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105. Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into the complex genetic architecture

Author

Chia, Ruth, Sabir, Marya S., Bandres-Ciga, Sara, Saez-Atienzar, Sara, Reynolds, Regina H., Gustavsson, Emil, Walton, Ronald L., Ahmed, Sarah, Viollet, Coralie, Ding, Jinhui, Makarious, Mary B., Diez-Fairen, Monica, Portley, Makayla K., Shah, Zalak, Abramzon, Yevgeniya, Hernandez, Dena G., Blauwendraat, Cornelis, Stone, David J., Eicher, John, Parkkinen, Laura, Ansorge, Olaf, Clark, Lorraine, Honig, Lawrence S., Marder, Karen, Lemstra, Afina, George-Hyslop, Peter St, Londos, Elisabet, Morgan, Kevin, Lashley, Tammaryn, Warner, Thomas T., Jaunmuktane, Zane, Galasko, Douglas, Santana, Isabel, Tienari, Pentti J., Myllykangas, Liisa, Oinas, Minna, Cairns, Nigel J., Morris, John C., Halliday, Glenda M., Van Deerlin, Vivianna M., Trojanowski, John Q., Grassano, Maurizio, Calvo, Andrea, Mora, Gabriele, Canosa, Antonio, Floris, Gianluca, Bohannan, Ryan C., Brett, Francesca, Gan-Or, Ziv, Geiger, Joshua T., Moore, Anni, May, Patrick, Krüger, Rejko, Goldstein, David, Lopez, Grisel, Tayebi, Nahid, Sidransky, Ellen, Palma, Jose-Alberto, Kaufmann, Horacio, Shakkottai, Vikram, Perkins, Matthew, Newell, Kathy L., Gasser, Thomas, Schulte, Claudia, Landi, Francesco, Salvi, Erika, Cusi, Daniele, Masliah, Eliezer, Kim, Ronald C., Caraway, Chad A., Monuki, Ed, Brunetti, Maura, Dawson, Ted M., Rosenthal, Liana S., Albert, Marilyn S., Pletnikova, Olga, Troncoso, Juan C., Flanagan, Margaret E., Mao, Qinwen, Bigio, Eileen H., Rodríguez-Rodríguez, Eloy, Infante, Jon, Lage, Carmen, González-Aramburu, Isabel, Sanchez-Juan, Pascual, Ghetti, Bernardino, Keith, Julia, Black, Sandra E., Masellis, Mario, Rogaeva, Ekaterina, Duyckaerts, Charles, Brice, Alexis, Lesage, Suzanne, Xiromerisiou, Georgia, Barrett, Matthew J., Tilley, Bension S., Gentleman, Steve, Logroscino, Giancarlo, Serrano, Geidy E., Beach, Thomas G., McKeith, Ian G., Thomas, Alan J., Attems, Johannes, Morris, Christopher M., Palmer, Laura, Love, Seth, Troakes, Claire, Al-Sarraj, Safa, Hodges, Angela K., Aarsland, Dag, Klein, Gregory, Kaiser, Scott M., Woltjer, Randy, Pastor, Pau, Bekris, Lynn M., Leverenz, James, Besser, Lilah M., Kuzma, Amanda, Renton, Alan E., Goate, Alison, Bennett, David A., Scherzer, Clemens R., Morris, Huw R., Ferrari, Raffaele, Albani, Diego, Brown, Stuart Pickering, Faber, Kelley, Kukull, Walter, Morenas-Rodriguez, Estrella, Lleó, Alberto, Fortea, Juan, Alcolea, Daniel, Clarimon, Jordi, Nalls, Michael A., Ferrucci, Luigi, Resnick, Susan M., Tanaka, Toshiko, Foroud, Tatiana M., Graff-Radford, Neill R., Wszolek, Zbigniew K., Ferman, Tanis, Boeve, Bradley F., Hardy, John A., Topol, Eric, Torkamani, Ali, Singleton, Andrew B., Ryten, Mina, Dickson, Dennis, Chiò, Adriano, Ross, Owen A., Gibbs, J. Raphael, Dalgard, Clifton L., Traynor, Bryan J., and Scholz, Sonja W.

Subjects
whole-genome sequencing, GBA, Lewy body dementia, Biochemistry, biophysics & molecular biology [F05] [Life sciences], Biochimie, biophysique & biologie moléculaire [F05] [Sciences du vivant]
Abstract

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer’s and Parkinson’s disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition.Competing Interest StatementThomas G. Beach is a consultant for Prothena, Vivid Genomics and Avid Radiopharmaceuticals. He is a scientific advisory board member for Vivid Genomics. John A. Hardy, Huw R. Morris, Stuart Pickering-Brown, Andrew B. Singleton, and Bryan J. Traynor hold US, EU and Canadian patents on the clinical testing and therapeutic intervention for the hexanucleotide repeat expansion of C9orf72. Michael A. Nalls is supported by a consulting contract between Data Tecnica International and the National Institute on Aging, NIH, Bethesda, MD, USA; as a possible conflict of interest Dr. Nalls also consults for Neuron23 Inc., Lysosomal Therapeutics Inc., Illumina Inc., the Michael J. Fox Foundation and Vivid Genomics among others. Jose A. Palma is an editorial board member of Movement Disorders, Parkinsonism & Related Disorders, BMC Neurology, and Clinical Autonomic Research. Bradley F. Boeve, James Leverenz, and Sonja W. Scholz serve on the Scientific Advisory Council of the Lewy Body Dementia Association. Sonja W. Scholz is an editorial board member for the Journal of Parkinson's Disease. Bryan J. Traynor is an editorial board member for JAMA Neurology; Journal of Neurology, Neurosurgery, and Psychiatry; Brain; and Neurobiology of Aging. Zbigniew K. Wszolek serves as a principal investigator or co-principal investigator on Abbvie, Inc. (M15-562 and M15-563), Biogen, Inc. (228PD201) grant, and Biohaven Pharmaceuticals, Inc. (BHV4157-206 and BHV3241-301). Zbigniew K. Wszolek serves as the principal investigator of the Mayo Clinic American Parkinson Disease Association (APDA) Information and Referral Center, and as co-principal investigator of the Mayo Clinic APDA Center for Advanced Research. All other authors report no competing interests.

Published
2020

106. Correction to:A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity (Acta Neuropathologica, (2019), 138, 2, (237-250), 10.1007/s00401-019-02026-8)

