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101. Persistence of seroconversion at 6 months following primary immunisation in patients with immune-mediated inflammatory diseases

Author

Wieske, Luuk, primary, Stalman, Eileen W, additional, van Dam, P J Koos, additional, Kummer, Laura Y, additional, Steenhuis, Maurice, additional, van Kempen, Zoe L E, additional, Killestein, Joep, additional, Volkers, Adriaan G, additional, Tas, Sander W, additional, Boekel, Laura, additional, Wolbink, Gertjan, additional, Van der Kooi, Anneke, additional, Raaphorst, Joost, additional, Löwenberg, Mark, additional, Takkenberg, Bart, additional, D’Haens, Geert R A M, additional, Spuls, Phyllis I, additional, Bekkenk, Marcel W, additional, Musters, Annelie H, additional, Post, Nicoline F, additional, Bosma, Angela L, additional, Hilhorst, Marc L, additional, Vegting, Yosta, additional, Bemelman, Frederique J, additional, Voskuyl, Alexandre, additional, Broens, Bo, additional, Parra Sanchez, Agner, additional, van Els, Cécile A C M, additional, Wit, Jelle De, additional, Rutgers, Abraham, additional, de Leeuw, Karina, additional, Horváth, Barbara, additional, Verschuuren, Jan J G M, additional, Ruiter, Annabel M, additional, van Ouwerkerk, Lotte, additional, van der Woude, Diane, additional, Allaart, Cornelia F, additional, Teng, Y K Onno, additional, van Paassen, Pieter, additional, Busch, Matthias H, additional, Jallah, Papay B P, additional, Brusse, Esther, additional, van Doorn, Pieter A, additional, Baars, Adája Elisabeth, additional, Hijnen, Dirkjan, additional, Schreurs, Corine R G, additional, Van der Pol, W Ludo, additional, Goedee, H Stephan, additional, Keijzer, Sofie, additional, Keijser, Jim, additional, Cristianawati, Olvi, additional, ten Brinke, Anja, additional, Verstegen, Niels J M, additional, Zwinderman, Koos A H, additional, van Ham, S Marieke, additional, Kuijpers, Taco W, additional, Rispens, Theo, additional, and Eftimov, Filip, additional

Published
2023
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102. Factors affecting IgG4-mediated complement activation

Author

Oskam, Nienke, primary, Damelang, Timon, additional, Streutker, Marij, additional, Ooijevaar-de Heer, Pleuni, additional, Nouta, Jan, additional, Koeleman, Carolien, additional, Van Coillie, Julie, additional, Wuhrer, Manfred, additional, Vidarsson, Gestur, additional, and Rispens, Theo, additional

Published
2023
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103. Ocrelizumab concentration and antidrug antibodies are associated with B-cell count in multiple sclerosis

Author

Toorop, Alyssa A, primary, Hogenboom, Laura, additional, Bloem, Karien, additional, Kocyigit, Merve, additional, Commandeur, Nadine W M, additional, Wijnants, Anne, additional, Lissenberg-Witte, Birgit I, additional, Strijbis, Eva M M, additional, Uitdehaag, Bernard M J, additional, Rispens, Theo, additional, Killestein, Joep, additional, and van Kempen, Zoé L E, additional

Published
2023
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104. Decrease of natalizumab drug levels after switching from intravenous to subcutaneous administration in patients with multiple sclerosis

Author

Toorop, Alyssa A, primary, van Kempen, Zoé L E, additional, Steenhuis, Maurice, additional, Nielsen, Jessica, additional, Sinnige, L G F, additional, van Dijk, Gert, additional, Roosendaal, Christiaan M, additional, Arnoldus, Edo P J, additional, Hoitsma, Elske, additional, Lissenberg-Witte, Birgit I, additional, de Jong, Brigit A, additional, Oosten, Bob W van, additional, Strijbis, Eva M M, additional, Uitdehaag, Bernard M J, additional, Rispens, Theo, additional, and Killestein, Joep, additional

Published
2023
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105. Primary SARS-CoV-2 infection in patients with immune-mediated inflammatory diseases: long-term humoral immune responses and effects on disease activity

Author

Dam, Koos van, primary, Volkers, Adriaan, additional, Wieske, Luuk, additional, Stalman, Eileen, additional, Kummer, Laura, additional, kempen, Zoe van, additional, Killestein, Joep, additional, Tas, Sander, additional, Boekel, Laura, additional, Wolbink, Gertjan, additional, Kooi, Anneke van der, additional, Raaphorst, Joost, additional, Takkenberg, Bart, additional, D'Haens, Geert, additional, Spuls, Phyllis, additional, Bekkenk, Marcel, additional, Musters, Annelie, additional, Post, Nicoline, additional, Bosma, Angela, additional, Hilhorst, Marc, additional, Vegting, Yosta, additional, Bemelman, Frederike, additional, Voskuyl, Alexandre, additional, Broens, Bo, additional, Sanchez, Agner Parra, additional, Els, Cecile van, additional, de Wit, Jelle, additional, Rutgers, Abraham, additional, de Leeuw, Karina, additional, Horvath, Barbara, additional, Verschuuren, Jan, additional, Ruiter, Annabel, additional, Ouwerkerk, Lotte van, additional, Woude, Diane van der, additional, Allaart, Renee, additional, Teng, Onno, additional, Paassen, Pieter van, additional, Busch, Matthias, additional, Jallah, Papay, additional, Brusse, Esther, additional, Doorn, Pieter van, additional, Baars, Adaja, additional, Hijnen, DirkJan, additional, Schreurs, Corine, additional, Pol, Ludo van der, additional, Goedee, Stephan, additional, Steenhuis, Maurice, additional, Keijzer, Sofie, additional, Keijser, Jim, additional, Cristianawati, Olvi, additional, Brinke, Anja ten, additional, Verstegen, Niels, additional, Ham, Marieke van, additional, Rispens, Theo, additional, Kuijpers, Taco, additional, Lowenberg, Mark, additional, and Eftimov, Filip, additional

