20,958 results on '"Savic A"'
Search Results
102. Processing of visual hapaxes in picture naming task: An event-related potential study
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Jovanović, Vojislav, Petrušić, Igor, Savić, Andrej, and Ković, Vanja
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- 2024
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103. Changes in the wing shape and size in fruit flies exposed to micro and nanoplastics
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Sorensen, Rachel M., Savić-Zdravković, Dimitrija, and Jovanović, Boris
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- 2024
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104. Palaeoparasitological evidence for a possible sanitary stone vessel from the Roman city of Viminacium, Serbia
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Marković, Nemanja, Raičković Savić, Angelina, Mitić, Ana, and Mitchell, Piers D.
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- 2024
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105. Status and future scope of hydrogels in wound healing
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Markovic, Maja D., Spasojevic, Pavle M., Pantic, Olga J., Savic, Sanja I., Spasojevic Savkovic, Milica M., and Panic, Vesna V.
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- 2024
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106. Development of new steroid-based hydrazide and (thio)semicarbazone compounds with anticancer properties
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Janković, Ðorđe D., Šestić, Tijana Lj., Bekić, Sofija S., Savić, Marina P., Ćelić, Andjelka S., Scholda, Julia, Kopp, Florian, Marinović, Maja A., Petri, Edward T., and Ajduković, Jovana J.
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- 2024
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107. Tracing Tumor Heterogeneity of Pleomorphic Carcinoma of the Lung
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Roma, Luca, Ercan, Caner, Conticelli, Floriana, Akyürek, Nalan, Savic Prince, Spasenija, Mertz, Kirsten D., Diebold, Joachim, Lardinois, Didier, Piscuoglio, Salvatore, Ng, Charlotte KY., and Bubendorf, Lukas
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- 2024
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108. Target product profiles: tests for tuberculosis treatment monitoring and optimization/ Profils de produits cibles: essais pour le suivi et l'optimisation du traitement de la tuberculose/ Perfiles de productos objetivo: pruebas para el seguimiento y la optimizacion del tratamiento de la tuberculosis
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Gupta-Wright, Ankur, den Boon, Saskia, MacLean, Emily L., Cirillo, Daniela, Cobelens, Frank, Gillespie, Stephen H., Kohli, Mikashmi, Ruhwald, Morten, Savic, Rada, Brigden, Grania, Gidado, Mustapha, Goletti, Delia, Hanna, Debra, Hasan, Rumina, Hewison, Cathy, Koura, Kobto G., Lienhardt, Christian, Lungu, Patrick, McHugh, Timothy D., McKenna, Lindsay, Scott, Cherise, Scriba, Thomas, Sekaggya-Wiltshire, Christine, Kasaeva, Tereza, Zignol, Matteo, Denkinger, Claudia M., and Falzon, Dennis
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Cost benefit analysis -- Surveys ,Tuberculosis -- Surveys ,Public health -- Surveys ,Cost benefit analysis ,Health ,World Health Organization -- Surveys - Abstract
The World Health Organization has developed target product profiles containing minimum and optimum targets for key characteristics for tests for tuberculosis treatment monitoring and optimization. Tuberculosis treatment optimization refers to initiating or switching to an effective tuberculosis treatment regimen that results in a high likelihood of a good treatment outcome. The target product profiles also cover tests of cure conducted at the end of treatment. The development of the target product profiles was informed by a stakeholder survey, a cost-effectiveness analysis and a patient-care pathway analysis. Additional feedback from stakeholders was obtained by means of a Delphi-like process, a technical consultation and a call for public comment on a draft document. A scientific development group agreed on the final targets in a consensus meeting. For characteristics rated of highest importance, the document lists: (i) high diagnostic accuracy (sensitivity and specificity); (ii) time to result of optimally [less than or equal to] 2 hours and no more than 1 day; (iii) required sample type to be minimally invasive, easily obtainable, such as urine, breath, or capillary blood, or a respiratory sample that goes beyond sputum; (iv) ideally the test could be placed at a peripheral-level health facility without a laboratory; and (v) the test should be affordable to low- and middle-income countries, and allow wide and equitable access and scale-up. Use of these target product profiles should facilitate the development of new tuberculosis treatment monitoring and optimization tests that are accurate and accessible for all people being treated for tuberculosis. L'Organisation mondiale de la sante a elabore des profils de produits cibles contenant des cibles minimales et optimales pour les caracteristiques principales des essais destines au suivi et a l'optimisation du traitement de la tuberculose. L'optimisation du traitement de la tuberculose fait reference a l'instauration d'un regime de traitement efficace de la tuberculose ou a l'adoption d'un tel regime, avec une probabilite elevee d'obtenir de bons resultats therapeutiques. Les profils de produits cibles couvrent egalement les essais de guerison effectues a l'issue du traitement. Les profils de produits cibles ont ete elabores sur la base d'un sondage aupres des parties prenantes, d'une analyse cout-efficacite et d'une analyse du parcours de soins du patient. Des retours supplementaires des parties prenantes ont ete obtenus au moyen d'un processus cree selon la methode Delphi, d'une consultation technique et d'un appel a commentaires publics sur un projet de document. Un groupe d'elaboration scientifique s'est mis d'accord sur les objectifs finaux lors d'une reunion de concertation. En ce qui concerne les caracteristiques jugees les plus importantes, le document enumere ce qui suit: (i) une grande precision diagnostique (sensibilite et specificite); (ii) un delai ideal d'obtention des resultats [less than or equal to] 2 heures et au maximum de 1 jour; (iii) le type d'echantillon requis doit etre peu invasif et facile a obtenir, comme l'urine, l'haleine ou le sang capillaire, ou bien un echantillon respiratoire au-dela des expectorations; (iv) idealement, l'essai pourrait avoir lieu dans un etablissement de sante peripherique sans laboratoire ; et (v) l'essai devrait etre abordable pour les pays a revenu faible et intermediaire et permettre un acces large et equitable ainsi qu'une mise a l'echelle. L'utilisation de ces profils de produits cibles devrait faciliter la mise au point de nouveaux essais de surveillance et d'optimisation du traitement de la tuberculose qui soient precis et accessibles a toutes les personnes suivant un traitement pour la tuberculose. La Organizacion Mundial de la Salud ha elaborado perfiles de productos objetivo que contienen objetivos minimos y optimos para las caracteristicas principales de las pruebas de seguimiento y optimizacion del tratamiento de la tuberculosis. La optimizacion del tratamiento de la tuberculosis consiste en iniciar o cambiar a un regimen eficaz de tratamiento de la tuberculosis que ofrezca una alta probabilidad de un buen resultado terapeutico. Los perfiles de productos objetivo tambien abarcan las pruebas de curacion realizadas al final del tratamiento. La elaboracion de los perfiles de los productos objetivo se baso en una encuesta a las partes interesadas, un analisis de rentabilidad y un analisis de la via de atencion al paciente. Se obtuvo informacion adicional de las partes interesadas mediante un proceso tipo Delphi, una consulta tecnica y una convocatoria de comentarios publicos sobre un borrador del documento. Un grupo de desarrollo cientifico acordo los objetivos finales en una reunion de consenso. Para las caracteristicas clasificadas de mayor importancia, el documento enumera: (i) alta precision diagnostica (sensibilidad y especificidad); (ii) tiempo hasta el resultado de optimamente [less than or equal to] 2 horas y no mas de 1 dia; (iii) el tipo de muestra requerida debe ser minimamente invasiva, facil de obtener, como orina, aliento o sangre capilar, o una muestra respiratoria que vaya mas alla del esputo; (iv) idealmente la prueba podria realizarse en un centro sanitario periferico sin laboratorio; y (v) la prueba debe ser asequible para los paises de ingresos bajos y medios y permitir un acceso amplio y equitativo y su expansion. El uso de estos perfiles de producto objetivo deberia facilitar el desarrollo de pruebas nuevas de seguimiento y optimizacion del tratamiento de la tuberculosis que sean precisas y accesibles para todas las personas que reciben tratamiento antituberculoso. [phrase omitted], Introduction Tuberculosis continues to be a major cause of morbidity and mortality globally, despite being curable and preventable. In 2021, an estimated 10.6 million people had tuberculosis disease and 1.6 [...]
