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17,216 results on '"Sen, E"'

102. Putnam, Sen e Smith: uma reflexão crítica sobre a teoria econômica neoclássica

Author

Lima, Luiz Antônio de Oliveira and Escolas::EAESP

Subjects
Teoria econômica neoclássica, Economia - Aspectos morais e éticos, Administração de empresas, Reflexão, Economia - Aspectos políticos
Abstract

A proposta deste trabalho é de, a partir de uma crítica da dicotomia juízos de valor/juízos de fato, realizar uma reflexão crítica sobre a 'Teoria Econômica' convencional ou neoclássica e propor uma análise econômica baseada na superação daquela dicotomia. De acordo com Amartya Sem (1999-2007), a análise econômica tem duas raízes: a primeira relacionada à ética e à concepção política, a qual apesar de levantar questões irredutíveis de análise econômica, tem sido desqualificada pela análise econômica moderna, por ser considerada 'não científica' e a outra concepção, a abordagem de engenharia, desenvolvida a partir da análise de estados do sistema econômico, e que procurou basear-se grandemente na 'análise estática' da Física. Este é o veio principal da Teoria econômica convencional e que por causa de sua analogia com os sistemas físicos é considerada 'científica'.

Published
2009

103. GRANDES ESPERANÇAS EM UM MUNDO DE INJUSTIÇAS: INTERFACES ENTRE AMARTYA SEN E CHARLES DICKENS

Author

Pedro Augusto Gravatá Nicoli

Subjects
Economics and Econometrics, Materials Chemistry, Media Technology, Forestry
Abstract

O presente ensaio promove uma aproximação entre a Ideia de Justiça de Amartya Sen e a obra-prima Grandes Esperanças, do romancista inglês Charles Dickens, publicada em 1860, lançando luz sobre aproximações e contrapontos entre a teoria de Sen e a vivência dos personagens de Dickens. Essa correlação parte da epígrafe da obra de Sen, que evoca as injustiças sentidas pelo protagonista Pip, de Grandes Esperanças, na abertura de seu projeto de justiça. Para tanto, as dimensões estruturantes da teoria da justiça de Sen serão revisitadas, como um projeto concreto de remoção de injustiças, nas linhas da argumentação racional e da teoria da escolha social, em contraponto a teorias transcendentes. Por sua vez, o universo do menino Pip, de Grandes Esperanças, revelará o complexo caminho desde a inocência infantil à obsessão e esnobismo, com esperanças e frustrações construídas no cenário da Inglaterra vitoriana, de mazelas profundas da pobreza e desigualdade legadas pela Revolução Industrial. Dickens, nesse sentido, é ao mesmo tempo um crítico ácido de seu tempo, engajando-se na transformação social, e um mestre na exploração da dinâmica psíquica das relações humanas. Assim é que se aproximam os autores pelo retrato pungente da injustiça, a demandar a máxima e imediata remoção. Afastam-se, talvez, no convite à reflexão abstrata do justo e do ético em si, bem como do peso dado às instituições. De todo modo, pensar a justiça nesse espaço compartilhado, em que o poder evocativo e o alcance comunicativo das ideias sejam expandidos, coloca-se como exercício enriquecedor em todos os sentidos.

Published
2014

108. Dollar$ & Sen$e. Common cent$ 15: enough is enough.

Author

Wilkinson I

Subjects
Cost Savings, Equipment and Supplies, Hospital economics, Equipment and Supplies, Hospital statistics & numerical data, Hospital Costs, Inventories, Hospital methods, Models, Econometric, United States, Clinical Laboratory Techniques instrumentation, Equipment and Supplies, Hospital supply & distribution, Inventories, Hospital economics
Published
2003

111. Dollar$Sen$e. Common cent$ 15: enough is enough

Author

Ian, Wilkinson

Subjects
Clinical Laboratory Techniques, Cost Savings, Hospital Costs, Equipment and Supplies, Hospital, Models, Econometric, United States, Inventories, Hospital
Published
2003

114. SOBRE OS CONCEITOS DE JUSTIÇA E LIBERDADE NAS OBRAS DE SEN E FRASER

Author

Amaro de Oliveira Fleck

Subjects
Capability approach, Performance art, Citizen journalism, General Medicine, Sociology, Economic Justice, Epistemology
Abstract

O presente artigo discute as semelhanças e as diferenças entre a abordagem das capabilities, de Amartya Sen, e a teoria da justiça como paridade participativa, de Nancy Fraser. Para tanto, reconstrói, em suas linhas gerais, as teorias dos dois autores e examina as críticas de Fraser a Sen, mostrando que estas são equívocas, assim como são equívocas as supostas vantagens que Robeyns aponta na teoria de Sen. Este artigo conclui ressaltando que as duas teorias têm consequências práticas bastante similares, não obstante o fato de uma ser, principalmente, uma teoria do desenvolvimento e a outra ser uma teoria da justiça.

Published
2013

116. Orthognathic surgery improves quality of life: a survey clinical study.

Author

Sen E, Duran H, Sarı M, Akbulut N, and Demir O

Subjects
Humans, Female, Male, Adult, Surveys and Questionnaires, Dentofacial Deformities surgery, Dentofacial Deformities psychology, Young Adult, Case-Control Studies, Adolescent, Quality of Life, Orthognathic Surgical Procedures psychology
Abstract

Background: The aim of this study was to evaluate the quality of life (QoL) of patients with dentofacial deformity (n = 107) compared with that of healthy individuals (n = 108) from 2019 to 2020., Methods: Oral Health Impact Profile 14 (OHIP-14) and the Orthognathic Quality of Life Questionnaire (OQLQ) were administered to the individuals before surgery (T1) and 6 months after surgery (T2)., Results: Preoperative scores (T1) were greater in the surgical group than in the control group in all domains of both surveys (p ≤ 0.001). Postoperative scores (T2) in the surgery group decreased significantly after surgery in all domains in both surveys (p < 0.001). The OHIP-14 scores in the control group at T2 were significantly greater than those in the other domains except for functional limitation at T1. The type of surgery had no effect on quality of life. Class III patients had higher preoperative scores in certain domains. Postoperative physical disability (p = 0.037), physical pain (p = 0.047), and preoperative social disability (p = 0.030) scores of OHIP-14 awareness of dentofacial aesthetics of OQLQ (p = 0.019) were found to be higher in females than in males., Conclusions: The results showed that orthognathic surgery positively affected quality of life. The control group showed differences in T1 and T2 scores, which can be attributed to their psychological status., (© 2024. The Author(s).)

Published
2024
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117. Evaluation of eyelid features' changes before and after COVID-19 pandemic amongst healthcare and home office workers.

Author

Acar Eser N, Serbest Ceylanoglu K, and Malkoc Sen E

Subjects
Humans, Male, Female, Adult, Middle Aged, N95 Respirators, Pandemics, Masks, COVID-19 epidemiology, Eyelids, SARS-CoV-2, Health Personnel
Abstract

Purpose: To evaluate the eyelid features' changes after N95 face mask (FM) usage in healthcare workers through the new type of Coronavirus Disease 2019 (COVID-19) pandemic and make a comparison with home-office workers as a control group with a computer vision algorithm., Materials and Methods: Sixty healthcare workers and forty control participants with similar demographic features included. Standardized biometric photographs which were taken before and after the COVİD-19 pandemic, analyzed by the ImageJ program (NIH, Bethesda, Md.) software. The distances between the central light reflex on the cornea and the upper (UE) and lower eyelid (LE) were recorded as the marginal reflex distances. (MRD1, MRD2 respectively) Parameters of pretarsal show (PTS) of UE and brow pupil diameter (BPD) were analyzed for both of the eyes., Results: There were no significant differences among the groups' measurements before the COVID-19 pandemic. In healthcare workers' group after the pandemic, values of MRD1, PTS, BPD showed a significant decrease in their right eye (p = 0.001, p = 0.002, p = 0.001 respectively) and same values reduced in the left eyes as well when compared with pre-pandemic measurements. (p = 0.048, p = 0.001, p = 0.001 respectively) PTS and BPD values were decreased for both right and left eyes of the controls. (p = 0.044, p = 0.001 and p = 0.001, p = 0.001 respectively) MRD1 measurements after the pandemic showed no difference either in the right or left eyes of the control group after the pandemic. (p = 0.071 and p = 0.065 respectively)., Discussion: Results showed that both BPD and PTS values decreased independently from the previous FM usage in both of the groups. Even though MRD1 values remained within the normal values, a significant decrease was detected in the healthcare workers group which suggested the cause was newly developed upper eyelid (UE) dermatochalasis after long hours of FM usage. Although it is hard to make a truly objective evaluation both usage of standardized biometric photographs and a computer-based measurement system makes the results reliable., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)

Published
2024
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118. Serial mediation of illness perception and beliefs about medicines in the relationship between patient satisfaction and medication adherence: An evaluation of self-regulatory model in rheumatoid arthritis and ankylosing spondylitis patients.