Published
2023
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106. Ferric carboxymaltose and SARS-CoV-2 vaccination-induced immunogenicity in kidney transplant recipients with iron deficiency: The COVAC-EFFECT randomized controlled trial

Author

Vinke, Joanna Sophia J., primary, Altulea, Dania H. A., additional, Eisenga, Michele F., additional, Jagersma, Renate L., additional, Niekolaas, Tessa M., additional, van Baarle, Debbie, additional, Heiden, Marieke van Der, additional, Steenhuis, Maurice, additional, Rispens, Theo, additional, Abdulahad, Wayel H., additional, Sanders, Jan-Stephan F., additional, and De Borst, Martin H., additional

Published
2023
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107. Longitudinal Dynamics of the SARS-CoV-2 Antibody Repertoire after SARS-CoV-2 Delta and Omicron Breakthrough Infections in Patients with Immune-Mediated Inflammatory Diseases

Author

Stalman, Eileen, primary, Wieske, Luuk, additional, Keijser, Jim, additional, van Dam, Koos, additional, Kummer, Laura, additional, Wilbrink, Maarten F., additional, van Kempen, Zoé, additional, Killestein, Joep, additional, Volkers, Adriaan G., additional, Tas, Sander, additional, Boekel, Laura, additional, Wolbink, Gertjan, additional, van der Kooi, Anneke J., additional, Raaphorst, Joost, additional, Löwenberg, Mark, additional, Takkenberg, R. Bart, additional, D'Haens, Geert R.A.M., additional, Spuls, Phyllis I., additional, Bekkenk, Marcel W., additional, Musters, Annelie H., additional, Post, Nicoline F., additional, Bosma, Angela L., additional, Hilhorst, Marc L., additional, Vegting, Yosta, additional, Bemelman, Frederike J., additional, Voskuyl, Alexandre, additional, Broens, Bo, additional, Sanchez, Agner Parra, additional, van Els, Cecile, additional, de Wit, Jelle, additional, Rutgers, Abraham, additional, de Leeuw, Karina, additional, Horváth, Barbara, additional, Verschuuren, Jan J.G.M., additional, Ruiter, Annabel M., additional, van Ouwerkerk, Lotte, additional, van der Woude, Diane, additional, Allaart, Cornelia F., additional, Teng, Onno YK, additional, van Paassen, Pieter, additional, Busch, Matthias, additional, Brusse, Esther, additional, van Doorn, Pieter, additional, Baars, Adája E., additional, Hijnen, Dirk Jan, additional, Schreurs, Corine R.G., additional, van der Pol, Ludo, additional, Goedee, H. Stephan, additional, Steenhuis, Maurice, additional, Keijzer, Sofie, additional, Cristianawati, Olvi, additional, ten Brinke, Anja, additional, Verstegen, Niels, additional, Zwinderman, Aeilko H., additional, van Ham, Marieke, additional, Rispens, Theo, additional, Welkers, Matthijs R.A., additional, Jonges, Marcel, additional, Eftimov, Filip, additional, and Kuijpers, Taco, additional

Published
2023
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108. The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation

Author

de Boer, Esther CW, primary, Thielen, Astrid JF, additional, Langereis, Jeroen D, additional, Kamp, Angela, additional, Brouwer, Mieke C, additional, Oskam, Nienke, additional, Jongsma, Marlieke L, additional, Baral, April J, additional, Spaapen, Robbert M, additional, Zeerleder, Sacha, additional, Vidarsson, Gestur, additional, Rispens, Theo, additional, Wouters, Diana, additional, Pouw, Richard B, additional, and Jongerius, Ilse, additional

Published
2023
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109. The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees

Author

Van Coillie, Julie, primary, Pongracz, Tamas, additional, Rahmöller, Johann, additional, Chen, Hung-Jen, additional, Geyer, Chiara Elisabeth, additional, van Vught, Lonneke A., additional, Buhre, Jana Sophia, additional, Šuštić, Tonći, additional, van Osch, Thijs Luc Junior, additional, Steenhuis, Maurice, additional, Hoepel, Willianne, additional, Wang, Wenjun, additional, Lixenfeld, Anne Sophie, additional, Nouta, Jan, additional, Keijzer, Sofie, additional, Linty, Federica, additional, Visser, Remco, additional, Larsen, Mads Delbo, additional, Martin, Emily Lara, additional, Künsting, Inga, additional, Lehrian, Selina, additional, von Kopylow, Vera, additional, Kern, Carsten, additional, Lunding, Hanna Bele, additional, de Winther, Menno, additional, van Mourik, Niels, additional, Rispens, Theo, additional, Graf, Tobias, additional, Slim, Marleen Adriana, additional, Minnaar, René Peter, additional, Bomers, Marije Kristianne, additional, Sikkens, Jonne Jochum, additional, Vlaar, Alexander P.J., additional, van der Schoot, C. Ellen, additional, den Dunnen, Jeroen, additional, Wuhrer, Manfred, additional, Ehlers, Marc, additional, Vidarsson, Gestur, additional, Antinori, Spinello, additional, Bassoli, Cinzia, additional, Bestetti, Giovanna, additional, Corbellino, Mario, additional, Covizzi, Alice, additional, Lupo, Angelica, additional, Milazzo, Laura, additional, Schiuma, Marco, additional, Torre, Alessandro, additional, Appelman, Brent, additional, van de Beek, Diederik, additional, Bomers, Marije K., additional, de Brabander, Justin, additional, Brouwer, Matthijs C., additional, Buis, David T.P., additional, Chekrouni, Nora, additional, van Gils, Marit J., additional, de Jong, Menno D., additional, Lavell, Ayesha H.A., additional, Olie, Sabine E., additional, Peters, Edgar J.G., additional, Reijnders, Tom D.Y., additional, Schinkel, Michiel, additional, Schuurman, Alex R., additional, Sikkens, Jonne J., additional, Slim, Marleen A., additional, Smulders, Yvo M., additional, and Wiersinga, Joost W., additional

