202 results on '"Seok Chan, Kim"'
Search Results
102. Effect of nilotinib on bleomycin-induced acute lung injury and pulmonary fibrosis in mice
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Seok Chan Kim, Soon Suk Kwon, Tae-Jung Kim, Jin Woo Kim, Sang Haak Lee, Chin Kook Rhee, Kwan Hyoung Kim, Sook Young Lee, Young Kyoon Kim, and Hyung Kyu Yoon
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Pulmonary and Respiratory Medicine ,Male ,Time Factors ,medicine.drug_class ,Pulmonary Fibrosis ,Acute Lung Injury ,Blotting, Western ,Interleukin-1beta ,Pharmacology ,Lung injury ,Bleomycin ,Real-Time Polymerase Chain Reaction ,Tyrosine-kinase inhibitor ,Piperazines ,Transforming Growth Factor beta1 ,chemistry.chemical_compound ,Mice ,hemic and lymphatic diseases ,Pulmonary fibrosis ,medicine ,Biomarkers, Tumor ,Animals ,Kinase activity ,neoplasms ,Protein Kinase Inhibitors ,Antibiotics, Antineoplastic ,business.industry ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,Imatinib ,Protein-Tyrosine Kinases ,medicine.disease ,Imatinib mesylate ,Pyrimidines ,chemistry ,Nilotinib ,Gene Expression Regulation ,Basic Science Investigations ,Benzamides ,Imatinib Mesylate ,business ,medicine.drug - Abstract
Background: The tyrosine kinase inhibitor imatinib mesylate was developed as an inhibitor of the kinase activity of BCR-ABL. However, imatinib also has potent inhibitory activity against the platelet-derived growth factor receptor (PDGFR). Nilotinib is approved for treating patients with chronic myeloid leukemia showing resistance or intolerance to imatinib. Like imatinib, nilotinib selectively inhibits the tyrosine kinase activity of PDGFR. Objectives: We examined the effect of imatinib and nilotinib on acute lung injury and pulmonary fibrosis in a mouse model. Methods: Mice were treated by intratracheal instillation of bleomycin. Imatinib or nilotinib were administered by oral gavage. To study the early inflammatory and late fibrotic phases of lung injury, mice were sacrificed on days 3, 7, 14 and 21 after bleomycin instillation. Results: Histopathology showed that imatinib and nilotinib attenuated the extent of lung injury and fibrosis. The numbers of inflammatory cells and levels of IL-6, IL-1β and tumor necrosis factor-α were decreased in the imatinib and nilotinib groups on days 3 and 7. Imatinib and nilotinib therapy significantly reduced the levels of hydroxyproline on days 14 and 21, which was accompanied by decreased expression levels of transforming growth factor (TGF)-β1 and PDGFR-β. Imatinib and nilotinib also significantly reduced the expression levels of the genes for TGF-β1 and platelet-derived growth factor (PDGF). Imatinib and nilotinib treatment also significantly inhibited the PDGF-induced proliferation of lung fibroblasts in vitro. When imatinib or nilotinib was given 7 days after the instillation of bleomycin, only nilotinib attenuated pulmonary fibrosis. Conclusions: Imatinib and nilotinib attenuated bleomycin-induced acute lung injury and pulmonary fibrosis in mice. In a therapeutic model, nilotinib showed more potent antifibrotic effects than imatinib.
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- 2010
103. Factors affecting the accuracy of volume-oscillometric blood pressure measurement during partial pressurization of the wrist
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Kun-soo Shin, Youn Ho Kim, Jong Pal Kim, Seok Chan Kim, and Sang-Kon Bae
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Materials science ,Blood Pressure ,Sensitivity and Specificity ,law.invention ,Contact force ,Cabin pressurization ,law ,medicine.artery ,Oscillometry ,medicine ,Pressure ,Humans ,Radial artery ,Envelope (mathematics) ,Reproducibility of Results ,Blood Pressure Determination ,Mechanics ,Equipment Design ,equipment and supplies ,Pressure sensor ,Blood Pressure Monitors ,Equipment Failure Analysis ,Pressure measurement ,Blood pressure ,Volume (thermodynamics) ,Anesthesia ,Radial Artery ,Computer-Aided Design - Abstract
We compared the volume-oscillometric responses of the airbag pressure sensor and the contact force sensor across and along the radial artery on the wrist during partial pressurization by an airbag. Because of the anatomic structure and non-uniform pressurization pressure distribution, elongated and shifted oscillometric pressure waveform envelope variations are observed. For the contact force sensors directly above the radial artery, S-shaped pressurization curves can be seen possibly due to temporal softening of the radial artery stiffness at near zero transmural pressure. These differences in the shape of oscillometric envelope as well as pressurization curve may be the leading factors for inaccuracies of volume-oscillometric blood pressure measurement by partial pressurization method using an airbag.
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- 2009
104. Effects of tranilast and pentoxifylline in a mouse model of chronic asthma using house dust mite antigen
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Seung Joon Kim, Hyoung Kyu Yoon, Young Kyoon Kim, Sang Haak Lee, Jin Woo Kim, Soon Seog Kwon, Jin Sook Kim, Jung Mi Lee, Yong Hyun Kim, Sook Young Lee, Seok Chan Kim, Chi Hong Kim, and Joong Hyun Ahn
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Pulmonary and Respiratory Medicine ,Allergy ,Tranilast ,Fibrillar Collagens ,Pulmonary Fibrosis ,Inflammation ,Cell Count ,Pharmacology ,Immunoglobulin E ,Pentoxifylline ,Transforming Growth Factor beta1 ,Mice ,Anti-Allergic Agents ,medicine ,Leukocytes ,Immunology and Allergy ,Animals ,ortho-Aminobenzoates ,Antigens, Dermatophagoides ,Bronchioles ,House dust mite ,Mice, Inbred BALB C ,Hyperplasia ,Interleukin-13 ,biology ,business.industry ,Muscle, Smooth ,Smooth muscle hyperplasia ,medicine.disease ,biology.organism_classification ,Asthma ,respiratory tract diseases ,Specific Pathogen-Free Organisms ,Eosinophils ,Pediatrics, Perinatology and Child Health ,Interleukin 13 ,Immunology ,biology.protein ,Drug Therapy, Combination ,Female ,Goblet Cells ,medicine.symptom ,Bronchial Hyperreactivity ,business ,Bronchoalveolar Lavage Fluid ,medicine.drug - Abstract
Tranilast has been used in allergic diseases because of its inhibitory effect on mast cells; it also has an anti-fibrotic effect in several diseases. Pentoxifylline (PTX), a methylxanthine derivative, is a potent anti-inflammatory drug that is known to manifest its effect through the inhibition of Th1 cytokine, but with an uncertain effect on Th2 cytokine. Seven-week-old female BALB/c mice were studied as a chronic asthma model. The mice were challenged with house dust mite (HDM) antigen for 7 weeks. Each group of mice was given an intraperitoneal injection of tranilast, PTX, or tranilast plus PTX before antigen administration. In this mouse model of chronic asthma, tranilast, and PTX each had an inhibitory effect on airway remodeling as well as on airway hyperresponsiveness (AHR) and airway inflammation. The improved events of these drugs were related with the inhibition of the Th2 cytokine IL-13 and TGF-beta 1. Immunohistochemical analysis showed that decreases in the peribronchial trichrome stained area in each treatment group were associated with improvements in the peribronchial smooth muscle hyperplasia, collagen type I, and collagen type III deposition. These drugs could have potential beneficial effects on chronic asthma, especially with respect to airway remodeling.
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- 2009
105. Off-pump open pulmonary embolectomy for patients with major pulmonary embolism
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Pum Jun Kim, Jong Beom Kwon, Seok Whan Moon, Young Pil Wang, Keon Hyeon Jo, Seok Chan Kim, Si Young Choi, Young Jo Sa, Hae Ok Jung, and Jongho Lee
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Adult ,Male ,Embolectomy ,Pulmonary Artery ,law.invention ,Embolus ,law ,medicine.artery ,Cardiopulmonary bypass ,Medicine ,Humans ,Aged ,Retrospective Studies ,Cardiopulmonary Bypass ,business.industry ,Middle Aged ,medicine.disease ,Thrombosis ,Pulmonary embolism ,Radiography ,Catheter ,medicine.anatomical_structure ,Treatment Outcome ,Ventricle ,Anesthesia ,Pulmonary artery ,Surgery ,Female ,Cardiology and Cardiovascular Medicine ,business ,Airway ,Pulmonary Embolism - Abstract
Acute major pulmonary artery embolism (AMPE) requires rapid diagnosis and early intensive treatment to optimize patient outcomes. Most patients with AMPE and hemodynamic instability need open pulmonary embolectomy (OPE). We modified the technique of OPE to include a minimally invasive procedure without the use of cardiopulmonary bypass (CPB). From March 1988 to April 2006, we performed OPE on a total of 12 patients (21 sides) with AMPE. Seven patients (13 sides) underwent conventional OPE with CPB and 5 patients underwent off-pump OPE (OPPE), 4 (8 sides) with AMPE and 1 with catheter embolus with thrombosis. In patients who underwent conventional OPE, there was 1 hospital death in a patient with severe right ventricle dysfunction and 2 significant cases of airway bleeding. In patients who underwent OPPE, there was 1 case of minimal airway bleeding. Mean systolic pulmonary artery pressure in conventional OPE and OPPE patients, respectively, decreased from 50.3 +/- 14 mmHg and 35.4 +/- 6.6 mmHg pre-operatively to 41.7 +/- 20 and 28 +/- 3 mmHg postoperatively. During the long-term follow-up, there were 2 cancer-related deaths but no recurrence of PE. All surviving patients maintained functional class I (n = 10) or II (n = 1). Compared with conventional OPE, OPPE was effective for treating AMPE in our selected cases. Modification of conventional CPB and systemic full heparinization to minimal use of systemic heparinization without CPB may be helpful in treating selected patients with AMPE.
