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68,176 results on '"Rojo A"'

104. Methylation marks in blood DNA reveal breast cancer risk in patients fulfilling hereditary disease criteria

Author

Ruiz-De La Cruz, Miguel, Martínez-Gregorio, Héctor, Estela Díaz-Velásquez, Clara, Ambriz-Barrera, Fernando, Resendiz-Flores, Norma Gabriela, Gitler-Weingarten, Rina, Rojo-Castillo, María Patricia, Pradda, Didier, Oliver, Javier, Perdomo, Sandra, Gómez-García, Eva María, De La Cruz-Montoya, Aldo Hugo, Terrazas, Luis Ignacio, Torres-Mejía, Gabriela, Hernández-Hernández, Fidel de la Cruz, and Vaca-Paniagua, Felipe

Published
2024
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106. Association between lipid profile and clinical outcomes in COVID-19 patients

Author

Ochoa-Ramírez, Luis Antonio, De la Herrán Arita, Alberto Kousuke, Sanchez-Zazueta, Jorge Guillermo, Ríos-Burgueño, Efrén, Murillo-Llanes, Joel, De Jesús-González, Luis Adrián, Farfan-Morales, Carlos Noe, Cordero-Rivera, Carlos Daniel, del Ángel, Rosa María, Romero-Utrilla, Alejandra, Camberos-Barraza, Josué, Valdez-Flores, Marco Antonio, Camacho-Zamora, Alejandro, Batiz-Beltrán, José Candelario, Angulo-Rojo, Carla, Guadrón-Llanos, Alma Marlene, Picos-Cárdenas, Verónica Judith, Norzagaray-Valenzuela, Claudia Desiree, Rábago-Monzón, Ángel Radamés, Velarde-Félix, Jesús Salvador, Reyes-Ruiz, José Manuel, and Osuna-Ramos, Juan Fidel

Published
2024
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115. Factors associated to the presence of headache in patients with influenza infection and its consequences: a 2010–2020 surveillance-based study

Author

García-Azorín, David, Santana-López, Laura, Lozano-Alonso, José Eugenio, Ordax-Díez, Ana, Vega-Alonso, Tomas, Macias Saint-Gerons, Diego, González-Osorio, Yésica, Rojo-Rello, Silvia, Eiros, José M., Sánchez-Martínez, Javier, Sierra-Mencía, Álvaro, Recio-García, Andrea, Martín-Toribio, Alejandro, Sanz-Muñoz, Ivan, and Guerrero-Peral, Ángel Luis

Published
2024
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116. NK cell-triggered CCL5/IFNγ-CXCL9/10 axis underlies the clinical efficacy of neoadjuvant anti-HER2 antibodies in breast cancer

Author

Santana-Hernández, Sara, Suarez-Olmos, Jesús, Servitja, Sonia, Berenguer-Molins, Pau, Costa-Garcia, Marcel, Comerma, Laura, Rea, Anna, Perera-Bel, Julia, Menendez, Silvia, Arpí, Oriol, Bermejo, Begoña, Martínez, María Teresa, Cejalvo, Juan Miguel, Comino-Méndez, Iñaki, Pascual, Javier, Alba, Emilio, López-Botet, Miguel, Rojo, Federico, Rovira, Ana, Albanell, Joan, and Muntasell, Aura

Published
2024
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119. Deontología profesional en Información Médica en la industria farmacéutica: en el camino hacia un código español de buenas prácticas

Author

Rojo Abril, Mónica

Subjects
Información médica, Buenas prácticas, Deontología profesional, Industria Farmacéutica, Bibliography. Library science. Information resources
Abstract

Introducción: En España, la Industria Farmacéutica es uno de los principales proveedores de Información Médica dentro del ámbito de la salud. En su compromiso con el servicio que proporcionan, los Técnicos de Información Médica (TIM) echan en falta un marco deontológico que guíe su actividad y garantice la calidad, la equidad y el equilibrio de la información que proporcionan a los profesionales sanitarios. Objetivo: En su camino hacia un código español de buenas prácticas, el Grupo de Trabajo de Información Médica de la Asociación de Medicina de la Industria Farmacéutica (AMIFE) quiere presentar a la comunidad profesional el marco deontológico en que se manifiesta su reflexión ética, así como establecer los puntos de partida sobre los que afronta la elaboración de un texto accesible a todos los profesionales del sector y a las empresas que proporcionan y respaldan sus actividades.

Published
2016
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120. Systematic Review and Meta-Analysis of the Relationship between Exposure to Parental Substance Use and Attention-Deficit/Hyperactivity Disorder in Children

Author

Brion S. Maher, Rebecca H. Bitsko, Angelika H. Claussen, Brenna O'Masta, Audrey Cerles, Joseph R. Holbrook, Zayan Mahmooth, Naomi Chen-Bowers, Ana L. Almeida Rojo, Jennifer W. Kaminski, and Margaret Rush

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is characterized by persistent patterns of inattention, hyperactivity, and impulsiveness. Among US children and adolescents aged 3-17 years, 9.4% have a diagnosis of ADHD. Previous research suggests possible links between parental substance use and ADHD among children. We conducted a systematic review and meta-analysis of 86 longitudinal or retrospective studies of prenatal or postnatal alcohol, tobacco, or other parental substance use and substance use disorders and childhood ADHD and its related behavioral dimensions of inattention and hyperactivity-impulsivity. Meta-analyses were grouped by drug class and pre- and postnatal periods with combined sample sizes ranging from 789 to 135,732. Prenatal exposure to alcohol or tobacco and parent substance use disorders were consistently and significantly associated with ADHD among children. Other parental drug use exposures resulted in inconsistent or non-significant findings. Prevention and treatment of parental substance use may have potential for impacts on childhood ADHD.

Published
2024
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121. Constraints on metastable superheavy dark matter coupled to sterile neutrinos with the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Campuzano, F., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., de Errico, B. P. de Souza, De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gaudu, C., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Jilek, V., Johnsen, J. A., Jurysek, J., Kampert, K. -H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Köhler, J., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mathes, H. -J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pereira, L. A. S., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Sedoski, A., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Strähnz, S., Straub, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.

