Author: "Salatino, P" - Searchworks@Jio Institute Digital Library Search Results

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101. 1466 Galectin-1 orchestrates a hierarchical tumor to stromal extracellular vesicles system that fosters immune suppression

Author: Joaquin P Merlo, Camila A Bach, Ada Blidner, Ramiro Perrotta, Mariana Salatino, and Gabriel Rabinovich
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2023
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102. Effect of Heating Rate on the Performances of HTL Applied to a Sewage Sludge

Author: Marco Balsamo, Fabio Montagnaro, Francesca Di Lauro, Piero Salatino, and Roberto Solimene
Subjects: Chemical engineering, TP155-156, Computer engineering. Computer hardware, TK7885-7895
Abstract: The use of renewable energies and the energy exploitation of residual biomass have become prominent topics in the context of sustainable development goals. From a circular economy perspective, among the different types of biomasses, those defined as “waste” such as sewage sludge are of particular interest since significant volumes of municipal/industrial sludge are discharged into landfills at great cost to the industry and with associated negative environmental impacts. In this context, the hydrothermal liquefaction (HTL) process, working with water in sub-critical conditions, appears to be a promising and still limitedly explored route (as compared with other thermochemical processes) to obtain biofuel from biomass characterised by a high moisture content such as sludge. However, most of the literature studies are based on HTL experiments performed in small-scale batch reactors (generally a few mL), not allowing for proper assessing the effect of thermal transients, which instead occur in larger-scale systems, on product yields and quality. In this work, the set-up of a 500 mL lab-scale HTL apparatus was optimized so as to limit the duration of thermal transients, and preliminary tests were carried out on a municipal sludge to evaluate the yield and quality of the bio-crude obtained at different heating rates.
Published: 2023
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103. Available Assistive Technology Outcome Measures: Systematic Review

Author: Francesca Borgnis, Lorenzo Desideri, Rosa Maria Converti, and Claudia Salatino
Subjects: Medical technology, R855-855.5
Abstract: BackgroundThe World Health Organization claimed that measuring outcomes is necessary to understand the benefits of assistive technology (AT) and create evidence-based policies and systems to ensure universal access to it. In clinical practice, there is an increasing need for standardized methods to track AT interventions using outcome assessments. ObjectiveThis review provides an overview of the available outcome measures that can be used at the follow-up stage of any AT intervention and integrated into daily clinical or service practice. MethodsWe systematically searched for original manuscripts regarding available and used AT outcome measures by searching for titles and abstracts in the PubMed, Scopus, and Web of Science databases up to March 2023. ResultsWe analyzed 955 articles, of which 50 (5.2%) were included in the review. Within these, 53 instruments have been mentioned and used to provide an AT outcome assessment. The most widely used tool is the Quebec User Evaluation of Satisfaction with Assistive Technology, followed by the Psychosocial Impact of Assistive Technology Scale. Moreover, the identified measures addressed 8 AT outcome domains: functional efficacy, satisfaction, psychosocial impact, caregiver burden, quality of life, participation, confidence, and usability. The AT category Assistive products for activities and participation relating to personal mobility and transportation was the most involved in the reviewed articles. ConclusionsAmong the 53 cited instruments, only 17 (32%) scales were designed to evaluate specifically assistive devices. Moreover, 64% (34/53) of the instruments were only mentioned once to denote poor uniformity and concordance in the instruments to be used, limiting the possibility of comparing the results of studies. This work could represent a good guide for promoting the use of validated AT outcome measures in clinical practice that can be helpful to AT assessment teams in their everyday activities and the improvement of clinical practice.
Published: 2023
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104. QUBIC: using NbSi TESs with a bolometric interferometer to characterize the polarisation of the CMB

Author: Piat, M., Bélier, B., Bergé, L., Bleurvacq, N., Chapron, C., Dheilly, S., Dumoulin, L., González, M., Grandsire, L., Hamilton, J. -Ch., Henrot-Versillé, S., Hoang, D. T., Marnieros, S., Marty, W., Montier, L., Olivieri, E., Oriol, C., Perbost, C., Prêle, D., Rambaud, D., Salatino, M., Stankowiak, G., Thermeau, J. -P., Torchinsky, S., Voisin, F., Ade, P., Alberro, J. G., Almela, A., Amico, G., Arnaldi, L. H., Auguste, D., Aumont, J., Azzoni, S., Banfi, S., Battaglia, P., Battistelli, E. S., Baù, A., Bennett, D., Bernard, J. -Ph., Bersanelli, M., Bigot-Sazy, M. -A., Bonaparte, J., Bonis, J., Bottani, A., Bunn, E., Burke, D., Buzi, D., Buzzelli, A., Cavaliere, F., Chanial, P., Charlassier, R., Columbro, F., Coppi, G., Coppolecchia, A., D'Alessandro, G., de Bernardis, P., De Gasperis, G., De Leo, M., De Petris, M., Di Donato, A., Etchegoyen, A., Fasciszewski, A., Ferreyro, L. P., Fracchia, D., Franceschet, C., Lerena, M. M. Gamboa, Ganga, K., García, B., Redondo, M. E. García, Gaspard, M., Gault, A., Gayer, D., Gervasi, M., Giard, M., Gilles, V., Giraud-Heraud, Y., Berisso, M. Gómez, Gradziel, M., Harari, D., Haynes, V., Incardona, F., Jules, E., Kaplan, J., Korotkov, A., Kristukat, C., Lamagna, L., Loucatos, S., Louis, T., Luterstein, R., Maffei, B., Masi, S., Mattei, A., May, A., McCulloch, M., Medina, M. C., Mele, L., Melhuish, S., Mennella, A., Mousset, L., Mundo, L. M., Murphy, J. A., Murphy, J. D., Nati, F., O'Sullivan, C., Paiella, A., Pajot, F., Passerini, A., Pastoriza, H., Pelosi, A., Perciballi, M., Pezzotta, F., Piacentini, F., Piccirillo, L., Pisano, G., Platino, M., Polenta, G., Puddu, R., Ringegni, P., Romero, G. E., Salum, J. M., Schillaci, A., Scóccola, C., Scully, S., Spinelli, S., Stolpovskiy, M., Suarez, F., Tartari, A., Timbie, P., Tomasi, M., Tucker, C., Tucker, G., Vanneste, S., Viganò, D., Vittorio, N., Watson, B., Wicek, F., Zannoni, M., and Zullo, A.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: QUBIC (Q \& U Bolometric Interferometer for Cosmology) is an international ground-based experiment dedicated in the measurement of the polarized fluctuations of the Cosmic Microwave Background (CMB). It is based on bolometric interferometry, an original detection technique which combine the immunity to systematic effects of an interferometer with the sensitivity of low temperature incoherent detectors. QUBIC will be deployed in Argentina, at the Alto Chorrillos mountain site near San Antonio de los Cobres, in the Salta province. The QUBIC detection chain consists in 2048 NbSi Transition Edge Sensors (TESs) cooled to 350mK.The voltage-biased TESs are read out with Time Domain Multiplexing based on Superconducting QUantum Interference Devices (SQUIDs) at 1 K and a novel SiGe Application-Specific Integrated Circuit (ASIC) at 60 K allowing to reach an unprecedented multiplexing (MUX) factor equal to 128. The QUBIC experiment is currently being characterized in the lab with a reduced number of detectors before upgrading to the full instrument. I will present the last results of this characterization phase with a focus on the detectors and readout system., Comment: Conference proceedings submitted to the Journal of Low Temperature Physics for LTD18
Published: 2019

105. Early Detection of Research Trends

Author: Salatino, Angelo Antonio
Subjects: Computer Science - Social and Information Networks, Computer Science - Digital Libraries, Computer Science - Information Retrieval, Physics - Physics and Society
Abstract: Being able to rapidly recognise new research trends is strategic for many stakeholders, including universities, institutional funding bodies, academic publishers and companies. The literature presents several approaches to identifying the emergence of new research topics, which rely on the assumption that the topic is already exhibiting a certain degree of popularity and consistently referred to by a community of researchers. However, detecting the emergence of a new research area at an embryonic stage, i.e., before the topic has been consistently labelled by a community of researchers and associated with a number of publications, is still an open challenge. In this dissertation, we begin to address this challenge by performing a study of the dynamics preceding the creation of new topics. This study indicates that the emergence of a new topic is anticipated by a significant increase in the pace of collaboration between relevant research areas, which can be seen as the 'ancestors' of the new topic. Based on this understanding, we developed Augur, a novel approach to effectively detecting the emergence of new research topics. Augur analyses the diachronic relationships between research areas and is able to detect clusters of topics that exhibit dynamics correlated with the emergence of new research topics. Here we also present the Advanced Clique Percolation Method (ACPM), a new community detection algorithm developed specifically for supporting this task. Augur was evaluated on a gold standard of 1,408 debutant topics in the 2000-2011 timeframe and outperformed four alternative approaches in terms of both precision and recall., Comment: This dissertation is submitted for the Degree of Doctor of Philosophy
Published: 2019

106. CMB-S4 Decadal Survey APC White Paper

Author: Abazajian, Kevork, Addison, Graeme, Adshead, Peter, Ahmed, Zeeshan, Allen, Steven W., Alonso, David, Alvarez, Marcelo, Amin, Mustafa A., Anderson, Adam, Arnold, Kam S., Baccigalupi, Carlo, Bailey, Kathy, Barkats, Denis, Barron, Darcy, Barry, Peter S., Bartlett, James G., Thakur, Ritoban Basu, Battaglia, Nicholas, Baxter, Eric, Bean, Rachel, Bebek, Chris, Bender, Amy N., Benson, Bradford A., Berger, Edo, Bhimani, Sanah, Bischoff, Colin A., Bleem, Lindsey, Bock, James J., Bocquet, Sebastian, Boddy, Kimberly, Bonato, Matteo, Bond, J. Richard, Borrill, Julian, Bouchet, François R., Brown, Michael L., Bryan, Sean, Burkhart, Blakesley, Buza, Victor, Byrum, Karen, Calabrese, Erminia, Calafut, Victoria, Caldwell, Robert, Carlstrom, John E., Carron, Julien, Cecil, Thomas, Challinor, Anthony, Chang, Clarence L., Chinone, Yuji, Cho, Hsiao-Mei Sherry, Cooray, Asantha, Crawford, Thomas M., Crites, Abigail, Cukierman, Ari, Cyr-Racine, Francis-Yan, de Haan, Tijmen, de Zotti, Gianfranco, Delabrouille, Jacques, Demarteau, Marcel, Devlin, Mark, Di Valentino, Eleonora, Dobbs, Matt, Duff, Shannon, Duivenvoorden, Adriaan, Dvorkin, Cora, Edwards, William, Eimer, Joseph, Errard, Josquin, Essinger-Hileman, Thomas, Fabbian, Giulio, Feng, Chang, Ferraro, Simone, Filippini, Jeffrey P., Flauger, Raphael, Flaugher, Brenna, Fraisse, Aurelien A., Frolov, Andrei, Galitzki, Nicholas, Galli, Silvia, Ganga, Ken, Gerbino, Martina, Gilchriese, Murdock, Gluscevic, Vera, Green, Daniel, Grin, Daniel, Grohs, Evan, Gualtieri, Riccardo, Guarino, Victor, Gudmundsson, Jon E., Habib, Salman, Haller, Gunther, Halpern, Mark, Halverson, Nils W., Hanany, Shaul, Harrington, Kathleen, Hasegawa, Masaya, Hasselfield, Matthew, Hazumi, Masashi, Heitmann, Katrin, Henderson, Shawn, Henning, Jason W., Hill, J. Colin, Hlozek, Renée, Holder, Gil, Holzapfel, William, Hubmayr, Johannes, Huffenberger, Kevin M., Huffer, Michael, Hui, Howard, Irwin, Kent, Johnson, Bradley R., Johnstone, Doug, Jones, William C., Karkare, Kirit, Katayama, Nobuhiko, Kerby, James, Kernovsky, Sarah, Keskitalo, Reijo, Kisner, Theodore, Knox, Lloyd, Kosowsky, Arthur, Kovac, John, Kovetz, Ely D., Kuhlmann, Steve, Kuo, Chao-lin, Kurita, Nadine, Kusaka, Akito, Lahteenmaki, Anne, Lawrence, Charles R., Lee, Adrian T., Lewis, Antony, Li, Dale, Linder, Eric, Loverde, Marilena, Lowitz, Amy, Madhavacheril, Mathew S., Mantz, Adam, Matsuda, Frederick, Mauskopf, Philip, McMahon, Jeff, Meerburg, P. Daniel, Melin, Jean-Baptiste, Meyers, Joel, Millea, Marius, Mohr, Joseph, Moncelsi, Lorenzo, Mroczkowski, Tony, Mukherjee, Suvodip, Münchmeyer, Moritz, Nagai, Daisuke, Nagy, Johanna, Namikawa, Toshiya, Nati, Federico, Natoli, Tyler, Negrello, Mattia, Newburgh, Laura, Niemack, Michael D., Nishino, Haruki, Nordby, Martin, Novosad, Valentine, O'Connor, Paul, Obied, Georges, Padin, Stephen, Pandey, Shivam, Partridge, Bruce, Pierpaoli, Elena, Pogosian, Levon, Pryke, Clement, Puglisi, Giuseppe, Racine, Benjamin, Raghunathan, Srinivasan, Rahlin, Alexandra, Rajagopalan, Srini, Raveri, Marco, Reichanadter, Mark, Reichardt, Christian L., Remazeilles, Mathieu, Rocha, Graca, Roe, Natalie A., Roy, Anirban, Ruhl, John, Salatino, Maria, Saliwanchik, Benjamin, Schaan, Emmanuel, Schillaci, Alessandro, Schmittfull, Marcel M., Scott, Douglas, Sehgal, Neelima, Shandera, Sarah, Sheehy, Christopher, Sherwin, Blake D., Shirokoff, Erik, Simon, Sara M., Slosar, Anze, Somerville, Rachel, Staggs, Suzanne T., Stark, Antony, Stompor, Radek, Story, Kyle T., Stoughton, Chris, Suzuki, Aritoki, Tajima, Osamu, Teply, Grant P., Thompson, Keith, Timbie, Peter, Tomasi, Maurizio, Treu, Jesse I., Tristram, Matthieu, Tucker, Gregory, Umiltà, Caterina, van Engelen, Alexander, Vieira, Joaquin D., Vieregg, Abigail G., Vogelsberger, Mark, Wang, Gensheng, Watson, Scott, White, Martin, Whitehorn, Nathan, Wollack, Edward J., Wu, W. L. Kimmy, Xu, Zhilei, Yasini, Siavash, Yeck, James, Yoon, Ki Won, Young, Edward, and Zonca, Andrea
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract: We provide an overview of the science case, instrument configuration and project plan for the next-generation ground-based cosmic microwave background experiment CMB-S4, for consideration by the 2020 Decadal Survey., Comment: Project White Paper submitted to the 2020 Decadal Survey, 10 pages plus references. arXiv admin note: substantial text overlap with arXiv:1907.04473
Published: 2019