Published
2023
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110. Anti-rituximab antibodies affect pharmacokinetics and pharmacodynamics of rituximab in children with immune-mediated diseases

Author

Oomen, Ilja, Rashid, Amara Nassar-Sheikh, Bouts, Antonia H. M., Gouw, Samantha C., Kuijpers, Taco W., Rispens, Theo, de Vries, Annick, Wolbink, Gertjan, van den Berg, J. Merlijn, Schonenberg-Meinema, Dieneke, Graduate School, Paediatric Pulmonology, Paediatric Nephrology, Paediatric Haematology, Landsteiner Laboratory, Paediatric Infectious Diseases / Rheumatology / Immunology, AII - Infectious diseases, AII - Inflammatory diseases, ARD - Amsterdam Reproduction and Development, Rheumatology, and Radiation Oncology

Subjects
B-Lymphocytes, congenital, hereditary, and neonatal diseases and abnormalities, Immunology, Antibodies, Monoclonal, nutritional and metabolic diseases, hemic and immune systems, Antigens, CD20, enzymes and coenzymes (carbohydrates), Treatment Outcome, Pharmacodynamics, Rheumatology, immune system diseases, Humans, Immunology and Allergy, Pharmacokinetics, Child, Rituximab, Retrospective Studies
Abstract

Objective Rituximab (RTX) is a chimeric monoclonal CD20-antibody. Lack of efficacy has been suggested to be related to the presence of anti-drug antibodies (ADA). The aims of this study were to determine if ADA impact the pharmacokinetics (PK) and pharmacodynamics (PD) of RTX in children, whether the formation of ADA differs between various immune-mediated diseases and if it is related to the occurrence of infusion-related reactions (IRR). Methods All children 8 AU/ml. Results Of twenty-six children treated with RTX for various immune-mediated diseases, six patients were ADA-positive (23.1%). In all ADA-positive patients, RTX concentrations were undetectable in contrast to ADA-negative patients (median RTX concentration 3.1 μg/ml; IQR 0.57-12.0; p

Published
2022

111. SARS-CoV-2 omicron breakthrough infections in patients with multiple sclerosis

Author

van Kempen, Zoé L E, primary, Stalman, Eileen W, additional, Steenhuis, Maurice, additional, Kummer, Laura Y L, additional, van Dam, Koos P J, additional, Wilbrink, Maarten F, additional, ten Brinke, Anja, additional, van Ham, S Marieke, additional, Kuijpers, Taco, additional, Rispens, Theo, additional, Eftimov, Filip, additional, Wieske, Luuk, additional, and Killestein, Joep, additional

Published
2022
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113. Association of Serum Dupilumab Levels at 16 Weeks With Treatment Response and Adverse Effects in Patients With Atopic Dermatitis

Author

Spekhorst, Lotte S., primary, de Graaf, Marlies, additional, Loeff, Floris, additional, Zuithoff, Nicolaas P. A., additional, Bakker, Daphne, additional, Boesjes, Celeste M., additional, Thijs, Judith, additional, Achten, Roselie, additional, van Wijk, Femke, additional, Rispens, Theo, additional, and de Bruin-Weller, Marjolein S., additional

Published
2022
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114. Additional file 1 of Primary SARS-CoV-2 infection in patients with immune-mediated inflammatory diseases: long-term humoral immune responses and effects on disease activity

Author

van Dam, Koos P. J., Volkers, Adriaan G., Wieske, Luuk, Stalman, Eileen W., Kummer, Laura Y. L., van Kempen, Zoé L. E., Killestein, Joep, Tas, Sander W., Boekel, Laura, Wolbink, Gerrit J., van der Kooi, Anneke J., Raaphorst, Joost, Takkenberg, R. Bart, D’Haens, Geert R. A. M., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederike J., Voskuyl, Alexandre E., Broens, Bo, Sanchez, Agner Parra, van Els, Cécile A. C. M., de Wit, Jelle, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J. G. M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Renée C. F., Teng, Y. K. Onno, van Paassen, Pieter, Busch, Matthias H., Jallah, Papay B. P., Brusse, Esther, van Doorn, Pieter A., Baars, Adája E., Hijnen, Dirk Jan, Schreurs, Corine R. G., van der Pol, W. Ludo, Goedee, H. Stephan, Steenhuis, Maurice, Keijzer, Sofie, Keijser, Jim B. D., Cristianawati, Olvi, ten Brinke, Anja, Verstegen, Niels J. M., van Ham, S. Marieke, Rispens, Theo, Kuijpers, Taco W., Löwenberg, Mark, and Eftimov, Filip

Abstract

Additional file 1.

Published
2023
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118. Longitudinal SARS-CoV-2 humoral response in MS patients with and without SARS-CoV-2 infection prior to vaccination

Author

van Dam, Koos P. J., primary, Hogenboom, Laura, additional, Stalman, Eileen W., additional, Kummer, Laura Y. L., additional, Steenhuis, Maurice, additional, Keijser, Jim B. D., additional, Brinke, Anja ten, additional, van Ham, S. Marieke, additional, Kuijpers, Taco W., additional, Rispens, Theo, additional, Wieske, Luuk, additional, Eftimov, Filip, additional, Strijbis, Eva M., additional, Killestein, Joep, additional, and van Kempen, Zoé L. E., additional

Published
2022
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119. SARS-CoV-2 breakthrough infections in patients with immune-mediated inflammatory diseases during the omicron dominant period

Author

Boekel, Laura, primary, Besten, Yaëlle R, additional, Hooijberg, Femke, additional, Wartena, Rosa, additional, Steenhuis, Maurice, additional, Vogelzang, Erik, additional, Leeuw, Maureen, additional, Atiqi, Sadaf, additional, Tas, Sander W, additional, Lems, Willem F, additional, van Ham, S Marieke, additional, Eftimov, Filip, additional, Stalman, Eileen W, additional, Wieske, Luuk, additional, Kuijpers, Taco W, additional, Voskuyl, Alexandre E, additional, van Vollenhoven, Ronald F, additional, Gerritsen, Martijn, additional, Krieckaert, Charlotte, additional, Rispens, Theo, additional, Boers, Maarten, additional, Nurmohamed, Mike T, additional, and Wolbink, Gertjan, additional

