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101. The present status of commercialized and developed biotech (GM) crops, results of evaluation of plum 'Honeysweet' for resistance to plant viruses in the Czech Republic

Author

Polak, J., Kumar, J., Krska, B., Ravelonandro, Michel, Scorza, R., Crop research institute, Faculty of Horticulture in Lednice, Mendel University in Brno (MENDELU), Biologie du fruit et pathologie (BFP), Université Sciences et Technologies - Bordeaux 1-Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), United States Department of Agriculture (USDA), and ProdInra, Migration

Subjects
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], [SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

102. Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up

Author

Martin, J.E., Broen, J.C., Carmona, F.D., Teruel, M., Simeon, C.P., Vonk, M.C., Slot, R. van 't, Rodriguez-Rodriguez, L., Vicente, E., Fonollosa, V., Ortego-Centeno, N., Gonzalez-Gay, M.A., Garcia-Hernandez, F.J., Pena, P.G. de la, Carreira, P., Voskuyl, A.E., Schuerwegh, A.J., Riel, P.L.C.M. van, Kreuter, A., Witte, T., Riemekasten, G., Airo, P., Scorza, R., Lunardi, C., Hunzelmann, N., Distler, J.H.W., Beretta, L., Laar, J. van, Chee, M.M., Worthington, J., Herrick, A., Denton, C., Tan, F.K., Arnett, F.C., Assassi, S., Fonseca, C., Mayes, M.D., Radstake, T.R.D.J., Koeleman, B.P.C., Martin, J., Spanish Schleroderma Grp, Rheumatology, and CCA - Disease profiling

Subjects
Genotype, systemic sclerosis, GSK gene, Locus (genetics), Single-nucleotide polymorphism, Genome-wide association study, Biology, Systemic scleroderma, Polymorphism, Single Nucleotide, CSK Tyrosine-Protein Kinase, Cohort Studies, Meta-Analysis as Topic, Risk Factors, GWAS, Genetics, medicine, Odds Ratio, Humans, Genetic Predisposition to Disease, Genetic risk, Molecular Biology, Gene, Genetics (clinical), Autoimmune disease, Scleroderma, Systemic, Association Studies Articles, NF-kappa B p50 Subunit, General Medicine, Odds ratio, Protein-Tyrosine Kinases, medicine.disease, beta Karyopherins, Infection and autoimmunity Auto-immunity, transplantation and immunotherapy [NCMLS 1], Europe, src-Family Kinases, Interferon Regulatory Factors, Evaluation of complex medical interventions Auto-immunity, transplantation and immunotherapy [NCEBP 2], Follow-Up Studies, Genome-Wide Association Study
Abstract

Systemic sclerosis (SSc) is complex autoimmune disease affecting the connective tissue; influenced by genetic and environmental components. Recently, we performed the first successful genome-wide association study (GWAS) of SSc. Here, we perform a large replication study to better dissect the genetic component of SSc. We selected 768 polymorphisms from the previous GWAS and genotyped them in seven replication cohorts from Europe. Overall significance was calculated for replicated significant SNPs by meta-analysis of the replication cohorts and replication-GWAS cohorts (3237 cases and 6097 controls). Six SNPs in regions not previously associated with SSc were selected for validation in another five independent cohorts, up to a total of 5270 SSc patients and 8326 controls. We found evidence for replication and overall genome-wide significance for one novel SSc genetic risk locus: CSK [P-value 5 5.04 3 10 -12, odds ratio (OR) 5 1.20]. Additionally, we found suggestive association in the loci PSD3 (P-value 5 3.18 3 10 -7, OR 5 1.36) and NFKB1 (P-value 5 1.03 3 10 -6, OR5 1.14). Additionally, we strengthened the evidence for previously confirmed associations. This study significantly increases the number of known putative genetic risk factors for SSc, including the genes CSK, PSD3 and NFKB1, and further confirms six previously described ones. © The Author 2012. Published by Oxford University Press. All rights reserved.

Published
2012

103. A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations

Author

Bossini-Castillo, L., Martin, J.E., Broen, J., Gorlova, O., Simeon, C.P., Beretta, L., Vonk, M.C., Callejas, J.L., Castellvi, I., Carreira, P., Garcia-Hernandez, F.J., Castro, M.F., Coenen, M.J.H., Riemekasten, G., Witte, T., Hunzelmann, N., Kreuter, A., Distler, J.H.W., Koeleman, B.P., Voskuyl, A.E., Schuerwegh, A.J., Palm, O., Hesselstrand, R., Nordin, A., Airo, P., Lunardi, C., Scorza, R., Shiels, P., Laar, J.M. van, Herrick, A., Worthington, J., Denton, C., Tan, F.K., Arnett, F.C., Agarwal, S.K., Assassi, S., Fonseca, C., Mayes, M.D., Radstake, T.R.D.J., Martin, J., Spanish Scleroderma Grp, Rheumatology, and CCA - Immuno-pathogenesis

Subjects
medicine.medical_specialty, SNP, Single-nucleotide polymorphism, Genome-wide association study, Locus (genetics), Systemic Sclerosis, Biology, Polymorphism, Single Nucleotide, White People, Genetics, medicine, Humans, GWAS, Genetic Predisposition to Disease, Genomic disorders and inherited multi-system disorders Molecular epidemiology [IGMD 3], Molecular Biology, Genetics (clinical), Genetic association, Scleroderma, Systemic, Association Studies Articles, Receptors, Interleukin-12, General Medicine, Odds ratio, Infection and autoimmunity Auto-immunity, transplantation and immunotherapy [NCMLS 1], United States, Europe, Cohort, Evaluation of complex medical interventions Auto-immunity, transplantation and immunotherapy [NCEBP 2], Medical genetics, Follow-Up Studies, Genome-Wide Association Study
Abstract

A single-nucleotide polymorphism (SNP) at the IL12RB2 locus showed a suggestive association signal in a previously published genome-wide association study (GWAS) in systemic sclerosis (SSc). Aiming to reveal the possible implication of the IL12RB2 gene in SSc, we conducted a follow-up study of this locus in different Caucasian cohorts. We analyzed 10 GWAS-genotyped SNPs in the IL12RB2 region (2309 SSc patients and 5161 controls). We then selected three SNPs (rs3790567, rs3790566 and rs924080) based on their significance level in the GWAS, for follow-up in an independent European cohort comprising 3344 SSc and 3848 controls. The most-associated SNP (rs3790567) was further tested in an independent cohort comprising 597 SSc patients and 1139 controls from the USA. After conditional logistic regression analysis of the GWAS data, we selected rs3790567 [PMH5 1.92 3 10 -5 odds ratio (OR) 5 1.19] as the genetic variant with the firmest independent association observed in the analyzedGWASpeak of association. After the first follow-up phase, only the association of rs3790567 was consistent (PMH5 4.84 3 10 -3OR 5 1.12). The second follow-up phase confirmed this finding (Px2 5 2.82 3 10 -4 OR 5 1.34). After performing overall pooled-analysis of all the cohorts included in the present study, the association found for the rs3790567 SNP in the IL12RB2 gene region reached GWAS-level significant association (PMH5 2.82 3 10 -9 OR 5 1.17). Our data clearly support the IL12RB2 genetic association with SSc, and suggest a relevant role of the interleukin 12 signaling pathway in SSc pathogenesis. © The Author 2011. Published by Oxford University Press. All rights reserved.

Published
2012

104. Brief Report: Successful pregnancies but a higher riskof preterm births in patients with systemic sclerosis: An Italian multicenterstudy

Author

Taraborelli, M, Ramoni, V, Brucato, A, Airò, P, Bajocchi, G, Bellisai, F, Biasi, D, Blagojevic, J, Canti, V, Caporali, R, Caramaschi, P, Chiarolanza, I, Codullo, V, Cozzi, Franco, Cuomo, G, Cutolo, M, De Santis, M, De Vita, S, Di Poi, E, Doria, Andrea, Faggioli, P, Favaro, M, Ferraccioli, G, Ferri, C, Foti, R, Gerosa, A, Gerosa, M, Giacuzzo, S, Giani, L, Giuggioli, D, Imazio, M, Iudici, M, Iuliano, A, Leonardi, R, Limonta, M, Lojacono, A, Lubatti, C, Matucci Cerinic, M, Mazzone, A, Meroni, M, Meroni, Pl, Mosca, M, Motta, M, Muscarà, M, Nava, S, Padovan, M, Pagani, G, Paolazzi, G, Peccatori, S, Ravagnani, V, Riccieri, V, Rosato, E, Rovere Querini, P, Salsano, F, Santaniello, A, Scorza, R, Tani, C, Valentini, G, Valesini, G, Vanoli, M, Vigone, B, Zeni, S, and Tincani, A.