Author

Temeloglu Sen E, Sertel Berk HO, and Rezvani A

Subjects
Humans, Female, Male, Middle Aged, Adult, Surveys and Questionnaires, Health Knowledge, Attitudes, Practice, Aged, Arthritis, Rheumatoid drug therapy, Arthritis, Rheumatoid psychology, Spondylitis, Ankylosing drug therapy, Spondylitis, Ankylosing psychology, Medication Adherence psychology, Patient Satisfaction
Abstract

This study examined the effect of patient satisfaction on medication adherence through serial mediation of Self Regulatory Model (SRM) components which are illness perception and beliefs about medicines in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). The 222 outpatients ( n RA  = 112; n AS  = 110) were administered a sociodemographic form, the Medication Adherence Report Scale, the Brief Illness Perception Questionnaire, the Short Assessment of Patient Satisfaction, and the Beliefs about Medicines Questionnaire. The results showed that SRM components fully mediated the relationship between patient satisfaction and medication adherence. This proposed model had acceptable and better fit indices than the alternative model where patient satisfaction was introduced as a direct predictor. Furthermore, patient satisfaction, illness perception, and beliefs about medicines had an extremely good relationship, so these may be interpreted as variables of a latent construct of the illness experience which deserves further research in these group of patients., Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Published
2024
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119. Cognitive limits of larval Drosophila : testing for conditioned inhibition, sensory preconditioning, and second-order conditioning.

Author

Sen E, El-Keredy A, Jacob N, Mancini N, Asnaz G, Widmann A, Gerber B, and Thoener J

Subjects
Animals, Cognition physiology, Mushroom Bodies physiology, Inhibition, Psychological, Conditioning, Classical physiology, Brain physiology, Association Learning physiology, Drosophila melanogaster physiology, Larva, Drosophila physiology
Abstract

Drosophila larvae are an established model system for studying the mechanisms of innate and simple forms of learned behavior. They have about 10 times fewer neurons than adult flies, and it was the low total number of their neurons that allowed for an electron microscopic reconstruction of their brain at synaptic resolution. Regarding the mushroom body, a central brain structure for many forms of associative learning in insects, it turned out that more than half of the classes of synaptic connection had previously escaped attention. Understanding the function of these circuit motifs, subsequently confirmed in adult flies, is an important current research topic. In this context, we test larval Drosophila for their cognitive abilities in three tasks that are characteristically more complex than those previously studied. Our data provide evidence for (i) conditioned inhibition, as has previously been reported for adult flies and honeybees. Unlike what is described for adult flies and honeybees, however, our data do not provide evidence for (ii) sensory preconditioning or (iii) second-order conditioning in Drosophila larvae. We discuss the methodological features of our experiments as well as four specific aspects of the organization of the larval brain that may explain why these two forms of learning are observed in adult flies and honeybees, but not in larval Drosophila ., (© 2024 Sen et al.; Published by Cold Spring Harbor Laboratory Press.)

Published
2024
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120. Outcome and Factors Related to Isolated Liver Metastasis due to Breast Cancer.

Author

Sen E, Canbak T, Bostanci O, and Battal M

Subjects
Humans, Female, Middle Aged, Retrospective Studies, Adult, Risk Factors, Prognosis, Aged, Disease-Free Survival, Survival Rate, Turkey epidemiology, Neoplasm Recurrence, Local, Breast Neoplasms pathology, Liver Neoplasms secondary
Abstract

Objective: To determine the associated risk factors for isolated liver metastasis in breast cancer patients and to detect the prognostic factors related to survival., Study Design: Analytical study. Place and Duration of the Study: Department of General Surgery, The University of Health Sciences, Istanbul, Turkiye, from January 2011 to November 2020., Methodology: Patients with breast cancer liver metastasis who experienced surgery were retrospectively analysed for breast cancer and metastases-related characteristics. Descriptive statistical methods were used in the evaluation of data. Survival analyses were estimated by the Kaplan-Meier method. Log-rank and univariable Cox regression tests were utilised to search for prognostic factors' impact on survival., Results: Out of 12 patients, 11 had recurrent disease after a median of 36 months of disease-free survival (DFS) and one patient had de novo metastasis. Grade 3 tumours and increased expression of Ki-67 had a negative effect on DFS. The median follow-up period was 66 months. Survival analysis showed 2- and 3-year progression-free survival (PFS); overall survival rates were 82%, 69%, 92%, and 82%, respectively. Development of liver metastasis in 3 years following breast cancer treatment was linked to worse PFS (p = 0.040)., Conclusion:  Long-term survival is possible for breast cancer survivors with liver metastasis. Disease-free interval is an important determinant. Longer progression-free survival was detected in patients who had developed metastasis after three years of breast cancer treatment., Key Words: Breast cancer, Liver metastasis, Hepatic surgery.

Published
2024
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122. Comparison of the efficacy of occlusal splint and botulinum toxin therapies in patients with temporomandibular disorders with sleep bruxism.

Author

Hosgor H, Altindis S, and Sen E

Subjects
Humans, Female, Male, Adult, Treatment Outcome, Retrospective Studies, Botulinum Toxins therapeutic use, Pain Measurement, Botulinum Toxins, Type A therapeutic use, Middle Aged, Neuromuscular Agents therapeutic use, Cohort Studies, Occlusal Splints, Temporomandibular Joint Disorders drug therapy, Temporomandibular Joint Disorders therapy, Sleep Bruxism drug therapy, Sleep Bruxism therapy
Abstract

Purpose: This study aims to evaluate the efficacy of occlusal splint and botulinum toxin (BTX) therapies for improving the pain scores and mouth opening in patients with temporomandibular disorders (TMD) with sleep bruxism (SB)., Materials and Methods: A retrospective cohort study was conducted based on clinical record reviews of patients with TMD symptoms (e.g., temporomandibular joint [TMJ] pain, masticatory muscle pain, TMJ internal derangements, joint sounds, and limited mouth opening) and SB. The patients were divided into two groups: occlusal splint group and BTX group. Maximum unassisted mouth opening (MMO) and pain score on a visual analogue scale (VAS) before treatment and at 1‑, 3‑, and 6‑month follow-up were analyzed to evaluate the clinical outcomes., Results: A total of 60 patients (49 women and 11 men, mean age 34.63 ± 11.85 years) were enrolled. Each group had 30 patients. The comparisons of the groups at 1 and 3 months after treatment indicated that the BTX group had higher MMO values (P = 0.013 and 0.034, respectively) and lower VAS scores than the occlusal splint group (P = 0.000 and 0.001, respectively). No difference between the two groups was observed 6 months after treatment (P > 0.05)., Conclusions: Both occlusal splint and BTX treatment methods were successful in treating TMD with SB. BTX provided patients with rapid relief in the early period; therefore, BTX can be recommended as a primary treatment option in patients with greater pain., (© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)

Published
2024
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123. Oltre le specificità di genere. Cura e diritti nella prospettiva relazionale di Amartya Sen e Martha Nussbaum.

Author

ERASMO, VALENTINA

Subjects
DEVELOPED countries, BINARY gender system, GENDER, ECONOMIC man, GENDER inequality
Abstract

At the thresholds of 2020, gender differences are still reason of inequalities, even in the most economically advanced countries, as shown by the Global Gender Gap Report. Indeed, democratic and liberal societies are dominated by behavioural 'masculine' dynamics, according to homo economicus' paradigm. Many representatives of feminism, as Ortner, complain the strong competitiveness of homo economicus for representing individual decisions, where are lost those horizons not regulated by markets laws: one of these is caregiving, understood as health and/or home care, where female figures prevail. I would suggest an alternative to these perspectives, androcentric and feminist, which enables to go beyond gender specificity. I have proceeded with Sen's anthropological proposal where man is 'relation' with himself herself, into intrapersonal space, and with the others, into interpersonal space. Thanks to 'multiple identities', we can rediscover the value of reciprocity in social interactions, culminated in the birth of relational goods which returns the importance of care in these interactions which increase social capital, as in caregiving. Since the creation of relational goods two questions arise: on the one hand, asking if this may become the starting point for an expansion of care's reciprocity from the intersubjective domain to their reference community; on the other, discussing whether an ethics of care may coexist with an ethics of rights. The answer is affirmative for both, but it requires the overcoming of gender's dichotomy, where the ethics of care is declined with a female voice, as compassion, and the ethics of rights with a male voice, as rationality. A choral answer is required, able to harmonise, without confusing, the level of care with the respect of rights, like the goals-rights system of Sen in dialogue with the ethics of care of Nussbaum, careful to the most human aspects of the existence. [ABSTRACT FROM AUTHOR]

Published
2020
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126. Skin care dollar$ and sen$e.