Published
2022
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120. Comprehensive overview of autoantibody isotype and subclass distribution

Author

Volkov, Mikhail, primary, Coppola, Mariateresa, additional, Huizinga, Ruth, additional, Eftimov, Filip, additional, Huizinga, Tom W.J., additional, van der Kooi, Anneke J., additional, Oosten, Liesbeth E.M., additional, Raaphorst, Joost, additional, Rispens, Theo, additional, Sciarrillo, Rocco, additional, Titulaer, Maarten J., additional, Wieske, Luuk, additional, Toes, René E.M., additional, Huijbers, Maartje G.M., additional, van Schie, Karin A., additional, and van der Woude, Diane, additional

Published
2022
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121. Single-cell analysis reveals dynamics of human B cell differentiation and identifies novel B and antibody-secreting cell intermediates

Author

Verstegen, Niels J.M., primary, Pollastro, Sabrina, additional, Unger, Peter-Paul A., additional, Marsman, Casper, additional, Elias, George, additional, Jorritsma, Tineke, additional, Streutker, Marij, additional, Baβler, Kevin, additional, Händler, Kristian, additional, Rispens, Theo, additional, Schultze, Joachim L., additional, ten Brinke, Anja, additional, Beyer, Marc, additional, and van Ham, S. Marieke, additional

Published
2022
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122. Differences in systemic and mucosal SARS-CoV-2 antibody prevalence in a prospective cohort of Dutch children

Author

Keuning, Maya W., primary, Grobben, Marloes, additional, Bijlsma, Merijn W., additional, Anker, Beau, additional, Berman-de Jong, Eveline P., additional, Cohen, Sophie, additional, Felderhof, Mariet, additional, de Groen, Anne-Elise, additional, de Groof, Femke, additional, Rijpert, Maarten, additional, van Eijk, Hetty W. M., additional, Tejjani, Khadija, additional, van Rijswijk, Jacqueline, additional, Steenhuis, Maurice, additional, Rispens, Theo, additional, Plötz, Frans B., additional, van Gils, Marit J., additional, and Pajkrt, Dasja, additional

Published
2022
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123. Breakthrough infections with the SARS-CoV-2 omicron (B.1.1.529) variant in patients with immune-mediated inflammatory diseases

Author

Stalman, Eileen W, primary, Wieske, Luuk, additional, van Dam, Koos P J, additional, Kummer, Laura Y, additional, van Kempen, Zoé L E, additional, Killestein, Joep, additional, Volkers, Adriaan G, additional, Tas, Sander W, additional, Boekel, Laura, additional, Wolbink, Gertjan J, additional, Van der Kooi, Anneke J, additional, Raaphorst, Joost, additional, Löwenberg, Mark, additional, Takkenberg, R Bart, additional, D’Haens, Geert R A M, additional, Spuls, Phyllis I, additional, Bekkenk, Marcel W, additional, Musters, Annelie H, additional, Post, Nicoline F, additional, Bosma, Angela L, additional, Hilhorst, Marc L, additional, Vegting, Yosta, additional, Bemelman, Frederique J, additional, Voskuyl, Alexandre E, additional, Broens, Bo, additional, Parra Sanchez, Agner, additional, van Els, Cécile A C M, additional, Wit, Jelle De, additional, Rutgers, Abraham, additional, de Leeuw, Karina, additional, Horváth, Barbara, additional, Verschuuren, Jan J G M, additional, Ruiter, Annabel M, additional, van Ouwerkerk, Lotte, additional, van der Woude, Diane, additional, Allaart, C F, additional, Teng, Onno Y K, additional, van Paassen, Pieter, additional, Busch, Matthias H, additional, Jallah, Papay B P, additional, Brusse, Esther, additional, van Doorn, Pieter A, additional, Baars, Adája Elisabeth, additional, Hijnen, Dirk Jan, additional, Schreurs, Corine R G, additional, Van der Pol, W Ludo, additional, Goedee, H Stephan, additional, Steenhuis, Maurice, additional, Keijzer, Sofie, additional, Keijser, Jim B D, additional, Boogaard, Arend, additional, Cristianawati, Olvi, additional, ten Brinke, Anja, additional, Verstegen, Niels J M, additional, Zwinderman, Koos A H, additional, Rispens, Theo, additional, van Ham, S Marieke, additional, Kuijpers, Taco W, additional, and Eftimov, Filip, additional

Published
2022
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124. A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy

Author

Kapur, Rick, Kustiawan, Iwan, Vestrheim, Anne, Koeleman, Carolien A.M., Visser, Remco, Einarsdottir, Helga K., Porcelijn, Leendert, Jackson, Dave, Kumpel, Belinda, Deelder, André M., Blank, Dennis, Skogen, Björn, Killie, Mette Kjaer, Michaelsen, Terje E., de Haas, Masja, Rispens, Theo, van der Schoot, C. Ellen, Wuhrer, Manfred, and Vidarsson, Gestur

Published
2014
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126. Quality assessment and harmonization of laboratories across Europe for multiple SARS‐CoV‐2 serology assays.

