138 results on '"Scoditti, Egeria"'
Search Results
102. Antioxidant and anti-inflammatory properties of tomato fruits synthesizing different amounts of stilbenes
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D’Introno, Annalisa, primary, Paradiso, Annalisa, additional, Scoditti, Egeria, additional, D’Amico, Leone, additional, De Paolis, Angelo, additional, Carluccio, M. Annunziata, additional, Nicoletti, Isabella, additional, DeGara, Laura, additional, Santino, Angelo, additional, and Giovinazzo, Giovanna, additional
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- 2009
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103. Basic mechanisms behind the effects of n-3 fatty acids on cardiovascular disease
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Massaro, Marika, primary, Scoditti, Egeria, additional, Carluccio, Maria Annunziata, additional, and De Caterina, Raffaele, additional
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- 2008
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104. Omega–3 Fatty Acids, Inflammation and Angiogenesis: Nutrigenomic Effects as an Explanation for Anti-Atherogenic and Anti-Inflammatory Effects of Fish and Fish Oils
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Massaro, Marika, primary, Scoditti, Egeria, additional, Carluccio, Maria Annunziata, additional, Montinari, Maria Rosa, additional, and De Caterina, Raffaele, additional
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- 2007
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105. Homocysteine induces VCAM-1 gene expression through NF-κB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants
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Carluccio, Maria Annunziata, primary, Ancora, Maria Assunta, additional, Massaro, Marika, additional, Carluccio, Marisa, additional, Scoditti, Egeria, additional, Distante, Alessandro, additional, Storelli, Carlo, additional, and De Caterina, Raffaele, additional
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- 2007
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106. Abstract 4171: Olive Oil Phenolic Antioxidants Reduce Metalloproteinase (MMP)-9 Expression and Release in Human Monocytoid Cells: Possible Contribution to Plaque Stability
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Carluccio, Maria Annunziata, primary, Massaro, Marika, additional, Scoditti, Egeria, additional, Storelli, Carlo, additional, Distante, Alessandro, additional, Visioli, Francesco, additional, and De Caterina, Raffaele, additional
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- 2006
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107. Olive Oil and Red Wine Antioxidant Polyphenols Inhibit Endothelial Activation
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Carluccio, Maria Annunziata, primary, Siculella, Luisa, additional, Ancora, Maria Assunta, additional, Massaro, Marika, additional, Scoditti, Egeria, additional, Storelli, Carlo, additional, Visioli, Francesco, additional, Distante, Alessandro, additional, and De Caterina, Raffaele, additional
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- 2003
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108. Antioxidant and anti-inflammatory properties of tomato fruits synthesizing different amounts of stilbenes.
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D'Introno, Annalisa, Paradiso, Annalisa, Scoditti, Egeria, D'Amico, Leone, De Paolis, Angelo, Carluccio, M. Annunziata, Nicoletti, Isabella, DeGara, Laura, Santino, Angelo, and Giovinazzo, Giovanna
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TOMATOES ,RESVERATROL ,STILBENE ,PHENOLS ,BIOSYNTHESIS ,TRANSGENIC plants ,ANTIOXIDANTS ,PHORBOL esters ,MONOCYTES ,MACROPHAGES ,OXYGENASES ,PHYSIOLOGY - Abstract
Resveratrol, a plant phenolic compound, is found in grapes and red wine, but is not widely distributed in other common food sources. The pathway for resveratrol biosynthesis is well characterized. Metabolic engineering of this compound has been achieved in tomato plants ( Lycopersicon esculentum Mill.) in order to improve their nutritional value. Tomato plants synthesizing resveratrol were obtained via the heterologous expression of a grape ( Vitis vinifera L.) cDNA encoding for the enzyme stilbene synthase (StSy), under the control of the fruit-specific promoter TomLoxB. The resulting LoxS transgenic plants accumulated trans-resveratrol and trans-piceid, in particular in the skin of the mature fruits. Quantitative analyses carried out on LoxS fruits were compared with those of a tomato line constitutively expressing the stsy gene (35SS). The LoxS fruits contained levels of trans-resveratrol that were 20-fold lower than those previously reported for the 35SS line. The total antioxidant capability and ascorbate content in transformed fruits were also evaluated, and a significant increase in both was found in the LoxS and 35SS lines. These results could explain the higher capability of transgenic fruits to counteract the pro-inflammatory effects of phorbol ester in monocyte–macrophages via the inhibition of induced cyclo-oxygenase-2 enzyme. [ABSTRACT FROM AUTHOR]
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- 2009
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109. Omega-3 Fatty Acids, Inflammation and Angiogenesis: Nutrigenomic Effects as an Explanation for Anti-Atherogenic and Anti-Inflammatory Effects of Fish and Fish Oils.
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Massaro, Marika, Scoditti, Egeria, Carluccio, Maria Annunziata, Montinari, Maria Rosa, and De Caterina, Raffaele
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- 2007
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110. Dipyridamole decreases inflammatory metalloproteinase-9 expression and release by human monocytes
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Massaro, Marika, Scoditti, Egeria, Carluccio, Maria Annunziata, Pellegrino, Mariangela, Calabriso, Nadia, Storelli, Carlo, Martines, Giuseppe, and De Caterina, Raffaele
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- 2013
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111. Coenzyme Q 10 : Clinical Applications beyond Cardiovascular Diseases.