Author

Lauderdale, Barbara J.

Abstract

Offers advice from skin specialists Gloria Gaines-Hanna and Christina Von Liggett on how salons can generate business in the lucrative field of skin care. Achievements and accomplishments; List of clients; Creation of a display room in the reception area; Built-in clientele of the salon industry; Importance of one-on-one consultation; Aromatherapy and reflexology; Hand facials.

Published
1994

127. A gain of function mutation in AKT1 increases hexokinase 2 and diminishes oxidative stress in meningioma.

Author

Singh S, Lathoria K, Umdor SB, Singh J, Suri V, and Sen E

Subjects
Humans, Gain of Function Mutation, Hexokinase genetics, Hexokinase metabolism, Oxidative Stress genetics, Proto-Oncogene Proteins c-akt metabolism, Reactive Oxygen Species, Meningeal Neoplasms genetics, Meningioma genetics
Abstract

Increasing evidence suggests the oncogenic role of missense mutation (AKT1-E17K) of AKT1 gene in meningiomas. Upon investigating the connection between the pro-tumorigenic role of AKT1-E17K and cellular metabolic adaptations, elevated levels of glycolytic enzyme hexokinase 2 (HK2) was observed in meningioma patients with AKT1-E17K compared to patients harboring wild-type AKT1. In vitro experiments also suggested higher HK2 levels and its activity in AKT1-E17K cells. Treatment with the conventional drug of choice AZD5363 (a pan AKT inhibitor) enhanced cell death and diminished HK2 levels in AKT1 mutants. Given the role of AKT phosphorylation in eliciting inflammatory responses, we observed increased levels of inflammatory mediators (IL-1β, IL6, IL8, and TLR4) in AKT1-E17K cells compared to AKT1-WT cells. Treatment with AKT or HK2 inhibitors dampened the heightened levels of inflammatory markers in AKT1-E17K cells. As AKT and HK2 regulates redox homeostasis, diminished ROS generation concomitant with increased levels of NF-E2- related factor 2 (Nrf2) and superoxide dismutase 1 (SOD1) were observed in AKT1-E17K cells. Increased sensitivity of AKT1-E17K cells to AZD5363 in the presence of HK2 inhibitor Lonidamine was reversed upon treatment with ROS inhibitor NAC. By affecting metabolism, inflammation, and redox homeostasis AKT1-E17K confers a survival advantage in meningioma cells. Our findings suggest that targeting AKT-HK2 cross-talk to induce ROS-dependent cell death could be exploited as novel therapeutic approach in meningiomas., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Published
2024
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128. Macula vessel density and its relationship with the central visual field mean sensitivity across different stages of exfoliation glaucoma.

Author

Hondur G, Bayraktar S, Sen E, Kiziltoprak H, Doguizi S, and Elgin U

Subjects
Humans, Visual Fields, Cross-Sectional Studies, Retinal Vessels diagnostic imaging, Retinal Vessels pathology, Intraocular Pressure, Tomography, Optical Coherence methods, Exfoliation Syndrome diagnosis, Glaucoma, Open-Angle diagnosis
Abstract

Clinical Relevance: Alterations in ocular microvasculature may contribute to pathogenesis of exfoliation glaucoma (XFG) and may improve monitoring this aggressive type of open angle glaucoma., Background: This work aims to compare the macula vessel density and the relationship between macula vessel density and central visual field mean sensitivity between eyes with XFG and eyes with primary open-angle glaucoma (POAG) of different stages., Methods: In this cross-sectional observational study, the macula vessel density values were compared among 52 POAG cases (26 early stage, 26 moderate to advanced stage) and 53 XFG cases (27 early stage, 26 moderate to advanced stage). The vessel density values were evaluated with optical coherence tomography angiography. Vasculature-function and structure-function relationships were analysed by comparing macula vessel density, inner macula thickness and visual field mean sensitivity in early and moderate to advanced stages of XFG and POAG eyes separately., Results: The early stage XFG eyes had a significantly lower global macula vessel density compared with early stage POAG eyes (42.81 ± 3.85% and 46.56 ± 3.90%, respectively; p  = 0.02). However, the tendency of XFG eyes for a lower vessel density compared with the POAG eyes did not exhibit any significance in moderate to advanced stages of glaucoma (37.39 ± 5.65% and 38.35 ± 4.67%, respectively; p  = 0.9). The macula vessel density (%)-visual field mean sensitivity (1/Lambert) correlation was statistically significant in early stage XFG eyes ( r  = 0.464 p  = 0.01), while no such correlation was notable for the early stage POAG eyes ( r = -0.029 p  = 0.89)., Conclusion: The macula vessel density appears to be more severely affected in early stage XFG than POAG of similar severity, suggesting a relatively greater value of vascular insufficiency in XFG. The significant vasculature-function association in early stage XFG, which was absent in early stage POAG, may infer the importance of macula vessel density in monitoring functional loss in early stages of XFG.

Published
2024
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129. The real-world outcomes of Lutetium-177 PSMA-617 radioligand therapy in metastatic castration-resistant prostate cancer: Turkish Oncology Group multicenter study.

Author

Almuradova E, Seyyar M, Arak H, Tamer F, Kefeli U, Koca S, Sen E, Telli TA, Karatas F, Gokmen I, Turhal NS, Sakalar T, Ayhan M, Ekinci F, Hafizoglu E, Kahraman S, Kesen O, Unal C, Alan O, Celik S, Yekeduz E, Omur O, and Gokmen E

Subjects
Male, Humans, Retrospective Studies, Turkey, Dipeptides, Heterocyclic Compounds, 1-Ring therapeutic use, Lutetium therapeutic use, Treatment Outcome, Prostate-Specific Antigen, Prostatic Neoplasms, Castration-Resistant drug therapy, Prostatic Neoplasms, Castration-Resistant radiotherapy, Prostatic Neoplasms, Castration-Resistant metabolism
Abstract

Metastatic castration-resistant prostate cancer (mCRPC) remains a challenging condition to treat despite recent advancements. This retrospective study aimed to assess the activity and tolerability of Lutetium-177 (Lu-177) PSMA-617 radioligand therapy (RLT) in mCRPC patients across multiple cancer centers in Turkey. The study included 165 patients who received at least one cycle of Lu-177 PSMA-617 RLT, with the majority having bone metastases and undergone prior treatments. Prostate-specific antigen (PSA) levels were assessed before each treatment cycle, and the biochemical response was evaluated in accordance with the Prostate Cancer Work Group 3 Criteria. The PSA decline of ≥50% was classified as a response, while an increase of ≥25% in PSA levels was indicative of progressive disease. Neither response nor progression was considered as stable disease. The Lu-177 PSMA-617 RLT led to a significant PSA response, with 50.6% of patients achieving a >50% decrease in PSA levels. Median overall survival (OS) and progression-free survival were 13.5 and 8.2 months, respectively. Patients receiving Lu-177 PSMA-617 RLT in combination with androgen receptor pathway inhibitors (ARPIs) had a higher OS compared to those receiving Lu-177 PSMA-617 RLT alone (18.2 vs 12.3 months, P = .265). The treatment was generally well-tolerated, with manageable side effects such as anemia and thrombocytopenia. This study provides real-world evidence supporting the effectiveness and safety of Lu-177 PSMA-617 RLT in mCRPC patients, particularly when used in combination with ARPIs. These findings contribute to the growing body of evidence on the potential benefits of PSMA-targeted therapies in advanced prostate cancer., (© 2023 UICC.)

Published
2024
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130. The comparison of corneal densitometry in cases with glaucoma following childhood cataract surgery and juvenile glaucoma.