Subjects
High Energy Physics - Phenomenology, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Dark matter particles could be superheavy, provided their lifetime is much longer than the age of the universe. Using the sensitivity of the Pierre Auger Observatory to ultra-high energy neutrinos and photons, we constrain a specific extension of the Standard Model of particle physics that meets the lifetime requirement for a superheavy particle by coupling it to a sector of ultra-light sterile neutrinos. Our results show that, for a typical dark coupling constant of 0.1, the mixing angle $\theta_m$ between active and sterile neutrinos must satisfy, roughly, $\theta_m \lesssim 1.5\times 10^{-6}(M_X/10^9~\mathrm{GeV})^{-2}$ for a mass $M_X$ of the dark-matter particle between $10^8$ and $10^{11}~$GeV., Comment: Version accepted for publication in PRD Letters, including Supplemental Material

Published
2023
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122. The intrinsic charm quark valence distribution of the proton

Author

Ball, Richard D., Candido, Alessandro, Cruz-Martinez, Juan, Forte, Stefano, Giani, Tommaso, Hekhorn, Felix, Magni, Giacomo, Nocera, Emanuele R., Rojo, Juan, and Stegeman, Roy

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

We provide a first quantitative indication that the wave function of the proton contains unequal distributions of charm quarks and antiquarks, i.e. a nonvanishing intrinsic valence charm distribution. A significant nonvanishing valence component cannot be perturbatively generated, hence our results reinforce previous evidence that the proton contains an intrinsic (i.e., not radiatively generated) charm quark component. We establish our result through a determination of the parton distribution functions (PDFs) of charm quarks and antiquarks in the proton. We propose two novel experimental probes of this intrinsic charm valence component: D-meson asymmetries in Z+c-jet production at the LHCb experiment, and flavor-tagged structure functions at the Electron-Ion Collider., Comment: 11 pages, 11 figures. PDF files available for download in LHAPDF format from https://nnpdf.mi.infn.it/nnpdf4-0-charm-asymmetry-study/ Final version, to be published in PRD (letters). Figures 2, 6 and 7 added. Fit without imposing the charm valence sum rule added. Various small clarifications

Published
2023

123. Radio Measurements of the Depth of Air-Shower Maximum at the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Anukriti, Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., de Errico, B. P. de Souza, De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gaudu, C., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Jilek, V., Johnsen, J. A., Jurysek, J., Kampert, K. -H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Köhler, J., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mathes, H. -J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pereira, L. A. S., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Strähnz, S., Straub, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Auger Engineering Radio Array (AERA), part of the Pierre Auger Observatory, is currently the largest array of radio antenna stations deployed for the detection of cosmic rays, spanning an area of $17$ km$^2$ with 153 radio stations. It detects the radio emission of extensive air showers produced by cosmic rays in the $30-80$ MHz band. Here, we report the AERA measurements of the depth of the shower maximum ($X_\text{max}$), a probe for mass composition, at cosmic-ray energies between $10^{17.5}$ to $10^{18.8}$ eV, which show agreement with earlier measurements with the fluorescence technique at the Pierre Auger Observatory. We show advancements in the method for radio $X_\text{max}$ reconstruction by comparison to dedicated sets of CORSIKA/CoREAS air-shower simulations, including steps of reconstruction-bias identification and correction, which is of particular importance for irregular or sparse radio arrays. Using the largest set of radio air-shower measurements to date, we show the radio $X_\text{max}$ resolution as a function of energy, reaching a resolution better than $15$ g cm$^{-2}$ at the highest energies, demonstrating that radio $X_\text{max}$ measurements are competitive with the established high-precision fluorescence technique. In addition, we developed a procedure for performing an extensive data-driven study of systematic uncertainties, including the effects of acceptance bias, reconstruction bias, and the investigation of possible residual biases. These results have been cross-checked with air showers measured independently with both the radio and fluorescence techniques, a setup unique to the Pierre Auger Observatory., Comment: Submitted to Phys. Rev. D

Published
2023

124. Demonstrating Agreement between Radio and Fluorescence Measurements of the Depth of Maximum of Extensive Air Showers at the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Anukriti, Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., de Errico, B. P. de Souza, De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gaudu, C., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Jilek, V., Johnsen, J. A., Jurysek, J., Kampert, K. -H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Köhler, J., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mathes, H. -J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pereira, L. A. S., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Strähnz, S., Straub, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We show, for the first time, radio measurements of the depth of shower maximum ($X_\text{max}$) of air showers induced by cosmic rays that are compared to measurements of the established fluorescence method at the same location. Using measurements at the Pierre Auger Observatory we show full compatibility between our radio and the previously published fluorescence data set, and between a subset of air showers observed simultaneously with both radio and fluorescence techniques, a measurement setup unique to the Pierre Auger Observatory. Furthermore, we show radio $X_\text{max}$ resolution as a function of energy and demonstrate the ability to make competitive high-resolution $X_\text{max}$ measurements with even a sparse radio array. With this, we show that the radio technique is capable of cosmic-ray mass composition studies, both at Auger and at other experiments., Comment: Submitted to Phys. Rev. Lett

Published
2023

125. Post-LS3 Experimental Options in ECN3

Author

Ahdida, C., Arduini, G., Balazs, K., Bartosik, H., Bernhard, J., Boyarsky, A., Brod, J., Brugger, M., Calviani, M., Ceccucci, A., Crivellin, A., D'Ambrosio, G., De Lellis, G., Döbrich, B., Fraser, M., Ximenes, R. Franqueira, Golutvin, A., Alonso, M. Gonzalez, Goudzovski, E., Grenard, J. -L., Heeck, J., Jaeckel, J., Jacobsson, R., Kadi, Y., Kahlhoefer, F., Kling, F., Koval, M., Lanfranchi, G., Lazzeroni, C., Mahmoudi, F., Marzocca, D., Massri, K., Moulson, M., Neshatpour, S., Osborne, J., Pospelov, M., Prebibaj, T., Rabemananjara, T. R., Rembser, Ch., Rojo, J., Rozanov, A., Ruggiero, G., Rumolo, G., Schnell, G., Schott, M., Soreq, Y., Spadaro, T., Vallée, C., Zickler, T., and Zupan, J.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

The Experimental Cavern North 3 (ECN3) is an underground experimental cavern on the CERN Pr\'evessin site. ECN3 currently hosts the NA62 experiment, with a physics programme devoted to rare kaon decays and searches of hidden particles approved until Long Shutdown 3 (LS3). Several options are proposed on the longer term in order to make best use of the worldwide unique potential of the high-intensity/high-energy proton beam extracted from the Super Proton Synchrotron (SPS) in ECN3. The current status of their study by the CERN Physics Beyond Colliders (PBC) Study Group is presented, including considerations on beam requirements and upgrades, detector R&D and construction, schedules and cost, as well as physics potential within the CERN and worldwide landscape., Comment: 113 pages, 39 figures

Published
2023

126. Ground observations of a space laser for the assessment of its in-orbit performance

Author

The Pierre Auger Collaboration, Lux, O., Krisch, I., Reitebuch, O., Huber, D., Wernham, D., Parrinello, T., Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Anukriti, Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Bwembya, A., Büsken, M., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., de Errico, B. P. de Souza, De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gaudu, C., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Gongora, J. P., González, J. M., González, N., Goos, I., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Berisso, M. Gómez, Vitale, P. F. Gómez, Góra, D., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Horvath, P., Hrabovský, M., Huege, T., Hörandel, J. R., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Kunka, N., Köhler, J., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Martins, M. A., Bravo, O. Martínez, Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pelayo, R., Pereira, L. A. S., Martins, E. E. Pereira, Armand, J. Perez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Bertolli, C. Pérez, Pękala, J., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Schäfer, C. M., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Strähnz, S., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Sánchez, F., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vlastimil, J., Vorobiov, S., Vásquez-Ramírez, A., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Atmospheric and Oceanic Physics, Physics - Optics
Abstract

