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101. Relationship between anti-erythropoietin receptor autoantibodies and responsiveness to erythropoiesis-stimulating agents in patients on hemodialysis: a multi-center cross-sectional study

Author

Hara, Akinori, primary, Koshino, Yoshitaka, additional, Kurokawa, Yukie, additional, Shinozaki, Yasuyuki, additional, Miyake, Taito, additional, Kitajima, Shinji, additional, Toyama, Tadashi, additional, Iwata, Yasunori, additional, Sakai, Norihiko, additional, Shimizu, Miho, additional, Furuichi, Kengo, additional, Nakamura, Hiroyuki, additional, and Wada, Takashi, additional

Published
2019
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102. Erythropoietin signal protected human umbilical vein endothelial cells from high glucose‐induced injury

Author

Yasuda, Haruka, primary, Iwata, Yasunori, additional, Nakajima, Satoshi, additional, Furuichi, Kengo, additional, Miyake, Taito, additional, Sakai, Norihiko, additional, Kitajima, Shinji, additional, Toyama, Tadashi, additional, Shinozaki, Yasuyuki, additional, Sagara, Akihiro, additional, Miyagawa, Taro, additional, Hara, Akinori, additional, Shimizu, Miho, additional, Kamikawa, Yasutaka, additional, Sato, Kouichi, additional, Oshima, Megumi, additional, Yoneda‐Nakagawa, Shiori, additional, Kaneko, Shuichi, additional, and Wada, Takashi, additional

Published
2019
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103. Evaluation of renal oxygen saturation using photoacoustic imaging for the early prediction of chronic renal function in a model of ischemia-induced acute kidney injury

Author

Okumura, Kenichiro, primary, Matsumoto, Junichi, additional, Iwata, Yasunori, additional, Yoshida, Kotaro, additional, Yoneda, Norihide, additional, Ogi, Takahiro, additional, Kitao, Azusa, additional, Kozaka, Kazuto, additional, Koda, Wataru, additional, Kobayashi, Satoshi, additional, Inoue, Dai, additional, Sakai, Norihiko, additional, Furuichi, Kengo, additional, Wada, Takashi, additional, and Gabata, Toshifumi, additional

Published
2018
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104. Higher serum levels of autotaxin and phosphatidylserine‐specific phospholipase A1 in patients with lupus nephritis.

Author

Iwata, Yasunori, Kitajima, Shinji, Yamahana, Junya, Shimomura, Shuji, Yoneda‐Nakagawa, Shiori, Sakai, Norihiko, Furuichi, Kengo, Ogura, Hisayuki, Sato, Koichi, Toyama, Tadashi, Yamamura, Yuta, Miyagawa, Taro, Hara, Akinori, Shimizu, Miho, Ohkawa, Ryunosuke, Kurano, Makoto, Yatomi, Yutaka, and Wada, Takashi

Subjects
AUTOTAXIN, LUPUS nephritis, SERUM, DIABETIC nephropathies, CLINICAL pathology, BIOMARKERS, LYSOPHOSPHOLIPIDS
Abstract

Background: Recent studies revealed that lysophospholipids (LPLs) and related molecules, such as autotaxin (ATX) and phosphatidylserine‐specific phospholipase A1 (PS‐PLA1), are candidates for novel biomarkers in melanoma, glaucoma and diabetic nephropathy. However, it is not clear whether serum levels of ATX/ PS‐PLA1 would be associated with pathological and clinical findings of lupus nephritis (LN). Methods: In this retrospective cohort study, serum samples were collected from 39 patients with LN and 37 patients with other glomerular diseases. The serum levels of ATX and PS‐PLA1 were evaluated for an association with renal pathology and clinical phenotypes of LN. Results: The serum levels of ATX and PS‐PLA1 were higher in the patients with LN as compared to those with other glomerular diseases. Among the classes of LN, the patients with class IV showed the trend of lower serum levels of ATX. Moreover, the patients with lower levels of ATX exhibited higher scores of activity index (AI) and chronicity index (CI). The level of ATX tended to be negatively correlated with AI and CI. These results might be explained by the effect of treatment, because the serum levels of ATX and PS‐PLA1 were inversely correlated with the daily amount of oral prednisolone. Moreover, they did not reflect the level of proteinuria or kidney survival in LN patients. Conclusion: Although the serum levels of ATX and PS‐PLA1 were affected by the treatment, these levels were higher in the patients with LN. The potential clinical benefits of these markers need to be clarified in further studies. [ABSTRACT FROM AUTHOR]

Published
2021
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105. Effects of LDL apheresis on proteinuria in patients with diabetes mellitus, severe proteinuria, and dyslipidemia.

