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102. Effect of the plasticizer di-(2-ethylhexyl)phthalate on oxidative phosphorylation in rat liver mitochondria: modification of the function of the adenine nucleotide translocator.

Author

Kora S, Sado M, and Terada H

Subjects
Adenosine Diphosphate metabolism, Adenosine Triphosphate biosynthesis, Animals, Electron Transport drug effects, In Vitro Techniques, Male, Mitochondria, Liver metabolism, Oxygen Consumption drug effects, Rats, Rats, Inbred Strains, Diethylhexyl Phthalate pharmacology, Mitochondria, Liver drug effects, Mitochondrial ADP, ATP Translocases metabolism, Nucleotidyltransferases metabolism, Oxidative Phosphorylation drug effects, Phthalic Acids pharmacology
Abstract

The effect of di-(2-ethylhexyl)phthalate (DEHP) on oxidative phosphorylation of isolated rat liver mitochondria was investigated. DEHP at concentrations of 20-1000 microM had no effect on state 4 respiration, but at 40 microM, DEHP decreased the rate of state 3 respiration by about 20%. Although DEHP had no effect on electron transport through the respiratory chain, it decreased the rate of adenosine triphosphate (ATP) synthesis. Its inhibition of ATP synthesis showed a similar concentration dependence to that of state 3 respiration. Furthermore, DEHP at 40 microM inhibited the uptake of [3H]adenosine diphosphate into mitochondria. DEHP also retarded the action of cationic uncoupling agents, which are known to modify the 29000-dalton protein involved in adenine nucleotide exchange. These results suggest that DEHP affects the activity of adenine nucleotide exchange and consequently partially decreases the rate of state 3 respiration. The action of DEHP on the 29000-dalton protein involves a protective effect against mitochondrial damage induced by hydrophobic cations or heavy metal cations.

Published
1988
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103. A survey of infant mortality rates in Sarawak.

Author

Goto S, Sado M, Yano K, Takeuchi M, and Ichikawa Y

Subjects
Adolescent, Adult, Child, Child, Preschool, Female, Humans, Infant, Infant Nutritional Physiological Phenomena, Infant, Newborn, Malaysia, Maternal Age, Middle Aged, Mortality, Parity, Pregnancy, Pregnancy Complications, Rural Health, Socioeconomic Factors, Infant Mortality
Published
1974

106. [EUTROPHICS USED IN OBSTETRICS AND GYNECOLOGY].

Author

ASHIDAKA Y, TAKEMURA T, KAWABATA K, MINAMI Y, NISHIMURA Y, MIYAKE H, SADO M, and SAKAGUCHI S

Subjects
Animals, Female, Humans, Pregnancy, Rats, Amino Acids, Drug Therapy, Genital Diseases, Female, Gynecology, Nutritional Physiological Phenomena, Nutritional Sciences, Obstetrics, Pregnancy, Animal, Research, Vitamin A, Vitamin K, Vitamins
Published
1964

107. [Comparison between the effect of L-dopa and its methylated ester on cerebral dopamine and noradrenaline of rats exposed to oxypertin].

Author

Van den Driessche J, Sado M, Linée P, Lacroix P, Le Clec'h G, Delamaire J, and Patay M

Subjects
Administration, Oral, Animals, Antidepressive Agents pharmacology, Decarboxylation, Hydrogen-Ion Concentration, Indoles pharmacology, Methylation, Norepinephrine metabolism, Rats, Serotonin metabolism, Tranquilizing Agents pharmacology, Brain metabolism, Dihydroxyphenylalanine pharmacology, Dopamine metabolism
Published
1973

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