulia Piccirilli, Eva C. Borgatti, Giuliana Simonazzi, Nunzio C. M. Salfi, Ione Tamagnini, and Tiziana Lazzarotto

Subjects
CMV, hyperechogenic bowel, ganglion cells, bcl-2, meconium, Biology (General), QH301-705.5
Abstract

Hyperechogenic bowel (HB) is a nonspecific ultrasound finding that can be associated with human cytomegalovirus (CMV) congenital infection. In this study, we investigated HB pathophysiology in CMV-infected fetuses. We examined small and large intestine as well as pancreas in 8 fetuses at 22 weeks of gestation with congenital CMV infection. Ultrasound findings showed 4 fetuses with HB and 4 without. As negative group, 4 fetuses without CMV infection and without HB were studied. Immunohistochemistry for CMV, lymphocytic infiltrate, B-cell leukemia/lymphoma-2 (bcl-2), CD-117, cystic fibrosis transmembrane regulator (CFTR) were performed. HB fetuses showed multiple and sequential CMV-positive ganglion cells of Auerbach’s myenteric plexus. In the ganglia, bcl-2 was weakly expressed representing a reduced neuronal functionality. CD-117 revealed a regular distribution of Cajal cells, the pacemakers of intestinal contractility. Pancreas showed normal CFTR staining, indicating a preserved exocrine secretion, thus unlikely a contributory factor in HB. In CMV-infected fetuses without HB, CMV-positive cells were scatteredly found in ganglion cells and bcl-2 was strongly expressed. Intestinal CD-117 and pancreatic CFTR expression were similar to fetuses with HB. In conclusion, fetal CMV infection of the bowel may lead to peristalsis impairment (paralytic ileus) due to intestinal plexus involvement, which at ultrasound appeared as HB.

Published
2020
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147. Food-related aversion in a female sample of people with anorexia nervosa: Cognitive-behavioural correlates, somatic and subjective anxiety, and early experiences

Author

Carolina Simonazzi, Ludovica Natali, Lucia Valmaggia, Katie Rowlands, Valentina Meregalli, Elisa Rabarbari, Agnese De Luca Comandini, Angela Favaro, Francesca Fontana, Janet Treasure, and Valentina Cardi

Subjects
Feeding and Eating Disorders, Nutrition and Dietetics, Cognition, Italy, Eating disorders, Humans, Learning, Female, General Psychology, Threat, Conditioning, Vicarious
Abstract

Food-related anxiety and avoidance are key features of anorexia nervosa, and among the most arduous maintaining processes to address in treatment. This study gathered information on the behavioural and cognitive correlates of food-related anxiety, including their associations with early experiences of aversive learning related to food, and more general anxiety.One-hundred and forty-four patients with anorexia nervosa were recruited from clinical services in Italy. They completed online questionnaires to assess food-related anxiety, eating disorder psychopathology, eating disorder safety behaviours and threat cognitions, early experience of aversive learning related to food, and somatic anxiety.Experiences of food-related aversive learning were recalled by the majority of the sample (87.86%), with negative psychological consequences following eating being the most often reported (75%). Safety behaviours and threat cognitions related to the consequences of eating were also reported (14.29%-87.86%, and 36.43-90% respectively, depending on the behaviour/cognition). Eating disorder psychopathology was predicted by both somatic anxiety and negative psychological consequences following eating, whereas self-reported food anxiety was only predicted by somatic anxiety.Findings validate an anxiety-based model of anorexia nervosa which establishes the role of safety behaviours, threat cognitions, early aversive learning experiences, and anxiety in the psychopathology of the illness. Exposure-based interventions have the potential to target these factors, and inhibit food-related fear.

Published
2023

149. Characterization of Perinatal Stem Cell Spheroids for the Development of Cell Therapy Strategy

Author

Paris, Francesca, primary, Marrazzo, Pasquale, additional, Pizzuti, Valeria, additional, Marchionni, Cosetta, additional, Rossi, Maura, additional, Michelotti, Martina, additional, Petrovic, Biljana, additional, Ciani, Elisabetta, additional, Simonazzi, Giuliana, additional, Pession, Andrea, additional, Bonsi, Laura, additional, and Alviano, Francesco, additional

Published
2023
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