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102. Randomized, double-blind, placebo-controlled trial of Tenofovir Alafenamide in children and adolescents with chronic hepatitis B

Author

Schwarz, Kathleen, primary, Bezerra, Jorge, additional, Choe, Byung-Ho, additional, Lin, Chuan-Hao, additional, Abramov, Frida, additional, Nguyen, Anh-Hoa, additional, Liu, Yang, additional, Leisegang, Rory, additional, Flaherty, John F., additional, Pacurar, Daniela, additional, Kim, Kyung Mo, additional, Khaertynova, Shalimar, Ilsiyar, additional, Wu, Jia-Feng, additional, Tandon, Manish, additional, Rosenthal, Philip, additional, Viacheslav, Morozov, additional, Sokal, Etienne, additional, and Chang, Mei-Hwei, additional

Published
2022
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106. Randomized, double-blind, placebo-controlled trial of Tenofovir Alafenamide in children and adolescents with chronic hepatitis B

Author

UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, Schwarz, Kathleen, Bezerra, Jorge, Choe, Byung-Ho, Lin, Chuan-Hao, Abramov, Frida, Nguyen, Anh-Hoa, Liu, Yang, Leisegang, Rory, Flaherty, John, Pacurar, Daniela, Kim, Kyung Mo, Khaertynova, Ilsiyar, Shalimar, Wu,Jia-Feng, Tandon, Manish, Rosenthal, Philip, Viacheslav, Morozov, Sokal, Etienne, Chang, Mei-Hwei, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, Schwarz, Kathleen, Bezerra, Jorge, Choe, Byung-Ho, Lin, Chuan-Hao, Abramov, Frida, Nguyen, Anh-Hoa, Liu, Yang, Leisegang, Rory, Flaherty, John, Pacurar, Daniela, Kim, Kyung Mo, Khaertynova, Ilsiyar, Shalimar, Wu,Jia-Feng, Tandon, Manish, Rosenthal, Philip, Viacheslav, Morozov, Sokal, Etienne, and Chang, Mei-Hwei

Published
2022

115. Randomized, double-blind, placebo-controlled trial of Tenofovir Alafenamide in children and adolescents with chronic hepatitis B

Author

Schwarz, Kathleen, Bezerra, Jorge, Choe, Byung-Ho, Lin, Chuan-Hao, Abramov, Frida, Nguyen, Anh-Hoa, Liu, Yang, Leisegang, Rory, Flaherty, John, Pacurar, Daniela, Kim, Kyung Mo, Khaertynova, Ilsiyar, Shalimar, Wu,Jia-Feng, Tandon, Manish, Rosenthal, Philip, Viacheslav, Morozov, Sokal, Etienne, Chang, Mei-Hwei, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, and UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique

Published
2022

116. The Combination of Ribavirin and Peginterferon Is Superior to Peginterferon and Placebo for Children and Adolescents With Chronic Hepatitis C

Author

Schwarz, Kathleen B., Gonzalez–Peralta, Regino P., Murray, Karen F., Molleston, Jean P., Haber, Barbara A., Jonas, Maureen M., Rosenthal, Philip, Mohan, Parvathi, Balistreri, William F., Narkewicz, Michael R., Smith, Lesley, Lobritto, Steven J., Rossi, Stephen, Valsamakis, Alexandra, Goodman, Zachary, Robuck, Patricia R., and Barton, Bruce A.

Published
2011
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124. P-6 SOFOSBUVIR CONTAINING REGIMENS ARE SAFE AND EFFECTIVE IN ADOLESCENTS WITH CHRONIC HEPATITIS C INFECTION

Author

Wirth, Stefan, Gonzalez-Peralta, Regino, Rosenthal, Philip, Hardikar, Winita, Wen, Jessica, Jonas, Maureen M., Mittal, Naveen, Whitworth, Mary, Arnon, Ronen, Lin, Chuan-Hao, Lobzin, Yury, Romero, Rene, Chulanov, Vladimir, Subbarao, Girish, Teckman, Jeffrey, Morozov, Vyacheslav, Bassetti, Eric, Kersey, Kathryn, Massetto, Benedetta, Zhu, Yanni, German, Polina, Brainard, Diana M., Bansal, Sanjay, Murray, Karen F., Schwarz, Kathleen, and Balistreri, William

Published
2021
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125. Chronic Hepatitis Is Common and Often Untreated Among Children with Hepatitis B Infection in the United States and Canada