Author

Wada, Takashi, Hara, Akinori, Muso, Eri, Maruyama, Shoichi, Kato, Sawako, Furuichi, Kengo, Yoshimura, Kenichi, Toyama, Tadashi, Sakai, Norihiko, Suzuki, Hiroyuki, Tsukamoto, Tatsuo, Miyazaki, Mariko, Sato, Eiichi, Abe, Masanori, Shibagaki, Yugo, Narita, Ichiei, Goto, Shin, Sakamaki, Yuichi, Yokoyama, Hitoshi, and Mori, Noriko

Subjects
PEOPLE with diabetes, LOW density lipoproteins, DIABETES, PROTEINURIA, DIABETIC nephropathies, DYSLIPIDEMIA, FOCAL segmental glomerulosclerosis
Abstract

Background: Patients with diabetes mellitus and severe proteinuria present with poor renal prognoses, despite improvements in diabetes and kidney disease therapies. In this study, we designed a low-density lipoprotein (LDL)-cholesterol apheresis treatment for patients with diabetic nephropathy (DN)/diabetic kidney disease and severe proteinuria. This was a multicenter prospective LICENSE study to confirm the impact of LDL apheresis on proteinuria that exhibited hyporesponsiveness to treatment. In addition, we sought to determine the efficacy and safety of LDL apheresis by comparing the outcomes to those of historical controls in patients with diabetes, refractory hypercholesterolemia, and severe proteinuria. Methods: This was a prospective, multicenter study, including 40 patients with diabetes, severe proteinuria, and dyslipidemia. LDL apheresis was performed 6–12 times over a 12-week period. The primary endpoint was the proportion of patients with a decrease in proteinuria excretion of at least 30% in the 6 months after starting therapy. The secondary endpoints included serum creatinine levels and laboratory variables, which were evaluated 4, 6, 12, 18, and 24 months after therapy initiation. Results: LDL apheresis was performed on 40 registered patients with diabetes. The proportion of cases in which proteinuria decreased by 30% or more after 6 months of LDL apheresis was 25%, which was similar to that of historical controls. The overall survival and end-stage kidney disease-free survival rates were significantly higher in the LICENSE group compared to those in historical controls. Conclusion: Our results suggest that LDL apheresis may be effective and safe for patients with diabetes, proteinuria, and dyslipidemia. Trial registration: Trial registration number: jRCTs042180076. [ABSTRACT FROM AUTHOR]

Published
2021
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106. Gut microbiota–derived D-serine protects against acute kidney injury

Author

Nakade, Yusuke, primary, Iwata, Yasunori, additional, Furuichi, Kengo, additional, Mita, Masashi, additional, Hamase, Kenji, additional, Konno, Ryuichi, additional, Miyake, Taito, additional, Sakai, Norihiko, additional, Kitajima, Shinji, additional, Toyama, Tadashi, additional, Shinozaki, Yasuyuki, additional, Sagara, Akihiro, additional, Miyagawa, Taro, additional, Hara, Akinori, additional, Shimizu, Miho, additional, Kamikawa, Yasutaka, additional, Sato, Kouichi, additional, Oshima, Megumi, additional, Yoneda-Nakagawa, Shiori, additional, Yamamura, Yuta, additional, Kaneko, Shuichi, additional, Miyamoto, Tetsuya, additional, Katane, Masumi, additional, Homma, Hiroshi, additional, Morita, Hidetoshi, additional, Suda, Wataru, additional, Hattori, Masahira, additional, and Wada, Takashi, additional

Published
2018
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107. The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis

Author

Knipe, Rachel S., primary, Probst, Clemens K., additional, Lagares, David, additional, Franklin, Alicia, additional, Spinney, Jillian J., additional, Brazee, Patricia L., additional, Grasberger, Paula, additional, Zhang, Linlin, additional, Black, Katharine E., additional, Sakai, Norihiko, additional, Shea, Barry S., additional, Liao, James K., additional, Medoff, Benjamin D., additional, and Tager, Andrew M., additional