Author

van der Lee, Sven J., Conway, Olivia J., Jansen, Iris, Carrasquillo, Minerva M., Kleineidam, Luca, van den Akker, Erik, Hernández, Isabel, van Eijk, Kristel R., Stringa, Najada, Chen, Jason A., Zettergren, Anna, Andlauer, Till F.M., Diez-Fairen, Monica, Simon-Sanchez, Javier, Lleó, Alberto, Zetterberg, Henrik, Nygaard, Marianne, Blauwendraat, Cornelis, Savage, Jeanne E., Mengel-From, Jonas, Moreno-Grau, Sonia, Wagner, Michael, Fortea, Juan, Keogh, Michael J., Blennow, Kaj, Skoog, Ingmar, Friese, Manuel A., Pletnikova, Olga, Zulaica, Miren, Lage, Carmen, de Rojas, Itziar, Riedel-Heller, Steffi, Illán-Gala, Ignacio, Wei, Wei, Jeune, Bernard, Orellana, Adelina, Then Bergh, Florian, Wang, Xue, Hulsman, Marc, Beker, Nina, Tesi, Niccolo, Morris, Christopher M., Indakoetxea, Begoña, Collij, Lyduine E., Scherer, Martin, Morenas-Rodríguez, Estrella, Ironside, James W., van Berckel, Bart N.M., Alcolea, Daniel, Wiendl, Heinz, Strickland, Samantha L., Pastor, Pau, Rodríguez Rodríguez, Eloy, Mead, S., Synofzik, M., van Swieten, J. C., Leber, I., Ferrari, R., Hernandez, D. G., Nalls, M. A., Rohrer, J. D., Ramasamy, A., Kwok, J. B.J., Dobson-Stone, C., Schofield, P. R., Halliday, G. M., Hodges, J. R., Piguet, O., Bartley, L., Thompson, E., Borroni, B., Padovani, A., Cruchaga, C., Cairns, N. J., Benussi, L., Binetti, G., Ghidoni, R., Forloni, G., Albani, D., Galimberti, D., Fenoglio, C., Serpente, M., Scarpini, E., Blesa, R., Landqvist Waldö, M., Nilsson, K., Nilsson, C., Mackenzie, I. R.A., Hsiung, G. Y.R., Mann, D. M.A., Grafman, J., Morris, C. M., Attems, J., Griffiths, T. D., McKeith, I. G., Thomas, A. J., Pietrini, P., Huey, E. D., Wassermann, E. M., Baborie, A., Jaros, E., Tierney, M. C., Razquin, C., Ortega-Cubero, S., Alonso, E., Perneczky, R., Diehl-Schmid, J., Alexopoulos, P., Kurz, A., Rainero, I., Rubino, E., Pinessi, L., Rogaeva, E., St George-Hyslop, P., Rossi, G., Tagliavini, F., Giaccone, G., Rowe, J. B., Schlachetzki, J. C.M., Uphill, J., Collinge, J., Danek, A., Van Deerlin, V. M., Grossman, M., Trojanowski, J. Q., van der Zee, J., Van Broeckhoven, C., Cappa, S. F., Hannequin, D., Golfier, V., Vercelletto, M., Brice, A., Nacmias, B., Sorbi, S., Bagnoli, S., Piaceri, I., Nielsen, J. E., Hjermind, L. E., Riemenschneider, M., Mayhaus, M., Ibach, B., Gasparoni, G., Pichler, S., Gu, W., Rossor, M. N., Fox, N. C., Warren, J. D., Spillantini, M. G., Morris, H. R., Rizzu, P., Snowden, J. S., Rollinson, S., Richardson, A., Gerhard, A., Bruni, A. C., Maletta, R., Frangipane, F., Cupidi, C., Bernardi, L., Anfossi, M., Gallo, M., Conidi, M. E., Smirne, N., Baker, M., Josephs, K. A., Parisi, J. E., Seeley, W. W., Miller, B. L., Karydas, A. M., Rosen, H., Dopper, E. G.P., Seelaar, H., Logroscino, G., Capozzo, R., Novelli, V., Puca, A. A., Franceschi, M., Postiglione, A., Milan, G., Sorrentino, P., Kristiansen, M., Chiang, H. H., Graff, C., Pasquier, F., Rollin, A., Deramecourt, V., Lebouvier, T., Kapogiannis, D., Ferrucci, L., Pickering-Brown, S., Singleton, A. B., Hardy, J., Momeni, P., Boeve, Bradley F., Petersen, Ronald C., Ferman, Tanis J., van Gerpen, Jay A., Reinders, Marcel J.T., Uitti, Ryan J., Tárraga, Lluís, Maier, Wolfgang, Dols-Icardo, Oriol, Kawalia, Amit, Dalmasso, Maria Carolina, Boada, Mercè, Zettl, Uwe K., van Schoor, Natasja M., Beekman, Marian, Allen, Mariet, Masliah, Eliezer, de Munain, Adolfo López, Pantelyat, Alexander, Wszolek, Zbigniew K., Ross, Owen A., Dickson, Dennis W., Graff-Radford, Neill R., Knopman, David, Rademakers, Rosa, Lemstra, Afina W., Pijnenburg, Yolande A.L., Scheltens, Philip, Gasser, Thomas, Chinnery, Patrick F., Hemmer, Bernhard, Huisman, Martijn A., Troncoso, Juan, Moreno, Fermin, Nohr, Ellen A., Sørensen, Thorkild I.A., Heutink, Peter, Sánchez-Juan, Pascual, Posthuma, Danielle, Coppola, G., Varpetian, A., Foroud, T. M., Levey, A. I., Kukull, W. A., Mendez, M. F., Ringman, J., Chui, H., Cotman, C., DeCarli, C., Geschwind, D. H., Clarimón, Jordi, Christensen, Kaare, Ertekin-Taner, Nilüfer, Scholz, Sonja W., Ramirez, Alfredo, Ruiz, Agustín, Slagboom, Eline, van der Flier, Wiesje M., and Holstege, Henne

Abstract

The IPDGC (The International Parkinson Disease Genomics Consortium) and EADB (Alzheimer Disease European DNA biobank) are listed correctly as an author to the article, however, they were incorrectly listed more than once.

Published
2020

107. Liderazgo transformacional y satisfacción laboral en docentes de Instituciones Educativas del distrito de Bambamarca, provincia de Bolívar 2020

Author

Echeverría Rodríguez, Eloy and Carranza Yuncor, Nelly Roxana

Subjects
Satisfacción en el trabajo, Liderazgo en la enseñanza, purl.org/pe-repo/ocde/ford#5.03.01 [http], Trabajadores - Formación profesional
Abstract

Este estudio tiene como objetivo determinar si hay una correspondencia importante y directa entre el liderazgo transformador y la satisfacción laboral de los maestros en dos instituciones educativas del distrito de Bambamarca, provincia de Bolívar 2020. Se aplicó el método de trabajo, según el propósito y según el diseño del estudio no fue probado ni observado, donde las muestras fueron convenientes y se conformaron de 31 profesores de ambas organizaciones. Como herramientas de recolección de datos se utilizan también el cuestionario de liderazgo multifactorial - MLQ y el cuestionario de satisfacción laboral (SL-SPC). Mediante la aplicación de estas herramientas se encontró un vínculo entre el liderazgo transformador y la satisfacción laboral en los profesores de dos instituciones educativas del distrito de Bambamarca, provincia de Bolívar 2020 (Rho s 0,907, ps 0,000, Alpha x 0,05). El nivel de cambios en el liderazgo es principalmente la categoría de características (59,4%, 19), la lista de liderazgo se marca como 12,5% (4) y la lista de liderazgo excelente es 28,1% ( 9). El nivel de satisfacción del principal trabajo de enseñanza no se alcanza (39,5%, 15), seguido de la satisfacción (23,7%, 9), el tipo medio y muy satisfecho es 10,5% (4 participantes). Se encontraron altos vínculos entre las dimensiones que influyen en el comportamiento cognitivo y la satisfacción en el trabajo (Rho s .904, p x 0.000, Alpha x 0.05). Se encontraron altos vínculos entre las dimensiones ideológicas debido a la satisfacción en el trabajo (Rho s 0.94, p x 0.000, Alpha x 0.05). Se encontró una alta asociación entre las dimensiones motivacionales de la inspiración y la satisfacción laboral (Rho s .907, p x 0.000, Alpha x 0.05). Finalmente, se encontró una alta asociación entre la dimensión de la estimulación intelectual y la satisfacción laboral (Rho s .907, p x 0.000, Alpha x 0.05). Trujillo Escuela de Posgrado Gestión y Calidad Educativa

Published
2020

108. Integración de diferentes dominios de seguridad: aplicación en sistemas militares

Author

Fernández Rodríguez, Eloy, Dranca, Lacramioara, and Fernández González, Javier

Abstract

Los dos sistemas de información para el mando y control principales en el Ejército de Tierra son, el Sistema de Información para el Mando y Control del Ejército de Tierra (SIMACET o SC2NET-D) y el Battlefield Management System (BMS). La intención del Ejército, es acreditar ambos sistemas, en un primer momento SIMACET a nivel RESERVADO y dejar BMS SIN CLASIFICAR. Esto supondría un problema para la transmisión de datos entre los dos sistemas, ya que actualmente intercambian información mediante dos pasarelas (COE e IDT), las cuales no cumplen los requisitos de seguridad necesarios.Por ello, este trabajo, se trata de una búsqueda de una solución segura que integre los dominios de seguridad de los dos sistemas de información mencionados. Para lograrlo, se ha seguido una metodología de búsqueda de información, entrevistas a personal experto y contactos con empresas del sector, tras todo ello, se realizó una comparativa de las posibles soluciones encontradas y se propuso una solución viable para el problema planteado. La mejor solución resultó ser la implementación de un diodo de datos, en concreto el PSTdiode de la empresa Autek. Además, se propone un método para implementar el diodo en una brigada del Ejército de Tierra acorde a las guías del Centro Criptológico Nacional y sin adquirir más material que los diodos. Finalmente se proponen dos posibles líneas de trabajo futuras: la resolución de un escenario SIMACET RESERVADO y BMS DIFUSIÓN LIMITADA (requeriría otro dispositivo distinto) y el desarrollo o adquisición de firewalls para el Ejército de Tierra.

Published
2020

109. De la expectación constitucional a la euforia supranacional: 1978-2018

Author

Gayán-Rodríguez, Eloy and Gayán-Rodríguez, Eloy

Abstract

[Resumen]: Un relato sobre los pioneros del Derecho internacional privado que culminaron con éxito su adaptación a los principios constitucionales del 78, tras recorrer un camino repleto de luces y sombras, de sobresaltos normativos, de interpretaciones críticas, para, finalmente, consolidar su disciplina. Luces y sombras que retornan con el actual proceso de internacionalidad constitucional, que devora las normas de Derecho internacional privado nacionales, el orden público en el que se sustentan. Un proceso dirigido y amparado por un Tribunal Europeo de Derechos Humanos que aventaja a las Constituciones nacionales, que ejerce su poder supranacional y convierte a los ordenamientos estatales, a sus principios y valores, en especies invasoras del Convenio Europeo de Derechos Humanos., [Abstract]: A story about the pioneers of Private International Law who successfully completed their adaptation to the constitutional principles of 78, after traveling a path full of lights and shadows, of normative shocks, of critical interpretations, to finally consolidate their discipline. Lights and shadows that return with the current process of constitutional internationality, which devours the norms of national Private International Law, the public order in which they are based. A process directed and protected by an European Court of Human Rights that is ahead of the national Constitutions, that exercises its supranational power and converts national law systems, their principles and values, into invaders species of the European Convention on Human Rights.