Published
2012

105. Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression

Author

Broen, J.C., Dieude, P., Vonk, M.C., Beretta, L., Carmona, F.D., Herrick, A., Worthington, J., Hunzelmann, N., Riemekasten, G., Kiener, H., Scorza, R., Simeon, C.P., Fonollosa, V., Spanish Systemic Sclerosis, G., Carreira, P., Ortego-Centeno, N., Gonzalez-Gay, M.A., Airo, P., Coenen, M.J., Tsang, K., Aliprantis, A.O., Martin, J., Allanore, Y., and Radstake, T.R.

Subjects
Adult, Myeloid, Genotype, Immunology, Gene Expression, Single-nucleotide polymorphism, Rheumatology, Gene expression, Immunology and Allergy, Medicine, SNP, Humans, Genetic Predisposition to Disease, Receptor, skin and connective tissue diseases, Genomic disorders and inherited multi-system disorders Molecular epidemiology [IGMD 3], Interleukin 4, Aged, Interleukin-13, Polymorphism, Genetic, Scleroderma, Systemic, business.industry, Receptors, Interleukin-13, Interleukin-4 Receptor alpha Subunit, Middle Aged, Infection and autoimmunity Auto-immunity, transplantation and immunotherapy [NCMLS 1], Europe, medicine.anatomical_structure, Interleukin 13, Evaluation of complex medical interventions Auto-immunity, transplantation and immunotherapy [NCEBP 2], Female, Interleukin-4, business
Abstract

Objective.Polymorphisms in the genes encoding interleukin 4 (IL4), interleukin 13 (IL13), and their corresponding receptors have been associated with multiple immune-mediated diseases. Our aim was to validate these previous observations in patients with systemic sclerosis (SSc) and scrutinize the effect of the polymorphisms on gene expression in various populations of peripheral blood leukocytes.Methods.We genotyped a cohort of 2488 patients with SSc and 2246 healthy controls from The Netherlands, Spain, United Kingdom, Italy, Germany, and France. Taqman assays were used to genotype single-nucleotide polymorphisms (SNP) in the following genes: (1) IL4 (−590C>T/rs2243250); (2) IL4 receptor alpha (IL4RA) (Q576R/rs1801275); (3) IL13 (R130Q/rs20541 and −1112C>T/rs1800925); and (4) IL13RA1 (43163G>A/rs6646259). The effect of these polymorphisms on expression of the corresponding genes was assessed using quantitative RT-PCR on RNA derived from peripheral blood B cells, T cells, plasmacytoid dendritic cells, monocytes, and myeloid dendritic cells. We investigated whether these polymorphisms influenced development of pulmonary complications over 15 years in patients with SSc.Results.None of the investigated polymorphisms was associated with SSc or any SSc clinical subtype. We did not observe any effect on transcript levels in the cell subtypes or on development of pulmonary complications.Conclusion.Our data showed that polymorphisms in IL4, IL13, and their receptors do not play a role in SSc and do not influence the expression of their corresponding transcript in peripheral blood cells.

Published
2012

107. Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy

Author

Gorlova, O., Martin, J.E., Rueda, B., Koeleman, B.P.C., Ying, J., Teruel, M., Diaz-Gallo, L.M., Broen, J.C., Vonk, M.C., Simeon, C.P., Alizadeh, B.Z., Coenen, M.J.H., Voskuyl, A.E., Schuerwegh, A.J., Riel, P.L.C.M. van, Vanthuyne, M., van't Slot, R., Italiaander, A., Ophoff, R.A., Hunzelmann, N., Fonollosa, V., Ortego-Centeno, N., Gonzalez-Gay, M.A., Garcia-Hernandez, F.J., Gonzalez-Escribano, M.F., Airo, P., Laar, J. van, Worthington, J., Hesselstrand, R., Smith, V., Keyser, F. de, Houssiau, F., Chee, M.M., Madhok, R., Shiels, P.G., Westhovens, R., Kreuter, A., Baere, E. de, Witte, T., Padyukov, L., Nordin, A., Scorza, R., Lunardi, C., Lie, B.A., Hoffmann-Vold, A.M., Palm, O., Pena, P.G. de la, Carreira, P., Varga, J., Hinchcliff, M., Lee, A.T., Gourh, P., Amos, C.I., Wigley, F.M., Hummers, L.K., Hummers, J., Nelson, J.L., Riemekasten, G., Herrick, A., Beretta, L., Fonseca, C., Denton, C.P., Gregersen, P.K., Agarwal, S., Assassi, S., Tan, F.K., Arnett, F.C., Radstake, T.R.D.J., Mayes, M.D., Martin, J., Spanish Scleroderma Grp, Rheumatology, Human genetics, CCA - Disease profiling, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, UCL - (MGD) Service de rhumatologie, and McCarthy, Mark I

Subjects
Oncology, Male, Cancer Research, systemic sclerosis, Genome-wide association study, SUSCEPTIBILITY, FUNCTIONAL POLYMORPHISM, Genètica mèdica, STAT4, 0302 clinical medicine, HLA Antigens, SCLERODERMA, IRF5, 2.1 Biological and endogenous factors, Aetiology, skin and connective tissue diseases, Genetics (clinical), Genetics, 0303 health sciences, Medical genetics, Translational research Immune Regulation [ONCOL 3], Single Nucleotide, Middle Aged, Infection and autoimmunity Auto-immunity, transplantation and immunotherapy [NCMLS 1], 3. Good health, Phenotype, genome-wide association study, Evaluation of complex medical interventions Auto-immunity, transplantation and immunotherapy [NCEBP 2], Medicine, ALOPECIA-AREATA, Female, Research Article, Genetic Markers, medicine.medical_specialty, Spanish Scleroderma Group, lcsh:QH426-470, functional polymorphism japanese population pulmonary-fibrosis signaling pathways alopecia-areata risk-factor susceptibility scleroderma stat4 irf5, Single-nucleotide polymorphism, Locus (genetics), Human leukocyte antigen, Biology, Autoimmune Disease, Polymorphism, Single Nucleotide, SIGNALING PATHWAYS, 03 medical and health sciences, Clinical Research, RISK-FACTOR, Internal medicine, medicine, Genetic predisposition, Humans, Genetic Predisposition to Disease, JAPANESE POPULATION, Allele, Polymorphism, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Alleles, 030304 developmental biology, Autoantibodies, Rheumatology and Autoimmunity, 030203 arthritis & rheumatology, Scleroderma, Systemic, PULMONARY-FIBROSIS, Inflammatory and immune system, Systemic, Human Genome, Biology and Life Sciences, lcsh:Genetics, Meta-analysis, Scleroderma (Disease), Genetic marker, Genetic Loci, Clinical Immunology, Esclerodèrmia, Metaanàlisi, Developmental Biology, Genome-Wide Association Study
Abstract

The aim of this study was to determine, through a genome-wide association study (GWAS), the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc). We considered limited (lcSSc) and diffuse (dcSSc) cutaneous involvement, and the relationships with presence of the SSc-specific auto-antibodies, anti-centromere (ACA), and anti-topoisomerase I (ATA). Four GWAS cohorts, comprising 2,296 SSc patients and 5,171 healthy controls, were meta-analyzed looking for associations in the selected subgroups. Eighteen polymorphisms were further tested in nine independent cohorts comprising an additional 3,175 SSc patients and 4,971 controls. Conditional analysis for associated SNPs in the HLA region was performed to explore their independent association in antibody subgroups. Overall analysis showed that non-HLA polymorphism rs11642873 in IRF8 gene to be associated at GWAS level with lcSSc (P = 2.32×10−12, OR = 0.75). Also, rs12540874 in GRB10 gene (P = 1.27 × 10−6, OR = 1.15) and rs11047102 in SOX5 gene (P = 1.39×10−7, OR = 1.36) showed a suggestive association with lcSSc and ACA subgroups respectively. In the HLA region, we observed highly associated allelic combinations in the HLA-DQB1 locus with ACA (P = 1.79×10−61, OR = 2.48), in the HLA-DPA1/B1 loci with ATA (P = 4.57×10−76, OR = 8.84), and in NOTCH4 with ACA P = 8.84×10−21, OR = 0.55) and ATA (P = 1.14×10−8, OR = 0.54). We have identified three new non-HLA genes (IRF8, GRB10, and SOX5) associated with SSc clinical and auto-antibody subgroups. Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies. These data emphasize the differential genetic components of subphenotypes of SSc., Author Summary Scleroderma or systemic sclerosis is a complex autoimmune disease affecting one individual of every 100,000 in Caucasian populations. Even though current genetic studies have led to better understanding of the pathogenesis of the disease, much remains unknown. Scleroderma is a heterogeneous disease, which can be subdivided according to different criteria, such as the involvement of organs and the presence of specific autoantibodies. Such subgroups present more homogeneous genetic groups, and some genetic associations with these manifestations have already been described. Through reanalysis of a genome-wide association study data, we identify three novel genes containing genetic variations which predispose to subphenotypes of the disease (IRF8, GRB10, and SOX5). Also, we better characterize the patterns of associated loci found in the HLA region. Together, our findings lead to a better understanding of the genetic component of scleroderma.