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- 2007
106. Intrathoracic aneurysm of the right subclavian artery presenting with hoarseness: a case report
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Seok Chan Kim, Myoung Sook Kim, Seung Soo Kim, Jongho Lee, Hong Gun Bin, and Jong Bum Keun
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medicine.medical_specialty ,medicine.medical_treatment ,Laryngoscopy ,Subclavian Artery ,Case Report ,Anastomosis ,Aneurysm ,medicine.artery ,medicine ,Humans ,cardiovascular diseases ,Thrombus ,Subclavian artery ,Aged ,Hoarseness ,medicine.diagnostic_test ,Aortic Aneurysm, Thoracic ,business.industry ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Radiography ,Median sternotomy ,Angiography ,cardiovascular system ,Female ,Radiology ,Chest radiograph ,business - Abstract
Intrathoracic segment of the subclavian artery is an unusual location for peripheral arterial aneurysms. They are normally caused by atherosclerosis, medial degeneration, trauma, and infection. We report a case of a patient with right subclavian artery aneurysm presenting with hoarseness. Chest radiograph demonstrated a superior mediastinal mass. Laryngoscopy showed a fixed right vocal cord. By chest computed tomography, magnetic resonance imaging, and angiography, preoperative diagnosis was established as a saccular aneurysm with afferent loop and efferent loop. Patient underwent complete resection of the aneurysm followed by end-to-end anastomosis via median sternotomy. Postoperative pathology was consistent with an atherosclerotic aneurysm filled with thrombus. After surgical operation, hoarseness is still continued.
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- 2005
107. Synthetic Study Toward a Protected 2-Deoxystreptamine
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Chan-Seong Cheong, Seok-Chan Kim, and Seung-Chul Lee
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Chemistry ,Stereochemistry ,Aminoglycoside ,General Chemistry ,General Medicine ,Gentamycins ,2-deoxystreptamine - Abstract
2-Deoxystreptamine (1) is a key component of aminoglycoside antibiotics such as Streptomycin, Neomycins, Kanamycins, Gentamycins and Sisomycins which are still clinically useful. The structure and configuration were established to be a 1,3-diamino-4,5,6-cyclohexanetriol with all-trans configuration. Despite numerous research interests in this area, only several chemical synthetic methods are known. Here we described the first synthetic approach of the protected 2-deoxystreptamine from myo-inositol.
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- 2005
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108. Intrapleural chemotherapy with cisplatin and cytarabine in the management of malignant pleural effusion
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Suk Young Park, Eun Hee Lee, Soyoung Shin, Seok Chan Kim, Jong Bum Kweon, Jongho Lee, Kee Won Kim, Kuhn Park, and Myung Sook Kim
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Cisplatin ,Cancer Research ,medicine.medical_specialty ,business.industry ,Pleural effusion ,medicine.medical_treatment ,medicine.disease ,Surgery ,Chest tube ,Oncology ,medicine ,Cytarabine ,Malignant pleural effusion ,Original Article ,Intrapleural chemotherapy ,business ,Lung cancer ,Saline ,medicine.drug - Abstract
Purpose The purpose of this study was to evaluate the efficacy of intrapleural chemotherapy (IPC) with cisplatin and cytarabine in the management of malignant pleural effusion (MPE) from non-small-cell lung cancer (NSCLC). Materials and methods A prospective analysis was carried out on 40 patients with pathologically proven MPE from NSCLC who had received IPC. A single dose of cisplatin 100 mg/m(2) plus cytarabine 1200 mg/m(2) in 250 ml normal saline was instilled into the pleural space via a chest tube and drained 4 hours later. Patients were evaluated for toxicities and responses at 1, 2, & 3 weeks and then at monthly intervals if possible. Systemic chemotherapy was administered, if the patient agreed to receive it, after achieving complete control (CC) of MPE. Results The median duration of chest tube insertion for drainage was 7 (3 approximately 32) days. Among the assessable 37 patients, CC and partial control (PC) were 32 (86.5%) and 4 (10.8%) patients, respectively (overall response rate 97.3%). The median duration of response was 12 months (2 approximately 23) and there were only two relapses of IPC after achieving CC. Among the 35 patients who were assessable until they died, 28 patients (80.0%) maintained CC until the last follow-up. There was only one toxic death and the toxicities of IPC, versus the results obtained, were deemed acceptable. Conclusion The procedures were tolerable to the patients and chemotherapy-induced complications were at an acceptable level. The outcome of this trial indicates that IPC has a superior and long lasting treatment response in the management of patients with MPE from NSCLC.
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- 2003
109. Clinical outcomes of extracorporeal membrane oxygenation support in patients with hematologic malignancies
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Hye Seon Kang, Hea Yon Lee, Chin Kook Rhee, Soon Seog Kwon, Young Kyoon Kim, Seok Chan Kim, and Jong Wook Lee
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Adult ,Male ,medicine.medical_specialty ,Complications ,Time Factors ,Pulmonology ,medicine.medical_treatment ,Treatment outcome ,Kaplan-Meier Estimate ,Hematologic Neoplasms ,Risk Assessment ,Medical Records ,Extracorporeal Membrane Oxygenation ,Predictive Value of Tests ,Risk Factors ,Republic of Korea ,Extracorporeal membrane oxygenation ,Adults ,Humans ,Medicine ,In patient ,Hospital Mortality ,Hematologic neoplasms ,Mortality ,Intensive care medicine ,APACHE ,Aged ,Retrospective Studies ,business.industry ,Medical record ,Retrospective cohort study ,Middle Aged ,Treatment Outcome ,surgical procedures, operative ,Predictive value of tests ,Original Article ,Female ,Risk assessment ,business - Abstract
Background/Aims The clinical outcomes of patients with hematologic malignancies who were treated with extracorporeal membrane oxygenation (ECMO) after the failu re of optimal conventional therapy were determined. Methods The medical records of all patients administered ECMO during their stay in a medical intensive care unit of Seoul St. Mary's Hospital between February 2010 and July 2013 were reviewed retrospectively. Results In total, 15 patients with hematologic malignancies were compared to 33 immunocompetent patients with documented cardiorespiratory failure. Underlying hematologic malignancies were significantly associated with lower overall survival (0.0% vs. 24.2%, p = 0.044). Mortality was significantly associated with a higher 24 hours ECMO inspired fraction of oxygen (0.71 ± 0.24 vs. 0.47 ± 0.13, p = 0.015), the development of infection after ECMO (87.5% vs. 25.0%, p = 0.001), and the presence of hyperbilirubinemia (70.0% vs. 0.0%, p < 0.001). Matching of the patients based on their Acute Physiology and Chronic Health Evaluation II scores confirmed the greater risk of mortality in patients with hematologic malignancies (survival: 0.0% vs. 40.0%, p = 0.017). The mean difference in inotropic-equivalent scores after ECMO was significantly lower in the immunocompetent patients than in those with hematologic malignancies (-59.22 ± 97.83 vs. 53.87 ± 164.46, p = 0.026). Conclusions Patients with hematologic malignancies who require ECMO for respiratory support have poor outcomes. The incidence of complications in these patients did not significantly differ from that in immunocompetent patients.
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- 2015
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110. ChemInform Abstract: Synthesis of New Taxol Side Chain Precursor from L-Tartaric Ester
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Hyon‐Kyong Kim and Seok-Chan Kim
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Terpene ,Chemistry ,Side chain ,Organic chemistry ,General Medicine ,Combinatorial chemistry - Published
- 2001
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111. Synthesis of Phloroglucinol Using Microwave-Assisted Reaction from TNT
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Jin Seuk Kim, Woonghee Lee, and Seok Chan Kim
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chemistry.chemical_compound ,chemistry ,Organic reaction ,Phloroglucinol ,Organic chemistry ,Organic synthesis ,General Chemistry ,Resorcinol ,Microwave assisted - Abstract
Recently, microwave assisted reaction has become a powerful tool in organic synthesis, which is being increasingly used to accelerate the organic reactions. Microwave assisted organic reactions have a remarkable merits of increased yields, reduced reaction time, suppressed side products and decreased environ-mental pollution.
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- 2009
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112. Pylephlebitis and Multiple Liver Abscesses Caused by Band Erosion Following Laparoscopic Adjustable Gastric Banding
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Ji Hye Kim, Seok-Chan Kim, Hyun Seon Kim, Sung Kyun Park, Jongmin Lee, Kyunghoon Kim, and Seon-Ah Cha
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medicine.medical_specialty ,Pylephlebitis ,business.industry ,Erosion ,Medicine ,business ,medicine.disease ,Laparoscopic adjustable gastric banding ,Surgery - Published
- 2014
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113. A Case of Atypical Manifestation of Pulmonary Alveolar Proteinosis Associated with Myelodysplastic Syndrome
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Seok Chan Kim, Yae Ni Kim, Ji Won Han, Hea Yon Lee, Jaeyoung Kim, Yoo-Jin Kim, and Ji Young Kang
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Weakness ,Pathology ,medicine.medical_specialty ,Lung ,Tuberculosis ,business.industry ,Myeloid leukemia ,Lung biopsy ,medicine.disease ,medicine.anatomical_structure ,Bronchiolitis ,hemic and lymphatic diseases ,Medicine ,medicine.symptom ,business ,Pulmonary alveolar proteinosis ,Rare disease - Abstract
Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the accumulation of lipoproteinaceous material in the distal air spaces. Secondary forms of PAP are caused by underlying diseases, in particular tumorous conditions, the most common of which are hematologic malignancies, such as chronic myeloid leukemia and myelodysplastic syndrome (MDS). We herein describe a case of atypical manifestation of PAP caused by MDS, which initially mimicked military tuberculosis with severe thrombocytopenia because of radiologic features showing necrotic mediastinal lymphadenopathies and diffuse bronchiolitis. A 46-year-old male visited the hospital complaining of coughing and general weakness and was presumptively diagnosed with military tuberculosis combined with MDS. He was treated with antituberculous medication, but the lung lesions did not improve and dyspnea only progressed. Finally, he underwent lung biopsy and was diagnosed with atypical pattern of PAP associated with MDS. (Korean J Med 2014;86:74-78)
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- 2014
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114. Identification of small marker chromosomes using microarray comparative genomic hybridization and multicolor fluorescent in situ hybridization.