Author

Steenhuis, Maurice, Wouters, Elise, Schrezenmeier, Hubert, Rispens, Theo, Tiberghien, Pierre, Harvala, Heli, Feys, Hendrik B., and van der Schoot, C. Ellen

Subjects
SARS-CoV-2, SEROLOGY, CONVALESCENT plasma, ANTIBODY titer
Abstract

Background and Objectives: There is a need for conversion of SARS‐CoV‐2 serology data from different laboratories to a harmonized international unit. We aimed to compare the performance of multiple SARS‐CoV‐2 antibody serology assays among 25 laboratories across 12 European countries. Materials and Methods: To investigate this we have distributed to all participating laboratories a panel of 15 SARS‐CoV‐2 plasma samples and a single batch of pooled plasma calibrated to the WHO IS 20/136 standard. Results: All assays showed excellent discrimination between SARS‐CoV‐2 seronegative plasma samples and pre‐vaccinated seropositive plasma samples but differed substantially in raw antibody titres. Titres could be harmonized to binding antibody units per millilitre by calibration in relation to a reference reagent. Conclusion: The standardization of antibody quantification is of paramount importance to allow interpretation and comparison of serology data reported in clinical trials in order to identify donor cohorts from whom the most effective convalescent plasma can be collected. [ABSTRACT FROM AUTHOR]

Published
2023
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127. At Critically Low Antigen Densities, IgM Hexamers Outcompete Both IgM Pentamers and IgG1 for Human Complement Deposition and Complement-Dependent Cytotoxicity

Author

Oskam, Nienke, Ooijevaar-de Heer, Pleuni, Derksen, Ninotska I L, Kruithof, Simone, de Taeye, Steven W, Vidarsson, Gestur, Reijm, Sanne, Kissel, Theresa, Toes, René E M, Rispens, Theo, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Medical Microbiology and Infection Prevention, Landsteiner Laboratory, and AII - Inflammatory diseases

Subjects
Immunoglobulin M, Immunoglobulin J-Chains, Immunoglobulin G, Immunology, Immunoglobulin J-Chains/metabolism, Immunology and Allergy, Humans, Complement System Proteins, Complement Activation
Abstract

IgM is secreted as a pentameric polymer containing a peptide called the joining chain (J chain). However, integration of the J chain is not required for IgM assembly and in its absence IgM predominantly forms hexamers. The conformations of pentameric and hexameric IgM are remarkably similar with a hexagonal arrangement in solution. Despite these similarities, hexameric IgM has been reported to be a more potent complement activator than pentameric IgM, but reported relative potencies vary across different studies. Because of these discrepancies, we systematically investigated human IgM-mediated complement activation. We recombinantly generated pentameric and hexameric human IgM (IgM+J and IgM−J, respectively) mAbs and measured their ability to induce complement deposition and complement-dependent cytotoxicity when bound to several Ags at varying densities. At high Ag densities, hexameric and pentameric IgM activate complement to a similar extent as IgG1. However, at low densities, hexameric IgM outcompeted pentameric IgM and even more so IgG1. These differences became progressively more pronounced as antigenic density became critically low. Our findings highlight that the differential potency of hexameric and pentameric IgM for complement activation is profoundly dependent on the nature of its interactions with Ag. Furthermore, it underscores the importance of IgM in immunity because it is a more potent complement activator than IgG1 at low Ag densities.

Published
2022

129. ESDR126 - Serum dupilumab levels after 16 weeks of treatment are not associated with treatment response or side effects in atopic dermatitis patients

Author

Spekhorst, Lotte, primary, de Graaf, Marlies, primary, Loeff, Floris, primary, Zuithoff, Nicolaas, primary, Bakker, Daphne, primary, Boesjes, Celeste, primary, Thijs, Judith, primary, Achten, Roselie, primary, van Wijk, Femke, primary, Rispens, Theo, primary, and de Bruin-Weller, Marjolein, primary

Published
2022
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131. Patient‐centered dupilumab dosing regimen leads to successful dose reduction in persistently controlled atopic dermatitis

Author

Spekhorst, Lotte S., primary, Bakker, Daphne, additional, Drylewicz, Julia, additional, Rispens, Theo, additional, Loeff, Floris, additional, Boesjes, Celeste M., additional, Thijs, Judith, additional, Romeijn, Geertruida L. E., additional, Loman, Laura, additional, Schuttelaar, Marie‐Louise, additional, van Wijk, Femke, additional, de Graaf, Marlies, additional, and de Bruin‐Weller, Marjolein S., additional

Published
2022
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132. Immunoassay for quantification of antigen-specific IgG fucosylation

Author

Šuštić, Tonći, primary, Van Coillie, Julie, additional, Larsen, Mads Delbo, additional, Derksen, Ninotska I.L., additional, Szittner, Zoltan, additional, Nouta, Jan, additional, Wang, Wenjun, additional, Damelang, Timon, additional, Rebergen, Ianthe, additional, Linty, Federica, additional, Visser, Remco, additional, Mok, Juk Yee, additional, Geerdes, Dionne M., additional, van Esch, Wim J.E., additional, de Taeye, Steven W., additional, van Gils, Marit J., additional, van de Watering, Leo, additional, van der Schoot, C. Ellen, additional, Wuhrer, Manfred, additional, Rispens, Theo, additional, and Vidarsson, Gestur, additional

Published
2022
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134. Author response: Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273

Author

Verstegen, Niels JM, primary, Hagen, Ruth R, additional, van den Dijssel, Jet, additional, Kuijper, Lisan H, additional, Kreher, Christine, additional, Ashhurst, Thomas, additional, Kummer, Laura YL, additional, Steenhuis, Maurice, additional, Duurland, Mariel, additional, de Jongh, Rivka, additional, de Jong, Nina, additional, van der Schoot, C Ellen, additional, Bos, Amélie V, additional, Mul, Erik, additional, Kedzierska, Katherine, additional, van Dam, Koos PJ, additional, Stalman, Eileen W, additional, Boekel, Laura, additional, Wolbink, Gertjan, additional, Tas, Sander W, additional, Killestein, Joep, additional, van Kempen, Zoé LE, additional, Wieske, Luuk, additional, Kuijpers, Taco W, additional, Eftimov, Filip, additional, Rispens, Theo, additional, van Ham, S Marieke, additional, ten Brinke, Anja, additional, and van de Sandt, Carolien E, additional

Published
2022
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135. Breakthrough SARS-CoV-2 infections with the delta (B.1.617.2) variant in vaccinated patients with immune-mediated inflammatory diseases using immunosuppressants: a substudy of two prospective cohort studies