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- 2023
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109. Pork quality and histological properties of longissimus muscle from boars and early and late immunocastrated pigs
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Božičković, Ivana, Savić, Radomir, Panella-Riera, Núria, Radojković, Dragan, Brun, Albert, and Font-i-Furnols, Maria
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- 2025
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110. Enhancing inflow and infiltration detection in urban sewer networks with a new deterministic sensor placement method
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Wu, Yuling, Zheng, Feifei, Yang, Yongfei, Zhang, Kaiming, Du, Kun, Duan, Huanfeng, Savic, Dragan, and Kapelan, Zoran
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- 2025
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111. Spectropolarimetry and spectral decomposition of high-accreting Narrow Line Seyfert 1 galaxies
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Śniegowska, Marzena, Panda, Swayamtrupta, Czerny, Bożena, Savić, Đorge, Martínez-Aldama, Mary Loli, Marziani, Paola, Wang, Jian-Min, Du, Pu, Popović, Luka Č., and Saraf, Chandra Shekhar
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Narrow Line Seyfert 1 (NLSy1) galaxies have been shown to have high Eddington ratios and relatively small black hole masses. The measurement of the black hole masses is based on the virial relation which is dependent on the distribution of the line-emitting gas and the viewing angle to the source. Spectropolarimetry enables us to probe the geometry of this line-emitting gas and allows us to estimate independently the viewing angle of the source by comparing the spectrum viewed under natural light and in the polarized light. We performed spectropolarimetric observations of three NLSy1 - Mrk 1044, SDSS J080101.41+184840.7, and IRAS 04416+1215 using the European Southern Observatory's Very Large Telescope. We use ESO Reflex workflow to perform standard data reduction and extract the natural and polarized spectra. We estimate the Stokes parameters and the viewing angles of the three sources. We model the Stokes parameters and infer the properties of the scattering media - located in the equatorial and polar regions, and simulate the spectra observed both in natural light and in polarized light using the polarization radiative transfer code STOKES. We confirm that all three sources are high Eddington ratio objects. We are successful in recovering the observed H$\alpha$ line profile both in the natural and polarized light using the STOKES modelling. We recover the polarization fractions of the order of 0.2-0.5% for the three sources. Our principal component analysis shows that the sample of the 25 sources including our sources, Fairall 9 from Jiang et al. (2021), and sources from Capetti et al. (2021) are mainly driven by the black hole mass and Eddington ratio. We re-affirm the connection of the strength of the optical FeII emission with the Eddington ratio, but the dependence on the viewing angle is moderate, more like a secondary effect., Comment: 25 pages, 21 figures, 11 tables, to be published in Astronomy & Astrophysics, version after proofs
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- 2022
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112. Inherited CD19 Deficiency Does Not Impair Plasma Cell Formation or Response to CXCL12
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Walker, Kieran, Mistry, Anoop, Watson, Christopher M., Nadat, Fatima, O’Callaghan, Eleanor, Care, Matthew, Crinnion, Laura A., Arumugakani, Gururaj, Bonthron, David T., Carter, Clive, Doody, Gina M., and Savic, Sinisa
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- 2023
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113. Mapping analysis to predict SF-6D utilities from health outcomes in people with focal epilepsy
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Flint, India, Medjedovic, Jasmina, Drogon O’Flaherty, Ewa, Alvarez-Baron, Elena, Thangavelu, Karthinathan, Savic, Natasa, Meunier, Aurelie, and Longworth, Louise
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- 2023
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114. Mitigating urban heat island effects using trees in planters with varied crown shapes
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Bajšanski, Ivana, Savić, Stevan, Dunjić, Jelena, Milošević, Dragan, Stojaković, Vesna, and Tepavčević, Bojan
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- 2024
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115. Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models
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zur Nedden, Stephanie, Safari, Motahareh S., Weber, Dido, Kuenkel, Louisa, Garmsiri, Carolin, Lang, Luisa, Orset, Cyrille, Freret, Tom, Haelewyn, Benoît, Hotze, Madlen, Kwiatkowski, Marcel, Sarg, Bettina, Faserl, Klaus, Savic, Dragana, Skvortsova, Ira-Ida, Krogsdam, Anne, Carollo, Sandro, Trajanoski, Zlatko, Oberacher, Herbert, Zlotek, Dominik, Ostermaier, Florian, Cameron, Angus, Baier, Gottfried, and Baier-Bitterlich, Gabriele
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- 2024
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116. Exploring the long-term variations and high concentration episodes of peroxyacetyl nitrate in Megacity Seoul
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Savic, Anja, Gil, Junsu, Cha, Junil, Lee, Meehye, Choi, Yuri, and Park, Moon-Soo
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- 2024
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117. Piperaquine-Induced QTc Prolongation Decreases With Repeated Monthly Dihydroartemisinin-Piperaquine Dosing in Pregnant Ugandan Women
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Hughes, Emma, Wallender, Erika, Kajubi, Richard, Jagannathan, Prasanna, Ochieng, Teddy, Kakuru, Abel, Kamya, Moses R, Clark, Tamara D, Rosenthal, Philip J, Dorsey, Grant, Aweeka, Francesca, and Savic, Radojka M
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Medical Microbiology ,Biomedical and Clinical Sciences ,Prevention ,Rare Diseases ,Malaria ,Clinical Research ,Clinical Trials and Supportive Activities ,Prevention of disease and conditions ,and promotion of well-being ,3.3 Nutrition and chemoprevention ,Reproductive health and childbirth ,Good Health and Well Being ,Antimalarials ,Artemisinins ,Drug Combinations ,Female ,Humans ,Long QT Syndrome ,Malaria ,Falciparum ,Piperazines ,Placenta ,Pregnancy ,Pregnant Women ,Quinolines ,Uganda ,intermittent preventive treatment for malaria in pregnancy ,dihydroartemisinin-piperaquine ,QTc prolongation ,pharmacokinetic/pharmacodynamic modeling ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Clinical sciences - Abstract
BackgroundIntermittent preventive treatment with monthly dihydroartemisinin-piperaquine (DHA-PQ) is highly effective at preventing both malaria during pregnancy and placental malaria. Piperaquine prolongs the corrected QT interval (QTc), and it is possible that repeated monthly dosing could lead to progressive QTc prolongation. Intensive characterization of the relationship between piperaquine concentration and QTc interval throughout pregnancy can inform effective, safe prevention guidelines.MethodsData were collected from a randomized controlled trial, where pregnant Ugandan women received malaria chemoprevention with monthly DHA-PQ (120/960 mg DHA/PQ; n = 373) or sulfadoxine-pyrimethamine (SP; 1500/75 mg; n = 375) during the second and third trimesters of pregnancy. Monthly trough piperaquine samples were collected throughout pregnancy, and pre- and postdose electrocardiograms were recorded at 20, 28, and 36 weeks' gestation in each woman. The pharmacokinetics-QTc relationship for piperaquine and QTc for SP were assessed using nonlinear mixed-effects modeling.ResultsA positive linear relationship between piperaquine concentration and Fridericia corrected QTc interval was identified. This relationship progressively decreased from a 4.42 to 3.28 to 2.13 millisecond increase per 100 ng/mL increase in piperaquine concentration at 20, 28, and 36 weeks' gestation, respectively. Furthermore, 61% (n = 183) of women had a smaller change in QTc at week 36 than week 20. Nine women given DHA-PQ had grade 3-4 cardiac adverse events. SP was not associated with any change in QTc.ConclusionsRepeated DHA-PQ dosing did not result in increased risk of QTc prolongation and the postdose QTc intervals progressively decreased. Monthly dosing of DHA-PQ in pregnant women carries minimal risk of QTc prolongation.Clinical trials registrationNCT02793622.
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- 2022
118. Modeling the Probability of HIV Infection over Time in High-Risk Seronegative Participants Receiving Placebo in Five Randomized Double-Blind Placebo-Controlled HIV Pre-Exposure Prophylaxis Trials: A Patient-Level Pooled Analysis.