Published
2020

111. Distinctive Oculomotor Behaviors in Alzheimer's Disease and Frontotemporal Dementia

Author

Lage, Carmen, primary, López-García, Sara, additional, Bejanin, Alexandre, additional, Kazimierczak, Martha, additional, Aracil-Bolaños, Ignacio, additional, Calvo-Córdoba, Alberto, additional, Pozueta, Ana, additional, García-Martínez, María, additional, Fernández-Rodríguez, Andrea, additional, Bravo-González, María, additional, Jiménez-Bonilla, Julio, additional, Banzo, Ignacio, additional, Irure-Ventura, Juan, additional, Pegueroles, Jordi, additional, Illán-Gala, Ignacio, additional, Fortea, Juan, additional, Rodríguez-Rodríguez, Eloy, additional, Lleó-Bisa, Alberto, additional, García-Cena, Cecilia E., additional, and Sánchez-Juan, Pascual, additional

Published
2021
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112. Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

Author

Dewan, Ramita, primary, Chia, Ruth, additional, Ding, Jinhui, additional, Hickman, Richard A., additional, Stein, Thor D., additional, Abramzon, Yevgeniya, additional, Ahmed, Sarah, additional, Sabir, Marya S., additional, Portley, Makayla K., additional, Tucci, Arianna, additional, Ibáñez, Kristina, additional, Shankaracharya, F.N.U., additional, Keagle, Pamela, additional, Rossi, Giacomina, additional, Caroppo, Paola, additional, Tagliavini, Fabrizio, additional, Waldo, Maria L., additional, Johansson, Per M., additional, Nilsson, Christer F., additional, Rowe, James B., additional, Benussi, Luisa, additional, Binetti, Giuliano, additional, Ghidoni, Roberta, additional, Jabbari, Edwin, additional, Viollet, Coralie, additional, Glass, Jonathan D., additional, Singleton, Andrew B., additional, Silani, Vincenzo, additional, Ross, Owen A., additional, Ryten, Mina, additional, Torkamani, Ali, additional, Tanaka, Toshiko, additional, Ferrucci, Luigi, additional, Resnick, Susan M., additional, Pickering-Brown, Stuart, additional, Brady, Christopher B., additional, Kowal, Neil, additional, Hardy, John A., additional, Van Deerlin, Vivianna, additional, Vonsattel, Jean Paul, additional, Harms, Matthew B., additional, Morris, Huw R., additional, Ferrari, Raffaele, additional, Landers, John E., additional, Chiò, Adriano, additional, Gibbs, J. Raphael, additional, Dalgard, Clifton L., additional, Scholz, Sonja W., additional, Traynor, Bryan J., additional, Adeleye, Adelani, additional, Alba, Camille, additional, Bacikova, Dagmar, additional, Hupalo, Daniel N., additional, Martinez, Elisa McGrath, additional, Pollard, Harvey B., additional, Sukumar, Gauthaman, additional, Soltis, Anthony R., additional, Tuck, Meila, additional, Zhang, Xijun, additional, Wilkerson, Matthew D., additional, Smith, Bradley N., additional, Ticozzi, Nicola, additional, Fallini, Claudia, additional, Gkazi, Athina Soragia, additional, Topp, Simon D., additional, Kost, Jason, additional, Scotter, Emma L., additional, Kenna, Kevin P., additional, Miller, Jack W., additional, Tiloca, Cinzia, additional, Vance, Caroline, additional, Danielson, Eric W., additional, Troakes, Claire, additional, Colombrita, Claudia, additional, Al-Sarraj, Safa, additional, Lewis, Elizabeth A., additional, King, Andrew, additional, Calini, Daniela, additional, Pensato, Viviana, additional, Castellotti, Barbara, additional, de Belleroche, Jacqueline, additional, Baas, Frank, additional, ten Asbroek, Anneloor L.M.A., additional, Sapp, Peter C., additional, McKenna-Yasek, Diane, additional, McLaughlin, Russell L., additional, Polak, Meraida, additional, Asress, Seneshaw, additional, Esteban-Pérez, Jesús, additional, Muñoz-Blanco, José Luis, additional, Stevic, Zorica, additional, D’Alfonso, Sandra, additional, Mazzini, Letizia, additional, Comi, Giacomo P., additional, Del Bo, Roberto, additional, Ceroni, Mauro, additional, Gagliardi, Stella, additional, Querin, Giorgia, additional, Bertolin, Cinzia, additional, van Rheenen, Wouter, additional, Diekstra, Frank P., additional, Rademakers, Rosa, additional, van Blitterswijk, Marka, additional, Boylan, Kevin B., additional, Lauria, Giuseppe, additional, Duga, Stefano, additional, Corti, Stefania, additional, Cereda, Cristina, additional, Corrado, Lucia, additional, Sorarù, Gianni, additional, Williams, Kelly L., additional, Nicholson, Garth A., additional, Blair, Ian P., additional, Leblond-Manry, Claire, additional, Rouleau, Guy A., additional, Hardiman, Orla, additional, Morrison, Karen E., additional, Veldink, Jan H., additional, van den Berg, Leonard H., additional, Al-Chalabi, Ammar, additional, Pall, Hardev, additional, Shaw, Pamela J., additional, Turner, Martin R., additional, Talbot, Kevin, additional, Taroni, Franco, additional, García-Redondo, Alberto, additional, Wu, Zheyang, additional, Gellera, Cinzia, additional, Ratti, Antonia, additional, Brown, Robert H., additional, Shaw, Christopher E., additional, Ambrose, John C., additional, Arumugam, Prabhu, additional, Baple, Emma L., additional, Bleda, Marta, additional, Boardman-Pretty, Freya, additional, Boissiere, Jeanne M., additional, Boustred, Christopher R., additional, Brittain, H., additional, Caulfield, Mark J., additional, Chan, Georgia C., additional, Craig, Clare E.H., additional, Daugherty, Louise C., additional, de Burca, Anna, additional, Devereau, Andrew, additional, Elgar, Greg, additional, Foulger, Rebecca E., additional, Fowler, Tom, additional, Furió-Tarí, Pedro, additional, Hackett, Joanne M., additional, Halai, Dina, additional, Hamblin, Angela, additional, Henderson, Shirley, additional, Holman, James E., additional, Hubbard, Tim J.P., additional, Jackson, Rob, additional, Jones, Louise J., additional, Kasperaviciute, Dalia, additional, Kayikci, Melis, additional, Lahnstein, Lea, additional, Lawson, Kay, additional, Leigh, Sarah E.A., additional, Leong, Ivonne U.S., additional, Lopez, Javier F., additional, Maleady-Crowe, Fiona, additional, Mason, Joanne, additional, McDonagh, Ellen M., additional, Moutsianas, Loukas, additional, Mueller, Michael, additional, Murugaesu, Nirupa, additional, Need, Anna C., additional, Odhams, Chris A., additional, Patch, Christine, additional, Perez-Gil, Daniel, additional, Polychronopoulos, Dimitris, additional, Pullinger, John, additional, Rahim, Tahrima, additional, Rendon, Augusto, additional, Riesgo-Ferreiro, Pablo, additional, Rogers, Tim, additional, Savage, Kevin, additional, Sawant, Kushmita, additional, Scott, Richard H., additional, Siddiq, Afshan, additional, Sieghart, Alexander, additional, Smedley, Damian, additional, Smith, Katherine R., additional, Sosinsky, Alona, additional, Spooner, William, additional, Stevens, Helen E., additional, Stuckey, Alexander, additional, Sultana, Razvan, additional, Thomas, Ellen R.A., additional, Thompson, Simon R., additional, Tregidgo, Carolyn, additional, Walsh, Emma, additional, Watters, Sarah A., additional, Welland, Matthew J., additional, Williams, Eleanor, additional, Witkowska, Katarzyna, additional, Wood, Suzanne M., additional, Zarowiecki, Magdalena, additional, Arepalli, Sampath, additional, Auluck, Pavan, additional, Baloh, Robert H., additional, Bowser, Robert, additional, Brice, Alexis, additional, Broach, James, additional, Camu, William, additional, Cooper-Knock, John, additional, Corcia, Philippe, additional, Drepper, Carsten, additional, Drory, Vivian E., additional, Dunckley, Travis L., additional, Faghri, Faraz, additional, Farren, Jennifer, additional, Feldman, Eva, additional, Floeter, Mary Kay, additional, Fratta, Pietro, additional, Gerhard, Glenn, additional, Gibson, Summer B., additional, Goutman, Stephen A., additional, Heiman-Patterson, Terry D., additional, Hernandez, Dena G., additional, Hoover, Ben, additional, Jansson, Lilja, additional, Kamel, Freya, additional, Kirby, Janine, additional, Kowall, Neil W., additional, Laaksovirta, Hannu, additional, Landi, Francesco, additional, Le Ber, Isabelle, additional, Lumbroso, Serge, additional, MacGowan, Daniel JL., additional, Maragakis, Nicholas J., additional, Mora, Gabriele, additional, Mouzat, Kevin, additional, Myllykangas, Liisa, additional, Nalls, Mike A., additional, Orrell, Richard W., additional, Ostrow, Lyle W., additional, Pamphlett, Roger, additional, Pioro, Erik, additional, Pulst, Stefan M., additional, Ravits, John M., additional, Renton, Alan E., additional, Robberecht, Wim, additional, Robey, Ian, additional, Rogaeva, Ekaterina, additional, Rothstein, Jeffrey D., additional, Sendtner, Michael, additional, Sidle, Katie C., additional, Simmons, Zachary, additional, Stone, David J., additional, Tienari, Pentti J., additional, Trojanowski, John Q., additional, Troncoso, Juan C., additional, Valori, Miko, additional, Van Damme, Philip, additional, Van Den Bosch, Ludo, additional, Zinman, Lorne, additional, Albani, Diego, additional, Borroni, Barbara, additional, Padovani, Alessandro, additional, Bruni, Amalia, additional, Clarimon, Jordi, additional, Dols-Icardo, Oriol, additional, Illán-Gala, Ignacio, additional, Lleó, Alberto, additional, Danek, Adrian, additional, Galimberti, Daniela, additional, Scarpini, Elio, additional, Serpente, Maria, additional, Graff, Caroline, additional, Chiang, Huei-Hsin, additional, Khoshnood, Behzad, additional, Öijerstedt, Linn, additional, Morris, Christopher M., additional, Nacmias, Benedetta, additional, Sorbi, Sandro, additional, Nielsen, Jorgen E., additional, Hjermind, Lynne E., additional, Novelli, Valeria, additional, Puca, Annibale A., additional, Pastor, Pau, additional, Alvarez, Ignacio, additional, Diez-Fairen, Monica, additional, Aguilar, Miquel, additional, Perneczky, Robert, additional, Diehl-Schimd, Janine, additional, Rossi, Mina, additional, Ruiz, Agustin, additional, Boada, Mercè, additional, Hernández, Isabel, additional, Moreno-Grau, Sonia, additional, Schlachetzki, Johannes C., additional, Aarsland, Dag, additional, Albert, Marilyn S., additional, Attems, Johannes, additional, Barrett, Matthew J., additional, Beach, Thomas G., additional, Bekris, Lynn M., additional, Bennett, David A., additional, Besser, Lilah M., additional, Bigio, Eileen H., additional, Black, Sandra E., additional, Boeve, Bradley F., additional, Bohannan, Ryan C., additional, Brett, Francesca, additional, Brunetti, Maura, additional, Caraway, Chad A., additional, Palma, Jose-Alberto, additional, Calvo, Andrea, additional, Canosa, Antonio, additional, Dickson, Dennis, additional, Duyckaerts, Charles, additional, Faber, Kelley, additional, Ferman, Tanis, additional, Flanagan, Margaret E., additional, Floris, Gianluca, additional, Foroud, Tatiana M., additional, Fortea, Juan, additional, Gan-Or, Ziv, additional, Gentleman, Steve, additional, Ghetti, Bernardino, additional, Gibbs, Jesse Raphael, additional, Goate, Alison, additional, Goldstein, David, additional, González-Aramburu, Isabel, additional, Graff-Radford, Neill R., additional, Hodges, Angela K., additional, Hu, Heng-Chen, additional, Hupalo, Daniel, additional, Infante, Jon, additional, Iranzo, Alex, additional, Kaiser, Scott M., additional, Kaufmann, Horacio, additional, Keith, Julia, additional, Kim, Ronald C., additional, Klein, Gregory, additional, Krüger, Rejko, additional, Kukull, Walter, additional, Kuzma, Amanda, additional, Lage, Carmen, additional, Lesage, Suzanne, additional, Leverenz, James B., additional, Logroscino, Giancarlo, additional, Lopez, Grisel, additional, Love, Seth, additional, Mao, Qinwen, additional, Marti, Maria Jose, additional, Martinez-McGrath, Elisa, additional, Masellis, Mario, additional, Masliah, Eliezer, additional, May, Patrick, additional, McKeith, Ian, additional, Mesulam, Marek-Marsel, additional, Monuki, Edwin S., additional, Newell, Kathy L., additional, Norcliffe-Kaufmann, Lucy, additional, Palmer, Laura, additional, Perkins, Matthew, additional, Pletnikova, Olga, additional, Molina-Porcel, Laura, additional, Reynolds, Regina H., additional, Rodríguez-Rodríguez, Eloy, additional, Rohrer, Jonathan D., additional, Sanchez-Juan, Pascual, additional, Scherzer, Clemens R., additional, Serrano, Geidy E., additional, Shakkottai, Vikram, additional, Sidransky, Ellen, additional, Tayebi, Nahid, additional, Thomas, Alan J., additional, Tilley, Bension S., additional, Walton, Ronald L., additional, Woltjer, Randy, additional, Wszolek, Zbigniew K., additional, Xiromerisiou, Georgia, additional, Zecca, Chiara, additional, Phatnani, Hemali, additional, Kwan, Justin, additional, Sareen, Dhruv, additional, Broach, James R., additional, Arcila-Londono, Ximena, additional, Lee, Edward B., additional, Shneider, Neil A., additional, Fraenkel, Ernest, additional, Zaitlen, Noah, additional, Berry, James D., additional, Malaspina, Andrea, additional, Cox, Gregory A., additional, Thompson, Leslie M., additional, Finkbeiner, Steve, additional, Dardiotis, Efthimios, additional, Miller, Timothy M., additional, Chandran, Siddharthan, additional, Pal, Suvankar, additional, Hornstein, Eran, additional, MacGowan, Daniel J., additional, Heiman-Patterson, Terry, additional, Hammell, Molly G., additional, Patsopoulos, Nikolaos.A., additional, Butovsky, Oleg, additional, Dubnau, Joshua, additional, Nath, Avindra, additional, Harms, Matt, additional, Aronica, Eleonora, additional, Poss, Mary, additional, Phillips-Cremins, Jennifer, additional, Crary, John, additional, Atassi, Nazem, additional, Lange, Dale J., additional, Adams, Darius J., additional, Stefanis, Leonidas, additional, Gotkine, Marc, additional, Babu, Suma, additional, Raj, Towfique, additional, Paganoni, Sabrina, additional, Shalem, Ophir, additional, Smith, Colin, additional, Zhang, Bin, additional, Harris, Brent, additional, Broce, Iris, additional, Drory, Vivian, additional, Ravits, John, additional, McMillan, Corey, additional, Menon, Vilas, additional, Wu, Lani, additional, Altschuler, Steven, additional, Amar, Khaled, additional, Archibald, Neil, additional, Bandmann, Oliver, additional, Capps, Erica, additional, Church, Alistair, additional, Coebergh, Jan, additional, Costantini, Alyssa, additional, Critchley, Peter, additional, Ghosh, Boyd CP., additional, Hu, Michele T.M., additional, Kobylecki, Christopher, additional, Leigh, P. Nigel, additional, Mann, Carl, additional, Massey, Luke A., additional, Nath, Uma, additional, Pavese, Nicola, additional, Paviour, Dominic, additional, Sharma, Jagdish, additional, and Vaughan, Jenny, additional