The wind mission Aeolus of the European Space Agency was a groundbreaking achievement for Earth observation. Between 2018 and 2023, the space-borne lidar instrument ALADIN onboard the Aeolus satellite measured atmospheric wind profiles with global coverage which contributed to improving the accuracy of numerical weather prediction. The precision of the wind observations, however, declined over the course of the mission due to a progressive loss of the atmospheric backscatter signal. The analysis of the root cause was supported by the Pierre Auger Observatory in Argentina whose fluorescence detector registered the ultraviolet laser pulses emitted from the instrument in space, thereby offering an estimation of the laser energy at the exit of the instrument for several days in 2019, 2020 and 2021. The reconstruction of the laser beam not only allowed for an independent assessment of the Aeolus performance, but also helped to improve the accuracy in the determination of the laser beam's ground track on single pulse level. The results presented in this paper set a precedent for the monitoring of space lasers by ground-based telescopes and open new possibilities for the calibration of cosmic-ray observatories., Comment: 10 pages, 10 figures

Published
2023

127. On Two- and Three-valued Semantics for Impure Simplicial Complexes

Author

van Ditmarsch, Hans, Kuznets, Roman, and Randrianomentsoa, Rojo

Subjects
Computer Science - Distributed, Parallel, and Cluster Computing, Computer Science - Logic in Computer Science
Abstract

Simplicial complexes are a convenient semantic primitive to reason about processes (agents) communicating with each other in synchronous and asynchronous computation. Impure simplicial complexes distinguish active processes from crashed ones, in other words, agents that are alive from agents that are dead. In order to rule out that dead agents reason about themselves and about other agents, three-valued epistemic semantics have been proposed where, in addition to the usual values true and false, the third value stands for undefined: the knowledge of dead agents is undefined and so are the propositional variables describing their local state. Other semantics for impure complexes are two-valued where a dead agent knows everything. Different choices in designing a semantics produce different three-valued semantics, and also different two-valued semantics. In this work, we categorize the available choices by discounting the bad ones, identifying the equivalent ones, and connecting the non-equivalent ones via a translation. The main result of the paper is identifying the main relevant distinction to be the number of truth values and bridging this difference by means of a novel embedding from three- into two-valued semantics. This translation also enables us to highlight quite fundamental modeling differences underpinning various two- and three-valued approaches in this area of combinatorial topology. In particular, pure complexes can be defined as those invariant under the translation., Comment: In Proceedings GandALF 2023, arXiv:2309.17318

Published
2023
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128. The Pierre Auger Observatory Open Data

Author

The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Dourado, L. Andrade, Andringa, S., Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Campuzano, F., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Čermáková, B., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Errico, B., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farrar, G., Fauth, A. C., Fehler, T., Feldbusch, F., Fernandes, A., Fick, B., Figueira, J. M., Filip, P., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Freitas, M., Fujii, T., Fuster, A., Galea, C., García, B., Gaudu, C., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Góra, D., Gorgi, A., Gottowik, M., Guarino, F., Guedes, G. P., Guido, E., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Jilek, V., Jurysek, J., Kampert, K. -H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Köhler, J., Krieger, F., Kubatova, M., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lundquist, J. P., Payeras, A. Machado, Mandat, D., Manning, B. C., Mantsch, P., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mathes, H. -J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pelgrims, V., Pereira, L. A. S., Martins, E. E. Pereira, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reuzki, A., Ridky, J., Riehn, F., Risse, M., Rizi, V., Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Sampathkumar, P., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Sedoski, A., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Strähnz, S., Straub, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Tueros, M., Unger, M., Uzeiroska, R., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vašíčková, V., Vásquez-Ramírez, A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Weitz, M., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Pierre Auger Collaboration has embraced the concept of open access to their research data since its foundation, with the aim of giving access to the widest possible community. A gradual process of release began as early as 2007 when 1% of the cosmic-ray data was made public, along with 100% of the space-weather information. In February 2021, a portal was released containing 10% of cosmic-ray data collected from 2004 to 2018, during Phase I of the Observatory. The Portal included detailed documentation about the detection and reconstruction procedures, analysis codes that can be easily used and modified and, additionally, visualization tools. Since then the Portal has been updated and extended. In 2023, a catalog of the 100 highest-energy cosmic-ray events examined in depth has been included. A specific section dedicated to educational use has been developed with the expectation that these data will be explored by a wide and diverse community including professional and citizen-scientists, and used for educational and outreach initiatives. This paper describes the context, the spirit and the technical implementation of the release of data by the largest cosmic-ray detector ever built, and anticipates its future developments., Comment: 27 pages, 8 figures

Published
2023

129. The LHC as a Neutrino-Ion Collider

Author

Cruz-Martinez, Juan M., Fieg, Max, Giani, Tommaso, Krack, Peter, Mäkelä, Toni, Rabemananjara, Tanjona, and Rojo, Juan

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, Nuclear Experiment, Nuclear Theory
Abstract

Proton-proton collisions at the LHC generate a high-intensity collimated beam of neutrinos in the forward (beam) direction, characterised by energies of up to several TeV. The recent observation of LHC neutrinos by FASER$\nu$ and SND@LHC signals that this hitherto ignored particle beam is now available for scientific inquiry. Here we quantify the impact that neutrino deep-inelastic scattering (DIS) measurements at the LHC would have on the parton distributions (PDFs) of protons and heavy nuclei. We generate projections for DIS structure functions for FASER$\nu$ and SND@LHC at Run III, as well as for the FASER$\nu$2, AdvSND, and FLArE experiments to be hosted at the proposed Forward Physics Facility (FPF) operating concurrently with the High-Luminosity LHC (HL-LHC). We determine that up to one million electron- and muon-neutrino DIS interactions within detector acceptance can be expected by the end of the HL-LHC, covering a kinematic region in $x$ and $Q^2$ overlapping with that of the Electron-Ion Collider. Including these DIS projections into global (n)PDF analyses, specifically PDF4LHC21, NNPDF4.0, and EPPS21, reveals a significant reduction of PDF uncertainties, in particular for strangeness and the up and down valence PDFs. We show that LHC neutrino data enables improved theoretical predictions for core processes at the HL-LHC, such as Higgs and weak gauge boson production. Our analysis demonstrates that exploiting the LHC neutrino beam effectively provides CERN with a "Neutrino-Ion Collider" without requiring modifications in its accelerator infrastructure., Comment: 42 pages, 22 figures. Added detailed studies on fluxes uncertainties