Author

Elgin U, Simsek M, Sen E, Hondur G, Bayraktar S, and Acar A

Subjects
Child, Humans, Prospective Studies, Cornea, Intraocular Pressure, Densitometry, Glaucoma, Open-Angle surgery, Aphakia, Postcataract surgery, Cataract Extraction adverse effects, Glaucoma complications, Glaucoma diagnosis, Cataract complications, Cataract diagnosis
Abstract

Purpose: To compare the corneal densitometry (CD) in pediatric cases with glaucoma following childhood cataract surgery and juvenile open-angle glaucoma (JOAG)., Methods: This prospective comparative study involved 13 eyes with JOAG, 12 eyes with pseudophakic glaucoma, 13 eyes with aphakic glaucoma, and 15 control subjects. Pentacam HR Scheimpflug corneal topography was employed to evaluate corneal thickness (CCT) and CD values., Results: The mean intraocular pressure (IOP) and CCT were significantly higher in aphakic glaucoma cases than the other groups (p = 0.001). In aphakic eyes, the mean CD values were higher in most of the anterior, center, and posterior layers of 0-2 mm, 2-6 mm, 6-10 mm, and total zones (p < 0.001 for all). In pseudophakic eyes, the mean CD values were statistically similar with that of aphakic eyes and higher than that of JOAG and control eyes in all layers of 0-2 mm zone and in anterior layer of 10-12 mm and anterior and total layers of 2-6 mm zones (p < 0.05 for all). The CD values demonstrated significant correlations with CCT values in both aphakic and pseudophakic eyes. However, a significant correlation of CD values with IOP was only demonstrated in aphakic eyes (p = 0.01 for all)., Conclusion: The probable effects of childhood cataract surgery especially aphakia might cause corneal backscatter of light and increased CD in all layers in all zones of the cornea. Increased CD values and its correlation with CCT and IOP in aphakic glaucoma eyes may be of importance in clinical management., (© 2024. The Author(s).)

Published
2024
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131. Goodwill Financial Literacy Programs Make Good Sen$e

Subjects
Business, Business, international
Abstract

(From AScribe) ROCKVILLE, Md. -- Three Goodwill agencies will each receive a $15,000 grant to expand their community financial literacy programs. Bank of America funds the grant programs - designed [...]

Published
2004

132. Goodwill Financial Literacy Programs Make Good Sen$e

Subjects
Business, Economics
Abstract

ROCKVILLE, Md., Oct. 12 (AScribe Newswire) -- Three Goodwill agencies will each receive a $15,000 grant to expand their community financial literacy programs. Bank of America funds the grant programs [...]

Published
2004

133. Medidas Agregadas de Pobreza Absoluta: A Proposta de SEN e os Desenvolvimentos Subseqüentes

Author

Maurício Eliseu Costa Romão

Subjects
Empirical data, General Computer Science, Work (electrical), Poverty, Welfare economics, Principal (computer security), Economics, Subject (philosophy)
Abstract

The objetive of this paper is to show the main development in the specilized literature on poverty related to the seminal work of Amartya Sen in aggregate measures of poverty. After reviewing the principal contributions on the subject, the text uses empirical data from Brazil to illustrate the application of the best known indices of poverty.

Published
1993

135. Development of stigma scale for women with mental illness in perinatal period, validity and reliability study.

Author

Sen E, Yazici E, Kose E, Ogur YS, and Yazici AB

Subjects
Pregnancy, Humans, Male, Female, Reproducibility of Results, Psychometrics, Prejudice, Surveys and Questionnaires, Social Stigma, Mental Disorders diagnosis
Abstract

Aim: Although there are many scales that measure stigma, there is no scale with the necessary adequacy to measure stigma in the perinatal period. The study aims to develop the stigma scale for women with mental illness in the perinatal period and test its validity and reliability., Materials and Methods: Participants were reached via patients, visitors, and hospital staff who applied to Sakarya Training and Research Hospital between 01/06/2022 and 01/12/2022. Two hundred people (female n = 134, male n = 66) aged 18-65 participated in the study and "Sociodemographic data form," "Perinatal Mental Illness Stigma Scale (PMISS)," "Social Distance Scale," and "Beliefs Towards Mental Illness Scale" were used to collect data. Data were analyzed using SPSS 22 and the AMOS 26 program., Results: The Content Validity Index of the scale items was between 0.80-1. Cronbach's alpha coefficient score of the general scale was 0.94, the "Discrimination and Prejudice" sub-dimension was 0.93, and the "Labeling" sub-dimension was 0.88. It was determined that item-total score correlations varied between 0.410 and 0.799. P value calculated < 0.05 in Barlett's test and 0.94 in the Kaiser-Meyer Olkin test. These values show that factor analysis can be applied to the scale. According to the Exploratory Factor Analysis result, the scale has a 2-factor structure, explaining 60% of the total variance. The Guttman Split-Half coefficient of the scale was 0.882, and the Spearman-Brown coefficient was 0.883. The scale was reapplied to 30 participants with an interval of three weeks. The correlation coefficient between the two measurements was 0.91, indicating that the scale satisfies the invariance principle over time., Conclusion: The PMISS is a reliable measurement tool that can be used to investigate stigma towards mental illness during the perinatal period in the Turkish population., (© 2024. The Author(s).)

Published
2024
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136. Adherence to GOLD guideline treatment recommendations among pulmonologists in Turkey

Author

Sen E, Guclu SZ, Kibar I, Ocal U, Yilmaz V, Celik O, Cimen F, Topcu F, Orhun M, Tereci H, Konya A, Ar I, and Saryal S

Subjects
Adherence, chronic obstructive pulmonary disease, Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, treatment approach, Turkey, Diseases of the respiratory system, RC705-779
Abstract

Elif Sen,1 Salih Zeki Guclu,2 Isil Kibar,3 Ulku Ocal,4 Veysel Yilmaz,5 Onur Celik,6 Filiz Cimen,7 Fusun Topcu,8 Meltem Orhun,9 Hikmet Tereci,10 Aylin Konya,11 Idilhan Ar,11 Sevgi Saryal11Department of Pulmonary Diseases, Ankara University School of Medicine, Ankara, 2Pulmonary Diseases Department, Izmir Dr Suat Seren Surgery Training and Research Hospital, Izmir, 3Pulmonary Diseases Department, Istanbul Hospital, Istanbul, 4Pulmonary Diseases Department, Adana Prof Dr Nusret Karasu Pulmonary Diseases Hospital, Adana, 5Pulmonary Diseases Department, Yedikule Pulmonary Diseases and Surgery Training and Research Hospital, Istanbul, 6Pulmonary Diseases Department, Nihat Kitapçi Pulmonary Diseases and Surgery Hospital, Erzurum, 7Pulmonary Diseases Department, Atatürk Pulmonary Diseases and Surgery Training and Research Hospital, Ankara, 8Department of Pulmonary Diseases, Dicle University School of Medicine, Diyarbakir, 9Pulmonary Diseases Department, Uskudar State Hospital, Istanbul, 10Pulmonary Diseases Department, Samsun Pulmonary Diseases and Thoracic Surgery Hospital, 11Pulmonary Diseases Department, Novartis Pharmaceuticals, Istanbul, TurkeyBackground: Low adherence to Global initiative for chronic Obstructive Lung Disease (GOLD) guideline recommendations has been reported worldwide. There has been no study on the adherence to GOLD guidelines for COPD treatment in Turkey.Objectives: To investigate the rates of adherence to GOLD 2010 guidelines for COPD treatment among pulmonologists.Design: A multi-center, cross-sectional, observational study was carried out in eleven pulmonary outpatient clinics across Turkey. Adherence to GOLD was evaluated through hospital records. Demographic and clinical data were recorded.Results: Study included 719 patients (mean age: 62.9±9.7 years; males 85.4%) of whom 16 was classified as GOLD Stage I, 238 as II, 346 as III, and 119 as IV, and only 59.5% received appropriate treatment. Rates of guideline adherence varied across GOLD stages (I, 6.3%; II, 14.7%; III, 84.4%; and IV, 84%). Causes of inappropriate therapies were overtreatment (Stage I, 100% and Stage II, 91.1%), undertreatment (Stage III, 3.3% and Stage IV, 10.9%) and lack of treatment (Stage II, 3.8%; Stage III, 2.3%; and Stage IV, 5.9%). The most preferred regimen (43.4%) was long-acting β2-agonist-inhaled corticosteroid-long-acting muscarinic antagonist. Overall, 614 patients (89%) received treatment containing inhaled corticosteroid.Conclusion: Pulmonologists in Turkey have low rates of adherence to GOLD guidelines in COPD treatment. Inappropriateness of therapies was due to overtreatment in early stages and excessive use of inhaled corticosteroid (ICS) in all disease stages.Keywords: adherence, COPD, Global initiative for chronic Obstructive Lung Disease guidelines, treatment approach, Turkey, overtreatment, inhaled corticosteroid

Published
2015

137. Influence of Upper Eyelid Surgeries on Corneal Morphology Detected with Pentacam.

Author

Acar Eser N, Serbest Ceylanoglu K, and Sen E

Subjects
Humans, Prospective Studies, Eyelids surgery, Cornea surgery, Blepharoplasty, Blepharoptosis diagnosis, Blepharoptosis surgery, Astigmatism surgery
Abstract

Purpose: To analyze the corneal morphological parameters before and one month after the upper eyelid (UE) blepharoplasty and external levator resection (ELR) for ptosis surgery., Materials and Methods: Seventy eyes of 70 patients with dermatochalasis (50 eyes) and acquired aponeurotic ptosis (AAP) (20 eyes) included in this prospective study. Detailed ophthalmologic examination was performed including the best corrected visual acuity (BCVA), slit lamp examination and dilated fundoscopy. Measurements were made before and one month after the surgeries using Pentacam. Central corneal thickness (CCT), pupil center pachymetry (PCP) and thinnest pachymetry (TP), cornea front astigmatism (AST), flat keratometry (K1), steep keratometry (K2) and mean keratometry (Km) values were evaluated., Results: Higher postoperative Km measurements were observed in dermatochalasis (p = 0.038) patients. Postoperative AST values were significantly lower in both dermatochalasis and ptosis cases (p = 0.034, p = 0.003, respectively). Increased PCP and TP were found in the AAP patients (p = 0.014, p = 0.015, respectively)., Discussion: UE blepharoplasty and ELR surgeries both lead to some significant changes on corneal structure post-operatively., Level of Evidence Iv: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 ., (© 2023. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery.)