Published
2021
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113. Identification and Mitigation of a Vibrational Telescope Systematic with Application to Spitzer

Author

Challener, Ryan C., primary, Harrington, Joseph, additional, Jenkins, James, additional, Kurtovic, Nicolás T., additional, Ramirez, Ricardo, additional, McIntyre, Kathleen J., additional, Himes, Michael D., additional, Rodríguez, Eloy, additional, Anglada-Escudé, Guillem, additional, Dreizler, Stefan, additional, Ofir, Aviv, additional, Peña Rojas, Pablo A., additional, Ribas, Ignasi, additional, Rojo, Patricio, additional, Kipping, David, additional, Butler, R. Paul, additional, Amado, Pedro J., additional, Rodríguez-López, Cristina, additional, Palle, Enric, additional, and Murgas, Felipe, additional

Published
2021
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114. Major Surgery Affects Memory in Individuals with Cerebral Amyloid-β Pathology

Author

Lage, Carmen, primary, González-Suárez, Andrea, additional, Alcalde-Hierro, María Puerto, additional, Sampedro-González, María Isabel, additional, Villanueva-Eguaras, María Ángeles, additional, Sánchez-Crespo, Manuel Rubén, additional, Widmann, Catherine, additional, Brosseron, Frederic, additional, Pozueta, Ana, additional, López-García, Sara, additional, García-Martínez, María, additional, Kazimierczak, Martha, additional, Bravo-González, María, additional, Fernández-Rodríguez, Andrea, additional, Drake-Pérez, Marta, additional, Irure-Ventura, Juan, additional, López-Hoyos, Marcos, additional, Rodríguez-Rodríguez, Eloy, additional, Heneka, Michael T., additional, and Sánchez-Juan, Pascual, additional

Published
2021
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116. Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia

Author

Ruiz, Agustín, Dols-Icardo, Oriol, Bullido, María J., Pastor, Pau, Rodríguez-Rodríguez, Eloy, López de Munain, Adolfo, de Pancorbo, Marian M., Pérez-Tur, Jordi, Álvarez, Victoria, Antonell, Anna, López-Arrieta, Jesús, Hernández, Isabel, Tárraga, Lluís, Boada, Mercè, Lleó, Alberto, Blesa, Rafael, Frank-García, Ana, Sastre, Isabel, Razquin, Cristina, Ortega-Cubero, Sara, Lorenzo, Elena, Sánchez-Juan, Pascual, Combarros, Onofre, Moreno, Fermín, Gorostidi, Ana, Elcoroaristizabal, Xabier, Baquero, Miquel, Coto, Eliecer, Sánchez-Valle, Raquel, and Clarimón, Jordi

Published
2014
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117. Evaluation of choroidal thickness in prodromal Alzheimer’s disease defined by amyloid PET

Author

López-de-Eguileta, Alicia, primary, Lage, Carmen, additional, López-García, Sara, additional, Pozueta, Ana, additional, García-Martínez, María, additional, Kazimierczak, Martha, additional, Bravo, María, additional, de Arcocha-Torres, María, additional, Banzo, Ignacio, additional, Jimenez-Bonilla, Julio, additional, Cerveró, Andrea, additional, Goikoetxea, Alexander, additional, Rodríguez-Rodríguez, Eloy, additional, Sánchez-Juan, Pascual, additional, and Casado, Alfonso, additional

Published
2020
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118. The Far Ultraviolet Variability of 29 Cygni

Author

Monier, Richard, primary, Carlos Suárez, Juan, additional, García Hernández, Antonio, additional, Moya, Andrés, additional, Pascual-Granado, Javier, additional, Rodríguez, Eloy, additional, Martín-Ruiz, Susana, additional, and Garrido, Rafael, additional

Published
2020
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120. A low-mass planet candidate orbiting Proxima Centauri at a distance of 1.5 AU

Author

Damasso, Mario, primary, Del Sordo, Fabio, additional, Anglada-Escudé, Guillem, additional, Giacobbe, Paolo, additional, Sozzetti, Alessandro, additional, Morbidelli, Alessandro, additional, Pojmanski, Grzegorz, additional, Barbato, Domenico, additional, Butler, R. Paul, additional, Jones, Hugh R. A., additional, Hambsch, Franz-Josef, additional, Jenkins, James S., additional, López-González, María José, additional, Morales, Nicolás, additional, Peña Rojas, Pablo A., additional, Rodríguez-López, Cristina, additional, Rodríguez, Eloy, additional, Amado, Pedro J., additional, Anglada, Guillem, additional, Feng, Fabo, additional, and Gómez, Jose F., additional

Published
2020
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122. Cognitive and Behavioral Profiles of Left and Right Semantic Dementia: Differential Diagnosis with Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease

Author

Pozueta, Ana, primary, Lage, Carmen, additional, García-Martínez, María, additional, Kazimierczak, Martha, additional, Bravo, María, additional, López-García, Sara, additional, Riancho, Javier, additional, González-Suarez, Andrea, additional, Vázquez-Higuera, José Luis, additional, de Arcocha-Torres, María, additional, Banzo, Ignacio, additional, Jiménez-Bonilla, Julio, additional, Berciano, José, additional, Rodríguez-Rodríguez, Eloy, additional, and Sánchez-Juan, Pascual, additional

Published
2019
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123. The MAPT H1 Haplotype Is a Risk Factor for Alzheimer’s Disease in APOE ε4 Non-carriers

Author

Sánchez-Juan, Pascual, primary, Moreno, Sonia, additional, de Rojas, Itziar, additional, Hernández, Isabel, additional, Valero, Sergi, additional, Alegret, Montse, additional, Montrreal, Laura, additional, García González, Pablo, additional, Lage, Carmen, additional, López-García, Sara, additional, Rodrííguez-Rodríguez, Eloy, additional, Orellana, Adelina, additional, Tárraga, Lluís, additional, Boada, Mercè, additional, and Ruiz, Agustín, additional

Published
2019
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128. Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Author

van der Lee, Sven J, Conway, Olivia J, Zettergren, Anna, Christensen, Kaare, Ertekin-Taner, Nilüfer, Scholz, Sonja W, Ramirez, Alfredo, Ruiz, Agustín, Slagboom, Eline, van der Flier, Wiesje M, Holstege, Henne, Mead, S., Synofzik, M., Andlauer, Till F M, van Swieten, J. C., Leber, I., Ferrari, R., Hernandez, D. G., Nalls, M. A., Rohrer, J. D., Ramasamy, A., Kwok, J. B. J., Dobson-Stone, C., Schofield, P. R., Diez-Fairen, Monica, Halliday, G. M., Hodges, J. R., Piguet, O., Bartley, L., Thompson, E., Borroni, B., Padovani, A., Cruchaga, C., Cairns, N. J., Benussi, L., Simon-Sanchez, Javier, Binetti, G., Ghidoni, R., Forloni, G., Albani, D., Galimberti, D., Fenoglio, C., Serpente, M., Scarpini, E., Blesa, R., Landqvist Waldö, M., Lleó, Alberto, Nilsson, K., Nilsson, C., Mackenzie, I. R. A., Hsiung, G-Y R, Mann, D. M. A., Grafman, J., Morris, C. M., Attems, J., Griffiths, T. D., McKeith, I. G., Zetterberg, Henrik, Thomas, A. J., Pietrini, P., Huey, E. D., Wassermann, E. M., Baborie, A., Jaros, E., Tierney, M. C., Razquin, C., Ortega-Cubero, S., Alonso, E., Nygaard, Marianne, Perneczky, R., Diehl-Schmid, J., Alexopoulos, P., Kurz, A., Rainero, I., Rubino, E., Pinessi, L., Rogaeva, E., St George-Hyslop, P., Rossi, G., Blauwendraat, Cornelis, Tagliavini, F., Giaccone, G., Rowe, J. B., Schlachetzki, J. C. M., Uphill, J., Collinge, J., Danek, A., Van Deerlin, V. M., Grossman, M., Trojanowski, J. Q., Savage, Jeanne E, van der Zee, J., Van Broeckhoven, C., Cappa, S. F., Hannequin, D., Golfier, V., Vercelletto, M., Brice, A., Nacmias, B., Sorbi, S., Bagnoli, S., Mengel-From, Jonas, Piaceri, I., Nielsen, J. E., Hjermind, L. E., Riemenschneider, M., Mayhaus, M., Ibach, B., Gasparoni, G., Pichler, S., Gu, W., Rossor, M. N., Jansen, Iris, Moreno-Grau, Sonia, Fox, N. C., Warren, J. D., Spillantini, M. G., Morris, H. R., Rizzu, P., Snowden, J. S., Rollinson, S., Richardson, A., Gerhard, A., Bruni, A. C., Wagner, Michael, Maletta, R., Frangipane, F., Cupidi, C., Bernardi, L., Anfossi, M., Gallo, M., Conidi, M. E., Smirne, N., Baker, M., Josephs, K. A., Fortea, Juan, Parisi, J. E., Seeley, W. W., Miller, B. L., Karydas, A. M., Rosen, H., Dopper, E. G. P., Seelaar, H., Logroscino, G., Capozzo, R., Novelli, V., Keogh, Michael J, Puca, A. A., Franceschi, M., Postiglione, A., Milan, G., Sorrentino, P., Kristiansen, M., Chiang, H-H, Graff, C., Pasquier, F., Rollin, A., Blennow, Kaj, Deramecourt, V., Lebouvier, T., Kapogiannis, D., Ferrucci, L., Pickering-Brown, S., Singleton, A. B., Hardy, J., Momeni, P., Coppola, G., Skoog, Ingmar, Varpetian, A., Foroud, T. M., Levey, A. I., Kukull, W. A., Mendez, M. F., Ringman, J., Chui, H., Cotman, C., DeCarli, C., Friese, Manuel A, Geschwind, D. H., Pletnikova, Olga, Zulaica, Miren, Lage, Carmen, Carrasquillo, Minerva M, de Rojas, Itziar, Riedel-Heller, Steffi, Illán-Gala, Ignacio, Wei, Wei, Jeune, Bernard, Orellana, Adelina, Then Bergh, Florian, Wang, Xue, Hulsman, Marc, Beker, Nina, Kleineidam, Luca, Tesi, Niccolo, Morris, Christopher M, Indakoetxea, Begoña, Collij, Lyduine E, Scherer, Martin, Morenas-Rodríguez, Estrella, Ironside, James W, van Berckel, Bart N M, Alcolea, Daniel, Wiendl, Heinz, van den Akker, Erik, Strickland, Samantha L, Pastor, Pau, Rodríguez Rodríguez, Eloy, DESGESCO, EADB, IFGC, IPDGC, RiMod-FTD, Bank, Netherlands Brain, Boeve, Bradley F, Hernández, Isabel, Petersen, Ronald C, Ferman, Tanis J, van Gerpen, Jay A, Reinders, Marcel J T, Uitti, Ryan J, Tárraga, Lluís, Maier, Wolfgang, Dols-Icardo, Oriol, Kawalia, Amit, Dalmasso, Maria Carolina, van Eijk, Kristel R, Boada, Mercè, Zettl, Uwe K, van Schoor, Natasja M, Beekman, Marian, Allen, Mariet, Masliah, Eliezer, de Munain, Adolfo López, Pantelyat, Alexander, Wszolek, Zbigniew K, Ross, Owen A, Stringa, Najada, Dickson, Dennis W, Graff-Radford, Neill R, Knopman, David, Rademakers, Rosa, Lemstra, Afina W, Pijnenburg, Yolande A L, Scheltens, Philip, Gasser, Thomas, Chinnery, Patrick F, Hemmer, Bernhard, Chen, Jason A, Huisman, Martijn A, Troncoso, Juan, Moreno, Fermin, Nohr, Ellen A, Sørensen, Thorkild I A, Heutink, Peter, Sánchez-Juan, Pascual, Posthuma, Danielle, GIFT, and Clarimón, Jordi