Author

Ling, Simon C., primary, Lin, Hsing-Hua S., additional, Murray, Karen F., additional, Rosenthal, Philip, additional, Mogul, Douglas, additional, Rodriguez-Baez, Norberto, additional, Schwarzenberg, Sarah Jane, additional, Teckman, Jeffrey, additional, Schwarz, Kathleen B., additional, Li, Hongxia, additional, Anders, Robert, additional, Imteyaz, Hejab, additional, Lee, Peter, additional, Oshima, Kiyoko, additional, Kafka, Kim, additional, Islam, Naureen, additional, Riggs, Shannon M., additional, Nagy, Rosemary A., additional, Cerkoski, Jacki, additional, Hau, Athena, additional, Cui, Daniel, additional, Rodgers-Augustyniak, Laurie A., additional, Montanye, Shirley, additional, Feier, Natasha, additional, Feier, Joel, additional, Langlois, Camille, additional, Cooper, Kara L., additional, Hoofnagle, Jay H., additional, Sherker, Averell H., additional, Doo, Edward, additional, Torrance, Rebecca J., additional, Hall, Sherry R., additional, Averbach, Frani, additional, Haller, Tamara, additional, Hardison, Regina, additional, Kelley, Stephanie, additional, Lalama, Christina M., additional, Lawlor, Sharon, additional, Lombardero, Manuel, additional, Pelesko, Andrew, additional, Stoliker, Donna, additional, Weiner, Melissa, additional, Zadorozny, Ella, additional, and Zhao, Qian, additional

Published
2021
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126. Recurrence of Primary Sclerosing Cholangitis After Liver Transplant in Children: An International Observational Study

Author

Martinez, Mercedes, primary, Perito, Emily R., additional, Valentino, Pamela, additional, Mack, Cara L, additional, Aumar, Madeleine, additional, Broderick, Annemarie, additional, Draijer, Laura G., additional, Fagundes, Eleonora D.T., additional, Furuya, Katryn N., additional, Gupta, Nitika, additional, Horslen, Simon, additional, Jonas, Maureen M., additional, Kamath, Binita M., additional, Kerkar, Nanda, additional, Kim, Kyung Mo, additional, Kolho, Kaija‐Leena, additional, Koot, Bart G.P., additional, Laborda, Trevor J., additional, Lee, Christine K., additional, Loomes, Kathleen M., additional, Miloh, Tamir, additional, Mogul, Douglas, additional, Mohammed, Saeed, additional, Ovchinsky, Nadia, additional, Rao, Girish, additional, Ricciuto, Amanda, additional, Rodrigues Ferreira, Alexandre, additional, Schwarz, Kathleen B., additional, Smolka, Vratislav, additional, Tanaka, Atsushi, additional, Tessier, Mary E.M., additional, Venkat, Venna L., additional, Vitola, Bernadette E., additional, Woynarowski, Marek, additional, Zerofsky, Melissa, additional, and Deneau, Mark R., additional

Published
2021
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127. Presentation and Outcomes of Infants With Idiopathic Cholestasis: A Multicenter Prospective Study

Author

Hertel, Paula M., primary, Hawthorne, Kieran, additional, Kim, Sehee, additional, Finegold, Milton J., additional, Shneider, Benjamin L., additional, Squires, James E., additional, Gupta, Nitika A., additional, Bull, Laura N., additional, Murray, Karen F., additional, Kerkar, Nanda, additional, Ng, Vicky L., additional, Molleston, Jean P., additional, Bezerra, Jorge A., additional, Loomes, Kathleen M., additional, Taylor, Sarah A., additional, Schwarz, Kathleen B., additional, Turmelle, Yumirle P., additional, Rosenthal, Philip, additional, Magee, John C., additional, and Sokol, Ronald J., additional

Published
2021
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128. The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

Author

Johnson Valiente, Alexandra, primary, Liem, Kin Seng, additional, Schwarz, Kathleen B, additional, Rosenthal, Philip, additional, Murray, Karen F, additional, Mogul, Douglas, additional, Teckman, Jeffery, additional, Rodriguez-Baez, Norberto, additional, Schwarzenberg, Sarah Jane, additional, Feld, Jordan J, additional, Wong, David K, additional, Lewis-Ximenez, Lia L, additional, Lauer, Georg, additional, Hansen, Bettina E, additional, Ling, Simon C, additional, Janssen, Harry L A, additional, and Gehring, Adam J, additional

Published
2021
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129. Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia

Author

Shneider, Benjamin L., Magee, John C., Karpen, Saul J., Rand, Elizabeth B., Narkewicz, Michael R., Bass, Lee M., Schwarz, Kathleen, Whitington, Peter F., Bezerra, Jorge A., Kerkar, Nanda, Haber, Barbara, Rosenthal, Philip, Turmelle, Yumirle P., Molleston, Jean P., Murray, Karen F., Ng, Vicky L., Wang, Kasper S., Romero, Rene, Squires, Robert H., Arnon, Ronen, Sherker, Averell H., Moore, Jeffrey, Ye, Wen, and Sokol, Ronald J.

