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104. 3:18 PM Abstract No. 139 Pathologic outcomes of hepatocellular carcinoma treated with radiation segmentectomy prior to liver transplantation

Author

Lauar Cortizo Vidal, L., primary, Olson, M., additional, Lewis, A., additional, Ritchie, C., additional, Paz-Fumagalli, R., additional, Devcic, Z., additional, Frey, G., additional, McKinney, J., additional, Croome, K., additional, Harnois, D., additional, Patel, T., additional, and Toskich, B., additional

Published
2020
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108. Irish society of gastroenterology: Proceedings of Winter Meeting held Friday 21st and Saturday 22nd November, 1997

Author

Clarke, G., Ryan, E., O’Keane, J. C., Crowe, J., McMathuna, P., Moriarty, D., Ettarh, R., Sheahan, K., Hyland, J., O’Donoghue, D. P., Baird, A. W., Clarke, G., Ryan, E., Gormley, G., Keane, J. C. O., Crowe, J., MacMathuna, P., Wang, J. H., Wu, Q. D., Redmond, H. P., Condron, C., Bouchier-Hayes, D., Nally, K., Newton, F., O’Connell, J., O’Sullivan, G. C., Morgan, J., Collins, J. K., Shanahan, F., Goode, C., O’Connell, J., O’Sullivan, G. C., Collins, J. K., Shanahan, F., Winter, D. C., Taylor, C. T., Skelly, M. M., O’Donoghue, D. P., O’Sullivan, G. C., Baird, A. W., Harvey, B. J., Varghese, J. C., Farrell, M. A., McGrath, F. P., Murray, F. E., Osborne, H., Lee, M. J., Ryan, E., Sullivan, A., O’Keane, J. C., Crowe, J., Ryan, A. E., O’Keane, J. C., Crowe, J., Donovan, A. N., McCormick, P. A., Kenny, B., Somers, S., Bohan, A., Gibney, R. G., Marcaccio, M., Malone, D. E., Doyle, M., Delaney, C. P., Gorey, T. F., McEntee, G. P., O’Sullivan, G. C., Clarke, A., Stuart, R., Kelly, J., Kiely, M. D., Collins, J. K., Shanahan, F., O’Sullivan, M., Lovett, E., Mahmud, N., Kelleher, D., O’Morain, C. A., Larkin, C. J., Watson, R. G. P., Sloan, J. M., Ardill, J. E. S., Johnston, C. F., Buchanan, K. D., Heaney, A., Collins, J. S. A., Watson, G. R. P., Kalin, R. M., Heaney, A., Collins, J. S. A., Tham, T. C. K., Watson, R. G. P., McFarland, R. J., Bamford, K. B., Cróinín, T. Ó, Clyne, M., Drumm, B., Rowland, M., Kumar, D., O’Connor, P., Daly, L. E., Drumm, B., O’Toole, D. L., Long, A., Murphy, A. M., O’Neill, L., Weir, D. G., Kelleher, D., Heaney, A., Collins, J. S. A., Watson, R. G. P., Hopkins, A. M., Moynagh, P., O’Donoghue, D. P., Baird, A. W., Brennan, C., Harmey, J., Stapleton, P. P., Redmond, H. P., Bouchier-Hayes, D., Rasheed, A. M., Chen, G., Kelly, C., Bouchier-Hayes, D. J., Leahy, A., Gallagher, M., Grace, A., Xin, Y., Leader, M., Kay, E., Whelan, A., Pattison, U., Willoughby, R., Wallace, E., Weir, D., Feighery, C., Bennett, M. W., O’Connell, J., O’Sullivan, G. C., Brady, C., Roche, D., Collins, J. K., Shanahan, F., Mahmud, N., Molloy, A., McPartlin, J., Scott, J. M., Weir, D. G., Acheson, A. G., Lee, J., Khosraviani, K., Irwin, S. T., McDaid, J., McCormick, P. A., Docherty, J. R., O’Grady, A., Kay, E., Mabruk, M., Grace, A., Leader, M., Lee, J., Acheson, A. G., Irwin, S. T., Larkin, C. J., Johnston, C., Curry, W., Ardill, J., Cunningham, R., Buchanan, K. D., Watson, R. G. P., McDougall, N. I., Coyle, P. V., Callender, M. E., Ouinn, A. M., Warner, R., Stevens, F. M., Chakravarthi, P. I. S., Kearns, M., Bourke, M., Hassan, A., McWeeney, J., Stevens, F. M., McCarthy, C. F., Casey, M., O’Donoghue, J., Eustace-Ryan, A. M., O’Regan, P., Feighery, L., Jackson, J., Cronin, N., Shanahan, F., Quane, K., Feighery, C., Mulligan, E. D., Purcell, T., Dunne, B., Griffin, M., Noonan, N., Hollywood, D., Keeling, N., Reynolds, J. V., Hennessy, T. P. J., Mulligan, E. D., Purcell, T., Dunne, B., Griffin, M., Noonan, N., Hollywood, D., Keeling, N., Reynolds, J. V., Hennessy, T. P. J., Mulligan, E. D., Purcell, T., Dunne, B., Griffin, M., Noonan, N., Hollywood, D., Keeling, N., Reynolds, J. V., Hennessy, T. P. J., Mulligan, E. D., Purcell, T., Dunne, B., Griffin, M., Noonan, N., Hollywood, D., Keeling, N., Reynolds, J. V., Hennessy, T. P. J., O’Sulhvan, M., Harman, I., Breslin, N. P., Clayton, N., O’Morain, C. A., Hogan, S., Donovan, B., Hayes, D., Kiely, M., Eustace-Ryan, A. M., O’Regan, P., Goulding, C. A., Albloushi, S. S., O’Connor, J., Courtney, M. G., Murray, F. E., Albloushi, S. S., Goulding, C. A., Kay, E., Royston, D., Leader, M., Courtney, M. G., Murray, F. E., Albloushi, S. S., Kay, E., Goulding, C. A., Grace, A., O’Connor, J., Shattock, A. G., Courtney, M. G., Murray, F. E., Albloushi, S. S., Stack, A., Kay, E., Goulding, C. A., Carmody, M., Murray, F. E., Courtney, M. G., Barrett, S., Ryan, E., O’Keane, J. C., Crowe, J., Hennigan, A., Delaney, C. P., Young, L., Shields, C. J., O’Keane, C., Gorey, T. F., Fitzpatrick, J. M., Rasheed, A. M., Wang, J. H., Kelly, C., Bouchier-Hayes, D. J., Leahy, A., Doyle, M. M., Stephens, R. B., Daly, P. A., Bennett, M. W., O’Connell, J., O’Sullivan, G. C., Brady, C., Roche, D., Collins, J. K., Shanahan, F., Briggs, G. M., McCrory, D., Briggs, G. M., McCrory, D., O’Neill, S., O’Grady, H., Grant, D. C., Barry, K., Traynor, O., Hyland, J. M. P., O’Toole, G. C., Grant, D. C., Barry, M. K., Hyland, J. M. P., Johnston, S. D., Ritchie, C. M., Robinson, T. J., Johnston, S. D., Kirby, J. M., Mackle, E. M., Robinson, T. J., Haider, N., Aherne, N., McNichol, F., Hamilton, D., Neary, P., Hegarty, S., Connor, J. O., Watson, R. G. K., Drudy, D., Alwan, A., Fenelon, L., O’Farrelly, C., Hyland, J., Byrne, B., Madrigal, L., Carton, J., Collins, C., O’Donoghue, D., O’Farrelly, C., Gannon, N., Hickey, A., O’Boyle, C. A., Byrne, R., Albloushi, S., and Murray, F.

Published
1998
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109. The Fulfillment of Hope from GENIE Continues

Author

Shoemaker, Ritchie C. and Heyman, Andrew

Subjects
Inflammation, Apoptosis
Abstract

Beginning with the storage of frozen PAXgene tubes in 2008, 'for use when the science caught up to what we learned from CIRS [chronic inflammatory response syndrome],' followed by whole [...]

Published
2019

113. The usage, quality and relevance of information and communications technologies in patients with chronic urticaria: A UCARE study

Author

Maurer, M. Weller, K. Magerl, M. Maurer, R.R. Vanegas, E. Felix, M. Cherrez, A. Mata, V.L. Kasperska-Zajac, A. Sikora, A. Fomina, D. Kovalkova, E. Godse, K. Rao, N.D. Khoshkhui, M. Rastgoo, S. Criado, R.F.J. Abuzakouk, M. Grandon, D. van Doorn, M. Valle, S.O.R. de Souza Lima, E.M. Thomsen, S.F. Ramón, G.D. Matos Benavides, E.E. Bauer, A. Giménez-Arnau, A.M. Kocatürk, E. Guillet, C. Ignacio Larco, J. Zhao, Z.-T. Makris, M. Ritchie, C. Xepapadaki, P. Ensina, L.F. Cherrez, S. Cherrez-Ojeda, I.

Abstract

Background: Chronic urticaria (CU) is characterized by itchy recurrent wheals, angioedema, or both for 6 weeks or longer. CU can greatly impact patients' physical and emotional quality of life. Patients with chronic conditions are increasingly seeking information from information and communications technologies (ICTs) to manage their health. The objective of this study was to assess the frequency of usage and preference of ICTs from the perspective of patients with CU. Methods: In this cross-sectional study, 1800 patients were recruited from primary healthcare centers, university hospitals or specialized clinics that form part of the UCARE (Urticaria Centers of Reference and Excellence) network throughout 16 countries. Patients were >12 years old and had physician-diagnosed chronic spontaneous urticaria (CSU) or chronic inducible urticaria (CIndU). Patients completed a 23-item questionnaire containing questions about ICT usage, including the type, frequency, preference, and quality, answers to which were recorded in a standardized database at each center. For analysis, ICTs were categorized into 3 groups as follows: one-to-one: SMS, WhatsApp, Skype, and email; one-to-many: YouTube, web browsers, and blogs or forums; many-to-many: Instagram, Twitter, Facebook, and LinkedIn. Results: Overall, 99.6% of CU patients had access to ICT platforms and 96.7% had internet access. Daily, 85.4% patients used one-to-one ICT platforms most often, followed by one-to-many ICTs (75.5%) and many-to-many ICTs (59.2%). The daily ICT usage was highest for web browsers (72.7%) and WhatsApp (70.0%). The general usage of ICT platforms increased in patients with higher levels of education. One-to-many was the preferred ICT category for obtaining general health information (78.3%) and for CU-related information (75.4%). A web browser (77.6%) was by far the most commonly used ICT to obtain general health information, followed by YouTube (25.8%) and Facebook (16.3%). Similarly, for CU-specific information, 3 out of 4 patients (74.6%) used a web browser, 20.9% used YouTube, and 13.6% used Facebook. One in 5 (21.6%) patients did not use any form of ICT for obtaining information on CU. The quality of the information obtained from one-to-many ICTs was rated much more often as very interesting and of good quality for general health information (53.5%) and CU-related information (51.5%) as compared to the other categories. Conclusions: Usage of ICTs for health and CU-specific information is extremely high in all countries analyzed, with web browsers being the preferred ICT platform. © 2020