Subjects
0301 basic medicine, Dementia with Lewy bodies, Disease, Bioinformatics, Neurodegenerative disease, 0302 clinical medicine, Missense mutation, media_common, 2. Zero hunger, Longevity, Brain, Parkinson Disease, Phospholipase C Gamma 2, Biobank, 3. Good health, ddc, Frontotemporal Dementia, Microglia, Alzheimer's disease, Alzheimer’s disease, Amyotrophic lateral sclerosis, Frontotemporal dementia, Multiple sclerosis, PLCG2, Parkinson’s disease, Progressive supranuclear palsy, Lewy Body Disease, Risk, Multiple Sclerosis, media_common.quotation_subject, education, Neuroimaging, Genomics, Pathology and Forensic Medicine, 03 medical and health sciences, Cellular and Molecular Neuroscience, SDG 3 - Good Health and Well-being, Alzheimer Disease, medicine, Humans, Genetic Predisposition to Disease, ddc:610, Alleles, Phospholipase C gamma, business.industry, Amyotrophic Lateral Sclerosis, Correction, medicine.disease, 030104 developmental biology, Mutation, Dementia, Neurology (clinical), business, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target. The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target.

Published
2019

129. The epistasis project: A multi-cohort study of the effects of BDNF, DBH, and SORT1 epistasis on Alzheimer's disease risk

Author

Alzheimer's Research UK, Alzheimer's BRACE, Medical Research Council (UK), NIHR Biomedical Research Centre (UK), Instituto de Investigación Marqués de Valdecilla, Instituto de Salud Carlos III, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Erasmus University Rotterdam, Netherlands Organisation for Health Research and Development, Ministerio de Educación, Cultura y Deporte (España), Ministerio de Sanidad (España), European Commission, Netherlands Organization for Scientific Research, Belbin, Olivia, Morgan, Kevin, Medway, Chris, Warden, Donald, Cortina-Borja,Mario, Van Dujin, Cornelia, M, Adams, Heiab H.H., Frank-García, Ana, Brookes, Keeley, Sánchez-Juan, Pascual, Álvarez, Victoria, Heun, Reinhard, Kölsch, Heike, Coto, Eliecer, Kehoe, Patrick G., Rodríguez-Rodríguez, Eloy, Bullido, María Jesús, Ikram, M. Arfan, Smith A. David, Lehmann, Donald J., Alzheimer's Research UK, Alzheimer's BRACE, Medical Research Council (UK), NIHR Biomedical Research Centre (UK), Instituto de Investigación Marqués de Valdecilla, Instituto de Salud Carlos III, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Erasmus University Rotterdam, Netherlands Organisation for Health Research and Development, Ministerio de Educación, Cultura y Deporte (España), Ministerio de Sanidad (España), European Commission, Netherlands Organization for Scientific Research, Belbin, Olivia, Morgan, Kevin, Medway, Chris, Warden, Donald, Cortina-Borja,Mario, Van Dujin, Cornelia, M, Adams, Heiab H.H., Frank-García, Ana, Brookes, Keeley, Sánchez-Juan, Pascual, Álvarez, Victoria, Heun, Reinhard, Kölsch, Heike, Coto, Eliecer, Kehoe, Patrick G., Rodríguez-Rodríguez, Eloy, Bullido, María Jesús, Ikram, M. Arfan, Smith A. David, and Lehmann, Donald J.

Abstract

Pre-synaptic secretion of brain-derived neurotrophic factor (BDNF) from noradrenergic neurons may protect the Alzheimer's disease (AD) brain from amyloid pathology. While the BDNF polymorphism (rs6265) is associated with faster cognitive decline and increased hippocampal atrophy, a replicable genetic association of BDNF with AD risk has yet to be demonstrated. This could be due to masking by underlying epistatic interactions between BDNF and other loci that encode proteins involved in moderating BDNF secretion (DBH and Sortilin).We performed a multi-cohort case-control association study of the BDNF,DBH, and SORT1 loci comprising 5,682 controls and 2,454ADpatients from Northern Europe(87% of samples) and Spain (13%). The BDNF locus was associated with increased AD risk (odds ratios; OR= 1.1-1.2, p = 0.005-0.3), an effect size that was consistent in the Northern European (OR = 1.1-1.2, p = 0.002-0.8) but not the smaller Spanish (OR = 0.8-1.6, p = 0.4-1.0) subset. A synergistic interaction between BDNF and sex (synergy factor; SF = 1.3-1.5 p = 0.002-0.02) translated to a greater risk of AD associated with BDNF in women (OR = 1.2-1.3, p = 0.007-0.00008) than men (OR = 0.9-1.0, p = 0.3-0.6). While the DBH polymorphism (rs1611115) was also associated with increased AD risk (OR = 1.1, p = 0.04) the synergistic interaction (SF = 2.2, p = 0.007) betweenBDNF(rs6265) andDBH(rs1611115) contributed greater AD risk than either gene alone, an effect that was greater in women (SF = 2.4, p = 0.04) than men (SF = 2.0, p = 0.2). These data support a complex genetic interaction at loci encoding proteins implicated in the DBH-BDNF inflammatory pathway that modifies AD risk, particularly in women.

Published
2019

131. Anucinante

Author

Castañeda Álvarez, Aida Nieves, González González, Alba, Álvarez Rodríguez, Eloy Antonio, and Ortega Rivas, Antonio

Subjects
Aprendizaje cooperativo, Tecnología de la información y la comunicación, Educación primaria
Published
2018

132. A Brief Drawing Task for the Differential Diagnosis of Semantic Dementia

Author

Pozueta, Ana, primary, Lage, Carmen, additional, Martínez, María García, additional, Kazimierczak, Martha, additional, Bravo, María, additional, López-García, Sara, additional, Riancho, Javier, additional, González-Suarez, Andrea, additional, Vázquez-Higuera, José Luis, additional, de Arcocha-Torres, María, additional, Banzo, Ignacio, additional, Bonilla, Julio Jimenez, additional, Berciano, José, additional, Rodríguez-Rodríguez, Eloy, additional, and Sánchez-Juan, Pascual, additional

Published
2019
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134. Proxima Centauri b is not a transiting exoplanet

Author

Jenkins, James S, primary, Harrington, Joseph, primary, Challener, Ryan C, primary, Kurtovic, Nicolás T, primary, Ramirez, Ricardo, primary, Peña, Jose, primary, McIntyre, Kathleen J, primary, Himes, Michael D, primary, Rodríguez, Eloy, primary, Anglada-Escudé, Guillem, primary, Dreizler, Stefan, primary, Ofir, Aviv, primary, Peña Rojas, Pablo A, primary, Ribas, Ignasi, primary, Rojo, Patricio, primary, Kipping, David, primary, Butler, R Paul, primary, Amado, Pedro J, primary, Rodríguez-López, Cristina, primary, Kempton, Eliza M-R, primary, Palle, Enric, primary, and Murgas, Felipe, primary

Published
2019
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135. Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk

Author

Berciano José, Valdivieso Fernando, Frank-García Ana, Dobato José L, Calero Miguel, Pozueta Ana, Rodríguez-Rodríguez Eloy, Sánchez-Juan Pascual, Mateo Ignacio, Vázquez-Higuera José L, Bullido Maria J, and Combarros Onofre

Subjects
Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Background Tau abnormal hyperphosphorylation and the formation of neurofibrillary tangles in AD brain is the result of upregulation of tau kinases and downregulation of tau phosphatases. Methods In a group of 729 Spanish late-onset Alzheimer's disease (AD) patients and 670 healthy controls, we examined variations into a set of candidate genes (PPP2CA, PPP2R2A, ANP32A, LCMT1, PPME1 and PIN1) in the tau protein phosphatase-2A (PP2A) pathway, to address hypotheses of genetic variation that might influence AD risk. Results There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by age, gender or APOE ε4 allele. Conclusion Our negative findings in the Spanish population argue against the hypothesis that genetic variation in the tau protein phosphatase-2A (PP2A) pathway is causally related to AD risk

Published
2011
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136. Detection of early Alzheimer's disease in MCI patients by the combination of MMSE and an episodic memory test