Published
2023

130. AugerPrime Surface Detector Electronics

Author

The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Anukriti, Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Bwembya, A., Büsken, M., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., de Errico, B. P. de Souza, De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gaudu, C., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Gongora, J. P., González, J. M., González, N., Goos, I., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Berisso, M. Gómez, Vitale, P. F. Gómez, Góra, D., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Horvath, P., Hrabovský, M., Huege, T., Hörandel, J. R., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Martins, M. A., Bravo, O. Martínez, Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pelayo, R., Pereira, L. A. S., Martins, E. E. Pereira, Armand, J. Perez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Bertolli, C. Pérez, Pękala, J., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Schäfer, C. M., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Simon, F., Smau, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Strähnz, S., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Sánchez, F., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vlastimil, J., Vorobiov, S., Vásquez-Ramírez, A., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., and Šmída, R.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Operating since 2004, the Pierre Auger Observatory has led to major advances in our understanding of the ultra-high-energy cosmic rays. The latest findings have revealed new insights that led to the upgrade of the Observatory, with the primary goal of obtaining information on the primary mass of the most energetic cosmic rays on a shower-by-shower basis. In the framework of the upgrade, called AugerPrime, the 1660 water-Cherenkov detectors of the surface array are equipped with plastic scintillators and radio antennas, allowing us to enhance the composition sensitivity. To accommodate new detectors and to increase experimental capabilities, the electronics is also upgraded. This includes better timing with up-to-date GPS receivers, higher sampling frequency, increased dynamic range, and more powerful local processing of the data. In this paper, the design characteristics of the new electronics and the enhanced dynamic range will be described. The manufacturing and test processes will be outlined and the test results will be discussed. The calibration of the SD detector and various performance parameters obtained from the analysis of the first commissioning data will also be presented.

Published
2023

131. The automation of SMEFT-Assisted Constraints on UV-Complete Models

Author

ter Hoeve, Jaco, Magni, Giacomo, Rojo, Juan, Rossia, Alejo N., and Vryonidou, Eleni

Subjects
High Energy Physics - Phenomenology
Abstract

The ongoing Effective Field Theory (EFT) program at the LHC and elsewhere is motivated by streamlining the connection between experimental data and UV-complete scenarios of heavy new physics beyond the Standard Model (BSM). This connection is provided by matching relations mapping the Wilson coefficients of the EFT to the couplings and masses of UV-complete models. Building upon recent work on the automation of tree-level and one-loop matching in the SMEFT, we present a novel strategy automating the constraint-setting procedure on the parameter space of general heavy UV-models matched to dimension-six SMEFT operators. A new Mathematica package, match2fit, interfaces Matchmakereft, which derives the matching relations for a given UV model, and SMEFiT, which provides bounds on the Wilson coefficients by comparing with data. By means of this pipeline and using both tree-level and one-loop matching, we derive bounds on a wide range of single- and multi-particle extensions of the SM from a global dataset composed by LHC and LEP measurements. Whenever possible, we benchmark our results with existing studies. Our framework realises one of the main objectives of the EFT program in particle physics: deploying the SMEFT to bypass the need of directly comparing the predictions of heavy UV models with experimental data., Comment: 29+16 pages, 15 figures, 4 appendices. Open-source code is available on http://lhcfitnikhef.github.io/smefit_release/ and http://github.com/arossia94/match2fit

Published
2023

132. Universal composite boson formation in strongly interacting one-dimensional fermionic systems

Author

Sabater, Francesc, Rojo-Francàs, Abel, Astrakharchik, Grigori E., and Juliá-Díaz, Bruno

Subjects
Condensed Matter - Quantum Gases
Abstract

Attractive $p$-wave one-dimensional fermions are studied in the fermionic Tonks-Girardeau regime in which the diagonal properties are shared with those of an ideal Bose gas. We study the off-diagonal properties and present analytical expressions for the eigenvalues of the one-body density matrix. One striking aspect is the universality of the occupation numbers which are independent of the specific shape of the external potential. We show that the occupation of natural orbitals occurs in pairs, indicating the formation of composite bosons, each consisting of two attractive fermions. The formation of composite bosons sheds light on the pairing mechanism of the system orbitals, yielding a total density equal to that of a Bose-Einstein condensate., Comment: 7 pages, 4 figures

Published
2023
Full Text
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133. The Human Phenotype Ontology in 2024: phenotypes around the world

Author

Gargano, Michael A, Matentzoglu, Nicolas, Coleman, Ben, Addo-Lartey, Eunice B, Anagnostopoulos, Anna V, Anderton, Joel, Avillach, Paul, Bagley, Anita M, Bakštein, Eduard, Balhoff, James P, Baynam, Gareth, Bello, Susan M, Berk, Michael, Bertram, Holli, Bishop, Somer, Blau, Hannah, Bodenstein, David F, Botas, Pablo, Boztug, Kaan, Čady, Jolana, Callahan, Tiffany J, Cameron, Rhiannon, Carbon, Seth J, Castellanos, Francisco, Caufield, J Harry, Chan, Lauren E, Chute, Christopher G, Cruz-Rojo, Jaime, Dahan-Oliel, Noémi, Davids, Jon R, de Dieuleveult, Maud, de Souza, Vinicius, de Vries, Bert BA, de Vries, Esther, DePaulo, J Raymond, Derfalvi, Beata, Dhombres, Ferdinand, Diaz-Byrd, Claudia, Dingemans, Alexander JM, Donadille, Bruno, Duyzend, Michael, Elfeky, Reem, Essaid, Shahim, Fabrizzi, Carolina, Fico, Giovanna, Firth, Helen V, Freudenberg-Hua, Yun, Fullerton, Janice M, Gabriel, Davera L, Gilmour, Kimberly, Giordano, Jessica, Goes, Fernando S, Moses, Rachel Gore, Green, Ian, Griese, Matthias, Groza, Tudor, Gu, Weihong, Guthrie, Julia, Gyori, Benjamin, Hamosh, Ada, Hanauer, Marc, Hanušová, Kateřina, He, Yongqun, Hegde, Harshad, Helbig, Ingo, Holasová, Kateřina, Hoyt, Charles Tapley, Huang, Shangzhi, Hurwitz, Eric, Jacobsen, Julius OB, Jiang, Xiaofeng, Joseph, Lisa, Keramatian, Kamyar, King, Bryan, Knoflach, Katrin, Koolen, David A, Kraus, Megan L, Kroll, Carlo, Kusters, Maaike, Ladewig, Markus S, Lagorce, David, Lai, Meng-Chuan, Lapunzina, Pablo, Laraway, Bryan, Lewis-Smith, David, Li, Xiarong, Lucano, Caterina, Majd, Marzieh, Marazita, Mary L, Martinez-Glez, Victor, McHenry, Toby H, McInnis, Melvin G, McMurry, Julie A, Mihulová, Michaela, Millett, Caitlin E, Mitchell, Philip B, Moslerová, Veronika, Narutomi, Kenji, Nematollahi, Shahrzad, and Nevado, Julian

Subjects
Biological Sciences, Genetics, Human Genome, Machine Learning and Artificial Intelligence, Networking and Information Technology R&D (NITRD), 4.1 Discovery and preclinical testing of markers and technologies, Generic health relevance, Good Health and Well Being, Humans, Biological Ontologies, Phenotype, Genomics, Algorithms, Rare Diseases, Environmental Sciences, Information and Computing Sciences, Developmental Biology, Biological sciences, Chemical sciences, Environmental sciences
Abstract

The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity and machine learning algorithms. The HPO has widespread applications in clinical diagnostics and translational research, including genomic diagnostics, gene-disease discovery, and cohort analytics. In recent years, groups around the world have developed translations of the HPO from English to other languages, and the HPO browser has been internationalized, allowing users to view HPO term labels and in many cases synonyms and definitions in ten languages in addition to English. Since our last report, a total of 2239 new HPO terms and 49235 new HPO annotations were developed, many in collaboration with external groups in the fields of psychiatry, arthrogryposis, immunology and cardiology. The Medical Action Ontology (MAxO) is a new effort to model treatments and other measures taken for clinical management. Finally, the HPO consortium is contributing to efforts to integrate the HPO and the GA4GH Phenopacket Schema into electronic health records (EHRs) with the goal of more standardized and computable integration of rare disease data in EHRs.