Published
2011

108. Biotechnological approaches for resistance to viruses, viroids, and phytoplasmas

Author

Ravelonandro, Michel, Scorza, R., Hammond, R.W., ProdInra, Migration, Ahmed Hadidi (Editeur), Marina Barba (Editeur), Thierry Candresse (Editeur), Wilhelm Jelkmann (Editeur), Biologie du fruit et pathologie (BFP), Université Sciences et Technologies - Bordeaux 1-Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), and United States Department of Agriculture (USDA)

Subjects
[SDV] Life Sciences [q-bio], BIOTECHNOLOGIE, [SDV]Life Sciences [q-bio], SECURITE ENVIRONNEMENTALE, BIOLOGIE MOLECULAIRE, GENETIQUE, CONTROLE, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

109. Corrigendum: Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus

Author

Radstake, T.R.D.J., Gorlova, O., Rueda, B., Martin, J.E., Alizadeh, B.Z., Palomino-Morales, R., Coenen, M., Vonk, M.C., Voskuyl, A.E., Schuerwegh, A.J., Broen, J.C.A., Riel, P.L.C.M. van, Slot, R. van 't, Italiaander, A., Ophoff, R.A., Riemekasten, G., Hunzelmann, N., Simeon, C.P., Ortego-Centeno, N., Gonzalez-Gay, M.A., Gonzalez-Escribano, M.F., Airo, P., Laar, J. van, Herrick, A., Worthington, J., Hesselstrand, R., Smith, V., Keyser, F. de, Houssiau, F., Chee, M.M., Madhok, R., Shiels, P., Westhovens, R., Kreuter, A., Kiener, H., Baere, E. de, Witte, T.J.M. de, Padykov, L., Klareskog, L., Beretta, L., Scorza, R., Lie, B.A., Hoffmann-Vold, A.M., Carreira, P., Varga, J., Hinchcliff, M., Gregersen, P.K., Lee, A.T., Ying, J., Han, Y., Weng, S.F., Amos, C.I., Wigley, F.M., Hummers, L., Nelson, J.L., Agarwal, S.K., Assassi, S., Gourh, P., Tan, F.K., Koeleman, B.P., Arnett, F.C., Martin, J., and Mayes, M.D.

Subjects
Infection and autoimmunity Auto-immunity, transplantation and immunotherapy [NCMLS 1]
Abstract

Contains fulltext : 97765.pdf (Publisher’s version ) (Closed access) 01 mei 2010

Published
2011

110. Functional variants of Fc gamma receptor (FCGR2A) and FCGR3A are not associated with susceptibility to systemic sclerosis in a large European study (EUSTAR) (Journal of Rheumatology (2010) 37 (1673-1679))

Author

Alizadeh, B.Z., Broen, L., Rueda, B., Hesselstrand, R., Wuttge, D., Simeon, C., Ortego-Centeno, N., Gonzalez-Gay, M.A., Pros, A., Herrick, A., Worthington, J., Denton, C., Fonseca, C., Riemekasten, G., Vonk, M.C., Van Den Hoogen, F., Guiducci, S., Matucci-Cerinic, M., Scorza, R., Beretta, L., Airó, P., Coenen, M., Martin, J., Koeleman, B.P.C., and Radstake, T.R.D.J.

Published
2011

111. mi-siRNAs and Plum pox virus

Author

Ravelonandro, Michel, Scorza, R., Briard, Pascal, Hily, J.M., Génomique, développement et pouvoir pathogène (GD2P), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), United States Department of Agriculture (USDA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], AMIRNA, SIRNA, RNA SILENCING, RNAI, [SDV]Life Sciences [q-bio], VIRUS RESISTANCE, GENETIQUE, ComputingMilieux_MISCELLANEOUS, RESISTANCE, VIROLOGIE
Abstract

International audience

Published
2010

112. Limited pollen movement from transgenic plum (Prunus domestica) demonstrates the potential for GE and conventional plum co-existence

Author

Scorza, R., Callahan, A., Ravelonandro, Michel, USDA-ARS : Agricultural Research Service, Génomique, développement et pouvoir pathogène (GD2P), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], PRUNIER, GENE GIUS, GENETIQUE, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2010

113. Inheritance of RNA silencing and PPV resistance in transgenic progeny of 'Honeysweet' plum

Author

Ravelonandro, Michel, Scorza, R., Briard, Pascal, Lafargue, Bernard, Renaud, Raoul, Génomique, développement et pouvoir pathogène (GD2P), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), United States Department of Agriculture (USDA), Unité de recherches Espèces Fruitières et Vigne (UREFV), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], HONEYSWEET, GENETIQUE, ComputingMilieux_MISCELLANEOUS, RESISTANCE
Abstract

International audience

Published
2010

114. Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus

Author

Radstake, T.R.D.J., Gorlova, O., Rueda, B., Martin, J.E., Alizadeh, B.Z., Palomino-Morales, R., Coenen, M.J., Vonk, M.C., Voskuyl, A.E., Schuerwegh, A.J., Broen, J.C., Riel, P.L.C.M. van, van't Slot, R., Italiaander, A., Ophoff, R.A., Riemekasten, G., Hunzelmann, N., Simeon, C.P., Ortego-Centeno, N., Gonzalez-Gay, M.A., Gonzalez-Escribano, M.F., Airo, P., Laar, J. van, Herrick, A., Worthington, J., Hesselstrand, R., Smith, V., Keyser, F. de, Houssiau, F., Chee, M.M., Madhok, R., Shiels, P., Westhovens, R., Kreuter, A., Kiener, H., Baere, E. de, Witte, T., Padykov, L., Klareskog, L., Beretta, L., Scorza, R., Lie, B.A., Hoffmann-Vold, A.M., Carreira, P., Varga, J., Hinchcliff, M., Gregersen, P.K., Lee, A.T., Ying, J., Han, Y., Weng, S.F., Amos, C.I., Wigley, F.M., Hummers, L., Nelson, J.L., Agarwal, S.K., Assassi, S., Gourh, P., Tan, F.K., Koeleman, B.P.C., Arnett, F.C., Martin, J., Mayes, M.D., and Spanish Scleroderma Grp

Subjects
cd4 t-cells lupus-erythematosus functional polymorphism japanese population cd3-zeta expression complex risk scleroderma mechanisms phenotype
Abstract

Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs that leads to profound disability and premature death. To identify new SSc susceptibility loci, we conducted the first genome-wide association study in a population of European ancestry including a total of 2,296 individuals with SSc and 5,171 controls. Analysis of 279,621 autosomal SNPs followed by replication testing in an independent case-control set of European ancestry (2,753 individuals with SSc (cases) and 4,569 controls) identified a new susceptibility locus for systemic sclerosis at CD247 (1q22-23, rs2056626, P = 2.09 x 10(-7) in the discovery samples, P = 3.39 x 10(-9) in the combined analysis). Additionally, we confirm and firmly establish the role of the MHC (P = 2.31 x 10(-18)), IRF5 (P = 1.86 x 10(-13)) and STAT4 (P = 3.37 x 10(-9)) gene regions as SSc genetic risk factors.