Author

Berciano José, González-Perez Soraya, Sánchez-Juan Pascual, Mateo Ignacio, Vazquez-Higuera José, Rodríguez-Rodríguez Eloy, Pozueta Ana, and Combarros Onofre

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Mild cognitive impairment (MCI) is a heterogeneous clinical entity that comprises the prodromal phase of Alzheimer's disease (Pr-AD). New biomarkers are useful in detecting Pr-AD, but they are not universally available. We aimed to investigate baseline clinical and neuropsychological variables that might predict progression from MCI to AD dementia. Methods All patients underwent a complete clinical and neuropsychological evaluation at baseline and every 6 months during a two-year follow-up period, with 54 out of 109 MCI patients progressing to dementia (50 of them progressed to AD dementia), and 55 remaining as stable MCI (S-MCI). Results A combination of MMSE and California Verbal Learning Test Long Delayed Total Recall (CVLT-LDTR) constituted the best predictive model: subjects scoring above 26/30 on MMSE and 4/16 on CVLT-LDTR had a negative predictive value of 93.93% at 2 years, whereas those subjects scoring below both of these cut-off scores had a positive predictive value of 80.95%. Conclusions Pr-AD might be distinguished from S-MCI at baseline using the combination of MMSE and CVLT-LDTR. These two neuropsychological predictors are relatively brief and may be readily completed in non-specialist clinical settings.

Published
2011
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137. Caspase-1 genetic variation is not associated with Alzheimer's disease risk

Author

Berciano José, Valdivieso Fernando, Frank Ana, Martínez-García Ana, Pozueta Ana, Mateo Ignacio, Sánchez-Juan Pascual, Rodríguez-Rodríguez Eloy, Vázquez-Higuera José, Bullido María J, and Combarros Onofre

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Interleukin (IL)-1β is a potent proinflammatory cytokine markedly overexpressed in the brains of patients with Alzheimer's disease (AD), and also involved in development of atherosclerosis and coronary artery disease. Caspase-1 (CASP1), formerly called IL-1β converting enzyme (ICE), mediates the cleavage of the inactive precursor of IL-1β into the biologically active form. CASP1 genetic variation (G+7/in6A, rs501192) has been associated with susceptibility to myocardial infarction and cardiovascular death risk. We examined the contribution of this gene to the susceptibility for AD. Methods We examined genetic variations of CASP1 by genotyping haplotype tagging SNPs (htSNPs) (rs501192, rs556205 and rs530537) in a group of 628 Spanish AD cases and 722 controls. Results There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by age, gender or APOE ε4 allele. Conclusion Our negative findings in the Spanish population argue against the hypothesis that CASP1 genetic variations are causally related to AD risk.

Published
2010
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138. Genetic variation in APOE cluster region and Alzheimer's disease risk

Author

Cervantes, Sebastián, Samaranch, Lluís, Vidal-Taboada, José Manuel, Lamet, Isabel, Bullido, María Jesús, Frank-García, Ana, Coria, Francisco, Lleó, Albert, Clarimón, Jordi, Lorenzo, Elena, Alonso, Elena, Sánchez-Juan, Pascual, Rodríguez-Rodríguez, Eloy, Combarros, Onofre, Rosich, Marcel, Vilella, Elisabet, and Pastor, Pau

Published
2011
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139. IGF-I gene variability is associated with an increased risk for AD

Author

Vargas, Teo, Martinez-Garcia, Ana, Antequera, Desiree, Vilella, Elisabet, Clarimon, Jordi, Mateo, Ignacio, Sanchez-Juan, Pascual, Rodriguez-Rodriguez, Eloy, Frank, Ana, Rosich-Estrago, Marcel, Lleo, Alberto, Molina-Porcel, Laura, Blesa, Rafael, Gomez-Isla, Teresa, Combarros, Onofre, Bermejo-Pareja, Felix, Valdivieso, Fernando, Bullido, Maria Jesus, and Carro, Eva

Published
2011
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141. DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort

Author

Berciano José, Valdivieso Fernando, Sastre Isabel, Frank Ana, Pozueta Ana, Mateo Ignacio, Rodríguez-Rodríguez Eloy, Sánchez-Juan Pascual, Vázquez-Higuera José, Bullido María J, and Combarros Onofre

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background As dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) has been implicated in the abnormal hyperphosphorylation of tau in Alzheimer's disease (AD) brain, and the development of neurofibrillary tangles, we examined the contribution of this gene to the susceptibility for AD. Methods We examined genetic variations of DYRK1A by genotyping haplotype tagging SNPs (htSNPs) (rs11701483, rs2835740, rs1137600, rs2835761, rs2835762, rs2154545 and rs8132976) in a group of 634 Spanish AD cases and 733 controls. Results There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by APOE ε4 allele. Conclusion Our negative findings in the Spanish population argue against the hypothesis that DYRK1A genetic variations are causally related to AD risk. Still, additional studies using different sets of patients and control subjects deserve further attention, since supporting evidence for association between DYRK1A gene and AD risk in the Japanese population exists.

Published
2009
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142. No association of CDK5 genetic variants with Alzheimer's disease risk

Author

Combarros Onofre, Berciano José, Infante Jon, Rodríguez-Rodríguez Eloy, Sánchez-Juan Pascual, Mateo Ignacio, and Vázquez-Higuera José

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background As cyclin-dependent kinase 5 (CDK5) has been implicated in the abnormal hyperphosphorylation of tau in Alzheimer's disease (AD) brain, and the development of neurofibrillary tangles, we examined the contribution of this gene to the susceptibility for AD. Methods We examined genetic variations of CDK5 by genotyping haplotype tagging SNPs (htSNPs) (rs9278, rs2069459, rs891507, rs2069454, rs1549759 and rs2069442) in a group of 408 Spanish AD cases and 444 controls. Results There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by APOE ε4 allele. Conclusion Our negative findings in the Spanish population argue against the hypothesis that CDK5 genetic variations are causally related to AD risk. Still, additional studies using different sets of patients and control subjects deserve further attention, since supporting evidence for association between CDK5 gene and AD risk in the Dutch population exists.

Published
2009
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144. Diseño de una instalación solar térmica para calentamiento de agua caliente sanitaria en una residencia de mayores

Author

García Rodríguez, Eloy José, Guerra Macho, José Julio, and Universidad de Sevilla. Departamento de Ingeniería Energética

Subjects
Residencia Claret de Sevilla, Instalaciones solares
Abstract

El siguiente trabajo trata el estudio y dimensionado de una instalación solar térmica de baja temperatura para calentamiento de ACS. El diseño de dicha instalación se ha realizado para la residencia de mayores Claret de Sevilla. Este documento consta de cinco documentos básicos: Memoria descriptiva, Memoria de cálculo, Pliegos de condiciones técnicas y administrativas, Presupuesto y Planos. La función de cada documento básico queda definida por su propio nombre, no obstante, se dedica un breve apartado al inicio de cada documento para especificar su cometido. En dicho trabajo se ha utilizado la herramienta CHEQ4, herramienta desarrollada por el IDAE y la ASIT para la validación del cumplimiento de la contribución solar mínima. Con dicha herramienta se han realizado una serie de curvas donde se puede observar las prestaciones de la instalación cuando se varía el volumen de acumulación, la superficie de captación, o ambos. El sistema completo y cada uno de sus componentes han sido dimensionados respetando la normativa vigente, cumpliendo en todo momento con el CTE. Universidad de Sevilla. Grado en Ingeniería de la Energía