Published
2020

116. Associations between vascular risk factors and brain MRI indices in UK Biobank

Author

Cox, S.R., Lyall, Donald M., Ritchie, S.J., Bastin, M.E., Harris, M.A., Buchanan, C.R., Fawns-Ritchie, C., Barbu, M.C., de Nooij, L., Reus, L.M., Alloza, C., Shen, X., Neilson, E., Alderson, H.L., Hunter, S., Liewald, D.C., Whalley, H.C., McIntosh, A.M., Lawrie, S.J., Pell, Jill P., Tucker-Drob, E.M., Wardlaw, J.M., Gale, C.R., Deary, I.J., Neurology, and Amsterdam Neuroscience - Neurodegeneration

Subjects
Adult, Male, brain, Fast Track Clinical Research, Imaging, Diffusion, Risk Factors, Humans, Aged, Biological Specimen Banks, White matter, diffusion, Brain, Middle Aged, Magnetic Resonance Imaging, United Kingdom, Editor's Choice, Cerebrovascular Disorders, cortex, Cortex, Female, vascular risk, Vascular risk, white matter, MRI
Abstract

Aims: Several factors are known to increase risk for cerebrovascular disease and dementia, but there is limited evidence on associations between multiple vascular risk factors (VRFs) and detailed aspects of brain macrostructure and microstructure in large community-dwelling populations across middle and older age. Methods and Results: Associations between VRFs (smoking, hypertension, pulse pressure, diabetes, hypercholesterolaemia, body mass index, and waist–hip ratio) and brain structural and diffusion MRI markers were examined in UK Biobank (N = 9722, age range 44–79 years). A larger number of VRFs was associated with greater brain atrophy, lower grey matter volume, and poorer white matter health. Effect sizes were small (brain structural R2 ≤1.8%). Higher aggregate vascular risk was related to multiple regional MRI hallmarks associated with dementia risk: lower frontal and temporal cortical volumes, lower subcortical volumes, higher white matter hyperintensity volumes, and poorer white matter microstructure in association and thalamic pathways. Smoking pack years, hypertension and diabetes showed the most consistent associations across all brain measures. Hypercholesterolaemia was not uniquely associated with any MRI marker.Conclusion: Higher levels of VRFs were associated with poorer brain health across grey and white matter macrostructure and microstructure. Effects are mainly additive, converging upon frontal and temporal cortex, subcortical structures, and specific classes of white matter fibres. Though effect sizes were small, these results emphasize the vulnerability of brain health to vascular factors even in relatively healthy middle and older age, and the potential to partly ameliorate cognitive decline by addressing these malleable risk factors.

Published
2019
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117. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (vol 9, 2098, 2018)

Author

Davies, G., Lam, M., Harris, S.E., Trampush, J.W., Luciano, M., Hill, W.D., Hagenaars, S.P., Ritchie, S.J., Marioni, R.E., Fawns-Ritchie, C., Liewald, D.C.M., Okely, J.A., Ahola-Olli, A.V., Barnes, C.L.K., Bertram, L., Bis, J.C., Burdick, K.E., Christoforou, A., DeRosse, P., Djurovic, S., Espeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D.E., Hayward, C., Hofer, E., Ikram, M.A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K.A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C.A., Sargurupremraj, M., Scholz, M., Smith, J.A., Smith, A.V., Terzikhan, N., Thalamuthu, A., Trompet, S., Lee, S.J. van der, Ware, E.B., Windham, B.G., Wright, M.J., Yang, J.Y., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O.A., Armstrong, N.J., Assareh, A.A., Attia, J.R., Attix, D., Avramopoulos, D., Bennett, D.A., Bohmer, A.C., Boyle, P.A., Brodaty, H., Campbell, H., Cannon, T.D., Cirulli, E.T., Congdon, E., Conley, E.D., Corley, J., Cox, S.R., Dale, A.M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J.G., Evangelou, E., Faul, J.D., Ford, I., Freimer, N.A., Gao, H., Giegling, I., Gillespie, N.A., Gordon, S.D., Gottesman, R.F., Griswold, M.E., Gudnason, V., Harris, T.B., Hartmann, A.M., Hatzimanolis, A., Heiss, G., Holliday, E.G., Joshi, P.K., Kahonen, M., Kardia, S.L.R., Karlsson, I., Kleineidam, L., Knopman, D.S., Kochan, N.A., Konte, B., Kwok, J.B., Hellard, S. le, Lee, T., Lehtimaki, T., Li, S.C., Lill, C.M., Liu, T., Koini, M., London, E., Longstreth, W.T., Lopez, O.L., Loukola, A., Luck, T., Lundervold, A.J., Lundquist, A., Lyytikainen, L.P., Martin, N.G., Montgomery, G.W., Murray, A.D., Need, A.C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R.A., Psaty, B.M., Reppermund, S., Riedel-Heller, S.G., Rose, R.J., Rotter, J.I., Roussos, P., Rovio, S.P., Saba, Y., Sabb, F.W., Sachdev, P.S., Satizabal, C.L., Schmid, M., Scott, R.J., Scult, M.A., Simino, J., Slagboom, P.E., Smyrnis, N., Soumare, A., Stefanis, N.C., Stott, D.J., Straub, R.E., Sundet, K., Taylor, A.M., Taylor, K.D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A.N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K.H., Widen, E., Yang, Q., Zhao, W., Adams, H.H.H., Arking, D.E., Bilder, R.M., Bitsios, P., Boerwinkle, E., Chiba-Falek, O., Corvin, A., Jager, P.L. de, Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A.L., Gill, M., Glahn, D.C., Hagg, S., Hansell, N.K., Hariri, A.R., Ikram, M.K., Jukema, J.W., Vuoksimaa, E., Keller, M.C., Kremen, W.S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N.L., Pendleton, N., Porteous, D.J., Raikkonen, K., Raitakari, O.T., Ramirez, A., Reinvang, I., Rudan, I., Rujescu, D., Schmidt, R., Schmidt, H., Schofield, P.W., Schofield, P.R., Starr, J.M., Steen, V.M., Trollor, J.N., Turner, S.T., Duijn, C.M. van, Villringer, A., Weinberger, D.R., Weir, D.R., Wilson, J.F., Malhotra, A., McIntosh, A.M., Gale, C.R., Seshadri, S., Mosley, T.H., Bressler, J., Lencz, T., and Deary, I.J.

Published
2019

118. Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author

Davies, G., Lam, M., Harris, S. E., TRAMPUSH, J. W., LUCIANO, M., HILL, W. D., HAGENAARS, S. P., RITCHIE, S. J., MARIONI, R. E., FAWNS-RITCHIE, C., LIEWALD, D. C. M., OKELY, J. A., AHOLA-OLLI, A. V., BARNES, C. L. K., Bertram, L., BIS, J. C., BURDICK, K. E., CHRISTOFOROU, A., DEROSSE, P., Djurovic, S., ESPESETH, T., GIAKOUMAKI, S., GIDDALURU, S., GUSTAVSON, D. E., Hayward, C., Hofer, E., KARLSSON, R., KNOWLES, E., Lahti, J., Leber, M., MATHER, K. A., Melle, I., Morris, D., OLDMEADOW, C., PALVIAINEN, T., PAYTON, A., PAZOKI, R., PETROVIC, K., Reynolds, C. A., SARGURUPREMRAJ, M., Scholz, M., Smith, J. A., SMITH, A. V., TERZIKHAN, N., THALAMUTHU, A., TROMPET, S., VAN DER LEE, S. J., WARE, E. B., WINDHAM, B. G., WRIGHT, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., ANDREASSEN, O. A., ARMSTRONG, N. J., ASSAREH, A. A., ATTIA, J. R., ATTIX, D., AVRAMOPOULOS, D., BENNETT, D. A., BOHMER, A. C., BOYLE, P. A., BRODATY, H., Campbell, H., CANNON, T. D., CIRULLI, E. T., CONGDON, E., CONLEY, E. D., CORLEY, J., COX, S. R., DALE, A. M., DEHGHAN, A., Dick, D., Dickinson, D., ERIKSSON, J. G., EVANGELOU, E., FAUL, J. D., Ford, I., FREIMER, N. A., Gao, H., Giegling, I., GILLESPIE, N. A., GORDON, S. D., GOTTESMAN, R. F., GRISWOLD, M. E., GUDNASON, V., HARRIS, T. B., HARTMANN, A. M., Hatzimanolis, A., Heiss, G., HOLLIDAY, E. G., Joshi, P. K., KAHONEN, M., KARDIA, S. L. R., KARLSSON, I., KLEINEIDAM, L., KNOPMAN, D. S., KOCHAN, N. A., Konte, B., KWOK, J. B., LE HELLARD, S., Lee, T., LEHTIMAKI, T., Li, S. C., Lill, C. M., Liu, T., KOINI, M., London, E., LONGSTRETH, W. T., Jr., LOPEZ, O. L., LOUKOLA, A., LUCK, T., LUNDERVOLD, A. J., LUNDQUIST, A., LYYTIKAINEN, L. P., Martin, N. G., MONTGOMERY, G. W., MURRAY, A. D., NEED, A. C., NOORDAM, R., Nyberg, L., OLLIER, W., PAPENBERG, G., PATTIE, A., POLASEK, O., POLDRACK, R. A., PSATY, B. M., REPPERMUND, S., RIEDEL-HELLER, S. G., ROSE, R. J., ROTTER, J. I., ROUSSOS, P., ROVIO, S. P., SABA, Y., SABB, F. W., SACHDEV, P. S., SATIZABAL, C. L., Schmid, M., Scott, R. J., SCULT, M. A., SIMINO, J., SLAGBOOM, P. E., SMYRNIS, N., Soumare, A., Stefanis, N. C., STOTT, D. J., STRAUB, R. E., SUNDET, K., Taylor, A. M., TAYLOR, K. D., TZOULAKI, I., Tzourio, C., Uitterlinden, A., Vitart, V., VOINESKOS, A. N., Kaprio, J., Wagner, M., Wagner, H., WEINHOLD, L., WEN, K. H., WIDEN, E., Yang, Q., Zhao, W., ADAMS, H. H. H., ARKING, D. E., Bilder, R. M., BITSIOS, P., BOERWINKLE, E., CHIBA-FALEK, O., Corvin, A., DE JAGER, P. L., Debette, S., Donohoe, G., Elliott, P., FITZPATRICK, A. L., Gill, M., GLAHN, D. C., HAGG, S., HANSELL, N. K., HARIRI, A. R., Ikram, M. A., JUKEMA, J. W., VUOKSIMAA, E., KELLER, M. C., KREMEN, W. S., LAUNER, L., LINDENBERGER, U., Palotie, A., PEDERSEN, N. L., PENDLETON, N., PORTEOUS, D. J., RAIKKONEN, K., RAITAKARI, O. T., Ramirez, A., REINVANG, I., RUDAN, I., DAN, Rujescu, Schmidt, R., Schmidt, H., SCHOFIELD, P. W., STARR, J. M., STEEN, V. M., TROLLOR, J. N., TURNER, S. T., VAN DUIJN, C. M., VILLRINGER, A., WEINBERGER, D. R., WEIR, D. R., WILSON, J. F., Malhotra, A., MCINTOSH, A. M., GALE, C. R., SESHADRI, S., MOSLEY, T. H., Jr., BRESSLER, J., Lencz, T., DEARY, I. J., Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
VINTAGE, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, HEALTHY, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.