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Garcia-Cremades, Maria, Hendrix, Craig W, Jayachandran, Priya, Strydom, Natasha, Jarlsberg, Leah, Grant, Robert, Celum, Connie L, Martin, Michael, Baeten, Jared M, Marrazzo, Jeanne, Anderson, Peter, Choopanya, Kachit, Vanichseni, Suphak, Glidden, David V, and Savic, Radojka M
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HIV prevention trials ,key and vulnerable populations ,modeling ,risk factors ,risk phenotypes ,Clinical Research ,Clinical Trials and Supportive Activities ,HIV/AIDS ,Prevention ,Infectious Diseases ,Sexual and Gender Minorities (SGM/LGBT*) ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Infection ,Good Health and Well Being ,Pharmacology and Pharmaceutical Sciences - Abstract
The World Health Organization recommends pre-exposure prophylaxis (PrEP) for individuals at substantial risk of HIV infection. The aim of this analysis is to quantify the individual risk of HIV infection over time, using a large database of high-risk individuals (n = 5583). We used data from placebo recipients in five phase III PrEP trials: iPrEx, conducted in men who have sex with men and transgender women; VOICE, conducted in young women at high sexual risk; Partners PrEP, conducted in HIV serodiscordant heterosexual couples; TDF2, conducted in high-risk heterosexual men and women; and BTS, conducted in persons who inject drugs. The probability of HIV infection over time was estimated using NONMEM7.4. We identified predictors of HIV risk and found a substantial difference in the risk of infection among and within trial populations, with each study including a mix of low, moderate, and high-risk individuals (p < 0.05). Persons who were female at birth were at a higher risk of HIV infection than people who were male at birth. Final models were integrated in a tool that can assess person-specific risk and simulate cumulative HIV risk over time. These models can be used to optimize future PrEP clinical trials by identifying potential participants at highest risk.
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- 2022
119. Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells
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Csomos, Krisztian, Ujhazi, Boglarka, Blazso, Peter, Herrera, Jose L, Tipton, Christopher M, Kawai, Tomoki, Gordon, Sumai, Ellison, Maryssa, Wu, Kevin, Stowell, Matthew, Haynes, Lauren, Cruz, Rachel, Zakota, Bence, Nguyen, Johnny, Altrich, Michelle, Geier, Christoph B, Sharapova, Svetlana, Dasso, Joseph F, Leiding, Jennifer W, Smith, Grace, Al-Herz, Waleed, de Barros Dorna, Mayra, Fadugba, Olajumoke, Fronkova, Eva, Kanderova, Veronika, Svaton, Michael, Henrickson, Sarah E, Hernandez, Joseph D, Kuijpers, Taco, Kandilarova, Snezhina Mihailova, Naumova, Elizaveta, Milota, Tomas, Sediva, Anna, Moshous, Despina, Neven, Benedicte, Saco, Tara, Sargur, Ravishankar, Savic, Sinisa, Sleasman, John, Sunkersett, Gauri, Ward, Brant R, Komatsu, Masanobu, Pittaluga, Stefania, Kumanovics, Attila, Butte, Manish J, Cancro, Michael P, Pillai, Shiv, Meffre, Eric, Notarangelo, Luigi D, and Walter, Jolan E
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Biotechnology ,Infectious Diseases ,1.1 Normal biological development and functioning ,Underpinning research ,B-Lymphocytes ,Cell Differentiation ,DNA-Binding Proteins ,Homeodomain Proteins ,Humans ,Immune Tolerance ,Lymphocyte Count ,Nuclear Proteins ,Immunology - Abstract
The recombination-activating genes (RAG) 1 and 2 are indispensable for diversifying the primary B cell receptor repertoire and pruning self-reactive clones via receptor editing in the bone marrow; however, the impact of RAG1/RAG2 on peripheral tolerance is unknown. Partial RAG deficiency (pRD) manifesting with late-onset immune dysregulation represents an 'experiment of nature' to explore this conundrum. By studying B cell development and subset-specific repertoires in pRD, we demonstrate that reduced RAG activity impinges on peripheral tolerance through the generation of a restricted primary B cell repertoire, persistent antigenic stimulation and an inflammatory milieu with elevated B cell-activating factor. This unique environment gradually provokes profound B cell dysregulation with widespread activation, remarkable extrafollicular maturation and persistence, expansion and somatic diversification of self-reactive clones. Through the model of pRD, we reveal a RAG-dependent 'domino effect' that impacts stringency of tolerance and B cell fate in the periphery.
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- 2022
120. Model‐informed drug development of voxelotor in sickle cell disease: Population pharmacokinetics in whole blood and plasma
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Savic, Radojka M, Green, Michelle L, Jorga, Karin, Zager, Michael, and Washington, Carla B
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Biomedical and Clinical Sciences ,Clinical Sciences ,Rare Diseases ,Hematology ,Sickle Cell Disease ,Clinical Research ,Development of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Adolescent ,Adult ,Aged ,Anemia ,Sickle Cell ,Benzaldehydes ,Drug Development ,Humans ,Models ,Biological ,Pyrazines ,Pyrazoles ,Pharmacology and Pharmaceutical Sciences ,Medical Physiology ,Medical physiology ,Pharmacology and pharmaceutical sciences - Abstract
Oxbryta (voxelotor) is a small-molecule inhibitor of sickle hemoglobin (Hb) polymerization approved for patients with sickle cell disease (SCD) aged greater than or equal to 12 years at a dose of 1500 mg once daily (q.d.). Voxelotor binds preferentially to Hb, and voxelotor partitioning into red blood cells is an effective predictor of Hb occupancy. The objectives of these analyses were to develop a population pharmacokinetic (PopPK) model for voxelotor in both plasma and whole blood in adults and adolescents to support the dose selection for optimal target engagement and to identify covariates that have a significant effect on voxelotor pharmacokinetics (PK) in plasma and whole blood. An integrated plasma and whole blood PopPK model with two compartments, first-order absorption and elimination, and a site-of-action effect compartment adequately described the concentration-time profiles of voxelotor in plasma and whole blood in patients treated up to 72 weeks. Covariates with significant effects on voxelotor PK included baseline blood volume on apparent volume of the central compartment and time-varying hematocrit and dose on whole blood partitioning, indicating that clinical markers of voxelotor effect can, in turn, influence its PK. Furthermore, the model confirmed that voxelotor PK in plasma and whole blood is linear with dose and time and comparable for adults and adolescents. No clinically important covariate effects on voxelotor PK that warranted dose adjustment were identified in this analysis. Overall, the PopPK analyses contributed significantly to the voxelotor label and support 1500 mg q.d. as the therapeutic dose in adults and adolescents with SCD.
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- 2022
121. Model‐informed drug development of voxelotor in sickle cell disease: Exposure‐response analysis to support dosing and confirm mechanism of action
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Green, Michelle L, Savic, Radojka M, Tonda, Margaret, Jorga, Karin, and Washington, Carla B
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Biomedical and Clinical Sciences ,Clinical Sciences ,Rare Diseases ,Clinical Trials and Supportive Activities ,Orphan Drug ,Clinical Research ,Sickle Cell Disease ,Hematology ,6.1 Pharmaceuticals ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,Evaluation of treatments and therapeutic interventions ,Blood ,Adolescent ,Adult ,Anemia ,Sickle Cell ,Benzaldehydes ,Drug Development ,Hemoglobin ,Sickle ,Hemoglobins ,Hemolysis ,Humans ,Pyrazines ,Pyrazoles ,Pharmacology and Pharmaceutical Sciences ,Medical Physiology ,Medical physiology ,Pharmacology and pharmaceutical sciences - Abstract
Sickle cell disease (SCD) is characterized by the production of sickle hemoglobin (HbS), which when deoxygenated, polymerizes leading to red blood cell damage and hemolytic anemia, a defining feature of SCD. Voxelotor (Oxbryta) is a small molecule inhibitor of HbS polymerization that disrupts the polymerization mechanism by binding HbS to increase HbS oxygen affinity. Voxelotor is approved in the United States for the treatment of SCD in patients greater than or equal to 12 years of age at a 1500 mg once-daily (q.d.) dose. These exposure-response analyses aimed to evaluate the relationships between voxelotor whole blood concentration and change from baseline (CFB) in clinical measures of anemia and hemolysis and between voxelotor whole blood and plasma concentrations and the incidence of selected safety end points to confirm the voxelotor mechanism of action and to support the clinical dose recommendation. In patients treated with voxelotor up to 72 weeks, CFB hemoglobin (Hb) increased linearly (p < 0.001) with increasing voxelotor concentration and percent Hb occupancy and increases in CFB Hb corresponded to improvements in measures of hemolysis. The target 1 g/dl increase in CFB Hb was achieved with 1500 mg voxelotor q.d. Significant relationships were observed between voxelotor exposures and grade greater than or equal to 1 increased alanine aminotransferase and decreased white blood cell count; however, most events were grade 1. No clinically important covariate effects on voxelotor efficacy or safety were observed. Overall, these analyses support 1500 mg q.d. as the therapeutic dose for voxelotor in adults and adolescents.