107. The Simons Observatory: Astro2020 Decadal Project Whitepaper

Author: The Simons Observatory Collaboration, Abitbol, Maximilian H., Adachi, Shunsuke, Ade, Peter, Aguirre, James, Ahmed, Zeeshan, Aiola, Simone, Ali, Aamir, Alonso, David, Alvarez, Marcelo A., Arnold, Kam, Ashton, Peter, Atkins, Zachary, Austermann, Jason, Awan, Humna, Baccigalupi, Carlo, Baildon, Taylor, Lizancos, Anton Baleato, Barron, Darcy, Battaglia, Nick, Battye, Richard, Baxter, Eric, Bazarko, Andrew, Beall, James A., Bean, Rachel, Beck, Dominic, Beckman, Shawn, Beringue, Benjamin, Bhandarkar, Tanay, Bhimani, Sanah, Bianchini, Federico, Boada, Steven, Boettger, David, Bolliet, Boris, Bond, J. Richard, Borrill, Julian, Brown, Michael L., Bruno, Sarah Marie, Bryan, Sean, Calabrese, Erminia, Calafut, Victoria, Calisse, Paolo, Carron, Julien, Carl, Fred. M, Cayuso, Juan, Challinor, Anthony, Chesmore, Grace, Chinone, Yuji, Chluba, Jens, Cho, Hsiao-Mei Sherry, Choi, Steve, Clark, Susan, Clarke, Philip, Contaldi, Carlo, Coppi, Gabriele, Cothard, Nicholas F., Coughlin, Kevin, Coulton, Will, Crichton, Devin, Crowley, Kevin D., Crowley, Kevin T., Cukierman, Ari, D'Ewart, John M., Dünner, Rolando, de Haan, Tijmen, Devlin, Mark, Dicker, Simon, Dober, Bradley, Duell, Cody J., Duff, Shannon, Duivenvoorden, Adri, Dunkley, Jo, Bouhargani, Hamza El, Errard, Josquin, Fabbian, Giulio, Feeney, Stephen, Fergusson, James, Ferraro, Simone, Fluxà, Pedro, Freese, Katherine, Frisch, Josef C., Frolov, Andrei, Fuller, George, Galitzki, Nicholas, Gallardo, Patricio A., Ghersi, Jose Tomas Galvez, Gao, Jiansong, Gawiser, Eric, Gerbino, Martina, Gluscevic, Vera, Goeckner-Wald, Neil, Golec, Joseph, Gordon, Sam, Gralla, Megan, Green, Daniel, Grigorian, Arpi, Groh, John, Groppi, Chris, Guan, Yilun, Gudmundsson, Jon E., Halpern, Mark, Han, Dongwon, Hargrave, Peter, Harrington, Kathleen, Hasegawa, Masaya, Hasselfield, Matthew, Hattori, Makoto, Haynes, Victor, Hazumi, Masashi, Healy, Erin, Henderson, Shawn W., Hensley, Brandon, Hervias-Caimapo, Carlos, Hill, Charles A., Hill, J. Colin, Hilton, Gene, Hilton, Matt, Hincks, Adam D., Hinshaw, Gary, Hložek, Renée, Ho, Shirley, Ho, Shuay-Pwu Patty, Hoang, Thuong D., Hoh, Jonathan, Hotinli, Selim C., Huang, Zhiqi, Hubmayr, Johannes, Huffenberger, Kevin, Hughes, John P., Ijjas, Anna, Ikape, Margaret, Irwin, Kent, Jaffe, Andrew H., Jain, Bhuvnesh, Jeong, Oliver, Johnson, Matthew, Kaneko, Daisuke, Karpel, Ethan D., Katayama, Nobuhiko, Keating, Brian, Keskitalo, Reijo, Kisner, Theodore, Kiuchi, Kenji, Klein, Jeff, Knowles, Kenda, Kofman, Anna, Koopman, Brian, Kosowsky, Arthur, Krachmalnicoff, Nicoletta, Kusaka, Akito, LaPlante, Phil, Lashner, Jacob, Lee, Adrian, Lee, Eunseong, Lewis, Antony, Li, Yaqiong, Li, Zack, Limon, Michele, Linder, Eric, Liu, Jia, Lopez-Caraballo, Carlos, Louis, Thibaut, Lungu, Marius, Madhavacheril, Mathew, Mak, Daisy, Maldonado, Felipe, Mani, Hamdi, Mates, Ben, Matsuda, Frederick, Maurin, Loïc, Mauskopf, Phil, May, Andrew, McCallum, Nialh, McCarrick, Heather, McKenney, Chris, McMahon, Jeff, Meerburg, P. Daniel, Mertens, James, Meyers, Joel, Miller, Amber, Mirmelstein, Mark, Moodley, Kavilan, Moore, Jenna, Munchmeyer, Moritz, Munson, Charles, Murata, Masaaki, Naess, Sigurd, Namikawa, Toshiya, Nati, Federico, Navaroli, Martin, Newburgh, Laura, Nguyen, Ho Nam, Nicola, Andrina, Niemack, Mike, Nishino, Haruki, Nishinomiya, Yume, Orlowski-Scherer, John, Pagano, Luca, Partridge, Bruce, Perrotta, Francesca, Phakathi, Phumlani, Piccirillo, Lucio, Pierpaoli, Elena, Pisano, Giampaolo, Poletti, Davide, Puddu, Roberto, Puglisi, Giuseppe, Raum, Chris, Reichardt, Christian L., Remazeilles, Mathieu, Rephaeli, Yoel, Riechers, Dominik, Rojas, Felipe, Rotti, Aditya, Roy, Anirban, Sadeh, Sharon, Sakurai, Yuki, Salatino, Maria, Rao, Mayuri Sathyanarayana, Saunders, Lauren, Schaan, Emmanuel, Schmittfull, Marcel, Sehgal, Neelima, Seibert, Joseph, Seljak, Uros, Shellard, Paul, Sherwin, Blake, Shimon, Meir, Sierra, Carlos, Sievers, Jonathan, Sifon, Cristobal, Sikhosana, Precious, Silva-Feaver, Maximiliano, Simon, Sara M., Sinclair, Adrian, Smith, Kendrick, Sohn, Wuhyun, Sonka, Rita, Spergel, David, Spisak, Jacob, Staggs, Suzanne T., Stein, George, Stevens, Jason R., Stompor, Radek, Suzuki, Aritoki, Tajima, Osamu, Takakura, Satoru, Teply, Grant, Thomas, Daniel B., Thorne, Ben, Thornton, Robert, Trac, Hy, Treu, Jesse, Tsai, Calvin, Tucker, Carole, Ullom, Joel, Vagnozzi, Sunny, van Engelen, Alexander, Van Lanen, Jeff, Van Winkle, Daniel D., Vavagiakis, Eve M., Vergès, Clara, Vissers, Michael, Wagoner, Kasey, Walker, Samantha, Wang, Yuhan, Ward, Jon, Westbrook, Ben, Whitehorn, Nathan, Williams, Jason, Williams, Joel, Wollack, Edward, Xu, Zhilei, Yasini, Siavash, Young, Edward, Yu, Byeonghee, Yu, Cyndia, Zago, Fernando, Zannoni, Mario, Zhang, Hezi, Zheng, Kaiwen, Zhu, Ningfeng, and Zonca, Andrea
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Simons Observatory (SO) is a ground-based cosmic microwave background (CMB) experiment sited on Cerro Toco in the Atacama Desert in Chile that promises to provide breakthrough discoveries in fundamental physics, cosmology, and astrophysics. Supported by the Simons Foundation, the Heising-Simons Foundation, and with contributions from collaborating institutions, SO will see first light in 2021 and start a five year survey in 2022. SO has 287 collaborators from 12 countries and 53 institutions, including 85 students and 90 postdocs. The SO experiment in its currently funded form ('SO-Nominal') consists of three 0.4 m Small Aperture Telescopes (SATs) and one 6 m Large Aperture Telescope (LAT). Optimized for minimizing systematic errors in polarization measurements at large angular scales, the SATs will perform a deep, degree-scale survey of 10% of the sky to search for the signature of primordial gravitational waves. The LAT will survey 40% of the sky with arc-minute resolution. These observations will measure (or limit) the sum of neutrino masses, search for light relics, measure the early behavior of Dark Energy, and refine our understanding of the intergalactic medium, clusters and the role of feedback in galaxy formation. With up to ten times the sensitivity and five times the angular resolution of the Planck satellite, and roughly an order of magnitude increase in mapping speed over currently operating ("Stage 3") experiments, SO will measure the CMB temperature and polarization fluctuations to exquisite precision in six frequency bands from 27 to 280 GHz. SO will rapidly advance CMB science while informing the design of future observatories such as CMB-S4., Comment: Astro2020 Decadal Project Whitepaper. arXiv admin note: text overlap with arXiv:1808.07445
Published: 2019

108. CMB-S4 Science Case, Reference Design, and Project Plan

Author: Abazajian, Kevork, Addison, Graeme, Adshead, Peter, Ahmed, Zeeshan, Allen, Steven W., Alonso, David, Alvarez, Marcelo, Anderson, Adam, Arnold, Kam S., Baccigalupi, Carlo, Bailey, Kathy, Barkats, Denis, Barron, Darcy, Barry, Peter S., Bartlett, James G., Thakur, Ritoban Basu, Battaglia, Nicholas, Baxter, Eric, Bean, Rachel, Bebek, Chris, Bender, Amy N., Benson, Bradford A., Berger, Edo, Bhimani, Sanah, Bischoff, Colin A., Bleem, Lindsey, Bocquet, Sebastian, Boddy, Kimberly, Bonato, Matteo, Bond, J. Richard, Borrill, Julian, Bouchet, François R., Brown, Michael L., Bryan, Sean, Burkhart, Blakesley, Buza, Victor, Byrum, Karen, Calabrese, Erminia, Calafut, Victoria, Caldwell, Robert, Carlstrom, John E., Carron, Julien, Cecil, Thomas, Challinor, Anthony, Chang, Clarence L., Chinone, Yuji, Cho, Hsiao-Mei Sherry, Cooray, Asantha, Crawford, Thomas M., Crites, Abigail, Cukierman, Ari, Cyr-Racine, Francis-Yan, de Haan, Tijmen, de Zotti, Gianfranco, Delabrouille, Jacques, Demarteau, Marcel, Devlin, Mark, Di Valentino, Eleonora, Dobbs, Matt, Duff, Shannon, Duivenvoorden, Adriaan, Dvorkin, Cora, Edwards, William, Eimer, Joseph, Errard, Josquin, Essinger-Hileman, Thomas, Fabbian, Giulio, Feng, Chang, Ferraro, Simone, Filippini, Jeffrey P., Flauger, Raphael, Flaugher, Brenna, Fraisse, Aurelien A., Frolov, Andrei, Galitzki, Nicholas, Galli, Silvia, Ganga, Ken, Gerbino, Martina, Gilchriese, Murdock, Gluscevic, Vera, Green, Daniel, Grin, Daniel, Grohs, Evan, Gualtieri, Riccardo, Guarino, Victor, Gudmundsson, Jon E., Habib, Salman, Haller, Gunther, Halpern, Mark, Halverson, Nils W., Hanany, Shaul, Harrington, Kathleen, Hasegawa, Masaya, Hasselfield, Matthew, Hazumi, Masashi, Heitmann, Katrin, Henderson, Shawn, Henning, Jason W., Hill, J. Colin, Hlozek, Renée, Holder, Gil, Holzapfel, William, Hubmayr, Johannes, Huffenberger, Kevin M., Huffer, Michael, Hui, Howard, Irwin, Kent, Johnson, Bradley R., Johnstone, Doug, Jones, William C., Karkare, Kirit, Katayama, Nobuhiko, Kerby, James, Kernovsky, Sarah, Keskitalo, Reijo, Kisner, Theodore, Knox, Lloyd, Kosowsky, Arthur, Kovac, John, Kovetz, Ely D., Kuhlmann, Steve, Kuo, Chao-lin, Kurita, Nadine, Kusaka, Akito, Lahteenmaki, Anne, Lawrence, Charles R., Lee, Adrian T., Lewis, Antony, Li, Dale, Linder, Eric, Loverde, Marilena, Lowitz, Amy, Madhavacheril, Mathew S., Mantz, Adam, Matsuda, Frederick, Mauskopf, Philip, McMahon, Jeff, McQuinn, Matthew, Meerburg, P. Daniel, Melin, Jean-Baptiste, Meyers, Joel, Millea, Marius, Mohr, Joseph, Moncelsi, Lorenzo, Mroczkowski, Tony, Mukherjee, Suvodip, Münchmeyer, Moritz, Nagai, Daisuke, Nagy, Johanna, Namikawa, Toshiya, Nati, Federico, Natoli, Tyler, Negrello, Mattia, Newburgh, Laura, Niemack, Michael D., Nishino, Haruki, Nordby, Martin, Novosad, Valentine, O'Connor, Paul, Obied, Georges, Padin, Stephen, Pandey, Shivam, Partridge, Bruce, Pierpaoli, Elena, Pogosian, Levon, Pryke, Clement, Puglisi, Giuseppe, Racine, Benjamin, Raghunathan, Srinivasan, Rahlin, Alexandra, Rajagopalan, Srini, Raveri, Marco, Reichanadter, Mark, Reichardt, Christian L., Remazeilles, Mathieu, Rocha, Graca, Roe, Natalie A., Roy, Anirban, Ruhl, John, Salatino, Maria, Saliwanchik, Benjamin, Schaan, Emmanuel, Schillaci, Alessandro, Schmittfull, Marcel M., Scott, Douglas, Sehgal, Neelima, Shandera, Sarah, Sheehy, Christopher, Sherwin, Blake D., Shirokoff, Erik, Simon, Sara M., Slosar, Anze, Somerville, Rachel, Spergel, David, Staggs, Suzanne T., Stark, Antony, Stompor, Radek, Story, Kyle T., Stoughton, Chris, Suzuki, Aritoki, Tajima, Osamu, Teply, Grant P., Thompson, Keith, Timbie, Peter, Tomasi, Maurizio, Treu, Jesse I., Tristram, Matthieu, Tucker, Gregory, Umiltà, Caterina, van Engelen, Alexander, Vieira, Joaquin D., Vieregg, Abigail G., Vogelsberger, Mark, Wang, Gensheng, Watson, Scott, White, Martin, Whitehorn, Nathan, Wollack, Edward J., Wu, W. L. Kimmy, Xu, Zhilei, Yasini, Siavash, Yeck, James, Yoon, Ki Won, Young, Edward, and Zonca, Andrea
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Astrophysics of Galaxies, High Energy Physics - Experiment
Abstract: We present the science case, reference design, and project plan for the Stage-4 ground-based cosmic microwave background experiment CMB-S4., Comment: 287 pages, 82 figures
Published: 2019