Published
2023
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138. Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in Larval Drosophila .

Author

Mancini N, Thoener J, Tafani E, Pauls D, Mayseless O, Strauch M, Eichler K, Champion A, Kobler O, Weber D, Sen E, Weiglein A, Hartenstein V, Chytoudis-Peroudis CC, Jovanic T, Thum AS, Rohwedder A, Schleyer M, and Gerber B

Subjects
Animals, Larva physiology, Brain physiology, Smell physiology, GABAergic Neurons physiology, Interneurons, Dopamine, Reward, Mushroom Bodies physiology, Drosophila physiology, Drosophila melanogaster
Abstract

Larvae of the fruit fly Drosophila melanogaster are a powerful study case for understanding the neural circuits underlying behavior. Indeed, the numerical simplicity of the larval brain has permitted the reconstruction of its synaptic connectome, and genetic tools for manipulating single, identified neurons allow neural circuit function to be investigated with relative ease and precision. We focus on one of the most complex neurons in the brain of the larva (of either sex), the GABAergic anterior paired lateral neuron (APL). Using behavioral and connectomic analyses, optogenetics, Ca 2+ imaging, and pharmacology, we study how APL affects associative olfactory memory. We first provide a detailed account of the structure, regional polarity, connectivity, and metamorphic development of APL, and further confirm that optogenetic activation of APL has an inhibiting effect on its main targets, the mushroom body Kenyon cells. All these findings are consistent with the previously identified function of APL in the sparsening of sensory representations. To our surprise, however, we found that optogenetically activating APL can also have a strong rewarding effect. Specifically, APL activation together with odor presentation establishes an odor-specific, appetitive, associative short-term memory, whereas naive olfactory behavior remains unaffected. An acute, systemic inhibition of dopamine synthesis as well as an ablation of the dopaminergic pPAM neurons impair reward learning through APL activation. Our findings provide a study case of complex circuit function in a numerically simple brain, and suggest a previously unrecognized capacity of central-brain GABAergic neurons to engage in dopaminergic reinforcement. SIGNIFICANCE STATEMENT The single, identified giant anterior paired lateral (APL) neuron is one of the most complex neurons in the insect brain. It is GABAergic and contributes to the sparsening of neuronal activity in the mushroom body, the memory center of insects. We provide the most detailed account yet of the structure of APL in larval Drosophila as a neurogenetically accessible study case. We further reveal that, contrary to expectations, the experimental activation of APL can exert a rewarding effect, likely via dopaminergic reward pathways. The present study both provides an example of unexpected circuit complexity in a numerically simple brain, and reports an unexpected effect of activity in central-brain GABAergic circuits., (Copyright © 2023 the authors.)

Published
2023
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140. Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer.

Author

Gowda P, Patrick S, Joshi SD, Kumawat RK, and Sen E

Subjects
A549 Cells, Adenocarcinoma of Lung pathology, Anti-Inflammatory Agents therapeutic use, COVID-19 immunology, COVID-19 pathology, Cell Line, Tumor, Cytokine Receptor gp130 biosynthesis, Folate Receptor 2 biosynthesis, HMGB1 Protein antagonists & inhibitors, HMGB1 Protein metabolism, Humans, Interleukin-6 immunology, Janus Kinase 1 metabolism, Lung Neoplasms pathology, Phosphorylation drug effects, SARS-CoV-2 drug effects, STAT3 Transcription Factor metabolism, Spike Glycoprotein, Coronavirus immunology, Angiotensin-Converting Enzyme 2 metabolism, Glycyrrhizic Acid therapeutic use, Immunosuppressive Agents therapeutic use, Interleukin-6 biosynthesis, Methotrexate therapeutic use, COVID-19 Drug Treatment
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19) is associated with uncontrolled inflammatory responses. Loss of pulmonary angiotensin-converting enzyme 2 (ACE2) function has been associated with SARS-CoV-2 infection. The aberrant signalling and dysregulated inflammation characteristic of lung cancer have marked similarities with SARS-CoV-2 infection. Spearman's correlation analysis of The Cancer Genome Atlas (TCGA) datasets indicated an inverse correlation between ACE2 and IL6 in lung adenocarcinoma. qRT-PCR analysis revealed CoV-2-SRBD-mediated diminished ACE2 expression in lung cancer cells that was concomitant with increased IL6 expression. Western blot and qRT-PCR analysis suggested that treatment with methotrexate (MTx) dampened CoV-2-SRBD-mediated increase in JAK1/STAT3 phosphorylation, gp130, IL6, and folate-binding protein (FBP) expressions. MTx also rescued the diminished expression of ACE2 in CoV-2-SRBD transfected cells. As lung tissue injury in severely affected COVID-19 patients is characterised by aberrant inflammatory response, repurposing MTx as an effective therapy against critical regulators of inflammation in SARS-CoV-2 infection warrants investigation., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2022
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141. ESICM LIVES 2016: part two: Milan, Italy. 1–5 October 2016