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Testai, Lara, Martelli, Alma, Flori, Lorenzo, Cicero, Arrigo F. G., Colletti, Alessandro, and Scoditti, Egeria
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Coenzyme Q
10 (CoQ10 ) is an essential cofactor in oxidative phosphorylation (OXPHOS), present in mitochondria and cell membranes in reduced and oxidized forms. Acting as an energy transfer molecule, it occurs in particularly high levels in the liver, heart, and kidneys. CoQ10 is also an anti-inflammatory and antioxidant agent able to prevent the damage induced by free radicals and the activation of inflammatory signaling pathways. In this context, several studies have shown the possible inverse correlation between the blood levels of CoQ10 and some disease conditions. Interestingly, beyond cardiovascular diseases, CoQ10 is involved also in neuronal and muscular degenerative diseases, in migraine and in cancer; therefore, the supplementation with CoQ10 could represent a viable option to prevent these and in some cases might be used as an adjuvant to conventional treatments. This review is aimed to summarize the clinical applications regarding the use of CoQ10 in migraine, neurodegenerative diseases (including Parkinson and Alzheimer diseases), cancer, or degenerative muscle disorders (such as multiple sclerosis and chronic fatigue syndrome), analyzing its effect on patients' health and quality of life. [ABSTRACT FROM AUTHOR]- Published
- 2021
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112. Nutraceuticals and Prevention of Atherosclerosis: Focus on ?-3 Polyunsaturated Fatty Acids and Mediterranean Diet Polyphenols
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Massaro, Marika, Scoditti, Egeria, Carluccio, Maria Annunziata, and De Caterina, Raffaele
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Nutraceuticals are potentially healthful foods that play a role in maintaining human well being, enhancing health and preventing, or even treating, specific diseases. More than for any other diseases, cardiovascular diseases occur in association with risk factors that are amenable to prevention or treatment by nutraceutical interventions. Several ingredients marketed for use in dietary supplements address such risk factors. The ability of nutraceuticals to favorably influence cardiovascular risk factors and atherosclerotic vascular disease should be recognized as an enormous opportunity for the prevention or treatment of this common condition. In this review, we attempt at summarizing some of the recent research findings on ?-3-polyunsaturated fatty acids and antioxidant polyphenols that have beneficial cardiovascular effects to update the practicing clinicians on the potential benefits of nutraceuticals in this area.
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- 2010
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113. Beneficial Actions of Orostachys japonica and Its Compounds against Tumors via MAPK Signaling Pathways.
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Hur, Soyoung, Jang, Eungyeong, Lee, Jang-Hoon, and Scoditti, Egeria
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Tumors are one of the most life-threatening diseases, and a variety of cancer treatment options have been continuously introduced in order to overcome cancer and improve conventional therapy. Orostachys japonica (O. japonica), which is a perennial plant belonging to the genus Orostachys of the Crassulaceae family, has been revealed to exhibit pharmacological properties against various tumors in numerous studies. The present review aimed to discuss the biological actions and underlying molecular mechanisms of O. japonica and its representative compounds—kaempferol and quercetin—against tumors. O. japonica reportedly has antiproliferative, anti-angiogenic, and antimetastatic activities against various types of malignant tumors through the induction of apoptosis and cell cycle arrest, a blockade of downstream vascular endothelial growth factor (VEGF)-VEGFR2 pathways, and the regulation of epithelial-to-mesenchymal transition. In addition, emerging studies have highlighted the antitumor efficacy of kaempferol and quercetin. Interestingly, it was found that alterations of the mitogen-activated protein kinase (MAPK) signaling cascades are involved in the pivotal mechanisms of the antitumor effects of O. japonica and its two compounds against cancer cell overgrowth, angiogenesis, and metastasis. In summary, O. japonica could be considered a preventive and therapeutic medicinal plant which exhibits antitumor actions by reversing altered patterns of MAPK cascades, and kaempferol and quercetin might be potential components that can contribute to the efficacy and underlying mechanism of O. japonica. [ABSTRACT FROM AUTHOR]
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- 2021
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114. Omega‐3 polyunsaturated fatty acids and pulmonary arterial hypertension: Insights and perspectives.
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Massaro, Marika, Quarta, Stefano, Calabriso, Nadia, Carluccio, Maria Annunziata, Scoditti, Egeria, Mancuso, Peter, De Caterina, Raffaele, and Madonna, Rosalinda
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UNSATURATED fatty acids , *PULMONARY arterial hypertension , *OMEGA-3 fatty acids , *LIFE expectancy , *MEDICAL research , *PULMONARY hypertension - Abstract
Pulmonary arterial hypertension (PAH) is a rare and progressive disorder that affects the pulmonary vasculature. Although recent developments in pharmacotherapy have extended the life expectancy of PAH patients, their 5‐year survival remains unacceptably low, underscoring the need for multitarget and more comprehensive approaches to managing the disease. This should incorporate not only medical, but also lifestyle interventions, including dietary changes and the use of nutraceutical support. Among these strategies, n‐3 polyunsaturated fatty acids (n‐3 PUFAs) are emerging as promising agents able to counteract the inflammatory component of PAH. In this narrative review, we aim at analysing the preclinical evidence for the impact of n‐3 PUFAs on the pathogenesis and the course of PAH. Although evidence for the role of n‐3 PUFAs deficiencies in the development and progression of PAH in humans is limited, preclinical studies suggest that these dietary components may influence several aspects of the pathobiology of PAH. Further clinical research should test the efficacy of n‐3 PUFAs on top of approved clinical management. These studies will provide evidence on whether n‐3 PUFAs can genuinely serve as a valuable tool to enhance the efficacy of pharmacotherapy in the treatment of PAH. [ABSTRACT FROM AUTHOR]
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- 2024
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115. Effect of Cocoa Products and Its Polyphenolic Constituents on Exercise Performance and Exercise-Induced Muscle Damage and Inflammation: A Review of Clinical Trials.