109. The geometry of the magnetic field in the Central Molecular Zone measured by PILOT

Author: Mangilli, A., Aumont, J., Bernard, J. -Ph., Buzzelli, A., de Gasperis, G., Durrive, J. B., Ferrière, K., Foënard, G., Hughes, A., Lacourt, A., Misawa, R., Montier, L., Mot, B., Ristorcelli, I., Roussel, H., Ade, P., Alina, D., de Bernardis, P., Pino, E. de Gouveia Dal, Dubois, J. P., Engel, C., Hargrave, P., Laureijs, R., Longval, Y., Maffei, B., Magalhães, A. M., Marty, C., Masi, S., Montel, J., Pajot, F., Rodriguez, L., Salatino, M., Saccoccio, M., Stever, S., Tauber, J., Tibbs, C., and Tucker, C.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: We present the first far infrared (FIR) dust emission polarization map covering the full extent Milky Way's Central molecular zone (CMZ). The data, obtained with the PILOT balloon-borne experiment, covers the Galactic Center region $-2\,^\circ
Published: 2019
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110. Dissipative dynamics in quantum key distribution

Author: Salatino, L., Mariani, L., Attanasio, C., Pagano, S., and Citro, R.
Published: 2023
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111. The Atacama Cosmology Telescope: Weighing Distant Clusters with the Most Ancient Light

Author: Madhavacheril, Mathew S, Sifón, Cristóbal, Battaglia, Nicholas, Aiola, Simone, Amodeo, Stefania, Austermann, Jason E, Beall, James A, Becker, Daniel T, Bond, J Richard, Calabrese, Erminia, Choi, Steve K, Denison, Edward V, Devlin, Mark J, Dicker, Simon R, Duff, Shannon M, Duivenvoorden, Adriaan J, Dunkley, Jo, Dünner, Rolando, Ferraro, Simone, Gallardo, Patricio A, Guan, Yilun, Han, Dongwon, Hill, J Colin, Hilton, Gene C, Hilton, Matt, Hubmayr, Johannes, Huffenberger, Kevin M, Hughes, John P, Koopman, Brian J, Kosowsky, Arthur, Van Lanen, Jeff, Lee, Eunseong, Louis, Thibaut, MacInnis, Amanda, McMahon, Jeffrey, Moodley, Kavilan, Naess, Sigurd, Namikawa, Toshiya, Nati, Federico, Newburgh, Laura, Niemack, Michael D, Page, Lyman A, Partridge, Bruce, Qu, Frank J, Robertson, Naomi C, Salatino, Maria, Schaan, Emmanuel, Schillaci, Alessandro, Schmitt, Benjamin L, Sehgal, Neelima, Sherwin, Blake D, Simon, Sara M, Spergel, David N, Staggs, Suzanne, Storer, Emilie R, Ullom, Joel N, Vale, Leila R, van Engelen, Alexander, Vavagiakis, Eve M, Wollack, Edward J, and Xu, Zhilei
Subjects: Astronomical Sciences, Physical Sciences, Cosmology, High-redshift galaxy clusters, Cosmic microwave background radiation, Gravitational lensing, astro-ph.CO, astro-ph.GA, Astronomical and Space Sciences, Astronomy & Astrophysics, Astronomical sciences, Space sciences
Abstract: We use gravitational lensing of the cosmic microwave background (CMB) to measure the mass of the most distant blindly selected sample of galaxy clusters on which a lensing measurement has been performed to date. In CMB data from the the Atacama Cosmology Telescope and the Planck satellite, we detect the stacked lensing effect from 677 near-infrared-selected galaxy clusters from the Massive and Distant Clusters of WISE Survey (MaDCoWS), which have a mean redshift of zñ = 1.08. There are currently no representative optical weak lensing measurements of clusters that match the distance and average mass of this sample. We detect the lensing signal with a significance of 4.2s. We model the signal with a halo model framework to find the mean mass of the population from which these clusters are drawn. Assuming that the clusters follow Navarro–Frenk–White (NFW) density profiles, we infer a mean mass of M500cñ = (1.7 + 0.4) ´ 1014 M*. We consider systematic uncertainties from cluster redshift errors, centering errors, and the shape of the NFW profile. These are all smaller than 30% of our reported uncertainty. This work highlights the potential of CMB lensing to enable cosmological constraints from the abundance of distant clusters populating ever larger volumes of the observable universe, beyond the capabilities of optical weak lensing measurements.
Published: 2020

112. Data-Driven Methodology for Knowledge Graph Generation Within the Tourism Domain

Author: Alessandro Chessa, Gianni Fenu, Enrico Motta, Francesco Osborne, Diego Reforgiato Recupero, Angelo Salatino, and Luca Secchi
Subjects: Knowledge graphs, ontology design, tourism ontology, web science, web mining, tourism, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract: The tourism and hospitality sectors have become increasingly important in the last few years and the companies operating in this field are constantly challenged with providing new innovative services. At the same time, (big-) data has become the “new oil” of this century and Knowledge Graphs are emerging as the most natural way to collect, refine, and structure this heterogeneous information. In this paper, we present a methodology for semi-automatic generating a Tourism Knowledge Graph (TKG), which can be used for supporting a variety of intelligent services in this space, and a new ontology for modelling this domain, the Tourism Analytics Ontology (TAO). Our approach processes and integrates data from Booking.com, Airbnb, DBpedia, and GeoNames. Due to its modular structure, it can be easily extended to include new data sources or to apply new enrichment and refinement functions. We report a comprehensive evaluation of the functional, logical, and structural dimensions of TKG and TAO.
Published: 2023
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113. Integrating Conversational Agents and Knowledge Graphs Within the Scholarly Domain

Author: Antonello Meloni, Simone Angioni, Angelo Salatino, Francesco Osborne, Diego Reforgiato Recupero, and Enrico Motta
Subjects: Chatbots, knowledge graphs, human–robot interaction, scholarly data, user experience, virtual assistant, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract: In the last few years, chatbots have become mainstream solutions adopted in a variety of domains for automatizing communication at scale. In the same period, knowledge graphs have attracted significant attention from business and academia as robust and scalable representations of information. In the scientific and academic research domain, they are increasingly used to illustrate the relevant actors (e.g., researchers, institutions), documents (e.g., articles, patents), entities (e.g., concepts, innovations), and other related information. Following the same direction, this paper describes how to integrate conversational agents with knowledge graphs focused on the scholarly domain, a.k.a. Scientific Knowledge Graphs. On top of the proposed architecture, we developed AIDA-Bot, a simple chatbot that leverages a large-scale knowledge graph of scholarly data. AIDA-Bot can answer natural language questions about scientific articles, research concepts, researchers, institutions, and research venues. We have developed four prototypes of AIDA-Bot on Alexa products, web browsers, Telegram clients, and humanoid robots. We performed a user study evaluation with 15 domain experts showing a high level of interest and engagement with the proposed agent.
Published: 2023
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114. Investigating the Origin of TMS-evoked Brain Potentials Using Topographic Analysis

Author: Sulcova, Dominika, Salatino, Adriana, Ivanoiu, Adrian, and Mouraux, André
Published: 2022
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115. Parameters of the gross composition of propolis from Brazilian Meliponini

Author: Regnier, Leonardo, Salatino, Maria-Luiza F., and Salatino, Antonio
Abstract: AbstractPropolis is a resinous and complex bee product containing resin derived from plants, beeswax, pollen and other minor constituents. The present study aimed to determine the parameters of the gross composition of propolis collected by nine stingless bee species from eight different Brazilian localities. The moisture content varied depending on the bee species and localities. Wax content enables us to distinguish between samples of Meliponaand Scaptotrigona, samples of the former containing considerably less wax than samples of the latter genus. The ash content has an inverse trend, with samples of Meliponaand Scaptotrigonahaving high and low ash content, respectively. The results indicated that Meliponaspecies produce geopropolis (propolis containing aggregated soil material), while Scaptotrigonaproduces propolis devoid of soil, with the exception of S. tubiba. Most Meliponaspecies collected sediments with high clay content. The size and color of ash crystals varied, mostly according to the locality of the meliponaries, although differences were observed between samples of the same species, growing in the same meliponary. Mineralogical analysis was relevant to determine that M. flavolineatafrom North Brazil aggregates river-bed soil sediments to the geopropolis.
Published: 2024
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116. How diverse is the chemistry and plant origin of Brazilian propolis?

Author: Salatino, Antonio, Salatino, Maria Luiza Faria, and Negri, Giuseppina
Published: 2021
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117. Modulation of vestibular input by short-term head-down bed rest affects somatosensory perception: implications for space missions

Author: Roberto Gammeri, Adriana Salatino, Maria Pyasik, Emanuele Cirillo, Claudio Zavattaro, Hilary Serra, Lorenzo Pia, Donna R. Roberts, Anna Berti, and Raffaella Ricci
Subjects: vestibular system, sensory attenuation, somatosensory perception, head-down bed rest, tactile perception, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: IntroductionOn Earth, self-produced somatosensory stimuli are typically perceived as less intense than externally generated stimuli of the same intensity, a phenomenon referred to as somatosensory attenuation (SA). Although this phenomenon arises from the integration of multisensory signals, the specific contribution of the vestibular system and the sense of gravity to somatosensory cognition underlying distinction between self-generated and externally generated sensations remains largely unknown. Here, we investigated whether temporary modulation of the gravitational input by head-down tilt bed rest (HDBR)–a well-known Earth-based analog of microgravity—might significantly affect somatosensory perception of self- and externally generated stimuli.MethodsIn this study, 40 healthy participants were tested using short-term HDBR. Participants received a total of 40 non-painful self- and others generated electrical stimuli (20 self- and 20 other-generated stimuli) in an upright and HDBR position while blindfolded. After each stimulus, they were asked to rate the perceived intensity of the stimulation on a Likert scale.ResultsSomatosensory stimulations were perceived as significantly less intense during HDBR compared to upright position, regardless of the agent administering the stimulus. In addition, the magnitude of SA in upright position was negatively correlated with the participants’ somatosensory threshold. Based on the direction of SA in the upright position, participants were divided in two subgroups. In the subgroup experiencing SA, the intensity rating of stimulations generated by others decreased significantly during HDBR, leading to the disappearance of the phenomenon of SA. In the second subgroup, on the other hand, reversed SA was not affected by HDBR.ConclusionModulation of the gravitational input by HDBR produced underestimation of somatosensory stimuli. Furthermore, in participants experiencing SA, the reduction of vestibular inputs by HDBR led to the disappearance of the SA phenomenon. These findings provide new insights into the role of the gravitational input in somatosensory perception and have important implications for astronauts who are exposed to weightlessness during space missions.
Published: 2023
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118. 72 - Intraneural pudendal nerve recording and stimulation in animal models for the closed-loop control of lower urinary tract dysfunction

Author: Alice Giannotti, Sara Lo Vecchio, Laura Salatino, Valentina Paggi, Fabio Bernini, Khatia Gabisonia, Lucia Carlucci, Stefania Musco, Stephanie Lacour, Fabio Anastasio Recchia, Giulio Del Popolo, and Silvestro Micera
Subjects: Diseases of the genitourinary system. Urology, RC870-923
Published: 2023
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119. The Atacama Cosmology Telescope: Mitigating the Impact of Extragalactic Foregrounds for the DR6 Cosmic Microwave Background Lensing Analysis

Author: Niall MacCrann, Blake D. Sherwin, Frank J. Qu, Toshiya Namikawa, Mathew S. Madhavacheril, Irene Abril-Cabezas, Rui An, Jason E. Austermann, Nicholas Battaglia, Elia S. Battistelli, James A. Beall, Boris Bolliet, J. Richard Bond, Hongbo Cai, Erminia Calabrese, William R. Coulton, Omar Darwish, Shannon M. Duff, Adriaan J. Duivenvoorden, Jo Dunkley, Gerrit S. Farren, Simone Ferraro, Joseph E. Golec, Yilun Guan, Dongwon Han, Carlos Hervías-Caimapo, J. Colin Hill, Matt Hilton, Renée Hložek, Johannes Hubmayr, Joshua Kim, Zack Li, Arthur Kosowsky, Thibaut Louis, Jeff McMahon, Gabriela A. Marques, Kavilan Moodley, Sigurd Naess, Michael D. Niemack, Lyman Page, Bruce Partridge, Emmanuel Schaan, Neelima Sehgal, Cristóbal Sifón, Edward J. Wollack, Maria Salatino, Joel N. Ullom, Jeff Van Lanen, Alexander Van Engelen, and Lukas Wenzl
Subjects: Cosmology, Large-scale structure of the universe, Weak gravitational lensing, Cosmic microwave background radiation, Astrophysics, QB460-466
Abstract: We investigate the impact and mitigation of extragalactic foregrounds for the cosmic microwave background (CMB) lensing power spectrum analysis of Atacama Cosmology Telescope (ACT) data release 6 (DR6) data. Two independent microwave sky simulations are used to test a range of mitigation strategies. We demonstrate that finding and then subtracting point sources, finding and then subtracting models of clusters, and using a profile bias-hardened lensing estimator together reduce the fractional biases to well below statistical uncertainties, with the inferred lensing amplitude, A _lens , biased by less than 0.2 σ . We also show that another method where a model for the cosmic infrared background (CIB) contribution is deprojected and high-frequency data from Planck is included has similar performance. Other frequency-cleaned options do not perform as well, either incurring a large noise cost or resulting in biased recovery of the lensing spectrum. In addition to these simulation-based tests, we also present null tests on the ACT DR6 data for sensitivity of our lensing spectrum estimation to differences in foreground levels between the two ACT frequencies used, while nulling the CMB lensing signal. These tests pass whether the nulling is performed at the map or bandpower level. The CIB-deprojected measurement performed on the DR6 data is consistent with our baseline measurement, implying that contamination from the CIB is unlikely to significantly bias the DR6 lensing spectrum. This collection of tests gives confidence that the ACT DR6 lensing measurements and cosmological constraints presented in companion papers to this work are robust to extragalactic foregrounds.
Published: 2024
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120. The Atacama Cosmology Telescope: Millimeter Observations of a Population of Asteroids or: ACTeroids