Published
2019
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123. Irish endocrine society: Proceedings of 18th annual meeting held at Cork Regional Hospital, Wilton, Cork on November 5th & 6th, 1993

Author

Dimitriadis, E., Owens, D., Collins, P., Johnson, A., Tomkin, G., Cronin, C. C., Barry, D., Crowley, B., Ferriss, J. B., Hetherton, A. M., Smith, D. F., O’Herlihy, C., Smyth, P. P. A., Fiad, T. M., Culliton, M., Dunbar, J., Cunningham, S. K., McKenna, T. J., Heaney, A. P., Loughrey, G. L., McCance, D. R., Mcllrath, E., Hadden, D. R., Kennedy, L., Sheridan, B., Ferris, J. B., Whyte, A., Cleary, P. E., McAuley, D. J., Mathew, B., Bailey, I. C., Curtin, A., Lenehan, K., Deegan, P., Henry, M., Stapleton, M., Baker, H., Duggan, P. F., Mitchell, T. H., O’Hare, J. A., Geoghegan, M., Abuaisha, F., Fearon, U., Clarke, D., Roberts, R. N., Traub, A. I., Thompson, W., Whitehead, H., Holmes, J., Roberts, R., Al-Mandhari, N. A., Greer, A., Carson, D., Traub, T., Hadden, D., Heaney, A. P., Ferguson, T., Atkinson, A. B., O’Keeffe, S., Devlin, J. G., Donnellan, C., Russell, C. R., Kennedy, T. L., Kennedy, A. L., Atkinson, A. B., Long, H. A., Conway, D. J., Mercer, P. M., Murphy, D., Stokes, M., Sheahan, K., O’Higgins, N. J., Dunne, F. P., Ratcliffe, W. A., Mansour, P., Heath, D. A., O’Meara, N. M., Sturis, J., Herold, K. C., Polonsky, K. S., Beatty, O. L., Ritchie, C. M., Bell, P. M., Kennedy, A. L., Clarke, D., Fearon, U., Levy, J. C., Turkington, E., Hadden, D. W., Harper, R., Ennis, C. N., Johnston, G. D., Scanlan, P., Foley, M., Stronge, J., Firth, R., Hanson, R. L., Jacobsson, L. T. H., Bennett, P. H., Bishop, D. T., and Knowler, W. C.

Published
1994
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124. The usage, quality and relevance of information and communications technologies in patients with chronic urticaria: A UCARE study

Author

Maurer, M., Weller, K., Magerl, M., Maurer, R.R., Vanegas, E., Felix, M., Cherrez, A., Mata, V.L., Kasperska-Zajac, A., Sikora, A., Fomina, D., Kovalkova, E., Godse, K., Rao, N.D., Khoshkhui, M., Rastgoo, S., Criado, R.F.J., Abuzakouk, M., Grandon, D., van Doorn, M., Valle, S.O.R., de Souza Lima, E.M., Thomsen, S.F., Ramón, G.D., Matos Benavides, E.E., Bauer, A., Giménez-Arnau, A.M., Kocatürk, E., Guillet, C., Ignacio Larco, J., Zhao, Z.T., Makris, M. (M.), Ritchie, C, Xepapadaki, P., Ensina, L.F., Cherrez, S., Cherrez-Ojeda, I., Maurer, M., Weller, K., Magerl, M., Maurer, R.R., Vanegas, E., Felix, M., Cherrez, A., Mata, V.L., Kasperska-Zajac, A., Sikora, A., Fomina, D., Kovalkova, E., Godse, K., Rao, N.D., Khoshkhui, M., Rastgoo, S., Criado, R.F.J., Abuzakouk, M., Grandon, D., van Doorn, M., Valle, S.O.R., de Souza Lima, E.M., Thomsen, S.F., Ramón, G.D., Matos Benavides, E.E., Bauer, A., Giménez-Arnau, A.M., Kocatürk, E., Guillet, C., Ignacio Larco, J., Zhao, Z.T., Makris, M. (M.), Ritchie, C, Xepapadaki, P., Ensina, L.F., Cherrez, S., and Cherrez-Ojeda, I.

Abstract

Background: Chronic urticaria (CU) is characterized by itchy recurrent wheals, angioedema, or both for 6 weeks or longer. CU can greatly impact patients' physical and emotional quality of life. Patients with chronic conditions are increasingly seeking information from information and communications technologies (ICTs) to manage their health. The objective of this study was to assess the frequency of usage and preference of ICTs from the perspective of patients with CU. Methods: In this cross-sectional study, 1800 patients were recruited from primary healthcare centers, university hospitals or specialized clinics that form part of the UCARE (Urticaria Centers of Reference and Excellence) network throughout 16 countries. Patients were >12 years old and had physician-diagnosed chronic spontaneous urticaria (CSU) or chronic inducible urticaria (CIndU). Patients completed a 23-item questionnaire containing questions about ICT usage, including the type, frequency, preference, and quality, answers to which were recorded in a standardized database at each center. For analysis, ICTs were categorized into 3 groups as follows: one-to-one: SMS, WhatsApp, Skype, and email; one-to-many: YouTube, web browsers, and blogs or forums; many-to-many: Instagram, Twitter, Facebook, and LinkedIn. Results: Overall, 99.6% of CU patients had access to ICT platforms and 96.7% had internet access. Daily, 85.4% patients used one-to-one ICT platforms most often, followed by one-to-many ICTs (75.5%) and many-to-many ICTs (59.2%). The daily ICT usage was highest for web browsers (72.7%) and WhatsApp (70.0%). The general usage of ICT platforms increased in patients with higher levels of education. One-to-many was the preferred ICT category for obtaining general health information (7

Published
2020
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125. Dementia Research Fit for the Planet: Reflections on Population Studies of Dementia for Researchers and Policy Makers Alike

Author

Brayne, C.E. (Carol E.), Barnes, L.E. (Linda E.), Breteler, M.M.B. (Monique M.B.), Brooks, R.L. (Rachael L.), Dufouil, C. (Carole), Fox, C. (Chris), Fratiglioni, L. (Laura), Ikram, M.A. (Arfan), Kenny, R.A. (Rose A.), Kivipelto, M. (Miia), Lobo, A. (Antonio), Musicco, M. (Massimo), Qiu, C. (Chengxuan), Richard, E. (Edo), Riedel-Heller, S. (Steffi), Ritchie, C. (Craig), Skoog, I., Stephan, B.C.M., Venneri, A. (Annalena), Matthews, F.E. (Fiona), Brayne, C.E. (Carol E.), Barnes, L.E. (Linda E.), Breteler, M.M.B. (Monique M.B.), Brooks, R.L. (Rachael L.), Dufouil, C. (Carole), Fox, C. (Chris), Fratiglioni, L. (Laura), Ikram, M.A. (Arfan), Kenny, R.A. (Rose A.), Kivipelto, M. (Miia), Lobo, A. (Antonio), Musicco, M. (Massimo), Qiu, C. (Chengxuan), Richard, E. (Edo), Riedel-Heller, S. (Steffi), Ritchie, C. (Craig), Skoog, I., Stephan, B.C.M., Venneri, A. (Annalena), and Matthews, F.E. (Fiona)

Abstract

In recent years, a rapidly increasing collection of investigative methods in addition to changes in diagnostic criteria for dementia have followed "high-tech" trends in medicine, with the aim to better define the dementia syndrome and its biological substrates, mainly in order to predict risk prior to clinical expression. These approaches are not without challenge. A set of guidelines have been developed by a group of European experts in population-based cohort research through a series of workshops, funded by the Joint Program for Neurodegenerative Disorders (JPND). The aims of the guidelines are to assist policy makers and researchers to understand (1) What population studies for ageing populations should encompass and (2) How to interpret the findings from population studies. Such studies are essential to provide evidence relevant to the understanding of healthy and frail brain ageing, including the dementia syndrome for contemporary and future societies by drawing on the past.

Published
2020
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126. Incorporation of Vanadium and Molybdenum into Yttrium-Arsenotungstates Supported by Amino Acid Ligands

Author

Bagherjeri, FA, Ritchie, C, Gable, RW, Bryant, G, Boskovic, C, Bagherjeri, FA, Ritchie, C, Gable, RW, Bryant, G, and Boskovic, C

Abstract

The preference for incorporation of molybdenum over tungsten into specific sites of a family of yttrium-arsenotungstates with amino acid ligands prompted exploration of the incorporation of other metals, affording three new vanadium-containing (V/W and V/Mo/W) analogues: K2(GlyH)10[As4(V2W2)W44Y4O160(Gly)8(H2O)12]·11Gly (1), (MBAH)9(L-NleH)3[As4(V2W2)W44Y4O160(L-Nle)8(H2O)12] (2), and (MBAH)9(L-NleH)3[As4(V2W2)Mo2W42Y4O160(L-Nle)8(H2O)12] (3) (Gly=glycine and L-Nle=l-norleucine, MBAH=4-methylbenzylammonium). These hybrid polyoxometalates all possess a tetrametallic oxo-bridged {VIV2WVI2} central core surrounded by an amino acid-ligated cyclic metal-oxo framework. X-Ray photoelectron, UV-visible reflectance, and electron paramagnetic resonance spectroscopy, together with metal analysis, confirm the incorporation of vanadium into the polyoxometalates, while single crystal X-ray diffraction analysis supports the location of the vanadium atoms in the central core.