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Woori Jang, Hyojin Chae, Jiyeon Kim, Jung-Ok Son, Seok Chan Kim, Bo Kyung Koo, Myungshin Kim, Yonggoo Kim, In Yang Park, and In Kyung Sung
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CHROMOSOMES ,IN situ hybridization ,FLUORESCENCE in situ hybridization ,PRENATAL diagnosis ,GENETIC counseling ,CYTOGENETICS ,HETEROCHROMATIC genes - Abstract
Background: Marker chromosomes are small supernumerary chromosomes that cannot be unambiguously identified by chromosome banding techniques alone. However, the precise characterization of marker chromosomes is important for prenatal diagnosis and proper genetic counseling. In this study, we evaluated the chromosomal origin of marker chromosomes using a combination of banding cytogenetics and molecular cytogenetic techniques including diverse fluorescence in situ hybridization (FISH) assays and array comparative genomic hybridization (array CGH). Results: In a series of 2871 patients for whom cytogenetic analysis was requested, 14 cases with small supernumerary marker chromosomes (sSMCs) were identified. Nine sSMCs were mosaic, and five nonmosaic. Of the nine cases with known parental origins, four were identified as de novo, and four and one were maternally and paternally inherited, respectively. Six sSMCs were identified by FISH using centromeric probes; three sSMCs were derived from chromosome 15, including two heterochromatic sSMC(15)s and a large sSMC(15) spanning 15q11.1q13.1, and three sSMCs originated from chromosome 14 or 22. Array CGH revealed two cases with derivatives of chromosome 2 and whole chromosome painting multicolor-FISH (M-FISH) identified three cases with derivatives of chromosome 6, 16, and 19, respectively. One maker chromosome in Turner syndrome was characterized as sSMC(X) by preferential application of a centromeric probe for X-chromosome. In addition, one sSMC composed of genomic materials from chromosomes 12 and 18 was identified in parallel with parental karyotype analysis that revealed the reciprocal balanced translocation. Conclusions: This report is the largest study on sSMCs in Korea and expands the spectrum of sSMCs that are molecularly characterized. [ABSTRACT FROM AUTHOR]
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- 2016
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115. Depth of Pleural Effusion in Thoracentesis: Comparison of Lateral, Posterolateral and Posterior Approaches in the Supine Position.
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Jeong Min Ko, Jisoon Kim, Soo-An Park, Kwang Nam Jin, Myeong Im Ahn, Seok-Chan Kim, and Dae Hee Han
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ATELECTASIS ,CHEST paracentesis ,COMPUTED tomography ,DEAD ,PATIENT safety ,PLEURAL effusions ,PROBABILITY theory ,SUPINE position ,DESCRIPTIVE statistics - Abstract
Background: In patients who have difficulty sitting, thoracentesis is attempted in a supine position via lateral approach. Recently, a new table has been designed for supine thoracentesis. This table has gaps that allow access to the posterolateral and posterior hemithorax. Objectives: To compare important safety-related parameters between lateral, posterolateral, and posterior approaches in supine thoracentesis. Materials and Methods: First, two cadavers were placed supine on a table featuring gaps allowing access to the posterolateral and posterior hemithorax. Water was administered with sonographic measurement of the depth of pleural effusion (DPE) at the mid-axillary and posterior axillary line. Second, CT images were analyzed in 25 consecutive patients (32 free-shifting, moderate-tolarge effusions; mean, 668 (146 - 2020 mL). DPE, craniocaudal distance that effusion can be visualized (CCD), and presence of passive atelectasis at each of the lateral, posterolateral, and posterior routes was assessed. Results: In each cadaver, DPE in the posterolateral route was greater than that in the lateral route (P = 0.002, P < 0.001). The amount of pleural fluid enough to spread DPE to higher than 1 cm at the posterior axillary line was less than half the amount at the midaxillary line (500 mL vs. 1,100 mL; 800 mL vs. 1700 mL). CT showed that the DPEs and CCDs of posterolateral and posterior routes were greater than those of the lateral route (P< 0.001). In thirteen effusions (40.6%), DPE was greater than 1cmin both posterolateral and posterior routes but less than 1 cm in the lateral route. Frequencies of passive atelectasis in posterolateral and posterior routes (81.3% and 90.6%) were higher (P < 0.001) than that in the lateral route (28.1%). Conclusion: Safety-related parameters of posterolateral and posterior approaches in supine thoracentesis are far better than that of the conventional lateral approach. [ABSTRACT FROM AUTHOR]
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- 2016
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116. Utility of N-Terminal Pro-B-Type Natriuretic Peptide in Patients Admitted to Intensive Care Unit
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Sunghoon Park, Yoonsuck Koh, Gyu Rak Chon, Ho Cheol Kim, Jaemin Lim, Jae Yeol Kim, Shin Ok Koh, Jin Hwa Lee, Young Joo Lee, So Yeon Lim, Won Il Choi, Seok Chan Kim, Chin Kook Rhee, Ji Hyun Lee, Hea Yon Lee, Je Hyeong Kim, and Gee Young Suh
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,law ,Internal medicine ,Medicine ,In patient ,N terminal pro b type natriuretic peptide ,Cardiology and Cardiovascular Medicine ,Critical Care and Intensive Care Medicine ,business ,Intensive care unit ,law.invention - Published
- 2013
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117. Clinical Significance of Isolations of Nontuberculous Mycobacteria From Respiratory Specimens in Hematopoietic Stem Cell Transplantation Recipients
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Dong-Gun Lee, Chin Kook Rhee, Jick Hwan Ha, Young Kyoon Kim, Hea Yeon Lee, Kihoon Park, Seok Chan Kim, Ji Young Kang, and Sook Young Lee
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Pulmonary and Respiratory Medicine ,biology ,business.industry ,medicine.medical_treatment ,Hematopoietic stem cell transplantation ,Critical Care and Intensive Care Medicine ,biology.organism_classification ,Immunology ,medicine ,Clinical significance ,Nontuberculous mycobacteria ,Respiratory system ,Cardiology and Cardiovascular Medicine ,business - Published
- 2012
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118. Evaluation of Pneumocystis pneumonia Prevalence and Risk Factors in Patients With Positive Polymerase Chain Reaction in Bronchoalveolar Lavage or Washing Fluid
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Seok Chan Kim, Hea Yeon Lee, Seung Joon Kim, Jick Hwan Ha, Young Kyoon Kim, Ji Young Kang, Jae Cheol Kwon, Sung Hak Park, Ah Young Shin, Chin Kook Rhee, and Sook Young Lee
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Bronchial Lavage ,Critical Care and Intensive Care Medicine ,Pneumocystis pneumonia ,medicine.disease ,Gastroenterology ,law.invention ,Bronchoalveolar lavage ,law ,Internal medicine ,Medicine ,In patient ,Cardiology and Cardiovascular Medicine ,business ,Polymerase chain reaction - Published
- 2012
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119. Structure of Intensive Care Unit and Clinical Outcomes in Critically Ill Patients with Influenza A/H1N1 2009
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Jae Hwa Cho, Huyn Kyung Lee, Younsuck Koh, Myung Goo Lee, Gee Young Suh, Sang Hyun Kwak, Jae Min Lim, Seok Chan Kim, Moo Suk Park, Sang-Bum Hong, and Hun Jae Lee
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business.industry ,Critically ill ,law ,education ,medicine ,Intensivist ,Influenza a ,University medical ,Medical emergency ,medicine.disease ,business ,Intensive care unit ,law.invention - Abstract
Departments of Internal Medicine, *Preventive and Social Mecine, Inha University School of Medicine, Department of Internal Medicine, Incheon, University of Ulsan College of Medicine, Seoul, Sungkyunkwan University School of Medicine, Suwon, Yonsei University College of Medicine, The Catholic University of Korea College of Medicine, Seoul, Chonnam National University Medical School, Gwangju, **Hallym Univerity College of Medicine, Chuncheon, Inje University College of Medicine, Busan, Korea
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- 2012
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120. Synthesis of Amlodipine Using Aza Diels-Alder Reaction
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Chan-Seong Cheong, Kwan-Min Choi, and Seok-Chan Kim
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Chemistry ,medicine ,Organic chemistry ,Aza-Diels–Alder reaction ,General Chemistry ,Amlodipine ,medicine.drug - Published
- 2002
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121. The Effect of Learners upon Learning for Development of Multi-Metacognitive Question
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Seok-Chan Kim and Hyeong-Do Heo
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- 2011
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122. Effect of Imatinib and Nilotinib on Bleomycin-Induced Acute Lung Injury and Pulmonary Fibrosis
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Jin Woo Kim, Hyoung Kyu Yoon, Seok Chan Kim, Joong Hyeun Ahn, Yong Hyun Kim, Sung Hak Park, Sang Haak Lee, Young Kyoon Kim, Hwa Sik Moon, and Chi Hong Kim
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Pulmonary and Respiratory Medicine ,business.industry ,Imatinib ,Lung injury ,Critical Care and Intensive Care Medicine ,medicine.disease ,Bleomycin ,chemistry.chemical_compound ,Imatinib mesylate ,Nilotinib ,chemistry ,Pulmonary fibrosis ,medicine ,Cancer research ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Published
- 2010
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123. Clinical Characteristics and Prognostic Factors in Patients with Pulmonary Tuberculosis Admitted to Intensive Care Units
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Ju Sang Kim, Hyeon Hui Kang, Jin Woo Kim, Myung Sook Kim, Ji Young Kang, Seung Soo Kim, Seok Chan Kim, Yong Hyun Kim, Sang Haak Lee, and Hwa Sik Moon
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Mechanical ventilation ,medicine.medical_specialty ,Univariate analysis ,business.industry ,Medical record ,medicine.medical_treatment ,medicine.disease ,Intensive care unit ,Hypoxemia ,law.invention ,Respiratory failure ,law ,Intensive care ,Emergency medicine ,Medicine ,Hypoalbuminemia ,medicine.symptom ,business ,Intensive care medicine - Abstract
Background: Pulmonary tuberculosis (TB), requiring the intensive care unit (ICU) care, has been a high-mortality condition until now. In the present study, we aimed to investigate clinical features and parameters associated with TB mortality. Methods: From August 2003 to December 2008, patients with microbiologically or histologically confirmed pulmonary TB then admitted to the ICU, were retrospectively enrolled into the study. Upon enrollment, their medical records were reviewed. Results: Forty three patients (30 males, 13 females) were included and their mean age was 63.8 years (range:17~87 years). Twelve patients died, an overall in-hospital mortality of 27.8%. The main reason for the ICU care was dyspnea or hypoxemia requiring mechanical ventilation (n=17). Other diagnoses for ICU care were hemoptysis, monitoring after procedures, neurologic dysfunction, shock, and gastrointestinal bleeding. On univariate analysis, the factors affecting the mortality were malnutrition-related parameters including Low body mass index, hypoalbuminemia, Lymphocytopenia, and hypocholersterolemia, as well as severity-related variables such as high acute physiology and chronic health evaluation (APACHE) score, number of involved Lobes, and high C-reactive protein. In addition, respiratory failure requiring mechanical ventilation and acute respiratory distress syndrome contributed to patient fatality. It was shown on multivariate analysis that respiratory failure and hypoalbuminemia were significantly independent variables associated with the mortality. Conclusion: Acute respiratory failure is the most common reason for the ICU care and also the most important factor in predicting poor outcome. In addition, our data suggest that the parameters associated with malnutrition could be possible factors contributing to mortality.
