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104. Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue

Author

Gallego-Perez, Daniel, Pal, Durba, Ghatak, Subhadip, Malkoc, Veysi, Higuita-Castro, Natalia, Gnyawali, Surya, Chang, Lingqian, Liao, Wei-Ching, Shi, Junfeng, Sinha, Mithun, Singh, Kanhaiya, Steen, Erin, Sunyecz, Alec, Stewart, Richard, Moore, Jordan, Ziebro, Thomas, Northcutt, Robert G., Homsy, Michael, Bertani, Paul, Lu, Wu, Roy, Sashwati, Khanna, Savita, Rink, Cameron, Sundaresan, Vishnu Baba, Otero, Jose J., Lee, L. James, and Sen, Chandan K.

Published
2017
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116. Epigenetic basis of diabetic vasculopathy

Author

Bhamidipati, Theja, Kumar, Manishekhar, Verma, Sumit S., Mohanty, Sujit K., Kacar, Sedat, Reese, Diamond, Martinez, Michelle M., Kamocka, Malgorzata M., Dunn, Kenneth W., Sen, Chandan K., and Singh, Kanhaiya

Subjects
Diabetes Mellitus, Type 2, Endocrinology, Diabetes and Metabolism, Humans, Vascular Diseases, DNA Methylation, Diabetic Angiopathies, Epigenesis, Genetic
Abstract

Type 2 diabetes mellitus (T2DM) causes peripheral vascular disease because of which several blood-borne factors, including vital nutrients fail to reach the affected tissue. Tissue epigenome is sensitive to chronic hyperglycemia and is known to cause pathogenesis of micro- and macrovascular complications. These vascular complications of T2DM may perpetuate the onset of organ dysfunction. The burden of diabetes is primarily because of a wide range of complications of which nonhealing diabetic ulcers represent a major component. Thus, it is imperative that current research help recognize more effective methods for the diagnosis and management of early vascular injuries. This review addresses the significance of epigenetic processes such as DNA methylation and histone modifications in the evolution of macrovascular and microvascular complications of T2DM.

Published
2022
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119. List of Contributors

Author

Ambalam, Padma, primary, Antonicelli, Frank, additional, Asrafuzzaman, Syed, additional, Bagchi, Debasis, additional, Bernard, Philippe, additional, Bhakkiyalakshmi, Elango, additional, Biswas, Chhanda, additional, Bonesi, Marco, additional, Bosco, Nabil, additional, Cexus, Olivier, additional, Chaffee, Scott, additional, Chatterjee, Shampa, additional, Cheong, Dorothy H.J., additional, Choe, Sung J., additional, Das, Amitava, additional, De Meester, Ingrid, additional, Del Rosario, Fernando, additional, Dholia, Neeraj, additional, Doble, Mukesh, additional, Falasca, Katia, additional, Ganguly, Koustav, additional, George, Leema, additional, Ghosh, Nandini, additional, Grimes, Catherine L., additional, He, Zhaoping, additional, Hood, Elizabeth D., additional, Howes, Melanie-Jayne R., additional, Hussain, Shaik Abdul, additional, Jeong, Se K., additional, Jungraithmayr, Wolfgang, additional, Kabuki, Toshihide, additional, Kawasaki, Yoshihiro, additional, Kothari, Charmy, additional, Larbi, Anis, additional, Le Jan, Sébastien, additional, Lee, Eun-Ji, additional, Lee, Jeong-Sang, additional, Lee, Robert J., additional, Lim, Chae J., additional, Loizzo, Monica R., additional, Menichini, Francesco, additional, Mallilankaraman, Karthik B., additional, Manoj Kumar Kingsley, Selvaraj, additional, McMahon, Derek B., additional, Melnyk, James E., additional, Moriya, Tomohiro, additional, Moyes, David L., additional, Na, Hye-Kyung, additional, Nair, Pradeep M.K., additional, Nishihira, Jun, additional, Nishimura, Mie, additional, Park, Keedon, additional, Park, Kyungho, additional, Patel, Priyal, additional, Peethambaran, Bela, additional, Pithva, Sheetal, additional, Plée, Julie, additional, Pothuraju, Ramesh, additional, Prasad, Nupoor, additional, Purama, Ravi Kiran, additional, Qiao, Yongkang, additional, Raman, Maya, additional, Ramkumar, Kunka M., additional, Ramteke, Prerna, additional, Reale, Marcella, additional, Roy, Sashwati, additional, Sakai, Fumihiko, additional, Salwa, Hyndavi, additional, Sampath, Venkatesh, additional, Schaefer, Amy K., additional, Sen, Chandan K., additional, Shah, Rahul, additional, Sharma, Ashish K., additional, Sharma, Minaxi, additional, Sifers, Travis M., additional, Simes, Dina C., additional, Sireesh, Dornadula, additional, Surh, Young-Joon, additional, Thimraj, Tania A., additional, Tran, Thai, additional, Tundis, Rosa, additional, Upadhyay, Swapna, additional, Vazquez-Medina, Jose P., additional, Viegas, Carla S.B., additional, Vishnu Bhat, Ballambattu, additional, Vliegen, Gwendolyn, additional, Witherden, Elizabeth A., additional, Yadav, Umesh C.S., additional, Yenuganti, Vengala Rao, additional, and You, Huihui, additional