Published
2020

127. Dementia Research Fit for the Planet: Reflections on Population Studies of Dementia for Researchers and Policy Makers Alike

Author

Brayne, CE, Barnes, LE, Breteler, MMB, Brooks, RL, Dufouil, C, Fox, C, Fratiglioni, L, Ikram, Arfan, Kenny, RA, Kivipelto, M, Lobo, A, Musicco, M, Qiu, C, Richard, E, Riedel-Heller, SG, Ritchie, C, Skoog, I, Stephan, BC, Venneri, A, Matthews, FE, Brayne, CE, Barnes, LE, Breteler, MMB, Brooks, RL, Dufouil, C, Fox, C, Fratiglioni, L, Ikram, Arfan, Kenny, RA, Kivipelto, M, Lobo, A, Musicco, M, Qiu, C, Richard, E, Riedel-Heller, SG, Ritchie, C, Skoog, I, Stephan, BC, Venneri, A, and Matthews, FE

Published
2020

128. The usage, quality and relevance of information and communications technologies in patients with chronic urticaria: A UCARE study

Author

Maurer, M, Weller, K, Magerl, M, Maurer, RR, Vanegas, E, Felix, M, Cherrez, A, Mata, VL, Kasperska-Zajac, A, Sikora, A, Fomina, D, Kovalkova, E, Godse, K, Rao, ND, Khoshkhui, M, Rastgoo, S, Criado, RFJ, Abuzakouk, M, Grandon, D, van Doorn, Martijn, Valle, SOR, de Souza Lima, EM, Thomsen, SF, Ramón, GD, Matos Benavides, EE, Bauer, A, Giménez-Arnau, AM, Kocatürk, E, Guillet, C, Ignacio Larco, J, Zhao, ZT, Makris, M, Ritchie, C, Xepapadaki, P, Ensina, LF, Cherrez, S, Cherrez-Ojeda, I, Maurer, M, Weller, K, Magerl, M, Maurer, RR, Vanegas, E, Felix, M, Cherrez, A, Mata, VL, Kasperska-Zajac, A, Sikora, A, Fomina, D, Kovalkova, E, Godse, K, Rao, ND, Khoshkhui, M, Rastgoo, S, Criado, RFJ, Abuzakouk, M, Grandon, D, van Doorn, Martijn, Valle, SOR, de Souza Lima, EM, Thomsen, SF, Ramón, GD, Matos Benavides, EE, Bauer, A, Giménez-Arnau, AM, Kocatürk, E, Guillet, C, Ignacio Larco, J, Zhao, ZT, Makris, M, Ritchie, C, Xepapadaki, P, Ensina, LF, Cherrez, S, and Cherrez-Ojeda, I

Published
2020

129. Inaugural national scientific medical meeting

Author

Cooke, T. T., Sheahan, R., Foley, D., D’Arcy, G., Gibney, M., Jauch, W., Gearty, G., Crean, P., Walsh, M., Murchan, P. M., O’Donoghue, M. K., Marks, P., Leen, E. J., Shanik, G. D., Feely, T. M., O’Riordan, J., Kellett, J. G., Sheahan, N. F., MacMahon, M., Colgan, M., Walsh, J. B., .Shanik, G, Moore, R., Malone, J. F., Coakley, D., Subareddy, K., Hurley, J., McGovern, E., Sullivan, P. A., O’Mahony, S., Carroll, K., Chua, A., Keeling, R. W. N., O’Kane, A., Dinan, T., Collins, J. K., O’Sullivan, G., Hahnvajanawong, C., McCarthy, M., O’Brien, F., Collins, R. A., Beattie, S., Hamilton, H., O’Morain, C. A., Lynch, S., Murphy, A., Weir, D. G., Feighery, C., O’Farrelly, C., Kelleher, D., Murphy, D., O’Brien, M., Harte, P., Shahi, C. N., Fan, X. J., Huang, J., Smyth, C. J., McDevitt, J., Keeling, P. W. N., Cleary, M., Morrow, G., O’Loughlin, S., Murphy, G. M., Elder, G., Abouzakouk, M., Casey, E., Veale, D., Fitzgerald, O., Bradford, A., O’Regan, R. G., Nolan, P., McKeogh, D., Howell, F., O’Connor, C. M., Rook, G., FitzGerald, M. X., Power, C., Sreenan, S., Poulter, L. W., Burke, C. M., Shanahan, P., O’Donnell, N., Birthistle, K., O’Mahony, M., Shattock, A. G., Hillery, I. B., Bolger, C., Sheehan, N., Hutchinson, M., Phillips, J. P., Malone, J., Esmonde, T. F. G., Will, R. G., Faller, D., Ryan, M. P., Manning, B., Martin, F., McCormack, P. M. E., McGrath, A., Lawlor, R., Donegan, C., Boyce, C., O’Neill, D., Smith, S., Moloney, C., Feely, J., Stanton, A., Atkins, N., O’Brien, E., O’Malley, K., Gough, D. B., Jordan, A., Mannick, J. A., Rodrick, M. L., McCarthy, E., Cooney, C. M., Bourke, J., Phelan, D. M., Robertson, A. M., McShane, A. J., Buggy, D., Breathnach, A., Keogh, B., Coole†, T., Behan, P. O., Cavanagh, H. M. A., Gow, J. W., Simpson, K., Behan, W. M. H., Foley, M., Firth, R., Stronge, J., Bonnar, J., Sheppard, B. L., McClelland, R. J., Watson, D. R., Lawless, V., Houston, H. G., Adams, D., Fitzpatrick, C., Keary, K., Jennings, S., Matthews, T. G., Gormally, S., O’Regan, M., Ward, O. C., Kehoe, S., Luesley, D., Chan, K., Ward, K., Cox, M., Caird, J., Owens, D., Gilligan, S., McBrinn, S., Collins, P., Johnson, A., Tomkin, G., Fiad, T. M., Culliton, M., McKenna, T. J., Collins, P. B., Tomkin, G. H., Stinson, J. C., Clancy, L., Shannon, A., Lucey, M., Cooney, M., Stinson, J., Corcoran, P., Kelly, P., Hayes, C., Laffoy, M., McKnight, J. A., McCance, D. R., O’Hare, F., Wisdom, B., Hayes, J. R., Thornton, L., Fogarty, J., O’Flanagan, D., Corcoran, R., O’Mahony, D., Rowan, M., Clyne, M. G., Duffy, M. J., Davis, M., Kelly, D. G., Quinlan, D. M., Corbally, N., Keane, M. M., Grogan, L., Dervan, P. A., Carney, D. N., Duffy, K., Nugent, A., McDermott, E. W. M., O’Higgins, N. J., Fennelly, J. J., Atkinson, A. B., Ferrett, C. G., Leslie, H., Mcllrath, E. M., Ritchie, C. M., Russell, C. F. J., Sheridan, B., Bashyam, M., O’Sullivan, N., Baker, H., Duggan, P. F., Mitchell, T. H., Beatty, O., Browne, J., Clarke, K., Bell, P. M., Devlin, J. G., Laski, J., O’Neill, S., Redington, F., Dominique, A. V., Scanlan, P., Firth, R. G. R., Fiad, T., Freaney, R., Murray, B., McKenna, M. J., Murphy, J., Love, Wm. C., Cunningham, S. K., Crothers, J. G., McIlrath, E., Chiardha, F. Ni, Gebruers, E. M., Hall, W. J., Hegarty, D. A., O’Hare, J., Geoghegan, M., Abuaisha, F., Passmore, A. P., Whitehead, E. M., Crawford, V., Johnson, G. D., Gallagher, H. G., Stokes, M., Plank, L., Knight, G., Mitra, S., Hill, G., Buckley, P., O’Callaghan, E., Redmond, O., Stack, J. T., Ennis, J. T., Waddington, J. L., Larkin, C., Cannon, M., Byrne, M., Cotter, D., Sham, P., Colgan, K., Walsh, D., Gillian, A. M., Byrne, N., Breen, K. C., Lane, A., Mulvaney, F., Wadding-ton, J. L., Walsh, D., Lawlor, B. A., Colohan, H. A., Walshe, D., Gibson, T., Ronayne, E., Maguire, T. M., Staunton, H., Coughlin, A., Ming, P. Shu, Phillips, J., Youssef, H. A., Adebayo, G., Feely, G., Daly, S. A., Fennell, J. S., Coakley, F., Johnson, Z., Hall, M., McCormack, P. M., Martin, M., O’Connor, M., Curley, P., O’Connell, Y., Mulryan, G., Meenan, E., Kelly, J., Kilfeather, S., Cotter, T., McGlynn, H., Gharbháin, F. Ó, Chambers, P. L., Campbell, H., Stout, R. W., Hegarty, V., Scott, T., Keane, C. T., Healy, M., O’Moore, R. R., Coakley, D., Mulkerin, E., Brain, A., Hampton, D., Penney, M., Woodhouse, K., and Treacy, F.

Published
1993
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132. Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers

Author

Vergallo, A, Bun, R, Toschi, N, Baldacci, F, Zetterberg, H, Blennow, K, Cavedo, E, Lamari, F, Habert, M, Dubois, B, Floris, R, Garaci, F, Lista, S, Hampel, H, Audrain, C, Auffret, A, Bakardjian, H, Batrancourt, B, Benakki, I, Benali, H, Bertin, H, Bertrand, A, Boukadida, L, Cacciamani, F, Causse, V, Cherif Touil, S, Chiesa, Pa, Colliot, O, Dalla Barba, G, Depaulis, M, Dos Santos, A, Dubois, M, Epelbaum, S, Fontaine, B, Francisque, H, Gagliardi, G, Genin, A, Genthon, R, Glasman, P, Gombert, F, Habert, Mo, Hewa, H, Houot, M, Jungalee, N, Kas, A, Kilani, M, La Corte, V, Le Roy, F, Lehericy, S, Letondor, C, Levy, M, Lowrey, M, Ly, J, Makiese, O, Masetti, I, Mendes, A, Metzinger, C, Michon, A, Mochel, F, Nait Arab, R, Nyasse, F, Perrin, C, Poirier, F, Poisson, C, Potier, Mc, Ratovohery, S, Revillon, M, Rojkova, K, Santos-Andrade, K, Schindler, R, Servera, Mc, Seux, L, Simon, V, Skovronsky, D, Thiebaut, M, Uspenskaya, O, Vlaincu, M, Aguilar, Lf, Babiloni, C, Benda, N, Black, Kl, Bokde, Alw, Bonuccelli, U, Broich, K, Bun, Rs, Cacciola, F, Castrillo, J, Ceravolo, R, Coman, Cm, Corvol, Jc, Cuello, Ac, Cummings, Jl, Depypere, H, Duggento, A, Durrleman, S, Escott-Price, V, Federoff, H, Ferretti, Mt, Fiandaca, M, Frank, Ra, George, N, Giorgi, Fs, Graziani, M, Haberkamp, M, Herholz, K, Karran, E, Kim, Sh, Koronyo, Y, Koronyo-Hamaoui, M, Langevin, T, Lehéricy, S, Lorenceau, J, Mapstone, M, Neri, C, Nisticò, R, Nyasse-Messene, F, O'Bryant, Se, Perry, G, Ritchie, C, Rossi, S, Santarnecchi, E, Schneider, Ls, Sporns, O, Verdooner, Sr, Villain, N, Welikovitch, L, Woodcock, J, Younesi, E, Vergallo, A., Bun, R. -S., Toschi, N., Baldacci, F., Zetterberg, H., Blennow, K., Cavedo, E., Lamari, F., Habert, M. -O., Dubois, B., Floris, R., Garaci, F., Lista, S., Hampel, H., Audrain, C., Auffret, A., Bakardjian, H., Batrancourt, B., Benakki, I., Benali, H., Bertin, H., Bertrand, A., Boukadida, L., Cacciamani, F., Causse, V., Cherif Touil, S., Chiesa, P. A., Colliot, O., Dalla Barba, G., Depaulis, M., Dos Santos, A., Dubois, M., Epelbaum, S., Fontaine, B., Francisque, H., Gagliardi, G., Genin, A., Genthon, R., Glasman, P., Gombert, F., Habert, M. O., Hewa, H., Houot, M., Jungalee, N., Kas, A., Kilani, M., La Corte, V., Le Roy, F., Lehericy, S., Letondor, C., Levy, M., Lowrey, M., Ly, J., Makiese, O., Masetti, I., Mendes, A., Metzinger, C., Michon, A., Mochel, F., Nait Arab, R., Nyasse, F., Perrin, C., Poirier, F., Poisson, C., Potier, M. C., Ratovohery, S., Revillon, M., Rojkova, K., Santos-Andrade, K., Schindler, R., Servera, M. C., Seux, L., Simon, V., Skovronsky, D., Thiebaut, M., Uspenskaya, O., Vlaincu, M., Aguilar, L. F., Babiloni, C., Benda, N., Black, K. L., Bokde, A. L. W., Bonuccelli, U., Broich, K., Bun, R. S., Cacciola, F., Castrillo, J., Ceravolo, R., Coman, C. M., Corvol, J. C., Cuello, A. C., Cummings, J. L., Depypere, H., Duggento, A., Durrleman, S., Escott-Price, V., Federoff, H., Ferretti, M. T., Fiandaca, M., Frank, R. A., George, N., Giorgi, F. S., Graziani, M., Haberkamp, M., Herholz, K., Karran, E., Kim, S. H., Koronyo, Y., Koronyo-Hamaoui, M., Langevin, T., Lorenceau, J., Mapstone, M., Neri, C., Nistico, R., Nyasse-Messene, F., O'Bryant, S. E., Perry, G., Ritchie, C., Rossi, S., Santarnecchi, E., Schneider, L. S., Sporns, O., Verdooner, S. R., Villain, N., Welikovitch, L., Woodcock, J., and Younesi, E.