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- 2010
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124. Longitudinal Evaluation of Lung Function Associated with Emphysema in Healthy Smokers
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Suk Young Lee, Sung Hak Park, Yun Su Sim, Kyu Yong Choi, Eunjae Ham, Young Kyoon Kim, and Seok Chan Kim
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Spirometry ,medicine.medical_specialty ,Lung ,medicine.diagnostic_test ,business.industry ,respiratory system ,Former Smoker ,Gastroenterology ,respiratory tract diseases ,Pulmonary function testing ,FEV1/FVC ratio ,medicine.anatomical_structure ,Older patients ,Internal medicine ,behavior and behavior mechanisms ,medicine ,Radiology ,business ,Lung function ,Lung cancer screening - Abstract
Background: Smoking reduces pulmonary function and induces various lung diseases. Recently, the rate of emphysema detection has increased due to lung cancer screening with low-dose chest computed tomography (CT). The purpose of this study was to evaluate changes in lung function associated with emphysema in healthy smokers. Methods: One hundred and ninety one healthy smokers, who had undergone a low-dose chest CT (LDCT) scan as part of lung cancer screening and had revisited the health center after a median 23.9 months` time, were recruited into this study. The severity of emphysema was calculated by the direct observation of a radiologist and a pulmonologist indipendently. Longitudinal changes in lung function according to emphysema based on LDCT and type of smoker was analyzed. Results: Of the participants in this study, 25% of healthy smokers had emphysema, which was mild in severity, in older patients (p=0.003) and in heavy smokers (p<0.001). FEV1/FVC and FEF25-75% were decreased in current smokers with emphysema (p=0.001 and p=0.009, respectively) and without emphysema (p=0.001 and p=0.042). Although lung function was not decreased in ex-smokers without emphysema, FEV1/FVC and FEF25-75% were decreased in ex-smoker with emphysema (p=0.020 and p=0.010). Conclusion: Upon examination with LDCT, the prevalence of emphysema was higher in healthy smokers was than in non-smokers. Lung function was diminished in smokers with emphysema, in spite of former smoker.
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- 2010
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125. Risk factors for acute respiratory distress syndrome during neutropenia recovery in patients with hematologic malignancies
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Kwan Hyung Kim, Hee-Je Kim, Young Kyoon Kim, Seok Lee, Soon Suk Kwon, Chin Kook Rhee, Jin Woo Kim, Jeong Sup Song, Ji Young Kang, Hwa Sik Moon, Sung Hak Park, Yong Hyun Kim, Hyung Kyu Yoon, and Seok Chan Kim
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Male ,medicine.medical_specialty ,ARDS ,Neutropenia ,Critical Care ,Exacerbation ,Critical Illness ,Critical Care and Intensive Care Medicine ,law.invention ,Risk Factors ,law ,hemic and lymphatic diseases ,Intensive care ,Internal medicine ,medicine ,Humans ,Intensive care medicine ,Retrospective Studies ,Respiratory Distress Syndrome ,business.industry ,Research ,Retrospective cohort study ,Middle Aged ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,medicine.disease ,Respiration, Artificial ,Intensive care unit ,Leukemia, Myeloid, Acute ,Pneumonia ,Treatment Outcome ,Respiratory failure ,Hematologic Neoplasms ,Female ,business - Abstract
Introduction Neutropenia recovery may be associated with deterioration in oxygenation and exacerbation of pre-existing pulmonary disease. However, risk factors for acute respiratory distress syndrome (ARDS) during neutropenia recovery in patients with hematologic malignancies have not been studied. Methods We studied critically ill patients with hematologic malignancies with the dual objectives of describing patients with ARDS during neutropenia recovery and identifying risk factors for ARDS during neutropenia recovery. A cohort of consecutive neutropenic patients with hematologic malignancies who were admitted to the intensive care unit (ICU) was studied. During a 6-year period, 71 patients recovered from neutropenia, of whom 38 (53.5%) developed ARDS during recovery. Results Compared with non-ARDS patients, patients who experienced ARDS during neutropenia recovery were more likely to have pneumonia, be admitted to the ICU for respiratory failure, and receive mechanical ventilator therapy. The in-ICU mortality was significantly different between the two groups (86.8% versus 51.5%, respectively, for patients who developed ARDS during neutropenia recovery versus those who did not during neutropenia recovery). In multivariate analysis, only occurrence of pneumonia during the neutropenic episode was associated with a marked increase in the risk of ARDS (odds ratio, 4.76). Conclusions Patients with hematologic malignancies complicated by pneumonia during neutropenia are at increased risk for ARDS during neutropenia recovery.
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- 2009
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126. A Case of Sarcoidosis That Was Initially Misdiagnosed as Nontuberculous Mycobacteria Pulmonary Disease
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Hyun Ho Choi, Yu Ah Hong, Jae Ki Choi, Hyo Lim Kim, Myeong Im Ahn, Hyun Jin Park, Seung Joon Kim, Tae-Jung Kim, Young Kyoon Kim, Seok Chan Kim, Kyo Young Lee, Sung Hak Park, Ju Sang Kim, and Sook Young Lee
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Pathology ,medicine.medical_specialty ,Tuberculosis ,biology ,business.industry ,Incidence (epidemiology) ,Pulmonary disease ,Disease ,biology.organism_classification ,medicine.disease ,Chronic cough ,medicine ,Nontuberculous mycobacteria ,Sarcoidosis ,medicine.symptom ,business ,Mycobacterium - Abstract
There are several respiratory diseases that show chronic granulomatous inflammation for the histologic finding. Among them, sarcoidosis and tuberculosis are not easy to differentiate when the clinical and radiological features present similar patterns. The increasing incidence of nontuberculous mycobacteria pulmonary disease is making it more difficult for clinicians to arrive at a proper diagnosis. A 69 year old male patient visited our hospital with chronic cough as his chief compliant. His radiologic findings w ere multiple enlarged mediastinal lymphadenpathies with innumerable micronodules and multiple patch infiltrations. The spleen biopsy finding showed chronic granulomatous inflammation, and Mycobacterium avium was identified on the bronchoscopic culture. Because of these findings, we treated him with drugs for nontuberculous my cobacteria disease other than sarcoidosis. However, during the treatment, his symptoms and radiological features became aggravated. Thus, we reviewed the radiologic and pathologic findings and decided to treat him with steroid, which relieved his symptoms and improved the radiologic findings. We report here on a case of sarcoidosis that was initially misdiagnosed as nontuberculous mycobacteria pulmonary disease.Key Words: Sarcoidosis, Nontuberculous mycobacteria pulmonary disease, Chronic granulomatous inflammation
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- 2009
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127. An Unusual Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Diffuse Pulmonary Infiltrates with Spontaneous Regression.
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Hye Seon Kang, Hea Yon Lee, Seung Joon Kim, Seok Chan Kim, Young Kyoon Kim, Gyeong Sin Park, Kyo Young Lee, Jung Im Jung, and Ji Young Kang
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LYMPHOID tissue ,B cell lymphoma ,SPONTANEOUS cancer regression ,WOMEN patients ,LUNG biopsy ,FLUORESCENCE in situ hybridization ,CANCER - Abstract
A 57-year-old woman presented with cough and dyspnea for 2 months. Computed tomography of the chest showed diffuse ground-glass opacities in both lungs. Histologic examination via thoracoscopic lung biopsy revealed atypical lymphoproliferative lesion. Her symptoms and radiologic findings of the chest improved just after lung biopsy without any treatment. Therefore, she was discharged and monitored at an outpatient clinic. Two months later, pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma was confirmed by the detection of API2-MALT1 translocation in fluorescent in situ hybridization analysis. Although the lung lesions resolved spontaneously, she received chemotherapy due to bone marrow involvement in her staging workup. Pulmonary MALT lymphoma is rare. Nodular or consolidative patterns are the most frequent radiologic findings. Although the disease has an indolent growth, it rarely resolves without treatment. We report an unusual case of pulmonary MALT lymphoma with diffuse interstitial abnormalities on image and spontaneous regression on clinical course. [ABSTRACT FROM AUTHOR]
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- 2015
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128. Continuous Amplitude-Integrated Electroencephalographic Monitoring Is a Useful Prognostic Tool for Hypothermia-Treated Cardiac Arrest Patients.
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Sang Hoon Oh, Kyu Nam Park, Young-Min Shon, Young-Min Kim, Han Joon Kim, Chun Song Youn, Soo Hyun Kim, Seung Pill Choi, Seok Chan Kim, Oh, Sang Hoon, Park, Kyu Nam, Shon, Young-Min, Kim, Young-Min, Kim, Han Joon, Youn, Chun Song, Kim, Soo Hyun, Choi, Seung Pill, and Kim, Seok Chan
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- 2015
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129. Polyethylene Glycol (PEG-3350, Colyte) Poisoning due to Intra-Peritoneal Leakage in an Elderly Patient.