Published
2010

118. Characteristics of joint involvement and relationship with systemic inflammation in systemic sclerosis: result from the EULAR scleroderma trial and research (EUSTAR) database

Author

Avouac, J, Walker, U, Tyndall, A, Kahan, A, Matucci Cerinic, M, Allanore, Y, Eustar, Miniati, I, Muller, A, Iannone, F, Distler, O, Becvar, R, Sierakowsky, S, Kowal Bielecka, O, Coelho, P, Cabane, J, Cutolo, M, Shoenfeld, Y, Valentini, G, Rovensky, J, Riemekasten, G, Vlachoyiannopoulos, P, Caporali, R, Jiri, S, Inanc, M, Zimmermann Gorska, I, Carreira, P, Novak, S, Czirjak, L, Oliveira Ramos, F, Jendro, M, Chizzolini, C, Kucharz, Ej, Richter, J, Cozzi, F, Rozman, B, Mallia, Cm, Gabrielli, A, Farge, D, Kiener, Hp, Schöffel, D, Airo, P, Wollheim, F, Martinovic, D, Trotta, F, Jablonska, S, Reich, K, Bombardieri, S, Siakka, P, Pellerito, R, Bambara, Lm, Morovic Vergles, J, Denton, C, Hinrichs, R, Van den Hoogen, F, Damjanov, N, Kötter, I, Ortiz, V, Heitmann, S, Krasowska, D, Seidel, M, Hasler, P, Van Laar JM, Kaltwasser, Jp, Foeldvari, I, Juan Mas, A, Bajocchi, G, Wislowska, M, Pereira Da Silva JA, Jacobsen, S, Worm, M, Graniger, W, Kuhn, A, Stankovic, A, Cossutta, R, Majdan, M, Damjanovska Rajcevska, L, Tikly, M, Nasonov, El, Steinbrink, K, Herrick, A, Müller Ladner, U, Dinc, A, Scorza, R, Sondergaard, K, Indiveri, F, Nielsen, H, Szekanecz, Z, Silver, Rm, Antivalle, M, Espinosa, Ib, García de la Pena Lefebvre, P, Midtvedt, O, Launay, D, Valesini, F, Tuvik, P, Ionescu, Rm, Del Papa, N, Pinto, S, Wigley, F, Mihai, C, Sinziana Capranu, M, Sunderkötter, C, Jun, Jb, Alhasani, S, Distler, Jh, Ton, E, Soukup, T, Seibold, J, Zeni, S, Nash, P, Mouthon, L, De Keyser, F, Duruöz, Mt, Cantatore, Fp, Strauss, G, von Mülhen CA, Pozzi, Mr, Eyerich, K, Szechinski, J, Keiserman, M, Houssiau, Fa, Román Ivorra JA, Krummel Lorenz, B, Aringer, M, Westhovens, R, Bellisai, F, Mayer, M, Stoeckl, F, Uprus, M, Volpe, A, Buslau, M, Yavuz, S, Granel, B, Valderílio Feijó, A, Del Galdo, F, Popa, S, Zenone, T, Ricardo Machado, X, Pileckyte, M, Stebbings, S, Mathieu, A, Tulli, A, Tourinho, T, Souza, R, Acayaba de Toledo, R, Stamp, L, Solanki, K, Veale, D, Francisco Marques Neto, J, Bagnato, Gf, Loyo, E, Toloza, S, Li, M, Ahmed Abdel Atty Mohamed, W, Cobankara, V, Olas, J, Salsano, F, Oksel, F, Tanaseanu, Cm, Foti, R, Ancuta, C, Vonk, M, Caramaschi, Paola, Beretta, L, Balbir, A, Chiàla, A, Pasalic Simic, K, Ghio, M, Stamenkovic, B, Rednic, S, Host, N, Hachulla, E, and Furst, D. E.

Subjects
joint involvement, Systemic sclerosis, synovitis
Published
2010

119. Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database

Author

Avouac, J., Walker, U., Tyndall, A., Kahan, A., Matucci-Cerinic, M., Allanore, Y., Miniati, I., Müller, A., Iannone, F., Giacomelli, R., Distler, O., Becvar, R., Sierakowsky, S., Kowal-Bielecka, O., Coelho, P., Cabane, J., Cutolo, M., Shoenfeld, Y., Valentini, G., Rovensky, J., Riemekasten, G., Nicoara, I., Vlachoyiannopoulos, P., Caporali, R., Jiri, S., Inanc, M., Gorska, I.Z., Carreira, P., Novak, S., Czirjak, L., Ramos, F.O., Jendro, M., Chizzolini, C., Kucharz, E.J., Richter, J., Cozzi, F., Rozman, B., Mallia, C.M., Gabrielli, A., Farge, D., Kiener, H.P., Schöffel, D., Sticherling, M., Airo, P., Wollheim, F., Martinovic, D., Trotta, F., Hunzelmann, N., Jablonska, S., Reich, K., Bombardieri, S., Siakka, P., Pellerito, R., Bambara, L.M., Morovic-Vergles, J., Denton, C., Hinrichs, R., Van Den Hoogen, F., Damjanov, N., Kötter, I., Ortiz, V., Heitmann, S., Krasowska, D., Seidel, M., Hasler, P., Van Laar, J.M., Kaltwasser, J.P., Foeldvari, I., Juan Mas, A., Bajocchi, G., Wislowska, M., Pereira Da Silva, J.A., Jacobsen, S., Worm, M., Graniger, W., Kuhn, A., Stankovic, A., Cossutta, R., Majdan, M., Rajcevska, L.D., Tikly, M., Nasonov, E.L., Steinbrink, K., Herrick, A., Müller-Ladner, U., Dinc, A., Scorza, R., Sondergaard, K., Indiveri, F., Nielsen, H., Szekanecz, Z., Silver, R.M., Antivalle, M., Espinosa, I.B., García De La Pena Lefebvre, P., Midtvedt, O., Launay, D., Valesini, F., Tuvik, P., Ionescu, R.M., Del Papa, N., Pinto, S., Wigley, F., Mihai, C., Capranu, M.S., Sunderkötter, C., Jun, J.B., Derk, C., Alhasani, S., Distler, J.H., Ton, E., Soukup, T., Seibold, J., Zeni, S., Nash, P., Mouthon, L., De Keyser, F., Duruöz, M.T., Cantatore, F.P., Strauss, G., Von Mülhen, C.A., Pozzi, M.R., Eyerich, K., Szechinski, J., Keiserman, M., Houssiau, F.A., Rom-Ivorra, J.A., Krummel-Lorenz, B., Aringer, M., Westhovens, R., Bellisai, F., Mayer, M., Stoeckl, F., Üprus, M., Volpe, A., Buslau, M., Yavuz, S., Granel, B., Feijó, A.V., Del Galdo, F., Popa, S., Zenone, T., Machado, X.R., Pileckyte, M., Stebbings, S., Mathieu, A., Tulli, A., Tourinho, T., Souza, R., Acayaba De Toledo, R., Stamp, L., Solanki, K., Veale, D., Neto, J.F.M., Bagnato, G.F., Loyo, E., Toloza, S., Li, M., Mohamed, W.A.A.A., Çobankara, Veli, Olas, J., Salsano, F., Oksel, F., Tanaseanu, C.M., Foti, R., Ancuta, C., Vonk, M., Caramashi, P., Beretta, L., Balbir, A., Shine, B., Chiàla, A., Simic, K.P., Ghio, M., Stamenkovic, B., Rednic, S., Host, N., Hachulla, E., and Furst, D.E.

Subjects
musculoskeletal diseases, Adult, Male, Databases, Factual, systemic sclerosis, joint contracture, hand radiography, Joint involvement, Tendons, Scleroderma, Localized, data base, joint radiography, Humans, scleroderma, human, nuclear magnetic resonance imaging, Range of Motion, Articular, rheumatic disease, Aged, interstitial lung disease, Inflammation, skin disease, Clinical Trials as Topic, Synovitis, Scleroderma, Systemic, integumentary system, article, echography, Middle Aged, musculoskeletal system, cohort analysis, major clinical study, tenosynovitis, clinical feature, body regions, female, Cross-Sectional Studies, priority journal, Tendon friction rub, Joints, disease duration, Joint Diseases, disease activity
Abstract

Objective. To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc). Methods. This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs. Results. We recruited 7286 patients with SSc; their mean age was 56 ± 14 years, disease duration 10 ± 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable. Conclusion. Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with amore severe disease and with systemic inflammation. The Journal of Rheumatology Copyright © 2010. All rights reserved.