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- 2022
122. Clinical standards for the dosing and management of TB drugs
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Alffenaar, JWC, Stocker, SL, Forsman, L Davies, Garcia-Prats, A, Heysell, SK, Aarnoutse, RE, Akkerman, OW, Aleksa, A, van Altena, R, de Oñata, W Arrazola, Bhavani, PK, Boveneind-Vrubleuskaya, N van T, Carvalho, ACC, Centis, R, Chakaya, JM, Cirillo, DM, Cho, JG, D’Ambrosio, L, Dalcolmo, MP, Denti, P, Dheda, K, Fox, GJ, Hesseling, AC, Kim, HY, Köser, CU, Marais, BJ, Margineanu, I, Märtson, AG, Torrico, M Munoz, Nataprawira, HM, Ong, CWM, Otto-Knapp, R, Peloquin, CA, Silva, DR, Ruslami, R, Santoso, P, Savic, RM, Singla, R, Svensson, EM, Skrahina, A, van Soolingen, D, Srivastava, S, Tadolini, M, Tiberi, S, Thomas, TA, Udwadia, ZF, Vu, DH, Zhang, W, Mpagama, SG, Schön, T, and Migliori, GB
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Rare Diseases ,Orphan Drug ,Clinical Research ,Antimicrobial Resistance ,Patient Safety ,7.3 Management and decision making ,Management of diseases and conditions ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Development of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Good Health and Well Being ,Humans ,Drug Monitoring ,Patient Care ,Reference Standards ,Tuberculosis ,Antitubercular Agents ,tuberculosis ,pharmacokinetics ,pharmacodynamics ,adverse drug reaction ,management ,dosing ,Cardiorespiratory Medicine and Haematology ,Microbiology - Abstract
BACKGROUND: Optimal drug dosing is important to ensure adequate response to treatment, prevent development of drug resistance and reduce drug toxicity. The aim of these clinical standards is to provide guidance on 'best practice´ for dosing and management of TB drugs.METHODS: A panel of 57 global experts in the fields of microbiology, pharmacology and TB care were identified; 51 participated in a Delphi process. A 5-point Likert scale was used to score draft standards. The final document represents the broad consensus and was approved by all participants.RESULTS: Six clinical standards were defined: Standard 1, defining the most appropriate initial dose for TB treatment; Standard 2, identifying patients who may be at risk of sub-optimal drug exposure; Standard 3, identifying patients at risk of developing drug-related toxicity and how best to manage this risk; Standard 4, identifying patients who can benefit from therapeutic drug monitoring (TDM); Standard 5, highlighting education and counselling that should be provided to people initiating TB treatment; and Standard 6, providing essential education for healthcare professionals. In addition, consensus research priorities were identified.CONCLUSION: This is the first consensus-based Clinical Standards for the dosing and management of TB drugs to guide clinicians and programme managers in planning and implementation of locally appropriate measures for optimal person-centred treatment to improve patient care.
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- 2022
123. Experience and Maturation: The Contribution of Co-Occurrence Regularities in Language to the Development of Semantic Organization
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National Institutes of Health (NIH) (DHHS), Savic, Olivera, Unger, Layla, and Sloutsky, Vladimir M.
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With development knowledge becomes organized according to semantic links, including early-developing associative (e.g., juicy-apple) and gradually developing taxonomic links (e.g., apple-pear). Word co-occurrence regularities may foster these links: Associative links may form from direct co-occurrence (e.g., juicy-apple), and taxonomic links from shared co-occurrence (e.g., apple and pear co-occur with juicy). Four experiments (2017-2020) investigated this possibility with 4- to 8-year-olds (N = 148, 82 female) and adults (N = 116, 35 female) in a U.S. city with 58.6% White; 29.0% Black, and 5.8% Asian demographics. Results revealed earlier development of the abilities to form direct (ds > 0.536) than the abilities to form shared co-occurrence-based links (ds > 1.291). We argue that the asynchronous development of abilities to form co-occurrence-based links may explain developmental changes in semantic organization.
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- 2023
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124. Edition Medienwissenschaft: Architectonic Studies of Electromagnetic Milieux
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Selena Savic
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- 2024
125. Mathematical Creativity: A Developmental Perspective. Research in Mathematics Education
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Chamberlin, Scott A., Liljedahl, Peter, Savic, Miloš, Chamberlin, Scott A., Liljedahl, Peter, and Savic, Miloš
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This book is important and makes a unique contribution in the field of mathematics education and creativity. The book comprises the most recent research by renowned international experts and scholars, as well as a comprehensive up to date literature review. The developmental lens applied to the research presented makes it unique in the field. Also, this book provides a discussion of future directions for research to complement what is already known in the field of mathematical creativity. Finally, a critical discussion of the importance of the literature in relation to development of learners and accordingly pragmatic applications for educators is provided. Many books provide the former (2) foci, but omit the final discussion of the research in relation to developmental needs of learners in the domain of mathematics. Currently, educators are expected to implement best practices and illustrate how their adopted approaches are supported by research. The authors and editors of this book have invested significant effort in merging theory with practice to further this field and develop it for future generations of mathematics learners, teachers and researchers.
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- 2022
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126. Management and treatment of perioperative hypersensitivity
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Littlejohns, Anna and Savic, Louise
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- 2024
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127. Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study
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Mitrović, Jelena R., Bjelošević Žiberna, Maja, Vukadinović, Aleksandar, Knutson, Daniel E., Sharmin, Dishary, Kremenović, Aleksandar, Ahlin Grabnar, Pegi, Planinšek, Odon, Lunter, Dominique, Cook, James M., Savić, Miroslav M., and Savić, Snežana D.
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- 2023
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128. Polarization in broad emission lines of Active Galactic Nuclei
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Popović, L. C., Shablovinskaya, E., and Savić, Dj.
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Astrophysics - Astrophysics of Galaxies - Abstract
We discuss the polarization of broad emission lines in the type 1 active galactic nuclei (AGNs). The polarization depends on the geometry of the broad line region (BLR), and also on the polarization mechanism, or distribution of the scattering material. Therefore the polarization measurements can indicate the geometry of the BLR and the mechanism of polarization (equatorial or polar scattering). In addition, the polarization angle (PA) shape across the line profile can be used to measure the supermassive black hole (SMBH) mass, and constrain the BLR characteristics. We give an overview of ours and other recent investigations of the polarization in broad lines from both aspects: theoretical and observational., Comment: accepted in Ast.Nach. This review was present at 13th SCSLSA in a special session dedicated to the memory of Victor Leonidovich Afanasiev who passed away in December 2020
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- 2021
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129. When heart beats differently in depression: a review of HRV measures
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Čukić, Milena, Savić, Danka, and Sidorova, Julia
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Quantitative Biology - Neurons and Cognition - Abstract
Background and Objective: The connection between depression and autonomous nervous system (ANS) is well documented in scientific literature. Heart rate variability (HRV) is a rich source of information for studying the dynamics of this relation. Disturbed heart dynamics in depression seriously increases mortality risk. Technical sciences help improve early detection and monitoring and offer more accurate management of treatment. Based on advances in computational power, information theory, complex systems dynamics, and nonlinear analysis applied to physiological complexity, we can now turn to novel biomarkers extracted from electrophysiological signals. This work is a cross-sectional analysis with methodological commentary of application of nonlinear measures of HRV related to depression. Methods: We systematically searched online for papers exploring the connection of depression and HRV, using both conventional and nonlinear analysis. We scrutinized chosen publications and methodologically analyzed and compared them. Results: Sixty-seven publications on the connection of HRV measures and depression meeting our inclusion criteria are selected. The effectiveness of the applied methods of electrocardiogram (ECG) analysis are compared and discussed in the light of detection and prevention of depression-related cardiac diseases. Conclusions: It is clear that aberrated ANS dynamics can be detected via ECG analysis, where nonlinear measures show to be more sensitive and accurate than standard time and spectral ones. With the portable ECG devices and cloud-based telehealth applications, monitoring of outpatients could be done anytime anywhere. We appeal for early screening for cardiovascular abnormalities in depressive patients to prevent possible deleterious events., Comment: 30 pages, 0 figures, 1 Table
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- 2021
130. The first supermassive black hole mass measurement in active galactic nuclei using the polarization of broad emission line Mg II
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Savić, Đorđe, Popović, Luka Č., and Shablovinskaya, Elena
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Spectropolarimetric efforts in the last few years have provided an efficient method that is based on the profiles of the polarization plane position angle of broad emission lines in active galactic nuclei (AGNs). Here we present black hole measurements of SBS 1419+538 using spectropolarimetric observations in the Mg II spectral band. The observations are performed by 6m telescope of SAO RAS using SCORPIO-2. We found a good agreement for the estimated supermassive black hole (SMBH) mass for this object using spectropolarimetry when compared with the mass obtained using other methods., Comment: Accepted by ApJL on the 24th of September 2021, 7 pages, 3 figures
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- 2021
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131. Photo-induced plasmon-phonon coupling in PbTe
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Jiang, M. P., Trigo, M., Fahy, S., Hauber, A., Murray, É. D., Savić, I, Bray, C., Clark, J. N., Henighan, T., Kozina, M., Chollet, M., Glownia, J. M., Hoffmann, M. C., Zhu, D., Delaire, O., May, A. F., Sales, B. C., Lindenberg, A. M., Zalden, P., Sato, T., Merlin, R., and Reis, D. A.
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Condensed Matter - Materials Science - Abstract
We report the observation of photo-induced plasmon-phonon coupled modes in the group IV-VI semiconductor PbTe using Fourier-transform inelastic X-ray scattering at the Linac Coherent Light Source (LCLS). We measure the near-zone-center dispersion of the heavily screened longitudinal optical (LO) phonon branch as extracted from differential changes in x-ray diffuse scattering intensity following above band gap photoexcitation., Comment: 5 pages, 2 figures
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- 2021
132. Mapping the path to excellence: Evaluation of the diagnostic and treatment tools for invasive fungal infections in the balkans
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Dumitru, Irina-Magdalena, Stathi, Angeliki, Mandros, Charalampos, Travar, Maja, Milobratović, Danica, Mantzana, Paraskevi, Zaharia, Mihaela, Ostojić, Alen, Chatzimsochou, Athanasios, Tonkić, Marija, Otašević, Suzana, Jovanović, Danijela, Vukosavljević, Nikola, Bukovski, Suzana, Philipova, Ivva, Laura, Vlad Jeni, Savić, Aleksandar, Lupse, Mihaela, Manuela, Arbune, Dimova, Diana, Cviljević, Sabina, Orfanidou, Maria, Paramythiotou, Elisabeth, Cheran, Cristina Alexandra, Gartzonika, Konstantina, Skvarc, Miha, Nikolcheva-Todorova, Lidiya, Velikova, Tsvetelina, Panopoulou, Maria, Tihic, Nijaz, Bibić, Tamara, Tomic, Viktorija, Daniela, Serban Elena, Donchev, Krasimir, Sular, Floredana, Moroti, Ruxandra, Voichiţa, Lăzureanu Elena, Valković, Toni, Maraki, Sofija, Pantić, Nikola, Barać, Aleksandra, Mano, Vasilika, Dedeić-Ljubović, Amela, Malkodanski, Ivan, Jaksić, Ozren, Gkentzi, Despoina, Mitrović, Mirjana, Munteanu, Oxana, Šišević, Dijana, Stojanoski, Zlate, Popescu, Oana, Todorović, Jelena, Cornely, Oliver A., and Salmanton-García, Jon
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- 2024
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133. Natural deep eutectic solvents-mediated extraction of rosmarinic acid from Lamiaceae plants: Enhanced extractability and anti-inflammatory potential
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Jurić, Tatjana, Ždero Pavlović, Ružica, Uka, Denis, Beara, Ivana, Majkić, Tatjana, Savić, Sara, Žekić, Marina, and Popović, Boris M.
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134. Automated identification of aquatic insects: A case study using deep learning and computer vision techniques
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Simović, Predrag, Milosavljević, Aleksandar, Stojanović, Katarina, Radenković, Milena, Savić-Zdravković, Dimitrija, Predić, Bratislav, Petrović, Ana, Božanić, Milenka, and Milošević, Djuradj
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- 2024
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135. Main features and disease outcome of congenital myotonic dystrophy - experience from a single tertiary center
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Ostojić, Slavica, Kovačević, Gordana, Meola, Giovanni, Pešović, Jovan, Savić-Pavićević, Dušanka, Brkušanin, Miloš, Kravljanac, Ružica, Perić, Marina, Martić, Jelena, Pejić, Katarina, Ristić, Snežana, and Perić, Stojan
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- 2024
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136. Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach
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Živančević, Katarina, Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Kotur-Stevuljević, Jelena, Ivanišević, Jasmina, Savić, Miroslav, Batinić, Bojan, Janković, Radmila, Djordjevic, Aleksandra Buha, Miljaković, Evica Antonijević, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, and Đukić-Ćosić, Danijela
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- 2024
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137. Immortalized human myotonic dystrophy type 1 muscle cell lines to address patient heterogeneity
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Núñez-Manchón, Judit, Capó, Júlia, Martínez-Piñeiro, Alicia, Juanola, Eduard, Pesovic, Jovan, Mosqueira-Martín, Laura, González-Imaz, Klaudia, Maestre-Mora, Pau, Odria, Renato, Savic-Pavicevic, Dusanka, Vallejo-Illarramendi, Ainara, Mamchaoui, Kamel, Bigot, Anne, Mouly, Vincent, Suelves, Mònica, and Nogales-Gadea, Gisela
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- 2024
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138. Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite
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Panic, Vesna V., Jovanovic, Jelena D., Spasojevic, Jelena P., Savic, Sanja I., Markovic, Maja D., Radulovic, Aleksandra M., and Adnadjevic, Borivoj K.
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- 2024
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139. Loss of MTAP Expression by Immunohistochemistry Is a Surrogate Marker for Homozygous 9p21.3 Deletion in Urothelial Carcinoma
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Vlajnic, Tatjana, Chijioke, Obinna, Roma, Luca, Savic Prince, Spasenija, Zellweger, Tobias, Rentsch, Cyrill A., and Bubendorf, Lukas
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- 2024
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140. Impact of optical fiber-based photo-activation on dental composite polymerization
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Novta, Evgenije, Pantelić, Dejan, Blažić, Larisa, Tóth, Elvira, Cvejić, Željka, Grujić, Dušan, Savić-Šević, Svetlana, and Lainović, Tijana
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- 2024
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141. Making Waves: Towards data-centric water engineering
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Fu, Guangtao, Savic, Dragan, and Butler, David
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- 2024
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142. Chlorophyllin sodium copper salt in hydrogel formulations: spectrophotometric stability studies and in vitro release
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Petrovic, Sanja M., Savic, Sanela M., Savic, Sasa R., Zvezdanovic, Jelena B., and Barbinta-Patrascu, Marcela-Elisabeta
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- 2023
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143. Erratum to: Search for exclusive Higgs and Z boson decays to ϕγ and ργ with the ATLAS detector
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Aaboud, M., Aad, G., Abbott, B., Abdinov, O., Abeloos, B., Abidi, S. H., AbouZeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abreu, R., Abulaiti, Y., Acharya, B. S., Adachi, S., Adamczyk, L., Adelman, J., Adersberger, M., Adye, T., Affolder, A. A., Afik, Y., Agatonovic-Jovin, T., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahlen, S. P., Ahmadov, F., Aielli, G., Akatsuka, S., Akerstedt, H., Åkesson, T. P. A., Akilli, E., Akimov, A. V., Alberghi, G. L., Albert, J., Albicocco, P., Alconada Verzini, M. J., Alderweireldt, S. C., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexander, G., Alexopoulos, T., Alhroob, M., Ali, B., Aliev, M., Alimonti, G., Alison, J., Alkire, S. P., Allbrooke, B. M. M., Allen, B. W., Allport, P. P., Aloisio, A., Alonso, A., Alonso, F., Alpigiani, C., Alshehri, A. A., Alstaty, M. I., Alvarez Gonzalez, B., Álvarez Piqueras, D., Alviggi, M. G., Amadio, B. T., Amaral Coutinho, Y., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amoroso, S., Amundsen, G., Anastopoulos, C., Ancu, L. S., Andari, N., Andeen, T., Anders, C. F., Anders, J. K., Anderson, K. J., Andreazza, A., Andrei, V., Angelidakis, S., Angelozzi, I., Angerami, A., Anisenkov, A. V., Anjos, N., Annovi, A., Antel, C., Antonelli, M., Antonov, A., Antrim, D. J., Anulli, F., Aoki, M., Aperio Bella, L., Arabidze, G., Arai, Y., Araque, J. P., Araujo Ferraz, V., Arce, A. T. H., Ardell, R. E., Arduh, F. A., Arguin, J-F., Argyropoulos, S., Arik, M., Armbruster, A. J., Armitage, L. J., Arnaez, O., Arnold, H., Arratia, M., Arslan, O., Artamonov, A., Artoni, G., Artz, S., Asai, S., Asbah, N., Ashkenazi, A., Asquith, L., Assamagan, K., Astalos, R., Atkinson, M., Atlay, N. B., Augsten, K., Avolio, G., Axen, B., Ayoub, M. K., Azuelos, G., Baas, A. E., Baca, M. J., Bachacou, H., Bachas, K., Backes, M., Bagnaia, P., Bahmani, M., Bahrasemani, H., Baines, J. T., Bajic, M., Baker, O. K., Bakker, P. J., Baldin, E. M., Balek, P., Balli, F., Balunas, W. K., Banas, E., Bandyopadhyay, A., Banerjee, Sw., Bannoura, A. A. E., Barak, L., Barberio, E. L., Barberis, D., Barbero, M., Barillari, T., Barisits, M.-S., Barkeloo, J. T., Barklow, T., Barlow, N., Barnes, S. L., Barnett, B. M., Barnett, R. M., Barnovska-Blenessy, Z., Baroncelli, A., Barone, G., Barr, A. J., Barranco Navarro, L., Barreiro, F., Barreiro Guimarães da Costa, J., Bartoldus, R., Barton, A. E., Bartos, P., Basalaev, A., Bassalat, A., Bates, R. L., Batista, S. J., Batley, J. R., Battaglia, M., Bauce, M., Bauer, F., Bawa, H. S., Beacham, J. B., Beattie, M. D., Beau, T., Beauchemin, P. H., Bechtle, P., Beck, H. P., Beck, H. C., Becker, K., Becker, M., Becot, C., Beddall, A. J., Beddall, A., Bednyakov, V. A., Bedognetti, M., Bee, C. P., Beermann, T. A., Begalli, M., Begel, M., Behr, J. K., Bell, A. S., Bella, G., Bellagamba, L., Bellerive, A., Bellomo, M., Belotskiy, K., Beltramello, O., Belyaev, N. L., Benary, O., Benchekroun, D., Bender, M., Benekos, N., Benhammou, Y., Benhar Noccioli, E., Benitez, J., Benjamin, D. P., Benoit, M., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Bergeaas Kuutmann, E., Berger, N., Bergsten, L. J., Beringer, J., Berlendis, S., Bernard, N. R., Bernardi, G., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Bertella, C., Bertoli, G., Bertram, I. A., Bertsche, C., Besjes, G. J., Bessidskaia Bylund, O., Bessner, M., Besson, N., Bethani, A., Bethke, S., Betti, A., Bevan, A. J., Beyer, J., Bianchi, R. M., Biebel, O., Biedermann, D., Bielski, R., Bierwagen, K., Biesuz, N. V., Biglietti, M., Billoud, T. R. V., Bilokon, H., Bindi, M., Bingul, A., Bini, C., Biondi, S., Bisanz, T., Bittrich, C., Bjergaard, D. M., Black, J. E., Black, K. M., Blair, R. E., Blazek, T., Bloch, I., Blocker, C., Blue, A., Blumenschein, U., Blunier, Dr., Bobbink, G. J., Bobrovnikov, V. S., Bocchetta, S. S., Bocci, A., Bock, C., Boehler, M., Boerner, D., Bogavac, D., Bogdanchikov, A. G., Bohm, C., Boisvert, V., Bokan, P., Bold, T., Boldyrev, A. S., Bolz, A. E., Bomben, M., Bona, M., Boonekamp, M., Borisov, A., Borissov, G., Bortfeldt, J., Bortoletto, D., Bortolotto, V., Boscherini, D., Bosman, M., Bossio Sola, J. D., Boudreau, J., Bouhova-Thacker, E. V., Boumediene, D., Bourdarios, C., Boutle, S. K., Boveia, A., Boyd, J., Boyko, I. R., Bozson, A. J., Bracinik, J., Brandt, A., Brandt, G., Brandt, O., Braren, F., Bratzler, U., Brau, B., Brau, J. E., Breaden Madden, W. D., Brendlinger, K., Brennan, A. J., Brenner, L., Brenner, R., Bressler, S., Briglin, D. L., Bristow, T. M., Britton, D., Britzger, D., Brochu, F. M., Brock, I., Brock, R., Brooijmans, G., Brooks, T., Brooks, W. K., Brosamer, J., Brost, E., Broughton, J. H., Bruckman de Renstrom, P. A., Bruncko, D., Bruni, A., Bruni, G., Bruni, L. S., Bruno, S., Brunt, B. H., Bruschi, M., Bruscino, N., Bryant, P., Bryngemark, L., Buanes, T., Buat, Q., Buchholz, P., Buckley, A. G., Budagov, I. A., Buehrer, F., Bugge, M. K., Bulekov, O., Bullock, D., Burch, T. J., Burdin, S., Burgard, C. D., Burger, A. M., Burghgrave, B., Burka, K., Burke, S., Burmeister, I., Burr, J. T. P., Büscher, D., Büscher, V., Bussey, P., Butler, J. M., Buttar, C. M., Butterworth, J. M., Butti, P., Buttinger, W., Buzatu, A., Buzykaev, A. R., Cabrera Urbán, S., Caforio, D., Cai, H., Cairo, V. M., Cakir, O., Calace, N., Calafiura, P., Calandri, A., Calderini, G., Calfayan, P., Callea, G., Caloba, L. P., Calvente Lopez, S., Calvet, D., Calvet, S., Calvet, T. P., Camacho Toro, R., Camarda, S., Camarri, P., Cameron, D., Caminal Armadans, R., Camincher, C., Campana, S., Campanelli, M., Camplani, A., Campoverde, A., Canale, V., Cano Bret, M., Cantero, J., Cao, T., Capeans Garrido, M. D. M., Caprini, I., Caprini, M., Capua, M., Carbone, R. M., Cardarelli, R., Cardillo, F., Carli, I., Carli, T., Carlino, G., Carlson, B. T., Carminati, L., Carney, R. M. D., Caron, S., Carquin, E., Carrá, S., Carrillo-Montoya, G. D., Casadei, D., Casado, M. P., Casha, A. F., Casolino, M., Casper, D. W., Castelijn, R., Castillo Gimenez, V., Castro, N. F., Catinaccio, A., Catmore, J. R., Cattai, A., Caudron, J., Cavaliere, V., Cavallaro, E., Cavalli, D., Cavalli-Sforza, M., Cavasinni, V., Celebi, E., Ceradini, F., Cerda Alberich, L., Cerqueira, A. S., Cerri, A., Cerrito, L., Cerutti, F., Cervelli, A., Cetin, S. A., Chafaq, A., Chakraborty, D., Chan, S. K., Chan, W. S., Chan, Y. L., Chang, P., Chapman, J. D., Charlton, D. G., Chau, C. C., Chavez Barajas, C. A., Che, S., Cheatham, S., Chegwidden, A., Chekanov, S., Chekulaev, S. V., Chelkov, G. A., Chelstowska, M. A., Chen, C., Chen, C., Chen, H., Chen, J., Chen, S., Chen, S., Chen, X., Chen, Y., Cheng, H. C., Cheng, H. J., Cheplakov, A., Cheremushkina, E., Cherkaoui El Moursli, R., Cheu, E., Cheung, K., Chevalier, L., Chiarella, V., Chiarelli, G., Chiodini, G., Chisholm, A. S., Chitan, A., Chiu, Y. H., Chizhov, M. V., Choi, K., Chomont, A. R., Chouridou, S., Chow, Y. S., Christodoulou, V., Chu, M. C., Chudoba, J., Chuinard, A. J., Chwastowski, J. J., Chytka, L., Ciftci, A. K., Cinca, D., Cindro, V., Cioară, I. A., Ciocio, A., Cirotto, F., Citron, Z. H., Citterio, M., Ciubancan, M., Clark, A., Clark, B. L., Clark, M. R., Clark, P. J., Clarke, R. N., Clement, C., Coadou, Y., Cobal, M., Coccaro, A., Cochran, J., Colasurdo, L., Cole, B., Colijn, A. P., Collot, J., Colombo, T., Conde Muiño, P., Coniavitis, E., Connell, S. H., Connelly, I. A., Constantinescu, S., Conti, G., Conventi, F., Cooke, M., Cooper-Sarkar, A. M., Cormier, F., Cormier, K. J. R., Corradi, M., Corriveau, F., Cortes-Gonzalez, A., Costa, G., Costa, M. J., Costanzo, D., Cottin, G., Cowan, G., Cox, B. E., Cranmer, K., Crawley, S. J., Creager, R. A., Cree, G., Crépé-Renaudin, S., Crescioli, F., Cribbs, W. A., Cristinziani, M., Croft, V., Crosetti, G., Cueto, A., Cuhadar Donszelmann, T., Cukierman, A. R., Cummings, J., Curatolo, M., Cúth, J., Czekierda, S., Czodrowski, P., D’amen, G., D’Auria, S., D’eramo, L., D’Onofrio, M., Da Cunha Sargedas De Sousa, M. J., Da Via, C., Dabrowski, W., Dado, T., Dai, T., Dale, O., Dallaire, F., Dallapiccola, C., Dam, M., Dandoy, J. R., Daneri, M. F., Dang, N. P., Daniells, A. C., Dann, N. S., Danninger, M., Dano Hoffmann, M., Dao, V., Darbo, G., Darmora, S., Dassoulas, J., Dattagupta, A., Daubney, T., Davey, W., David, C., Davidek, T., Davis, D. R., Davison, P., Dawe, E., Dawson, I., De, K., de Asmundis, R., De Benedetti, A., De Castro, S., De Cecco, S., De Groot, N., de Jong, P., De la Torre, H., De Lorenzi, F., De Maria, A., De Pedis, D., De Salvo, A., De Sanctis, U., De Santo, A., De Vasconcelos Corga, K., De Vivie De Regie, J. B., Debbe, R., Debenedetti, C., Dedovich, D. V., Dehghanian, N., Deigaard, I., Del Gaudio, M., Del Peso, J., Delgove, D., Deliot, F., Delitzsch, C. M., Dell’Acqua, A., Dell’Asta, L., Dell’Orso, M., Della Pietra, M., della Volpe, D., Delmastro, M., Delporte, C., Delsart, P. A., DeMarco, D. A., Demers, S., Demichev, M., Demilly, A., Denisov, S. P., Denysiuk, D., Derendarz, D., Derkaoui, J. E., Derue, F., Dervan, P., Desch, K., Deterre, C., Dette, K., Devesa, M. R., Deviveiros, P. O., Dewhurst, A., Dhaliwal, S., Di Bello, F. A., Di Ciaccio, A., Di Ciaccio, L., Di Clemente, W. K., Di Donato, C., Di Girolamo, A., Di Girolamo, B., Di Micco, B., Di Nardo, R., Di Petrillo, K. F., Di Simone, A., Di Sipio, R., Di Valentino, D., Diaconu, C., Diamond, M., Dias, F. A., Diaz, M. A., Dickinson, J., Diehl, E. B., Dietrich, J., Díez Cornell, S., Dimitrievska, A., Dingfelder, J., Dita, P., Dita, S., Dittus, F., Djama, F., Djobava, T., Djuvsland, J. I., do Vale, M. A. B., Dobos, D., Dobre, M., Dodsworth, D., Doglioni, C., Dolejsi, J., Dolezal, Z., Donadelli, M., Donati, S., Dondero, P., Donini, J., Dopke, J., Doria, A., Dova, M. T., Doyle, A. T., Drechsler, E., Dris, M., Du, Y., Duarte-Campderros, J., Dubinin, F., Dubreuil, A., Duchovni, E., Duckeck, G., Ducourthial, A., Ducu, O. A., Duda, D., Dudarev, A., Dudder, A. Chr., Duffield, E. M., Duflot, L., Dührssen, M., Dulsen, C., Dumancic, M., Dumitriu, A. E., Duncan, A. K., Dunford, M., Duperrin, A., Duran Yildiz, H., Düren, M., Durglishvili, A., Duschinger, D., Dutta, B., Duvnjak, D., Dyndal, M., Dziedzic, B. S., Eckardt, C., Ecker, K. M., Edgar, R. C., Eifert, T., Eigen, G., Einsweiler, K., Ekelof, T., El Kacimi, M., El Kosseifi, R., Ellajosyula, V., Ellert, M., Elles, S., Ellinghaus, F., Elliot, A. A., Ellis, N., Elmsheuser, J., Elsing, M., Emeliyanov, D., Enari, Y., Ennis, J. S., Epland, M. 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Y., Yusuff, I., Zabinski, B., Zacharis, G., Zaidan, R., Zaitsev, A. M., Zakharchuk, N., Zalieckas, J., Zaman, A., Zambito, S., Zanzi, D., Zeitnitz, C., Zemaityte, G., Zemla, A., Zeng, J. C., Zeng, Q., Zenin, O., Ženiš, T., Zerwas, D., Zhang, D., Zhang, D., Zhang, F., Zhang, G., Zhang, H., Zhang, J., Zhang, L., Zhang, L., Zhang, M., Zhang, P., Zhang, R., Zhang, R., Zhang, X., Zhang, Y., Zhang, Z., Zhao, X., Zhao, Y., Zhao, Z., Zhemchugov, A., Zhou, B., Zhou, C., Zhou, L., Zhou, M., Zhou, M., Zhou, N., Zhou, Y., Zhu, C. G., Zhu, H., Zhu, J., Zhu, Y., Zhuang, X., Zhukov, K., Zibell, A., Zieminska, D., Zimine, N. I., Zimmermann, C., Zimmermann, S., Zinonos, Z., Zinser, M., Ziolkowski, M., Živković, L., Zobernig, G., Zoccoli, A., Zou, R., zur Nedden, M., and Zwalinski, L.
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- 2023
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144. The role of the diaphragm in prediction of respiratory function in the immediate postoperative period in lung cancer patients using a machine learning model
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Vesovic, Radomir, Milosavljevic, Milan, Punt, Marija, Radomirovic, Jelica, Bascarevic, Slavisa, Savic, Milan, Milenkovic, Vladimir, Popovic, Marko, and Ercegovac, Maja
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- 2023
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145. Preadipocytes in human granulation tissue: role in wound healing and response to macrophage polarization
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Rauchenwald, Tina, Handle, Florian, Connolly, Catherine E., Degen, Antonia, Seifarth, Christof, Hermann, Martin, Tripp, Christoph H., Wilflingseder, Doris, Lobenwein, Susanne, Savic, Dragana, Pölzl, Leo, Morandi, Evi M., Wolfram, Dolores, Skvortsova, Ira-Ida, Stoitzner, Patrizia, Haybaeck, Johannes, Konschake, Marko, Pierer, Gerhard, and Ploner, Christian
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- 2023
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146. PAM-flexible genome editing with an engineered chimeric Cas9
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Zhao, Lin, Koseki, Sabrina R. T., Silverstein, Rachel A., Amrani, Nadia, Peng, Christina, Kramme, Christian, Savic, Natasha, Pacesa, Martin, Rodríguez, Tomás C., Stan, Teodora, Tysinger, Emma, Hong, Lauren, Yudistyra, Vivian, Ponnapati, Manvitha R., Jacobson, Joseph M., Church, George M., Jakimo, Noah, Truant, Ray, Jinek, Martin, Kleinstiver, Benjamin P., Sontheimer, Erik J., and Chatterjee, Pranam
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- 2023
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147. Piloting the integration of SMART Recovery into outpatient alcohol and other drug treatment programs
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Manning, V., Roxburgh, A. D., and Savic, M.
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- 2023
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148. Proposed linezolid dosing strategies to minimize adverse events for treatment of extensively drug-resistant tuberculosis
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Imperial, Marjorie Z, Nedelman, Jerry R, Conradie, Francesca, and Savic, Rada M
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Patient Safety ,Rare Diseases ,Neurosciences ,Tuberculosis ,Clinical Research ,Infectious Diseases ,Hematology ,Vaccine Related ,Peripheral Neuropathy ,Neurodegenerative ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Good Health and Well Being ,Adult ,Anemia ,Antitubercular Agents ,Extensively Drug-Resistant Tuberculosis ,Humans ,Linezolid ,Peripheral Nervous System Diseases ,Prospective Studies ,Thrombocytopenia ,Treatment Outcome ,Tuberculosis ,Multidrug-Resistant ,adverse events ,drug-resistant tuberculosis ,linezolid ,PK-PD modeling ,tuberculosis therapeutics ,PK–PD modeling ,Biological Sciences ,Medical and Health Sciences ,Microbiology - Abstract
BackgroundWe evaluated Nix-TB trial data (NCT02333799, N = 109) to provide dosing recommendations to potentially minimize linezolid toxicity in patients with extensively drug-resistant tuberculosis. .MethodsA pharmacokinetic model and toxicodynamic models for peripheral neuropathy, hemoglobin, and platelets were developed. Simulations compared safety outcomes for daily linezolid of 1200 and 600 mg, with and without dose adjustments for toxicity. Severe neuropathy was based on symptom scores from the Brief Peripheral Neuropathy Screen. Severe anemia and thrombocytopenia were defined as ≥ grade 3 adverse events according to the NIAID Division of Microbiology and Infectious Disease Adult Toxicity table.ResultsPredicted concentration-time profiles were a major predictor in all toxicodynamic models. Simulations showed higher percentages of patients with severe neuropathy (median, 19%; 90% confidence interval [CI], 17%-22% vs 5%, 4%-7%) and severe anemia (15%, 12%-17% vs 1%, 0%-2%) between 1200 and 600 mg daily linezolid. No differences in severe thrombocytopenia were observed (median, 10% decrease in hemoglobin level after 4 weeks of treatment would have maximum sensitivity (82%) and specificity (84%) for predicting severe anemia. Reducing the dose from 1200 to 600 mg triggered by this marker may prevent 60% (90% CI, 45%-72%) of severe anemia.ConclusionsSimple neuropathy symptom and hemoglobin monitoring may guide linezolid dosing to avoid toxicities, but prospective testing is needed to confirm the benefit-to-risk ratio.
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- 2022
149. Drug concentration at the site of disease in children with pulmonary tuberculosis
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Lopez-Varela, Elisa, Abulfathi, Ahmed A, Strydom, Natasha, Goussard, Pierre, van Wyk, Abraham C, Demers, Anne Marie, Van Deventer, Anneen, Garcia-Prats, Anthony J, van der Merwe, Johannes, Zimmerman, Matthew, Carter, Claire L, Janson, Jacques, Morrison, Julie, Reuter, Helmuth, Decloedt, Eric H, Seddon, James A, Svensson, Elin M, Warren, Rob, Savic, Radojka M, Dartois, Véronique, and Hesseling, Anneke C
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Patient Safety ,Clinical Research ,Orphan Drug ,Infectious Diseases ,HIV/AIDS ,Pediatric ,Tuberculosis ,Lung ,Rare Diseases ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Infection ,Good Health and Well Being ,Adult ,Antitubercular Agents ,Child ,Ethambutol ,Humans ,Infant ,Isoniazid ,Pyrazinamide ,South Africa ,Tuberculosis ,Pulmonary ,Microbiology ,Medical Microbiology ,Pharmacology and Pharmaceutical Sciences - Abstract
BackgroundCurrent TB treatment for children is not optimized to provide adequate drug levels in TB lesions. Dose optimization of first-line antituberculosis drugs to increase exposure at the site of disease could facilitate more optimal treatment and future treatment-shortening strategies across the disease spectrum in children with pulmonary TB.ObjectivesTo determine the concentrations of first-line antituberculosis drugs at the site of disease in children with intrathoracic TB.MethodsWe quantified drug concentrations in tissue samples from 13 children, median age 8.6 months, with complicated forms of pulmonary TB requiring bronchoscopy or transthoracic surgical lymph node decompression in a tertiary hospital in Cape Town, South Africa. Pharmacokinetic models were used to describe drug penetration characteristics and to simulate concentration profiles for bronchoalveolar lavage, homogenized lymph nodes, and cellular and necrotic lymph node lesions.ResultsIsoniazid, rifampicin and pyrazinamide showed lower penetration in most lymph node areas compared with plasma, while ethambutol accumulated in tissue. None of the drugs studied was able to reach target concentration in necrotic lesions.ConclusionsDespite similar penetration characteristics compared with adults, low plasma exposures in children led to low site of disease exposures for all drugs except for isoniazid.
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- 2022
150. Pharmacokinetics and Safety of 3 Months of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention in Pregnant Women
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Mathad, Jyoti S, Savic, Rada, Britto, Paula, Jayachandran, Priya, Wiesner, Lubbe, Montepiedra, Grace, Norman, Jennifer, Zhang, Nan, Townley, Ellen, Chakhtoura, Nahida, Bradford, Sarah, Patil, Sandesh, Popson, Stephanie, Chipato, Tsungai, Rouzier, Vanessa, Langat, Deborah, Chalermchockcharoentkit, Amphan, Kamthunzi, Portia, Gupta, Amita, and Dooley, Kelly E
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Reproductive Medicine ,Biomedical and Clinical Sciences ,HIV/AIDS ,Clinical Trials and Supportive Activities ,Clinical Research ,Pediatric ,Rare Diseases ,Prevention ,Infectious Diseases ,Tuberculosis ,Emerging Infectious Diseases ,Patient Safety ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Infection ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,Antitubercular Agents ,Child ,Drug Therapy ,Combination ,Female ,HIV Infections ,Humans ,Isoniazid ,Latent Tuberculosis ,Male ,Pregnancy ,Pregnant Women ,Rifampin ,maternal health ,latent tuberculosis ,rifapentine ,pharmacokinetics ,HIV ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Clinical sciences - Abstract
BackgroundPregnancy increases the risk of tuberculosis and its complications. A 3-month regimen of weekly isoniazid and rifapentine (3HP) is safe and effective for tuberculosis prevention in adults and children, including those with HIV, but 3HP has not been evaluated in pregnancy.MethodsIMPAACT 2001 was a phase I/II trial evaluating the pharmacokinetics and safety of 3HP among pregnant women with indications for tuberculosis preventative therapy in Haiti, Kenya, Malawi, Thailand, and Zimbabwe (NCT02651259). Isoniazid and rifapentine were provided at standard doses (900 mg/week). Pharmacokinetic sampling was performed with the first (second/third trimester) and twelfth (third trimester/postpartum) doses. Nonlinear mixed-effects models were used to estimate drug population pharmacokinetics.ResultsOf 50 participants, 20 had HIV and were taking efavirenz-based antiretroviral therapy. Among women without HIV, clearance of rifapentine was 28% lower during pregnancy than postpartum (1.20 vs 1.53 L/hour, P
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- 2022
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