Subjects
0301 basic medicine, Epidemiology, Alzheimer's disease, Amyloid PET, Cerebrospinal fluid, Monocentric, Preclinical, Subjective memory complainers, SUVR, Synergistic, Tau protein, α-Synuclein, chemistry.chemical_compound, 0302 clinical medicine, biology, Health Policy, Settore FIS/07, Settore BIO/14, Pathophysiology, Psychiatry and Mental health, medicine.symptom, medicine.medical_specialty, Amyloid, Asymptomatic, 03 medical and health sciences, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology (clinical), Geriatrics and Gerontology, Psychiatry and Mental Health, Internal medicine, mental disorders, medicine, Dementia, Alpha-synuclein, business.industry, Alzheimer's disease biomarkers, medicine.disease, 030104 developmental biology, Endocrinology, nervous system, chemistry, Subjective memory complainer, biology.protein, business, 030217 neurology & neurosurgery
Abstract

Introduction Several neurodegenerative brain proteinopathies, including Alzheimer's disease (AD), are associated with cerebral deposition of insoluble aggregates of α-synuclein. Previous studies reported a trend toward increased cerebrospinal fluid (CSF) α-synuclein (α-syn) concentrations in AD compared with other neurodegenerative diseases and healthy controls. Methods The pathophysiological role of CSF α-syn in asymptomatic subjects at risk of AD has not been explored. We performed a large-scale cross-sectional observational monocentric study of preclinical individuals at risk for AD (INSIGHT-preAD). Results We found a positive association between CSF α-syn concentrations and brain β-amyloid deposition measures as mean cortical standard uptake value ratios. We demonstrate positive correlations between CSF α-syn and both CSF t-tau and p-tau 181 concentrations. Discussion Animal models presented evidence, indicating that α-syn may synergistically and directly induce fibrillization of both tau and β-amyloid. Our data indicate an association of CSF α-syn with AD-related pathophysiological mechanisms, during the preclinical phase of the disease.

Published
2018

133. Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer’s disease

Author

Hampel, H, Vergallo, A, Afshar, M, Akman-Anderson, L, Arenas, J, Benda, N, Batrla, R, Broich, K, Caraci, F, Cuello, Ac, Emanuele, E, Haberkamp, M, Kiddle, Sj, Lucia, A, Mapstone, M, Verdooner, Sr, Woodcock, J, Lista, S, Aguilar, Lf, Babiloni, C, Baldacci, F, Black, Kl, Bokde, Alw, Bonuccelli, U, Cacciola, F, Castrillo, J, Cavedo, E, Ceravolo, R, Chiesa, Pa, Corvol, J, Cummings, Jl, Depypere, H, Dubois, B, Duggento, A, Escott-Price, V, Federoff, H, Ferretti, Mt, Fiandaca, M, Frank, Ra, Garaci, F, Geerts, H, Giorgi, Fs, Goetzl, Ej, Graziani, M, Habert, M, Herholz, K, Kapogiannis, D, Karran, E, Kim, Sh, Koronyo, Y, Koronyo-Hamaoui, M, Langevin, T, Lehericy, S, Lorenceau, J, Mango, D, Neri, C, Nistico, R, O'Bryant, Se, Palermo, G, Perry, G, Ritchie, C, Rossi, S, Saidi, A, Santarnecchi, E, Schneider, Ls, Sporns, O, Toschi, N, Villain, N, Welikovitch, La, and Younesi, E

Subjects
biomarker-drug codevelopment, Systems biology, Alzheimer's disease, systems biology, precision medicine, blood-based biomarker, context of use, pathophysiology, clinical trial, predictive biomarker, Druggability, Eligibility Determination, Disease, Computational biology, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Alzheimer Disease, Humans, Medicine, Clinical Trials as Topic, business.industry, Clinical study design, Settore FIS/07, Precision medicine, Treatment efficacy, 030227 psychiatry, Clinical trial, Early Diagnosis, Alzheimer’s disease, DECIPHER, Original Article, business, Biomarkers
Abstract

Alzheimer's disease (AD)-a complex disease showing multiple pathomechanistic alterations-is triggered by nonlinear dynamic interactions of genetic/epigenetic and environmental risk factors, which, ultimately, converge into a biologically heterogeneous disease. To tackle the burden of AD during early preclinical stages, accessible blood-based biomarkers are currently being developed. Specifically, next-generation clinical trials are expected to integrate positive and negative predictive blood-based biomarkers into study designs to evaluate, at the individual level, target druggability and potential drug resistance mechanisms. In this scenario, systems biology holds promise to accelerate validation and qualification for clinical trial contexts of use-including proof-of-mechanism, patient selection, assessment of treatment efficacy and safety rates, and prognostic evaluation. Albeit in their infancy, systems biology-based approaches are poised to identify relevant AD "signatures" through multifactorial and interindividual variability, allowing us to decipher disease pathophysiology and etiology. Hopefully, innovative biomarker-drug codevelopment strategies will be the road ahead towards effective disease-modifying drugs. .La Enfermedad de Alzheimer (EA) es una enfermedad compleja que presenta múltiples alteraciones patomecánicas, que se desencadena por interacciones dinámicas no lineales de factores de riesgo genéticos / epigenéticos y ambientales, los que, en definitiva, convergen en una enfermedad biológicamente heterogénea. Para hacer frente a la carga de la EA durante las etapas preclínicas tempranas, actualmente se están desarrollando biomarcadores sanguíneos de fácil accesibilidad. Específicamente, se espera que los ensayos clínicos de próxima generación integren biomarcadores sanguíneos predictivos tanto positivos como negativos en los diseños de los estudios para evaluar, a nivel individual, la capacidad de la droga objetivo y los posibles mecanismos de resistencia a los medicamentos. En este contexto, la biología de sistemas promete acelerar la validación y la calificación de su empleo en los ensayos clínicos, incluida la prueba del mecanismo, la selección de pacientes, la evaluación de la eficacia del tratamiento y los porcentajes de seguridad, y la evaluación pronóstica. A pesar de estar en sus comienzos, los enfoques basados en la biología de sistemas están preparados para identificar “firmas” de EA relevantes a través de la variabilidad multifactorial e interindividual, lo que nos permite descifrar la fisiopatología y la etiología de la enfermedad. Ojalá, las estrategias innovadoras conjuntas del desarrollo de biomarcadores y de medicamentos sean el camino adecuado para conseguir fármacos eficaces que modifiquen la enfermedad.La maladie d’Alzheimer (MA) — maladie complexe présentant des altérations nombreuses pathomécaniques — est déclenchée par des interactions dynamiques non linéaires entre des facteurs de risques génétiques et épigénétiques et environnementaux qui, au bout du compte, aboutissent à une maladie biologiquement hétérogène. Pour réduire la charge de morbidité de la MA durant ses premiers stades précliniques, des biomarqueurs sanguins sont actuellement développés. Spécifiquement, la prochaine génération d’essais cliniques devrait intégrer ces biomarqueurs sanguins positifs ou négatifs prédictifs de la maladie dans des études qui auront pour but d’évaluer, à un niveau individuel, des cibles pouvant être traitées par des candidats médicaments et de potentiels mécanismes de résistance à ces médicaments. Dans ce contexte, la biologie des systèmes devrait permettre d’accélérer la validation et la qualification de leur utilisation dans les études cliniques – incluant la preuve du mécanisme d’action, la sélection des patients, la confirmation de l’efficacité du traitement et son niveau de sécurité, ainsi que l’évaluation pronostique. Bien que nous en soyons au tout début, les approches reposant sur la biologie des systèmes sont sur le point d’identifier des « signatures » pertinentes de la MA grâce à des variables multifactorielles et interindividuelles, qui nous permettront d’élucider la pathophysiologie et l’étiologie de la maladie. Avec un peu de chance, les stratégies innovantes de codéveloppement de biomarqueurs et de médicaments nous mèneront vers des médicaments efficaces pour lutter contre la maladie.