Published
2018
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108. Involvement of p38MAPK in Impaired Neutrophil Bactericidal Activity of Hemodialysis Patients

Author

Kamikawa, Yasutaka, primary, Sakai, Norihiko, additional, Miyake, Taito, additional, Sagara, Akihiro, additional, Shinozaki, Yasuyuki, additional, Kitajima, Shinji, additional, Toyama, Tadashi, additional, Hara, Akinori, additional, Iwata, Yasunori, additional, Shimizu, Miho, additional, Furuichi, Kengo, additional, Imamura, Ryu, additional, Suda, Takashi, additional, Kaneko, Shuichi, additional, and Wada, Takashi, additional

Published
2018
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110. Impairment of the carnitine/organic cation transporter 1–ergothioneine axis is mediated by intestinal transporter dysfunction in chronic kidney disease

Author

Shinozaki, Yasuyuki, primary, Furuichi, Kengo, additional, Toyama, Tadashi, additional, Kitajima, Shinji, additional, Hara, Akinori, additional, Iwata, Yasunori, additional, Sakai, Norihiko, additional, Shimizu, Miho, additional, Kaneko, Shuichi, additional, Isozumi, Noriyoshi, additional, Nagamori, Shushi, additional, Kanai, Yoshikatsu, additional, Sugiura, Tomoko, additional, Kato, Yukio, additional, and Wada, Takashi, additional

Published
2017
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111. Relationship between serum uric acid levels and chronic kidney disease in a Japanese cohort with normal or mildly reduced kidney function

Author

Toyama, Tadashi, Furuichi, Kengo, Shimizu, Miho, Hara, Akinori, Iwata, Yasunori, Sakai, Norihiko, Perkovic, Vlado, Kobayashi, Makoto, Mano, Toshiki, Kaneko, Shuichi, Wada, Takashi, Toyama, Tadashi, Furuichi, Kengo, Shimizu, Miho, Hara, Akinori, Iwata, Yasunori, Sakai, Norihiko, Perkovic, Vlado, Kobayashi, Makoto, Mano, Toshiki, Kaneko, Shuichi, and Wada, Takashi

Abstract

Background: Some observational studies have shown the relationships between hyperuricemia and chronic kidney disease (CKD); however, the threshold of serum uric acid (SUA) for deterioration of kidney function and the association between SUA and kidney injury by baseline kidney function remains unclear. This study aimed to clarify the relationships between SUA and reduced kidney function. Methods: We analyzed a historical cohort of male Japanese individuals who underwent medical checkup between 1998 and 2007. Participants with baseline data and who were followed up for at least one year were included and stratified according to baseline kidney function. Kidney function was classified as normal [estimated glomerular filtration rate (eGFR) ≥ 90 ml/min/1.73 m2] or mildly reduced (eGFR 60-89 ml/min/1.73 m2). The outcome measured was kidney impairment defined as a decrease in eGFR to < 60 ml/min/1.73 m2. Associations between SUA and risk for outcome and eGFR slopes were assessed. Results: A total of 41632 subjects with mean age 45.4 years were included. During a mean follow-up of four years, 3186 (7.6%) subjects developed kidney dysfunction. Subjects with SUA ≥ 6.0 mg/dL had a significantly increased risk for kidney impairment compared with subjects with SUA of 4-4.9 mg/dL. SUA threshold levels were different according to baseline kidney function; SUA ≤ 7.0 and ≤ 6.0 mg/dL for normal and mildly reduced kidney function, respectively. Approximately the same trends were observed for eGFR slopes. Conclusion: In the general population, hyperuricemia appears to be a risk factor for kidney impairment in males. For participants with mild kidney dysfunction, even a slight elevation of SUA can be a risk factor. Copyright: © 2015 Toyama et al., This article has a supplementary figure. Please see the last page of the text.