Author

Boekel, Laura, primary, Stalman, Eileen W, additional, Wieske, Luuk, additional, Hooijberg, Femke, additional, van Dam, Koos P J, additional, Besten, Yaëlle R, additional, Kummer, Laura Y L, additional, Steenhuis, Maurice, additional, van Kempen, Zoé L E, additional, Killestein, Joep, additional, Volkers, Adriaan G, additional, Tas, Sander W, additional, van der Kooi, Anneke J, additional, Raaphorst, Joost, additional, Löwenberg, Mark, additional, Takkenberg, R Bart, additional, D'Haens, Geert R A M, additional, Spuls, Phyllis I, additional, Bekkenk, Marcel W, additional, Musters, Annelie H, additional, Post, Nicoline F, additional, Bosma, Angela L, additional, Hilhorst, Marc L, additional, Vegting, Yosta, additional, Bemelman, Frederike J, additional, Voskuyl, Alexandre E, additional, Broens, Bo, additional, Parra Sanchez, Agner, additional, van Els, Cécile A C M, additional, de Wit, Jelle, additional, Rutgers, Abraham, additional, de Leeuw, Karina, additional, Horváth, Barbara, additional, Verschuuren, Jan J G M, additional, Ruiter, Annabel M, additional, van Ouwerkerk, Lotte, additional, van der Woude, Diane, additional, Allaart, Cornelia F, additional, Teng, Y K Onno, additional, van Paassen, Pieter, additional, Busch, Matthias H, additional, Jallah, Papay B P, additional, Brusse, Esther, additional, van Doorn, Pieter A, additional, Baars, Adája E, additional, Hijnen, Dirk Jan, additional, Schreurs, Corine R G, additional, van der Pol, W Ludo, additional, Goedee, H Stephan, additional, Vogelzang, Erik H, additional, Leeuw, Maureen, additional, Atiqi, Sadaf, additional, van Vollenhoven, Ronald, additional, Gerritsen, Martijn, additional, van der Horst-Bruinsma, Irene E, additional, Lems, Willem F, additional, Nurmohamed, Mike T, additional, Boers, Maarten, additional, Keijzer, Sofie, additional, Keijser, Jim, additional, van de Sandt, Carolien, additional, Boogaard, Arend, additional, Cristianawati, Olvi, additional, ten Brinke, Anja, additional, Verstegen, Niels J M, additional, Zwinderman, Koos A H, additional, van Ham, S Marieke, additional, Rispens, Theo, additional, Kuijpers, Taco W, additional, Wolbink, Gertjan, additional, Eftimov, Filip, additional, de Jongh, Rivka, additional, Kuijper, Lisan, additional, Duurland, Mariel, additional, Hagen, Ruth, additional, van den Dijssel, Jet, additional, Kreher, Christine, additional, Bos, Amelie, additional, Palomares Cabeza, Viriginia, additional, Konijn, Veronique, additional, Elias, George, additional, Vallejo, Juan, additional, van Gils, Marrit, additional, Ashhurst, Tom, additional, Nejentsev, Sergey, additional, and Mirfazeli, Elham, additional

Published
2022
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137. At Critically Low Antigen Densities, IgM Hexamers Outcompete Both IgM Pentamers and IgG1 for Human Complement Deposition and Complement-Dependent Cytotoxicity

Author

Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Oskam, Nienke, Ooijevaar-de Heer, Pleuni, Derksen, Ninotska I L, Kruithof, Simone, de Taeye, Steven W, Vidarsson, Gestur, Reijm, Sanne, Kissel, Theresa, Toes, René E M, Rispens, Theo, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Oskam, Nienke, Ooijevaar-de Heer, Pleuni, Derksen, Ninotska I L, Kruithof, Simone, de Taeye, Steven W, Vidarsson, Gestur, Reijm, Sanne, Kissel, Theresa, Toes, René E M, and Rispens, Theo

Published
2022

138. The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

Author

Sub Cell Biology, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Brinkhaus, Maximilian, Pannecoucke, Erwin, van der Kooi, Elvera J., Bentlage, Arthur E.H., Derksen, Ninotska I.L., Andries, Julie, Balbino, Bianca, Sips, Magdalena, Ulrichts, Peter, Verheesen, Peter, de Haard, Hans, Rispens, Theo, Savvides, Savvas N., Vidarsson, Gestur, Sub Cell Biology, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Brinkhaus, Maximilian, Pannecoucke, Erwin, van der Kooi, Elvera J., Bentlage, Arthur E.H., Derksen, Ninotska I.L., Andries, Julie, Balbino, Bianca, Sips, Magdalena, Ulrichts, Peter, Verheesen, Peter, de Haard, Hans, Rispens, Theo, Savvides, Savvas N., and Vidarsson, Gestur

Published
2022

139. Immunoassay for quantification of antigen-specific IgG fucosylation

Author

Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Šuštić, Tonći, Van Coillie, Julie, Larsen, Mads Delbo, Derksen, Ninotska I L, Szittner, Zoltan, Nouta, Jan, Wang, Wenjun, Damelang, Timon, Rebergen, Ianthe, Linty, Federica, Visser, Remco, Mok, Juk Yee, Geerdes, Dionne M, van Esch, Wim J E, de Taeye, Steven W, van Gils, Marit J, van de Watering, Leo, van der Schoot, C Ellen, Wuhrer, Manfred, Rispens, Theo, Vidarsson, Gestur, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Šuštić, Tonći, Van Coillie, Julie, Larsen, Mads Delbo, Derksen, Ninotska I L, Szittner, Zoltan, Nouta, Jan, Wang, Wenjun, Damelang, Timon, Rebergen, Ianthe, Linty, Federica, Visser, Remco, Mok, Juk Yee, Geerdes, Dionne M, van Esch, Wim J E, de Taeye, Steven W, van Gils, Marit J, van de Watering, Leo, van der Schoot, C Ellen, Wuhrer, Manfred, Rispens, Theo, and Vidarsson, Gestur

Published
2022

140. Adalimumab with Methotrexate vs. Adalimumab Monotherapy in Psoriasis:First-Year Results of a Single-Blind Randomized Controlled Trial