Published
2019

134. Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD

Author

Vergallo, A., Houot, M., Cavedo, E., Lemercier, P., Vanmechelen, E., De Vos, A., Habert, M. -O., Potier, M. -C., Dubois, B., Lista, S., Hampel, H., Bakardjian, H., Benali, H., Bertin, H., Bonheur, J., Boukadida, L., Boukerrou, N., Chiesa, P., Colliot, O., Dubois, M., Epelbaum, S., Gagliardi, G., Genthon, R., Habert, M. O., Kas, A., Lamari, F., Levy, M., Metzinger, C., Mochel, F., Nyasse, F., Poisson, C., Potier, M. C., Revillon, M., Santos, A., Andrade, K. S., Sole, M., Surtee, M., Thiebaud de Schotten, M., Younsi, N., Afshar, M., Flores Aguilar, L., Akman-Anderson, L., Arenas, J., Avila, J., Babiloni, C., Baldacci, F., Batrla, R., Benda, N., Black, K. L., Bokde, A. L. W., Bonuccelli, U., Broich, K., Cacciola, F., Caraci, F., Castrillo, J., Ceravolo, R., Chiesa, P. A., Corvol, J. -C., Claudio Cuello, A., Cummings, J. L., Depypere, H., Duggento, A., Emanuele, E., Escott-Price, V., Federoff, H., Teresa Ferretti, M., Fiandaca, M., Frank, R. A., Garaci, F., Geerts, H., Giorgi, F. S., Goetzl, E. J., Graziani, M., Haberkamp, M., Marie-Odile, H., Herholz, K., Hernandez, F., Kapogiannis, D., Karran, E., Kiddle, S. J., Kim, S. H., Koronyo, Y., Koronyo-Hamaoui, M., Langevin, T., Lehericy, S., Lucia, A., Lorenceau, J., Mango, D., Mapstone, M., Neri, C., Nistico, R., O'Bryant, S. E., Palermo, G., Perry, G., Ritchie, C., Rossi, S., Saidi, A., Santarnecchi, E., Schneider, L. S., Sporns, O., Toschi, N., Verdooner, S. R., Villain, N., Welikovitch, L. A., Woodcock, J., Younesi, E., Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 AMP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière] (CIC Neurosciences), Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Service de médecine nucléaire [CHU Pitié-Salpétrière]

Subjects
Male, 0301 basic medicine, Apolipoprotein E, Epidemiology, [SDV]Life Sciences [q-bio], PROGRESSION, Disease, Cognition, 0302 clinical medicine, Amyloid precursor protein, Medicine and Health Sciences, Aspartic Acid Endopeptidases, medicine.diagnostic_test, biology, Health Policy, Settore BIO/14, Brain, Alzheimer's disease, Healthy Volunteers, 3. Good health, GENOTYPE, ALZHEIMERS-DISEASE, Psychiatry and Mental health, Positron emission tomography, Cohort, Biomarker (medicine), Female, EXPRESSION, medicine.medical_specialty, BIOMARKERS, Standardized uptake value, 03 medical and health sciences, Cellular and Molecular Neuroscience, Sexual dimorphism, Apolipoproteins E, Sex Factors, Developmental Neuroscience, Alzheimer Disease, Internal medicine, mental disorders, medicine, Humans, BACE1 biomarkers, Aged, Plasma BACE1, DECLINE, Amyloid beta-Peptides, business.industry, 030104 developmental biology, Endocrinology, Positron-Emission Tomography, Disease modifying, biology.protein, Neurology (clinical), Amyloid Precursor Protein Secretases, Geriatrics and Gerontology, business, Biomarkers, 030217 neurology & neurosurgery
Abstract

Introduction: Successful development of effective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1)-targeted therapies for early stages of Alzheimer's disease requires biomarker-guided intervention strategies. Methods: We investigated whether key biological factors such as sex, apolipoprotein E (APOE epsilon 4) allele, and age affect longitudinal plasma BACE1 concentrations in a large monocenter cohort of individuals at risk for Alzheimer's disease. We explored the relationship between plasma BACE1 concentrations and levels of brain amyloid-beta (A beta) deposition, using positron emission tomography global standard uptake value ratios. Results: Baseline and longitudinal mean concentrations of plasma BACE1 were significantly higher in women than men. We also found a positive significant impact of plasma BACE1 on baseline A beta-positron emission tomography global standard uptake value ratios. Discussion: Our results suggest a sexual dimorphism in BACE1-related upstream mechanisms of brain A beta production and deposition. We argue that plasma BACE1 should be considered in further biomarker validation and qualification studies as well as in BACE1 clinical trials. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.

Published
2019
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135. Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (Nature Communications, (2018), 9, 1, (2098), 10.1038/s41467-018-04362-x)

Author

Davies, G. Lam, M. Harris, S.E. Trampush, J.W. Luciano, M. Hill, W.D. Hagenaars, S.P. Ritchie, S.J. Marioni, R.E. Fawns-Ritchie, C. Liewald, D.C.M. Okely, J.A. Ahola-Olli, A.V. Barnes, C.L.K. Bertram, L. Bis, J.C. Burdick, K.E. Christoforou, A. DeRosse, P. Djurovic, S. Espeseth, T. Giakoumaki, S. Giddaluru, S. Gustavson, D.E. Hayward, C. Hofer, E. Ikram, M.A. Karlsson, R. Knowles, E. Lahti, J. Leber, M. Li, S. Mather, K.A. Melle, I. Morris, D. Oldmeadow, C. Palviainen, T. Payton, A. Pazoki, R. Petrovic, K. Reynolds, C.A. Sargurupremraj, M. Scholz, M. Smith, J.A. Smith, A.V. Terzikhan, N. Thalamuthu, A. Trompet, S. van der Lee, S.J. Ware, E.B. Windham, B.G. Wright, M.J. Yang, J. Yu, J. Ames, D. Amin, N. Amouyel, P. Andreassen, O.A. Armstrong, N.J. Assareh, A.A. Attia, J.R. Attix, D. Avramopoulos, D. Bennett, D.A. Böhmer, A.C. Boyle, P.A. Brodaty, H. Campbell, H. Cannon, T.D. Cirulli, E.T. Congdon, E. Conley, E.D. Corley, J. Cox, S.R. Dale, A.M. Dehghan, A. Dick, D. Dickinson, D. Eriksson, J.G. Evangelou, E. Faul, J.D. Ford, I. Freimer, N.A. Gao, H. Giegling, I. Gillespie, N.A. Gordon, S.D. Gottesman, R.F. Griswold, M.E. Gudnason, V. Harris, T.B. Hartmann, A.M. Hatzimanolis, A. Heiss, G. Holliday, E.G. Joshi, P.K. Kähönen, M. Kardia, S.L.R. Karlsson, I. Kleineidam, L. Knopman, D.S. Kochan, N.A. Konte, B. Kwok, J.B. Le Hellard, S. Lee, T. Lehtimäki, T. Li, S.-C. Lill, C.M. Liu, T. Koini, M. London, E. Longstreth, W.T., Jr. Lopez, O.L. Loukola, A. Luck, T. Lundervold, A.J. Lundquist, A. Lyytikäinen, L.-P. Martin, N.G. Montgomery, G.W. Murray, A.D. Need, A.C. Noordam, R. Nyberg, L. Ollier, W. Papenberg, G. Pattie, A. Polasek, O. Poldrack, R.A. Psaty, B.M. Reppermund, S. Riedel-Heller, S.G. Rose, R.J. Rotter, J.I. Roussos, P. Rovio, S.P. Saba, Y. Sabb, F.W. Sachdev, P.S. Satizabal, C.L. Schmid, M. Scott, R.J. Scult, M.A. Simino, J. Slagboom, P.E. Smyrnis, N. Soumaré, A. Stefanis, N.C. Stott, D.J. Straub, R.E. Sundet, K. Taylor, A.M. Taylor, K.D. Tzoulaki, I. Tzourio, C. Uitterlinden, A. Vitart, V. Voineskos, A.N. Kaprio, J. Wagner, M. Wagner, H. Weinhold, L. Wen, K.H. Widen, E. Yang, Q. Zhao, W. Adams, H.H.H. Arking, D.E. Bilder, R.M. Bitsios, P. Boerwinkle, E. Chiba-Falek, O. Corvin, A. De Jager, P.L. Debette, S. Donohoe, G. Elliott, P. Fitzpatrick, A.L. Gill, M. Glahn, D.C. Hägg, S. Hansell, N.K. Hariri, A.R. Ikram, M.K. Jukema, J.W. Vuoksimaa, E. Keller, M.C. Kremen, W.S. Launer, L. Lindenberger, U. Palotie, A. Pedersen, N.L. Pendleton, N. Porteous, D.J. Räikkönen, K. Raitakari, O.T. Ramirez, A. Reinvang, I. Rudan, I. Dan Rujescu Schmidt, R. Schmidt, H. Schofield, P.W. Schofield, P.R. Starr, J.M. Steen, V.M. Trollor, J.N. Turner, S.T. Van Duijn, C.M. Villringer, A. Weinberger, D.R. Weir, D.R. Wilson, J.F. Malhotra, A. McIntosh, A.M. Gale, C.R. Seshadri, S. Mosley, T.H., Jr. Bressler, J. Lencz, T. Deary, I.J.

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article. © 2019, The Author(s).

Published
2019

137. The association between selenium status and cognitive decline in very old adults: The Newcastle 85+ Study.

Author

Perri, G., Mathers, J. C, Martin-Ruiz, C., Parker, C., Demircan, K., Chillon, T. S., Schomburg, L., Robinson, L., Stevenson, E. J, Terrera, G., Sniehotta, F. F, Ritchie, C., Adamson, A., Burns, A., Minihane, A.M, Shannon, O., and Hill, T.R

Abstract

The trace element selenium is known to protect against oxidative damage which is known to contribute to cognitive impairment with ageing (1 , 2). The aim of this study was to explore the association between selenium status (serum selenium and selenoprotein P (SELENOP)) and global cognitive performance at baseline and after 5 years in 85-year-olds living in the Northeast of England. Serum selenium and SELENOP concentrations were measured at baseline by total reflection X-ray fluorescence (TXRF) and enzyme-linked immunosorbent assay (ELISA), respectively, in 757 participants from the Newcastle 85+ study. Global cognitive performance was assessed using the Standardized Mini-Mental State Examination (SMMSE) where scores ≤25 out of 30 indicated cognitive impairment. Logistic regressions explored the associations between selenium status and global cognition at baseline. Linear mixed models explored associations between selenium status and global cognition prospectively after 5 years. Covariates included sex, body mass index, physical activity, high sensitivity C-reactive protein, alcohol intake, self-rated health, medications and smoking status. At baseline, in fully adjusted models, there was no increase in odds of cognitive impairment with serum selenium (OR 1.004, 95% CI 0.993-1.015, p = 0.512) or between SELENOP (OR 1.006, 95% CI 0.881-1.149, p = 0.930). Likewise, over 5 years, in fully adjusted models there was no association between serum selenium and cognitive impairment (β 7.20E-4 ± 5.57E-4, p = 0.197), or between SELENOP and cognitive impairment (β 3.50E-3 ± 6.85E-3, p = 0.610). In this UK cohort of very old adults, serum selenium or SELENOP was not associated with cognitive impairment at baseline and 5 years. This was an unexpected finding despite SELENOP's key role in the brain and the observed associations in other studies. Further research is needed to explore the effect of selenium on global cognition in very old adults. [ABSTRACT FROM AUTHOR]

Published
2024
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138. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author

Davies, G, Lam, M, Harris, SE, Trampush, JW, Luciano, M, Hill, WD, Hagenaars, SP, Ritchie, SJ, Marioni, RE, Fawns-Ritchie, C, Liewald, DCM, Okely, JA, Ahola-Olli, AV, Barnes, CLK, Bertram, L, Bis, JC, Burdick, KE, Christoforou, A, Derosse, P, Djurovic, S, Espeseth, T, Giakoumaki, S, Giddaluru, S, Gustavson, DE, Hayward, C, Hofer, E, Ikram, MA, Karlsson, R, Knowles, E, Lahti, J, Leber, M, Li, S, Mather, KA, Melle, I, Morris, D, Oldmeadow, C, Palviainen, T, Payton, A, Pazoki, R, Petrovic, K, Reynolds, CA, Sargurupremraj, M, Scholz, M, Smith, JA, Smith, AV, Terzikhan, N, Thalamuthu, A, Trompet, S, Van Der Lee, SJ, Ware, EB, Windham, BG, Wright, MJ, Yang, J, Yu, J, Ames, D, Amin, N, Amouyel, P, Andreassen, OA, Armstrong, NJ, Assareh, AA, Attia, JR, Attix, D, Avramopoulos, D, Bennett, DA, Böhmer, AC, Boyle, PA, and Brodaty, H

Abstract

© 2018 The Author(s). General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.