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Jae Hee Chung, Seok Chan Kim, and Jun-Gi Kim
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POLYETHYLENE glycol ,ELECTIVE surgery ,BOWEL preparation (Procedure) - Abstract
Polyethylene glycol (PEG)-3350 is the most frequently used lavage solution for bowel cleansing prior to colonoscopy or elective surgery because its large molecular weight means that it is poorly absorbed. However, if it leaks into the peritoneal cavity, complications may arise. Few published studies have assessed the absorption, distribution, metabolism and excretion of PEG. Moreover, no published clinical data regarding complications due to the intra-peritoneal leakage of PEG-3350 could be found. We report on an elderly patient who developed the poisoning caused by leaking of PEG-3350 during bowel preparation. It resulted in severe metabolic acidosis, hypernatremia, hyperosmolality and a high anion gap, but it was effectively treated with early continuous renal replacement therapy after surgery [ABSTRACT FROM AUTHOR]
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- 2015
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130. Prognostic Value of Vascular Endothelial Growth Factor (VEGF) and Basic Fibroblast Growth Factor (bFGF) Expression in Resected Non-small Cell Lung Cancer
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Joong Hyun Ahn, Hwa Sik Moon, Seok Hwan Moon, Ji Young Kang, Sook Young Lee, Kwan Hyoung Kim, Jung Mi Lee, Sung Hak Park, Yeong Pil Wang, Sang Hak Lee, Soon Seog Kwon, Seok Chan Kim, Seung Joon Kim, Young Kyoon Kim, Chi Hong Kim, Jeong Sup Song, and Jin Sook Kim
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Pathology ,medicine.medical_specialty ,Squamous-cell carcinoma of the lung ,business.industry ,Angiogenesis ,Basic fibroblast growth factor ,Cancer ,medicine.disease ,Vascular endothelial growth factor ,chemistry.chemical_compound ,HIF1A ,chemistry ,medicine ,Adenocarcinoma ,Lung cancer ,business - Abstract
Background: Tumor angiogenesis plays an important role in tumor growth, maintenance and metastatic potential. Tumor tissue produces many types of angiogenic growth factors. Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) have both been implicated to have roles in tumor angiogenesis. In this study, the expression of tissue VEGF and bFGF from non-small cell lung cancer (NSCLC) patients were analyzed. Methods: We retrospectively investigated 35 patients with a histologically confirmed adenocarcinoma or squamous cell carcinoma of the lung, where the primary curative approach was surgery. An ELISA was employed to determine the expression of VEGF and bFGF in extracts prepared from 35 frozen tissue samples taken from the cancer patients. Results: VEGF and bFGF concentrations were significantly increased in lung cancer tissue as compared with control (non-cancerous) tissue. The VEGF concentration was significantly increased in T2 and T3 cancers as compared with T1 cancer. Expression of VEGF was increased in node-positive lung cancer tissue as compared with node-negative lung cancer tissue (p=0.06). VEGF and bFGF expression were not directly related to the stage of lung cancer and patient survival. Conclusion: Expression of VEGF and bFGF were increased in lung cancer tissue, and the expression of VEGF concentration in lung cancer tissue was more likely related with tumor size and the presence of a lymph node metastasis than the expression of bFGF. However, in this study, expression of both VEGF and bFGF in tissue were not associated with patient prognosis.
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- 2008
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131. A Case of Radiolucent Foreign Body (Temporary Resin Bridge) Aspiration Accompanied by Inflammatory Polyps
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Hae Bin Jeong, Hwa Sik Moon, Sung Kyoung Kim, Ji Myoung Lee, Seol Kyung Moon, Sook Young Lee, Joo Yong Song, Hyeong Kyu Yoon, Seok Chan Kim, and Sang Haak Lee
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medicine.medical_specialty ,business.industry ,Radiography ,Radiodensity ,medicine.disease ,Surgery ,Bridge (graph theory) ,Foreign body aspiration ,Respiratory Aspiration ,medicine ,Papilloma ,Radiology ,Foreign body ,business ,Inflammatory polyps - Abstract
Summary This case demonstrates the rare occurrence of a radio-lucent temporary resin bridge aspiration in adults while they are in a conscious and awaken state and the re-sultant formation of inflammatory polyps. Although no unique findings were noted in a chest x-ray, careful his-tory taking accompanied by physical examinations can lead to clinical suspicion of foreign body aspiration in an earlier stage. Moreover, flexible bronchoscopy is a tool useful not only for the evaluation process but also for managing the aspirated foreign material. References 1.Dikensoy O, Usalan C, Filiz A. Foreign body aspiration: clinical utility of flexible bronchoscopy. Postgrad Med J 2002;78:399-403.2.Sersar SI, Rizk WH, Bilal M, El Diasty MM, Eltantawy TA, Abdelhakam BB, et al. Inhaled foreign bodies: pre-sentation, management and value of history and plain chest radiography in delayed presentation. Otolaryngol Head Neck Surg 2006;134:92-9.3.Applegate KE, Dardinger JT, Lieber ML, Herts BR, Davros WJ, Obuchowski NA, et al. Spiral CT scanning technique in the detection of aspiration of LEGO for-eign bodies. Pediatr Radiol 2001;31:836-40.4.Mattie PA, Rawls HR, Cabasso I. Development of a ra-diopaque, autopolymerizing dental acrylic resin. J Pro-sthodont 1994;3:213-8.5.Barzo P, Molnar L, Minik K. Bronchial papillomas of various origins. Chest 1987;92:132-6.6.Greene JG, Tassin L, Saberi A. Endobronchial epithelial papilloma associated with a foreign body. Chest 1990; 97:229-30. 7.Berman DE, Wright ES, Edstrom HW. Endobronchial inflammatory polyp associated with a foreign body. Successful treatment with corticosteroids. Chest 1984; 86:483-4.
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- 2008
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132. Time Sequence of Airway Remodeling in a Mouse Model of Chronic Asthma: the Relation with Airway Hyperresponsiveness
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Joong Hyun Ahn, Myung Sook Kim, Kwan Hyoung Kim, Jeong Sup Song, Soon Seog Kwon, Chi Hong Kim, Seok Chan Kim, Sung Hak Park, Hwa Sik Moon, Sook Young Lee, Seung Joon Kim, and Young Kyoon Kim
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Time Factors ,Ovalbumin ,Immunoglobulin E ,Mice ,Fibrosis ,medicine ,Animals ,Lung ,Asthma ,Mice, Inbred BALB C ,biology ,medicine.diagnostic_test ,business.industry ,Pneumonia ,General Medicine ,respiratory system ,medicine.disease ,respiratory tract diseases ,Disease Models, Animal ,Bronchoalveolar lavage ,medicine.anatomical_structure ,Chronic Disease ,Immunology ,biology.protein ,Cytokines ,Female ,Original Article ,Methacholine ,Bronchial Hyperreactivity ,business ,Airway ,medicine.drug - Abstract
During the course of establishing an animal model of chronic asthma, we tried to elucidate the time sequence of airway hyperresponsiveness (AHR), airway inflammation, airway remodeling, and associated cytokines. Seven-week-old female BALB/c mice were studied as a chronic asthma model using ovalbumin (OVA). After sensitization, mice were exposed twice weekly to aerosolized OVA, and were divided into three groups depending on the duration of 4 weeks, 8 weeks, and 12 weeks. At each time point, airway responsiveness, inflammatory cells, cytokines in bronchoalveolar lavage fluids (BALF), serum OVA-specific IgE, IgG1, IgG2a, and histological examination were carried out. AHR to methacholine, increased levels of OVA-specific IgG1 and IgG2a, and goblet cell hyperplasia were continuously sustained at each time point of weeks. In contrast, we observed a time-dependent decrease in serum OVA-specific IgE, BALF eosinophils, BALF cytokines such as IL-13, transforming growth factor-beta1, and a time-dependent increase in BALF promatrix metalloproteinase-9 and peribronchial fibrosis. In this OVA-induced chronic asthma model, we observed airway remodelings as well as various cytokines and inflammatory cells being involved in different time-dependent manners. However, increased airway fibrosis did not directly correlate with a further increase in airway hyperresponsiveness.
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- 2007
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133. Utility of B-type Natriuretic Peptide in Patients with Acute Respiratory Distress Syndrome
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Young Bin Joo, Chin Kook Rhee, Yoon Seok Koh, Sook Young Lee, Sung Hak Park, Seok Chan Kim, and Young Kyoon Kim
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medicine.medical_specialty ,ARDS ,Ejection fraction ,APACHE II ,business.industry ,medicine.drug_class ,Diastole ,Apache II score ,Acute respiratory distress ,medicine.disease ,Internal medicine ,medicine ,Natriuretic peptide ,Cardiology ,In patient ,cardiovascular diseases ,Intensive care medicine ,business ,human activities ,hormones, hormone substitutes, and hormone antagonists - Abstract
Background B-type natriuretic peptide (BNP) has been shown to be strong mortality predictors in a wide variety of cardiovascular syndromes. Little is known about BNP in patients with acute respiratory distress syndrome (ARDS). We studied whether BNP can predict mortality in patients with ARDS. Method Echocardiographic study was done to all patients with ARDS, and we excluded patient with low ejection fraction (less than 50%) or showing any features of diastolic dysfunction. 47 patients were enrolled between December, 2003 and February, 2006. Parameters including BNP were obtained within 24h hours at the time of enrollment. Result Mean BNP concentrations and APACHE II scores differed between the survivors and nonsurvivors (BNP, vs ; p=0.013, APACHE II score, vs , p=0.009, respectively). With the use of the threshold value for BNP of 585 pg/mL, the specificity for the prediction of mortality was 94%. The threshold value for APACHE II of 15.5 showed sensitivity of 87%. 'APACHE II + ' showed sensitivity 63%, and specificity 82%, using threshold value for 46.14. Conclusion BNP concentrations and APCHE II scores were more elevated in nonsurvivors than survivors in patients with ARDS who have normal ejection fraction. BNP can predict mortality. Further study should be done.
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- 2007
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134. A PHASE II STUDY OF BELOTECAN (CKD-602) CAMTOBELL IN PATINETS WITH SCLC
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Hwa Sik Moon, Seok Chan Kim, Jin Woo Kim, Seung Joon Kim, Sung Kyoung Kim, Kwan Hyoung Kim, Young Kyoon Kim, Chi Hong Kim, Sung Hak Park, and Jeong Sup Song
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Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,business.industry ,Internal medicine ,Medicine ,Phases of clinical research ,Cardiology and Cardiovascular Medicine ,Critical Care and Intensive Care Medicine ,business - Published
- 2006
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135. Effect of pressurization methods on the accuracy of wrist blood pressure measurement.
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Jong Pal Kim, Sangkon Bae, Youn Ho Kim, KyoungHo Kang, Byung-Hoon Ko, Seok Chan Kim, and Kunsoo Shin
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- 2010
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136. Factors affecting the accuracy of volume-oscillometric blood pressure measurement during partial pressurization of the wrist.
