Search

Your search keyword '"Saeger, W."' showing total 842 results
Start Over Author "Saeger, W."
842 results on '"Saeger, W."'

106. B. Pituitary adenomas

Author

Scriba P. C., Engelhardt Fr., Fahlbusch R., Kracht J., Hachmeister U., Saeger W., Pickardt, C. R., Erhardt, F., Grüner, J., Kautzky R., Lüdecke, D., Piotrowski W., Penholz, H., Piscol, K., Riechert T., Lorenz R., Scharphuis T., Halves, E., Gramme, Th., Böck F., Koos, W., Gratzl O., Mundinger F., Krenkel W., Zimmermann H. H., Solbach, G., Wiegelmann, W., Frahm, H., Nowakowski H., Freisenhausen H. D., Altenburg H., Waldbaur, H., Wolf, F., Clar H. E., Römer, F., Hirschbiegel H., Ischebeck, W., Ruf H., v. Wild, K., Neubauer, M., Brenner H., Röttger, P., and Krücke, W.

Published
1973
Full Text
View/download PDF

108. Klinische Bedeutung von TP53-Alterationen beim Nebennierenrindenkarzinom (ACC)

Author

Waldmann, J, Patsalis, N, Fendrich, V, Langer, P, Saeger, W, Chalopuka, B, Bartsch, DK, and Slater, EP

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: TP53 Genmutationen induzieren eine nukleäre Akkumulation von TP53, die immunhistochemisch(IHC) nachgewiesen werden kann. Bei anderen soliden Tumoren sind TP53 Mutationen aber nur in 50-65% der IHC positiven Tumore nachweisbar, während dieser Zusammenhang beim ACC bisher nur[for full text, please go to the a.m. URL], 128. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2011
Full Text
View/download PDF

112. Pathologie

Author

Bässler, R., primary, Böcker, W., additional, Dallenbach-Hellweg, G., additional, Delling, G., additional, Harms, D., additional, Klöppel, G., additional, Mohr, W., additional, Müntefering, H., additional, Saeger, W., additional, Scherer, R., additional, Schubert, G. E., additional, Städtler, F., additional, Vogel, M., additional, and Wolff, H. H., additional

Published
1984
Full Text
View/download PDF

114. Pathologie der endokrinen Organe

Author

Altenähr, E., primary, Bröcker, W., additional, Dhom, G., additional, Gusek, W., additional, Heitz, Ph. U., additional, Klöppel, G., additional, Lietz, H., additional, Mitschke, H., additional, Saeger, W., additional, Schäfer, H. J., additional, Staub, J.-J., additional, and Steiner, H., additional

Published
1981
Full Text
View/download PDF

115. 'Occult' mastocytosis with activating c‐kit point mutation evolving into systemic mastocytosis associated with plasma cell myeloma and secondary amyloidosis

Author

H.-P. Horny, Saeger W, Florian Stellmacher, Stahmer J, Karl Sotlar, Jäckle S, and Peter Valent

Subjects
Male, Pathology, medicine.medical_specialty, Case Report, Biology, Pathology and Forensic Medicine, Mastocytosis, Systemic, Biopsy, Plasma Cell Myeloma, medicine, Humans, Point Mutation, Systemic mastocytosis, Lymph node, Multiple myeloma, B cell, Aged, medicine.diagnostic_test, Amyloidosis, General Medicine, medicine.disease, Intestinal Diseases, Proto-Oncogene Proteins c-kit, medicine.anatomical_structure, Disease Progression, Bone marrow, Multiple Myeloma, Mastocytosis
Abstract

A case of a 70-year-old man presenting with exsudative enteropathy due to light-chain-associated amyloidosis is reported. The diagnosis of systemic mastocytosis associated with IgG/lambda plasma cell myeloma and secondary generalised amyloidosis was carried out by morphological evaluation of bone marrow biopsy. The c-kit point mutation D816Y was detected by molecular analysis. Two years before, a cystadenolymphoma of the left parotid gland had been removed. A moderate increase of loosely scattered spindle-shaped mast cells, a subpopulation of them expressing CD25, an antigen that is not expressed by normal or reactive mast cells, was shown by retrospective analysis carried out on an intraparotideal lymph node. The c-kit mutation D816Y was shown by the molecular analysis of the lymph node. In summary, the notion that systemic mastocytosis may very rarely be associated with B cell neoplasms and that neoplastic mast cell infiltrates may be obscured because of only a minimal increase of atypical mast cells, which are outnumbered by other non-neoplastic cells in the same tissue, is supported by this case. This finding was preliminarily termed "occult" mastocytosis.