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Marika, Massaro, Scoditti, Egeria, Carluccio, Maria Annunziata, Kaltsatou, Antonia, and Cicchella, Antonio
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In recent years, the consumption of chocolate and, in particular, dark chocolate has been "rehabilitated" due to its high content of cocoa antioxidant polyphenols. Although it is recognized that regular exercise improves energy metabolism and muscle performance, excessive or unaccustomed exercise may induce cell damage and impair muscle function by triggering oxidative stress and tissue inflammation. The aim of this review was to revise the available data from literature on the effects of cocoa polyphenols on exercise-associated tissue damage and impairment of exercise performance. To this aim, PubMed and Web of Science databases were searched with the following keywords: "intervention studies", "cocoa polyphenols", "exercise training", "inflammation", "oxidative stress", and "exercise performance". We selected thirteen randomized clinical trials on cocoa ingestion that involved a total of 200 well-trained athletes. The retrieved data indicate that acute, sub-chronic, and chronic cocoa polyphenol intake may reduce exercise-induced oxidative stress but not inflammation, while mixed results are observed in terms of exercise performance and recovery. The interpretation of available results on the anti-oxidative and anti-inflammatory activities of cocoa polyphenols remains questionable, likely due to the variety of physiological networks involved. Further experimental studies are mandatory to clarify the role of cocoa polyphenol supplementation in exercise-mediated inflammation. [ABSTRACT FROM AUTHOR]
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- 2019
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116. Olive oil phenolic antioxidants reduce metalloproteinase (MMP)-9 expression and release in human monocytoid cells: Possible contribution to plaque stability
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Carluccio, Maria Annunziata, Marika Massaro, Scoditti, Egeria, Storelli, Carlo, Distante, Alessandro, Visioli, Francesco, and Caterina, Raffaele
117. Microarray Analysis of Human Umbilical Vein Endothelial Cells (HUVEC) Treated with the omega-3 Fatty Acid Docosahexaenoic Acid (DHA) Highlights New Anti-Atherosclerotic and Anti-Angiogenic Properties for Fish and Fish Oil
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Scoditti, Egeria, Marika Massaro, Carluccio, Maria Annunziata, Martinelli, Rosanna, Buonomo, Tonia, Martines, Giuseppe, Storelli, Carlo, and Caterina, Raffaele
118. Anti-inflammatory Effects of omega-3 polyunsaturated Fatty Acid and Hydroxytyrosol in Murine 3T3-L1 Adipocytes - A Protective Mechanism of Mediterranean Diets in Obesity
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Scoditti, Egeria, Marika Massaro, Carluccio, Maria Annunziata, Gastaldelli, Amalia, Storelli, Carlo, and Caterina, Raffaele
119. Assessment of Subjective Well-Being in a Cohort of University Students and Staff Members: Association with Physical Activity and Outdoor Leisure Time during the COVID-19 Pandemic
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Stefano Quarta, Annalisa Levante, María-Teresa García-Conesa, Flavia Lecciso, Egeria Scoditti, Maria Annunziata Carluccio, Nadia Calabriso, Fabrizio Damiano, Giuseppe Santarpino, Tiziano Verri, Paula Pinto, Luisa Siculella, Marika Massaro, Quarta, Stefano, Levante, Annalisa, Garcia-Conesa, Maria Teresa, Lecciso, Flavia, Scoditti, Egeria, Carluccio, Maria Annunziata, Calabriso, Nadia, Damiano, Fabrizio, Santarpino, Giuseppe, Verri, Tiziana, Pinto, Paula, Siculella, Luisa, Massaro, Marika, Fundação para a Ciência e a Tecnologia (Portugal), Ministério da Educação e Ciência (Portugal), Quarta, Stefano [0000-0003-1589-4177], Levante, Annalisa [0000-0002-3250-3839], García Conesa, María-Teresa [0000-0002-4125-853X], Scoditti, Egeria [0000-0003-2753-8487], Carluccio, Maria Annunziata [0000-0002-8307-1829], Calabriso, Nadia [0000-0003-0726-2081], Damiano, Fabrizio [0000-0001-7828-9519], Verri, Tiziano [0000-0003-4983-2767], Pinto, Paula [0000-0001-6379-1768], Siculella, Luisa [0000-0002-6890-3674], García Conesa, María-Teresa, and Verri, Tiziano
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Quality of life ,sport practice ,Universities ,Health, Toxicology and Mutagenesis ,social relationship ,Anxiety ,General health ,Leisure Activities ,Humans ,distre ,Students ,Exercise ,Pandemics ,Social relationship ,Cross-Sectional Studie ,Pandemic ,Depression ,SARS-CoV-2 ,Distress ,Public Health, Environmental and Occupational Health ,Time spent in nature ,COVID-19 ,Sport practice ,Universitie ,general health ,Cross-Sectional Studies ,quality of life ,subjective well-being (SWB) ,Subjective well-being (SWB) ,Leisure Activitie ,Communicable Disease Control ,Mental health ,distress ,mental health ,time spent in nature ,Student ,Human - Abstract
Time spent outdoors and physical activity (PA) promote mental health. To confirm this relationship in the aftermath of COVID-19 lockdowns, we explored individual levels of anxiety, depression, stress and subjective well-being (SWB) in a cohort of academic students and staff members and tested their association with sport practice, PA at leisure time and time spent outdoors. Our cross-sectional study collected data during the COVID-19 outbreak (April–May 2021) on 939 students and on 238 employees, who completed an online survey on sociodemographic and lifestyle features, depression, anxiety, stress, and SWB. Results showed that the students exhibited higher levels of anxiety, depression, and stress, and lower levels of SWB (p < 0.001 for all domains) compared to the staff members. Correlation analysis confirmed that PA and time spent in nature were associated to high mental health scores among staff and, more consistently, among students. Finally, mediation analyses indicated that the time spent in nature, social relationships, and levels of energy play a mediator role in the relationship between sport practice and SWB. Our evidence reinforces the protective role of time spent in nature in improving mental health, and provides support for policymakers to make appropriate choices for a better management of COVID-19 pandemic consequences, P.P. was funded by Life Quality Research Centre—UIDP/04748/2020, a program financially supported by FCT—Fundação para a Ciência e Tecnolo-gia/Ministério da Educação e Ciência.
- Published
- 2022
120. Role of sleep deprivation in immune-related disease risk and outcomes.
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Garbarino, Sergio, Lanteri, Paola, Bragazzi, Nicola Luigi, Magnavita, Nicola, and Scoditti, Egeria
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SLEEP deprivation , *INFLAMMATION , *PATHOLOGICAL physiology , *NEURODEGENERATION , *MODERN society , *SLEEP - Abstract
Modern societies are experiencing an increasing trend of reduced sleep duration, with nocturnal sleeping time below the recommended ranges for health. Epidemiological and laboratory studies have demonstrated detrimental effects of sleep deprivation on health. Sleep exerts an immune-supportive function, promoting host defense against infection and inflammatory insults. Sleep deprivation has been associated with alterations of innate and adaptive immune parameters, leading to a chronic inflammatory state and an increased risk for infectious/inflammatory pathologies, including cardiometabolic, neoplastic, autoimmune and neurodegenerative diseases. Here, we review recent advancements on the immune responses to sleep deprivation as evidenced by experimental and epidemiological studies, the pathophysiology, and the role for the sleep deprivation-induced immune changes in increasing the risk for chronic diseases. Gaps in knowledge and methodological pitfalls still remain. Further understanding of the causal relationship between sleep deprivation and immune deregulation would help to identify individuals at risk for disease and to prevent adverse health outcomes. Garbarino et al review recent experimental and epidemiological developments regarding immune responses to sleep deprivation and consider the role for the sleep deprivation induced immune changes in increasing the risk for chronic diseases. [ABSTRACT FROM AUTHOR]
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- 2021
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121. Improving the reporting quality of intervention trials addressing the inter-individual variability in response to the consumption of plant bioactives: quality index and recommendations.