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Jong Pal Kim, Youn Ho Kim, Sangkon Bae, Seok Chan Kim, and Kunsoo Shin
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- 2009
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137. A Case of Methotrexate Induced Pneumonitis in a Patient with Rheumatoid Arthritis
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Sung Hak Park, Sang Haak Lee, Seok Chan Kim, Wan-Uk Kim, Jeong Sup Song, Kon Ho Shim, Hwa Sik Moon, Sook Young Lee, Chan Seok Park, and Kwan Hyoung Kim
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Pulmonary Complication ,medicine.disease ,Dermatology ,Surgery ,Mononuclear cell infiltration ,Infectious Diseases ,Rheumatoid arthritis ,medicine ,Eosinophilia ,Methotrexate ,medicine.symptom ,business ,Complication ,Hypersensitivity pneumonitis ,medicine.drug ,Pneumonitis - Abstract
저자들은 급성호흡곤란을 주소로 내원한 류마티스 관절염 환자에서 임상소견과 흉부 방사선소견, 기관지폐포세척액 및 경기관지폐생검을 통해 methotrexate에 의한 간질성 폐렴 1예를 진단하였기에 문헌 고찰과 함께 보고하는 바이다. 【Methotrexate is commonly used in rheumatoid arthritis as an anti-inflammatory agent, but treatment with methotrexate can lead to severe side effects, especially pulmonary complication. Interstitial pneumonitis is one of the most important pulmonary adverse effects of methotrexate and most patient present with a subacute febrile illness and peripheral eosinophilia is seen in about a half of patients. Almost all patients have abnormal chest roentgenograms and bibasilar interstitial infiltration with alveolar pulmonary consolidations is the most characteristic finding. Interstitial inflammation with mononuclear cell infiltration is a characteristic pathologic feature and findings that suggest acute hypersensitivity pneumonitis, such as bronchiolitis, granuloma formation with giant cells, and infiltration with eosinophils are often present. Methotrexate-induced pneumonitis is a potentially life threatening and unpredictable complication but it is difficult to make a definite diagnosis in the absence of high index of clinical suspicion. Early recognition and appropriate management may avoid the serious outcome. Herein we report a case of methotrexate-induced pneumonitis in a patient with rheumatoid arthritis.】
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- 2004
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138. A Case of Pulmonary Artery Involvement as the First Manifestation of Takayasu's Arteritis
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Sung Hak Park, Jeong Sup Song, Young Kyoon Kim, Kitae Kim, Sang Haak Lee, Kyung Sup Song, Hwa Sik Moon, So Hyang Song, Sook Young Lee, Kwan Hyoung Kim, Joon Chang Song, and Seok Chan Kim
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Aorta ,Tuberculosis ,Provisional diagnosis ,business.industry ,Takayasu's arteritis ,Clinical manifestation ,medicine.disease ,Infectious Diseases ,Internal medicine ,medicine.artery ,Pulmonary artery ,medicine ,Cardiology ,cardiovascular diseases ,Arteritis ,Respiratory system ,skin and connective tissue diseases ,business - Abstract
Takayasu’s arteritis is a chronic inflammatory disease that primarily affects large vessels, such as the aorta and its main branches. Pulmonary artery is often involved in Takayasu’s arteritis, but only a few cases have been reported in which pulmonary artery involvement occurred as the initial clinical manifestation. We report one patient who was referred to our institution with the provisional diagnosis of chronic thromboembolic pulmonary hypertension and subsequently diagnosed with Takayasu’s arteritis involving the pulmonary artery. (Tuberculosis and Respiratory Diseases 2004, 56:677-682)
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- 2004
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139. A Case of Primary Pulmonary Hypertension in Pregnancy Presented as Massive Hemoptysis
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Seok Chan Kim, Jeong Sup Song, Soon Suk Kwan, Myung Sook Kim, Kwan Hyoung Kim, Hyoung Doo Kim, Hwa Sik Moon, Young Kyoon Kim, and Sung Hak Park
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Pregnancy ,business.industry ,Disease ,Chest pain ,medicine.disease ,Pulmonary hypertension ,Hypoxemia ,Infectious Diseases ,medicine.artery ,Internal medicine ,Pulmonary artery ,medicine ,Cardiology ,Gestation ,Exertion ,medicine.symptom ,business - Abstract
Primary pulmonary hypertension (PPH) is a rare, progressive and incurable disease, which is characterized by an increase in the pulmonary artery pressure without a demonstrable cause. The most common presenting symptom is dyspnea on exertion, with other symptoms comprising of chest pain, syncope and hemoptysis. The diagnosis is one of exclusion of any of the known causes of pulmonary hypertension. When associated with pregnancy, the maternal mortality ranges from 30 to 50%. Because pregnancy and labor are very serious problems for patients with PPH, the available evidence suggests that pregnancy when afflicted with PPH should be avoided. In account the case of a 33- year old patient, reporting with massive hemoptysis, and diagnosed with PPH during her twenty seventh week of gestation, is presented. She was treated with conservative management, including oxygen and a vasodilator, and underwent a pregnancy termination. However, due to aggravation of right heart failure, she presented with severe systemic hypotension and hypoxemia, and eventually died. This case is reported, with brief review of the literature. (Tuberc Respir Dis 2004; 57:66-67)
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- 2004
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140. Markers of poor outcome in patients with acute hypoxemic respiratory failure.
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Won-Il Choi, Esmeralda Shehu, So Yeon Lim, Shin Ok Koh, Kyeongman Jeon, Sungwon Na, Chae-Man Lim, Young-Joo Lee, Seok Chan Kim, Ick Hee Kim, Je Hyeong Kim, Jae Yeol Kim, Jaemin Lim, Chin Kook Rhee, Sunghoon Park, Ho Cheol Kim, Jin Hwa Lee, Ji Hyun Lee, Jisook Park, and Younsuck Koh
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HYPOXEMIA ,LIVER disease diagnosis ,ANTHROPOMETRY ,BIOMARKERS ,CHI-squared test ,CRITICAL care medicine ,HEART diseases ,INTENSIVE care units ,LONGITUDINAL method ,EVALUATION of medical care ,MEDICAL needs assessment ,PNEUMONIA ,ADULT respiratory distress syndrome ,PULMONARY function tests ,RESPIRATORY insufficiency ,SEPSIS ,U-statistics ,COMORBIDITY ,DATA analysis ,BODY mass index ,ACQUISITION of data ,RESPIRATORY aspiration ,POSITIVE end-expiratory pressure ,DIAGNOSIS - Published
- 2014
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141. Impact of Eastern Cooperative Oncology Group Performance Status on hospital mortality in critically ill patients.
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Park, Chi-Min, Koh, Younsuck, Jeon, Kyeongman, Na, Sungwon, Chae-Man Lim, Won-Il Choi, Young-Joo Lee, Seok Chan Kim, Gyu Rak Chon, Je Hyeong Kim, Jae Yeol Kim, Jaemin Lim, Chin Kook Rhee, Park, Sunghoon, Ho Cheol Kim, Jin Hwa Lee, Ji Hyun Lee, Park, Jisook, Juhee Cho, and Shin Ok Koh
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CHI-squared test ,CLINICAL medicine ,CONFIDENCE intervals ,CRITICAL care medicine ,CRITICALLY ill ,EPIDEMIOLOGY ,FAMILIES ,GROUP medical practice ,HOSPITALS ,MEDICAL needs assessment ,MEDICAL societies ,MORTALITY ,ONCOLOGY ,PATIENTS ,PHYSICIANS ,QUESTIONNAIRES ,OPERATIVE surgery ,COMORBIDITY ,DATA analysis ,KEY performance indicators (Management) ,HEALTH literacy ,DATA analysis software - Published
- 2014
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142. Usefulness of N-terminal pro-B-type natriuretic peptide in patients admitted to the intensive care unit: a multicenter prospective observational study.
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Chin Kook Rhee, So Yeon Lim, Shin Ok Koh, Won-Il Choi, Young-Joo Lee, Gyu Rak Chon, Je Hyeong Kim, Jae Yeol Kim, Jaemin Lim, Sunghoon Park, Ho Cheol Kim, Jin Hwa Lee, Ji Hyun Lee, Jisook Park, Younsuck Koh, Gee Young Suh, and Seok Chan Kim
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CHI-squared test ,FISHER exact test ,HOSPITALS ,INTENSIVE care units ,DEATH rate ,PEPTIDE hormones ,PROGNOSIS ,STATISTICS ,U-statistics ,LOGISTIC regression analysis ,DATA analysis ,RECEIVER operating characteristic curves ,DATA analysis software - Abstract
Background: The role of N-terminal pro-B-type natriuretic peptide (NT- pro-BNP) as a prognostic factor in patients admitted to the intensive care unit (ICU) is not yet fully established. We aimed to determine whether NT-pro-BNP is predictive of ICU mortality in a multicenter cohort of critically ill patients. Methods: A total of 1440 patients admitted to 22 ICUs (medical, 14; surgical, six; multidisciplinary, two) in 15 tertiary or university-affiliated hospitals between July 2010 and January 2011 were assessed. Patient data, including NT-pro-BNP levels and Simplified Acute Physiology Score (SAPS) 3 scores, were recorded prospectively in a web-based database. Results: The median age was 64 years (range, 53-73 years), and 906 (62.9%) patients were male. The median NT-pro-BNP level was 341 pg/mL (104-1,637 pg/mL), and the median SAPS 3 score was 57 (range, 47-69). The ICU mortality rate was 18.9%, and hospital mortality was 24.5%. Hospital survivors showed significantly lower NT-pro-BNP values than nonsurvivors (245 pg/mL [range, 82-1,053 pg/mL] vs. 875 pg/mL [241-5,000 pg/mL], respectively; p < 0.001). In prediction of hospital mortality, the area under the curve (AUC) for NT-pro-BNP was 0.67 (95% confidence interval [CI], 0.64-0.70) and SAPS 3 score was 0.83 (95% CI, 0.81-0.85). AUC increment by adding NT-pro-BNP is minimal and likely no different to SAPS 3 alone. Conclusions: The NT-pro-BNP level was more elevated in nonsurvivors in a multicenter cohort of critically ill patients. However, there was little additional prognostic power when adding NT- pro-BNP to SAPS 3 score. [ABSTRACT FROM AUTHOR]
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- 2014
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143. Clinical Analysis of Pulmonary Hamartoma: 29 Cases
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Kwan Hyoung Kim, Kyo Young Lee, Chi Hong Kim, Seok Chan Kim, Young Mi Choi, Sang Haak Lee, Hyung Kyu Yoon, Sung Hak Park, Young Kyoon Kim, Hwa Sik Moon, So Hyang Song, Sook Young Lee, Soon Seog Kwon, Jeong Sup Song, and Joong Hyun Ahn
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Pulmonary and Respiratory Medicine ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Lung ,Clinical pathology ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,medicine.disease ,Asymptomatic ,Surgery ,Infectious Diseases ,Fine-needle aspiration ,medicine.anatomical_structure ,Biopsy ,medicine ,Hamartoma ,Radiology ,medicine.symptom ,business ,Calcification - Abstract
Background : Pulmonary hamartomas are the most common form of benign tumors, occurring in approximately 0.2% of routine autopsies. However, only a few reports on the clinical characteristics of pulmonary hamartoma in Korea have been published. Materials and Methods : The charts, X-rays and pathological specimens of 29 pulmonary hamartoma patients who were diagnosed by a pathological examination from 1990 to 1999 at the Catholic Medical Center were retrospectively reviewed. Results : The peak incidence of the tumor occurred in the sixth decade of life (37.5%). Seventeen patients (58.6%) were asymptomatic and 12 patients (41.4%) had symptoms. Chest discomfort was the most common symptom (31.0%). A total of 25 tumors (86.2%) were parenchymal, and 4 (13.8%) were endobronchial. Twenty cases were in the right lung and 9 cases were in the left lung (approximately 1:2.2). The RLL was the most commonly involved lobe (31.0%). Calcification was noted in 5 cases(19.2%) on a plain X-ray and in 5 cases (29.4%) on chest CT. Accompanied neoplasms were observed in 2 cases. Twenty-four hamartomas (82.8%) were diagnosed by a surgical resection and 4 cases(13.8%) were diagnosed by a fine needle aspiration biopsy. Twenty-six hamartomas (89.7%) were managed by a surgical resection. The follow up ranged from 4 to 55 months (mean, 19.6 months) and no recurrent pulmonary hamartomas were noted. Conclusion : Pulmonary hamartoma is more common in females and more commonly in the right lung. Calcification was noted only in 19.2% on a plain chest X-ray and 29.4% on a chest CT. No recurrent hamartomas had developed during the follow up period.
