101. BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers
- Author
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Sébastien, Couraud, Pierre-Jean, Souquet, Christophe, Paris, Pascal, Dô, Hélène, Doubre, Eric, Pichon, Adrien, Dixmier, Isabelle, Monnet, Bénédicte, Etienne-Mastroianni, Michel, Vincent, Jean, Trédaniel, Marielle, Perrichon, Pascal, Foucher, Bruno, Coudert, Denis, Moro-Sibilot, Eric, Dansin, Stéphanie, Labonne, Pascale, Missy, Franck, Morin, Hélène, Blanché, Gérard, Zalcman, Laurence, Bigay-Game, Service de pneumologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), Hôpital Foch [Suresnes], Centre Hospitalier Régional d'Orléans (CHRO), Centre Hospitalier Intercommunal de Créteil (CHIC), Centre de Mise en Forme des Matériaux (CEMEF), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Unité de cancérologie thoracique [ESPIC Groupe hospitalier Paris Saint-Joseph], Université Paris Descartes - Paris 5 (UPD5)-Groupe Hospitalier Paris Saint Joseph, Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés (TRACES), École des hautes études en sciences sociales (EHESS)-Université Toulouse - Jean Jaurès (UT2J)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université Lille Nord de France (COMUE)-UNICANCER, Epidémiologie et Biostatistique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Intergroupe Francophone de Cancérologie Thoracique [Paris] (IFCT), Intergroupe Francophone de Cancérologie thoracique, Fondation Jean Dausset CEPH, Unité de génétique et biologie des cancers (U830), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Régional de Lutte contre le Cancer François Baclesse (CRLC François Baclesse ), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Régional d'Orléans (CHR), Centre National de la Recherche Scientifique (CNRS)-PSL Research University (PSL)-MINES ParisTech - École nationale supérieure des mines de Paris, Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc (CRLCC - CGFL), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Center Oscar Lambret, CRLCC Oscar Lambret, Université Paris Descartes - Paris 5 (UPD5)-Institut Curie-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Mines Paris - PSL (École nationale supérieure des mines de Paris), École des hautes études en sciences sociales (EHESS)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), and Université de Lille-UNICANCER
- Subjects
Male ,Lung Neoplasms ,Passive smoking ,Receptor, ErbB-2 ,medicine.disease_cause ,Cohort Studies ,0302 clinical medicine ,Risk Factors ,Surveys and Questionnaires ,Epidemiology ,Anaplastic Lymphoma Kinase ,ComputingMilieux_MISCELLANEOUS ,0303 health sciences ,Smoking ,Nuclear Proteins ,Middle Aged ,3. Good health ,ErbB Receptors ,Occupational Diseases ,[STAT]Statistics [stat] ,030220 oncology & carcinogenesis ,Biomarker (medicine) ,Female ,France ,KRAS ,Proto-Oncogene Proteins B-raf ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Proto-Oncogene Proteins p21(ras) ,03 medical and health sciences ,Sex Factors ,Occupational Exposure ,Internal medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Risk factor ,Lung cancer ,Pathological ,Aged ,030304 developmental biology ,business.industry ,Receptor Protein-Tyrosine Kinases ,medicine.disease ,Surgery ,Carcinogens ,Tobacco Smoke Pollution ,Observational study ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,Biomarkers ,Transcription Factors - Abstract
Lung cancer in never-smokers (LCINS) (fewer than 100 cigarettes in lifetime) is considered as a distinct entity and harbours an original molecular profile. However, the epidemiological and molecular features of LCINS in Europe remain poorly understood.All consecutive newly diagnosed LCINS patients were included in this prospective observational study by 75 participating centres during a 14-month period. Each patient completed a detailed questionnaire about risk factor exposure. Biomarker and pathological analyses were also collected. We report the main descriptive overall results with a focus on sex differences.384 patients were included: 65 men and 319 women. 66% had been exposed to passive smoking (significantly higher among women). Definite exposure to main occupational carcinogens was significantly higher in men (35%versus8% in women). A targetable molecular alteration was found in 73% of patients (without any significant sex difference):EGFRin 51%,ALKin 8%,KRASin 6%,HER2in 3%,BRAFin 3%,PI3KCAin less than 1%, and multiple in 2%.We present the largest and most comprehensive LCINS analysis in a European population. Physicians should track occupational exposure in men (35%), and a somatic molecular alteration in both sexes (73%).
- Published
- 2015
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