Published
2024

134. The LHC as a Neutrino-Ion Collider

Author

Cruz-Martinez, Juan M, Fieg, Max, Giani, Tommaso, Krack, Peter, Mäkelä, Toni, Rabemananjara, Tanjona R, and Rojo, Juan

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Astronomical sciences, Atomic, molecular and optical physics, Particle and high energy physics
Abstract

Abstract: Proton-proton collisions at the LHC generate a high-intensity collimated beam of neutrinos in the forward (beam) direction, characterised by energies of up to several TeV. The recent observation of LHC neutrinos by FASER$$u $$ ν and SND@LHC signifies that this previously overlooked particle beam is now available for scientific investigation. Here we quantify the impact that neutrino deep-inelastic scattering (DIS) measurements at the LHC would have on the parton distributions (PDFs) of protons and heavy nuclei. We generate projections for DIS structure functions for FASER$$u $$ ν and SND@LHC at Run III, as well as for the FASER$$u $$ ν 2, AdvSND, and FLArE experiments to be hosted at the proposed Forward Physics Facility (FPF) operating concurrently with the High-Luminosity LHC (HL-LHC). We determine that up to one million electron-neutrino and muon-neutrino DIS interactions within detector acceptance can be expected by the end of the HL-LHC, covering a kinematic region in x and $$Q^2$$ Q 2 overlapping with that of the Electron-Ion Collider. Including these DIS projections in global (n)PDF analyses, specifically PDF4LHC21, NNPDF4.0, and EPPS21, reveals a significant reduction in PDF uncertainties, in particular for strangeness and the up and down valence PDFs. We show that LHC neutrino data enable improved theoretical predictions for core processes at the HL-LHC, such as Higgs and weak gauge boson production. Our analysis demonstrates that exploiting the LHC neutrino beam effectively provides CERN with a “Neutrino-Ion Collider” without requiring modifications in its accelerator infrastructure.

Published
2024

135. ReIGNITE Radiation Therapy Boost: A Prospective, International Study of Radiation Oncologists’ Accuracy in Contouring Prostate Tumors for Focal Radiation Therapy Boost on Conventional Magnetic Resonance Imaging Alone or With Assistance of Restriction Spectrum Imaging

Author

Lui, Asona J, Kallis, Karoline, Zhong, Allison Y, Hussain, Troy S, Conlin, Christopher, Digma, Leonardino A, Phan, Nikki, Mathews, Ian T, Do, Deondre D, Domingo, Mariluz Rojo, Karunamuni, Roshan, Kuperman, Joshua, Dale, Anders M, Shabaik, Ahmed, Rakow-Penner, Rebecca, Hahn, Michael E, and Seibert, Tyler M

Subjects
Medical and Biological Physics, Biomedical and Clinical Sciences, Clinical Sciences, Physical Sciences, Oncology and Carcinogenesis, Prostate Cancer, Radiation Oncology, Cancer, Aging, Urologic Diseases, Biomedical Imaging, Clinical Research, 4.2 Evaluation of markers and technologies, Male, Humans, Prospective Studies, Radiotherapy Planning, Computer-Assisted, Radiation Oncologists, Magnetic Resonance Imaging, Prostatic Neoplasms, Other Physical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis, Theoretical and computational chemistry, Medical and biological physics
Abstract

PurposeIn a phase III randomized trial, adding a radiation boost to tumor(s) visible on MRI improved prostate cancer (PCa) disease-free and metastasis-free survival without additional toxicity. Radiation oncologists' ability to identify prostate tumors is critical to widely adopting intraprostatic tumor radiotherapy boost for patients. A diffusion MRI biomarker, called the Restriction Spectrum Imaging restriction score (RSIrs), has been shown to improve radiologists' identification of clinically significant PCa. We hypothesized that (1) radiation oncologists would find accurately delineating PCa tumors on conventional MRI challenging and (2) using RSIrs maps would improve radiation oncologists' accuracy for PCa tumor delineation.Methods and materialsIn this multi-institutional, international, prospective study, 44 radiation oncologists (participants) and 2 expert radiologists (experts) contoured prostate tumors on 39 total patient cases using conventional MRI with or without RSIrs maps. Participant volumes were compared to the consensus expert volumes. Contouring accuracy metrics included percent overlap with expert volume, Dice coefficient, conformal number, and maximum distance beyond expert volume.Results1604 participant volumes were produced. 40 of 44 participants (91%) completely missed ≥1 expert-defined target lesion without RSIrs, compared to 13 of 44 (30%) with RSIrs maps. On conventional MRI alone, 134 of 762 contour attempts (18%) completely missed the target, compared to 18 of 842 (2%) with RSIrs maps. Use of RSIrs maps improved all contour accuracy metrics by approximately 50% or more. Mixed effects modeling confirmed that RSIrs maps were the main variable driving improvement in all metrics. System Usability Scores indicated RSIrs maps significantly improved the contouring experience (72 vs. 58, p

Published
2023

136. Low Human Papillomavirus Vaccination in a Low-Income Urban Population

Author

Rojo, Elizabeth M, Taylor, Kelly D, and McFarland, Willi

Subjects
Public Health, Health Sciences, Cancer, Immunization, HPV and/or Cervical Cancer Vaccines, Vaccine Related, Women's Health, Sexually Transmitted Infections, Infectious Diseases, Prevention, HIV/AIDS, 3.4 Vaccines, Infection, Good Health and Well Being, Male, Humans, Female, Papillomavirus Infections, Human Papillomavirus Viruses, Urban Population, Papillomavirus Vaccines, Vaccination, Health Knowledge, Attitudes, Practice, human papillomavirus, HPV vaccine, low-income, health disparities, Medical and Health Sciences, Education, Psychology and Cognitive Sciences, Public health, Applied and developmental psychology
Abstract

Despite widespread availability of human papillomavirus (HPV) vaccines and recommendations for routine use, awareness and uptake of HPV vaccination are not universal. We assessed self-reported history of HPV vaccination in a sample of low-income men and women recruited from the community using respondent-driven sampling as part of the National HIV Behavioral Surveillance (NHBS) survey in San Francisco. Of the 384 respondents, a minority (12.5%) reported they had received the HPV vaccine. In multivariate analysis, independent associations with HPV vaccination history were female sex (adjusted odds ratio [AOR] = 3.76, 95% confidence interval [CI] = [1.73, 8.17]), younger age (AOR = 0.89 per year, 95% CI = [0.86, 0.92]), and education above high school (AOR = 2.84, 95% CI = [1.37, 5.90]). Missed opportunities for HPV vaccination were evident in 84.4% of respondents having visited a health care provider in the last year, including 40.1% tested for a sexually transmitted infection, and entry into higher education programs (33.4%).