Published
2010

121. Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis

Author

Bon, L. van, Affandi, A.J., Broen, J.C.A., Christmann, R.B., Marijnissen, R.J., Stawski, L., Farina, G.A., Stifano, G., Mathes, A.L., Cossu, M., York, M., Collins, C., Wenink, M., Huijbens, R., Hesselstrand, R., Saxne, T., DiMarzio, M., Wuttge, D., Agarwal, S.K., Reveille, J.D., Assassi, S., Mayes, M., Deng, Y., Drenth, J.P.H., Graaf, J. de, Heijer, M. den, Kallenberg, C.G.M., Bijl, M. van der, Loof, A., Berg, W.B. van den, Joosten, L.A.B., Smith, V., Keyser, F. de, Scorza, R., Lunardi, C., Riel, P.L.C.M. van, Vonk, M.C., Heerde, W.L. van, Meller, S., Homey, B., Beretta, L., Roest, M., Trojanowska, M., Lafyatis, R., Radstake, T.R.D.J., Bon, L. van, Affandi, A.J., Broen, J.C.A., Christmann, R.B., Marijnissen, R.J., Stawski, L., Farina, G.A., Stifano, G., Mathes, A.L., Cossu, M., York, M., Collins, C., Wenink, M., Huijbens, R., Hesselstrand, R., Saxne, T., DiMarzio, M., Wuttge, D., Agarwal, S.K., Reveille, J.D., Assassi, S., Mayes, M., Deng, Y., Drenth, J.P.H., Graaf, J. de, Heijer, M. den, Kallenberg, C.G.M., Bijl, M. van der, Loof, A., Berg, W.B. van den, Joosten, L.A.B., Smith, V., Keyser, F. de, Scorza, R., Lunardi, C., Riel, P.L.C.M. van, Vonk, M.C., Heerde, W.L. van, Meller, S., Homey, B., Beretta, L., Roest, M., Trojanowska, M., Lafyatis, R., and Radstake, T.R.D.J.

Abstract

Contains fulltext : 136617.pdf (publisher's version ) (Open Access), BACKGROUND: Plasmacytoid dendritic cells have been implicated in the pathogenesis of systemic sclerosis through mechanisms beyond the previously suggested production of type I interferon. METHODS: We isolated plasmacytoid dendritic cells from healthy persons and from patients with systemic sclerosis who had distinct clinical phenotypes. We then performed proteome-wide analysis and validated these observations in five large cohorts of patients with systemic sclerosis. Next, we compared the results with those in patients with systemic lupus erythematosus, ankylosing spondylitis, and hepatic fibrosis. We correlated plasma levels of CXCL4 protein with features of systemic sclerosis and studied the direct effects of CXCL4 in vitro and in vivo. RESULTS: Proteome-wide analysis and validation showed that CXCL4 is the predominant protein secreted by plasmacytoid dendritic cells in systemic sclerosis, both in circulation and in skin. The mean (+/-SD) level of CXCL4 in patients with systemic sclerosis was 25,624+/-2652 pg per milliliter, which was significantly higher than the level in controls (92.5+/-77.9 pg per milliliter) and than the level in patients with systemic lupus erythematosus (1346+/-1011 pg per milliliter), ankylosing spondylitis (1368+/-1162 pg per milliliter), or liver fibrosis (1668+/-1263 pg per milliliter). CXCL4 levels correlated with skin and lung fibrosis and with pulmonary arterial hypertension. Among chemokines, only CXCL4 predicted the risk and progression of systemic sclerosis. In vitro, CXCL4 down-regulated expression of transcription factor FLI1, induced markers of endothelial-cell activation, and potentiated responses of toll-like receptors. In vivo, CXCL4 induced the influx of inflammatory cells and skin transcriptome changes, as in systemic sclerosis. CONCLUSIONS: Levels of CXCL4 were elevated in patients with systemic sclerosis and correlated with the presence and progression of complications, such as lung fibrosis and pulmonary arterial hypert

Published
2014

122. Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis.

Author

Soft Condensed Matter and Biophysics, Sub Soft Condensed Matter, van Bon, L., Affandi, A.J., dr. Broen, J.C.A., Christmann, R.B., Marijnissen, R.J., Stawski, L., Farina, G.A., Stifano, G., Mathes, A.L., Cossu, M., York, M., Collins, C., Wenink, M.H., Huijbens, R., Hesselstrand, R., Saxne, T., Dimarzio, M, Wuttge, D., Agarwal, S.K., Reveille, J.D., Assassi, S., Mayes, M.D., Deng, Y., Drenth, J.P., de Graaf, J., den Heijer, M., Kallenberg, C.G., Bijl, M., de Loof, A., van der Berg, W.B., Joosten, L.A., Smith, V., de Keyser, F., Scorza, R., Lunardi, C., van Riel, P.L.C.M., Vonk, M., van Heerde, W.L., Meller, S., Homey, B., Beretta, L., Roest, M., Trojanowska, M., Lafyatis, R., Radstake, T.R.D.J., Soft Condensed Matter and Biophysics, Sub Soft Condensed Matter, van Bon, L., Affandi, A.J., dr. Broen, J.C.A., Christmann, R.B., Marijnissen, R.J., Stawski, L., Farina, G.A., Stifano, G., Mathes, A.L., Cossu, M., York, M., Collins, C., Wenink, M.H., Huijbens, R., Hesselstrand, R., Saxne, T., Dimarzio, M, Wuttge, D., Agarwal, S.K., Reveille, J.D., Assassi, S., Mayes, M.D., Deng, Y., Drenth, J.P., de Graaf, J., den Heijer, M., Kallenberg, C.G., Bijl, M., de Loof, A., van der Berg, W.B., Joosten, L.A., Smith, V., de Keyser, F., Scorza, R., Lunardi, C., van Riel, P.L.C.M., Vonk, M., van Heerde, W.L., Meller, S., Homey, B., Beretta, L., Roest, M., Trojanowska, M., Lafyatis, R., and Radstake, T.R.D.J.

Published
2014

123. TNFRSF13B Variants in SLE and Immunodeficiency

Author

Chew, Gary, Gatenby, Paul, Mercan, S, De Malmanche, T, Adelstein, Stephen, Garsia, R, Hissaria, Pravin, French, Martyn A., Riminton , D. Sean, Fulcher, David, Scorza, R, D'Alfonso, D, Doria, A, Garcia De Vinuesa, Maria Carola, Cook, Matthew, Chew, Gary, Gatenby, Paul, Mercan, S, De Malmanche, T, Adelstein, Stephen, Garsia, R, Hissaria, Pravin, French, Martyn A., Riminton , D. Sean, Fulcher, David, Scorza, R, D'Alfonso, D, Doria, A, Garcia De Vinuesa, Maria Carola, and Cook, Matthew

Published
2014

124. TNFRSF13B variants in SLE and immunodeficiency

Author

Chew, Gary Y. J, Gatenby, Paul A, Mercan, S, De Malmanche, T, Adelstein, Stephen, Garsia, Roger, Hissaria, Pravin, French, Martyn, Riminton, D. Sean, Fulcher, David A, Scorza, R, D'Alfonso, S, Doria, A, Rua Figueroa, I, Cervera, R, Vasconcelos, C, Martins, B, Alarcon Riquelme, M, Vinuesa, Carola, Cook, Matthew C, Chew, Gary Y. J, Gatenby, Paul A, Mercan, S, De Malmanche, T, Adelstein, Stephen, Garsia, Roger, Hissaria, Pravin, French, Martyn, Riminton, D. Sean, Fulcher, David A, Scorza, R, D'Alfonso, S, Doria, A, Rua Figueroa, I, Cervera, R, Vasconcelos, C, Martins, B, Alarcon Riquelme, M, Vinuesa, Carola, and Cook, Matthew C