Author

van der Kraaij, Gayle, Busard, Celine, van den Reek, Juul, Menting, Stef, Musters, Annelie, Hutten, Barbara, de Rie, Menno, Ouwerkerk, Wouter, van Bezooijen, Sun Jine, Prens, Errol, Rispens, Theo, de Vries, Annick, de Jong, Elke, de Kort, Wim, Lambert, Jo, van Doorn, Martijn, Spuls, Phyllis, van der Kraaij, Gayle, Busard, Celine, van den Reek, Juul, Menting, Stef, Musters, Annelie, Hutten, Barbara, de Rie, Menno, Ouwerkerk, Wouter, van Bezooijen, Sun Jine, Prens, Errol, Rispens, Theo, de Vries, Annick, de Jong, Elke, de Kort, Wim, Lambert, Jo, van Doorn, Martijn, and Spuls, Phyllis

Abstract

Introduction: Adalimumab is normally prescribed with methotrexate (MTX) in rheumatoid arthritis given the enhanced treatment effect and reduced antidrug antibody formation compared with adalimumab monotherapy (ADL). In psoriasis, the long-term treatment effects and pharmacokinetic profile have not been investigated extensively. Methods: We conducted a randomized controlled trial to assess the efficacy, safety, pharmacokinetics, and immunogenicity of adalimumab combined with MTX 10 mg per week (ADL-MTX group) compared with that of ADL (ADL group) in chronic plaque psoriasis. Results: A total of 31 patients in the ADL-MTX group and 30 in the ADL group were analyzed. After 1 year, a (nonsignificant) better drug survival was found in the ADL-MTX group (74.2 vs. 58.6%, P = 0.15). The PASI 75 response in week 49 was 58.1 versus 36.7% (P = 0.13), and the median (interquartile range) serum-trough concentrations were 6.8 (5.5‒9.2) versus 5.9 (3.5‒8.8) mg/l (P = 0.26) in the ADL-MTX group and ADL group, respectively. Fewer patients showed antidrug antibodies in the ADL-MTX group (22.6 vs. 60.0%, P < 0.01). No serious adverse events occurred. Conclusion: Combination therapy of adalimumab and MTX results in fewer patients showing antidrug antibodies, with a trend toward a better PASI 75 response, drug survival, and higher serum-trough concentrations than ADL. Patient-reported outcomes and adverse events were comparable between the groups.

Published
2022

141. Comprehensive overview of autoantibody isotype and subclass distribution

Author

Volkov, Mikhail, Coppola, Mariateresa, Huizinga, Ruth, Eftimov, Filip, Huizinga, Tom W.J., van der Kooi, Anneke J., Oosten, Liesbeth E.M., Raaphorst, Joost, Rispens, Theo, Sciarrillo, Rocco, Titulaer, Maarten J., Wieske, Luuk, Toes, René E.M., Huijbers, Maartje G.M., van Schie, Karin A., van der Woude, Diane, Volkov, Mikhail, Coppola, Mariateresa, Huizinga, Ruth, Eftimov, Filip, Huizinga, Tom W.J., van der Kooi, Anneke J., Oosten, Liesbeth E.M., Raaphorst, Joost, Rispens, Theo, Sciarrillo, Rocco, Titulaer, Maarten J., Wieske, Luuk, Toes, René E.M., Huijbers, Maartje G.M., van Schie, Karin A., and van der Woude, Diane

Abstract

The presence of autoreactive antibodies is a hallmark of many autoimmune diseases. The effector functions of (auto)antibodies are determined by their constant domain, which defines the antibody isotype and subclass. The most prevalent isotype in serum is IgG, which is often the only isotype used in diagnostic testing. Nevertheless, autoantibody responses can have their own unique isotype/subclass profile. Because comparing autoantibody isotype profiles may yield new insights into disease pathophysiology, here we summarize the isotype/subclass profiles of the most prominent autoantibodies. Despite substantial variation between (and within) autoantibody responses, this unprecedented comparison shows that autoantibodies share distinctive isotype patterns across different diseases. Although most autoantibody responses are dominated by IgG (and mainly IgG1), several specific diseases are characterized by a predominance of IgG4. In other diseases, IgE plays a key role. Importantly, shared features of autoantibody isotype/subclass profiles are seen in clinically unrelated diseases, suggesting potentially common trajectories in response evolution, disease pathogenesis, and treatment response. Isotypes beyond IgG are scarcely investigated in many autoantibody responses, leaving substantial gaps in our understanding of the pathophysiology of autoimmune diseases. Future research should address isotype/subclass profiling in more detail and incorporate autoantibody measurements beyond total IgG in disease models and clinical studies.

Published
2022

142. Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation

Author

Kissel, Theresa, Ge, Changrong, Hafkenscheid, Lise, Kwekkeboom, Joanneke C., Slot, Linda M., Cavallari, Marco, He, Yibo, van Schie, Karin A., Vergroesen, Rochelle D., Kampstra, Arieke S.B., Reijm, Sanne, Stoeken-Rijsbergen, Gerrie, Koeleman, Carolien, Voortman, Lennard M., Heitman, Laura H., Xu, Bingze, Pruijn, Ger J.M., Wuhrer, Manfred, Rispens, Theo, Huizinga, Tom W.J., Scherer, Hans Ulrich, Reth, Michael, Holmdahl, Rikard, Toes, Rene E.M., Kissel, Theresa, Ge, Changrong, Hafkenscheid, Lise, Kwekkeboom, Joanneke C., Slot, Linda M., Cavallari, Marco, He, Yibo, van Schie, Karin A., Vergroesen, Rochelle D., Kampstra, Arieke S.B., Reijm, Sanne, Stoeken-Rijsbergen, Gerrie, Koeleman, Carolien, Voortman, Lennard M., Heitman, Laura H., Xu, Bingze, Pruijn, Ger J.M., Wuhrer, Manfred, Rispens, Theo, Huizinga, Tom W.J., Scherer, Hans Ulrich, Reth, Michael, Holmdahl, Rikard, and Toes, Rene E.M.