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Nikolic, Marina, Konic Ristic, Aleksandra, González-Sarrías, Antonio, Istas, Geoffrey, Urpi-Sarda, Mireia, Dall'Asta, Margherita, Monfoulet, Laurent-Emmanuel, Cloetens, Lieselotte, Bayram, Banu, Tumolo, Maria Rosaria, Chervenkov, Mihail, Scoditti, Egeria, Massaro, Marika, Tejera, Noemi, Abadjieva, Desislava, Chambers, Karen, Krga, Irena, Tomás-Barberán, Francisco A., Morand, Christine, and Feliciano, Rodrigo
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CLINICAL trials , *DIETARY supplements , *GENETIC polymorphisms , *EDIBLE plants , *QUALITY assurance , *STATISTICS , *SURVEYS , *PHYTOCHEMICALS , *TREATMENT effectiveness ,RESEARCH evaluation - Abstract
Purpose: The quality of the study design and data reporting in human trials dealing with the inter-individual variability in response to the consumption of plant bioactives is, in general, low. There is a lack of recommendations supporting the scientific community on this topic. This study aimed at developing a quality index to assist the assessment of the reporting quality of intervention trials addressing the inter-individual variability in response to plant bioactive consumption. Recommendations for better designing and reporting studies were discussed. Methods: The selection of the parameters used for the development of the quality index was carried out in agreement with the scientific community through a survey. Parameters were defined, grouped into categories, and scored for different quality levels. The applicability of the scoring system was tested in terms of consistency and effort, and its validity was assessed by comparison with a simultaneous evaluation by experts' criteria. Results: The "POSITIVe quality index" included 11 reporting criteria grouped into four categories (Statistics, Reporting, Data presentation, and Individual data availability). It was supported by detailed definitions and guidance for their scoring. The quality index score was tested, and the index demonstrated to be valid, reliable, and responsive. Conclusions: The evaluation of the reporting quality of studies addressing inter-individual variability in response to plant bioactives highlighted the aspects requiring major improvements. Specific tools and recommendations favoring a complete and transparent reporting on inter-individual variability have been provided to support the scientific community on this field. Key messages: The reporting quality of human studies on inter-individual variation in response to plant bioactives is generally low and should be significantly improved. There is no specific guidance for reporting studies on inter-individual variation in response to plant bioactives. The assessment of reporting quality using a scale approach is considered a valuable tool in assessing compliance with the recommendations in the submission phase or during the reviewing process. It also provides a quantitative measure of the quality of studies to be used in meta-analysis. Eleven reporting criteria were developed and supported by detailed definitions and guidance for their scoring. The POSITIVe quality index was tested and demonstrated to be valid, reliable, and responsive. The use of the quality index and its supporting explanatory material (dictionary) as a guide for researchers, peer-reviewers, and journal editors will foster further complete and transparent reporting of data on inter-individual variability. The criteria used in the quality index can serve as additional guidance to inform the design and conduction of further studies on inter-individual variations in response to plant bioactives. Better reporting is expected to lead to a better understanding of the mechanisms and factors involved and thus better study designs with greater impact on policies and practice. [ABSTRACT FROM AUTHOR]
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- 2019
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122. Analysis of the Anti-Inflammatory and Anti-Osteoarthritic Potential of Flonat Fast®, a Combination of Harpagophytum Procumbens DC. ex Meisn., Boswellia Serrata Roxb., Curcuma longa L., Bromelain and Escin (Aesculus hippocastanum), Evaluated in In Vitro Models of Inflammation Relevant to Osteoarthritis
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Stefano Quarta, Giuseppe Santarpino, Maria Annunziata Carluccio, Nadia Calabriso, Egeria Scoditti, Luisa Siculella, Fabrizio Damiano, Michele Maffia, Tiziano Verri, Raffaele De Caterina, Marika Massaro, Quarta, Stefano, Santarpino, Giuseppe, Annunziata Carluccio, Maria, Calabriso, Nadia, Scoditti, Egeria, Siculella, Luisa, Damiano, Fabrizio, Maffia, Michele, Verri, Tiziano, De Caterina, Raffaele, and Massaro, Marika
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antioxidant ,inflammation ,angiogenesis ,monocyte recruitment ,osteoarthritis ,plant bioactives ,antioxidants ,nutritional supplements ,immune response ,Drug Discovery ,nutritional supplement ,Pharmaceutical Science ,Molecular Medicine ,angiogenesi ,osteoarthriti - Abstract
Osteoarthritis (OA) is a joint disease characterized by inflammation of the synovium, angiogenesis, cartilage degradation, and osteophyte formation. Harpagophytum Procumbens DC. ex Meisn., Boswellia Serrata Roxb., Curcuma longa L., Bromelain and Escin (Aesculus hippocastanum) are plants which extracts, together to Bromelain and Escin (Aesculus hippocastanum) are traditionally used in OA. However, their mechanistic role remains unclear. We aimed to investigate whether these bioactives alone or in combination (as in Flonat Fast®) can suppress TNF-α-induced inflammation, angiogenesis, and osteophyte formation using two cell models involved in OA: endothelial cells and monocytes. Each plant extract was evaluated for its polyphenol content, antioxidant activity, and toxicity. In endothelial cells and monocytes, expression of genes involved in OA was assessed, functional assays for inflammation and angiogenesis were performed, and impairment of reactive oxygen species production (ROS) was evaluated. Exposure of cells to the bioactives alone and in combination before cytokine stimulation resulted in differential counterregulation of several gene and protein expressions, including those for cyclooxygenases-2, metalloproteinase-9, transforming growth factor β1, and bone morphogenic protein-2. We demonstrated that these bioactives modulated monocyte adhesion to endothelial cells as well as cell migration and endothelial angiogenesis. Consistent with radical scavenging activity in the cell-free system, the bioactives curbed TNF-α-stimulated intracellular ROS production. We confirmed the potential anti-inflammatory and antiangiogenic effects of the combination of Harpagophytum procumbens, Boswellia, Curcuma, Bromelain, and Escin and provided new mechanistic evidence for their use in OA. However, further clinical studies are needed to evaluate the true clinical utility of these bioactives as supportive, preventive, and therapeutic agents.