Author: John Orlowski-Scherer, Ricco C. Venterea, Nicholas Battaglia, Sigurd Naess, Tanay Bhandarkar, Emily Biermann, Erminia Calabrese, Mark Devlin, Jo Dunkley, Carlos Hervías-Caimapo, Patricio A. Gallardo, Matt Hilton, Adam D. Hincks, Kenda Knowles, Yaqiong Li, Jeffrey J McMahon, Michael D. Niemack, Lyman A. Page, Bruce Partridge, Maria Salatino, Jonathan Sievers, Cristóbal Sifón, Suzanne Staggs, Alexander van Engelen, Cristian Vargas, Eve M. Vavagiakis, and Edward J. Wollack
Subjects: Asteroids, Cosmic microwave background radiation, Millimeter astronomy, Astrophysics, QB460-466
Abstract: We present fluxes and light curves for a population of asteroids at millimeter wavelengths, detected by the Atacama Cosmology Telescope (ACT) over 18,000 deg ^2 of the sky using data from 2017 to 2021. We utilize high cadence maps, which can be used in searching for moving objects such as asteroids and trans-Neptunian Objects, as well as for studying transients. We detect 170 asteroids with a signal-to-noise of at least 5 in at least one of the ACT observing bands, which are centered near 90, 150, and 220 GHz. For each asteroid, we compare the ACT measured flux to predicted fluxes from the near-Earth asteroid thermal model fit to WISE data. We confirm previous results that detected a deficit of flux at millimeter wavelengths. Moreover, we report a spectral characteristic to this deficit, such that the flux is relatively lower at 150 and 220 GHz than at 90 GHz. Additionally, we find that the deficit in flux is greater for S-type asteroids than for C-type.
Published: 2024
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121. The Atacama Cosmology Telescope: DR6 Gravitational Lensing Map and Cosmological Parameters

Author: Mathew S. Madhavacheril, Frank J. Qu, Blake D. Sherwin, Niall MacCrann, Yaqiong Li, Irene Abril-Cabezas, Peter A. R. Ade, Simone Aiola, Tommy Alford, Mandana Amiri, Stefania Amodeo, Rui An, Zachary Atkins, Jason E. Austermann, Nicholas Battaglia, Elia Stefano Battistelli, James A. Beall, Rachel Bean, Benjamin Beringue, Tanay Bhandarkar, Emily Biermann, Boris Bolliet, J Richard Bond, Hongbo Cai, Erminia Calabrese, Victoria Calafut, Valentina Capalbo, Felipe Carrero, Anthony Challinor, Grace E. Chesmore, Hsiao-mei Cho, Steve K. Choi, Susan E. Clark, Rodrigo Córdova Rosado, Nicholas F. Cothard, Kevin Coughlin, William Coulton, Kevin T. Crowley, Roohi Dalal, Omar Darwish, Mark J. Devlin, Simon Dicker, Peter Doze, Cody J. Duell, Shannon M. Duff, Adriaan J. Duivenvoorden, Jo Dunkley, Rolando Dünner, Valentina Fanfani, Max Fankhanel, Gerrit Farren, Simone Ferraro, Rodrigo Freundt, Brittany Fuzia, Patricio A. Gallardo, Xavier Garrido, Jahmour Givans, Vera Gluscevic, Joseph E. Golec, Yilun Guan, Kirsten R. Hall, Mark Halpern, Dongwon Han, Ian Harrison, Matthew Hasselfield, Erin Healy, Shawn Henderson, Brandon Hensley, Carlos Hervías-Caimapo, J. Colin Hill, Gene C. Hilton, Matt Hilton, Adam D. Hincks, Renée Hložek, Shuay-Pwu Patty Ho, Zachary B. Huber, Johannes Hubmayr, Kevin M. Huffenberger, John P. Hughes, Kent Irwin, Giovanni Isopi, Hidde T. Jense, Ben Keller, Joshua Kim, Kenda Knowles, Brian J. Koopman, Arthur Kosowsky, Darby Kramer, Aleksandra Kusiak, Adrien La Posta, Alex Lague, Victoria Lakey, Eunseong Lee, Zack Li, Michele Limon, Martine Lokken, Thibaut Louis, Marius Lungu, Amanda MacInnis, Diego Maldonado, Felipe Maldonado, Maya Mallaby-Kay, Gabriela A. Marques, Jeff McMahon, Yogesh Mehta, Felipe Menanteau, Kavilan Moodley, Thomas W. Morris, Tony Mroczkowski, Sigurd Naess, Toshiya Namikawa, Federico Nati, Laura Newburgh, Andrina Nicola, Michael D. Niemack, Michael R. Nolta, John Orlowski-Scherer, Lyman A. Page, Shivam Pandey, Bruce Partridge, Heather Prince, Roberto Puddu, Federico Radiconi, Naomi Robertson, Felipe Rojas, Tai Sakuma, Maria Salatino, Emmanuel Schaan, Benjamin L. Schmitt, Neelima Sehgal, Shabbir Shaikh, Carlos Sierra, Jon Sievers, Cristóbal Sifón, Sara Simon, Rita Sonka, David N. Spergel, Suzanne T. Staggs, Emilie Storer, Eric R. Switzer, Niklas Tampier, Robert Thornton, Hy Trac, Jesse Treu, Carole Tucker, Joel Ullom, Leila R. Vale, Alexander Van Engelen, Jeff Van Lanen, Joshiwa van Marrewijk, Cristian Vargas, Eve M. Vavagiakis, Kasey Wagoner, Yuhan Wang, Lukas Wenzl, Edward J. Wollack, Zhilei Xu, Fernando Zago, and Kaiwen Zheng
Subjects: Cosmology, Observational cosmology, Cosmic microwave background radiation, Large-scale structure of the universe, Cosmological neutrinos, Particle astrophysics, Astrophysics, QB460-466
Abstract: We present cosmological constraints from a gravitational lensing mass map covering 9400 deg ^2 reconstructed from measurements of the cosmic microwave background (CMB) made by the Atacama Cosmology Telescope (ACT) from 2017 to 2021. In combination with measurements of baryon acoustic oscillations and big bang nucleosynthesis, we obtain the clustering amplitude σ _8 = 0.819 ± 0.015 at 1.8% precision, ${S}_{8}\equiv {\sigma }_{8}{({{\rm{\Omega }}}_{{\rm{m}}}/0.3)}^{0.5}=0.840\pm 0.028$ , and the Hubble constant H _0 = (68.3 ± 1.1) km s ^−1 Mpc ^−1 at 1.6% precision. A joint constraint with Planck CMB lensing yields σ _8 = 0.812 ± 0.013, ${S}_{8}\equiv {\sigma }_{8}{({{\rm{\Omega }}}_{{\rm{m}}}/0.3)}^{0.5}=0.831\pm 0.023$ , and H _0 = (68.1 ± 1.0) km s ^−1 Mpc ^−1 . These measurements agree with ΛCDM extrapolations from the CMB anisotropies measured by Planck. We revisit constraints from the KiDS, DES, and HSC galaxy surveys with a uniform set of assumptions and find that S _8 from all three are lower than that from ACT+Planck lensing by levels ranging from 1.7 σ to 2.1 σ . This motivates further measurements and comparison, not just between the CMB anisotropies and galaxy lensing but also between CMB lensing probing z ∼ 0.5–5 on mostly linear scales and galaxy lensing at z ∼ 0.5 on smaller scales. We combine with CMB anisotropies to constrain extensions of ΛCDM, limiting neutrino masses to ∑ m _ν < 0.13 eV (95% c.l.), for example. We describe the mass map and related data products that will enable a wide array of cross-correlation science. Our results provide independent confirmation that the universe is spatially flat, conforms with general relativity, and is described remarkably well by the ΛCDM model, while paving a promising path for neutrino physics with lensing from upcoming ground-based CMB surveys.
Published: 2024
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122. The Atacama Cosmology Telescope: A Measurement of the DR6 CMB Lensing Power Spectrum and Its Implications for Structure Growth

Author: Frank J. Qu, Blake D. Sherwin, Mathew S. Madhavacheril, Dongwon Han, Kevin T. Crowley, Irene Abril-Cabezas, Peter A. R. Ade, Simone Aiola, Tommy Alford, Mandana Amiri, Stefania Amodeo, Rui An, Zachary Atkins, Jason E. Austermann, Nicholas Battaglia, Elia Stefano Battistelli, James A. Beall, Rachel Bean, Benjamin Beringue, Tanay Bhandarkar, Emily Biermann, Boris Bolliet, J Richard Bond, Hongbo Cai, Erminia Calabrese, Victoria Calafut, Valentina Capalbo, Felipe Carrero, Julien Carron, Anthony Challinor, Grace E. Chesmore, Hsiao-mei Cho, Steve K. Choi, Susan E. Clark, Rodrigo Córdova Rosado, Nicholas F. Cothard, Kevin Coughlin, William Coulton, Roohi Dalal, Omar Darwish, Mark J. Devlin, Simon Dicker, Peter Doze, Cody J. Duell, Shannon M. Duff, Adriaan J. Duivenvoorden, Jo Dunkley, Rolando Dünner, Valentina Fanfani, Max Fankhanel, Gerrit Farren, Simone Ferraro, Rodrigo Freundt, Brittany Fuzia, Patricio A. Gallardo, Xavier Garrido, Vera Gluscevic, Joseph E. Golec, Yilun Guan, Mark Halpern, Ian Harrison, Matthew Hasselfield, Erin Healy, Shawn Henderson, Brandon Hensley, Carlos Hervías-Caimapo, J. Colin Hill, Gene C. Hilton, Matt Hilton, Adam D. Hincks, Renée Hložek, Shuay-Pwu Patty Ho, Zachary B. Huber, Johannes Hubmayr, Kevin M. Huffenberger, John P. Hughes, Kent Irwin, Giovanni Isopi, Hidde T. Jense, Ben Keller, Joshua Kim, Kenda Knowles, Brian J. Koopman, Arthur Kosowsky, Darby Kramer, Aleksandra Kusiak, Adrien La Posta, Alex Lague, Victoria Lakey, Eunseong Lee, Zack Li, Yaqiong Li, Michele Limon, Martine Lokken, Thibaut Louis, Marius Lungu, Niall MacCrann, Amanda MacInnis, Diego Maldonado, Felipe Maldonado, Maya Mallaby-Kay, Gabriela A. Marques, Jeff McMahon, Yogesh Mehta, Felipe Menanteau, Kavilan Moodley, Thomas W. Morris, Tony Mroczkowski, Sigurd Naess, Toshiya Namikawa, Federico Nati, Laura Newburgh, Andrina Nicola, Michael D. Niemack, Michael R. Nolta, John Orlowski-Scherer, Lyman A. Page, Shivam Pandey, Bruce Partridge, Heather Prince, Roberto Puddu, Federico Radiconi, Naomi Robertson, Felipe Rojas, Tai Sakuma, Maria Salatino, Emmanuel Schaan, Benjamin L. Schmitt, Neelima Sehgal, Shabbir Shaikh, Carlos Sierra, Jon Sievers, Cristóbal Sifón, Sara Simon, Rita Sonka, David N. Spergel, Suzanne T. Staggs, Emilie Storer, Eric R. Switzer, Niklas Tampier, Robert Thornton, Hy Trac, Jesse Treu, Carole Tucker, Joel Ullom, Leila R. Vale, Alexander Van Engelen, Jeff Van Lanen, Joshiwa van Marrewijk, Cristian Vargas, Eve M. Vavagiakis, Kasey Wagoner, Yuhan Wang, Lukas Wenzl, Edward J. Wollack, Zhilei Xu, Fernando Zago, and Kaiwen Zheng
Subjects: Cosmological parameters, Cosmological parameters from large-scale structure, Astrophysics, QB460-466
Abstract: We present new measurements of cosmic microwave background (CMB) lensing over 9400 deg ^2 of the sky. These lensing measurements are derived from the Atacama Cosmology Telescope (ACT) Data Release 6 (DR6) CMB data set, which consists of five seasons of ACT CMB temperature and polarization observations. We determine the amplitude of the CMB lensing power spectrum at 2.3% precision (43 σ significance) using a novel pipeline that minimizes sensitivity to foregrounds and to noise properties. To ensure that our results are robust, we analyze an extensive set of null tests, consistency tests, and systematic error estimates and employ a blinded analysis framework. Our CMB lensing power spectrum measurement provides constraints on the amplitude of cosmic structure that do not depend on Planck or galaxy survey data, thus giving independent information about large-scale structure growth and potential tensions in structure measurements. The baseline spectrum is well fit by a lensing amplitude of A _lens = 1.013 ± 0.023 relative to the Planck 2018 CMB power spectra best-fit ΛCDM model and A _lens = 1.005 ± 0.023 relative to the ACT DR4 + WMAP best-fit model. From our lensing power spectrum measurement, we derive constraints on the parameter combination ${S}_{8}^{\mathrm{CMBL}}\equiv {\sigma }_{8}{\left({{\rm{\Omega }}}_{m}/0.3\right)}^{0.25}$ of ${S}_{8}^{\mathrm{CMBL}}=0.818\pm 0.022$ from ACT DR6 CMB lensing alone and ${S}_{8}^{\mathrm{CMBL}}=0.813\pm 0.018$ when combining ACT DR6 and Planck NPIPE CMB lensing power spectra. These results are in excellent agreement with ΛCDM model constraints from Planck or ACT DR4 + WMAP CMB power spectrum measurements. Our lensing measurements from redshifts z ∼ 0.5–5 are thus fully consistent with ΛCDM structure growth predictions based on CMB anisotropies probing primarily z ∼ 1100. We find no evidence for a suppression of the amplitude of cosmic structure at low redshifts.
Published: 2024
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123. Correction: Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells

Author: Balañá, Maria Eugenia, Labriola, Leticia, Salatino, Mariana, Movsichoff, Federico, Peters, Giselle, Charreau, Eduardo H., and Elizalde, Patricia V.
Published: 2023
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124. Improvement of Impulsivity and Decision Making by Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in a Patient with Gambling Disorder

Author: Salatino, Adriana, Miccolis, Roberta, Gammeri, Roberto, Ninghetto, Marco, Belli, Francesco, Nobili, Marcello, Mouraux, André, and Ricci, Raffaella
Published: 2022
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125. QUBIC: Exploring the primordial Universe with the Q\&U Bolometric Interferometer

Author: Mennella, Aniello, Ade, Peter, Amico, Giorgio, Auguste, Didier, Aumont, Jonathan, Banfi, Stefano, Barbaràn, Gustavo, Battaglia, Paola, Battistelli, Elia, Baù, Alessandro, Bélier, Benoit, Bennett, David G., Bergé, Laurent, Bernard, Jean Philippe, Bersanelli, Marco, Sazy, Marie Anne Bigot, Bleurvacq, Nathat, Bonaparte, Juan, Bonis, Julien, Bunn, Emory F., Burke, David, Buzi, Daniele, Buzzelli, Alessandro, Cavaliere, Francesco, Chanial, Pierre, Chapron, Claude, Charlassier, Romain, Columbro, Fabio, Coppi, Gabriele, Coppolecchia, Alessandro, D'Agostino, Rocco, D'Alessandro, Giuseppe, De Bernardis, Paolo, De Gasperis, Giancarlo, De Leo, Michele, De Petris, Marco, Di Donato, Andres, Dumoulin, Louis, Etchegoyen, Alberto, Fasciszewski, Adrián, Franceschet, Cristian, Lerena, Martin Miguel Gamboa, Garcia, Beatriz, Garrido, Xavier, Gaspard, Michel, Gault, Amanda, Gayer, Donnacha, Gervasi, Massimo, Giard, Martin, Héraud, Yannick Giraud, Berisso, Mariano Gómez, González, Manuel, Gradziel, Marcin, Grandsire, Laurent, Guerard, Eric, Hamilton, Jean Christophe, Harari, Diego, Haynes, Vic, Versillé, Sophie Henrot, Hoang, Duc Thuong, Holtzer, Nicolas, Incardona, Federico, Jules, Eric, Kaplan, Jean, Korotkov, Andrei, Kristukat, Christian, Lamagna, Luca, Loucatos, Soutiris, Lowitz, Amy, Lukovic, Vladimir, Thibault, Louis, Luterstein, Raùl Horacio, Maffei, Bruno, Marnieros, Stefanos, Masi, Silvia, Mattei, Angelo, May, Andrew, McCulloch, Mark, Medina, Maria C., Mele, Lorenzo, Melhuish, Simon J., Montier, Ludovic, Mousset, Louise, Mundo, Luis Mariano, Murphy, John Anthony, Murphy, James, O'Sullivan, Creidhe, Olivieri, Emiliano, Paiella, Alessandro, Pajot, Francois, Passerini, Andrea, Pastoriza, Hernan, Pelosi, Alessandro, Perbost, Camille, Perciballi, Maurizio, Pezzotta, Federico, Piacentini, Francesco, Piat, Michel, Piccirillo, Lucio, Pisano, Giampaolo, Polenta, Gianluca, Prêle, Damien, Puddu, Roberto, Rambaud, Damien, Ringegni, Pablo, Romero, Gustavo E., Salatino, Maria, Schillaci, Alessandro, Scóccola, Claudia G., Scully, Stephen P., Spinelli, Sebastiano, Stolpovskiy, Michail, Suarez, Federico, Stankowiak, Guillaume, Tartari, Andrea, Thermeau, Jean Pierre, Timbie, Peter, Tomasi, Maurizio, Torchinsky, Steve A., Tristram, Mathieu, Tucker, Gregory S., Tucker, Carole E., Vanneste, Sylvain, Viganò, Daniele, Vittorio, Nicola, Voisin, Fabrice, Watson, Robert, Wicek, Francois, Zannoni, Mario, and Zullo, Antonio
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: In this paper we describe QUBIC, an experiment that will observe the polarized microwave sky with a novel approach, which combines the sensitivity of state-of-the art bolometric detectors with the systematic effects control typical of interferometers. QUBIC unique features are the so-called "self-calibration", a technique that allows us to clean the measured data from instrumental effects, and its spectral imaging power, i.e. the ability to separate the signal in various sub-bands within each frequency band. QUBIC will observe the sky in two main frequency bands: 150 GHz and 220 GHz. A technological demonstrator is currently under testing and will be deployed in Argentina during 2019, while the final instrument is expected to be installed during 2020., Comment: Proceedings of the 2018 ICNFP conference, Crete. Published by Universe arXiv admin note: text overlap with arXiv:1801.03730
Published: 2018
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126. Thermal architecture for the QUBIC cryogenic receiver

Author: May, A. J., Chapron, C., Coppi, G., D'Alessandro, G., de Bernardis, P., Masi, S., Melhuish, S., Piat, M., Piccirillo, L., Schillaci, A., Thermeau, J. -P., Ade, P., Amico, G., Auguste, D., Aumont, J., Banfi, S., Barbara, G., Battaglia, P., Battistelli, E., Bau, A., Belier, B., Bennett, D., Berge, L., Bernard, J. -Ph., Bersanelli, M., Bigot-Sazy, M. -A., Bleurvacq, N., Bonaparte, J., Bonis, J., Bordier, G., Breelle, E., Bunn, E., Burke, D., Buzi, D., Buzzelli, A., Cavaliere, F., Chanial, P., Charlassier, R., Columbro, F., Coppolecchia, A., Couchot, F., D'Agostino, R., De Gasperis, G., De Leo, M., De Petris, M., Di Donato, A., Dumoulin, L., Etchegoyen, A., Fasciszewski, A., Franceschet, C., Lerena, M. M. Gamboa, Garcia, B., Garrido, X., Gaspard, M., Gault, A., Gayer, D., Gervasi, M., Giard, M., Giraud-Heraud, Y., Berisso, M. Gomez, Gonzalez, M., Gradziel, M., Grandsire, L., Guerrard, E., Hamilton, J. -Ch., Harari, D., Haynes, V., Henrot-Versille, S., Hoang, D. T., Incardona, F., Jules, E., Kaplan, J., Korotkov, A., Kristukat, C., Lamagna, L., Loucatos, S., Louis, T., Lowitz, A., Lukovic, V., Luterstein, R., Maffei, B., Marnieros, S., Mattei, A., McCulloch, M. A., Medina, M. C., Mele, L., Mennella, A., Montier, L., Mundo, L. M., Murphy, J. A., Murphy, J. D., O'Sullivan, C., Olivieri, E., Paiella, A., Pajot, F., Passerini, A., Pastoriza, H., Pelosi, A., Perbost, C., Perdereau, O., Pezzotta, F., Piacentini, F., Pisano, G., Polenta, G., Prele, D., Puddu, R., Rambaud, D., Ringegni, P., Romero, G. E., Salatino, M., Scoccola, C. G., Scully, S., Spinelli, S., Stolpovskiy, M., Suarez, F., Tartari, A., Timbie, P., Torchinsky, S. A., Tristram, M., Truongcanh, V., Tucker, C., Tucker, G., Vanneste, S., Vigano, D., Vittorio, N., Voisin, F., Watson, B., Wicek, F., Zannoni, M., and Zullo, A.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract: QUBIC, the QU Bolometric Interferometer for Cosmology, is a novel forthcoming instrument to measure the B-mode polarization anisotropy of the Cosmic Microwave Background. The detection of the B-mode signal will be extremely challenging; QUBIC has been designed to address this with a novel approach, namely bolometric interferometry. The receiver cryostat is exceptionally large and cools complex optical and detector stages to 40 K, 4 K, 1 K and 350 mK using two pulse tube coolers, a novel 4He sorption cooler and a double-stage 3He/4He sorption cooler. We discuss the thermal and mechanical design of the cryostat, modelling and thermal analysis, and laboratory cryogenic testing.
Published: 2018

127. Development of Calibration Strategies for the Simons Observatory

Author: Bryan, Sean A., Simon, Sara M., Gerbino, Martina, Teply}, Grant, Ali, Aamir, Chinone, Yuji, Crowley, Kevin, Fabbian, Giulio, Gallardo, Patricio A., Goeckner-Wald, Neil, Keating, Brian, Koopman, Brian, Kusaka, Akito, Matsuda, Frederick, Mauskopf, Philip, McMahon, Jeff, Nati, Federico, Puglisi, Giuseppe, Reichardt, Christian L, Salatino, Maria, Xu, Zhilei, and Zhu, Ningfeng
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The Simons Observatory (SO) is a set of cosmic microwave background instruments that will be deployed in the Atacama Desert in Chile. The key science goals include setting new constraints on cosmic inflation, measuring large scale structure with gravitational lensing, and constraining neutrino masses. Meeting these science goals with SO requires high sensitivity and improved calibration techniques. In this paper, we highlight a few of the most important instrument calibrations, including spectral response, gain stability, and polarization angle calibrations. We present their requirements for SO and experimental techniques that can be employed to reach those requirements., Comment: 13 pages, 4 figures, SPIE Astronomical Telescopes and Instrumentation 2018
Published: 2018
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128. Feedhorn development and scalability for Simons Observatory and beyond

Author: Simon, Sara M., Golec, Joseph E., Ali, Aamir, Austermann, Jason, Beall, James A., Bruno, Sarah Marie M., Choi, Steve K., Crowley, Kevin T., Dicker, Simon, Dober, Bradley, Duff, Shannon M., Healy, Erin, Hill, Charles A., Ho, Shuay-Pwu Patty, Hubmayr, Johannes, Li, Yaqiong, Lungu, Marius, McMahon, Jeff, Orlowski-Scherer, John, Salatino, Maria, Staggs, Suzanne, Wollack, Edward J., Xu, Zhilei, and Zhu, Ningfeng
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Simons Observatory (SO) will measure the cosmic microwave background (CMB) in both temperature and polarization over a wide range of angular scales and frequencies from 27-270 GHz with unprecedented sensitivity. One technology for coupling light onto the $\sim$50 detector wafers that SO will field is spline-profiled feedhorns, which offer tunability between coupling efficiency and control of beam polarization leakage effects. We will present efforts to scale up feedhorn production for SO and their viability for future CMB experiments, including direct-machining metal feedhorn arrays and laser machining stacked Si arrays.
Published: 2018
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129. Studies of Systematic Uncertainties for Simons Observatory: Detector Array Effects

Author: Crowley, Kevin T., Simon, Sara M., Silva-Feaver, Max, Goeckner-Wald, Neil, Ali, Aamir, Austermann, Jason, Brown, Michael L., Chinone, Yuji, Cukierman, Ari, Dober, Bradley, Duff, Shannon M., Dunkley, Jo, Errard, Josquin, Fabbian, Giulio, Gallardo, Patricio A., Ho, Shuay-Pwu Patty, Hubmayr, Johannes, Keating, Brian, Kusaka, Akito, McCallum, Nialh, McMahon, Jeff, Nati, Federico, Niemack, Michael D., Puglisi, Giuseppe, Rao, Mayuri Sathyanarayana, Reichardt, Christian L., Salatino, Maria, Siritanasak, Praween, Staggs, Suzanne, Suzuki, Aritoki, Teply, Grant, Thomas, Daniel B., Ullom, Joel N., Vergès, Clara, Vissers, Michael R., Westbrook, Benjamin, Wollack, Edward J., Xu, Zhilei, and Zhu, Ningfeng
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: In this proceeding, we present studies of instrumental systematic effects for the Simons Obsevatory (SO) that are associated with the detector system and its interaction with the full SO experimental systems. SO will measure the Cosmic Microwave Background (CMB) temperature and polarization anisotropies over a wide range of angular scales in six bands with bandcenters spanning from 27 GHz to 270 GHz. We explore effects including intensity-to-polarization leakage due to coupling optics, bolometer nonlinearity, uncalibrated gain variations of bolometers, and readout crosstalk. We model the level of signal contamination, discuss proposed mitigation schemes, and present instrument requirements to inform the design of SO and future CMB projects., Comment: Proceeding from SPIE Astronomical Telescopes+Instrumentation 2018 (27 pages, 13 figures) v2: Added HEALPix reference
Published: 2018
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130. Simons Observatory Large Aperture Telescope Receiver Design Overview

Author: Zhu, Ningfeng, Orlowski-Scherer, John L., Xu, Zhilei, Ali, Aamir, Arnold, Kam S., Ashton, Peter C., Coppi, Gabriele, Devlin, Mark J., Dicker, Simon, Galitzki, Nicholas, Gallardo, Patricio A., Henderson, Shawn W., Ho, Shuay-Pwu Patty, Hubmayr, Johannes, Keating, Brian, Lee, Adrian T., Limon, Michele, Lungu, Marius, Mauskopf, Philip D., May, Andrew J., McMahon, Jeff, Niemack, Michael D., Piccirillo, Lucio, Puglisi, Giuseppe, Rao, Mayuri Sathyanarayana, Salatino, Maria, Silva-Feaver, Max, Simon, Sara M., Staggs, Suzanne, Thornton, Robert, Ullom, Joel N., Vavagiakis, Eve M., Westbrook, Benjamin, and Wollack, Edward J.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Simons Observatory (SO) will make precision temperature and polarization measurements of the cosmic microwave background (CMB) using a series of telescopes which will cover angular scales between one arcminute and tens of degrees and sample frequencies between 27 and 270 GHz. Here we present the current design of the large aperture telescope receiver (LATR), a 2.4 m diameter cryostat that will be mounted on the SO 6 m telescope and will be the largest CMB receiver to date. The cryostat size was chosen to take advantage of the large focal plane area having high Strehl ratios, which is inherent to the Cross-Dragone telescope design. The LATR will be able to accommodate thirteen optics tubes, each having a 36 cm diameter aperture and illuminating several thousand transition-edge sensor (TES) bolometers. This set of equipment will provide an opportunity to make measurements with unparalleled sensitivity. However, the size and complexity of the LATR also pose numerous technical challenges. In the following paper, we present the design of the LATR and include how we address these challenges. The solutions we develop in the process of designing the LATR will be informative for the general CMB community, and for future CMB experiments like CMB-S4.
Published: 2018