Published
2017

112. Inhibition of NLRP3 inflammasome as a therapeutic intervention in crystal-induced nephropathy

Author

Sakai, Norihiko, Furuichi, Kengo, Wada, Takashi, Sakai, Norihiko, Furuichi, Kengo, and Wada, Takashi

Abstract

Inflammasomes are important components of innate immunity system. Dysregulation of inflammasomes activation is central to the pathogenesis of inflammatory diseases. The measurement of inflammasomes activity especially in in vivo settings should give us important information to regulate inflammatory events. Ludwig-Portugall et al. clearly visualized the intrarenal activation of inflammasome in a murine model of crystal nephropathy using a proteolytic luciferase-based reporter, and showed that the blockade of NLRP3 inflammasome may prevent renal injuries. © 2016 International Society of Nephrology, Embargo Period 12 months

Published
2017

113. Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis

Author

Sakai, Norihiko, primary, Nakamura, Miki, additional, Lipson, Kenneth E., additional, Miyake, Taito, additional, Kamikawa, Yasutaka, additional, Sagara, Akihiro, additional, Shinozaki, Yasuyuki, additional, Kitajima, Shinji, additional, Toyama, Tadashi, additional, Hara, Akinori, additional, Iwata, Yasunori, additional, Shimizu, Miho, additional, Furuichi, Kengo, additional, Kaneko, Shuichi, additional, Tager, Andrew M., additional, and Wada, Takashi, additional

Published
2017
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116. Association of renal arteriosclerosis and hypertension with renal and cardiovascular outcomes in Japanese type 2 diabetes patients with diabetic nephropathy.

Author

Shimizu, Miho, Furuichi, Kengo, Toyama, Tadashi, Funamoto, Tomoaki, Kitajima, Shinji, Hara, Akinori, Iwata, Yasunori, Sakai, Norihiko, Takamura, Toshinari, Kitagawa, Kiyoki, Yoshimura, Mitsuhiro, Kaneko, Shuichi, Yokoyama, Hitoshi, and Wada, Takashi

Subjects
DIABETIC nephropathies, TYPE 2 diabetes, PEOPLE with diabetes, ARTERIOSCLEROSIS, GLOMERULAR filtration rate, HYPERTENSION
Abstract

Aims/Introduction: The present retrospective study investigated the impact of renal arteriosclerosis (AS) and hypertension (HT) on long‐term renal and cardiovascular outcomes in Japanese type 2 diabetes patients with biopsy‐proven diabetic nephropathy. Materials and Methods: A total of 185 patients were enrolled. Patients were divided into four groups stratified by renal AS status and the presence of HT. The outcomes for this study were the first occurrence of renal events (a need for dialysis or a 30% decline in estimated glomerular filtration rate from baseline) and cardiovascular events (cardiovascular death, non‐fatal myocardial infarction, coronary intervention or non‐fatal stroke). Results: The proportion of renal AS scores ≥1 was 88.3% among patients with normal‐range blood pressure (BP) and 95.4% among patients with HT. During a mean follow‐up period of 7.6 years, 129 episodes of renal composite events and 55 episodes of cardiovascular events were observed. Compared with patients with no renal AS and normal‐range BP, a renal AS score ≥1 increased the risk of renal composite events with a multivariable‐adjusted hazard ratio of 3.21 (95% confidence interval [95% CI] 1.27–8.14) in patients with normal‐range BP and 4.99 (95% CI 1.98–12.54) in patients with HT, whereas renal AS score ≥1 increased the risk of cardiovascular events with a multivariable‐adjusted hazard ratio of 6.06 (95% CI 1.24–29.61) in patients with normal‐range BP and 10.02 (95% CI 1.92–52.39) in patients with HT. Conclusions: Renal AS was associated with increasing risks for renal composite events and cardiovascular events in both normal‐range BP and HT. The risks of renal composite events and cardiovascular events were the highest in both renal AS and HT. [ABSTRACT FROM AUTHOR]

Published
2019
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126. Association of apoptosis inhibitor of macrophage (AIM) expression with urinary protein and kidney dysfunction

Author

Oshima, Megumi, primary, Iwata, Yasunori, additional, Furuichi, Kengo, additional, Sakai, Norihiko, additional, Shimizu, Miho, additional, Hara, Akinori, additional, Kitajima, Shinji, additional, Toyama, Tadashi, additional, Shinozaki, Yasuyuki, additional, Sagara, Akihiro, additional, Umeda, Eri, additional, Kaneko, Shuichi, additional, Arai, Satoko, additional, Miyazaki, Toru, additional, and Wada, Takashi, additional