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- 2022
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123. Coffee Bioactive N-Methylpyridinium Attenuates Tumor Necrosis Factor (TNF)-α-Mediated Insulin Resistance and Inflammation in Human Adipocytes
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Maria Annunziata Carluccio, Marika Massaro, Nadia Calabriso, Tiziano Verri, Stefano Quarta, Fabrizio Damiano, Luisa Siculella, Egeria Scoditti, Raffaele De Caterina, Pedro Mena, Claudia Favari, Martin Wabitsch, Giuseppe Santarpino, Daniele Del Rio, Quarta, Stefano, Scoditti, Egeria, Carluccio Maria, Annunziata, Calabriso, Nadia, Santarpino, Giuseppe, Damiano, Fabrizio, Siculella, Luisa, Wabitsch, Martin, Verri, Tiziano, Favari, Claudia, Del Rio, Daniele, Mena, Pedro, De Caterina, Raffaele, and Massaro, Marika.
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medicine.medical_specialty ,Chemokine ,adipocytes ,Peroxisome proliferator-activated receptor ,Pyridinium Compounds ,coffee bioactives ,Coffee ,Microbiology ,Biochemistry ,Article ,Mice ,chemistry.chemical_compound ,Downregulation and upregulation ,Trigonelline ,3T3-L1 Cells ,Adipocyte ,Internal medicine ,insulin resistance ,Diabetes Mellitus ,medicine ,Animals ,Humans ,Insulin ,Obesity ,Molecular Biology ,Metabolic Syndrome ,chemistry.chemical_classification ,Adipogenesis ,biology ,Adiponectin ,Tumor Necrosis Factor-alpha ,Intercellular adhesion molecule ,QR1-502 ,N-methylpyridinium ,Glucose ,Endocrinology ,coffee bioactives, N-methylpyridinium, adipocytes, inflammation, insulin resistance ,chemistry ,inflammation ,biology.protein ,Tumor necrosis factor alpha - Abstract
Although coffee consumption has been historically associated with negative health outcomes, recent evidence suggests a lower risk of metabolic syndrome, obesity and diabetes among regular coffee drinkers. Among the plethora of minor organic compounds assessed as potential mediators of coffee health benefits, trigonelline and its pyrolysis product N-methylpyridinium (NMP) were preliminary shown to promote glucose uptake and exert anti-adipogenic properties. Against this background, we aimed at characterizing the effects of trigonelline and NMP in inflamed and dysfunctional human adipocytes. Human Simpson-Golabi-Behmel syndrome (SGBS) adipocytes were treated with NMP or, for comparison, trigonelline, for 5 h before stimulation with tumor necrosis factor (TNF)-α. NMP at concentrations as low as 1 µmol/L reduced the stimulated expression of several pro-inflammatory mediators, including C-C Motif chemokine ligand (CCL)-2, C-X-C Motif chemokine ligand (CXCL)-10, and intercellular adhesion Molecule (ICAM)-1, but left the induction of prostaglandin G/H synthase (PTGS)2, interleukin (IL)-1β, and colony stimulating factor (CSF)1 unaffected. Furthermore, NMP restored the downregulated expression of adiponectin (ADIPOQ). These effects were functionally associated with downregulation of the adhesion of monocytes to inflamed adipocytes. Under the same conditions, NMP also reversed the TNF-α-mediated suppression of insulin-stimulated Ser473 Akt phosphorylation and attenuated the induction of TNF-α-stimulated lipolysis restoring cell fat content. In an attempt to preliminarily explore the underlying mechanisms of its action, we show that NMP restores the expression of the master regulator of adipocyte differentiation peroxisome proliferator-activated receptor (PPAR)γ and downregulates activation of the pro-inflammatory mitogen-activated protein jun N-terminal kinase (JNK). In conclusion, NMP reduces adipose dysfunction in pro-inflammatory activated adipocytes. These data suggest that bioactive NMP in coffee may improve the inflammatory and dysmetabolic milieu associated with obesity.
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- 2021
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124. Olfactory Assessment and new technologies : a neuro-developmental approach with implication for metabolic health
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Sara Invitto, Domenico Toraldo, Giorgio Trianni, Pasquale Paladini, Egeria Scoditti, AIP_ SEPEX, Invitto, Sara, Toraldo, Domenico, Trianni, Giorgio, Paladini, Pasquale, and Scoditti, Egeria
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Olfactory cognition, OERP - Abstract
The olfactory system is extremely connected to the gustatory system, and at an evolutionary level, the appetite stimulation is elicited by drivers connected to cross-modal and multisensory trigger. The most recent technological tools now allow both to reconstruct in the laboratory sophisticated odors, and to administer the same smells through olfactometers interfaced with neuroimaging instruments. The purpose of this presentation will be to illustrate, through a neurodevelopmental approach, several studies carried out to evaluate both Olfactory Event Related Potentials and gamma variation to olfactory responses, presenting odorous stimuli with edible and non-edible characteristics and associating these parameters with metabolic (i.e, Body Mass Index and neuroendocrine regulators) and dietary characteristics of the subjects, to evaluate how the olfactory guided behaviour can exist. Data will be presented regarding studies conducted with a new patented olfactory device, the US2017127971 (A1), on Obstructive Sleep Apnea Subjects, Mild Cognitive Impairment, healthy adults and newborns and newborns the 3 M syndrome (a rare disease).
- Published
- 2018
125. Hepatic glucose metabolism in the steatotic liver.
- Author
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Scoditti E, Sabatini S, Carli F, and Gastaldelli A
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- Humans, Glucose metabolism, Liver metabolism, Fatty Liver metabolism
- Abstract
The liver is central in regulating glucose homeostasis, being the major contributor to endogenous glucose production and the greatest reserve of glucose as glycogen. It is both a target and regulator of the action of glucoregulatory hormones. Hepatic metabolic functions are altered in and contribute to the highly prevalent steatotic liver disease (SLD), including metabolic dysfunction-associated SLD (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). In this Review, we describe the dysregulation of hepatic glucose metabolism in MASLD and MASH and associated metabolic comorbidities, and how advances in techniques and models for the assessment of hepatic glucose fluxes in vivo have led to the identification of the mechanisms related to the alterations in glucose metabolism in MASLD and comorbidities. These fluxes can ultimately increase hepatic glucose production concomitantly with fat accumulation and alterations in the secretion and action of glucoregulatory hormones. No pharmacological treatment has yet been approved for MASLD or MASH, but some antihyperglycaemic drugs approved for treating type 2 diabetes have shown positive effects on hepatic glucose metabolism and hepatosteatosis. A deep understanding of how MASLD affects glucose metabolic fluxes and glucoregulatory hormones might assist in the early identification of at-risk individuals and the use or development of targeted therapies., (© 2024. Springer Nature Limited.)