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- 2002
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144. The Effect of Midazolam As Sedative Agent in Bronchoscopy
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Hwa Sik Moon, Sook Young Lee, Jeong Sup Song, Seok Chan Kim, Sung Hak Park, Dae Sung Hyun, Sang Haak Lee, Kwan Hyoung Kim, and Young Kyoon Kim
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Infectious Diseases ,Bronchoscopy ,medicine.diagnostic_test ,business.industry ,Anesthesia ,Sedative agent ,Medicine ,Midazolam ,business ,medicine.drug ,Surgery - Abstract
연구배경 : 기관지내시경은 호흡기질환의 진단과 치료에 유용한 도구로 널리 이용되고 있다. 그러나 상당수의 환자가 검사시 고통을 느끼거나 불안감을 느끼고 있어 이를 경감시켜주기 위한 전처치가 필요하다. 저자들은 전처치 약제로 midazolam의 안정성과 효과를 평가하고 또한 적절한 용량을 알아보고자 본 연구를 시행하였다. 방 법 : 연속적으로 기관지내시경을 시행한 180명의 환자를 대조군, midazolam 0.03 mg/kg군, midazolam 0.06 mg/kg군으로 분류하여 검사자와 내시경보조 간호사, 환자의 만족도를 비교하였다. 또한 검사중 혈압과 심박 및 산소포화도의 변화를 측정하였고 기침의 횟수와 lidocaine의 사용량을 측정하였다. 환자의 회복상태는 내시경검사 종료 후 10분간격으로 검사하였다. 결 과 : 각군간에 연령, 성별, 신장, 체중 및 검사시간의 차이는 없었다. 검사 전 및 검사중 혈압과 심박수 및 산소포화도는 각 군간에 유의한 차이가 없었으며 기침의 횟수, lidocaine의 투여량 역시 각 군간에 유의한 차이가 없었다. 기관지내시경 종료후 10분 내에 모든 환자에서 회복이 관찰되었다. 검사자 및 간호사의 만족도는 midazolam 0.03 mg/kg군에서 가장 높았으며 환자의 만족도는 midazolam 투여군 모두에서 대조군보다 높은 결과를 나타냈다. 결 론 : 기관지내시경 검사시 전처치로서 midazolam의 정맥투여는 안전한 방법으로 환자의 만족도를 증가시키며 저용량의 midazolam 투여는 의식하 진정작용을 통해 검사자의 만족도 또한 증가시키는 것으로 생각된다. 【Background : Bronchoscopy is an important diagnostic and a therapeutic tool in chest medicine. However, most patients feel that a bronchoscopy is an unpleasant procedure, and it is important to sedate the patients appropriately, particularly where repetitive examinations are required. Midazolam is a sedative drug with amnestic qualities and a rapid 2 hour half-life. This study have attempted to determine the safety, appropriate dosage, and the effect of midazolam premedication in patients who underwent a bronchoscopy. Methods : One hundred and eighty consecutive patients undergoing bronchoscopy were enrolled in this study. The patients received a midzolam doses of 0.03 mg/kg, 0.06 mg/kg, or a placebo. An additional dose of lidocaine, the total number of coughs, and the duration of the procedures were recorded with monitoring the the blood pressure, heart rate, and oxygen saturation. The level of satisfaction was assessed by the patient, bronchoscopist, and the nurse. Results : The blood pressure, pulse rates, oxygen saturation, number of coughs, lidocaine dose, and procedure time in the 3 groups were similar. There was a trend for the midazolam 0.03 mg/kg group to satisfy bronchoscopists more than the other two groups. The nurses' acceptability was lower in the midazolam 0.06 mg/kg group than the other groups. The patients' acceptablity was greater in both the midazolam 0.03 mg/kg and 0.06 mg/kg groups than in the control group. Conclusion : Sedation with low doses of intravenous midazolam is a safe technique for fiberoptic bronchoscopy with a low morbidity and high acceptable to patients and bronchoscopists.】
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- 2002
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145. Anti-inflammatory Effects of Pentoxifylline and Neutrophil Elastase Inhibitor on Lipopolysaccharide-Induced Acute Lung Injury In Vitro
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Hwa Sik Moon, Kwan Hyoung Kim, Seung Joon Kim, Young Kyoon Kim, Sang Ho Kim, Sung Hak Park, Jeong Sup Song, Yong Keun Park, and Seok Chan Kim
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Pulmonary and Respiratory Medicine ,biology ,business.industry ,Monocyte ,Inflammation ,Lung injury ,Pharmacology ,Pentoxifylline ,Proinflammatory cytokine ,Interleukin 10 ,Infectious Diseases ,medicine.anatomical_structure ,Neutrophil elastase ,Immunology ,medicine ,biology.protein ,Tumor necrosis factor alpha ,medicine.symptom ,business ,medicine.drug - Abstract
Background : Acute lung injury (ALI) is a commonly encountered respiratory disease and its prognosis is poor when the treatment is not provided promptly and properly. However no specific pharmacologic treatment is currently available for ALI, although recently several supportive drugs have been under scrutiny. We studied anti-inflammatory effects of pentoxifylline (PF), a methylated xanthine, and ONO-5046, a synthetic neutrophil elastase inhibitor on lipopolysaccharide (LPS)-induced ALI in vitro. Methods : To establish an in vitro model of LPS-induced ALI, primary rat alveolar macrophages and peripheral neutrophils in various ratios (1:0, 5:1, 1:1, 1:5, 0:1) were co-cultured with transformed rat alveolar epithelial cells (L2 cell line) or vascular endothelial cells (IP2-E4 cell line) under LPS stimulation. Each experiment was divided into five groups-control, LPS, LPS+PF, LPS+ONO, and LPS+PF+ONO. We compared LPS-induced superoxide anion productions from primary rat alveolar macrophages and peripheral neutrophils in various ratios, and the resultant cytotoxicity on L2 cells or IP2-E4 cells between groups. In addition we also compared the productions of tumor necrosis factor (TNF)- interleukin (IL)-, monocyte chemotactic protein(MCP)-1, IL-6, and IL-10 as well as mRNA expressions of TNF- inducible nitric oxide synthetase(iNOS), and MCP-1 from LPS-stimulated primary rat alveolar macrophages between groups. Results : (1) PF and ONO-5046 in each or both showed a trend to suppress LPS-induced superoxide anion productions from primary rat alveolar macrophages and peripheral neutrophils regardless of their ratio, except for the LPS+PF+ONO group with the 1:5 ratio, although statistical significance was limited to a few selected experimental conditions. (2) PF and ONO-5046 in each or both showed a trend to prevent IP2-E4 cells from LPS-induced cytotoxicity by primary rat alveolar macrophages and peripheral neutrophils regardless their ratio, although statistical significance was limited to a few selected experimental conditions. the effects of PF and/or ONO-5046 on LPS-induced L2 cell cytotoxicity varied according to experimental conditions. (3) PF showed a trend to inhibit LPS-induced productions of INF- MCP-1, and IL-10 from primary rat alveolar macrophages. ONO-5046 alone didnot affect the LPS-induced productions of proinflammatory cytokines from primary rat alveolar macrophages but the combination of PF and ONO-5046 showed a trend to suppress LPS-induced productions of INF- and IL-10 PF and ONO-5046 in each or both showed a trend to increase LPS-induced IL- and IL-6 productions from primary rat alveolar macrophages. (4) PF and ONO-5046 in each or both showed a trend to attenuate LPS-induced mRNA expressions of TNF- and MCP-1 from primary rat alveolar macrophages but at the same time showed a trend increase iNOS mRNA expression. Conclusion : These results suggest that PF and ONO-5046 may play a role in attenuating inflammation in LPS-induced ALI and that further study is needed to use these drugs as a new supportive therapeutic strategy for ALI.
