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104. Gender differences in the use of cardiovascular interventions in HIV‐positive persons; the D:A:D Study

Author

Hatleberg, Camilla I., Ryom, Lene, El?Sadr, Wafaa, Mocroft, Amanda, Reiss, Peter, De Wit, Stephane, Dabis, Francois, Pradier, Christian, Monforte, Antonella D'Arminio, Kovari, Helen, Law, Matthew, Lundgren, Jens D., Sabin, Caroline A., Calvo, G, Bonnet, F, Kirk, O, Morfeldt, L, Weber, R, Lind?Thomsen, A, Brandt, R Salbøl, Hillebreght, M, Zaheri, S, Wit, Fwnm, Scherrer, A, Schöni?Affolter, F, Rickenbach, M, Tavelli, A, Fanti, I, Leleux, O, Mourali, J, Le Marec, F, Boerg, E, Thulin, E, Sundström, A, Bartsch, G, Thompsen, G, Necsoi, C, Delforge, M, Fontas, E, Caissotti, C, Mateu, S, Torres, F, Petoumenos, K, Blance, A, Huang, R, Puhr, R, Laut, K, Kristensen, D, Phillips, An, Kamara, Da, Smith, Cj, Brandt, Rs, Raben, D, Matthews, C, Bojesen, A, Grevsen, Al, Powderly, B, Shortman, N, Moecklinghoff, C, Reilly, G, Franquet, X, Smit, C, Ross, M, Fux, Ca, Morlat, P, Friis?Møller, N, Kowalska, J, Bohlius, J, Bower, M, Fätkenheuer, G, Grulich, A, Sjøl, A, Meidahl, P, Iversen, Js, Hillebregt, M, Prins, Jm, Kuijpers, Tw, Scherpbier, Hj, Meer, Jtm, Godfried, Mh, Poll, T, Nellen, Fjb, Geerlings, Se, Vugt, M, Pajkrt, D, Bos, Jc, Wiersinga, Wj, Valk, M, Goorhuis, A, Hovius, Jw, Eden, J, Henderiks, A, Hes, Amh, Mutschelknauss, M, Nobel, He, Pijnappel, Fjj, Jurriaans, S, Back, Nkt, Zaaijer, Hl, Berkhout, B, Cornelissen, Mte, Schinkel, Cj, Thomas, Xv, Ziekenhuis, A De Ruyter, Berge, M, Stegeman, A, Baas, S, De Looff, L Hage, Ziekenhuis, C, Pronk, Mjh, Ammerlaan, Hsm, Munnik, E, Tjhie, J, Wegdam, Mca, Deiman, B, Scharnhorst, V, Weijsenfeld, Am, Ende, Me, Gorp, Ecm, Schurink, Cam, Nouwen, Jl, Verbon, A, Rijnders, Bja, Bax, Hi, Feltz, M, Bassant, N, Beek, Jea, Vriesde, M, Zonneveld, Lm, Oude?Lubbers, A, Berg?Cameron, Hj, Bruinsma?Broekman, Fb, Groot, J, Man, M Zeeuw?De, Boucher, Cab, Koopmans, Mpg, Kampen, Jja, Pas, Sd, Driessen, Gja, Rossum, Amc, Knaap, Lc, Flevoziekenhuis, E, Branger, J, Rijkeboer?Mes, A, Schippers, Ef, Ijperen, Jm, Geilings, J, Hut, G, Franck, Pfh, Eeden, A, Brokking, W, Groot, M, Elsenburg, Ljm, Damen, M, Isala, Is, Groeneveld, Php, Bouwhuis, Jw, Berg, Jf, Hulzen, Agw, Bliek, Gl, Bor, Pcj, Bloembergen, P, Wolfhagen, Mjhm, Ruijs, Gjhm, Kroon, Fp, Boer, Mgj, Bauer, Mp, Jolink, H, Vollaard, Am, Dorama, W, Holten, N, Claas, Ecj, Wessels, E, Den Hollander, Jg, Pogany, K, Roukens, A, Kastelijns, M, Smit, Jv, Smit, E, Struik?Kalkman, D, Tearno, C, Bezemer, M, Niekerk, T, Pontesilli, O, Lowe, Sh, Lashof, Aml Oude, Posthouwer, D, Ackens, Rp, Schippers, J, Vergoossen, R, Weijenberg?Maes, B, Loo, Ihm, Havenith, Tra, Leyten, Ems, Gelinck, Lbs, Hartingsveld, A, Meerkerk, C, Wildenbeest, Gs, Mutsaers, Jaem, Jansen, Cl, Mulder, Jw, Vrouenraets, Sme, Lauw, Fn, Broekhuizen, Mc, Paap, H, Vlasblom, Dj, Smits, Phm, Weijer, S, Moussaoui, R El, Bosma, As, Vonderen, Mga, Houte, Dpf, Kampschreur, Lm, Dijkstra, K, Faber, S, Weel, J, Kootstra, Gj, Delsing, Ce, De Plas, M Burg?Van, Heins, H, Lucas, E, Kortmann, W, Twillert¤, G, Stuart, Jwt