131. Cooldown Strategies and Transient Thermal Simulations for the Simons Observatory

Author: Coppi, Gabriele, Xu, Zhilei, Ali, Aamir, Devlin, Mark J., Dicker, Simon, Galitzki, Nicholas, Gallardo, Patricio A., Keating, Brian, Limon, Michele, Longu, Marius, May, Andrew J., McMahon, Jeff, Niemack, Michael D., Orlowski-Scherer, Jack L., Piccirillo, Lucio, Puglisi, Giuseppe, Salatino, Maria, Simon, Sara M., Teply, Grant, Thornton, Robert, Vavagiakis, Eve M., and Zhu, Ningfeng
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The Simons Observatory (SO) will provide precision polarimetry of the cosmic microwave background (CMB) using a series of telescopes which will cover angular scales from arc-minutes to tens of degrees, contain over 60,000 detectors, and observe in frequency bands between 27 GHz and 270 GHz. SO will consist of a six-meter-aperture telescope initially coupled to ~35,000 detectors along with an array of 0.5m aperture refractive cameras, coupled to an additional 30,000+ detectors. The large aperture telescope receiver (LATR) is coupled to a six-meter crossed Dragone telescope and will be 2.4m in diameter, weigh over 3 tons, and have five cryogenic stages (80 K, 40 K, 4 K, 1 K and 100 mK). The LATR is coupled to the telescope via 13 independent optics tubes containing cryogenic optical elements and detectors. The cryostat will be cooled by by two Cryomech PT90 (80 K) and three Cryomech PT420 (40 K and 4 K) pulse tube cryocoolers, with cooling of the 1 K and 100 mK stages by a commercial dilution refrigerator system. The second component, the small aperture telescope (SAT), is a single optics tube refractive cameras of 42cm diameter. Cooling of the SAT stages will be provided by two Cryomech PT420, one of which is dedicated to the dilution refrigeration system which will cool the focal plane to 100 mK. SO will deploy a total of three SATs. In order to estimate the cool down time of the camera systems given their size and complexity, a finite difference code based on an implicit solver has been written to simulate the transient thermal behavior of both cryostats. The result from the simulations presented here predict a 35 day cool down for the LATR. The simulations suggest additional heat switches between stages would be effective in distribution cool down power and reducing the time it takes for the LATR to cool. The SAT is predicted to cool down in one week, which meets the SO design goals.
Published: 2018
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132. Studies of Systematic Uncertainties for Simons Observatory: Polarization Modulator Related Effects

Author: Salatino, Maria, Lashner, Jacob, Gerbino, Martina, Simon, Sara M., Didier, Joy, Ali, Aamir, Ashton, Peter C., Bryan, Sean, Chinone, Yuji, Coughlin, Kevin, Crowley, Kevin T., Fabbian, Giulio, Galitzki, Nicholas, Goeckner-Wald, Neil, Golec, Joseph E., Gudmundsson, Jon E., Hill, Charles A., Keating, Brian, Kusaka, Akito, Lee, Adrian T., McMahon, Jeffrey, Miller, Amber D., Puglisi, Giuseppe, Reichardt, Christian L., Teply, Grant, Xu, Zhilei, and Zhu, Ningfeng
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The Simons Observatory (SO) will observe the temperature and polarization anisotropies of the cosmic microwave background (CMB) over a wide range of frequencies (27 to 270 GHz) and angular scales by using both small (0.5 m) and large (6 m) aperture telescopes. The SO small aperture telescopes will target degree angular scales where the primordial B-mode polarization signal is expected to peak. The incoming polarization signal of the small aperture telescopes will be modulated by a cryogenic, continuously-rotating half-wave plate (CRHWP) to mitigate systematic effects arising from slowly varying noise and detector pair-differencing. In this paper, we present an assessment of some systematic effects arising from using a CRHWP in the SO small aperture systems. We focus on systematic effects associated with structural properties of the HWP and effects arising when operating a HWP, including the amplitude of the HWP synchronous signal (HWPSS), and I -> P (intensity to polarization) leakage that arises from detector non-linearity in the presence of a large HWPSS. We demonstrate our ability to simulate the impact of the aforementioned systematic effects in the time domain. This important step will inform mitigation strategies and design decisions to ensure that SO will meet its science goals., Comment: 22 pages, 10 figures. Submitted to the Proceedings of SPIE: Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy IX
Published: 2018

133. The Simons Observatory: Science goals and forecasts

Author: The Simons Observatory Collaboration, Ade, Peter, Aguirre, James, Ahmed, Zeeshan, Aiola, Simone, Ali, Aamir, Alonso, David, Alvarez, Marcelo A., Arnold, Kam, Ashton, Peter, Austermann, Jason, Awan, Humna, Baccigalupi, Carlo, Baildon, Taylor, Barron, Darcy, Battaglia, Nick, Battye, Richard, Baxter, Eric, Bazarko, Andrew, Beall, James A., Bean, Rachel, Beck, Dominic, Beckman, Shawn, Beringue, Benjamin, Bianchini, Federico, Boada, Steven, Boettger, David, Bond, J. Richard, Borrill, Julian, Brown, Michael L., Bruno, Sarah Marie, Bryan, Sean, Calabrese, Erminia, Calafut, Victoria, Calisse, Paolo, Carron, Julien, Challinor, Anthony, Chesmore, Grace, Chinone, Yuji, Chluba, Jens, Cho, Hsiao-Mei Sherry, Choi, Steve, Coppi, Gabriele, Cothard, Nicholas F., Coughlin, Kevin, Crichton, Devin, Crowley, Kevin D., Crowley, Kevin T., Cukierman, Ari, D'Ewart, John M., Dünner, Rolando, de Haan, Tijmen, Devlin, Mark, Dicker, Simon, Didier, Joy, Dobbs, Matt, Dober, Bradley, Duell, Cody J., Duff, Shannon, Duivenvoorden, Adri, Dunkley, Jo, Dusatko, John, Errard, Josquin, Fabbian, Giulio, Feeney, Stephen, Ferraro, Simone, Fluxà, Pedro, Freese, Katherine, Frisch, Josef C., Frolov, Andrei, Fuller, George, Fuzia, Brittany, Galitzki, Nicholas, Gallardo, Patricio A., Ghersi, Jose Tomas Galvez, Gao, Jiansong, Gawiser, Eric, Gerbino, Martina, Gluscevic, Vera, Goeckner-Wald, Neil, Golec, Joseph, Gordon, Sam, Gralla, Megan, Green, Daniel, Grigorian, Arpi, Groh, John, Groppi, Chris, Guan, Yilun, Gudmundsson, Jon E., Han, Dongwon, Hargrave, Peter, Hasegawa, Masaya, Hasselfield, Matthew, Hattori, Makoto, Haynes, Victor, Hazumi, Masashi, He, Yizhou, Healy, Erin, Henderson, Shawn W., Hervias-Caimapo, Carlos, Hill, Charles A., Hill, J. Colin, Hilton, Gene, Hilton, Matt, Hincks, Adam D., Hinshaw, Gary, Hložek, Renée, Ho, Shirley, Ho, Shuay-Pwu Patty, Howe, Logan, Huang, Zhiqi, Hubmayr, Johannes, Huffenberger, Kevin, Hughes, John P., Ijjas, Anna, Ikape, Margaret, Irwin, Kent, Jaffe, Andrew H., Jain, Bhuvnesh, Jeong, Oliver, Kaneko, Daisuke, Karpel, Ethan D., Katayama, Nobuhiko, Keating, Brian, Kernasovskiy, Sarah S., Keskitalo, Reijo, Kisner, Theodore, Kiuchi, Kenji, Klein, Jeff, Knowles, Kenda, Koopman, Brian, Kosowsky, Arthur, Krachmalnicoff, Nicoletta, Kuenstner, Stephen E., Kuo, Chao-Lin, Kusaka, Akito, Lashner, Jacob, Lee, Adrian, Lee, Eunseong, Leon, David, Leung, Jason S. -Y., Lewis, Antony, Li, Yaqiong, Li, Zack, Limon, Michele, Linder, Eric, Lopez-Caraballo, Carlos, Louis, Thibaut, Lowry, Lindsay, Lungu, Marius, Madhavacheril, Mathew, Mak, Daisy, Maldonado, Felipe, Mani, Hamdi, Mates, Ben, Matsuda, Frederick, Maurin, Loïc, Mauskopf, Phil, May, Andrew, McCallum, Nialh, McKenney, Chris, McMahon, Jeff, Meerburg, P. Daniel, Meyers, Joel, Miller, Amber, Mirmelstein, Mark, Moodley, Kavilan, Munchmeyer, Moritz, Munson, Charles, Naess, Sigurd, Nati, Federico, Navaroli, Martin, Newburgh, Laura, Nguyen, Ho Nam, Niemack, Michael, Nishino, Haruki, Orlowski-Scherer, John, Page, Lyman, Partridge, Bruce, Peloton, Julien, Perrotta, Francesca, Piccirillo, Lucio, Pisano, Giampaolo, Poletti, Davide, Puddu, Roberto, Puglisi, Giuseppe, Raum, Chris, Reichardt, Christian L., Remazeilles, Mathieu, Rephaeli, Yoel, Riechers, Dominik, Rojas, Felipe, Roy, Anirban, Sadeh, Sharon, Sakurai, Yuki, Salatino, Maria, Rao, Mayuri Sathyanarayana, Schaan, Emmanuel, Schmittfull, Marcel, Sehgal, Neelima, Seibert, Joseph, Seljak, Uros, Sherwin, Blake, Shimon, Meir, Sierra, Carlos, Sievers, Jonathan, Sikhosana, Precious, Silva-Feaver, Maximiliano, Simon, Sara M., Sinclair, Adrian, Siritanasak, Praween, Smith, Kendrick, Smith, Stephen R., Spergel, David, Staggs, Suzanne T., Stein, George, Stevens, Jason R., Stompor, Radek, Suzuki, Aritoki, Tajima, Osamu, Takakura, Satoru, Teply, Grant, Thomas, Daniel B., Thorne, Ben, Thornton, Robert, Trac, Hy, Tsai, Calvin, Tucker, Carole, Ullom, Joel, Vagnozzi, Sunny, van Engelen, Alexander, Van Lanen, Jeff, Van Winkle, Daniel D., Vavagiakis, Eve M., Vergès, Clara, Vissers, Michael, Wagoner, Kasey, Walker, Samantha, Ward, Jon, Westbrook, Ben, Whitehorn, Nathan, Williams, Jason, Williams, Joel, Wollack, Edward J., Xu, Zhilei, Yu, Byeonghee, Yu, Cyndia, Zago, Fernando, Zhang, Hezi, and Zhu, Ningfeng
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The Simons Observatory (SO) is a new cosmic microwave background experiment being built on Cerro Toco in Chile, due to begin observations in the early 2020s. We describe the scientific goals of the experiment, motivate the design, and forecast its performance. SO will measure the temperature and polarization anisotropy of the cosmic microwave background in six frequency bands: 27, 39, 93, 145, 225 and 280 GHz. The initial configuration of SO will have three small-aperture 0.5-m telescopes (SATs) and one large-aperture 6-m telescope (LAT), with a total of 60,000 cryogenic bolometers. Our key science goals are to characterize the primordial perturbations, measure the number of relativistic species and the mass of neutrinos, test for deviations from a cosmological constant, improve our understanding of galaxy evolution, and constrain the duration of reionization. The SATs will target the largest angular scales observable from Chile, mapping ~10% of the sky to a white noise level of 2 $\mu$K-arcmin in combined 93 and 145 GHz bands, to measure the primordial tensor-to-scalar ratio, $r$, at a target level of $\sigma(r)=0.003$. The LAT will map ~40% of the sky at arcminute angular resolution to an expected white noise level of 6 $\mu$K-arcmin in combined 93 and 145 GHz bands, overlapping with the majority of the LSST sky region and partially with DESI. With up to an order of magnitude lower polarization noise than maps from the Planck satellite, the high-resolution sky maps will constrain cosmological parameters derived from the damping tail, gravitational lensing of the microwave background, the primordial bispectrum, and the thermal and kinematic Sunyaev-Zel'dovich effects, and will aid in delensing the large-angle polarization signal to measure the tensor-to-scalar ratio. The survey will also provide a legacy catalog of 16,000 galaxy clusters and more than 20,000 extragalactic sources., Comment: This paper presents an overview of the Simons Observatory science goals, details about the instrument will be presented in a companion paper. The author contribution to this paper is available at https://simonsobservatory.org/publications.php (Abstract abridged) -- matching version published in JCAP
Published: 2018
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134. Simons Observatory large aperture receiver simulation overview

Author: Orlowski-Scherer, John L., Zhu, Ningfeng, Xu, Zhilei, Ali, Aamir, Arnold, Kam S., Ashton, Peter C., Coppi, Gabriele, Devlin, Mark, Dicker, Simon, Galitzki, Nicholas, Gallardo, Patricio A., Keating, Brian, Lee, Adrian T., Limon, Michele, Lungu, Marius, May, Andrew, McMahon, Jeff, Niemack, Michael D., Piccirillo, Lucio, Puglisi, Giuseppe, Salatino, Maria, Silva-Feaver, Max, Simon, Sara M., Thornton, Robert, and Vavagiakis, Eve M.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Simons Observatory (SO) will make precision temperature and polarization measurements of the cosmic microwave background (CMB) using a series of telescopes which will cover angular scales between one arcminute and tens of degrees, contain over 60,000 detectors, and sample frequencies between 27 and 270 GHz. SO will consist of a six-meter-aperture telescope coupled to over 30,000 detectors along with an array of half-meter aperture refractive cameras, which together couple to an additional 30,000+ detectors. SO will measure fundamental cosmological parameters of our universe, find high redshift clusters via the Sunyaev-Zeldovich effect, constrain properties of neutrinos, and seek signatures of dark matter through gravitational lensing. In this paper we will present results of the simulations of the SO large aperture telescope receiver (LATR). We will show details of simulations performed to ensure the structural integrity and thermal performance of our receiver, as well as will present the results of finite element analyses (FEA) of designs for the structural support system. Additionally, a full thermal model for the LATR will be described. The model will be used to ensure we meet our design requirements. Finally, we will present the results of FEA used to identify the primary vibrational modes, and planned methods for suppressing these modes. Design solutions to each of these problems that have been informed by simulation will be presented., Comment: 14 pages, 10 figures, Proceedings of SPIE
Published: 2018
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135. Studies of Systematic Uncertainties for Simons Observatory: Optical Effects and Sensitivity Considerations