Published
2016
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127. GOUT AND NUCLEIC ACID METABOLISM

Author

Kitajima, Shinji, primary, Toyama, Tadashi, additional, Hara, Akinori, additional, Iwata, Yasunori, additional, Sakai, Norihiko, additional, Shimizu, Miho, additional, Furuichi, Kengo, additional, and Wada, Takashi, additional

Published
2016
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129. Association of PAX2 and Other Gene Mutations with the Clinical Manifestations of Renal Coloboma Syndrome

Author

Okumura, Toshiya, primary, Furuichi, Kengo, additional, Higashide, Tomomi, additional, Sakurai, Mayumi, additional, Hashimoto, Shin-ichi, additional, Shinozaki, Yasuyuki, additional, Hara, Akinori, additional, Iwata, Yasunori, additional, Sakai, Norihiko, additional, Sugiyama, Kazuhisa, additional, Kaneko, Shuichi, additional, and Wada, Takashi, additional

Published
2015
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131. Relationship between Serum Uric Acid Levels and Chronic Kidney Disease in a Japanese Cohort with Normal or Mildly Reduced Kidney Function

Author

Toyama, Tadashi, primary, Furuichi, Kengo, additional, Shimizu, Miho, additional, Hara, Akinori, additional, Iwata, Yasunori, additional, Sakai, Norihiko, additional, Perkovic, Vlado, additional, Kobayashi, Makoto, additional, Mano, Toshiki, additional, Kaneko, Shuichi, additional, and Wada, Takashi, additional

Published
2015
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132. An autopsy case of vertebrobasilar dolichoectasia under hemodialysis due to autosomal dominant polycystic kidney disease

Author

Nakagawa, Shiori, primary, Furuichi, Kengo, additional, Sagara, Akihiro, additional, Shinozaki, Yasuyuki, additional, Kitajima, Shinji, additional, Toyama, Tadashi, additional, Hara, Akinori, additional, Iwata, Yasunori, additional, Sakai, Norihiko, additional, Shimizu, Miho, additional, Matsui, Kazuhiro, additional, Kaneko, Shuichi, additional, Toyama, Tatsuhiko, additional, and Wada, Takashi, additional

Published
2015
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134. Calciphylaxis induced by warfarin therapy in a patient with anti-phospholipid antibody syndrome associated with systemic lupus erythematosus

Author

Shinozaki, Yasuyuki, primary, Furuichi, Kengo, additional, Sagara, Akihiro, additional, Kitajima, Shinji, additional, Toyama, Tadashi, additional, Hara, Akinori, additional, Iwata, Yasunori, additional, Sakai, Norihiko, additional, Shimizu, Miho, additional, Kaneko, Shuichi, additional, and Wada, Takashi, additional

Published
2014
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147. Dendritic Cells Contribute to Autoimmune Kidney Injury in MRL-Faslpr Mice

Author

IWATA, YASUNORI, primary, FURUICHI, KENGO, additional, SAKAI, NORIHIKO, additional, YAMAUCHI, HIROYUKI, additional, SHINOZAKI, YASUYUKI, additional, ZHOU, HAIYAN, additional, KUROKAWA, YUKIE, additional, TOYAMA, TADASHI, additional, KITAJIMA, SHINJI, additional, OKUMURA, TOSHIYA, additional, YAMADA, SHINGO, additional, MARUYAMA, IKURO, additional, MATSUSHIMA, KOUJI, additional, KANEKO, SHUICHI, additional, and WADA, TAKASHI, additional

Published
2009
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150. Blockade of IP-10/CXCR3 Promotes Progressive Renal Fibrosis

Author

Nakaya, Izaya, primary, Wada, Takashi, additional, Furuichi, Kengo, additional, Sakai, Norihiko, additional, Kitagawa, Kiyoki, additional, Yokoyama, Hitoshi, additional, Ishida, Yuko, additional, Kondo, Toshikazu, additional, Sugaya, Takeshi, additional, Kawachi, Hiroshi, additional, Shimizu, Fujio, additional, Narumi, Shosaku, additional, Haino, Makoto, additional, Gerard, Craig, additional, Matsushima, Kouji, additional, and Kaneko, Shuichi, additional

Published
2007
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