Published
2016
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133. Changes in serum hepatitis B surface and e antigen, interferon‐inducible protein 10, and aminotransferase levels during combination therapy of immune‐tolerant chronic hepatitis B.

Author

Perrillo, Robert, Lin, Hsing‐Hua S., Schwarz, Kathleen B., Rosenthal, Philip, Lisker‐Melman, Mauricio, Chung, Raymond T., Prokunina‐Olsson, Ludmila, Coherty, Gavin, Feld, Jordan, Lau, Daryl T‐Y, Roberts, Lewis R., Hassan, Mohamed A., Schwarzenberg, Sarah Jane, Di Bisceglie, Adrian M., Teckman, Jeffrey, Janssen, Harry L. A., Wong, David K., Juan, Joshua, Yim, Colina, and Patel, Keyur

Published
2022
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134. 422 ORAL VANCOMYCIN THERAPY IS ASSOCIATED WITH IBD CLINICAL REMISSION IN PEDIATRIC PSC-IBD

Author

Ricciuto, Amanda, primary, Liu, Kuan, additional, Amir, Achiya Z., additional, Aumar, Madeleine, additional, Broderick, Annemarie, additional, Draijer, Laura, additional, El-Matary, Wael, additional, Fagundes, Eleonora D., additional, Ferrari, Federica, additional, Furuya, Katryn, additional, Gupta, Nitika, additional, Horslen, Simon P., additional, Iorio, Raffaele, additional, Jonas, Maureen M., additional, Kamath, Binita M., additional, Kerkar, Nanda, additional, Kim, Kyung Mo, additional, Kolho, Kaija-Leena, additional, Koot, Bart, additional, Laborda, Trevor, additional, Lee, Christine, additional, Loomes, Kathleen, additional, Mack, Cara L., additional, Martinez, Mercedes, additional, Miloh, Tamir, additional, Mogul, Douglas, additional, Mohammad, Saeed, additional, Ovchinsky, Nadia, additional, Palle, Sirish, additional, Perito, Emily, additional, Ferreira, Alexandre Rodrigues, additional, Schwarz, Kathleen B., additional, Rao, Girish S., additional, Tanaka, Atsushi, additional, Valentino, Pamela L., additional, Venkat, Veena, additional, Vitola, Bernadette E., additional, Vratislav, Smolka, additional, Woynarowski, Marek, additional, Zerofsky, Melissa, additional, and Deneau, Mark R., additional

Published
2021
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135. Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver

Author

Traum, Daniel, primary, Wang, Yue J., additional, Schwarz, Kathleen B., additional, Schug, Jonathan, additional, Wong, David K.H., additional, Janssen, Harry L.A., additional, Terrault, Norah A., additional, Khalili, Mandana, additional, Wahed, Abdus S., additional, Murray, Karen F., additional, Rosenthal, Phillip, additional, Ling, Simon C., additional, Rodriguez-Baez, Norberto, additional, Sterling, Richard K., additional, Lau, Daryl T.Y., additional, Block, Timothy M., additional, Feldman, Michael D., additional, Furth, Elizabeth E., additional, Lee, William M., additional, Kleiner, David E., additional, Lok, Anna S., additional, Kaestner, Klaus H., additional, and Chang, Kyong-Mi, additional

Published
2021
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137. THE PRESENCE OF A TRUNCATING MUTATION IN ABCB11 ABROGATES THE BENEFICIAL EFFECT OF A RESIDUAL FUNCTION MUTATION ON THE COURSE OF SEVERE BILE SALT EXPORT PUMP DEFICIENCY