Abstract

The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain glycans (VDGs). Their abundant occurrence results from the selective introduction of N-linked glycosylation sites during somatic hypermutation, and their presence is predictive for disease development. However, the functional consequences of VDGs on autoreactive B cells remain elusive. Combining crystallography, glycobiology, and functional B cell assays allowed us to dissect key characteristics of VDGs on human B cell biology. Crystal structures showed that VDGs are positioned in the vicinity of the antigen-binding pocket, and dynamic modeling combined with binding assays elucidated their impact on binding. We found that VDG-expressing B cell receptors stay longer on the B cell surface and that VDGs enhance B cell activation. These results provide a rationale on how the acquisition of VDGs might contribute to the breach of tolerance of autoreactive B cells in a major human autoimmune disease.

Published
2022

143. Association of Serum Dupilumab Levels at 16 Weeks with Treatment Response and Adverse Effects in Patients with Atopic Dermatitis: A Prospective Clinical Cohort Study from the BioDay Registry

Author

MS Dermatologie/Allergologie, Infection & Immunity, Biostatistiek Onderzoek, Other research (not in main researchprogram), Unit Opleiding Dermatologie, CTI Van Wijk, Child Health, Spekhorst, Lotte S., De Graaf, Marlies, Loeff, Floris, Zuithoff, Nicolaas P.A., Bakker, Daphne, Boesjes, Celeste M., Thijs, Judith, Achten, Roselie, Van Wijk, Femke, Rispens, Theo, De Bruin-Weller, Marjolein S., MS Dermatologie/Allergologie, Infection & Immunity, Biostatistiek Onderzoek, Other research (not in main researchprogram), Unit Opleiding Dermatologie, CTI Van Wijk, Child Health, Spekhorst, Lotte S., De Graaf, Marlies, Loeff, Floris, Zuithoff, Nicolaas P.A., Bakker, Daphne, Boesjes, Celeste M., Thijs, Judith, Achten, Roselie, Van Wijk, Femke, Rispens, Theo, and De Bruin-Weller, Marjolein S.

Published
2022

144. Patient-centered dupilumab dosing regimen leads to successful dose reduction in persistently controlled atopic dermatitis

Author

MS Dermatologie/Allergologie, Infection & Immunity, Unit Opleiding Dermatologie, CTI Computational Immunology Core, CTI Van Wijk, Child Health, Spekhorst, Lotte S, Bakker, Daphne, Drylewicz, Julia, Rispens, Theo, Loeff, Floris, Boesjes, Celeste M, Thijs, Judith, Romeijn, Geertruida L E, Loman, Laura, Schuttelaar, Marie-Louise, van Wijk, Femke, de Graaf, Marlies, de Bruin-Weller, Marjolein S, MS Dermatologie/Allergologie, Infection & Immunity, Unit Opleiding Dermatologie, CTI Computational Immunology Core, CTI Van Wijk, Child Health, Spekhorst, Lotte S, Bakker, Daphne, Drylewicz, Julia, Rispens, Theo, Loeff, Floris, Boesjes, Celeste M, Thijs, Judith, Romeijn, Geertruida L E, Loman, Laura, Schuttelaar, Marie-Louise, van Wijk, Femke, de Graaf, Marlies, and de Bruin-Weller, Marjolein S

Published
2022

148. SARS-CoV-2 omicron breakthrough infections in patients with multiple sclerosis.

Author

van Kempen, Zoé L. E., Stalman, Eileen W., Steenhuis, Maurice, Kummer, Laura Y. L., van Dam, Koos P. J., Wilbrink, Maarten F., ten Brinke, Anja, Marieke van Ham, S., Kuijpers, Taco, Rispens, Theo, Eftimov, Filip, Wieske, Luuk, and Killestein, Joep

Subjects
BREAKTHROUGH infections, SARS-CoV-2 Omicron variant, MULTIPLE sclerosis, SARS-CoV-2, CONVALESCENT plasma, JOHN Cunningham virus
Published
2023
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149. Fingerprick blood samples to measure serum natalizumab concentrations.

Author

Toorop, Alyssa A, Steenhuis, Maurice, Loeff, Floris C, Weijers, Suzanne S, Killestein, Joep, Rispens, Theo, and Kempen, Zoé LE van

Subjects
NATALIZUMAB, BLOOD sampling, DRUG monitoring, MULTIPLE sclerosis, PHYSICIANS
Abstract

Background: Natalizumab via subcutaneous administration was recently approved for patients with multiple sclerosis. Objective: In light of personalized extended dosing, in which treatment intervals are prolonged to a concentration cut-off, it would be preferable to measure natalizumab drug concentrations in capillary blood. Methods: In this cross-sectional study in patients treated with intravenous (IV) natalizumab, capillary blood samples by fingerprick and venous blood samples were collected in 30 participants prior to IV administration of natalizumab. Results: Natalizumab concentrations were similar with a mean bias of −0.36 μg/mL (95% CI: 1.3 to −2 μg/mL). Conclusions: This study shows that physicians can monitor natalizumab drug concentrations by a fingerprick, which could be used for personalized extended dosing. [ABSTRACT FROM AUTHOR]

Published
2023
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150. COVID-19 vaccine acceptance over time in patients with immune-mediated inflammatory rheumatic diseases

Author

Boekel, Laura, Hooijberg, Femke, Besten, Yaëlle R, Vogelzang, Erik H, Steenhuis, Maurice, Leeuw, Maureen, Atiqi, Sadaf, van Vollenhoven, Ronald, Lems, Willem F, Bos, Wouter H, Wijbrandts, Carla A, Gerritsen, Martijn, Krieckaert, Charlotte, Voskuyl, Alexandre E, van der Horst-Bruinsma, Irene E, Tas, Sander W, Boers, Maarten, Rispens, Theo, Nurmohamed, Michael T, and Wolbink, Gertjan

Published
2022
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