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- 2024
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126. Effects of working from home on lifestyle behaviors and mental health during the COVID-19 pandemic: A survey study.
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Scoditti E, Bodini A, Sabina S, Leo CG, Mincarone P, Rissotto A, Fusco S, Guarino R, Ponzini G, Tumolo MR, Magnavita N, Tripepi GL, and Garbarino S
- Subjects
- Humans, Pandemics prevention & control, Mental Health, Cross-Sectional Studies, Life Style, Body Weight, Surveys and Questionnaires, COVID-19 epidemiology, COVID-19 prevention & control
- Abstract
The COVID-19 outbreak has led to relevant changes in everyday life worldwide. One of these changes has been a rapid transition to and an increasing implementation of working from home (WH) modality. This study aimed to evaluate the impact of mandatory WH during the COVID-19 pandemic on lifestyle behaviors, Mediterranean diet adherence, body weight, and depression. An online cross-sectional survey was conducted in the early 2022 at the National Research Council of Italy using ad hoc questions and validated scales collecting information on physical activity, sedentary behavior, hobbies/pastimes, dietary habits including adherence to the Mediterranean diet, body weight, and depression during WH compared with before WH. 748 respondents were included in the study. An increased sedentary lifetime was reported by 48% of respondents; however, the subsample of workers who previously performed moderate physical activity intensified this activity. Body weight gain during WH was self-reported in 39.9% of respondents. Mediterranean diet adherence increased (p≪0.001) during WH compared with before WH. The average level of mental health did not record an overall variation; however, the proportion of subjects with mild and moderate depression increased (p = 0.006), while workers who reported values indicative of depression before the transition declared an improvement. These findings highlight health-related impact of WH during the COVID-19 pandemic that may inform future strategies and policies to improve employees' health and well-being., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Scoditti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2024
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127. Circadian Oscillations of Minimal Erythema Dose (MED) are Also Influenced by Diet in Patients with Psoriasis: A Chronomedical Study.
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Damiani G, Pacifico A, Scoditti E, di Gregorio S, Del Fabbro M, Cozzolino C, Buja A, Mercuri SR, Bianchi VG, Grada A, Garbarino S, and Bunick CG
- Abstract
Introduction: Minimal erythema dose (MED) remains a parameter of paramount importance to orient narrow-band (NB)-UVB phototherapy in psoriatic (PsO) patients. Recently, circadian rhythm and diet were recognized as potential MED modulators, but their mutual interaction remains understudied. Thus, we aimed to evaluate the potential diet modulation of MED circadian oscillations., Methods: In the first phase, a cohort study was performed comparing potential MED oscillations (morning, afternoon, and evening) among omnivorous psoriatic patients before and after a phototherapy cycle and omnivorous healthy controls. The two groups were age-, gender-, skin-type-, MED-, and diet-matched. Then, in the second phase, another cohort study was carried out comparing MED oscillations 24 h after the last phototherapeutic session only in psoriatic patients cleared with NB-UVB and undergoing different diets (vegan, vegetarian, paleo , ketogenic, intermittent circadian fasting, and omnivore). Patients with different diets were age-, gender-, and skin-type matched., Results: In the first phase, we enrolled only omnivores, specifically 54 PsO patients and 54 healthy individuals. Their MED before and after NB-UVB therapy changed significantly among the three different time-points (morning, afternoon, and evening) (p < 0.001). The time effect was statistically significant in both groups before and after phototherapy. In the second phase, we enrolled 144 PsO patients (vegan, vegetarian, paleo, ketogenic, intermittent circadian fasting, and omnivore). MED circadian oscillations preserved a significant difference also after clearance and were influenced by diet type and time of day (p < 0.001). In particular, vegans displayed the lowest MED values, whilst Ramadan fasting showed the highest values in morning, afternoon, and evening., Conclusions: Diet, like other ongoing therapies, should be reported in the medical records of patients with psoriasis undergoing NB-UVB and patients with lower MEDs should be preferentially treated in the morning when the MED is higher., (© 2023. The Author(s).)
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- 2023
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128. Corrigendum: The medium-term perceived impact of work from home on life and work domains of knowledge workers during COVID-19 pandemic: a survey at the National Research Council of Italy.
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Bodini A, Leo CG, Rissotto A, Mincarone P, Fusco S, Garbarino S, Guarino R, Sabina S, Scoditti E, Tumolo MR, and Ponzini G
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[This corrects the article DOI: 10.3389/fpubh.2023.1151009.]., (Copyright © 2023 Bodini, Leo, Rissotto, Mincarone, Fusco, Garbarino, Guarino, Sabina, Scoditti, Tumolo and Ponzini.)
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- 2023
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129. Epigenetic Mechanisms in Vascular Inflammation: Modulation of Endothelial Adhesion Molecules and Endothelium-Leukocyte Adhesion.
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Calabriso N, Massaro M, Scoditti E, Carluccio C, Verri T, and Carluccio MA
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- Humans, Intercellular Adhesion Molecule-1 genetics, Intercellular Adhesion Molecule-1 metabolism, Cell Adhesion genetics, Cell Adhesion Molecules genetics, Cell Adhesion Molecules metabolism, Endothelium metabolism, Leukocytes, Epigenesis, Genetic, Inflammation genetics, Inflammation metabolism, Endothelium, Vascular, Endothelial Cells metabolism, Vascular Cell Adhesion Molecule-1 genetics, Vascular Cell Adhesion Molecule-1 metabolism
- Abstract
The endothelium, an essential component of the vascular system, plays a critical role in the inflammatory response. Under pro-inflammatory stimuli, endothelial cells undergo activation and dysfunction, leading to the release of inflammatory mediators and upregulation of cell adhesion molecules. These changes facilitate the adhesion, rolling, and transmigration of leukocytes into the subendothelial space. Emerging evidence suggests that epigenetic mechanisms, including nucleic acid methylation, post-translational histone modifications, and non-coding RNA, contribute significantly to the regulation of vascular inflammation and expression of cell adhesion molecules. Understanding the epigenetic molecular signatures that govern these processes may provide new insights into the development of therapeutic strategies to combat vascular inflammation and associated diseases. This review aims to summarize the current knowledge on the epigenetic mechanisms involved in modulating the intricate processes underlying vascular inflammation, with a specific focus on the expression of endothelial adhesion molecules and endothelium-leukocyte adhesion., Competing Interests: Given their roles as Guest Editors, Nadia Calabriso and Maria Annunziata Carluccio, had no involvement in the peer-review of this article and have no access to information regarding its peer-review. The authors declare no conflict of interest., (© 2023 The Author(s). Published by IMR Press.)