Author

Sivakumar, S., Taccone, F. S., Desai, K. A., Lazaridis, C., Skarzynski, M., Sekhon, M., Henderson, W., Griesdale, D., Chapple, L., Deane, A., Williams, L., Strickland, R., Lange, K., Heyland, D., Chapman, M., Rowland, M. J., Garry, P., Westbrook, J., Corkill, R., Antoniades, C. A., Pattinson, K. T., Fatania, G., Strong, A. J., Myers, R. B., Lazaridis, C., Jermaine, C. M., Robertson, C. S., Rusin, C. G., Hofmeijer, J., Sondag, L., Tjepkema-Cloostermans, M. C., Beishuizen, A., Bosch, F. H., van Putten, M. J. A. M., Carteron, L., Patet, C., Solari, D., Oddo, M., Ali, M. A., Dias, C., Almeida, R., Vaz-Ferreira, A., Silva, J., Monteiro, E., Cerejo, A., Rocha, A. P., Elsayed, A. A., Abougabal, A. M., Beshey, B. N., Alzahaby, K. M., Pozzebon, S., Ortiz, A. Blandino, Cristallini, S., Lheureux, O., Brasseur, A., Vincent, J. L., Creteur, J., Taccone, F. S., Hravnak, M., Yousef, K., Chang, Y., Crago, E., Friedlander, R. M., Abdelmonem, S. A., Tahon, S. A., Helmy, T. A., Meligy, H. S., Puig, F., Dunn-Siegrist, I., Pugin, J., Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Tomar, D. S., Shafi, M., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Papakrivou, E. E., Makris, D., Manoulakas, E., Tsolaki, B., Karadodas, B., Zakynthinos, E., Garcia, I. Palacios, Martin, A. Diaz, Encinares, V. Sanchez, Ibañez, M. Pachón, Montero, J. Garnacho, Labrador, G., Cangueiro, T. Cebrero, Poulose, V., Koh, J., Kam, J. W., Yeter, H., Kara, A., Aktepe, O., Topeli, A., Tsolakoglou, I., Intas, G., Stergiannis, P., Kolaros, A. A., Chalari, E., Athanasiadou, E., Martika, A., Fildisis, G., Faivre, V., Mengelle, C., Favier, B., Payen, D., Poppe, A., Winkler, M. S., Mudersbach, E., Schreiber, J., Wruck, M. L., Schwedhelm, E., Kluge, S., Zöllner, C., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., la Torre, A. García-de, de la Torre-Prados, M. V., Tsvetanova-Spasova, T., Nuevo-Ortega, P., Rueda-Molina, C., Fernández-Porcel, A., Camara-Sola, E., Salido-Díaz, L., García-Alcántara, A., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, D. E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., Suberviola, B., Riera, J., Rellan, L., Sanchez, M., Robles, J. C., Lopez, E., Vicente, R., Miñambres, E., Santibañez, M., Le Guen, M., Moore, J., Mason, N., Windpassinger, M., Plattner, O., Mascha, E., Sessler, D. I., Research, Outcomes, Melia, U., Fontanet, J., van den Berg, J. P., Struys, M. M. R. F., Vereecke, H. E. M., Jensen, E. W., Rood, P. J. T., van de Schoor, F., van Tertholen, K., Pickkers, P., van den Boogaard, M., Beardow, Z. J., Redhead, H., Paramasivam, K., Numan, T., van den Boogaard, M., Kamper, A. M., Rood, P., Peelen, L. M., Zeman, P. M., Slooter, A. J., van Ewijk, C. E., Jacobs, G. E., Girbes, A. R. J., Myatra, S. N., Harish, M. M., Prabu, N. R., Siddiqui, S., Kulkarni, A. P., Divatia, J. V., Murbach, L. D., Leite, M. A., Osaku, E. F., Costa, C. R. L. M., Pelenz, M., Neitzke, N. M., Moraes, M. M., Jaskowiak, J. L., Silva, M. M. M., Zaponi, R. S., Abentroth, L. R. L., Ogasawara, S. M., Jorge, A. C., Duarte, P. A. D., Hernández-Sánchez, N., Sánchez-Hurtado, L. A., García-Guillen, F. J., Ñamendys-Silva, S. A., Maghsoudi, B., Emami, M., Khosravi, M. B., Zand, F., Tabatabaie, H. R., Masjedi, M., Sabetiyan, G., Mokri, A., Troubleyn, J., Diltoer, M., Jacobs, R., Nguyen, D. N., De Waele, E., De Regt, J., Honoré, P. M., Van Gorp, V., Spapen, H. D., Contreras, R. S., Toapanta, N. D., Moreno, G., Sabater, J., Torrado, H., Gonzalez, M., Marin, M., Farigola, E., Gonzalez, A., Fernandez, J., Vera, A., Gisbert, X., Juliá, C., Uya, J., Corral, L., Elias-Jones, I., Gemmell, L., MacKay, A., Randall, D., Adwaney, A., Blunden, M., Prowle, J. R., Kirwan, C. J., Thomas, N., Martin, A., Owen, H., Darwin, L., Conway, D., Atkinson, D., Sharman, M., Moore, J., Barbanti, C., Amour, J., Gaudard, P., Rozec, B., Mauriat, P., M’rini, M., Leger, P. L., Cambonie, G., Liet, J. M., Girard, C., Laroche, S., Damas, P., Assaf, Z., Loron, G., Lecourt, L., Pouard, P., Randall, D., Adwaney, A., Blunden, M., Prowle, J.R., Kirwan, C. J., Kim, S. H., Na, S., Kim, J., Oh, S. Y., Jung, C. W., Yoo, S. H., Min, S. H., Chung, E. J., Lee, H., Lee, N. J., Lee, K. W., Suh, K. S., Ryu, H. G., Marshall, D. C., Goodson, R. J., Salciccioli, J. D., Shalhoub, J., Potter, E. K., Kirk-Bayley, J., Karanjia, N. D., Forni, L. G., Creagh-Brown, B. C., Bossy, M., Nyman, M., Tailor, A., Creagh-Brown, B., D’Antini, D., Spadaro, S., Valentino, F., Sollitto, F., Cinnella, G., Mirabella, L., Calvo, F. J. Redondo, Bejarano, N., Padilla, D., Baladron, V., Villajero, P., Villazala, R., Redondo, J., Yuste, A. S., Liu, J., Shen, F., Teboul, J. L., Anguel, N., Beurton, A., Bezaz, N., Richard, C., Monnet, X., Fossali, T., Colombo, R., Ottolina, D., Rossetti, M., Mazzucco, C., Marchi, A., Porta, A., Catena, E., Tollisen, K. H., Andersen, G. Ø., Heyerdahl, F., Jacobsen, D., de Waard, M. C., Girbes, A. R. J., van IJzendoorn, M. C. O., Buter, H., Kingma, W. P., Navis, G. J., Boerma, E. C., Rulisek, J., Balik, M., Zacharov, S., Kim, H. S., Jeon, S. J., Namgung, H., Lee, E., Lee, E., Cho, Y. J., Lee, Y. J., Huang, A., Cioccari, L., Luethi, N., Mårtensson, J., Bellomo, R., Forsberg, M., Edman, G., Höjer, J., Forsberg, S., Freile, M. T. Chiquito, Hidalgo, F. N., Molina, J. A. Martinez, Lecumberri, R., Rosselló, A. Figuerola, Travieso, P. Medrano, Leon, G. Tuero, Sanchez, J. Gonzalez, Frias, L. Sahuquillo, Rosello, D. Balsells, Verdejo, J. A. Garcia, Serrano, J. A. Noria, Winterwerp, D., van Galen, T., Vazin, A., Karimzade, I., Zand, A., Ozen, E., Ekemen, S., Akcan, A., Sen, E., Yelken, B. Buyukkidan, Kureshi, N., Fenerty, L., Thibault-Halman, G., Erdogan, M., Walling, S., Green, R. S., Clarke, D. B., Briassoulis, P., Kalimeris, K., Ntzouvani, A., Nomikos, T., Papaparaskeva, K., Politi, E., Kostopanagiotou, G., Crewdson, K., Rehn, M., Weaver, A., Brohi, K., Lockey, D., Wright, S., Thomas, K., Baker, C., Mansfield, L., Stafford, V., Wade, C., Watson, G., Bryant, A., Chadwick, T., Shen, J., Wilkinson, J., Furneval, J., Henderson, A., Hugill, K., Howard, P., Roy, A., Bonner, S., Baudouin, S., Ramírez, C. Sánchez, Escalada, S. Hípola, Viera, M. A. Hernández, Santana, M. Cabrera, Balcázar, L. Caipe, Monroy, N. Sangil, Campelo, F. Artiles, Vázquez, C. F. Lübbe, Santana, P. Saavedra, Santana, S. Ruiz, Carteron, L., Patet, C., Quintard, H., Solari, D., Bouzat, P., Oddo, M., Wollersheim, T., Malleike, J., Haas, K., Carbon, N., Schneider, J., Birchmeier, C., Fielitz, J., Spuler, S., Weber-Carstens, S., Enseñat, L., Pérez-Madrigal, A., Saludes, P., Proença, L., Gruartmoner, G., Espinal, C., Mesquida, J., Huber, W., Eckmann, M., Elkmann, F., Gruber, A., Lahmer, T., Mayr, U., Herner, A., Schellnegger, R., Schneider, J., Schmid, R. M., Ayoub, W., Samy, W., Esmat, A., Battah, A., Mukhtar, S., Mongkolpun, W., Cortés, D. Orbegozo, Cordeiro, C. P. R., Vincent, J. L., Creteur, J., Funcke, S., Groesdonk, H., Saugel, B., Wagenpfeil, G., Wagenpfeil, S., Reuter, D. A., Fernandez, M. M., Fernandez, R., Magret, M., González-Castro, A., Bouza, M. T., Ibañez, M., García, C., Balerdi, B., Mas, A., Arauzo, V., Añón, J. M., Ruiz, F., Ferreres, J., Tomás, R., Alabert, M., Tizón, A. I., Altaba, S., Llamas, N., Goligher, E C., Fan, E., Herridge, M., Vorona, S., Sklar, M., Dres, M., Rittayamai, N., Lanys, A., Urrea, C., Tomlinson, G., Reid, W. D., Rubenfeld, G. D., Kavanagh, B. P., Brochard, L. J., Ferguson, N. D., Neto, A. Serpa, de Abreu, M. Gama, Pelosi, P., Schultz, M. J., Guérin, C., Papazian, L., Reignier, J., Ayzac, L., Loundou, A., Forel, J. M., Rolland-Debord, C., Bureau, C., Poitou, T., Clavel, M., Perbet, S., Terzi, N., Kouatchet, A., Similowski, T., Demoule, A., Hunfeld, N., Trogrlic, Z., Ladage, S., Osse, R. J., Koch, B., Rietdijk, W., Devlin, J., van der Jagt, M., Picetti, E., Ceccarelli, P., Mensi, F., Malchiodi, L., Risolo, S., Rossi, I., Antonini, M. V., Servadei, F., Caspani, M. L., Roquilly, A., Lasocki, S., Seguin, P., Geeraerts, T., Perrigault, P. F., Dahyot-Fizelier, C., Paugam-Burtz, C., Cook, F., Cinotti, R., dit Latte, D. Demeure, Mahe, P. J., Fortuit, C., Feuillet, F., Asehnoune, K., Marzorati, C., Spina, S., Scaravilli, V., Vargiolu, A., Riva, M., Giussani, C., Sganzerla, E., Citerio, G., Barbadillo, S., de Molina, F. J. González, Álvarez-Lerma, F., Rodríguez, A., Zakharkina, T., Martin-Loeches, I., Matamoros, S., Povoa, P., Torres, A., Kastelijn, J., Hofstra, J. J., de Jong, M., Schultz, M., Sterk, P., Artigas, A., Bos, L. J., Moreau, A. S., Martin-Loeches, I., Povoa, P., Salluh, J., Rodriguez, A., Nseir, S., de Jong, E., van Oers, J. A., Beishuizen, A., Girbes, A. R. J., Nijsten, M. W. N., de Lange, D. W., Bonvicini, D., Labate, D., Benacchio, L., Olivieri, A., Pizzirani, E., Lopez-Delgado, J. C., Gonzalez-Romero, M., Fuentes-Mila, V., Berbel-Franco, D., Romera-Peregrina, I., Martinez-Pascual, A., Perez-Sanchez, J., Abellan-Lencina, R., Ávila-Espinoza, R. E., Moreno-Gonzalez, G., Sbraga, F., Griffiths, S., Grocott, M. P. 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P., King, H. S., Chan, K. C., Yan, W. W., Londoño, J. Gonzalez, Cardenas, C. Lorencio, Pedrosa, M. Morales, Gubianas, C. Murcia, Bertolin, C. Fuster, Batllori, N. Vila, Sirvent, J. M., Wykes, K., Jack, J., Morgan, P., Mukhopadhyay, A., Chan, H. Y., Kowitlawakul, Y., Remani, D., Leong, C. S. F., Henry, C. J., Puthucheary, Z. A., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, M., Espinoza, E. D. Valenzuela, Welsh, S. P., Motta, M. F., Guerra, E., Zerpa, M. C. l., Zechner, F., Furche, M., Berdaguer, F., Birri, P. N. Rubatto, Risso-Vazquez, A., Dubin, A., Masevicius, F. D., Greaney, D., Magee, A., Fitzpatrick, G., Lugo-Cob, R. G., Sánchez-Hurtado, L. A., Arvizu-Tachiquín, P. C., Tejeda-Huezo, B. C., Cano-Oviedo, A. A., Baltazar-Torres, J. A., Aydogan, M. S., Togal, T., Taha, A., Chai, H. Z., Kam, C., Razali, S. S. Yang, Sivasamy, V., Kuan, L. Y., Poulose, V., Morales, M. A. Lopez, Castro, S., Pires, T., Melão, L., Krystopchuk, A., Pereira, I., Granja, C., Taniguchi, L. U., Pires, E. M. C., Vieira, Jr, J. M., Azevedo, L. C. P., Nurses of the Central and General ICUs of Shiraz Namazi Hospital, Sedation an Delirium Group Hospital Universitari de Bellvitge, SPACeR group (Surrey Peri-operative, Anaesthesia and Critical Care Collaborative Research Group), for the PRoVENT investigators and the PROVE Network, SEMICYUC/GETGAG Working Group, TAVeM study group, POPC-CB investigators, DESIRE (DExmedetomidine for Sepsis in ICU Randomized Evaluation) Trial Investigators, GEMINI, Bioethics work group of SEMICYUC, The FINNAKI Study Group, Queen Square Neuroanaesthesia and Neurocritical Care Resreach Group, Renal Transplantation HUVR, GEMINI, EDISVAL Group, EDISVAL Group, PLUG Working group, TAVeM study Group, The FINNAKI Study Group, on behalf of Department of Professional Development, ESICM, Critical Care Research Group, SIRAKI group, and Grupo ESBAGA