Published
2006

117. Transient pregnancy-induced Cushing's Syndrome with Aberrant Adrenal hCG receptor

Author

Plöckinger, U, primary, Tiling, N, additional, Blankenstein, O, additional, Weizsäcker, K von, additional, Allolio, B, additional, Kroiss, M, additional, Hauptmann, K, additional, Saeger, W, additional, Radke, C, additional, Steinmüller, T, additional, Rahman, N, additional, Chrusciel, M, additional, Doroszko, M, additional, Lacroix, A, additional, Huhtaniemi, I, additional, and Quinkler, M, additional

Published
2014
Full Text
View/download PDF

119. Ectopic ACTH-secreting pituitary adenomas

Author

Knappe, UJ, primary, Jaspers, C, additional, Buschsieweke, D, additional, Salbeck, R, additional, Saeger, W, additional, Ehlenz, K, additional, Feldkamp, J, additional, and Mann, A, additional

Published
2014
Full Text
View/download PDF

124. [123I]Iodometomidate imaging in adrenocortical carcinoma

Author

Kreissl, MC, primary, Schirbel, A, additional, Fassnacht, M, additional, Hänscheid, H, additional, Verburg, FA, additional, Bock, S, additional, Saeger, W, additional, Knödler, P, additional, Reiners, C, additional, Buck, AK, additional, Allolio, B, additional, and Hahner, S, additional

Published
2013
Full Text
View/download PDF

126. DG3173 (somatoprim), a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue, effectively reduces GH secretion in human GH-secreting pituitary adenomas even in Octreotide non-responsive tumours

Author

Plöckinger, U, primary, Hoffmann, U, additional, Geese, M, additional, Lupp, A, additional, Buchfelder, M, additional, Flitsch, J, additional, Vajkoczy, P, additional, Jakob, W, additional, Saeger, W, additional, Schulz, S, additional, and Dohrmann, C, additional

Published
2012
Full Text
View/download PDF

129. ADVANCES IN THE MEDICAL AND SURGICAL-TREATMENT OF PITUITARY- ADENOMAS - THE ROLE OF LONG-ACTING SOMATOSTATIN ANALOGS

Author

Fahlbusch, R, Giovanelli, M, Buchfelder, M, Losa, M, Andrioli, Gc, Anile, C, Billeci, D, Buonaguidi, R, Camboni, G, Carteri, A, Dennler, Hj, Faglia, G, Fraioli, B, Frank, G, Galli, G, Halves, E, Hey, O, Hildebrandt, G, Knosp, E, Landolt, Am, Liuzzi, A, Ludecke, Dk, Maira, G, Marini, G, Nicola, Gc, Oeckler, R, Plockinger, U, Quabbe, Hj, Renoldi, M, Saeger, W, Scanarini, M, Schramm, J, Sicolo, N, Spada, A, Spaziante, R, Steudel, Wi, Tomasello, Francesco, Vonwerder, K, Wiederhold, V, and Zimmermann, J.

Published
1993

148. Ultrastructural-morphometric effects of radiotherapy on pituitary adenomas in acromegaly

Author

Betzold Jm, Saeger W, and Lüdecke Dk

Subjects
Adenoma, medicine.medical_specialty, Pathology, Nucleolus, Endocrinology, Diabetes and Metabolism, Golgi Apparatus, Biology, Cytoplasmic Granules, Endoplasmic Reticulum, law.invention, Endocrinology, law, Fibrosis, Internal medicine, Acromegaly, Internal Medicine, medicine, Humans, Pituitary Neoplasms, Mitosis, Cell Nucleus, General Medicine, medicine.disease, Mitochondria, Microscopy, Electron, Ultrastructure, Electron microscope, Lysosomes, Reticulum, Intracellular, Cell Nucleolus
Abstract

Within a series of 22 irradiated GH-producing adenomas we studied by light microscopical and morphometrical means the grading of nuclear pleomorphism, the proportion of densely granulated cells, the number of mitoses, multinuclear cells, necrotic or necrobiotic cells, and the degree of fibrosis in comparison to non-irradiated tumours. By electronmicroscopical morphometry we investigated the changes in area, circumference, area percentage, and number of intracellular structures. The rate of necrobiotic cells and the grade of nuclear pleomorphism were significantly higher in the irradiated tumours. The fibrotic areas were larger. No differences were observed in the degree of granulation and the rate of multinuclear cells. Mitoses were found in only one tumour. Within the group of the well-differentiated adenomas the areas and circumferences of the nuclei, nucleoli, mitochondria, immature secretory granules, and secretory granules increased significantly. The area percentages of the nuclei, mitochondria, immature secretory granules, and secretory granules increased as well. The mitochondria, Golgi-fields, and the rough endoplasmatic reticulum decreased in number. The undifferentiated adenomas changed almost in the same significant way. To us most of these changes are a sign of irradiation damage. The enlargement of intracellular structures could be a sign of an increased rate of secretory activity.

Published
1992

Catalog

Books, media, physical & digital resources
See catalog results