Published
2018
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141. Basal Forebrain Volume, but Not Hippocampal Volume, Is a Predictor of Global Cognitive Decline in Patients With Alzheimer's Disease Treated With Cholinesterase Inhibitors

Author

Teipel, Sj, Cavedo, E, Hampel, H, Grothe, Mj, Aguilar, Lf, Babiloni, C, Baldacci, F, Benda, N, Black, Kl, Bokde, Alw, Bonuccelli, U, Broich, K, Bun, Rs, Cacciola, F, Castrillo, J, Ceravolo, R, Chiesa, Pa, Colliot, O, Coman, C, Corvol, J, Cuello, Ac, Depypere, H, Dubois, B, Duggento, A, Durrleman, S, Escott-Price, V, Federoff, H, Ferretti, Mt, Fiandaca, M, Frank, Ra, Garaci, F, Genthon, R, George, N, Giorgi, Fs, Graziani, M, Haberkamp, M, Habert, M, Herholz, K, Karran, E, Kim, Sh, Koronyo, Y, Koronyo-Hamaoui, M, Lamari, F, Langevin, T, Lehericy, S, Lista, S, Lorenceau, J, Mapstone, M, Neri, C, Nistico, R, Nyasse-Messene, F, O'Bryant, Se, Perry, G, Ritchie, C, Rojkova, K, Rossi, S, Saidi, A, Santarnecchi, E, Schneider, Ls, Sporns, O, Toschi, N, Verdooner, Sr, Vergallo, A, Villain, N, Welikovitch, La, Woodcock, J, Younesi, E, and Cummings, Jl

Subjects
Aging, hippocampus, Hippocampus, Neurodegenerative, Alzheimer's Disease, lcsh:RC346-429, cholinergic treatment, memory, 0302 clinical medicine, Medicine and Health Sciences, Psychology, Medicine, Cognitive decline, Episodic memory, basal forebrain, Original Research, Basal forebrain, Settore FIS/07, 05 social sciences, Cognition, IMPAIRMENT, Manchester Institute for Collaborative Research on Ageing, Neurology, Neurological, Cohort, DONEPEZIL, Cardiology, NUCLEUS BASALIS, ADAS-COG, MRI, CHOLINERGIC SYSTEM, medicine.medical_specialty, ResearchInstitutes_Networks_Beacons/MICRA, Clinical Sciences, COMPOSITE SCORE, ATROPHY, 050105 experimental psychology, 03 medical and health sciences, Clinical Research, Internal medicine, Behavioral and Social Science, Acquired Cognitive Impairment, Dementia, 0501 psychology and cognitive sciences, ddc:610, lcsh:Neurology. Diseases of the nervous system, business.industry, Alzheimer's Disease Neuroimaging Initiative, Neurosciences, Alzheimer Precision Medicine Initiative, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), prediction, medicine.disease, NEUROIMAGING INITIATIVE ADNI, Brain Disorders, SUBSTANTIA INNOMINATA, executive function, Cholinergic treatment, Executive function, Memory, Prediction, Cholinergic, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Background: Predicting the progression of cognitive decline in Alzheimer's disease (AD) is important for treatment selection and patient counseling. Structural MRI markers such as hippocampus or basal forebrain volumes might represent useful instruments for the prediction of cognitive decline. The primary objective was to determine the predictive value of hippocampus and basal forebrain volumes for global and domain specific cognitive decline in AD dementia during cholinergic treatment.Methods: We used MRI and cognitive data from 124 patients with the clinical diagnosis of AD dementia, derived from the ADNI-1 cohort, who were on standard of care cholinesterase inhibitor treatment during a follow-up period between 0.4 and 3.1 years. We used linear mixed effects models with cognitive function as outcome to assess the main effects as well as two-way interactions between baseline volumes and time controlling for age, sex, and total intracranial volume. This model accounts for individual variation in follow-up times.Results: Basal forebrain volume, but not hippocampus volume, was a significant predictor of rates of global cognitive decline. Larger volumes were associated with smaller rates of cognitive decline. Left hippocampus volume had a modest association with rates of episodic memory decline. Baseline performance in global cognition and memory was significantly associated with hippocampus and basal forebrain volumes; in addition, basal forebrain volume was associated with baseline performance in executive function.Conclusions: Our findings indicate that in AD dementia patients, basal forebrain volume may be a useful marker to predict subsequent cognitive decline during cholinergic treatment.

Published
2018
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142. Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

Author

Hagenaars, Sp, Radaković, R, Crockford, C, Fawns-Ritchie, C, Gale, Cr, Deary, Ij, J B, J Kwok, Dobson-Stone, C, R Schofield, P, Gmhalliday, R Hodges, J, Piguet, O, Bartley, L, Thompson, E, Hernaândez, I, Ruiz, A, Mboada, Borroni, B, Padovani, A, Cruchaga, C, J Cairns, N, Benussi, L, Binetti, G, Ghidoni, R, Forloni, G, Albani, D, Galimberti, D, Fenoglio, C, Serpente, M, Scarpini, E, Clarimoân, J, Lleoâ, A, Blesa, R, Mlandqvist, Waldoè, Nilsson, K, Nilsson, C, I R, A Mackenzie, G-Y, R Hsiung, Dma, Mann, Grafman, J, Cmmorris, Attems, J, D Griffiths, T, G McKeith, I, J Thomas, A, Pietrini, P, D Huey, E, Emwassermann, Baborie, A, Jaros, E, Tierney, Mc, Pastor, P, Razquin, C, Ortega-Cubero, S, Alonso, E, Perneczky, R, Diehl-Schmid, J, Alexopoulos, P, Kurz, A, Rainero, I, Rubino, E, Pinessi, L, Rogaeva, E, P St George-Hyslop, Rossi, G, Tagliavini, F, Giaccone, G, B Rowe, J, Cmschlachetzki, J, Uphill, J, Collinge, J, Mead, S, Danek, A, Vmvan, Deerlin, Mgrossman, Q Trojanowski, J, J van der Zee, C Van Broeckhoven, F Cappa, S, Leber, I, Hannequin, D, Golfier, V, Mvercelletto, Brice, A, Nacmias, B, Sorbi, S, Bagnoli, S, Piaceri, I, E Nielsen, J, E Hjermind, L, Mriemenschneider, Mmayhaus, Ibach, B, Gasparoni, G, Pichler, S, Wgu, Rossor, Mn, C Fox, N, D Warren, J, Spillantini, Mg, R Morris, H, Rizzu, P, Heutink, P, S Snowden, J, Rollinson, S, Richardson, A, Gerhard, A, C Bruni, A, Maletta, R, Frangipane, F, Cupidi, C, Bernardi, L, Manfossi, Mgallo, Conidi, Me, Smirne, N, Rademakers, R, Baker, M, Dwdickson, R Graff-Radford, N, C Petersen, R, Knopman, D, A Josephs, K, F Boeve, B, E Parisi, J, Wwseeley, L Miller, B, Amkarydas, Rosen, H, C van Swieten, J, E G, P Dopper, Seelaar, H, Y A, L Pijnenburg, Scheltens, P, Logroscino, G, Capozzo, R, Novelli, V, A Puca, A, Franceschi, M, Postiglione, A, Milan, G, Sorrentino, P, Mkristiansen, H-H, Chiang, Graff, C, Pasquier, F, Rollin, A, Deramecourt, V, Lebouvier, T, Kapogiannis, D, Ferrucci, L, Pickering-Brown, S, B Singleton, A, Hardy, J, and Momeni., P

Subjects
Genetics and Molecular Biology (all), Multifactorial Inheritance, Peak Expiratory Flow Rate, Disease, Physical function, Alzheimer's Disease, Biochemistry, Motor Neuron Diseases, 0302 clinical medicine, Cognition, Learning and Memory, Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), Forced Expiratory Volume, Medicine and Health Sciences, Amyotrophic lateral sclerosis, Genetic risk, Cognitive Impairment, 0303 health sciences, Cognitive Neurology, Neurodegenerative Diseases, Middle Aged, Mental Status and Dementia Tests, Neurology, Frontotemporal Dementia, Clinical psychology, Frontotemporal dementia, Research Article, Adult, Cognitive Neuroscience, Risk Assessment, 03 medical and health sciences, Memory, Alzheimer Disease, Mental Health and Psychiatry, mental disorders, medicine, Genetics, Humans, Effects of sleep deprivation on cognitive performance, Muscle Strength, Genetic Association Studies, 030304 developmental biology, Aged, business.industry, Amyotrophic Lateral Sclerosis, Biology and Life Sciences, medicine.disease, United Kingdom, Physical Fitness, Genetics of Disease, Cognitive Science, Polygenic risk score, Dementia, business, 030217 neurology & neurosurgery, Neuroscience, Genome-Wide Association Study
Abstract

INTRODUCTIONIt is unclear whether polygenic risk for neurodegenerative disease is associated with cognitive performance and physical health.METHODSThis study tested whether polygenic scores for Alzheimer’s disease (AD), Amyotrophic Lateral Sclerosis (ALS), or frontotemporal dementia (FTD) are associated with cognitive performance and physical health. Group-based analyses were performed to compare associations with cognitive and physical function outcomes in the top and bottom 10% for the three neurodegenerative polygenic risk scores.RESULTSHigher polygenic risk scores for AD, ALS, and FTD were associated with lower cognitive performance. Higher polygenic risk scores for FTD was also associated with increased forced expiratory volume in 1s and peak expiratory flow. A significant group difference was observed on the symbol digit substitution task between individuals with high polygenic risk for FTD and high polygenic risk for ALS.DISCUSSIONOur results suggest overlap between polygenic risk for neurodegenerative disorders, cognitive function and physical health.