Author

Felzen, Antonia, van Wessel, Daan, Thompson, Richard J., Gonzales, Emmanuel M., Jankowska, Irena, Shneider, Benjamin L., Sokal, Etienne, Grammatikopoulos, Tassos, Kadaristiana, Agustina, Jacquemin, Emmanuel, Spraul, Anne, Lipinski, Patryk, Czubkowski, Piotr, Rock, Nathalie, Shagrani, Mohammad, Broering, Dieter, Algoufi, Talal, Mazhar, Nejat, Nicastro, Emanuele, Kelly, Deirdre, Nebbia, Gabriella, Arnell, Henrik, Fischler, Bjorn, Hulscher, Jan, Serranti, Daniele, Arikan, Cigdem, Polat, Esra, Debray, Dominique, Lacaille, Florence, Goncalves, Cristina, Hierro, Loreto, Bartolo, Gema Munoz, Mozer-Glassberg, Yael, Azaz, Amer, Brecelj, Jernej, Dezsofi, Antal, Calvo, Pier Luigi, Grabhorn, Enke, Hartleif, Steffen, Van der Woerd, Wendy, Kamath, Binita M., Wang, Jian-She, Li, Liting, Durmaz, Ozlem, Kerkar, Nanda, Jorgensen, Marianne Horby, Fischer, Ryan T., Jimenez-Rivera, Carolina, Alam, Seema, Cananzi, Mara, Ruiz, Mathias, Ferreira, Cristina Targa, Ferrero, Felipe Ordonez, Wang, Heng, Sency, Valerie, Kim, Kyung Mo, Chen, Huey-Ling, Carvalho, Elisa, Fabre, Alexandre, Bernabeu, Jesus Quintero, Alonso, Estella M., Sokol, Ronald J., Suchy, Frederick J., Loomes, Kathleen M., McKiernan, Patrick James, Rosenthal, Philip, Turmelle, Yumirle, Horslen, Simon P., Schwarz, Kathleen B., Bezerra, Jorge A., Wang, Kasper S., Hansen, Bettina E., Verkade, Henkjan J., and Center for Liver, Digestive and Metabolic Diseases (CLDM)

Published
2020

138. Sofosbuvir and Ribavirin Therapy for Children 3 to <12 Years Old With Hepatitis C Virus Genotype 2 or 3 Infection

Author

Rosenthal, Philip, Schwarz, Kathleen B., Gonzalez-Peralta, Regino P., Lin, Chuan-Hao, Kelly, Deidre A., Nightingale, Scott, Balistreri, William F., Bansal, Sanjay, Jonas, Maureen M., Massetto, Benedetta, Brainard, Diana M., Hsueh, Chia-Hsiang, Shao, Jiang, Parhy, Bandita, Davison, Suzanne, Feiterna-Sperling, Cornelia, Gillis, Lynette A., Indolfi, Giuseppe, Sokal, Etienne, Murray, Karen F., Wirth, Stefan, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, and UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique

Subjects
Hepatology
Abstract

Currently, the only approved hepatitis C virus (HCV) treatment for children aged

Published
2020

140. Sofosbuvir and Ribavirin Therapy for Children 3 to <12 Years Old With Hepatitis C Virus Genotype 2 or 3 Infection

Author

UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, Rosenthal, Philip, Schwarz, Kathleen B., Gonzalez-Peralta, Regino P., Lin, Chuan-Hao, Kelly, Deidre A., Nightingale, Scott, Balistreri, William F., Bansal, Sanjay, Jonas, Maureen M., Massetto, Benedetta, Brainard, Diana M., Hsueh, Chia-Hsiang, Shao, Jiang, Parhy, Bandita, Davison, Suzanne, Feiterna-Sperling, Cornelia, Gillis, Lynette A., Indolfi, Giuseppe, Sokal, Etienne, Murray, Karen F., Wirth, Stefan, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, Rosenthal, Philip, Schwarz, Kathleen B., Gonzalez-Peralta, Regino P., Lin, Chuan-Hao, Kelly, Deidre A., Nightingale, Scott, Balistreri, William F., Bansal, Sanjay, Jonas, Maureen M., Massetto, Benedetta, Brainard, Diana M., Hsueh, Chia-Hsiang, Shao, Jiang, Parhy, Bandita, Davison, Suzanne, Feiterna-Sperling, Cornelia, Gillis, Lynette A., Indolfi, Giuseppe, Sokal, Etienne, Murray, Karen F., and Wirth, Stefan