Published
2016
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143. Predicting Pneumonia Events in COPD Patients Using Medical Records

Author

Price, D.B., primary, Henley, W., additional, Carter, V., additional, Skinner, D., additional, Alexander, L., additional, Vella, R., additional, Papi, A., additional, Fabbri, L.M., additional, Kerstjens, H.A.M., additional, Roche, N., additional, Singh, D., additional, Volgemeier, C.F., additional, Sen, E., additional, Cançado, J.E.D., additional, Kots, M., additional, Nudo, E., additional, Barile, S., additional, and Georges, G., additional

Published
2022
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144. Cleft Palate Repair with Orbicularis Oris Plus Buccal Mucosal Flap: A New Double Layered-Technique.

Author

Akbulut N, Altan A, and Sen E

Abstract

Recurrent oronasal fistula closure is a challenging phenomenon that has been managed with many surgical or flap techniques, such as local, regional, and distant flaps, with various modifications. Despite these options, the ideal method to repair this kind of chronic fistula has not yet been established. It is difficult to repair because recurrent surgical repairs or interventions cause this region to become more fibrotic with less vascular tissue, which considerably reduces the likelihood of closing this kind of fistula. For this reason, surgeons and researchers continue to work to overcome these obstacles by using more regional, vascular, and neighboring tissue. Classic cleft palate repair techniques use double-layered, nasal, and oral side closure and even a three-layered technique (e.g. plus levator veli palatini and tensor veli palatini muscular repair) in the soft palate region. Hence, we used partial orbicularis oris muscle with enough vascular supply to repair the nasal side and cheek mucosal flap to repair the oral side as a double-layered repair technique. Two years later, during routine patient follow-up, no complications were identified, and the patient's satisfaction with this treatment was acceptable., Competing Interests: The authors declare that they have no conflict of interest., (Copyright: © Journal of Dentistry.)

Published
2023
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145. The influence of microorganisms on early relapses after external dacryocystorhinostomy.

Author

Acar Eser N, Ceylanoglu KS, Malkoc Sen E, and Evren E

Subjects
Humans, Prospective Studies, Recurrence, Treatment Outcome, Retrospective Studies, Dacryocystorhinostomy methods, Lacrimal Duct Obstruction, Nasolacrimal Duct surgery
Abstract

Purpose: Understanding the influence of microorganisms in patients with acquired nasolacrimal duct obstruction (NLDO) and investigating their effect on recurrence after external dacryocystorhinostomy (DCR)., Methods: This prospective study included 50 patients. Evaluations were made before, on the first postoperative day and monthly after DCR. Nasolacrimal silicon tubes (NST) were removed after three months. Before the DCR, swab samples were taken from both hands and lower conjunctival fornices and from the lacrimal sac during the first DCR and from the relapsed cases during the second DCR., Results: Growth was observed in 90 (45%) cultures out of 200 and a total of 23 different strains were identified altogether. Staphylococcus aureus (40%) and Streptococcus pneumoniae (28%) were dominantly isolated which were all resistant to penicillin, tetracycline and erythromycin. Lacrimal syringing (LS) was successful in patients (100%) on the first postoperative day. After three months, before NST removal, purulent discharge from the punctum was observed in five patients, and blockage was detected by LS. S. pneumoniae was isolated from all five patients' obstructed side conjunctival cultures. Additionally, from their lacrimal sac, S. pneumoniae (4 patients), Capnocytophaga gingivalis, and Candida spp. (1 patient) strains were isolated. S pneumoniae was isolated in four out of five patients from the ipsilateral conjunctival and lacrimal sac cultures which obtained from the subsequent DCR., Conclusion: Our results showed that S. pneumoniae was an isolated and persistent strain in cases with early recurrence even after a successful DCR., (© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)

Published
2023
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146. Reduced YAP1 and FOLR1 in gliomas predict better response to chemotherapeutics.