Published
2018
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132. Tissue nanotransfection causes tumor regression by its effect on nanovesicle cargo that alters microenvironmental macrophage state

Author

Gordillo, Gayle M., primary, Guda, Poornachander Reddy, additional, Singh, Kanhaiya, additional, Biswas, Ayan, additional, Abouhashem, Ahmed S., additional, Rustagi, Yashika, additional, Sen, Abhishek, additional, Kumar, Manishekhar, additional, Das, Amitava, additional, Ghatak, Subhadip, additional, Khanna, Savita, additional, Sen, Chandan K., additional, and Roy, Sashwati, additional

Published
2022
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134. The NIDDK Diabetic Foot Consortium

Author

Jones, Teresa L.Z., primary, Holmes, Crystal M., additional, Katona, Aimee, additional, Martin, Catherine L., additional, Niewczas, Monika A., additional, Pop-Busui, Rodica, additional, Schmidt, Brian M., additional, Sen, Chandan K., additional, Tomic-Canic, Marjana, additional, and Veves, Aristidis, additional

Published
2022
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135. Electrochemical Devices in Cutaneous Wound Healing.

Author

Evans, J. Parker and Sen, Chandan K.

Subjects
*WOUND healing, *SKIN injuries, *CLINICAL trials, *HEALING, *DIABETIC foot
Abstract

In healthy skin, vectorial ion transport gives rise to a transepithelial potential which directly impacts many physiological aspects of skin function. A wound is a physical defect that breaches the epithelial barrier and changes the electrochemical environment of skin. Electroceutical dressings are devices that manipulate the electrochemical environment, host as well as microbial, of a wound. In this review, electroceuticals are organized into three mechanistic classes: ionic, wireless, and battery powered. All three classes of electroceutical dressing show encouraging effects on infection management and wound healing with evidence of favorable impact on keratinocyte migration and disruption of wound biofilm infection. This foundation sets the stage for further mechanistic as well as interventional studies. Successful conduct of such studies will determine the best dosage, timing, and class of stimulus necessary to maximize therapeutic efficacy. [ABSTRACT FROM AUTHOR]

Published
2023
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139. Contributors

