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103. The lipoprotein lipase serine 447 stop polymorphism is associated with altered serum carotenoid concentrations in the Stanislas Family Study.

Author

Herbeth, Bernard, Gueguen, Sonia, Leroy, Pierre, Siest, Gérard, Visvikis-Siest, Sophie, and Siest, Gérard

Abstract

Background: Carotenoids are mainly carried by lipoproteins in blood, however little is known about the influence of polymorphisms of apolipoproteins (apo), cholesterol ester transfer protein (CETP) and lipoprotein lipase (LPL) involved in serum lipid metabolism.Objective: We aimed to analyze whether serum concentrations of 5 carotenoids (lutein-zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, beta-carotene) are associated with common polymorphisms of Apo E, Apo B, Apo CIII, CETP, and LPL.Methods: Serum concentrations of lutein-zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, and beta-carotene were measured and polymorphisms of Apo E (cys112arg and arg158cys), Apo B (thr71ile), Apo CIII [C(-482)T, Apo CIII T(-455)C, Apo CIII C1100T, Apo CIII C3175G, Apo CIII T3206G], CETP (ile405val), and LPL (S447X) were determined in a sample of 447 children and adults drawn from the Stanislas Study.Results: After adjustment for age, sex, smoking, physical activity, oral contraceptive use, BMI, serum cholesterol and triglyceride concentrations, and fruit and vegetable intakes, carriers vs. non carriers of the lipoprotein lipase X447 allele had significant lower concentrations of lutein-zeaxanthin, beta-cryptoxanthin, alpha-carotene and beta-carotene; differences vs. S447S genotype being the largest for X447X: -18.8%, -50.5%, -54.8% and -47.1%, for the four carotenoid fractions, respectively. No significant association was noticed for lycopene concentration. None of the other tested polymorphisms was significantly related to the serum carotenoid concentrations.Conclusions: Our investigation for the first time demonstrates that LPL S447X polymorphism could alter serum concentrations of carotenoids in healthy individuals, independently of serum cholesterol and triglyceride concentration. These data indicate that genetic factors could be involved in the variability of carotenoid bioavailability and bioconversion. [ABSTRACT FROM AUTHOR]

Published
2007
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105. Influence of Genetic Variations on Levels of Inflammatory Markers of Healthy Subjects at Baseline and One Week after Clopidogrel Therapy; Results of a Preliminary Study

Author

Shahabi, Payman, primary, Siest, Gérard, additional, Herbeth, Bernard, additional, Lambert, Daniel, additional, Masson, Christine, additional, Hulot, Jean-Sébastien, additional, Bertil, Sébastien, additional, Gaussem, Pascale, additional, and Visvikis-Siest, Sophie, additional

Published
2013
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107. A prospective study on the prevalence of metabolic syndrome among healthy french families: two cardiovascular risk factors (HDL cholesterol and tumor necrosis factor-alpha) are revealed in the offspring of parents with metabolic syndrome.

Author

Maumus, Sandy, Marie, Bérangère, Siest, Gérard, Visvikis-Siest, Sophie, Marie, Bérangère, and Siest, Gérard

Subjects
METABOLISM, CHOLESTEROL, CARDIOVASCULAR diseases, DISEASE management, PHYSIOLOGY
Abstract

Objective: The purpose of this study was to estimate the longitudinal variation of prevalence of metabolic syndrome within French families and to observe biological parameters involved in cardiovascular disease among their offspring.Research Design and Methods: Three hundred seventy-one apparently healthy families (1,366 individuals) taken from the STANISLAS cohort were studied. The subjects were examined at two time points with a 5-year interval (t(0) and t(+5)). The crude prevalence of metabolic syndrome was assessed among parents according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP) definition.Results: The prevalence of metabolic syndrome was 5.9% in men and 2.1% in women at t(0), rising to 7.2 and 5.4% in men and women, respectively, at t(+5). Children of parents having metabolic syndrome showed higher levels of tumor necrosis factor-alpha (TNF-alpha), whereas their HDL cholesterol and apolipoprotein (apo) E concentrations were lower compared with those of age- and sex-matched control subjects (P Conclusions: Metabolic syndrome increases with age in supposedly healthy families from the STANISLAS cohort. In offspring of affected people, it seems to be predictive of higher values of TNF-alpha and low HDL cholesterol levels, which are two major cardiovascular factors. Therefore, in terms of prevention, it is important to identify and follow subjects with metabolic syndrome as well as their offspring, even in apparently healthy populations, to enable early disease management. [ABSTRACT FROM AUTHOR]

Published
2005
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111. A Genome-Wide Association Study Identifies rs2000999 as a Strong Genetic Determinant of Circulating Haptoglobin Levels

Author

Froguel, Philippe, primary, Ndiaye, Ndeye Coumba, additional, Bonnefond, Amélie, additional, Bouatia-Naji, Nabila, additional, Dechaume, Aurélie, additional, Siest, Gérard, additional, Herbeth, Bernard, additional, Falchi, Mario, additional, Bottolo, Leonardo, additional, Guéant-Rodriguez, Rosa-Maria, additional, Lecoeur, Cécile, additional, Langlois, Michel R., additional, Labrune, Yann, additional, Ruokonen, Aimo, additional, El Shamieh, Said, additional, Stathopoulou, Maria G., additional, Morandi, Anita, additional, Maffeis, Claudio, additional, Meyre, David, additional, Delanghe, Joris R., additional, Jacobson, Peter, additional, Sjöström, Lars, additional, Carlsson, Lena M. S., additional, Walley, Andrew, additional, Elliott, Paul, additional, Jarvelin, Marjo-Riita, additional, Dedoussis, George V., additional, and Visvikis-Siest, Sophie, additional

Published
2012
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122. Metrological sharp shooting for plasma proteins and peptides: The need for reference materials for accurate measurements in clinical proteomics and in vitro diagnostics to generate reliable results

Author

Vitzthum, Frank, primary, Siest, Gérard, additional, Bunk, David M., additional, Preckel, Tobias, additional, Wenz, Christian, additional, Hoerth, Patric, additional, Schulz‐Knappe, Peter, additional, Tammen, Harald, additional, Adamkiewicz, Juergen, additional, Merlini, Giampaolo, additional, and Anderson, N. Leigh, additional

Published
2007
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132. Changes in Serum Retinol, α-Tocopherol, Vitamin C, Carotenoids, Zinc and Selenium after Micronutrient Supplementation during Alcohol Rehabilitation

Author

Gueguen, Sonia, primary, Pirollet, Pascal, additional, Leroy, Pierre, additional, Guilland, Jean-Claude, additional, Arnaud, Josiane, additional, Paille, François, additional, Siest, Gérard, additional, Visvikis, Sophie, additional, Hercberg, Serge, additional, and Herbeth, Bernard, additional

Published
2003
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135. The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe

Author

Haddy, Nadia, primary, Bacquer, Dirk De, additional, Chemaly, Marianne Mansour, additional, Maurice, Mickaël, additional, Ehnholm, Christian, additional, Evans, Alun, additional, Sans, Susanna, additional, Martins, Maria do Carmo, additional, Backer, Guy De, additional, Siest, Gérard, additional, and Visvikis, Sophia, additional

Published
2002
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