Cohen, Diederen, Bmw, Pronk, D, Truijen?Oud, Fa, Reijden, Wa, Jansen, R, Brinkman¤, K, Berk, Gel, Blok, Wl, Frissen, Phj, Lettinga, Kd, Schouten, Wem, Veenstra, J, Brouwer, Cj, Geerders, Gf, Hoeksema, K, Kleene, Mj, Meché, Ib, Spelbrink, M, Sulman, H, Toonen, Ajm, Wijnands, S, Kwa, D, Witte, E, Koopmans, Pp, Keuter, M, Ven, Ajam, Hofstede, Hjm, Dofferhoff, Asm, Crevel, R, Albers, M, Bosch, Mew, Grintjes?Huisman, Kjt, Zomer, Bj, Stelma, Ff, Rahamat?Langendoen, J, Burger, D, Richter, C, Gisolf, Eh, Hassing, Rj, Beest, G, Van Bentum, Phm, Langebeek, N, Tiemessen, R, Swanink, Cma, Lelyveld, Sfl, Soetekouw, R, Hulshoff, N, Prijt, Lmm, Swaluw, J, Bermon, N, Herpers, Bl, Veenendaal, D, Verhagen, Dwm, Wijk, M, Brouwer, Ae, Kuipers, M, Santegoets, Rmwj, Ven, B, Marcelis, Jh, Buiting, Agm, Kabel, Pj, Bierman, Wfw, Scholvinck, H, Wilting, Kr, Stienstra, Y, Meulen, Pa, Weerd, Da, Ludwig?Roukema, J, Niesters, Hgm, Riezebos?Brilman, A, Leer?Buter, Cc, Knoester, M, Hoepelman, Aim, Mudrikova, T, Ellerbroek, Pm, Oosterheert, Jj, Arends, Je, Barth, Re, Wassenberg, Mwm, Schadd, Em, Elst?Laurijssen, Dhm, Oers?Hazelzet, Eeb, Vervoort, S, Berkel, M, Schuurman, R, Verduyn?Lunel, F, Wensing, Amj, Peters, Ejg, Agtmael, Ma, Bomers, M, Vocht, J, Heitmuller, M, Laan, Lm, Pettersson, Am, Ang, Cw, Geelen, Spm, Wolfs, Tfw, Bont, Lj, Bezemer, Do, Sighem, Ai, Boender, Ts, Jong, A, Bergsma, D, Hoekstra, P, Lang, A, Grivell, S, Jansen, A, Rademaker, Mj, Raethke, M, Meijering, R, Schnörr, S, Groot, L, Akker, M, Bakker, Y, Claessen, E, Berkaoui, A El, Koops, J, Kruijne, E, Lodewijk, C, Munjishvili, L, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Rutkens, T, Sande, L, Schoorl, M, Timmerman, A, Tuijn, E, Veenenberg, L, Vliet, S, Wisse, A, Woudstra, T, Tuk, B, Dupon, M, Gaborieau, V, Lacoste, D, Malvy, D, Mercié, P, Neau, D, Pellegrin, Jl, Tchamgoué, S, Lazaro, E, Cazanave, C, Vandenhende, M, Vareil, Mo, Gérard, Y, Blanco, P, Bouchet, S, Breilh, D, Fleury, H, Pellegrin, I, Chêne, G, Thiébaut, R, Wittkop, L, Lawson?Ayayi, S, Gimbert, A, Desjardin, S, Lacaze?Buzy, L, Petrov?Sanchez, V, André, K, Bernard, N, Caubet, O, Caunegre, L, Chossat, I, Courtault, C, Dauchy, Fa, Dondia, D, Duffau, P, Dutronc, H, Farbos, S, Faure, I, Ferrand, H, Gerard, Y, Greib, C, Hessamfar, M, Imbert, Y, Lataste, P, Marie, J, Mechain, M, Monlun, E, Ochoa, A, Pistone, T, Raymond, I, Receveur, Mc, Rispal, P, Sorin, L, Valette, C, Vandenhende, Ma, Viallard, Jf, Wille, H, Wirth, G, Lafon, Me, Trimoulet, P, Bellecave, P, Tumiotto, C, Haramburu, F, Miremeont?Salamé, G, Blaizeau, Mj, Decoin, M, Hannapier, C, Pougetoux, E Lenaud Et A., Delveaux, S, D' Ivernois, C, Diarra, F, Uwamaliya?Nziyumvira, B, Palmer, G, Conte, V, Sapparrart, V, Moore, R, Edwards, S, Hoy, J, Watson, K, Roth, N, Lau, H, Bloch, M, Baker, D, Carr, A, Cooper, D, O'Sullivan, M, Nolan, D, Guelfi, G, Domingo, P, Sambeat, Ma, Gatell, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, Clumeck, N, Gennotte, Af, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Martin, C, Payen, Mc, Semaille, P, Laethem, Y, Neaton, J, Krum, E, