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101. Additional file 4 of Clinical effects of a selective urate reabsorption inhibitor dotinurad in patients with hyperuricemia and treated hypertension: a multicenter, prospective, exploratory study (DIANA)

Author

Tanaka, Atsushi, Taguchi, Isao, Hisauchi, Itaru, Yoshida, Hisako, Shimabukuro, Michio, Hongo, Hiroshi, Ishikawa, Tetsuya, Kadokami, Toshiaki, Yagi, Shusuke, Sata, Masataka, and Node, Koichi

Abstract

Additional file 4: Table S3. Odds ratios for achieving an SUA level of ≤ 6.0 mg/dL according to baseline SUA levels.

Published
2023
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102. Additional file 2 of Clinical effects of a selective urate reabsorption inhibitor dotinurad in patients with hyperuricemia and treated hypertension: a multicenter, prospective, exploratory study (DIANA)

Author

Tanaka, Atsushi, Taguchi, Isao, Hisauchi, Itaru, Yoshida, Hisako, Shimabukuro, Michio, Hongo, Hiroshi, Ishikawa, Tetsuya, Kadokami, Toshiaki, Yagi, Shusuke, Sata, Masataka, and Node, Koichi

Abstract

Additional file 2: Fig. S1. Doses of dotinurad at each visit.

Published
2023
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103. Additional file 1 of Clinical effects of a selective urate reabsorption inhibitor dotinurad in patients with hyperuricemia and treated hypertension: a multicenter, prospective, exploratory study (DIANA)

Author

Tanaka, Atsushi, Taguchi, Isao, Hisauchi, Itaru, Yoshida, Hisako, Shimabukuro, Michio, Hongo, Hiroshi, Ishikawa, Tetsuya, Kadokami, Toshiaki, Yagi, Shusuke, Sata, Masataka, and Node, Koichi

Abstract

Additional file 1: Table S1. Eligibility criteria for the DIANA study.

Published
2023
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105. 心収縮予備能に対する心房細動カテーテルアブレーションの効果 : 下肢陽圧負荷心エコー図法を用いた検討

Author

Ishii, Nao, Kusunose, Kenya, Shono, Ayu, Matsumoto, Kensuke, Nishio, Susumu, Yamaguchi, Natsumi, Hirata, Yukina, Matsuura, Tomomi, Ise, Takayuki, Yamaguchi, Koji, Yagi, Shusuke, Fukuda, Daiju, Yamada, Hirotsugu, Soeki, Takeshi, Wakatsuki, Tetsuzo, and Sata, Masataka

Subjects
Cardiac Reserve, Echocardiography, atrial fibrillation, left atrial function, Preload Stress
Abstract

The effects of catheter ablation on exercise tolerance and quality of life in patients with atrial fibrillation (AF) have been reported. We assessed cardiac function in more detail using the leg positive pressure (LPP) technique and found that contractile reserve is particularly important in relation to exercise tolerance and prognosis. In this study, we used the LPP technique to examine changes in contractile reserve immediately after ablation and 6 months later. We prospectively enrolled patients who underwent catheter ablation for AF at 2 institutes. We performed LPP stress echocardiography 2 to 3 days after (FU-1) and 6 months after (FU-2) ablation to examine changes in cardiac function indexes. The primary end point was improvement in contractile reserve. Ultimately, 109 patients (mean age 67.4 ± 9.6 years; 70% men) underwent 2 sessions of LPP stress echocardiography. The median CHA2DS2-VASC score was 2 (interquartile range 13). From FU-1 to FU-2, the change in the stroke volume index after the LPP maneuver increased in patients with paroxysmal and persistent AF with low CHA2DS2-VASC scores (both p

Published
2022

106. Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese

Author

Tomiyama, Hirofumi, Kohro, Takahide, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Watanabe, Kentaro, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Ikeda, Hisao, and Yamashina, Akira

Published
2015
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110. Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study

Author

Kajikawa, Masato, Maruhashi, Tatsuya, Hidaka, Takayuki, Matsui, Shogo, Hashimoto, Haruki, Takaeko, Yuji, Nakano, Yukiko, Kurisu, Satoshi, Kihara, Yasuki, Yusoff, Farina Mohamad, Kishimoto, Shinji, Chayama, Kazuaki, Goto, Chikara, Noma, Kensuke, Nakashima, Ayumu, Hiro, Takafumi, Hirayama, Atsushi, Shiina, Kazuki, Tomiyama, Hirofumi, Yagi, Shusuke, Amano, Rie, Yamada, Hirotsugu, Sata, Masataka, and Higashi, Yukihito

Published
2019
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111. Factors associated with carotid intima-media thickness progression in patients with asymptomatic hyperuricemia: insights from the PRIZE study.

Author

Saito, Yuichi, Tanaka, Atsushi, Ishizu, Tomoko, Yoshida, Hisako, Kubota, Yoshiaki, Nanasato, Mamoru, Matsuhisa, Munehide, Ohya, Yusuke, Kobayashi, Yoshio, Node, Koichi, Murohara, Toyoaki, Inoue, Teruo, Sata, Masataka, Ohishi, Mitsuru, Yokote, Kotaro, Kario, Kazuomi, Watada, Hirotaka, Shimomura, Iichiro, Fukumoto, Yoshihiro, and Maemura, Koji

Subjects
CAROTID intima-media thickness, ASYMPTOMATIC patients, CAROTID artery ultrasonography, HYPERURICEMIA, BODY mass index, CAROTID artery, MULTIVARIABLE testing, PROGRESSION-free survival
Abstract

Hyperuricemia is reportedly associated with the progression of carotid intima-media thickness (IMT), a surrogate of cardiovascular risks and events. However, factors associated with carotid IMT progression in patients with asymptomatic hyperuricemia are largely unknown. In this post-hoc analysis of the multicenter, randomized PRIZE study, we analyzed data from a total of 326 patients who underwent carotid ultrasonography in a blind manner at baseline and 24 months to evaluate carotid IMT. Mean and maximum IMT at the common carotid artery (CCA) were measured at a central core laboratory. Factors related to the absolute change in mean and maximum IMT from baseline to 24 months were explored. Overall, the adjusted mean [0.0032 (− 0.0214 to 0.0278) mm] and maximum [0.0011 (− 0.0327 to 0.0351) mm] CCA-IMT increased numerically from baseline to 24 months. Multivariable analysis identified higher body mass index, history of atherosclerotic cardiovascular disease (ASCVD), and lower mean CCA-IMT at baseline as significant factors associated with the increase in mean CCA-IMT. In addition, older age and lower mean CCA-IMT at baseline were significant factors for an increased absolute change in the maximum CCA-IMT at 24 months. The present sub-analysis of the PRIZE study showed higher body mass index, history of ASCVD, and older age as significant factors associated with CCA-IMT progression in patients with asymptomatic hyperuricemia. These factors may be considered when identifying the possible risk of atherosclerotic progression in this specific patient population of hyperuricemia. Trial registration: UMIN000012911 and UMIN000041322. [ABSTRACT FROM AUTHOR]

Published
2023
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117. Isoproterenol loading transesophageal echocardiography in atrial fibrillation

Author

Takahashi, Tomonori, primary, Kusunose, Kenya, additional, Hayashi, Shuji, additional, Zheng, Robert, additional, Yamaguchi, Natsumi, additional, Morita, Sae, additional, Hirata, Yukina, additional, Nishio, Susumu, additional, Saijo, Yoshihito, additional, Ise, Takayuki, additional, Yamaguchi, Koji, additional, Yagi, Shusuke, additional, Yamada, Hirotsugu, additional, Soeki, Takeshi, additional, Wakatsuki, Tetsuzo, additional, and Sata, Masataka, additional

Published
2022
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118. Features and Outcomes of Histologically Proven Myocarditis With Fulminant Presentation

Author

Kanaoka, Koshiro, primary, Onoue, Kenji, additional, Terasaki, Satoshi, additional, Nakano, Tomoya, additional, Nakai, Michikazu, additional, Sumita, Yoko, additional, Hatakeyama, Kinta, additional, Terasaki, Fumio, additional, Kawakami, Rika, additional, Iwanaga, Yoshitaka, additional, Miyamoto, Yoshihiro, additional, Saito, Yoshihiko, additional, Yuda, Satoshi, additional, Tanno, Masaya, additional, Takahashi, Toru, additional, Yokoshiki, Hisashi, additional, Toba, Masahiro, additional, Anzai, Toshihisa, additional, Nagai, Toshiyuki, additional, Sato, Takuma, additional, Takenaka, Takashi, additional, Yamazaki, Seiji, additional, Katagiri, Yuki, additional, Takeuchi, Toshiharu, additional, Sugitatsu, Kazuya, additional, Kakinoki, Shigeo, additional, Matsumoto, Tomoaki, additional, Urasawa, Kazushi, additional, Tan, Michinao, additional, Tsujino, Ichizo, additional, Kamigaki, Mitsunori, additional, Tomita, Hirofumi, additional, Hanada, Kenji, additional, Kushibiki, Motoi, additional, Nakamura, Akihiro, additional, Morino, Yoshihiro, additional, Nasu, Takahito, additional, Yasuda, Satoshi, additional, Suzuki, Hideaki, additional, Iwabuchi, Kaoru, additional, Tsuji, Kanako, additional, Namiuchi, Shigeto, additional, Komaru, Tatsuya, additional, Yagi, Masahiro, additional, Uematsu, Shoko, additional, Takahashi, Toshiaki, additional, Takeda, Satoru, additional, Nakanishi, Toru, additional, Watanabe, Masafumi, additional, Wanezaki, Masahiro, additional, Matsui, Motoyuki, additional, Sugawara, Shigeo, additional, Takeishi, Yasuchika, additional, Oikawa, Masayoshi, additional, Komatsu, Nobuo, additional, Suzuki, Satoshi, additional, Okamoto, Hiroshi, additional, Takeyasu, Noriyuki, additional, Akiyama, Daiki, additional, Eki, Yutaka, additional, Kakuta, Tsunekazu, additional, Sugiyama, Tomoyo, additional, Koizumi, Tomomi, additional, Ueno, Koji, additional, Kario, Kazuomi, additional, Taki, Mizuri, additional, Matsumoto, Yuri, additional, Yasu, Takanori, additional, Nishioka, Osamu, additional, Naito, Shigeto, additional, Murata, Makoto, additional, Tange, Shoichi, additional, Kaneko, Katsumi, additional, Muto, Makoto, additional, Inagaki, Hiroshi, additional, Hasegawa, Shuichi, additional, Tachibana, Eizo, additional, Atsumi, Wataru, additional, Suzuki, Masahiro, additional, Muramatsu, Toshihiro, additional, Yamada, Yoshihiro, additional, Taguchi, Isao, additional, Fukuda, Yoshiaki, additional, Matsui, Akihiro, additional, Kanda, Junji, additional, Hozawa, Koji, additional, Matsumura, Akihiko, additional, Shimizu, Wataru, additional, Yamamoto, Takeshi, additional, Komuro, Issei, additional, Hatano, Masaru, additional, Ikeda, Takanori, additional, Kiuchi, Shunsuke, additional, Chikamori, Taishiro, additional, Takei, Yasuyoshi, additional, Soejima, Kyoko, additional, Minamishima, Toshinori, additional, Tanaka, Hiroyuki, additional, Shimizu, Shigeo, additional, Kasao, Masashi, additional, Kadohira, Tadayuki, additional, Minamino, Tohru, additional, Shimada, Kazunori, additional, Iwata, Hiroshi, additional, Momiyama, Yukihiko, additional, Ashikaga, Takashi, additional, Nozato, Toshihiro, additional, Fujiwara, Yasumasa, additional, Inoue, Kenji, additional, Sasano, Tetsuo, additional, Matsuda, Junji, additional, Ishii, Yasuhiro, additional, Ono, Yuichi, additional, Tanabe, Kengo, additional, Horiuchi, Yu, additional, Shinke, Toshiro, additional, Kodama, Yusuke, additional, Moroi, Masao, additional, Yazaki, Yoshiyuki, additional, Mizumura, Taisuke, additional, Ohta, Hiroshi, additional, Akashi, Yoshihiro, additional, Kotoku, Nozomi, additional, Ikari, Yuji, additional, Maruyama, Mitsunori, additional, Sato, Yasuhiro, additional, Tamura, Koichi, additional, Konishi, Masaaki, additional, Suzuki, Hiroshi, additional, Ebato, Mio, additional, Fukui, Kazuki, additional, Yumoto, Kazuhiko, additional, Iwasawa, Takamasa, additional, Kashimura, Takeshi, additional, Takahashi, Kazuyoshi, additional, Okada, Yoshinobu, additional, Kaku, Bunji, additional, Usuda, Kazuo, additional, Maruyama, Michiro, additional, Kameyama, Tomoki, additional, Higashikata, Toshinori, additional, Hodatsu, Akihiko, additional, Osato, Kazuo, additional, Nagata, Yoji, additional, Maeno, Koji, additional, Satake, Kazuo, additional, Sawanobori, Takao, additional, Watanabe, Noboru, additional, Kuwahara, Koichiro, additional, Motoki, Hirohiko, additional, Kitabayashi, Hiroshi, additional, Otagiri, Kyuhachi, additional, Kono, Tsunesuke, additional, Yamagishi, Daisuke, additional, Yazaki, Yoshikazu, additional, Noda, Toshiyuki, additional, Morishima, Itsuro, additional, Watanabe, Naoki, additional, Tanaka, Shinichiro, additional, Onodera, Tomoya, additional, Nawada, Ryuzo, additional, Watanabe, Akinori, additional, Matsunaga, Masaki, additional, Suwa, Satoru, additional, Sakamoto, Hiroshi, additional, Sakamoto, Hiroki, additional, Aoyama, Takeshi, additional, Kanamori, Norio, additional, Muto, Masahiro, additional, Maekawa, Yuichiro, additional, Ohtani, Hayato, additional, Ozaki, Yukio, additional, Naruse, Kenshin, additional, Takemoto, Kenji, additional, Kamiya, Haruo, additional, Suzuki, Takeshi, additional, Tomita, Yasushi, additional, Suzuki, Susumu, additional, Kametani, Ryosuke, additional, Aoyama, Hidekazu, additional, Osanai, Hiroyuki, additional, Harada, Ken, additional, Kada, Kenji, additional, Saeki, Tomoaki, additional, Kobayashi, Koichi, additional, Ogawa, Yasuhiro, additional, Terasawa, Akihiro, additional, Shinoda, Masanori, additional, Oguri, Mitsutoshi, additional, Shimizu, Kiyokazu, additional, Sawamura, Akinori, additional, Sugiura, Atsushi, additional, Hattori, Kosuke, additional, Mokuno, Shinji, additional, Kondo, Kazuhisa, additional, Dohi, Kaoru, additional, Moriwaki, Keishi, additional, Kasai, Atsunobu, additional, Nakakuki, Tetsuya, additional, Kaitani, Kazuaki, additional, Jinnai, Toshikazu, additional, Yamamoto, Takashi, additional, Kurata, Hiroyuki, additional, Wada, Atsuyuki, additional, Akao, Masaharu, additional, Hamatani, Yasuhiro, additional, Ishibashi, Kazuya, additional, Akakabe, Yoshiki, additional, Asaumi, Yasuhide, additional, Matama, Hideo, additional, Sakata, Yasushi, additional, Kioka, Hidetaka, additional, Takaishi, Hiroshi, additional, Takase, Toru, additional, Matsuda, Mitsuo, additional, Sato, Fumi, additional, Hasegawa, Shinji, additional, Ishigami, Kenichi, additional, Ichikawa, Minoru, additional, Takagi, Takashi, additional, Inoko, Moriaki, additional, Hoshiga, Masaaki, additional, Fujita, Shuichi, additional, Takeda, Yoshihiro, additional, Kawarabayashi, Takahiko, additional, Takaoka, Hideyuki, additional, Nakajima, Kenji, additional, Yuguchi, Tadashi, additional, Kawasaki, Tatsuya, additional, Shinoda, Yukinori, additional, Sato, Yukihito, additional, Ishihara, Masaharu, additional, Matsumoto, Yuki, additional, Kawai, Hiroya, additional, Takaya, Tomofumi, additional, Matsuo, Kouki, additional, Mano, Toshiaki, additional, Hirata, Kenichi, additional, Hisamatsu, Eriko, additional, Inoue, Nobutaka, additional, Tamita, Koichi, additional, Mukohara, Naoki, additional, Shimoyama, Hisashi, additional, Miyajima, Toru, additional, Tamura, Toshihiro, additional, Tamaki, Yodo, additional, Suzuki, Megumi, additional, Yokota, Ryoji, additional, Horii, Manabu, additional, Yamanaka, Kazuo, additional, Kawata, Hiroyuki, additional, Hashimoto, Yukihiro, additional, Nakada, Yasuki, additional, Nakagawa, Hitoshi, additional, Ueda, Tomoya, additional, Nishida, Taku, additional, Seno, Ayako, additional, Watanabe, Makoto, additional, Akasaka, Takashi, additional, Tanimoto, Takashi, additional, Toyofuku, Mamoru, additional, Yamamoto, Kazuhiro, additional, Kinugasa, Yoshiharu, additional, Hirai, Masayuki, additional, Nasu, Hiroshi, additional, Shirota, Kinya, additional, Oda, Tsuyoshi, additional, Oka, Takefumi, additional, Kadota, Kazushige, additional, Ohya, Masanobu, additional, Ito, Hiroshi, additional, Nakamura, Kazufumi, additional, Ogura, Soichiro, additional, Fuke, Soichiro, additional, Uemura, Shiro, additional, Matsubara, Hiromi, additional, Watanabe, Atsuyuki, additional, Morishima, Nobuyuki, additional, Kihara, Yasuki, additional, Hidaka, Takayuki, additional, Ueda, Hironori, additional, Ono, Yujiro, additional, Muraoka, Yuji, additional, Hatanari, Miyo, additional, Miyamoto, Yoshinori, additional, Dote, Keigo, additional, Kato, Masaya, additional, Yano, Masafumi, additional, Mochizuki, Mamoru, additional, Ikeda, Yasuhiro, additional, Fujinaga, Hiroyuki, additional, Hosokawa, Shinobu, additional, Sata, Masataka, additional, Yamaguchi, Koji, additional, Aki, Naoko, additional, Minamino, Tetsuo, additional, Miyake, Yuichi, additional, Takagi, Yuichiro, additional, Doi, Masayuki, additional, Taketani, Yoshio, additional, Okayama, Hideki, additional, Shigematsu, Tatsuya, additional, Higaki, Akinori, additional, Yamaguchi, Osamu, additional, Inaba, Shinji, additional, Ikeda, Shuntaro, additional, Kawai, Kazuya, additional, Kitaoka, Hiroaki, additional, Kubo, Toru, additional, Ando, Kenji, additional, Inui, Kaoru, additional, Fukumoto, Yoshihiro, additional, Hori, Kensuke, additional, Homma, Takehiro, additional, Kawasaki, Tomohiro, additional, Mohri, Masahiro, additional, Fujiwara, Masaki, additional, Tsutsui, Hiroyuki, additional, Ide, Tomomi, additional, Miura, Shin-Ichiro, additional, Kuwano, Takashi, additional, Shimomura, Hideki, additional, Kadokami, Toshiaki, additional, Taba, Masanao, additional, Kondou, Katsuhiro, additional, Kubota, Toru, additional, Nagatomo, Daisuke, additional, Mukai, Yasushi, additional, Matsukawa, Ryuichi, additional, Tashiro, Hideki, additional, Shimomura, Mitsuhiro, additional, Maemura, Koji, additional, Kawano, Hiroaki, additional, Oku, Koji, additional, Yamasa, Toshihiko, additional, Kizaki, Yoshihisa, additional, Sakamoto, Tomohiro, additional, Tamura, Yudai, additional, Ito, Teruhiko, additional, Fujimoto, Kazuteru, additional, Tsujita, Kenichi, additional, Takashio, Seiji, additional, Kurokawa, Hirofumi, additional, Takahashi, Naohiko, additional, Saito, Shotaro, additional, Arikawa, Masaya, additional, Shibata, Yoshisato, additional, Nishihira, Kensaku, additional, Tsuruda, Toshihiro, additional, Sonoda, Masahiro, additional, Atsuchi, Nobuhiko, additional, Ohishi, Mitsuru, additional, Higuchi, Koji, additional, Miyata, Masaaki, additional, Oketani, Naoya, additional, Akimoto, Yoshinori, additional, Asahi, Tomohiro, additional, and Wake, Minoru, additional

Published
2022
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119. 新規選択的ペルオキシソーム増殖剤活性化受容体αモジュレーターであるペマフィブラートは血漿エイコサノイドを減少させ、糖尿病マウスの血管内皮機能障害を改善する

Author

Suto, Kumiko, Fukuda, Daiju, Shinohara, Masakazu, Ganbaatar, Byambasuren, Yagi, Shusuke, Kusunose, Kenya, Yamada, Hirotsugu, Soeki, Takeshi, Hirata, Ken-ichi, and Sata, Masataka

Subjects
Pemafibrate, Diabetes, Endothelial function, Eicosanoid
Abstract

Aims: Various pathological processes related to diabetes cause endothelial dysfunction. Eicosanoids derived from arachidonic acid (AA) have roles in vascular regulation. Fibrates have recently been shown to attenuate vascular complications in diabetics. Here we examined the effects of pemafibrate, a selective peroxisome proliferator-activated receptor α modulator, on plasma eicosanoid levels and endothelial function in diabetic mice. Methods: Diabetes was induced in 7-week-old male wild-type mice by a single injection of streptozotocin (150 mg/kg). Pemafibrate (0.3 mg/kg/day) was administered orally for 3 weeks. Untreated mice received vehicle. Circulating levels of eicosanoids and free fatty acids were measured using both gas and liquid chromatography-mass spectrometry. Endothelium-dependent and endothelium-independent vascular responses to acetylcholine and sodium nitroprusside, respectively, were analyzed. Results: Pemafibrate reduced both triglyceride and non-high-density lipoprotein-cholesterol levels (P＜0.01), without affecting body weight. It also decreased circulating levels of AA (P＜0.001), thromboxane B2 (P＜0.001), prostaglandin E2, leukotriene B4 (P＜0.05), and 5 hydroxyeicosatetraenoic acid (P＜0.001), all of which were elevated by the induction of diabetes. In contrast, the plasma levels of 15-deoxy-Δ12,14-prostaglandin J2, which declined following diabetes induction, remained unaffected by pemafibrate treatment. In diabetic mice, pemafibrate decreased palmitic acid (PA) and stearic acid concentrations (P＜0.05). Diabetes induction impaired endothelial function, whereas pemafibrate ameliorated it (P＜0.001). The results of ex vivo experiments indicated that eicosanoids or PA impaired endothelial function. Conclusion: Pemafibrate diminished the levels of vasoconstrictive eicosanoids and free fatty acids accompanied by a reduction of triglyceride. These effects may be associated with the improvement of endothelial function by pemafibrate in diabetic mice.

Published
2021

120. The Utility of a Combination of 99mTc-MIBI Washout Imaging and Cardiac Magnetic Resonance Imaging in the Evaluation of Cardiomyopathy

Author

Yamanaka, Moriaki, Takao, Shoichiro, Otsuka, Hideki, Otomi, Yoichi, Irahara, Saho, Kunikane, Yamato, Takashi, Satoru, Yamamoto, Airi, Sata, Masataka, and Harada, Masafumi

Subjects
99mTc-MIBI, Cardiomyopathy, cardiovascular diseases, Late gadolinium enhancement (LGE), Washout
Abstract

Background: In cardiomyopathy, 99mTc-MIBI washout can reflect mitochondrial dysfunction and late gadolinium enhancement (LGE) on cardiac magnetic imaging (MRI) is associated with tissue fibrosis. We sought to determine the relationship between 99mTc-MIBI uptake, 99mTc-MIBI washout, and LGE on MRI in patients with cardiomyopathy. Methods: Twenty-one patients underwent rest myocardial perfusion scintigraphy at 45 minutes (early) and 4 hours (delayed) after intravenous 99mTc-MIBI administration and cardiac MRI. We assessed myocardial perfusion, 99mTc-MIBI washout, and LGE. We divided the left ventricle (LV) wall into 16 segments using a polar map. Then, we classified each segment into 5 groups according to 99mTc-MIBI uptake in early-rest images and washout. Additionally, we created a contingency table based on LGE presence/absence in the groups. Results: We evaluated 336 segments in 21 patients. 99mTc-MIBI uptake was decreased in 168 segments in the early-rest 99mTc-MIBI images. 99mTc-MIBI washout was observed in 108 segments with either normal perfusion or reduced perfusion in the early-rest 99mTc-MIBI images. LGE was positive in 104 segments. A contingency table analysis with Fisher’s exact test showed that LGE was observed significantly more frequently in the segments with decreased 99mTc-MIBI uptake (p < 0.001). In segments without a decreased 99mTc-MIBI uptake, there was a significant correlation between increased 99mTc-MIBI washout and the presence of LGE (p = 0.033). Conclusions: In cardiomyopathy, the mitochondrial dysfunction in the early stage is shown as 99mTc-MIBI washout, and fibrotic changes in the myocardium in advanced stages are shown as LGE on cardiac MRI. The severity of myocardial damage and the clinical stage of cardiomyopathy can be evaluated using multimodal imaging.

Published
2021

121. Role of Protease-Activated Receptor 2 in AF

Author

Matsuura, Tomomi, Soeki, Takeshi, Fukuda, Daiju, Uematsu, Etsuko, Tobiume, Takeshi, Hara, Tomoya, Kusunose, Kenya, Ise, Takayuki, Yamaguchi, Koji, Yagi, Shusuke, Yamada, Hirotsugu, Wakatsuki, Tetsuzo, and Sata, Masataka

Subjects
anticoagulants, FXa, inflammation, cardiovascular system, atrial fibrillation, cardiovascular diseases, PAR2
Abstract

Background: Activated factor X (FXa), which contributes to chronic inflammation via protease-activated receptor 2 (PAR2), might play an important role in atrial fibrillation (AF) arrhythmogenesis. This study aimed to assess whether PAR2 signaling contributes to AF arrhythmogenesis and whether rivaroxaban ameliorates atrial inflammation and prevents AF. Methods and Results: In Study 1, PAR2 deficient (PAR2−/−) and wild-type mice were infused with angiotensin II (Ang II) or a vehicle via an osmotic minipump for 2 weeks. In Study 2, spontaneously hypertensive rats (SHRs) were treated with rivaroxaban, warfarin, or vehicle for 2 weeks after 8h of right atrial rapid pacing. The AF inducibility and atrial remodeling in both studies were examined. Ang II-treated PAR2−/− mice had a lower incidence of AF and less mRNA expression of collagen1 and collagen3 in the atrium compared to wild-type mice treated with Ang II. Rivaroxaban significantly reduced AF inducibility compared with warfarin or vehicle. In SHRs treated with a vehicle, rapid atrial pacing promoted gene expression of inflammatory and fibrosis-related biomarkers in the atrium. Rivaroxaban, but not warfarin, significantly reduced expression levels of these genes. Conclusions: The FXa–PAR2 signaling pathway might contribute to AF arrhythmogenesis associated with atrial inflammation. A direct FXa inhibitor, rivaroxaban, could prevent atrial inflammation and reduce AF inducibility, probably by inhibiting the pro-inflammatory activation.

Published
2021

122. 3Dマッピングシステムを用いた両心房Stimulus-V mapによる順行性速伝導路入口部の解剖学的位置並び特徴の検討

Author

Matsumoto, Kazuhisa, Tobiume, Takeshi, Matsuura, Tomomi, Ise, Takayuki, Kusunose, Kenya, Yamaguchi, Koji, Yagi, Shusuke, Fukuda, Daijyu, Wakatsuki, Tetsuzo, Yamada, Hirotsugu, Soeki, Takeshi, and Sata, Masataka

Subjects
antegrade fast pathway, St-V map, St-H map, Right atrial input, Left atrial input
Abstract

Purpose Previous studies examined the right atrial (RA) input site of the antegrade fast pathway (AFp) (AFpI). However, the left atrial (LA) input to the atrioventricular (AV) node has not been extensively evaluated. In this study, we created three-dimensional (3-D) bi-atrial stimulus-ventricle (St-V) maps and analyzed the input site and characteristics of the AFp in both the RA and LA. Methods Forty-four patients diagnosed with atrial fibrillation or WPW syndrome were included in this study. Three-dimensional bi-atrial St-V mapping was performed using an electroanatomical mapping system. Sites exhibiting the minimal St-V interval (MinSt-V) were defined as AFpIs and were classified into seven segments, four in the RA (F, S, M, and I) and three in the LA (M1, M2, and M3). By combining the MinSt-V in the RA and LA, the AFpIs were classified into three types: RA, LA, and bi-atrial (BA) types. The clinical and electrophysiological characteristics were compared. Results AFpIs were most frequently observed at site S in the RA (34%) and M2 in the LA (50%), and the BA type was the most common (57%). AFpIs in the LA were recognized in 75% of the patients. There were no clinical or electrophysiological indicators for predicting AFpI sites. Conclusions Three-dimensional bi-atrial St-V maps could classify AFpIs in both the RA and LA. AFpIs in the LA were frequently recognized. There were no significant clinical or electrophysiological indicators for predicting AFpI sites, and 3-D bi-atrial St-V mapping was the only method to reveal the precise AFp input site.

Published
2021

123. Expanding role of deoxyribonucleic acid-sensing mechanism in the development of lifestyle-related diseases

Author

Nishimoto, Sachiko, Sata, Masataka, and Fukuda, Daiju

Subjects
Cardiology and Cardiovascular Medicine
Abstract

In lifestyle-related diseases, such as cardiovascular, metabolic, respiratory, and kidney diseases, chronic inflammation plays a causal role in their pathogenesis; however, underlying mechanisms of sterile chronic inflammation are not well-understood. Previous studies have confirmed the damage of cells in these organs in the presence of various risk factors such as diabetes, dyslipidemia, and cigarette smoking, releasing various endogenous ligands for pattern recognition receptors. These studies suggested that nucleic acids released from damaged tissues accumulate in these tissues, acting as an endogenous ligand. Undamaged DNA is an integral factor for the sustenance of life, whereas, DNA fragments, especially those from pathogens, are potent activators of the inflammatory response. Recent studies have indicated that inflammatory responses such as the production of type I interferon (IFN) induced by DNA-sensing mechanisms which contributes to self-defense system in innate immunity participates in the progression of inflammatory diseases by the recognition of nucleic acids derived from the host, including mitochondrial DNA (mtDNA). The body possesses several types of DNA sensors. Toll-like receptor 9 (TLR9) recognizes DNA fragments in the endosomes. In addition, the binding of DNA fragments in the cytosol activates cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS), resulting in the synthesis of the second messenger cyclic GMP-AMP (cGAMP). The binding of cGAMP to stimulator of interferon genes (STING) activates NF-κB and TBK-1 signaling and consequently the production of many inflammatory cytokines including IFNs. Numerous previous studies have demonstrated the role of DNA sensors in self-defense through the recognition of DNA fragments derived from pathogens. Beyond the canonical role of TLR9 and cGAS-STING, this review describes the role of these DNA-sensing mechanism in the inflammatory responses caused by endogenous DNA fragments, and in the pathogenesis of lifestyle-related diseases.

Published
2022

124. Esaxerenone, a selective mineralocorticoid receptor blocker, improves insulin sensitivity in mice consuming high-fat diet

Author

Bavuu, Oyunbileg, primary, Fukuda, Daiju, additional, Ganbaatar, Byambasuren, additional, Matsuura, Tomomi, additional, Ise, Takayuki, additional, Kusunose, Kenya, additional, Yamaguchi, Koji, additional, Yagi, Shusuke, additional, Yamada, Hirotsugu, additional, Soeki, Takeshi, additional, Wakatsuki, Tetsuzo, additional, and Sata, Masataka, additional

Published
2022
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125. Clinical course and decision‐making in heart failure by preload stress echocardiography: a preliminary study

Author

Kusunose, Kenya, primary, Yamada, Hirotsugu, additional, Saijo, Yoshihito, additional, Nishio, Susumu, additional, Hirata, Yukina, additional, Ise, Takayuki, additional, Yamaguchi, Koji, additional, Fukuda, Daiju, additional, Yagi, Shusuke, additional, Soeki, Takeshi, additional, Wakatsuki, Tetsuzo, additional, and Sata, Masataka, additional

Published
2022
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126. Effect of Novel Stratified Lipid Risk by “LDL-Window” and Flow-Mediated Dilation on the Prognosis of Coronary Artery Disease Using the FMD-J Study A Data

Author

Abe, Shichiro, primary, Haruyama, Yasuo, additional, Kobashi, Gen, additional, Toyoda, Shigeru, additional, Inoue, Teruo, additional, Tomiyama, Hirofumi, additional, Ishizu, Tomoko, additional, Kohro, Takahide, additional, Higashi, Yukihito, additional, Takase, Bonpei, additional, Suzuki, Toru, additional, Ueda, Shinichiro, additional, Yamazaki, Tsutomu, additional, Furumoto, Tomoo, additional, Kario, Kazuomi, additional, Koba, Shinji, additional, Takemoto, Yasuhiko, additional, Hano, Takuzo, additional, Sata, Masataka, additional, Ishibashi, Yutaka, additional, Node, Koichi, additional, Maemura, Koji, additional, Ohya, Yusuke, additional, Furukawa, Taiji, additional, Ito, Hiroshi, additional, and Yamashina, Akira, additional

Published
2022
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128. Endothelial PGC-1α Mediates Vascular Dysfunction in Diabetes

Author

Sawada, Naoki, Jiang, Aihua, Takizawa, Fumihiko, Safdar, Adeel, Manika, Andre, Tesmenitsky, Yevgenia, Kang, Kyu-Tae, Bischoff, Joyce, Kalwa, Hermann, Sartoretto, Juliano L., Kamei, Yasutomi, Benjamin, Laura E., Watada, Hirotaka, Ogawa, Yoshihiro, Higashikuni, Yasutomi, Kessinger, Chase W., Jaffer, Farouc A., Michel, Thomas, Sata, Masataka, Croce, Kevin, Tanaka, Rica, and Arany, Zolt

Published
2014
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130. Inhibition of S1P Receptor 2 Attenuates Endothelial Dysfunction and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice

Author

Ganbaatar, Byambasuren, Fukuda, Daiju, Shinohara, Masakazu, Yagi, Shusuke, Kusunose, Kenya, Yamada, Hirotsugu, Soeki, Takeshi, Hirata, Ken-ichi, and Sata, Masataka

Subjects
Inflammation, S1P2 receptor, lipids (amino acids, peptides, and proteins), Endothelial function, Atherosclerosis, S1P
Abstract

Aim: The bioactive lipid, sphingosine-1-phosphate (S1P), has various roles in the physiology and pathophysiology of many diseases. There are five S1P receptors; however, the role of each S1P receptor in atherogenesis is still obscure. Here we investigated the contribution of S1P receptor 2 (S1P2) to atherogenesis by using a specific S1P2 antagonist, ONO-5430514, in apolipoprotein E-deficient (Apoe−/− ) mice. Methods: Apoe−/− mice fed with a western-type diet (WTD) received ONO-5430514 (30 mg/kg/day) or vehicle. To examine the effect on atherogenesis, Sudan IV staining, histological analysis, qPCR, and vascular reactivity assay was performed. Human umbilical vein endothelial cells (HUVEC) were used for in vitro experiments. Results: WTD-fed Apoe−/− mice had significantly higher S1P2 expression in the aorta compared with wild-type mice. S1P2 antagonist treatment for 20 weeks reduced atherosclerotic lesion development (p＜0.05). S1P2 antagonist treatment for 8 weeks ameliorated endothelial dysfunction (p＜0.05) accompanied with significant reduction of lipid deposition, macrophage accumulation, and inflammatory molecule expression in the aorta compared with vehicle. S1P2 antagonist attenuated the phosphorylation of JNK in the abdominal aorta compared with vehicle (p＜0.05). In HUVEC, S1P promoted inflammatory molecule expression such as MCP-1 and VCAM-1 (p＜0.001), which was attenuated by S1P2 antagonist or a JNK inhibitor (p＜0.01). S1P2 antagonist also inhibited S1P-induced JNK phosphorylation in HUVEC (p＜0.05). Conclusions: Our results suggested that an S1P2 antagonist attenuates endothelial dysfunction and prevents atherogenesis. S1P2, which promotes inflammatory activation of endothelial cells, might be a therapeutic target for atherosclerosis.

Published
2021

131. Infective Endocarditis from Furuncle with Meningitis Complication Caused by Methicillin-resistant Staphylococcus aureus

Author

Yagi, Shusuke, Takahashi, Tomoko, Murakami, Keiji, Azuma, Momoyo, Sugano, Mikio, Miyamoto, Ryosuke, Niki, Mariko, Yamada, Hirotsugu, Kawabata, Yutaka, Tani, Akihiro, Fukuda, Daiju, Kadota, Muneyuki, Ise, Takayuki, Kusunose, Kenya, Tobiume, Takeshi, Matsuura, Tomomi, Yamaguchi, Koji, Soeki, Takeshi, Wakatsuki, Tetsuzo, Hata, Hiroki, and Sata, Masataka

Subjects
Male, Methicillin-Resistant Staphylococcus aureus, Endocarditis, Virulence Factors, Furunculosis, Case Report, USA300, biochemical phenomena, metabolism, and nutrition, Middle Aged, bacterial infections and mycoses, ACME, Animals, Humans, PVL, Meningitis, skin and connective tissue diseases
Abstract

Infective endocarditis (IE) may be acquired in the community as community-acquired (CA) IE or in the healthcare setting. In Japan, cases of CA-methicillin-resistant Staphylococcus aureus (MRSA) infection as skin infection have been increasing. CA-MRSA strains, including the USA300 clone, have higher pathogenicity and are more destructive to tissue than healthcare-associated MRSA strains because of the toxins they produce, including arginine-catabolic mobile element (ACME) and Panton-Valentine leukocidin (PVL). However, only a few IE cases induced by USA300 have been reported. We herein report a 64-year-old man who developed CA-IE from a furuncle caused by USA300 MRSA producing PVL and ACME, which resulted in complications of meningitis.

Published
2021

139. Endothelial Function Is Impaired in Patients Receiving Antihypertensive Drug Treatment Regardless of Blood Pressure Level: FMD-J Study (Flow-Mediated Dilation Japan)

Author

Maruhashi, Tatsuya, Soga, Junko, Fujimura, Noritaka, Idei, Naomi, Mikami, Shinsuke, Iwamoto, Yumiko, Iwamoto, Akimichi, Kajikawa, Masato, Matsumoto, Takeshi, Oda, Nozomu, Kishimoto, Shinji, Matsui, Shogo, Hashimoto, Haruki, Aibara, Yoshiki, Yusoff, Farina Binti Mohamad, Hidaka, Takayuki, Kihara, Yasuki, Chayama, Kazuaki, Noma, Kensuke, Nakashima, Ayumu, Goto, Chikara, Tomiyama, Hirofumi, Takase, Bonpei, Kohro, Takahide, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Watanabe, Kentaro, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Ikeda, Hisao, Yamashina, Akira, and Higashi, Yukihito

Published
2017
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143. Lack of impact of ipragliflozin on endothelial function in patients with type 2 diabetes: sub-analysis of the PROTECT study.

Author

Kishimoto, Shinji, Higashi, Yukihito, Imai, Takumi, Eguchi, Kazuo, Fukumoto, Kazuo, Tomiyama, Hirofumi, Maemura, Koji, Tanaka, Atsushi, Node, Koichi, Murohara, Toyoaki, Kitakaze, Masafumi, Nishio, Yoshihiko, Inoue, Teruo, Ohishi, Mitsuru, Kario, Kazuomi, Sata, Masataka, Shimabukuro, Michio, Shimizu, Wataru, Jinnouchi, Hideaki, and Taguchi, Isao

Subjects
TYPE 2 diabetes, IPRAGLIFLOZIN, BRACHIAL artery
Abstract

Background: We assessed the impact of 24 months of treatment with ipragliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, on endothelial function in patients with type 2 diabetes as a sub-analysis of the PROTECT study. Methods: In the PROTECT study, patients were randomized to receive either standard antihyperglycemic treatment (control group, n = 241) or add-on ipragliflozin treatment (ipragliflozin group, n = 241) in a 1:1 ratio. Among the 482 patients in the PROTECT study, flow-mediated vasodilation (FMD) was assessed in 32 patients in the control group and 26 patients in the ipragliflozin group before and after 24 months of treatment. Results: HbA1c levels significantly decreased after 24 months of treatment compared to the baseline value in the ipragliflozin group, but not in the control group. However, there was no significant difference between the changes in HbA1c levels in the two groups (7.4 ± 0.8% vs. 7.0 ± 0.9% in the ipragliflozin group and 7.4 ± 0.7% vs. 7.3 ± 0.7% in the control group; P = 0.08). There was no significant difference between FMD values at baseline and after 24 months in both groups (5.2 ± 2.6% vs. 5.2 ± 2.6%, P = 0.98 in the ipragliflozin group; 5.4 ± 2.9% vs. 5.0 ± 3.2%, P = 0.34 in the control group). There was no significant difference in the estimated percentage change in FMD between the two groups (P = 0.77). Conclusions: Over a 24-month period, the addition of ipragliflozin to standard therapy in patients with type 2 diabetes did not change endothelial function assessed by FMD in the brachial artery. Trial registration: Registration Number for Clinical Trial: jRCT1071220089 (https://jrct.niph.go.jp/en-latest-detail/jRCT1071220089). [ABSTRACT FROM AUTHOR]

Published
2023
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144. New quantitative indices of cardiac amyloidosis with 99mTc-pyrophosphate scintigraphy.

Author

Matsuda, Noritake, Otsuka, Hideki, Otani, Tamaki, Azane, Shota, Kunikane, Yamato, Otomi, Yoichi, Ueki, Yuya, Kubota, Masahiro, Amano, Masafumi, Yagi, Shusuke, Sata, Masataka, and Harada, Masafumi

Abstract

Purpose: Amyloid light chain (AL) and transthyretin (ATTR) are the major subtypes of cardiac amyloidosis (CA). 99mTc-pyrophosphate (PYP) scintigraphy is used to differentiate ATTR from other CA subtypes. We adapted the standardized uptake value (SUV) for 99mTc-PYP and proposed two quantitative indices, amyloid deposition volume (AmyDV) and total amyloid uptake (TAU). This study aimed to evaluate the utility of these quantitative indices in differentiating ATTR from non-ATTRs. Materials and methods: Before the SUV measurement, the Becquerel calibration factor (BCF) of 99mTc was obtained by a phantom experiment. Thirty-two patients who had undergone hybrid SPECT/CT imaging 3 h after injection of 99mTc-PYP (370 MBq) were studied. CT attenuation correction for image reconstruction was applied in all. We calculated SUV, AmyDV, and TAU using a quantitative analysis software program for bone SPECT (GI-BONE) and analyzed AmyDV using two methods: threshold method (set 40%); and constant value method (average SUVmax of ribs). We assessed the diagnostic ability of heart-to-contralateral lung (H/CL) ratio, SUV, AmyDV, and TAU to differentiate ATTR from non-ATTR using receiver operating characteristic (ROC) analysis. Results: Statistically significant differences in all quantitative indices were observed between ATTR and non-ATTR. The area under the curve of each quantitative index for discriminating between ATTR and non-ATTR were as follows: H/CL, 0.997; SUVmax, 0.953; SUVmean (M1), 0.964; SUVmean (M2), 0.969; AmyDV (M1), 0.875; AmyDV (M2), 0.974; and TAU, 0.974. The AmyDV (M2) had higher diagnostic ability than AmyDV (M1). Thus, TAU was calculated as AmyDV (M2) × SUVmean (M2). In the ROC curve, SUV, AmyDV, and TAU had almost the same diagnostic ability as H/CL in distinguishing ATTR from non-ATTRs. Conclusions: We propose two novel 3D-based quantitative parameters (AmyDV and TAU) that have almost equal ability to discriminate ATTR from non-ATTR. [ABSTRACT FROM AUTHOR]

Published
2023
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