Abstract

Currently, the only approved hepatitis C virus (HCV) treatment for children aged <12 years is pegylated-interferon plus ribavirin. In an open-label study, we evaluated the safety and efficacy of sofosbuvir plus ribavirin for 12 weeks in children aged 3 to <12 years chronically infected with genotype 2 or for 24 weeks in patients with genotype 3. Patients aged 3 to <6 years weighing <17 kg received sofosbuvir 150 mg, and patients aged 3 to <6 years weighing ≥17 kg and all patients aged 6 to <12 years received sofosbuvir 200 mg once daily. Intensive pharmacokinetic sampling conducted in each age group confirmed the appropriateness of sofosbuvir doses. For all patients, ribavirin dosing was determined by baseline weight (up to 1400 mg/day, two divided doses). The primary efficacy endpoint was sustained virologic response 12 weeks after therapy (SVR12). 54 patients were enrolled (41 aged 6 to <12 years and 13 aged 3 to <6 years). Most were treatment-naive (98%) and infected perinatally (94%). All but one patient achieved SVR12 (53/54, 98%, 95% CI 90-100%). The patient who did not achieve SVR12 was a 4 year-old who discontinued treatment after three days due to 'abnormal drug taste'. The most commonly reported adverse events in patients aged 6 to <12 years were vomiting (32%) and headache (29%) and in patients aged 3 to <6 years, vomiting (46%) and diarrhea (39%). One 3 year-old patient had a serious adverse event of accidental ribavirin overdose requiring hospitalization for monitoring; this patient completed treatment and achieved SVR12. CONCLUSION: Sofosbuvir plus ribavirin was well-tolerated and highly effective in children aged 3 to <12 years with chronic HCV genotype 2 or 3 infection

Published
2020

141. Oral Vancomycin, Ursodeoxycholic Acid, or No Therapy for Pediatric Primary Sclerosing Cholangitis: A Matched Analysis

Author

Deneau, Mark R., primary, Mack, Cara, additional, Mogul, Douglas, additional, Perito, Emily R., additional, Valentino, Pamela L., additional, Amir, Achiya Z., additional, DiGuglielmo, Matthew, additional, Draijer, Laura G., additional, El‐Matary, Wael, additional, Furuya, Katryn N., additional, Gupta, Nitika, additional, Hochberg, Jessica T., additional, Horslen, Simon, additional, Jensen, M. Kyle, additional, Jonas, Maureen M., additional, Kerkar, Nanda, additional, Koot, Bart G.P., additional, Laborda, Trevor J., additional, Lee, Christine K., additional, Loomes, Kathleen M., additional, Martinez, Mercedes, additional, Miethke, Alexander, additional, Miloh, Tamir, additional, Mohammad, Saeed, additional, Ovchinsky, Nadia, additional, Rao, Girish, additional, Ricciuto, Amanda, additional, Sathya, Pushpa, additional, Schwarz, Kathleen B., additional, Shah, Uzma, additional, Singh, Ruchi, additional, Vitola, Bernadette, additional, Zizzo, Andréanne, additional, and Guthery, Stephen L., additional

Published
2021
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150. List of Contributors

Author

Adler, Stuart P., primary, Alford, Charles A., additional, Arvin, Ann M., additional, Baker, Carol J., additional, Barnett, Elizabeth D., additional, Bendel, Catherine M., additional, K. Benjamin, Daniel, additional, Bortolussi, Robert, additional, Bradley, John S., additional, Britt, William, additional, Cherry, James D., additional, Cleary, Thomas G., additional, Coffin, Susan E., additional, Cooper, Louis Z., additional, Crowe, James E., additional, Cruz, Andrea T., additional, D'Angio, Carl T., additional, Darmstadt, Gary L., additional, Darville, Toni, additional, Desmonts, George, additional, Dobson, Simon, additional, Embree, Joanne E., additional, Gagnon, Amy J., additional, A. Gerber, Michael, additional, Gershon, Anne A., additional, Gibbs, Ronald S., additional, Gutierrez, Kathleen M., additional, Hardy, R. Doug, additional, Karnsakul, Wikrom, additional, Klein, Jerome O., additional, C. Koch, William, additional, Kollmann, Tobias R., additional, Krogstad, Paul, additional, Lewis, David B., additional, Long, Sarah S., additional, Mailman, Timothy L., additional, Maldonado, Yvonne A., additional, McLeod, Rima, additional, McMillan, Julia A., additional, Nataro, James P., additional, Nizet, Victor, additional, L. Ogra, Pearay, additional, O'Ryan, Miguel L., additional, Overturf, Gary D., additional, Plotkin, Stanley A., additional, Ramilo, Octavio, additional, Reef, Susan E., additional, Remington, Jack S., additional, Schwarz, Kathleen B., additional, Shapiro, Eugene D., additional, Shetty, Avinash K., additional, Starke, Jeffrey R., additional, Stoll, Barbara J., additional, Wade, Kelly C., additional, Weinberg, Geoffrey A., additional, Whitley, Richard J., additional, Wilson, Christopher B., additional, Zaidi, Anita K.M., additional, and Zaoutis, Theoklis E., additional

Published
2011
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