Published
2018

144. The Dementias Platform UK (DPUK) Data Portal

Author

Bauermeister, S, primary, Orton, C, additional, Thompson, S, additional, Barker, R A, additional, Bauermeister, J R, additional, Ben-Shlomo, Y, additional, Brayne, C, additional, Burn, D, additional, Campbell, A, additional, Calvin, C, additional, Chandran, S, additional, Chaturvedi, N, additional, Chene, G, additional, Chessell, I P, additional, Corbett, A, additional, Davis, D H J, additional, Denis, M, additional, Dufouil, C, additional, Elliott, P, additional, Fox, N, additional, Hill, D, additional, Hofer, SM, additional, Hu, M T, additional, Jindra, C, additional, Kee, F, additional, Kim, C H, additional, Kim, C, additional, Kivimaki, M, additional, Koychev, I, additional, Lawson, R A, additional, Linden, G J, additional, Lyons, R A, additional, Mackay, C, additional, Matthews, P M, additional, McGuiness, B, additional, Middleton, L, additional, Moody, C, additional, Moore, K, additional, Na, D L, additional, O’Brien, J T, additional, Ourselin, S, additional, Paranjothy, S, additional, Park, K S, additional, Porteous, D J, additional, Richards, M, additional, Ritchie, C W, additional, Rohrer, J D, additional, Rossor, M N, additional, Rowe, J B, additional, Scahill, R, additional, Schnier, C, additional, Schott, J M, additional, Seo, S W, additional, South, M, additional, Steptoe, A, additional, Tabrizi, S J, additional, Tales, A, additional, Tillin, T, additional, Timpson, N J, additional, Toga, A W, additional, Visser, PJ, additional, Wade-Martins, R, additional, Wilkinson, T, additional, Williams, J, additional, Wong, A, additional, and Gallacher, J E, additional

Published
2019
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145. 03:18 PM Abstract No. 114 A single-center experience with proximal radioembolization enabled by distal angiosomal truncation (PREDATr)

Author

Core, J., primary, Pham, T., additional, Bailey, R., additional, Vidal, L., additional, Bussone, S., additional, Sturchio, G., additional, LeGout, J., additional, Sharma, A., additional, Jain, M., additional, McKinney, J., additional, Ritchie, C., additional, Paz-Fumagalli, R., additional, Lewis, A., additional, Frey, G., additional, and Toskich, B., additional

Published
2019
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146. 03:09 PM Abstract No. 113 Lobar Yttrium-90 transarterial radioembolization equal or greater than 150Gy MIRD: an analysis of hepatic biochemical safety as a function of treated liver volume and administered dose

Author

Ahmed, A., primary, Paz-Fumagalli, R., additional, McKinney, J., additional, Ritchie, C., additional, Frey, G., additional, Lewis, A., additional, Devcic, Z., additional, Livingston, D., additional, Cheiky, E., additional, Vega, L., additional, Hodge, D., additional, Vidal, L., additional, Shah, J., additional, Geller, B., additional, Kolarich, A., additional, Wang, M., additional, Alvarado, C., additional, Iv, C., additional, Lubinski, A., additional, and Toskich, B., additional

Published
2019
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149. Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (Nature Communications, (2018), 9, 1, (2098), 10.1038/s41467-018-04362-x)

Author

Davies, G. Lam, M. Harris, S.E. Trampush, J.W. Luciano, M. Hill, W.D. Hagenaars, S.P. Ritchie, S.J. Marioni, R.E. Fawns-Ritchie, C. Liewald, D.C.M. Okely, J.A. Ahola-Olli, A.V. Barnes, C.L.K. Bertram, L. Bis, J.C. Burdick, K.E. Christoforou, A. DeRosse, P. Djurovic, S. Espeseth, T. Giakoumaki, S. Giddaluru, S. Gustavson, D.E. Hayward, C. Hofer, E. Ikram, M.A. Karlsson, R. Knowles, E. Lahti, J. Leber, M. Li, S. Mather, K.A. Melle, I. Morris, D. Oldmeadow, C. Palviainen, T. Payton, A. Pazoki, R. Petrovic, K. Reynolds, C.A. Sargurupremraj, M. Scholz, M. Smith, J.A. Smith, A.V. Terzikhan, N. Thalamuthu, A. Trompet, S. van der Lee, S.J. Ware, E.B. Windham, B.G. Wright, M.J. Yang, J. Yu, J. Ames, D. Amin, N. Amouyel, P. Andreassen, O.A. Armstrong, N.J. Assareh, A.A. Attia, J.R. Attix, D. Avramopoulos, D. Bennett, D.A. Böhmer, A.C. Boyle, P.A. Brodaty, H. Campbell, H. Cannon, T.D. Cirulli, E.T. Congdon, E. Conley, E.D. Corley, J. Cox, S.R. Dale, A.M. Dehghan, A. Dick, D. Dickinson, D. Eriksson, J.G. Evangelou, E. Faul, J.D. Ford, I. Freimer, N.A. Gao, H. Giegling, I. Gillespie, N.A. Gordon, S.D. Gottesman, R.F. Griswold, M.E. Gudnason, V. Harris, T.B. Hartmann, A.M. Hatzimanolis, A. Heiss, G. Holliday, E.G. Joshi, P.K. Kähönen, M. Kardia, S.L.R. Karlsson, I. Kleineidam, L. Knopman, D.S. Kochan, N.A. Konte, B. Kwok, J.B. Le Hellard, S. Lee, T. Lehtimäki, T. Li, S.-C. Lill, C.M. Liu, T. Koini, M. London, E. Longstreth, W.T., Jr. Lopez, O.L. Loukola, A. Luck, T. Lundervold, A.J. Lundquist, A. Lyytikäinen, L.-P. Martin, N.G. Montgomery, G.W. Murray, A.D. Need, A.C. Noordam, R. Nyberg, L. Ollier, W. Papenberg, G. Pattie, A. Polasek, O. Poldrack, R.A. Psaty, B.M. Reppermund, S. Riedel-Heller, S.G. Rose, R.J. Rotter, J.I. Roussos, P. Rovio, S.P. Saba, Y. Sabb, F.W. Sachdev, P.S. Satizabal, C.L. Schmid, M. Scott, R.J. Scult, M.A. Simino, J. Slagboom, P.E. Smyrnis, N. Soumaré, A. Stefanis, N.C. Stott, D.J. Straub, R.E. Sundet, K. Taylor, A.M. Taylor, K.D. Tzoulaki, I. Tzourio, C. U and Davies, G. Lam, M. Harris, S.E. Trampush, J.W. Luciano, M. Hill, W.D. Hagenaars, S.P. Ritchie, S.J. Marioni, R.E. Fawns-Ritchie, C. Liewald, D.C.M. Okely, J.A. Ahola-Olli, A.V. Barnes, C.L.K. Bertram, L. Bis, J.C. Burdick, K.E. Christoforou, A. DeRosse, P. Djurovic, S. Espeseth, T. Giakoumaki, S. Giddaluru, S. Gustavson, D.E. Hayward, C. Hofer, E. Ikram, M.A. Karlsson, R. Knowles, E. Lahti, J. Leber, M. Li, S. Mather, K.A. Melle, I. Morris, D. Oldmeadow, C. Palviainen, T. Payton, A. Pazoki, R. Petrovic, K. Reynolds, C.A. Sargurupremraj, M. Scholz, M. Smith, J.A. Smith, A.V. Terzikhan, N. Thalamuthu, A. Trompet, S. van der Lee, S.J. Ware, E.B. Windham, B.G. Wright, M.J. Yang, J. Yu, J. Ames, D. Amin, N. Amouyel, P. Andreassen, O.A. Armstrong, N.J. Assareh, A.A. Attia, J.R. Attix, D. Avramopoulos, D. Bennett, D.A. Böhmer, A.C. Boyle, P.A. Brodaty, H. Campbell, H. Cannon, T.D. Cirulli, E.T. Congdon, E. Conley, E.D. Corley, J. Cox, S.R. Dale, A.M. Dehghan, A. Dick, D. Dickinson, D. Eriksson, J.G. Evangelou, E. Faul, J.D. Ford, I. Freimer, N.A. Gao, H. Giegling, I. Gillespie, N.A. Gordon, S.D. Gottesman, R.F. Griswold, M.E. Gudnason, V. Harris, T.B. Hartmann, A.M. Hatzimanolis, A. Heiss, G. Holliday, E.G. Joshi, P.K. Kähönen, M. Kardia, S.L.R. Karlsson, I. Kleineidam, L. Knopman, D.S. Kochan, N.A. Konte, B. Kwok, J.B. Le Hellard, S. Lee, T. Lehtimäki, T. Li, S.-C. Lill, C.M. Liu, T. Koini, M. London, E. Longstreth, W.T., Jr. Lopez, O.L. Loukola, A. Luck, T. Lundervold, A.J. Lundquist, A. Lyytikäinen, L.-P. Martin, N.G. Montgomery, G.W. Murray, A.D. Need, A.C. Noordam, R. Nyberg, L. Ollier, W. Papenberg, G. Pattie, A. Polasek, O. Poldrack, R.A. Psaty, B.M. Reppermund, S. Riedel-Heller, S.G. Rose, R.J. Rotter, J.I. Roussos, P. Rovio, S.P. Saba, Y. Sabb, F.W. Sachdev, P.S. Satizabal, C.L. Schmid, M. Scott, R.J. Scult, M.A. Simino, J. Slagboom, P.E. Smyrnis, N. Soumaré, A. Stefanis, N.C. Stott, D.J. Straub, R.E. Sundet, K. Taylor, A.M. Taylor, K.D. Tzoulaki, I. Tzourio, C. U

Abstract

Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article. © 2019, The Author(s).

Published
2019

150. Aqueous Synthesis of Cu2ZnSnSe4 Nanocrystals

Author

Ritchie, C, Chesman, ASR, Jasieniak, J, Mulvaney, P, Ritchie, C, Chesman, ASR, Jasieniak, J, and Mulvaney, P

Abstract

Copper zinc tin selenide (CZTSe) nanocrystal inks show promise as a candidate for developing cheap, scalable, efficient, and nontoxic photovoltaic devices. They also present an important opportunity to controllably mix copper zinc tin sulfide (CZTS) with CZTSe to produce directly spectrally tunable Cu 2 ZnSn(S/Se) 4 (CZTSSe) solid-solutions using low-temperature processes. Herein, we describe a one-pot, low-temperature, aqueous-based synthesis that employs simultaneous redox and crystal formation reactions to yield CZTSe nanocrystal inks stabilized by Sn 2 Se 76- and thiourea. This versatile CZTSe synthesis is understood through the use of inductively coupled plasma mass spectrometry, Raman spectroscopy, Fourier transform infrared spectroscopy, and powder X-ray diffraction. It is further shown that stoichiometrically mixed CZTSe and CZTS nanocrystal powders yield a single CZTSSe phase at annealing temperatures between 200 and 250 °C. This facile and low-temperature process offers a low-energy alternative for the deposition of pure CZTSe/SSe thin films and enables the band gap to be readily tuned from 1.5 down to 1.0 eV by simple solution chemistry.

Published
2019

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