Author

Appelhans, Kristy, primary, Atwater, Margie, additional, Baruah, Kartik, additional, Batzer, Brent, additional, Bessonov, Vladimir, additional, Bogue, Joe, additional, Bragazzi, Nicola Luigi, additional, Cao, Joyce, additional, Di Capua, Annamaria, additional, Carrera, George, additional, Chaffee, Scott, additional, Chong, Leighton K., additional, Collins, Orla, additional, Cwik, Joseph, additional, Das, Amitava, additional, Datta, Sourya, additional, Dickerson, Ryan, additional, Downs, Bernard W., additional, Erz, Antonia, additional, Gautam, Surya P., additional, Ghosh, Mahua, additional, Gianfredi, Vincenza, additional, Gupta, Surashree Sen, additional, Gurnani, Abhishek, additional, Hilton, Jeff, additional, Hoadley, James E., additional, Hu, Chun, additional, Hudson, John, additional, Isakov, Vasily, additional, Jackson, Michelle, additional, Keservani, Raj K., additional, Kesharwani, Rajesh K., additional, Klesh, Kristen, additional, Kochetkova, Alla, additional, Kuler, Jacqueline, additional, Lewis, Claudia, additional, Maddalo, Francesco, additional, Marensi, Lorenzo, additional, Marone, Palma Ann, additional, Martini, Mariano, additional, McDonald, Shane T., additional, Moskowitz, David, additional, Moskowitz, Howard, additional, Norouzitallab, Parisa, additional, Nucci, Daniele, additional, Pal, Asim Kumar, additional, Poliner, Matthew, additional, Porretta, Sebastiano, additional, Rappaport, Stephen, additional, Rossi, Livia, additional, Roy, Sashwati, additional, Saporita, Teresa Concetta, additional, Sarkisyan, Varuzhan, additional, Sen, Chandan K., additional, Shao, Andrew, additional, Sharma, Anil K., additional, Shield, Jennifer, additional, Smirnova, Elena, additional, Tollin, Karin, additional, Tovani, Flavio, additional, Troy, Amy Jane, additional, Tutelyan, Victor, additional, Udell, Lawrence J., additional, Vej, Jesper, additional, Velema, Brigitte, additional, Verma, Santosh K., additional, Vukasović, Tina, additional, and Zawistowski, Jerzy, additional

Published
2017
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143. Oral Tocotrienols Are Transported to Human Tissues and Delay the Progression of the Model for End-Stage Liver Disease Score in Patients 4

Author

Patel, Viren, Rink, Cameron, Gordillo, Gayle M., Khanna, Savita, Gnyawali, Urmila, Roy, Sashwati, Shneker, Bassel, Ganesh, Kasturi, Phillips, Gary, More, J. Layne, Sarkar, Atom, Kirkpatrick, Robert, Elkhammas, Elmahdi A., Klatte, Emily, Miller, Michael, Firstenberg, Michael S., Chiocca, E. Antonio, Nesaretnam, Kalanithi, and Sen, Chandan K.

Published
2012
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146. Analysis of Keratinocytic Exosomes from Diabetic and Nondiabetic Mice by Charge Detection Mass Spectrometry

Author

Brown, Brooke A., primary, Guda, Poornachander R., additional, Zeng, Xuyao, additional, Anthony, Adam, additional, Couse, Andrew, additional, Barnes, Lauren F., additional, Sharon, Edie M., additional, Trinidad, Jonathan C., additional, Sen, Chandan K., additional, Jarrold, Martin F., additional, Ghatak, Subhadip, additional, and Clemmer, David E., additional

Published
2022
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147. Filamentous bacteriophage delays healing of Pseudomonas-infected wounds

Author

Bach, Michelle S., primary, de Vries, Christiaan R., additional, Khosravi, Arya, additional, Sweere, Johanna M., additional, Popescu, Medeea C., additional, Chen, Qingquan, additional, Demirdjian, Sally, additional, Hargil, Aviv, additional, Van Belleghem, Jonas D., additional, Kaber, Gernot, additional, Hajfathalian, Maryam, additional, Burgener, Elizabeth B., additional, Liu, Dan, additional, Tran, Quynh-Lam, additional, Dharmaraj, Tejas, additional, Birukova, Maria, additional, Sunkari, Vivekananda, additional, Balaji, Swathi, additional, Ghosh, Nandini, additional, Mathew-Steiner, Shomita S., additional, El Masry, Mohamed S., additional, Keswani, Sundeep G., additional, Banaei, Niaz, additional, Nedelec, Laurence, additional, Sen, Chandan K., additional, Chandra, Venita, additional, Secor, Patrick R., additional, Suh, Gina A., additional, and Bollyky, Paul L., additional

Published
2022
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