Abstract

Background: The co-existence of autoimmunity and primary antibody deficiency in some individiuals is intriguing. The transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) gene (TNFRSF13B) has been implicated in both autoimmunity and primary antibody deficiency to varying extents in mice and humans. However, the phenotype described in mice with TNFRSF13B polymorphisms has not been entirely consistent with patients with similar orthologous polymorphisms. Objective: To further understand the relationship between TNFRSF13B variants and PAD and autoimmunity, we set out to determine the association of the two most common TNFRSF13B polymorphisms with autoimmunity and immunodeficiency, in patients with primary antibody deficiency and SLE. Method: We genotyped the C104R and A181E polymorphisms of TNFRSF13B in193 individuals and 144 controls from the Australian and New Zealand Antibody Deficiency Allele (ANZADA) Study, 107 patients from the Australian Point Mutation in Systemic Lupus Erythematosus (APOSLE) study, 169 patients with SLE from a European population, and 263 European controls. We were also able to determine TNFRSF13B genotypes for family members for nine of twelve pedigrees with primary antibody deficiency identified with TNFRSF13B variants. Results: The total number of TNFRSF13B variants in the primary antibody deficiency cohort was significantly higher than in the control group (p=0.0089; OR 9.481 [95% CI 1.218−73.81]). Similar results were obtained when patients with systemic lupus erythematosus were analysed. TNFRSF13B variants were strongly associated with SLE (p=0.0161, OR 3.316 [95% CI 1.245-8.836]). Familial analysis revealed incomplete penetrance of the TNFRSF13B variants. Conclusion: Taken together, the two most common TNFRSF13B variants are associated with primary antibody deficiency and systemic lupus erythematosus.

Published
2014

125. Hairpin Plum pox virus coat protein (hpPPV-CP) structure in 'HoneySweet' C5 plum provides PPV resistance when genetically engineered into plum (Prunus domestica) seedlings

Author

Scorza, R., Georgi, L., Callahan, A., Petri, C., Hily, J.M., Dardick, C., Damsteegt, V., Ravelonandro, Michel, ARS, Génomique, développement et pouvoir pathogène (GD2P), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], BIOTECHNOLOGIE, [SDV]Life Sciences [q-bio], PRUNIER, HONEYSWEET, GENETIQUE, ComputingMilieux_MISCELLANEOUS, RESISTANCE
Abstract

International audience

Published
2009

126. Silencing in genetically engineered Prunus domestica provides durable and safe resistance to Plum pox virus

Author

Ravelonandro, Michel, Scorza, R., Génomique, développement et pouvoir pathogène (GD2P), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), ARS, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], BIOTECHNOLOGIE, SIRNA, [SDV]Life Sciences [q-bio], PRUNIER, SECURITE ENVIRONNEMENTALE, GENETIQUE, SECURITE BIOLOGIQUE, VIROLOGIE
Abstract

International audience; Originally identified in Bulgaria in 1915, Plum pox virus (PPV) is the most damaging virus of stone fruit trees, including apricot, plum, peach and cherry. PPV steadily spread throughout Europe over the years since its discovery and at the turn of the century (1999-2000) it reached North America (USA and Canada). While many strategies to control the spread of PPV have been undertaken over the decades and many studies have contributed to the characterization of the virus isolates there has been relatively little progress in the development of resistant varieties. With the paucity of natural resistance, transgenic technology, based on the engineering of the virus capsid gene, was investigated as a useful source of resistance. This work identified the C5 plum clone as highly resistant to PPV infection. These findings were supported by detailed molecular studies indicating that post-transcriptional gene silencing (PTGS) is the resistance mechanism with resistance being mediated through the production of small interfering RNA (siRNA). The durability of PPV resistance in C5 (named ‘HoneySweet’) is reflected through more than 10 years of field tests. In total, over 15 years of research with ‘HoneySweet’ have demonstrated that this clone and the resistance mechanism that it represents is: i) an important tool to demonstrate the successful deployment of biotechnology against a quarantine pest; ii) a safe product of biotechnology; and iii) a useful strategy for avoiding the use of pesticides to control natural aphid vectors of PPV. The deregulation of ‘HoneySweet’ in the USA by USDA/APHIS (Federal Register Doc. E7-13649, July 12 2007) and clearance by the U.S. Food and Drug Administration (FDA) corroborate these findings.

Published
2008

127. Behaviour of transgenic plum pox virus-resistant Prunus domestica L. clone C-5 grown in the open field under a high and permanent infection pressure of the PPV-Rec strain

Author

Polak, J., Pivalova, J., Kundu, J.K., Jokes, M., Scorza, R., Ravelonandro, Michel, ProdInra, Migration, Crop research institute, Appalachian Fruit Research Station, USDA-ARS : Agricultural Research Service, Génomique, développement et pouvoir pathogène (GD2P), and Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)

Subjects
BIOTECHNOLOGIE, PRUNIER, PPV-REC, ComputingMilieux_MISCELLANEOUS, [SDV.BV.PEP] Life Sciences [q-bio]/Vegetal Biology/Phytopathology and phytopharmacy, [SDV.BV.PEP]Life Sciences [q-bio]/Vegetal Biology/Phytopathology and phytopharmacy, VIROLOGIE
Abstract

International audience

Published
2008

128. Behaviour of transgenic plum pox virus-resistant Prunus domestica L. clone C-5 grown in the open field under a high and permanent infection pressure of the PPV-Rec strain

Author

Pivalova, J., Kundu, J.K., Jokes, M., Scorza, R., Ravelonandro, Michel, ProdInra, Migration, Crop research institute, Appalachian Fruit Research Station, USDA-ARS : Agricultural Research Service, Génomique, développement et pouvoir pathogène (GD2P), and Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)

Subjects
BIOTECHNOLOGIE, PRUNIER, PPV-REC, ComputingMilieux_MISCELLANEOUS, [SDV.BV.PEP] Life Sciences [q-bio]/Vegetal Biology/Phytopathology and phytopharmacy, [SDV.BV.PEP]Life Sciences [q-bio]/Vegetal Biology/Phytopathology and phytopharmacy, VIROLOGIE
Abstract

International audience

Published
2008

129. Unique digital skin lesions associated with systemic sclerosis

Author

Vespasiani A, Scorza R, Emilio Berti, Giovanni Gasparini, Ruggero Caputo, Angelo V. Marzano, Marzano, A, Berti, E, Gasparini, G, Vespasiani, A, Scorza, R, and Caputo, R

Subjects
Adult, Pathology, medicine.medical_specialty, Systemic disease, Scleroderma, Systemic, Mucinoses, Hand Dermatose, business.industry, Mucinose, Dermatology, Hand Dermatoses, medicine.disease, Connective tissue disease, Scleroderma, Mucinosis, Dissection, Cutaneous focal mucinosis, medicine, Etiology, Humans, Cyst, Female, business, Human
Abstract

A 40-year-old woman with systemic sclerosis presented with multiple, large soft skin lesions with a cystic appearance over the interphalangeal joints of both hands. Aspiration of one of these lesions revealed the presence of a yellowish mucoid material which rapidly reappeared. Surgical dissection and excision of the masses was followed by recurrence a few months later. Pre-operative diagnosis was that of myxoid cysts, but the histological picture was reminiscent of cutaneous focal mucinosis, another form of primary mucinosis. The origin of these unique skin lesions is unclear, but speculation on a possible aetiological relationship between them and systemic sclerosis is presented.

Published
1997

130. Clinical risk assessment of organ manifestations in systemic sclerosis: A report from the EULAR Scleroderma Trials and Research group database