Author

Patrick S, Lathoria K, Suri V, and Sen E

Subjects
Humans, Interleukin-8, Temozolomide, Folate Receptor 1 genetics, Interleukin-6 metabolism, Mutation genetics, Transcription Factors metabolism, Glioma metabolism, Brain Neoplasms metabolism
Abstract

Gliomas harbouring mutations in IDH1 (isocitrate dehydrogenase 1) are characterized by greater sensitivity to chemotherapeutics. These mutants also exhibit diminished levels of transcriptional coactivator YAP1 (yes-associated protein 1). Enhanced DNA damage in IDH1 mutant cells, as evidenced by γH2AX formation (phosphorylation of histone variant H2A.X) and ATM (serine/threonine kinase; ataxia telangiectasia mutated) phosphorylation, was accompanied by reduced FOLR1 (folate receptor 1) expression. Diminished FOLR1, concomitant with heightened γH2AX levels, was also observed in patient-derived IDH1 mutant glioma tissues. Chromatin immunoprecipitation, overexpression of mutant YAP1, and treatment with YAP1-TEAD (TEA domain transcription factors) complex inhibitor verteporfin demonstrated regulation of FOLR1 expression by YAP1 and its partner transcription factor TEAD2. TCGA (The Cancer Genome Atlas) data analysis demonstrated better patient survival with reduced FOLR1 expression. Depletion of FOLR1 rendered IDH1 wild-type gliomas more susceptible to temozolomide-mediated death. Despite heightened DNA damage, IDH1 mutants exhibited reduced levels of IL6 (interleukin 6) and IL8 (interleukin 8) - pro-inflammatory cytokines known to be associated with persistent DNA damage. While both FOLR1 and YAP1 influenced DNA damage, only YAP1 was involved in regulating IL6 and IL8. ESTIMATE and CIBERSORTx analyses revealed the association between YAP1 expression and immune cell infiltration in gliomas. By identifying the influence of YAP1-FOLR1 link in DNA damage, our findings suggest that simultaneous depletion of both could amplify the potency of DNA damaging agents, while concomitantly reducing the release of inflammatory mediators and potentially affecting immune modulation. This study also highlights the novel role of FOLR1 as a probable prognostic marker in gliomas, predicting responsiveness to temozolomide and other DNA damaging agents., Competing Interests: Declaration of Competing Interest The authors declare that they have no conflicts of interest., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Published
2023
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148. PRMT1 driven PTX3 regulates ferritinophagy in glioma.

Author

Lathoria K, Gowda P, Umdor SB, Patrick S, Suri V, and Sen E

Subjects
Humans, Isocitrate Dehydrogenase genetics, Isocitrate Dehydrogenase metabolism, Isocitrate Dehydrogenase therapeutic use, Protein-Arginine N-Methyltransferases genetics, NADP, Autophagy genetics, Mutation genetics, YY1 Transcription Factor, Repressor Proteins genetics, Glioma pathology, Brain Neoplasms pathology
Abstract

Mutations in the Krebs cycle enzyme IDH1 (isocitrate dehydrogenase (NADP(+)) 1) are associated with better prognosis in gliomas. Though IDH1 mutant (IDH1 R132H ) tumors are characterized by their antiproliferative signatures maintained through hypermethylation of DNA and chromatin, mechanisms affecting cell death pathways in these tumors are not well elucidated. On investigating the crosstalk between the IDH1 mutant epigenome, ferritinophagy and inflammation, diminished expression of PRMT1 (protein arginine methyltransferase 1) and its associated asymmetric dimethyl epigenetic mark H4R3me2a was observed in IDH1 R132H gliomas. Reduced expression of PRMT1 was concurrent with diminished levels of PTX3, a key secretory factor involved in cancer-related inflammation. Lack of PRMT1 H4R3me2a in IDH1 mutant glioma failed to epigenetically activate the expression of PTX3 with a reduction in YY1 (YY1 transcription factor) binding on its promoter. Transcriptional activation and subsequent secretion of PTX3 from cells was required for maintaining macroautophagic/autophagic balance as pharmacological or genetic ablation of PTX3 secretion in wild-type IDH1 significantly increased autophagic flux. Additionally, PTX3-deficient IDH1 mutant gliomas exhibited heightened autophagic signatures. Furthermore, we demonstrate that the PRMT1-PTX3 axis is important in regulating the levels of ferritin genes/iron storage and inhibition of this axis triggered ferritinophagic flux. This study highlights the conserved role of IDH1 mutants in augmenting ferritinophagic flux in gliomas irrespective of genetic landscape through inhibition of the PRMT1-PTX3 axis. This is the first study describing ferritinophagy in IDH1 mutant gliomas with mechanistic details. Of clinical importance, our study suggests that the PRMT1-PTX3 ferritinophagy regulatory circuit could be exploited for therapeutic gains. Abbreviations: 2-HG: D-2-hydroxyglutarate; BafA 1 : bafilomycin A 1 ; ChIP: chromatin immunoprecipitation; FTH1: ferritin heavy chain 1; FTL: ferritin light chain; GBM: glioblastoma; HMOX1/HO-1: heme oxygenase 1; IHC: immunohistochemistry; IDH1: isocitrate dehydrogenase(NADP(+))1; MDC: monodansylcadaverine; NCOA4: nuclear receptor coactivator 4; NFE2L2/Nrf2: NFE2 like bZIP transcription factor 2; PTX3/TSG-14: pentraxin 3; PRMT: protein arginine methyltransferase; SLC40A1: solute carrier family 40 member 1; Tan IIA: tanshinone IIA; TCA: trichloroacetic acid; TEM: transmission electron microscopy; TNF: tumor necrosis factor.

Published
2023
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149. Evaluation of the segmented inner retinal layers in exfoliation glaucoma.

Author

Hondur G, Sen E, Bayraktar S, Ozkoyuncu Kocabas D, Elgin U, and Tezel G

Subjects
Humans, Retinal Ganglion Cells, Cross-Sectional Studies, Prospective Studies, Retina diagnostic imaging, Tomography, Optical Coherence methods, Exfoliation Syndrome diagnosis
Abstract

Purpose: To investigate the macular spectral domain optical coherence tomography (SD-OCT) measurements of the segmented inner retinal layers in patients with exfoliation syndrome (XFS), exfoliation glaucoma (XFG)., Methods: This prospective cross-sectional study included 28 eyes with XFS, 47 eyes with XFG, and 29 healthy controls. Thickness of the inner retinal layers, including retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) was obtained from the horizontal SD-OCT scans. Functional correlation of structural parameters was analyzed using the mean sensitivity (MS) values on 10-2 visual fields., Results: The RNFL, GCL, and IPL were thinnest in eyes with XFG. Among these retinal layers, IPL was significantly thinner in eyes with XFS than healthy controls (p = 0.02) and the IPL thickness was significantly correlated with the corresponding MS scores on 10-2 visual fields (r = 0.492, p = 0.02) in eyes with XFS. Neither GCL nor RNFL thickness values demonstrated significant correlations with functional parameters in eyes with XFS (r = 0.377, p = 0.08; r = 0.212, p = 0.34). In eyes with XFG, the IPL thickness correlated with the visual field MS scores (r = 0.572, p = 0.0007), similar to the correlation of GCL (r = 0.585, p = 0.0005) thickness with visual field scores., Conclusions: Segmented analysis of the macular IPL thickness presented a significant correlation with the 10-2 visual field scores not only in eyes with XFG but also in eyes with XFS. With respect to early dendritic/synaptic alterations in animal models, larger and longitudinal studies are encouraged to determine the predictive value of the IPL thickness for conversion of XFS to XFG., (© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)

Published
2023
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150. Reliability and validity of the brief version of the difficulties in emotion regulation scale in a sample of Turkish adolescents.

Author

Demirpence Secinti D and Sen E

Subjects
Humans, Adolescent, Reproducibility of Results, Emotions, Affective Symptoms diagnosis, Affective Symptoms psychology, Surveys and Questionnaires, Psychometrics, Emotional Regulation
Abstract

Background: Difficulty in regulating emotions increases during adolescence and can be associated with psychopathology. It is thus crucial to develop tools to identify adolescents at risk of having emotional difficulties. This study aimed to investigate the reliability and validity of a brief questionnaire in a sample of Turkish adolescents., Methods: A total of 256 participants (mean age = 15.51 ± 0.85) were recruited. They completed the original form of the Difficulties in Emotion Regulation Scale (DERS-36), a brief version of DERS (DERS-16), the Barrett Impulsivity Scale (BIS-11), and the Toronto Alexithymia Scale (TAS). Psychometric properties of DERS-16 were investigated by confirmatory factor analysis, Cronbach's alpha, and Pearson correlational analysis., Results: A five-factor model and second-order bifactor model of DERS-16 were confirmed. Cronbach's alpha values for the subscales varied between 0.69 and 0.88, while the reliability of the factors Difficulties in Emotional Processing and Difficulties in Emotion Regulation were 0.75 and 0.90, respectively. DERS-16 subscales were positively correlated with the BIS-11 and TAS. In addition, there were only minimal differences between the DERS-16 and DERS-36., Conclusion: The DERS-16 is a valid and reliable scale for Turkish adolescents. The fact that it has fewer items than DERS-36, but has similar reliability and validity and can be used as two factors, provides significant advantages in terms of applicability., (© 2023. The Author(s).)

Published
2023
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