Author: Gallardo, Patricio A., Gudmundsson, Jon, Koopman, Brian J., Matsuda, Frederick T., Simon, Sara M., Ali, Aamir, Bryan, Sean, Chinone, Yuji, Coppi, Gabriele, Cothard, Nicholas, Devlin, Mark J., Dicker, Simon, Fabbian, Giulio, Galitzki, Nicholas, Hill, Charles A., Keating, Brian, Kusaka, Akito, Lashner, Jacob, Lee, Adrian T., Limon, Michele, Mauskopf, Philip D., McMahon, Jeff, Nati, Federico, Niemack, Michael D., Orlowski-Scherer, John L., Parshley, Stephen C., Puglisi, Giuseppe, Reichardt, Christian L, Salatino, Maria, Staggs, Suzanne, Suzuki, Aritoki, Vavagiakis, Eve M., Wollack, Edward J., Xu, Zhilei, and Zhu, Ningfeng
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract: The Simons Observatory (SO) is a new experiment that aims to measure the cosmic microwave background (CMB) in temperature and polarization. SO will measure the polarized sky over a large range of microwave frequencies and angular scales using a combination of small ($\sim0.5 \, \rm m$) and large ($\sim 6\, \rm m $) aperture telescopes and will be located in the Atacama Desert in Chile. This work is part of a series of papers studying calibration, sensitivity, and systematic errors for SO. In this paper, we discuss current efforts to model optical systematic effects, how these have been used to guide the design of the SO instrument, and how these studies can be used to inform instrument design of future experiments like CMB-S4. While optical systematics studies are underway for both the small aperture and large aperture telescopes, we limit the focus of this paper to the more mature large aperture telescope design for which our studies include: pointing errors, optical distortions, beam ellipticity, cross-polar response, instrumental polarization rotation and various forms of sidelobe pickup., Comment: Poster presented at SPIE Astronomical Telescopes and Instrumentation 2018
Published: 2018
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136. Designs for next generation CMB survey strategies from Chile

Author: Stevens, Jason R., Goeckner-Wald, Neil, Keskitalo, Reijo, McCallum, Nialh, Ali, Aamir, Borrill, Julian, Brown, Michael L., Chinone, Yuji, Gallardo, Patricio A., Kusaka, Akito, Lee, Adrian T., McMahon, Jeff, Niemack, Michael D., Page, Lyman, Puglisi, Giuseppe, Salatino, Maria, Mak, Suet Ying D., Teply, Grant, Thomas, Daniel B., Vavagiakis, Eve M., Wollack, Edward J., Xu, Zhilei, and Zhu, Ningfeng
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: New telescopes are being built to measure the Cosmic Microwave Background (CMB) with unprecedented sensitivity, including Simons Observatory (SO), CCAT-prime, the BICEP Array, SPT-3G, and CMB Stage-4. We present observing strategies for telescopes located in Chile that are informed by the tools used to develop recent Atacama Cosmology Telescope (ACT) and Polarbear surveys. As with ACT and Polarbear, these strategies are composed of scans that sweep in azimuth at constant elevation. We explore observing strategies for both small (0.42 m) aperture telescopes (SAT) and a large (6 m) aperture telescope (LAT). We study strategies focused on small sky areas to search for inflationary gravitational waves as well as strategies spanning roughly half the low-foreground sky to constrain the effective number of relativistic species and measure the sum of neutrino masses via the gravitational lensing signal due to large scale structure. We present these strategies specifically considering the telescope hardware and science goals of the SO, located at 23 degrees South latitude, 67.8 degrees West longitude. Observations close to the Sun and the Moon can introduce additional systematics by applying additional power to the instrument through telescope sidelobes. Significant side lobe contamination in the data can occur even at tens of degrees or more from bright sources. Therefore, we present several strategies that implement Sun and Moon avoidance constraints into the telescope scheduling. Strategies for resolving conflicts between simultaneously visible fields are discussed. We focus on maximizing telescope time spent on science observations. It will also be necessary to schedule calibration measurements, however that is beyond the scope of this work. The outputs of this study are algorithms that can generate specific schedule commands for the Simons Observatory instruments., Comment: 15 pages, 9 figures, 3 tables, SPIE Astronomical Telescopes + Instrumentation 2018
Published: 2018
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137. Cold optical design for the Large Aperture Simons Observatory telescope

Author: Dicker, S. R., Gallardo, P. A., Gudmundsson, J. E, Mauskopf, P. D., Ali, A., Ashton, P. C., Coppi, G., Devlin, M. J., Galitzki, N., Ho, S. P., Hill, C. A., Hubmayr, J., Keating, B., Lee, A. T., Limon, M., Matsuda, F., McMahon, J., Niemack, M. D., Orlowski-Scherer, J. L., Piccirillo, L., Salatino, M., Simon, S. M., Staggs, S. T., Thornton, R., Ullom, J. N., Vavagiakis, E. M., Wollack, E. J., Xu, Z., and Zhu, N.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Simons Observatory will consist of a single large (6 m diameter) telescope and a number of smaller (0.5 m diameter) refracting telescopes designed to measure the polarization of the Cosmic Microwave Background to unprecedented accuracy. The large aperture telescope is the same design as the CCAT-prime telescope, a modified Crossed Dragone design with a field-of-view of over 7.8 degrees diameter at 90 GHz. This paper presents an overview of the cold reimaging optics for this telescope and what drove our choice of 350-400 mm diameter silicon lenses in a 2.4 m cryostat over other possibilities. We will also consider the future expandability of this design to CMB Stage-4 and beyond.
Published: 2018

138. The Simons Observatory: Instrument Overview

Author: Galitzki, Nicholas, Ali, Aamir, Arnold, Kam S., Ashton, Peter C., Austermann, Jason E., Baccigalupi, Carlo, Baildon, Taylor, Barron, Darcy, Beall, James A., Beckman, Shawn, Bruno, Sarah Marie M., Bryan, Sean, Calisse, Paolo G., Chesmore, Grace E., Chinone, Yuji, Choi, Steve K., Coppi, Gabriele, Crowley, Kevin D., Crowley, Kevin T., Cukierman, Ari, Devlin, Mark J., Dicker, Simon, Dober, Bradley, Duff, Shannon M., Dunkley, Jo, Fabbian, Giulio, Gallardo, Patricio A., Gerbino, Martina, Goeckner-Wald, Neil, Golec, Joseph E., Gudmundsson, Jon E., Healy, Erin E., Henderson, Shawn, Hill, Charles A., Hilton, Gene C., Ho, Shuay-Pwu Patty, Howe, Logan A., Hubmayr, Johannes, Jeong, Oliver, Keating, Brian, Koopman, Brian J., Kuichi, Kenji, Kusaka, Akito, Lashner, Jacob, Lee, Adrian T., Li, Yaqiong, Limon, Michele, Lungu, Marius, Matsuda, Frederick, Mauskopf, Philip D., May, Andrew J., McCallum, Nialh, McMahon, Jeff, Nati, Federico, Niemack, Michael D., Orlowski-Scherer, John L., Parshley, Stephen C., Piccirillo, Lucio, Rao, Mayuri Sathyanarayana, Raum, Christopher, Salatino, Maria, Seibert, Joseph S., Sierra, Carlos, Silva-Feaver, Max, Simon, Sara M., Staggs, Suzanne T., Stevens, Jason R., Suzuki, Aritoki, Teply, Grant, Thornton, Robert, Tsai, Calvin, Ullom, Joel N., Vavagiakis, Eve M., Vissers, Michael R., Westbrook, Benjamin, Wollack, Edward J., Xu, Zhilei, and Zhu, Ningfeng
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Simons Observatory (SO) will make precise temperature and polarization measurements of the cosmic microwave background (CMB) using a set of telescopes which will cover angular scales between 1 arcminute and tens of degrees, contain over 60,000 detectors, and observe at frequencies between 27 and 270 GHz. SO will consist of a 6 m aperture telescope coupled to over 30,000 transition-edge sensor bolometers along with three 42 cm aperture refractive telescopes, coupled to an additional 30,000+ detectors, all of which will be located in the Atacama Desert at an altitude of 5190 m. The powerful combination of large and small apertures in a CMB observatory will allow us to sample a wide range of angular scales over a common survey area. SO will measure fundamental cosmological parameters of our universe, constrain primordial fluctuations, find high redshift clusters via the Sunyaev-Zel`dovich effect, constrain properties of neutrinos, and trace the density and velocity of the matter in the universe over cosmic time. The complex set of technical and science requirements for this experiment has led to innovative instrumentation solutions which we will discuss. The large aperture telescope will couple to a cryogenic receiver that is 2.4 m in diameter and nearly 3 m long, creating a number of technical challenges. Concurrently, we are designing the array of cryogenic receivers housing the 42 cm aperture telescopes. We will discuss the sensor technology SO will use and we will give an overview of the drivers for and designs of the SO telescopes and receivers, with their cold optical components and detector arrays.
Published: 2018
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139. Advanced ACTPol TES Device Parameters and Noise Performance in Fielded Arrays

Author: Crowley, Kevin T., Austermann, Jason E., Choi, Steve K., Duff, Shannon M., Gallardo, Patricio A., Ho, Shuay-Pwu Patty, Hubmayr, Johannes, Koopman, Brian J., Nati, Federico, Niemack, Michael D., Salatino, Maria, Simon, Sara M., Staggs, Suzanne T., Stevens, Jason R., Ullom, Joel N., Vavagiakis, Eve M., and Wollack, Edward J.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The Advanced ACTPol (AdvACT) upgrade to the Atacama Cosmology Telescope (ACT) features arrays of aluminum manganese transition-edge sensors (TESes) optimized for ground-based observations of the Cosmic Microwave Background (CMB). Array testing shows highly responsive detectors with anticipated in-band noise performance under optical loading. We report on TES parameters measured with impedance data taken on a subset of TESes. We then compare modeled noise spectral densities to measurements. We find excess noise at frequencies around 100 Hz, nearly outside of the signal band of CMB measurements. In addition, we describe full-array noise measurements in the laboratory and in the field for two new AdvACT mid-frequency arrays, sensitive at bands centered on 90 and 150 GHz, and data for the high-frequency array (150/230 GHz) as deployed., Comment: Accepted for publication in Journal of Low Temperature Physics for LTD-17 special issue
Published: 2018
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140. BoloCalc: a sensitivity calculator for the design of Simons Observatory

Author: Hill, Charles A., Bruno, Sarah Marie M., Simon, Sara M., Ali, Aamir, Arnold, Kam S., Ashton, Peter C., Barron, Darcy, Bryan, Sean, Chinone, Yuji, Coppi, Gabriele, Crowley, Kevin T., Cukierman, Ari, Dicker, Simon, Dunkley, Jo, Fabbian, Giulio, Galitzki, Nicholas, Gallardo, Patricio A., Gudmundsson, Jon E., Hubmayr, Johannes, Keating, Brian, Kusaka, Akito, Lee, Adrian T., Matsuda, Frederick, Mauskopf, Philip D., McMahon, Jeffrey, Niemack, Michael D., Puglisi, Giuseppe, Rao, Mayuri Sathyanarayana, Salatino, Maria, Sierra, Carlos, Staggs, Suzanne, Suzuki, Aritoki, Teply, Grant, Ullom, Joel N., Westbrook, Benjamin, Xu, Zhilei, and Zhu, Ningfeng
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Simons Observatory (SO) is an upcoming experiment that will study temperature and polarization fluctuations in the cosmic microwave background (CMB) from the Atacama Desert in Chile. SO will field both a large aperture telescope (LAT) and an array of small aperture telescopes (SATs) that will observe in six bands with center frequencies spanning from 27 to 270~GHz. Key considerations during the SO design phase are vast, including the number of cameras per telescope, focal plane magnification and pixel density, in-band optical power and camera throughput, detector parameter tolerances, and scan strategy optimization. To inform the SO design in a rapid, organized, and traceable manner, we have created a Python-based sensitivity calculator with several state-of-the-art features, including detector-to-detector optical white-noise correlations, a handling of simulated and measured bandpasses, and propagation of low-level parameter uncertainties to uncertainty in on-sky noise performance. We discuss the mathematics of the sensitivity calculation, the calculator's object-oriented structure and key features, how it has informed the design of SO, and how it can enhance instrument design in the broader CMB community, particularly for CMB-S4., Comment: Submitted to the Proceedings of SPIE: Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy IX
Published: 2018
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141. PILOT balloon-borne experiment in-flight performance

Author: Mangilli, A., Foënard, G., Aumont, J., Hughes, A., Mot, B., Bernard, J-Ph., Lacourt, A., Ristorcelli, I., Longval, Y., Ade, P., André, Y., Bautista, L., deBernardis, P., Boulade, O., Bousqet, F., Bouzit, M., Buttice, V., Charra, M., Crane, B., Doumayrou, E., Dubois, J. P., Engel, C., Griffin, M., Grabarnik, S., Hargrave, P., Laureijs, R., Leriche, B., Maestre, S., Maffei, B., Marty, C., Marty, W., Masi, S., Misawa, R., Montel, J., Montier, L., Narbonne, J., Pajot, F., Pérot, E., Pimentao, J., Pisano, G., Ponthieu, N., Rodriguez, L., Roudil, G., Salatino, M., Savini, G., Simonella, O., Saccoccio, M., Stever, S., Tauber, J., Tibbs, C., and Tucker, C.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Polarized Instrument for Long-wavelength Observation of the Tenuous interstellar medium (PILOT) is a balloon-borne experiment aiming at measuring the polarized emission of thermal dust at a wavelength of 240 mm (1.2 THz). A first PILOT flight (flight#1) of the experiment took place from Timmins, Ontario, Canada, in September 2015 and a second flight (flight#2) took place from Alice Springs, Australia in april 2017. In this paper, we present the inflight performance of the instrument during these two flights. We concentrate on performances during flight#2, but allude to flight#1 performances if significantly different. We first present a short description of the instrument and the flights. We determine the time constants of our detectors combining inflight information from the signal decay following high energy particle impacts (glitches) and of our internal calibration source. We use these time constants to deconvolve the data timelines and analyse the optical quality of the instrument as measured on planets. We then analyse the structure and polarization of the instrumental background. We measure the detector response flat field and its time variations using the signal from the residual atmosphere and of our internal calibration source. Finally, we analyze the detector noise spectral and temporal properties. The in-flight performances are found to be satisfactory and globally in line with expectations from ground calibrations. We conclude by assessing the expected in-flight sensitivity of the instrument in light of the above in-flight performances.
Published: 2018