Author

Walker, U.A. Tyndall, A. Czirják, L. Denton, C. Farge-Bancel, D. Kowal-Bielecka, O. Müller-Ladner, U. Bocelli-Tyndall, C. Matucci-Cerinic, M. Riemekasten, G. Brückner, C. Airó, P. Scarsi, M. Scorza, R. Beretta, L. Cozzi, F. Tiso, F. Vonk, M.C. Van Den Hoogen, F.H.J. Wigley, F.M. Hummers, L. Nevskaya, T. Ananieva, L. Miniati, I. Tartaglia, N. Lomater, C. Balbir-Gurman, A. Braun-Moscovici, Y. Bambara, L.M. Caramaschi, P. Valentini, G. Ruocco, L. Krieg, T. Hunzelmann, N. Varjú, C. Carriera, P.E. Joven, B. Iannone, F. Lapadula, G. Kahan, A. Allanore, Y. Gabrielli, A. Imperatore, M. Scheja, A. Wollheim, F. Damjanov, N. Ostojic, P. Saar, P. Tarner, I.H. Kötter, I. Bombardieri, S. Bazzichi, L. Del Papa, N. Comina, D.P. Lo Monaco, A. La Corte, R. Hachulla, E. Launay, D. Distler, O. Ciurea, A. Sierakowski, S. Mitchell, H. Silver, R.M. Krasowska, D. Michalska-Jakubus, M. Tikly, M. Aboo, N. Worm, M. Klaus, P. Rovenský, J. Lukáčová, O. Rozman, B. Sipek, A. Clemente-Coelho, P. Shoenfeld, Y. Langewitch, P. Da Silva José, A.P. Salvador, M.J. Kuhn, A. Erdmann, G. Bečvář, R. Friedl, E. Graninger, W. Riccieri, V. Caporali, R. Montecucco, C. Vlachoyiannopoulos, P. Distler, M. Reich, K. Majdan, M. Wielosz, E. Rednic, S. Van Laar, J.M. Heitmann, S. Bruckner, A. Himsel, A. Riemann, J. Meyringer, R. Müller, A. Martinovic, D. Radic, M. Sticherling, M. Szekanecz, Z. Szücs, G. Giacomelli, R. Marrelli, A. Stamenkovic, B. Stankovic, A. Aringer, M. Smolen, J.S. Kucharz, E.J. Kotulska, A.T. Jablonska, S. Blasczik, M. Jun, J.-B. Mallia, C. Coleiro, B. Santamaria, V.O. Hinrichs, R. Nielsen, H. Cossutta, R. Ionescu, R. Opris, D. Steinbrink, K. Grundt, B. Bajocchi, G. Jiří, Š. Lefebvre, P.G.D.L.P. Zea Mendoza, A.C. Ribi, C. Chizzolini, C. Wisłowska, M. Novak, S. Indiveri, F. Jacobsen, S. Frandsen, P.B. Gorska, I.Z. Tore Gran, J. Midtvedt, Ø. Ramos, F.O. Rajcevska, L.D. Bozinovski, G. Schöffel, D. Sunderkötter, C. Böhm, M. Morović-Vergles, J. Čulo, M.-I. Cutolo, M. Sulli, A. Derk, C.T. Jimenez, S.A. Siakka, P. Søndergaard, K. Stengaard-Pedersen, K. Cabane, J. Tiev, K.P. Mihai, C. Sfrent-Cornateanu, R. Jendro, M. Tuvik, P. Antivalle, M. Randisi, G. Seidel, M. Clarenbach, R. Simsek, I. Dinc, A. Inanc, M. Capraru, M.S. Capraru, D. Bañegil, I. Richter, J. Alhasani, S. Földvari, I. Pinto, S. Brandão, F. Mas, A.J.

Subjects
integumentary system, skin and connective tissue diseases
Abstract

Background: Systemic sclerosis (SSc) is a multisystem autoimmune disease, which is classified into a diffuse cutaneous (dcSSc) and a limited cutaneous (IcSSc) subset according to the skin involvement. In order to better understand the vascular, immunological and fibrotic processes of SSc and to guide its treatment, the EULAR Scleroderma Trials And Research (EUSTAR) group was formed in June 2004. Aims and methods: EUSTAR collects prospectively the Minimal Essential Data Set (MEDS) on all sequential patients fulfilling the American College of Rheumatology diagnostic criteria in participating centres. We aimed to characterise demographic, clinical and laboratory characteristics of disease presentation in SSc and analysed EUSTAR baseline visits. Results: In April 2006, a total of 3656 patients (1349 with dcSSc and 2101 with IcSSc) were enrolled in 102 centres and 30 countries. 1330 individuals had autoantibodies against Scl70 and 1106 against anticentromere antibodies. 87% of patients were women. On multivariate analysis, scleroderma subsets (dcSSc vs IcSSc), antibody status and age at onset of Raynaud's phenomenon, but not gender, were found to be independently associated with the prevalence of organ manifestations. Autoantibody status in this analysis was more closely associated with clinical manifestations than were SSc subsets. Conclusion: dcSSc and IcSSc subsets are associated with particular organ manifestations, but in this analysis the clinical distinction seemed to be superseded by an antibody-based classification in predicting some scleroderma complications. The EUSTAR MEDS database facilitates the analysis of clinical patterns in SSc, and contributes to the standardised assessment and monitoring of SSc internationally.

Published
2007

131. Opposed independent effects and epistasis in the complex association of IRF5 to SLE

Author

Ferreiro-Neira, I. Calaza, M. Alonso-Perez, E. Marchini, M. and Scorza, R. Sebastiani, G. D. Blanco, F. J. Rego, I. and Pullmann, Jr., R. Pullmann, R. Kallenberg, C. G. Bijl, M. and Skopouli, F. N. Mavromati, M. Migliaresi, S. Barizzone, N. Ruzickova, S. Dostal, C. Schmidt, R. E. Witte, T. and Papasteriades, C. Kappou-Rigatou, I. Endreffy, E. Kovacs, A. and Ordi-Ros, J. Balada, E. Carreira, P. Gomez-Reino, J. J. and Gonzalez, A.

Abstract

Genetic variation in the interferon regulatory factor 5 (IRF5) gene affects systemic lupus erythematosus (SLE) susceptibility. However, association is complex and incompletely defined. We obtained fourteen European sample collections with a total of 1383 SLE patients and 1614 controls to better define the role of the different IRF5 variants. Eleven polymorphisms were studied, including nine tag single nucleotide polymorphisms (SNPs) and two extra functional polymorphisms. Two tag SNPs showed independent and opposed associations: susceptibility (rs10488631, P < 10(-17)) and protection (rs729302, P < 10(-6)). Haplotype analyses showed that the susceptibility haplotype, identified by the minor allele of rs10488631, can be due to epistasis between three IRF5 functional polymorphisms. These polymorphisms determine increased mRNA expression, a splice variant with a different exon 1 and a longer proline-rich region in exon 6. This result is striking as none of the three polymorphisms had an independent effect on their own. Protection was independent of these polymorphisms and seemed to reside in the 50 side of the gene. In conclusion, our results help to understand the role of the IRF5 locus in SLE susceptibility by clearly separating protection from susceptibility as caused by independent polymorphisms. In addition, we have found evidence for epistasis between known functional polymorphisms for the susceptibility effect.

Published
2007

132. Bias in association studies of systemic lupus erythematosus susceptibility due to geographical variation in the frequency of a programmed cell death 1 polymorphism across Europe

Author

Ferreiros-Vidal, I. D'Alfonso, S. Papasteriades, C. and Skopouli, F. N. Marchini, M. Scorza, R. Migliaresi, S. and Sebastiani, G. D. Endreffy, E. Mavromati, M. Kappou-Rigatou, I. Ruzickova, S. Dostal, C. Schmidt, R. E. Witte, T. and Gomez-Reino, J. J. Gonzalez, A.

Subjects
immune system diseases, skin and connective tissue diseases
Abstract

We obtained eight collections of DNA samples from ethnically matched systemic lupus erythematosus (SLE) patients and controls from five European countries totaling 783 patients and 1210 controls. A highly significant cline in the frequency of the PD1.3 A allele was found among controls but not among SLE patients. The frequency of the PD1.3 A allele increased from the Northeast to the Southwest of Europe. The cline was clearly apparent (P = 1.2 x 10(-6)) when data from controls of other five SLE susceptibility studies were included in the analysis. This variation has severely biased SLE association studies owing to the lack of parallel changes in SLE patients. As a consequence, the PD1.3 A allele was more common in SLE patients than in controls in the Northeast and Center of Europe, similar to controls in Southeast Europe, and less frequent than in the controls in the Southwest of the Continent. This dissociation in allele frequencies between SLE patients and controls in different subpopulations indicated that programmed cell death 1 variation and disease susceptibility are not independent but the type of relationship is currently unclear. As allele frequency clines are common in other polymorphisms their impact in genetic epidemiology studies should be carefully considered.

