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112 results on '"Sabaredzovic A"'

103. Perfluoroalkyl substances and ovarian hormone concentrations in naturally cycling women

Author

Sally W. Thurston, Inger Thune, Peter T. Ellison, Susan F. Lipson, Azemira Sabaredzovic, Hanne Frydenberg, Emily S. Barrett, Chongshu Chen, Line Småstuen Haug, and Frøydis Nyborg Fjeldheim

Subjects
Adult, medicine.medical_specialty, Perfluorooctanesulfonic acid, Saliva, Time Factors, media_common.quotation_subject, Endocrine Disruptors, Luteal phase, Risk Assessment, Article, chemistry.chemical_compound, Internal medicine, Follicular phase, medicine, Humans, Ovulation, Menstrual Cycle, Progesterone, Menstrual cycle, media_common, Fluorocarbons, Estradiol, business.industry, Ovary, Obstetrics and Gynecology, Environmental Exposure, Environmental exposure, Parity, Endocrinology, Alkanesulfonic Acids, Reproductive Medicine, chemistry, Female, Cycling, business, Biomarkers
Abstract

Objective To examine associations between environmental exposure to perfluoroalkyl substances (PFASs) and ovarian hormone concentrations in naturally cycling women. Design E2 and P were measured in saliva samples collected daily for a single menstrual cycle and concentrations of PFASs (including perfluoroctane sulfonate [PFOS] and perfluoroctanoic acid) were measured in serum samples collected during the same cycle. Setting Not applicable. Patient(s) A total of 178 healthy, naturally cycling women, aged 25–35 years. Intervention(s) None. Main Outcome Measure(s) Mean follicular E 2 (cycle days −7 to −1, where 0 is the day of ovulation); mean luteal P (cycle days +2 to 10). Result(s) Among nulliparous, but not parous women, PFOS concentrations were inversely associated with E 2 (β = −0.025, 95% CI −0.043, −0.007) and P (β = −0.027, 95% CI −0.048, −0.007). Similar, but weaker results were observed for perfluorooctanesulfonic acid. No associations were observed between other PFASs (including perfluoroctanoic acid) and ovarian steroid concentrations, nor were any associations noted in parous women. Conclusion(s) Our results demonstrate that PFOS and perfluorooctanesulfonic acid may be associated with decreased production of E 2 and P in reproductive age women. These results suggest a possible mechanism by which PFASs affect women's health, and underscore the importance of parity in research on PFASs and women's reproductive health.

Published
2015

105. Perfluoroalkyl substances and lipid concentrations in plasma during pregnancy among women in the Norwegian Mother and Child Cohort Study

Author

Starling, Anne P., primary, Engel, Stephanie M., additional, Whitworth, Kristina W., additional, Richardson, David B., additional, Stuebe, Alison M., additional, Daniels, Julie L., additional, Haug, Line Småstuen, additional, Eggesbø, Merete, additional, Becher, Georg, additional, Sabaredzovic, Azemira, additional, Thomsen, Cathrine, additional, Wilson, Ralph E., additional, Travlos, Gregory S., additional, Hoppin, Jane A., additional, Baird, Donna D., additional, and Longnecker, Matthew P., additional

Published
2014
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106. Determinants of plasma concentrations of perfluoroalkyl substances in pregnant Norwegian women

Author

Brantsæter, A.L., primary, Whitworth, K.W., additional, Ydersbond, T.A., additional, Haug, L.S., additional, Haugen, M., additional, Knutsen, H.K., additional, Thomsen, C., additional, Meltzer, H.M., additional, Becher, G., additional, Sabaredzovic, A., additional, Hoppin, J.A., additional, Eggesbø, M., additional, and Longnecker, M.P., additional

Published
2013
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112. Associations between a mixture of phenols and phthalates and child behaviour in a French mother-child cohort with repeated assessment of exposure.

Author

Guilbert A, Rolland M, Pin I, Thomsen C, Sakhi AK, Sabaredzovic A, Slama R, Guichardet K, and Philippat C

Subjects
Child, Child Behavior, Environmental Exposure, Female, Humans, Male, Mother-Child Relations, Phenols toxicity, Pregnancy, Environmental Pollutants, Phthalic Acids toxicity
Abstract

Background: Synthetic phenols and phthalates can interfere with biological pathways involved in brain development. Despite the high within-subject temporal variability of urinary concentrations observed for their metabolites, studies investigating effects of phenols and phthalates on child behaviour often relied on a limited number of spot biospecimens to assess exposure. Besides, the majority did not consider mixture effects., Objectives: To study the combined effect of prenatal exposure to synthetic phenols and phthalates on child behaviour using repeated exposure measurements., Methods: We assessed concentrations of 12 phenols, 13 phthalate and 2 non-phthalate plasticizer metabolites in within-subject pools of multiple urine samples (median = 21 samples per individual pool) collected at two distinct time points during pregnancy in 416 mother-child pairs from the French SEPAGES cohort. Child behaviour was evaluated at two years using the Child Behaviour Checklist 1.5-5 (CBCL). Associations between a mixture of biomarkers of exposure and externalizing and internalizing behaviour scores were studied using adjusted Weighted Quantile Sum (WQS) regressions with a repeated holdout validation (100 repetitions)., Results: The positive WQS indexes were associated with both the externalizing and internalizing behaviour scores in the whole population, indicating greater risk of behavioural problems. Stratification for child sex suggested stronger associations in girls than boys. On average, girls externalizing and internalizing scores increased by 3.67 points (95% CI: 1.24, 6.10) and 2.47 points (95 %CI: 0.60, 4.33) respectively, for an increase of one tertile in the WQS index, compared with 1.70 points (95 %CI: -0.42, 3.81) and 1.17 points (95 %CI: -0.50, 2.84) in boys. Main contributors for the associations observed in girls were bisphenol A (weight of 18%), triclosan (17%) and monoethyl phthalate (MEP, 15%) for the externalizing score and MEP (19%), mono-benzyl phthalate (MBzP, 19%) and mono-n-butyl phthalate (MnBP, 16%) for the internalizing score., Discussion: Our results suggest adverse associations between in utero exposure to a mixture of phenols and phthalates and child behaviour, mainly in girls. Public health consequences may be substantial due to the widespread exposure of the population to these compounds., (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Published
2021
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