Published
2023

145. Ètica de la informació mèdica en la indústria farmacèutica : recomanacions a partir de la primera

Author

Rojo Abril, Mónica and Guardiola, Elena

Subjects
Asociación de Medicina de la Industria Farmacéutica en España, Medical sciences, Guides, Information law, Professional deontology, Bibliography. Library science. Information resources, Communication. Mass media, P87-96
Abstract

Objectiu: a manca d'una legislació específica, el Grupo de Trabajo de Información Médica de la Asociación de Medicina de la Industria Farmacéutica en España es va plantejar la importància de definir i orientar les obligacions i les activitats d'informació mèdica en la indústria farmacèutica. Tot i que hi ha algunes guies internacionals, es va considerar imprescindible elaborar una guia espanyola de bones pràctiques per a empreses i professionals, i alhora compartir amb la comunitat mèdica, els pacients i el públic en general els estàndards de qualitat que regeixen la informació mèdica en la indústria farmacèutica. -- Metodologia: durant una reunió ordinària, es van convidar els membres a participar en el projecte, fos en la planificació, la redacció, l'avaluació d'experts o l'edició dels capítols; d'entre els membres, es van triar dos coordinadors. Es van consensuar els temes que s'havien d'abordar i es va establir l'estructura dels capítols. Cada capítol havia d'incloure una revisió exhaustiva del tema i observacions o conclusions, que donarien lloc a les recomanacions finals. Després d'establir un índex inicial, es van sol·licitar autors voluntaris per fer-ne la redacció, i es van triar d'acord amb la seva experiència i el seu camp principal d'interès. Quan es va disposar dels capítols redactats, els coordinadors van designar dos membres del grup de treball per fer la revisió de cada capítol, amb la finalitat de detectar-hi mancances o errors de contingut i forma. Els coordinadors van fer una segona revisió per assegurar la consistència de l'obra, en van extreure les conclusions i les recomanacions, les van sotmetre a la revisió i la votació dels membres del grup de treball i van fer l'edició final dels textos. -- Resultats: es va redactar la Guía de buenas prácticas de información médica en la industria farmacéutica española. En els dotze capítols que la formen es van revisar la funció i la importància de la informació mèdica, les característiques i les activitats dels departaments d'informació mèdica, la formació i la qualificació dels seus professionals i els procediments normalitzats de treball, com també el marc legal i ètic en què es mou, la legislació sobre propietat intel·lectual, el paper de la medicina basada en l'evidència, la importància de l'avaluació de la qualitat, i els reptes de la informació mèdica amb vista al futur. Es van consensuar quinze recomanacions o conclusions. Objectives: In the absence of specific legislation, the Work Group on Medicines Information of the Medicines Association of the Spanish Pharmaceutical Industry (Asociación de Medicina de la Industria Farmacéutica, AMIFE) decided to define and delimit the obligations involved in managing medicines information in the pharmaceutical industry. Although certain international guides are currently available, it was considered necessary to write a Spanish guide that could be used by pharmaceutical companies and professionals and whose demands for quality standards in the sector could also be shared with the medical community, patients and the public at large. -- Methodology: In the course of one of the Group's regular meetings, group members were invited to participate in one of the project areas, which were the planning, write-up, evaluation of experts and publication of the guide in chapters. After choosing two project coordinators, the members agreed on the subjects to be covered and established the structure for the chapters. It was decided that each chapter should include a comprehensive review of a subject and observations or conclusions that would form the basis for a series of recommendations After drafting an initial table of contents, the group invited a series of professionals to work as voluntary authors, selecting these on the basis of their experience and main field of interest. When the authors had completed the first draft of the chapters, the Group coordinators appointed two members of the group to review each chapter and check it for missing information or errors of content or form. The coordinators then reviewed the chapters themselves to ensure the consistency of the overall guide and drew up conclusions and recommendations that were reviewed by the rest of the group and voted in or out of the final document. -- Results: The result was the Guía de buenas prácticas de información médica en la industria farmacéutica española. The twelve chapters comprising the guide reviewed the functions and importance of medicines information, the features and activities of the different areas of medicines information, the training and qualification frameworks of medicines information professionals, standard work procedures and the legal and ethical frameworks informing these, legislation on intellectual property rights, the importance of the role of evidence-based medicine and of quality assurance and the challenges that medicines information will have to face in the future. Fifteen conclusions or recommendations were also made at the end of the document.

Published
2017
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146. The chiral knife edge: a simplified rattleback to illustrate spin inversion

Author

Jagla, Eduardo A. and Rojo, Alberto G.

Subjects
Physics - Popular Physics
Abstract

We present the chiral knife edge rattleback, an alternative version of previously presented systems that exhibit spin inversion. We offer a full treatment of the model using qualitative arguments, analytical solutions as well as numerical results. We treat a reduced, one--mode problem which not only contains the essence of the physics of spin inversion, but that also exhibits an unexpected connection to the Chaplygin sleigh, providing new insight into the non-holonomic structure of the problem. We also present exact results for the full problem together with estimates of the time between inversions that agree with previous results in the literature.

Published
2023

147. Search for UHE Photons from Gravitational Wave Sources with the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Caccianiga, L., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Contreras, F., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Ebr, J., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Müller, A. L., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pereira, L. A. S., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shavar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suárez-Durán, M., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, General Relativity and Quantum Cosmology
Abstract

A search for time-directional coincidences of ultra-high-energy (UHE) photons above 10 EeV with gravitational wave (GW) events from the LIGO/Virgo runs O1 to O3 is conducted with the Pierre Auger Observatory. Due to the distinctive properties of photon interactions and to the background expected from hadronic showers, a subset of the most interesting GW events is selected based on their localization quality and distance. Time periods of 1000 s around and 1 day after the GW events are analyzed. No coincidences are observed. Upper limits on the UHE photon fluence from a GW event are derived that are typically at $\sim$7 MeV cm$^{-2}$ (time period 1000~s) and $\sim$35 MeV cm$^{-2}$ (time period 1 day). Due to the proximity of the binary neutron star merger GW170817, the energy of the source transferred into UHE photons above 40 EeV is constrained to be less than 20% of its total gravitational wave energy. These are the first limits on UHE photons from GW sources., Comment: 15 pages

Published
2023
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148. Atmospheric composition of WASP-85Ab with ESPRESSO/VLT observations