Published
2017

145. Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis

Author

Armangue, Thaís, primary, Spatola, Marianna, additional, Vlagea, Alexandru, additional, Mattozzi, Simone, additional, Cárceles-Cordon, Marc, additional, Martinez-Heras, Eloy, additional, Llufriu, Sara, additional, Muchart, Jordi, additional, Erro, María Elena, additional, Abraira, Laura, additional, Moris, German, additional, Monros-Giménez, Luis, additional, Corral-Corral, Íñigo, additional, Montejo, Carmen, additional, Toledo, Manuel, additional, Bataller, Luis, additional, Secondi, Gabriela, additional, Ariño, Helena, additional, Martínez-Hernández, Eugenia, additional, Juan, Manel, additional, Marcos, Maria Angeles, additional, Alsina, Laia, additional, Saiz, Albert, additional, Rosenfeld, Myrna R, additional, Graus, Francesc, additional, Dalmau, Josep, additional, Aguilera-Albesa, Sergio, additional, Amado-Puentes, Alfonso, additional, Arjona-Padillo, Antonio, additional, Arrabal, Luisa, additional, Arratibel, Izascun, additional, Aznar-Laín, Gemma, additional, Bellas-Lamas, Paula, additional, Bermejo, Teresa, additional, Boyero-Durán, Sabas, additional, Camacho, Ana, additional, Campo, Andrea, additional, Campos, Dulce, additional, Cantarín-Extremera, Verónica, additional, Carnero, Cristóbal, additional, Conejo-Moreno, David, additional, Dapena, Marta, additional, Dacruz-Álvarez, David, additional, Delgadillo-Chilavert, Verónica, additional, Deyà, Angela, additional, Estela-Herrero, Jordi, additional, Felipe, Anna, additional, Fernández-Cooke, Elisa, additional, Fernández-Ramos, Joaquín, additional, Fortuny, Claudia, additional, García-Monco, Juan C, additional, Gili, Teresa, additional, González-Álvarez, Verónica, additional, Guerri, Robert, additional, Guillén, Sara, additional, Hedrera-Fernández, Antonio, additional, López, María, additional, López-Laso, Eduardo, additional, Lorenzo-Ruiz, María, additional, Madruga, Marcos, additional, Málaga-Diéguez, Ignacio, additional, Martí-Carrera, Itxaso, additional, Martínez-Lacasa, Xavier, additional, Martín-Viota, Lucía, additional, Martín Gil, Leticia, additional, Martínez-González, María-Jesús, additional, Moreira, Antia, additional, Miranda-Herrero, María C, additional, Monge, Lorena, additional, Muñoz-Cabello, Beatriz, additional, Navarro-Morón, Juan, additional, Neth, Olaf, additional, Noguera-Julian, Antoni, additional, Nuñez-Enamorado, Noemí, additional, Pomar, Virginia, additional, Portillo-Cuenca, Juan C, additional, Poyato, María, additional, Prieto, Luis, additional, Querol, Luis, additional, Rodríguez-Rodríguez, Eloy, additional, Sarria-Estrada, Silvana, additional, Sierra, Concepción, additional, Soler-Palacín, Pere, additional, Soto-Insuga, Víctor, additional, Toledo-Bravo, Laura, additional, Tomás, Miguel, additional, Torres-Torres, Carmen, additional, Turón, Eulàlia, additional, and Zabalza, Ana, additional

Published
2018
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146. A Nonsynonymous Mutation in PLCG2 Reduces the Risk of Alzheimer's Disease, Dementia with Lewy-Bodies and Frontotemporal Dementia, and Increases the Likelihood of Longevity

Author

van der Lee, Sven J., primary, Conway, Olivia J., additional, Jansen, Iris, additional, Carrasquillo, Minerva M., additional, Kleineidam, Luca, additional, Akker, Erik van den, additional, Hernández, Isabel, additional, Van Eijk, Kristel R., additional, Stringa, Najada, additional, Chen, Jason A., additional, Zettergren, Anna, additional, Andlauer, Till F. M., additional, Diez-Fairen, Monica, additional, Simon-Sanchez, Javier, additional, Lleó, Alberto, additional, Zetterberg, Henrik, additional, Nygaard, Marianne, additional, Blauwendraat, Cornelis, additional, Savage, Jeanne E., additional, Mengel-From, Jonas, additional, Moreno-Grau, Sonia, additional, Wagner, Michael, additional, Fortea, Juan, additional, Keogh, Michael J., additional, Blennow, Kaj, additional, Skoog, Ingmar, additional, Friese, Manuel A., additional, Pletnikova, Olga, additional, Zulaica, Miren, additional, Lage, Carmen, additional, de Rojas, Itziar, additional, Riedel-Heller, Steffi, additional, Illán-Gala, Ignacio, additional, Wei, Wei, additional, Jeune, Bernard, additional, Orellana, Adela, additional, Bergh, Florian Then, additional, Wang, Xue, additional, Hulsman, Marc, additional, Beker, Nina, additional, Tesí, Niccolo, additional, Morris, Christopher, additional, Indakoetxea, Begoña, additional, Collij, Lyduine E., additional, Scherer, Martin, additional, Morenas-Rodríguez, Estrella, additional, Ironside, James W., additional, Berckel, Bart. N.M. van, additional, Alcolea, Daniel, additional, Wiendl, Heinz, additional, Strickland, Samantha L., additional, Pastor, Pau, additional, Rodríguez, Eloy Rodríguez, additional, Consortium, DESGESCO Dementia Genetics Spanish, additional, Biobank, Alzheimer Disease European DNA, additional, Consortium, IFGC International FTD-Genomics, additional, Consortium, IPDGC The International Parkinson D, additional, Dementia, RiMod-FTD Rsk and Modifying factors, additional, Boeve, Bradley F., additional, Petersen, Ronald C., additional, Ferman, Tanis J., additional, Gerpen, Jay A. van, additional, Reinders, Marcel J. T., additional, Uitti, Ryan J., additional, Tarraga, Lluis, additional, Maier, Wolfgang, additional, Dols-Icardo, Oriol, additional, Kawalia, Amit, additional, Dalmasso, Maria Carolina, additional, Boada, Mercè, additional, Zettl, Uwe K., additional, van Schoor, Natasja M., additional, Beekman, Marian, additional, Allen, Mariet, additional, Masliah, Eliezer, additional, Munain, Adolfo López de, additional, Pantelyat, Alexander, additional, Wszolek, Zbigniew K., additional, Ross, Owen A., additional, Dickson, Dennis W., additional, Graff-Radford, Neill R., additional, Knopman, David, additional, Rademakers, Rosa, additional, Lemstra, Afina W., additional, Pijnenburg, Yolande A. L., additional, Scheltens, Philip, additional, Gasser, Thomas, additional, Chinnery, Patrick F., additional, Hemmer, Bernhard, additional, Huisman, Martijn A., additional, Troncoso, Juan, additional, Moreno, Fermin, additional, Nohr, Ellen A., additional, Sørensen, Thorkild I. A., additional, Heutink, Peter, additional, Sánchez-Juan, Pascual, additional, Posthuma, Danielle, additional, Coppola, Giovanni, additional, Clarimón, Jordi, additional, Christensen, Kaare, additional, Ertekin-Taner, Nilüfer, additional, Scholz, Sonja W., additional, Ramirez, Alfredo, additional, Ruiz, Agustin, additional, Slagboom, Eline, additional, van der Flier, Wiesje M., additional, and Holstege, Henne, additional

Published
2018
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148. Diseño de una instalación solar térmica para calentamiento de agua caliente sanitaria en una residencia de mayores

Author

Guerra Macho, José Julio, Universidad de Sevilla. Departamento de Ingeniería Energética, García Rodríguez, Eloy José, Guerra Macho, José Julio, Universidad de Sevilla. Departamento de Ingeniería Energética, and García Rodríguez, Eloy José

Abstract

El siguiente trabajo trata el estudio y dimensionado de una instalación solar térmica de baja temperatura para calentamiento de ACS. El diseño de dicha instalación se ha realizado para la residencia de mayores Claret de Sevilla. Este documento consta de cinco documentos básicos: Memoria descriptiva, Memoria de cálculo, Pliegos de condiciones técnicas y administrativas, Presupuesto y Planos. La función de cada documento básico queda definida por su propio nombre, no obstante, se dedica un breve apartado al inicio de cada documento para especificar su cometido. En dicho trabajo se ha utilizado la herramienta CHEQ4, herramienta desarrollada por el IDAE y la ASIT para la validación del cumplimiento de la contribución solar mínima. Con dicha herramienta se han realizado una serie de curvas donde se puede observar las prestaciones de la instalación cuando se varía el volumen de acumulación, la superficie de captación, o ambos. El sistema completo y cada uno de sus componentes han sido dimensionados respetando la normativa vigente, cumpliendo en todo momento con el CTE.

Published
2017

149. A Pulsational Time-evolution Study for the $\delta$ Scuti Star AN Lyncis

Author

Zhou, A. -Y., Hintz, Eric G., Schoonmaker, Jeremy N., Rodríguez, Eloy, Costa, Victor, Lopez-Gonzalez, M. J., Smith, Horace A., Sanders, Nathan, Monninger, Gerold, Pagel, Lienhard, Zhou, A. -Y., Hintz, Eric G., Schoonmaker, Jeremy N., Rodríguez, Eloy, Costa, Victor, Lopez-Gonzalez, M. J., Smith, Horace A., Sanders, Nathan, Monninger, Gerold, and Pagel, Lienhard

Abstract

This paper presents a large amount of observations for the $\delta$ Scuti star AN Lyncis carried out in 2001--2012. The extensive observations include two tri-continent campaigns coordinated in 2002 and 2011, respectively, and several single-site contributions throughout the period. The data in total have more than 104100 raw CCD frames and photoelectric records, which consist of 165 nights (about 816 hours) spanning over 3778 days. The final reduced light curves have more than 26500 data points (including those 3462 unpublished BYU data), from which we determined 306 new timings of maximum light. A time-dependent behaviour study based on all available data indicates cyclic amplitude variability as well as period change [for the main periodicity]. Orbital sinusoid fittings to $(O-C)$ residuals and pulsation amplitudes may account for their variations being caused by the light-time effect of AN Lyn in a binary system. The orbital period is about 26--30 years. Current results support the binarity of AN Lyn, first suspected by Zhou (2002). We further show the detailed time evolution structure of the pulsation of AN Lyn as function of both time and period through wavelet analyses., Comment: 23 figures, 5 tables, reduced data, maxima, and raw data available. Submitted initial manuscript, in revision in response to referee's report

Published
2017

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