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- 2000
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146. A Multicenter, Randomized, Open, Comparative Study for the Efficacy and Safety of Oral Moxifloxacin 400 mg Once a Day and Clarithromycin 500 mg Twice Daily in Korean Patients with Acute Exacerbations of Chronic Bronchitis
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Hyeong Kyu Yoon, Man Pyo Chung, Seung Joon Kim, Sung Hak Park, Kyung Ho Kang, Shin Hyung Lee, Seok Chan Kim, Young Kyoon Kim, Jeong Sup Song, Sook Young Lee, Sung Chul Hwang, Gee Young Suh, Tae Yon Kim, Myung Ho Ha, Hojoong Kim, Eh Hyung Lee, and O Jung Kwon
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Mycoplasma pneumoniae ,Chronic bronchitis ,biology ,business.industry ,Klebsiella pneumoniae ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,medicine.disease_cause ,biology.organism_classification ,Haemophilus influenzae ,Surgery ,Moraxella catarrhalis ,Infectious Diseases ,Moxifloxacin ,Internal medicine ,Clarithromycin ,Streptococcus pneumoniae ,medicine ,business ,medicine.drug - Abstract
Background : Moxifloxacin is a newly developed drug which is more potent and safe compared to previous fluoroquinolones. This drug effectively eradicates organisms such as beta-lactamase-producing or other resistant bacteria. Moxifloxacin is known to be effective in treating respiratory infections such as Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Chlamydia pneumoniaeme, Legionella spp. and Mycoplasma pneumoniae. Methods : In a multicenter, randomized, open, comparative study, the efficacy and safety of oral moxifloxacin taken 400 mg once a day and clarithromycin taken 500 mg twice daily for 7 days were compared for the treatment of Korean patients with acute exacerbations of chronic bronchitis. Results : A total of 170 patients were enrolled, and they were divided into two groups: 87 in the moxifloxacin group and 83 in the clarithromycin group. Of those enrolled, 76 (35 for bacteriologic efficacy) in the moxifloxacin group and 77 (31 for bacteriologic efficacy) in the clarithromycin group were included in the efficacy analysis. All were included in the safety analysis. Clinical success was noted in 70 (92.1%) of 76 moxifloxacin-treated patients and 71 (92.2%) of 77 clarithromycin-treated patients. Bacteriologic success rate seemed to be higher in moxifloxacin group (73.5%) than in clarithromycin group (54.8%), but statistically insignificant (p=0.098). Drug susceptibility among organisms initially isolated was higher in moxifloxacin group on Streptococcus pneumoniae, Pseudomonas aeruginosa, Klebsiella pneumoniae (p
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- 2000
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147. The Levels of Interferon-gamma, Interleukin-2 Receptor, Interleukin-6 and Interleukin-10 in the patients with Malignant Pleural Effusion, Tuberculosis Effusion, Parapneumonic Effusion, and Lung Emphysema?
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Kwan Hyoung Kim, Yong Keun Park, Jeong Sup Song, Myung Hoon Kim, Seok Chan Kim, Hwa Sik Moon, Sung Hak Park, Sook Young Lee, Seung Joon Kim, and Young Kyoon Kim
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung ,Tuberculosis ,business.industry ,medicine.disease ,Gastroenterology ,Parapneumonic effusion ,Interleukin 10 ,Infectious Diseases ,medicine.anatomical_structure ,Effusion ,Pleurisy ,Internal medicine ,Medicine ,Malignant pleural effusion ,Lung emphysema ,business - Abstract
Background : Cytokines are chemical mediators that control and modulate many inflammatory processes. They work in different fashions in a variety of diseases. Discriminating between malignant effusion, tuberculous effusion, and parapneumonic effusion are crucial from the clinical view-point in Korea. In the current study, interferon-gamma (IFN-), soluble interleukin-2 receptor (IL-2R), interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured for this purpose. Methods : Pleural fluids from patients with malignant disease, tuberculosis, parapneumonic effusion and lung empysema were collected and gauged using commercial ELISA kits. Results : 34 patients were enrolled in this study. Among these 15 cases were malignant effusions, 12 were tuberculosis pleurisy and 7 were parapneumonic effusion and lung empyema. The levels of cytokines measured in this study were as follows, in order of frequency, malignant effusion, tuberculous effusion, parapneumonic effusion and lung empyema. The levels of INF- were higher in tuberculous effusion than in malignant or parapneumonic effusion ( vs. vs. pg/ml, p>0.05). The levels of IL-2R were higher in tuberculous effusion than in malignant or parapneumoruc effusion ( vs. vs. pg/ml, p pg/ml in malignant effusion, pg/ml in tuberculous effusion, pg/ml in parapneumoruc effusion). IL-10 levels were higher in parapneumoruc effusion than in malignant or tuberculous effusions ( vs. vs. pg/ml, p
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- 2000
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148. A Case of lymphangitic carcinomatosis of lung presented as rapidly exacerbating reticulonodular infiltrates
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Hwa Sik Moon, Jeong Sup Song, Jung Jung, Young Mee Choi, Sook Young Lee, Jae Soon Jang, Hyun Jung Joo, Sang Haak Lee, Dae Seong Hyun, Seok Chan Kim, Dong Seung Yeo, and Sung Hak Park
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Pathology ,Lung ,medicine.diagnostic_test ,Dry cough ,business.industry ,respiratory system ,respiratory tract diseases ,Hypoxemia ,Infectious Diseases ,medicine.anatomical_structure ,Lymphatic system ,Bronchoscopy ,Lymphangitic Carcinomatosis ,medicine ,Radiology ,Differential diagnosis ,medicine.symptom ,Chest radiograph ,business - Abstract
A 52-year-old woman was presented with 2-week history of increasing dyspnea and dry cough. The chest radiograph revealed bilateral reticular infiltrates. Radiographic infiltrates were rapidly progressed and symptoms from hypoxemia were aggravated. The patient was intubated and bronchoscopy with transbronchial lung biopsies was performed. Biopsies revealed lymphatic vessels plugged by nests of metastatic adenocarcinoma. She died 11 days after admission despite of intensive ventilatory support. We had difficulties in the diagnosis of lymphangitic lung carcinomatosis at initial presentation of her illness because the progression was unusually rapid. Lymphangitic lung carcinomatosis shoud should be included in the differential diagnosis of patients showing rapidly progressive interstitial radiographic findings. Also, transbronchial biopsy may be a useful tool to confirm the diagnosis.
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- 2000
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149. Changes in Distribution and Morphology of Rat Alveolar Macrophage Subpopulations in Acute Hyperoxic Lung Injury Model
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Hwa Sik Moon, Jeong Sup Song, Sook Young Lee, Sung Hak Park, Seok Chan Kim, Young Kyoon Kim, Soon Seog Kwon, Yoon Kyung Shin, Hyoung Kyu Yoon, Kwan Hyoung Kim, and Sang Haak Lee
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Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,education.field_of_study ,Lung ,business.industry ,Cell ,Population ,respiratory system ,Lung injury ,medicine.disease ,Infectious Diseases ,medicine.anatomical_structure ,Fibrosis ,Alveolar macrophage ,Macrophage ,Medicine ,business ,education ,Percoll - Abstract
Background : In acute lung injury, alveolar macrophages play a pivotal role in the inflammatory process during the initiation phase and in the reconstruction and fibrosis process during the later phase. Recently, it has been proven that alveolar macrophages are constituted by morphologically, biochemically and immunologically heterogenous cell subpopulations. The possibility of alterations to these characteristics of the alveolar macrophage population during lung disease has been raised. To investigate such a possibility a hyperoxic rat lung model was made to check the distributional and morphological changes of rat alveolar macrophage subpopulation in acute hyperoxic lung injury. Method : Alveolar macrophage were lavaged from normal and hyperoxic lung injury rats and separated by discontinuous gradients of percoll. After cell counts of each density fraction were accessed, the morphomeric analysis of alveolar macrophages was performed on cytocentrifuged preparations by transmission electron micrograph. Result : 1. The total alveolar macrophage cell count significantly increased up to 24 hours after hyperoxic challenge (normal control group , 12 hour group , 24 hour group , p) did not show a significant difference. 2. Alveolar septal thickness significantly increased up to 24 hours after hyperoxic challenge(normal control group , 12 hour group , 24 hour group , p). Number of interstitial macrophage markedly increased at 24 hour group. 3. Hypodense fraction(fraction 1 and fraction 2) of alveolar macrophage showed a significant increase following hyperoxic challenge (.. p. p
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- 2000
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150. Effect of Interleukin-12 on the Expression of E-selectin in Mouse Model of Lewis Lung Carcinoma
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Jeong Sup Song, Hyoung Kyu Yoon, Hwa Sik Moon, Seok Chan Kim, Yoon Kyung Shin, Kwan Hyoung Kim, Sook Young Lee, Young Kyoon Kim, Soon Seok Kweon, Sung Hak Park, and Sang Haak Lee
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Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,biology ,business.industry ,Cell adhesion molecule ,medicine.medical_treatment ,Lewis lung carcinoma ,medicine.disease ,Infectious Diseases ,Cytokine ,E-selectin ,biology.protein ,Interleukin 12 ,Medicine ,Tumor necrosis factor alpha ,business ,Lung cancer ,CD8 - Abstract
Background: Interleukin-12 (IL-12) can induce antitumor effects in vivo. This antitumor effect is associated with T cell infiltration but the effect of IL-12 on the steps of T cell migration into the tumor tissue has not been fully elucidated. This study focused on the effect of IL-12 on the tumor growth and the metastasis and on the expression of E-selectin, an adhesion molecule which is activated endothelial specific in its expression. In addition, we studied whether the expression of E-selectin is associated with the TNF-, a cytokine that its production is increased by IL-12 and has functions inducing a variety of adhesion molecules. Methods: Mice of C57BL/6 strain were injected with Lewis lung cancer cells followed by either IL-12, TNF-, or normal saline by intraperitoneal route. Twenty eight days after tumor cell inoculation, metastatic nodules of lung were enumerated and immunohistochemical staining of the subcutaneous tumors were performed with monoclonal antibodies to CD4, CD8, CD16, and E-selectin. In IL-12 treated mice, the subcutaneously implanted Lewis lung tumors were decreased in size and the metastases were also decreased in number compared to control mice. On tumor tissues, increased infiltration of CD4+, CD8+, and CD16+ cells were oberved in IL-12 treated mice compared to control mice. In control mice, E-selectin was absent on tumor vessels, but the expression of E-selectin was increased on tumor vessels of IL-12 treated mice. Administration of TNF- increased not only the expression of E-selectin but also infiltrations of CD4+, CD8+, and CD16+ cells on tumor tissues. Conclusions: These results demonstrate that IL-12 inhibits tumor growth and metastases through infiltrations of inflammatory cells in mouse model of Lewis lung carcinoma and E-selectin may playa role in inflammatory cell recruitment on tumor tissue following IL-12 administration. Also, TNF- may have a role as a mediator responsible for the IL-12 induced expression of E-selectin.
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- 1999
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