Author

Jiang, Zewen, Wang, Wei, Chen, Guo, Yan, Fei, Cegla, Heather M., Rojo, Patricio, Shi, Yaqing, Ouyang, Qinlin, Zhai, Meng, Liu, Yujuan, Zhao, Fei, and Chen, Yuqin

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Transit spectroscopy is the most frequently used technique to reveal the atmospheric properties of exoplanets, while that at high resolution has the advantage to resolve the small Doppler shift of spectral lines, and the trace signal of the exoplanet atmosphere can be separately extracted. We obtain the transmission spectra of the extrasolar planet WASP-85Ab, a hot Jupiter in a 2.655-day orbit around a G5, V=11.2 mag host star, observed by high-resolution spectrograph ESPRESSO at the Very Large Telescope array for three transits. We present an analysis of the Rossiter-McLaughlin effect on WASP-85A, and determine a spin-orbit angle ${\lambda = -16.155^{\circ}}^{+2.916}_{-2.879}$, suggesting that the planet is in an almost aligned orbit. Combining the transmission spectra of three nights, we tentatively detected H$\alpha$ and Ca II absorption with $\gtrapprox 3\sigma$ via direct visual inspection of the transmission spectra with the Center-to-Limb variation and the Rossiter-McLaughlin effects removed, which still remain visible after excluding the cores of these strong lines with a 0.1 A mask. These spectral signals seems likely to origin from the planetary atmosphere, but we can not fully exclude their stellar origins. Via the cross-correlation analysis of a set of atoms and molecules, Li I is marginally detected at $\sim4\sigma$ level, suggesting that Li might be present in the atmosphere of WASP-85Ab., Comment: Accepted for publication in A&A. 18 pages, 17 figures

Published
2023
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149. Strong Interaction Physics at the Luminosity Frontier with 22 GeV Electrons at Jefferson Lab

Author

Accardi, A., Achenbach, P., Adhikari, D., Afanasev, A., Akondi, C. S., Akopov, N., Albaladejo, M., Albataineh, H., Albrecht, M., Almeida-Zamora, B., Amaryan, M., Androić, D., Armstrong, W., Armstrong, D. S., Arratia, M., Arrington, J., Asaturyan, A., Austregesilo, A., Avagyan, H., Averett, T., Gayoso, C. Ayerbe, Bacchetta, A., Balantekin, A. B., Baltzell, N., Barion, L., Barry, P. C., Bashir, A., Battaglieri, M., Bellini, V., Belov, I., Benhar, O., Benkel, B., Benmokhtar, F, Bentz, W., Bertone, V., Bhatt, H., Bianconi, A., Bibrzycki, L., Bijker, R., Binosi, D., Biswas, D., Boër, M., Boeglin, W., Bogacz, S. A., Boglione, M., Bondí, M., Boos, E. E., Bosted, P., Bozzi, G., Brash, E. J., Briceño, R. A., Brindza, P. D., Briscoe, W. J., Brodsky, S. J, Brooks, W. K., Burkert, V. D., Camsonne, A., Cao, T., Cardman, L. S., Carman, D. S., Carpinelli, M, Cates, G. D., Caylor, J., Celentano, A., Celiberto, F. G., Cerutti, M., Chang, Lei, Chatagnon, P., Chen, C., Chen, J-P, Chetry, T., Christopher, A., Christy, E., Chudakov, E., Cisbani, E., Cloët, I. C., Cobos-Martinez, J. J., Cohen, E. O., Colangelo, P., Cole, P. L., Constantinou, M., Contalbrigo, M., Costantini, G., Cosyn, W., Cotton, C., Courtoy, A., Dusa, S. Covrig, Crede, V., Cui, Z. -F., D'Angelo, A., Döring, M., Dalton, M. M., Danilkin, I., Davydov, M., Day, D., De Fazio, F., De Napoli, M., De Vita, R., Dean, D. J., Defurne, M., Deur, A., Devkota, B., Dhital, S., Di Nezza, P., Diefenthaler, M., Diehl, S., Dilks, C., Ding, M., Djalali, C., Dobbs, S., Dupré, R., Dutta, D., Edwards, R. G., Egiyan, H., Ehinger, L., Eichmann, G., Elaasar, M., Elouadrhiri, L., Alaoui, A. El, Fassi, L. El, Emmert, A., Engelhardt, M., Ent, R., Ernst, D. J, Eugenio, P., Evans, G., Fanelli, C., Fegan, S., Fernández-Ramírez, C., Fernandez, L. A., Fernando, I. P., Filippi, A., Fischer, C. S., Fogler, C., Fomin, N., Frankfurt, L., Frederico, T., Freese, A., Fu, Y., Gamberg, L., Gan, L., Gao, F., Garcia-Tecocoatzi, H., Gaskell, D., Gasparian, A., Gates, K, Gavalian, G., Ghoshal, P. K., Giachino, A., Giacosa, F., Giannuzzi, F., Gilfoyle, G. -P., Girod, F-X, Glazier, D. I., Gleason, C., Godfrey, S., Goity, J. L., Golubenko, A. A., Gonzàlez-Solís, S., Gothe, R. W., Gotra, Y., Griffioen, K., Grocholski, O., Grube, B., Guèye, P., Guo, F. -K., Guo, Y., Guo, L., Hague, T. J., Hammoud, N., Hansen, J. -O., Hattawy, M., Hauenstein, F., Hayward, T., Heddle, D., Heinrich, N., Hen, O., Higinbotham, D. W., Higuera-Angulo, I. M., Blin, A. N. Hiller, Hobart, A., Hobbs, T., Holmberg, D. E, Horn, T., Hoyer, P., Huber, G. M., Hurck, P., Hutauruk, P. T. P., Ilieva, Y., Illari, I., Ireland, D. G, Isupov, E. L., Italiano, A., Jaegle, I., Jarvis, N. S., Jenkins, DJ, Jeschonnek, S., Ji, C-R., Jo, H. S., Jones, M., Jones, R. T., Jones, D. C., Joo, K., Junaid, M., Kageya, T., Kalantarians, N., Karki, A., Karyan, G., Katramatou, A. T., Kay, S. J. D, Kazimi, R., Keith, C. D., Keppel, C., Kerbizi, A., Khachatryan, V., Khanal, A., Khandaker, M., Kim, A., Kinney, E. R., Kohl, M., Kotzinian, A., Kriesten, B. T., Kubarovsky, V., Kubis, B., Kuhn, S. E., Kumar, V., Kutz, T., Leali, M., Lebed, R. F., Lenisa, P., Leskovec, L., Li, S., Li, X., Liao, J., Lin, H. -W., Liu, L., Liuti, S., Liyanage, N., Lu, Y., MacGregor, I. J. D., Mack, D. J., Maiani, L, Mamo, K. A., Mandaglio, G., Mariani, C., Markowitz, P., Marukyan, H., Mascagna, V., Mathieu, V., Maxwell, J., Mazouz, M., McCaughan, M., McKeown, R. D., McKinnon, B., Meekins, D., Melnitchouk, W., Metz, A., Meyer, C. A., Meziani, Z. -E., Mezrag, C., Michaels, R., Miller, G. A., Mineeva, T., Miramontes, A. S., Mirazita, M., Mizutani, K., Mkrtchyan, H., Mkrtchyan, A., Moffit, B., Mohanmurthy, P., Mokeev, V. I., Monaghan, P., Montaña, G., Montgomery, R., Moretti, A., Chàvez, J. M. Morgado, Mosel, U., Movsisyan, A., Musico, P., Nadeeshani, S. A, Nadolsky, P. M., Nakamura, S. X., Nazeer, J., Nefediev, A. V., Neupane, K., Nguyen, D., Niccolai, S., Niculescu, I., Niculescu, G., Nocera, E. R., Nycz, M., Olness, F. I., Ortega, P. G., Osipenko, M., Pace, E., Pandey, B, Pandey, P., Papandreou, Z., Papavassiliou, J., Pappalardo, L. L., Paredes-Torres, G., Paremuzyan, R., Park, S., Parsamyan, B., Paschke, K. D., Pasquini, B., Passemar, E., Pasyuk, E., Patel, T., Paudel, C., Paul, S. J., Peng, J-C., Pentchev, L., Perrino, R., Perry, R. J., Peters, K., Petratos, G. G., Phelps, W., Piasetzky, E., Pilloni, A., Pire, B., Pitonyak, D., Pitt, M. L., Polosa, A. D., Pospelov, M., Postuma, A. C., Poudel, J., Preet, L., Prelovsek, S., Price, J. W., Prokudin, A., Puckett, A. J. R., Pybus, J. R., Qin, S. -X., Qiu, J. -W., Radici, M., Rashidi, H., Rathnayake, A. D, Raue, B. A., Reed, T., Reimer, P. E., Reinhold, J., Richard, J. -M., Rinaldi, M., Ringer, F., Ripani, M., Ritman, J., West, J. Rittenhouse, Rivero-Acosta, A., Roberts, C. D., Rodas, A., Rodini, S., Rodríguez-Quintero, J., Rogers, T. C., Rojo, J., Rossi, P., Rossi, G. C., Salmè, G., Santiesteban, S. N., Santopinto, E., Sargsian, M., Sato, N., Schadmand, S., Schmidt, A., Schmidt, S. M, Schnell, G., Schumacher, R. A., Schweitzer, P., Scimemi, I., Scott, K. C, Seay, D. A, Segovia, J., Semenov-Tian-Shansky, K., Seryi, A., Sharda, A. S, Shepherd, M. R., Shirokov, E. V., Shrestha, S., Shrestha, U., Shvedunov, V. I., Signori, A., Slifer, K. J., Smith, W. A., Somov, A., Souder, P., Sparveris, N., Spizzo, F., Spreafico, M., Stepanyan, S., Stevens, J. R., Strakovsky, I. I., Strauch, S., Strikman, M., Su, S., Sumner, B. C. L., Sun, E., Suresh, M., Sutera, C., Swanson, E. S., Szczepaniak, A. P, Sznajder, P., Szumila-Vance, H., Szymanowski, L., Tadepalli, A. -S., Tadevosyan, V., Tamang, B., Tarasov, V. V., Thiel, A., Tong, X. -B., Tyson, R., Ungaro, M., Urciuoli, G. M., Usman, A., Valcarce, A., Vallarino, S., Vaquera-Araujo, C. A., Venturelli, L., Vera, F., Vladimirov, A., Vossen, A., Wagner, J., Wei, X., Weinstein, L. B., Weiss, C., Williams, R., Winney, D., Wojtsekhowski, B., Wood, M. H., Xiao, T., Xu, S. -S., Ye, Z., Yero, C., Yuan, C. -P., Yurov, M., Zachariou, N., Zhang, Z., Zhao, Z. W., Zhao, Y., Zheng, X., Zhou, X., Ziegler, V., Zihlmann, B., de Paula, W, and de Téramond, G. F.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