Published
2007

134. European Working Party on Systemic Lupus Erythematosus. Systemic lupus erythematosus in Europe at the change of the millennium: lessons from the 'Euro-Lupus Project'

Author

Cervera, R, ABARCA COSTALAGO, M, Abramovicz, D, Allegri, F, Annunziata, P, Aydintug, Ao, Bacarelli, Mr, Bellisai, F, Bernardino, I, BIERNAT KALUZA, E, Blockmans, D, Boki, K, Bracci, L, Campanella, V, Camps, Mt, Carcassi, C, Cattaneo, Roberto, Cauli, A, CHWALINSKA SADOWSKA, H, Contu, L, Cosyns, Jp, Danieli, Mg, Dcruz, D, Depresseux, G, Direskeneli, H, Domènech, I, Espinosa, G, FERNÁNDEZ NEBRO, A, Ferrara, Gb, Font, J, Frutos, Ma, Galeazzi, M, GARCÌA CARRASCO, M, GARCÍA IGLESIAS MF, GARCÍA TOBARUELA, A, George, J, Gil, A, GONZÁLEZ SANTOS, P, Grana, M, Gül, A, Haga, Hj, DE HARO LIGER, M, Houssiau, F, Hughes, Gr, Ingelmo, M, JEDRYKA GÓRAL, A, Khamashta, Ma, Lavilla, P, Levi, Y, LÓPEZ DULPA, M, LÓPEZ SOTO, A, Maldykowa, H, Marcolongo, R, Mathieu, A, Morozzi, G, Nicolopoulou, N, Papasteriades, C, Passiu, G, Perelló, I, Petera, P, Petrovic, R, Piette, Jc, Pintado, V, DE PITA, O, Popovic, R, Pucci, G, Puddu, P, DE RAMÓN, E, RAMOS CASALS, M, RODRÍGUEZ ANDREU, J, RUIZ IRASTORZA, G, SANCHEZ LORA, J, Sanna, G, Scorza, R, Sebastiani, Gd, Sherer, Y, Shoenfeld, Y, Simpatico, A, Sinico, Ra, Smolen, J, Tincani, Angela, Tokgöz, G, URBANO MÁRQUEZ, A, Vasconcelos, C, Vázquez, Jj, Veronesi, J, Vianna, J, and Vivancos, J.

Published
2006

136. The effect of co-infecting viruses on transgenic Plum pox virus resistant plums (Prunus domestica)

Author

Ravelonandro, Michel, Scorza, R., Kundu, J., Briard, Pascal, Monsion, Marie, Génomique, développement et pouvoir pathogène (GD2P), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), United States Department of Agriculture (USDA), and ProdInra, Migration

Subjects
BIOTECHNOLOGIE, ACLSV, RESISTANCE AU VIRUS, [SDV]Life Sciences [q-bio], PLANTE TRANSGENIQUE, PPV, PLUM POX VIRUS, GENETIQUE, CO-INFECTION, [SDV] Life Sciences [q-bio], PNRSV, PRUNIER, VIRUS MULTIPLES, PDV, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2005

137. 'HoneySweet', a transgenic Plum pox virus resistant plum: development, field testing and regulatory issues

Author

Scorza, R., Callahan, A., Hily, J.M., Webb, K., Demuth, M., Cordts, J., Briard, Pascal, Monsion, Marie, Malinowski, T., Zawadzka, B., CAMBRA, Mariano, Capote, N., Zagrai, Ioan, Minoiu, N., Damsteegt, V., Levy, Lilia, Gonsalves, D., Georgi, L., Abbott, Albert, Ravelonandro, Michel, United States Department of Agriculture (USDA), Génomique, développement et pouvoir pathogène (GD2P), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), ISK, Partenaires INRAE, Instituto Valenciano de Investigaciones Agrarias - Institut Valencià d'Investigacions Agraries - Valencian Institute for agricultural Research (IVIA), ASDA-ARS Appalachian Fruit Research Station, United States Department of Agriculture, Clemson University, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], PRUNUS, RESISTANCE AU VIRUS, [SDV]Life Sciences [q-bio], PLANTE TRANSGENIQUE, PPV, PLUM POX VIRUS, BIOLOGIE MOLECULAIRE, GENETIQUE, POTYVIRUS, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2005

138. Molecular interactions between Plum pox virus and the capsid cistron engineered in Prunus domestica

Author

Kundu, J.K., Briard, Pascal, Ravelonandro, Michel, Scorza, R., Research Institute of Crop Production, Génomique, développement et pouvoir pathogène (GD2P), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), United States Department of Agriculture (USDA), and ProdInra, Migration

Subjects
BIOTECHNOLOGIE, [SDV]Life Sciences [q-bio], PLANTE TRANSGENIQUE, PPV, INTERACTION PLANTE VIRUS, PLUM POX VIRUS, BIOLOGIE MOLECULAIRE, POTYVIRUS, [SDV] Life Sciences [q-bio], PCR, INFECTION, PRUNIER, ELISA, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2005

139. Preliminary results of interactions of Plum pox (PPV), Prune dwarf (PDV), and Apple chlorotic leafspot (ACLSV) viruses with transgenic plants of Plum, Prunus domestica L., Stanley, clone C-5 growed in an open field

Author

Pivalova, J., Jokes, M., Svoboda, J., Scorza, R., Ravelonandro, Michel, Crop research institute, United States Department of Agriculture (USDA), Génomique, développement et pouvoir pathogène (GD2P), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
VIRUS DU RABOUGRISSEMENT DU PRUNIER, ACLV, [SDV]Life Sciences [q-bio], PLANTE TRANSGENIQUE, PPV, INTERACTION PLANTE VIRUS, PLUM POX VIRUS, APPLE CHLOROTIC LEAFSPOT VIRUS, BIOLOGIE MOLECULAIRE, GENETIQUE, POTYVIRUS, [SDV] Life Sciences [q-bio], PRUNE DWARF VIRUS, PRUNIER, PDV, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2004

140. Transferring transgene-based sharka resistance through hybridization

Author

Ravelonandro, Michel, Scorza, R., Hily, J.M., Briard, Pascal, Génomique, développement et pouvoir pathogène (GD2P), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), United States Department of Agriculture (USDA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], PRUNUS, [SDV]Life Sciences [q-bio], PPV, PLUM POX VIRUS, BIOLOGIE MOLECULAIRE, GENETIQUE, POTYVIRUS, ComputingMilieux_MISCELLANEOUS, TRANSGENE, RESISTANCE
Abstract

International audience

Published
2004

141. Accumulation of the long class of siRNA is associated with resistance to PPV in a transgenic plum (Prunus domestica)

Author

Hily, J.M., Scorza, R., Ravelonandro, Michel, United States Department of Agriculture (USDA), Génomique, développement et pouvoir pathogène (GD2P), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], SIRNA, [SDV]Life Sciences [q-bio], PRUNIER, PLANTE TRANSGENIQUE, PPV, PLUM POX VIRUS, GENETIQUE, POTYVIRUS, ComputingMilieux_MISCELLANEOUS, SILENCING, RESISTANCE
Abstract

International audience

Published
2004

142. Peach

Author

Abbott, A. G., primary, Arús, P., additional, and Scorza, R., additional

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143. Peaches

Author

Hancock, J.F., primary, Scorza, R., additional, and Lobos, G.A., additional

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145. Investigations of potential impacts in the release of transgenic plums

Author

Ravelonandro, Michel, Minoiu, N., Scorza, R., Génomique, développement et pouvoir pathogène (GD2P), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), Statiunea de Cercetaria, Partenaires INRAE, United States Department of Agriculture (USDA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], PRUNUS, [SDV]Life Sciences [q-bio], PLANTE TRANSGENIQUE, PPV, IMPACT ENVIRONNEMENTAL, PLUM POX VIRUS, RISQUE BIOLOGIQUE, GENETIQUE, POTYVIRUS, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2003

146. Pupillocynetic activity of substance P in systemic sclerosis

Author

DEL ROSSO, A., Bertinotti, L., Pietrini, U., Messori, A., Casale, R., Generini, S., Cozzi, Franco, Czirjak, L, Drosos, Aa, Dziankowska, B, Ferri, C, Gabrielli, A, Giacomelli, R, Hayem, G, Inanc, M, Mchugh, Nj, Nielsen, H, Scorza, R, Tirri, E, VAN DEN HOOGEN FH, and Vlachoyiannopoulos, P. G.

Published
2003

149. Stabilité de la résistance au Plum Pox Virus d'un ligneux

Author

Hily, J.M., Scorza, R., Malinewski, T., Ravelonandro, Michel, ProdInra, Migration, Génomique, développement et pouvoir pathogène (GD2P), and Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], PRUNUS DOMESTICA L, ComputingMilieux_MISCELLANEOUS, RESISTANCE
Abstract

National audience

Published
2003

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