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- 2023
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130. Hunting for Progressive NAFLD in Type 2 Diabetes: Do Not Trust Liver Enzymes!
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Scoditti E, Marchesini G, and Gastaldelli A
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- Humans, Biopsy, Fibrosis, Liver pathology, Outpatients, Prevalence, Prospective Studies, Diabetes Mellitus, Type 2 epidemiology, Non-alcoholic Fatty Liver Disease epidemiology
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- 2023
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131. Tanshinone IIA and Cryptotanshinone Counteract Inflammation by Regulating Gene and miRNA Expression in Human SGBS Adipocytes.
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Carpi S, Quarta S, Doccini S, Saviano A, Marigliano N, Polini B, Massaro M, Carluccio MA, Calabriso N, Wabitsch M, Santorelli FM, Cecchini M, Maione F, Nieri P, and Scoditti E
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- Humans, Chemokine CXCL10 metabolism, Interleukin-8 metabolism, Inflammation drug therapy, Inflammation genetics, Inflammation metabolism, Tumor Necrosis Factor-alpha metabolism, Adipocytes metabolism, Chemokine CCL5 metabolism, MicroRNAs genetics, MicroRNAs metabolism
- Abstract
Inflammation of the adipose tissue contributes to the onset and progression of several chronic obesity-related diseases. The two most important lipophilic diterpenoid compounds found in the root of Salvia milthorrhiza Bunge (also called Danshen), tanshinone IIA (TIIA) and cryptotanshinone (CRY), have many favorable pharmacological effects. However, their roles in obesity-associated adipocyte inflammation and related sub-networks have not been fully elucidated. In the present study, we investigated the gene, miRNAs and protein expression profile of prototypical obesity-associated dysfunction markers in inflamed human adipocytes treated with TIIA and CRY. The results showed that TIIA and CRY prevented tumor necrosis factor (TNF)-α induced inflammatory response in adipocytes, by counter-regulating the pattern of secreted cytokines/chemokines associated with adipocyte inflammation (CCL2/MCP-1, CXCL10/IP-10, CCL5/RANTES, CXCL1/GRO-α, IL-6, IL-8, MIF and PAI-1/Serpin E1) via the modulation of gene expression (as demonstrated for CCL2/MCP-1, CXCL10/IP-10, CCL5/RANTES, CXCL1/GRO-α, and IL-8), as well as related miRNA expression (miR-126-3p, miR-223-3p, miR-124-3p, miR-155-5p, and miR-132-3p), and by attenuating monocyte recruitment. This is the first demonstration of a beneficial effect by TIIA and CRY on adipocyte dysfunction associated with obesity development and complications, offering a new outlook for the prevention and/or treatment of metabolic diseases.
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- 2023
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132. Dietary Polyphenols and Their Role in Gut Health.
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Calabriso N, Massaro M, Scoditti E, and Carluccio MA
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- Plants metabolism, Biological Availability, Polyphenols pharmacology, Polyphenols metabolism, Biochemical Phenomena
- Abstract
Polyphenols are secondary plant metabolites derived from the shikimate/phenylpropanoid pathway, protecting plants from physical, chemical and biological stress [...].
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- 2023
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133. MIR-29A-3P, MIR-29C-3P, MIR-146B-5P AND MIR-150-5P, Their Target Genes and lncrnas in HIV Infection: A Bioinformatic Study.
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Tumolo MR, Scoditti E, Guarino R, Grassi T, Bagordo F, and Sabina S
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- Humans, Reproducibility of Results, Computational Biology, RNA, Long Noncoding genetics, HIV Infections genetics, MicroRNAs genetics
- Abstract
Introduction: Increasing evidence suggests that microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have emerged as attractive targets in viral infections, including Human immunodeficiency virus (HIV)., Objective: To deepen the understanding of the molecular mechanisms that lead to HIV and provide potential targets for the future development of molecular therapies for its treatment., Methods: Four miRNAs were selected as candidates based on a previous systematic review. A combination of bioinformatic analyses was performed to identify their target genes, lncRNAs and biological processes that regulate them., Results: In the constructed miRNA-mRNA network, 193 gene targets are identified. These miRNAs potentially control genes from several important processes, including signal transduction and cancer. LncRNA-XIST, lncRNA-NEAT1 and lncRNA-HCG18 interact with all four miRNAs., Conclusion: This preliminary result forms the basis for improving reliability in future studies to fully understand the role these molecules and their interactions play in HIV., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
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- 2023
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134. Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans-Evidence from Targeted Nutrigenomic Studies.
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Ruskovska T, Budić-Leto I, Corral-Jara KF, Ajdžanović V, Arola-Arnal A, Bravo FI, Deligiannidou GE, Havlik J, Janeva M, Kistanova E, Kontogiorgis C, Krga I, Massaro M, Miler M, Milosevic V, Morand C, Scoditti E, Suárez M, Vauzour D, and Milenkovic D
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- Adult, Cardiometabolic Risk Factors, Computational Biology, Female, Humans, Male, Metabolic Syndrome genetics, MicroRNAs blood, Middle Aged, Nutrigenomics, RNA, Messenger blood, Real-Time Polymerase Chain Reaction, Signal Transduction genetics, Metabolic Syndrome prevention & control, Nutritional Physiological Phenomena genetics, Polyphenols pharmacology, Protective Agents pharmacology
- Abstract
Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses to elucidate molecular mechanisms underlying the protective effects of polyphenols on cardiometabolic health, we first conducted a systematic literature search to identify human intervention studies with polyphenols that demonstrate improvement of cardiometabolic risk factors in parallel with significant nutrigenomic effects. Applying the predefined inclusion criteria, we identified 58 differentially expressed genes at mRNA level and 5 miRNAs, analyzed in peripheral blood cells with RT-PCR methods. Subsequent integrative bioinformatic analyses demonstrated that polyphenols modulate genes that are mainly involved in the processes such as inflammation, lipid metabolism, and endothelial function. We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1. Integrative bioinformatic analysis of mRNA and miRNA-target pathways demonstrated several common enriched pathways that include MAPK signaling pathway, TNF signaling pathway, PI3K-Akt signaling pathway, focal adhesion, or PPAR signaling pathway. These bioinformatic analyses represent a valuable source of information for the identification of molecular mechanisms underlying the beneficial health effects of polyphenols and potential target genes for future nutrigenetic studies.