142. QUBIC - The Q&U Bolometric Interferometer for Cosmology - A novel way to look at the polarized Cosmic Microwave Background

Author: Mennella, A., Ade, P. A. R., Aumont, J., Banfi, S., Battaglia, P., Battistelli, E. S., Baù, A., Bélier, B., Bennett, D., Bergé, L., Bernard, J. Ph., Bersanelli, M., Bigot-Sazy, M. A., Bleurvacq, N., Bordier, G., Brossard, J., Bunn, E. F., Burke, D. P., Buzi, D., Buzzelli, A., Cammilleri, D., Cavaliere, F., Chanial, P., Chapron, C., Columbro, F., Coppi, G., Coppolecchia, A., Couchot, F., D'Agostino, R., D'Alessandro, G., de Bernardis, P., De Gasperis, G., De Leo, M., De Petris, M., Decourcelle, T., Del Torto, F., Dumoulin, L., Etchegoyen, A., Franceschet, C., Garcia, B., Gault, A., Gayer, D., Gervasi, M., Ghribi, A., Giard, M., Giraud-Héraud, Y., Gradziel, M., Grandsire, L., Hamilton, J. Ch., Harari, D., Haynes, V., Henrot-Versillé, S., Holtzer, N., Incardona, F., Kaplan, J., Korotkov, A., Krachmalnicoff, N., Lamagna, L., Lande, J., Loucatos, S., Lowitz, A., Lukovic, V., Maffei, B., Marnieros, S., Martino, J., Masi, S., May, A., McCulloch, M., Medina, M. C., Mele, L., Melhuish, S., Montier, L., Murphy, A., Néel, D., Ng, M. W., O'Sullivan, C., Paiella, A., Pajot, F., Passerini, A., Pelosi, A., Perbost, C., Perdereau, O., Piacentini, F., Piat, M., Piccirillo, L., Pisano, G., Préle, D., Puddu, R., Rambaud, D., Rigaut, O., Romero, G. E., Salatino, M., Schillaci, A., Scully, S., Stolpovskiy, M., Suarez, F., Tartari, A., Timbie, P., Torchinsky, S., Tristram, M., Tucker, C., Tucker, G., Viganò, D., Vittorio, N., Voisin, F., Watson, B., Zannoni, M., and Zullo, A.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: In this paper we describe QUBIC, an experiment that takes up the challenge posed by the detection of primordial gravitational waves with a novel approach, that combines the sensitivity of state-of-the art bolometric detectors with the systematic effects control typical of interferometers. The so-called "self-calibration" is a technique deeply rooted in the interferometric nature of the instrument and allows us to clean the measured data from instrumental effects. The first module of QUBIC is a dual band instrument (150 GHz and 220 GHz) that will be deployed in Argentina during the Fall 2018., Comment: Presented at the EPS Conference on High Energy Physics, Venice (Italy), 5-12 July 2017 Accepted for publication in conference proceedings
Published: 2018

143. The Initial ATA Risk Classification, but Not the AJCC/TNM Stage, Predicts the Persistence or Relapse of Differentiated Thyroid Cancer in Long-Term Surveillance

Author: Stefania Giuliano, Maria Mirabelli, Eusebio Chiefari, Vera Tocci, Alessandra Donnici, Stefano Iuliano, Alessandro Salatino, Daniela Patrizia Foti, Antonio Aversa, and Antonio Brunetti
Subjects: differentiated thyroid cancer, prognostic factors, AJCC/TNM stage, ATA classification, radioiodine, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Background: The American Joint Commission on Cancer on Tumor Node Metastasis (AJCC/TNM) staging system provides adequate information on the risk of differentiated thyroid cancer (DTC)-specific mortality in totally thyroidectomized patients, but its role in predicting persistence and relapse of disease is uncertain. The relatively new 2015 American Thyroid Association (ATA) guidelines recommend stratifying patients at the time of DTC diagnosis with its own risk classification system, in order to identify those at high risk of residual or recurrent morbidity who may benefit from post-operative radioiodine (RAI) administration and/or need additional work-up. Methods: To verify the prevalence proportion of persistence or relapse of disease, a consecutive cohort of 152 patients with a diagnosis of DTC, subjected to total thyroidectomy (+/− post-operative RAI administration as per guidelines indication) and to neck ultrasonography (US), as well as biochemical surveillance for a minimum of 2 years at the Endocrinology Unit of Mater-Domini Hospital (Catanzaro, Italy), was enrolled. The prognostic role of the AJCC/TNM stage and ATA risk classification system was analyzed by logistic regression. Results: At a mean of 9 years after surgical treatment, DTC was found to persist or relapse in 19 (12.5%) participants. The initial risk for these outcomes, based on the ATA classification, was mostly low (53.9%) or intermediate (39.5%). AJCC/TNM stages were predominantly stage I or stage II. Despite a small representation in this cohort, high-risk patients according to the ATA classification had 8-fold higher odds of persistence or relapse of disease than those of low-risk participants, while controlling for potential risk modifiers, including age at DTC diagnosis, male gender, and post-operative RAI administration (p = 0.008). In contrast, the AJCC/TNM stage was not associated with the disease status at the last follow-up visit (p = 0.068 for the 7th Edition; p = 0.165 for the 8th Edition). Furthermore, low-risk participants subjected to post-operative RAI administration had the same probability of persistence or relapse of DTC when compared to those who had undergone total thyroidectomy only. Conclusions: There is a need for the endocrine community to revise the current work-up of DTC. The initial ATA risk classification is a reliable tool for predicting the persistence or relapse of disease in long-term surveillance.
Published: 2022
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144. Biases of Temporal Duration Judgements in Visual and Auditory System

Author: Gaetana Chillemi, Francesco Corallo, Alessandro Calamuneri, Adriana Salatino, Alberto Cacciola, Raffaella Ricci, and Angelo Quartarone
Subjects: auditory system, visual system, attention bias, exposure time, target, reference, Psychology, BF1-990
Abstract: Background: There is evidence that temporal duration is spatially represented on a horizontal mental timeline (MTL) with relatively short durations represented on the left and long duration on the right side. Most of this evidence comes from the visual domain. Objective: With the present study, we investigated whether temporal duration judgements of visual and auditory stimuli might be affected by spatial biases in time representation. Methods: Participants were asked to estimate the temporal duration of a target with respect to a reference stimulus. Two different exposure times were used for the reference (fast and slow), and three exposure times for the target with respect to the reference (shorter, equal, longer). Two versions of the task were implemented to probe visual and auditory temporal processing. Results: Participants showed enhanced performance when the target had longer duration than the reference independently of the type of task, but they were affected in opposite ways by the reference exposure time, in the two tasks. Best performance was observed for the fast reference in the visual domain and for the slow reference in the auditory one. Discussion: We argue that these findings provide evidence that temporal judgments of visual and auditory stimuli are affected by the duration of the reference stimulus, besides the duration of the target stimulus. Interestingly, they suggest putative leftward and rightward spatial biases in time representation for the visual and auditory domains, respectively, although future studies are necessary to further investigate these initial findings.
Published: 2022
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145. Presentación del dosier: Debates contemporáneos en torno a las revistas científicas: miradas latinoamericanas a problemáticas globales

Author: Maximiliano Salatino
Subjects: Bibliography. Library science. Information resources
Abstract: Presentación del dosier: Debates contemporáneos en torno a las revistas científicas: miradas latinoamericanas a problemáticas globales
Published: 2023
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146. Genomic regulation of Krüppel-like-factor family members by corticosteroid receptors in the rat brain

Author: Clare L.M. Kennedy, Emily M. Price, Karen R. Mifsud, Silvia Salatino, Eshita Sharma, Simon Engledow, John Broxholme, Hannah M. Goss, and Johannes M.H.M. Reul
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429, Neurophysiology and neuropsychology, QP351-495
Abstract: Hippocampal mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) mediate glucocorticoid hormone (GC) action in the hippocampus. These receptors bind to glucocorticoid responsive elements (GREs) within target genes, eliciting transcriptional effects in response to stress and circadian variation. Until recently, little was known about the genome-wide targets of hippocampal MRs and GRs under physiological conditions. Following on from our genome-wide MR and GR ChIP-seq and Ribo-Zero RNA-seq studies on rat hippocampus, we investigated the Krüppel-like factors (KLFs) as targets of MRs and GRs throughout the brain under circadian variation and after acute stress. In particular, Klf2, Klf9 and Klf15 are known to be stress and/or GC responsive and play a role in neurobiological processes including synaptic plasticity and neuronal differentiation. We found increased binding of MR and GR to GREs within Klf2, Klf9 and Klf15 in the hippocampus, amygdala, prefrontal cortex, and neocortex after acute stress and resulting from circadian variation, which was accompanied by upregulation of corresponding hnRNA and mRNA levels. Adrenalectomy abolished transcriptional upregulation of specific Klf genes. These results show that MRs and GRs regulate Klf gene expression throughout the brain following exposure to acute stress or in response to circadian variation, likely alongside other transcription factors.
Published: 2023
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147. Single-cell heterogeneity of EGFR and CDK4 co-amplification is linked to immune infiltration in glioblastoma

Author: Kacper A. Walentynowicz, Dalit Engelhardt, Simona Cristea, Shreya Yadav, Ugoma Onubogu, Roberto Salatino, Melanie Maerken, Cristina Vincentelli, Aashna Jhaveri, Jacob Geisberg, Thomas O. McDonald, Franziska Michor, and Michalina Janiszewska
Subjects: CP: Cancer, Biology (General), QH301-705.5
Abstract: Summary: Glioblastoma (GBM) is the most aggressive brain tumor, with a median survival of ∼15 months. Targeted approaches have not been successful in this tumor type due to the large extent of intratumor heterogeneity. Mosaic amplification of oncogenes suggests that multiple genetically distinct clones are present in each tumor. To uncover the relationships between genetically diverse subpopulations of GBM cells and their native tumor microenvironment, we employ highly multiplexed spatial protein profiling coupled with single-cell spatial mapping of fluorescence in situ hybridization (FISH) for EGFR, CDK4, and PDGFRA. Single-cell FISH analysis of a total of 35,843 single nuclei reveals that tumors in which amplifications of EGFR and CDK4 more frequently co-occur in the same cell exhibit higher infiltration of CD163+ immunosuppressive macrophages. Our results suggest that high-throughput assessment of genomic alterations at the single-cell level could provide a measure for predicting the immune state of GBM.
Published: 2023
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148. OLIVA: La Producción Científica Indexada en América Latina. Diversidad Disciplinar, Colaboración Institucional y Multilingüismo en SciELO y Redalyc (1995-2018)

Author: Fernanda Beigel, Abel L. Packer, Osvaldo Gallardo, and Maximiliano Salatino
Subjects: revistas indexadas, SciELO, Redalyc, colaboración nacional, colaboración internacional, Social sciences (General), H1-99
Abstract: Resumen Este artículo presenta los resultados del Observatorio Latinoamericano de Indicadores de eVAluación (OLIVA), que buscar visibilizar y promover la valoración de la producción científica indexada en América Latina y el Caribe. Se aborda la producción publicada en acceso abierto e indexada en SciELO y Redalyc, a partir de la construcción de una base de datos consolidada y que incluye información de 1.720 revistas (de 15 países), 908.982 documentos y 2.591.704 autores/as. Se analiza la diversidad disciplinar de esta producción, así como las tendencias de la colaboración nacional, regional e internacional. También, sólo para el caso de Brasil y de SciELO, se analiza la colaboración intra-nacional. Los resultados arrojan un predominio de revistas diamante, de instituciones editoras universitarias y de formas de circulación multiescalar. Estos rasgos, así como la diversidad lingüística y disciplinar, pueden contribuir de modo eficaz a las necesidades de la comunicación científica en tiempos de ciencia abierta.
Published: 2023
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149. Novel canonical and non-canonical viral antigens extend current targets for immunotherapy of HPV-driven cervical cancer

Author: Xu Peng, Isaac Woodhouse, Gemma Hancock, Robert Parker, Kristina Marx, Julius Müller, Silvia Salatino, Thomas Partridge, Annalisa Nicastri, Hanqing Liao, Gary Kruppa, Karin Hellner, Lucy Dorrell, and Nicola Ternette
Subjects: Immunology, Cell biology, Cancer, Science
Abstract: Summary: Current immunotherapeutic approaches for human papillomavirus (HPV)-driven cervical cancer target the viral oncogenes E6 and E7. We report viral canonical and alternative reading frame (ARF)-derived sequences presented on cervical tumor cells, including antigens encoded by the conserved viral gene E1. We confirm immunogenicity of the identified viral peptides in HPV-positive women, and women with cervical intraepithelial neoplasia. We observe consistent transcription of the E1, E6, and E7 genes in 10 primary cervical tumor resections from the four most common high-risk HPV subtypes (HPV16, 18, 31, and 45), suggesting the suitability of E1 as therapeutic target. We finally confirm HLA presentation of canonical peptides derived from E6 and E7, and ARF-derived viral peptides from a reverse-strand transcript spanning the HPV E1 and E2 genes in primary human cervical tumor tissue. Our results extend currently known viral immunotherapeutic targets in cervical cancer and highlight E1 as an important cervical cancer antigen.
Published: 2023
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150. Bioreactor modelling for syngas fermentation: Kinetic characterization

Author: Ruggiero, G., Lanzillo, F., Raganati, F., Russo, M.E., Salatino, P., and Marzocchella, A.
Published: 2022
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