This document presents the initial scientific case for upgrading the Continuous Electron Beam Accelerator Facility (CEBAF) at Jefferson Lab (JLab) to 22 GeV. It is the result of a community effort, incorporating insights from a series of workshops conducted between March 2022 and April 2023. With a track record of over 25 years in delivering the world's most intense and precise multi-GeV electron beams, CEBAF's potential for a higher energy upgrade presents a unique opportunity for an innovative nuclear physics program, which seamlessly integrates a rich historical background with a promising future. The proposed physics program encompass a diverse range of investigations centered around the nonperturbative dynamics inherent in hadron structure and the exploration of strongly interacting systems. It builds upon the exceptional capabilities of CEBAF in high-luminosity operations, the availability of existing or planned Hall equipment, and recent advancements in accelerator technology. The proposed program cover various scientific topics, including Hadron Spectroscopy, Partonic Structure and Spin, Hadronization and Transverse Momentum, Spatial Structure, Mechanical Properties, Form Factors and Emergent Hadron Mass, Hadron-Quark Transition, and Nuclear Dynamics at Extreme Conditions, as well as QCD Confinement and Fundamental Symmetries. Each topic highlights the key measurements achievable at a 22 GeV CEBAF accelerator. Furthermore, this document outlines the significant physics outcomes and unique aspects of these programs that distinguish them from other existing or planned facilities. In summary, this document provides an exciting rationale for the energy upgrade of CEBAF to 22 GeV, outlining the transformative scientific potential that lies within reach, and the remarkable opportunities it offers for advancing our understanding of hadron physics and related fundamental phenomena., Comment: Updates to the list of authors; Preprint number changed from theory to experiment; Updates to sections 4 and 6, including additional figures

Published
2023

150. Weakly Lensed Gravitational Waves: Probing Cosmic Structures with Wave-Optics Features

Author

Savastano, Stefano, Tambalo, Giovanni, Villarrubia-Rojo, Hector, and Zumalacarregui, Miguel

Subjects
General Relativity and Quantum Cosmology, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Every signal propagating through the universe is at least weakly lensed by the intervening gravitational field. In some situations, wave-optics phenomena (diffraction, interference) can be observed as frequency-dependent modulations of the waveform of gravitational waves (GWs). We will denote these signatures as Wave-Optics Features (WOFs) and analyze them in detail. Our framework can efficiently and accurately compute WOF in the single-image regime, of which weak lensing is a limit. The phenomenology of WOF is rich and offers valuable information: the dense cusps of individual halos appear as peaks in Green's function for lensing. If resolved, these features probe the number, effective masses, spatial distribution and inner profiles of substructures. High signal-to-noise GW signals reveal WOFs well beyond the Einstein radius, leading to a fair probability of observation by upcoming detectors such as LISA. Potential applications of WOF include reconstruction of the lens' projected density, delensing standard sirens and inferring large-scale structure morphology and the halo mass function. Because WOF are sourced by light halos with negligible baryonic content, their detection (or lack thereof) holds promise to test dark matter scenarios., Comment: 26 pages, 12 figures

Published
2023

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