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- 2021
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135. Oxidative stress and vascular stiffness in hypertension: A renewed interest for antioxidant therapies?
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Massaro M, Scoditti E, Carluccio MA, and De Caterina R
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- Animals, Enzyme Activation, Humans, Hypertension metabolism, Hypertension physiopathology, Matrix Metalloproteinases metabolism, Antihypertensive Agents therapeutic use, Antioxidants therapeutic use, Arterial Pressure drug effects, Hypertension drug therapy, Oxidative Stress drug effects, Vascular Remodeling drug effects, Vascular Stiffness drug effects
- Abstract
Since the first successful launch of the Veterans Administration(VA) cooperative studies in the late 1960s, the increasing access to blood pressure lowering medications has significantly contributed to improving longevity and quality of life in hypertensive patients. Since then, insights into the pathogenesis of hypertension have shown a mechanistic role for reactive oxygen species (ROS) in all phases of disease progression, suggesting the potential utility of antioxidant therapies to counteract symptoms and, at the same time, treat a fundamental mechanism of the disease. Despite these progresses, hypertension still remains the main contributor to the global incidence of cardiovascular disease and the leading cause of morbidity and mortality worldwide. We here briefly review and update the role of ROS and ROS-dependent metalloproteinase activation in the maladaptive remodeling of the vascular wall in hypertension. Such understanding should provide new Potential sites of action for antioxidant therapies as an integrated therapeutic approach to hypertension and its consequences., (Copyright © 2019. Published by Elsevier Inc.)
- Published
- 2019
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136. Endothelial permeability, LDL deposition, and cardiovascular risk factors-a review.
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Mundi S, Massaro M, Scoditti E, Carluccio MA, van Hinsbergh VWM, Iruela-Arispe ML, and De Caterina R
- Subjects
- Animals, Arteries pathology, Atherosclerosis epidemiology, Atherosclerosis pathology, Biological Transport, Comorbidity, Endothelium, Vascular pathology, Humans, Inflammation Mediators metabolism, Oxidative Stress, Permeability, Plaque, Atherosclerotic, Prognosis, Reactive Oxygen Species metabolism, Risk Factors, Signal Transduction, Smoking adverse effects, Arteries metabolism, Atherosclerosis metabolism, Endothelium, Vascular metabolism, Lipoproteins, LDL metabolism
- Abstract
Early atherosclerosis features functional and structural changes in the endothelial barrier function that affect the traffic of molecules and solutes between the vessel lumen and the vascular wall. Such changes are mechanistically related to the development of atherosclerosis. Proatherogenic stimuli and cardiovascular risk factors, such as dyslipidaemias, diabetes, obesity, and smoking, all increase endothelial permeability sharing a common signalling denominator: an imbalance in the production/disposal of reactive oxygen species (ROS), broadly termed oxidative stress. Mostly as a consequence of the activation of enzymatic systems leading to ROS overproduction, proatherogenic factors lead to a pro-inflammatory status that translates in changes in gene expression and functional rearrangements, including changes in the transendothelial transport of molecules, leading to the deposition of low-density lipoproteins (LDL) and the subsequent infiltration of circulating leucocytes in the intima. In this review, we focus on such early changes in atherogenesis and on the concept that proatherogenic stimuli and risk factors for cardiovascular disease, by altering the endothelial barrier properties, co-ordinately trigger the accumulation of LDL in the intima and ultimately plaque formation., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2018
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137. Nutraceuticals and prevention of atherosclerosis: focus on omega-3 polyunsaturated fatty acids and Mediterranean diet polyphenols.
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Massaro M, Scoditti E, Carluccio MA, and De Caterina R
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- Humans, Polyphenols, Treatment Outcome, Atherosclerosis prevention & control, Cardiovascular Agents therapeutic use, Diet, Mediterranean, Dietary Supplements, Fatty Acids, Omega-3 therapeutic use, Flavonoids therapeutic use, Functional Food, Phenols therapeutic use
- Abstract
Nutraceuticals are potentially healthful foods that play a role in maintaining human well being, enhancing health and preventing, or even treating, specific diseases. More than for any other diseases, cardiovascular diseases occur in association with risk factors that are amenable to prevention or treatment by nutraceutical interventions. Several ingredients marketed for use in dietary supplements address such risk factors. The ability of nutraceuticals to favorably influence cardiovascular risk factors and atherosclerotic vascular disease should be recognized as an enormous opportunity for the prevention or treatment of this common condition. In this review, we attempt at summarizing some of the recent research findings on omega-3-polyunsaturated fatty acids and antioxidant polyphenols that have beneficial cardiovascular effects to update the practicing clinicians on the potential benefits of nutraceuticals in this area.
- Published
- 2010
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138. Omega-3 fatty acids, inflammation and angiogenesis: nutrigenomic effects as an explanation for anti-atherogenic and anti-inflammatory effects of fish and fish oils.
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Massaro M, Scoditti E, Carluccio MA, Montinari MR, and De Caterina R
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- Humans, Fatty Acids, Omega-3 pharmacology, Fish Oils, Genomics, Inflammation prevention & control, Neovascularization, Pathologic prevention & control, Seafood
- Abstract
Atherosclerosis is a dynamic process with inflammatory aspects playing a considerable pathogenetic role. In this process, the vascular endothelium is the key regulator of vascular function, promoting the maintenance of vascular homeostasis or the progression towards vascular disease. In the past 30 years, the dietary intake of omega-3 (n-3) polyunsaturated fatty acids - mainly derived from fish - has emerged as an important way to modify cardiovascular risk through beneficial effects on all stages of atherosclerosis. This review specifically focuses on the modulating effects of n-3 fatty acids on molecular events involved in early and late atherogenesis, including effects on endothelial expression of adhesion molecules, as well as pro-inflammatory and pro-angiogenic enzymes. By accumulating in endothelial membrane phospholipids, omega-3 fatty acids have been shown to decrease the transcriptional activation of several genes through a decreased activation of the nuclear factor-kappaB system of transcription factors. This occurs secondary to decreased generation of intracellular reactive oxygen species. This series of investigations configures a clear example of nutrigenomics, i.e. how nutrients may affect gene expression, ultimately affecting a wide spectrum of human diseases., (Copyright 2007 S. Karger AG, Basel.)
- Published
- 2008
- Full Text
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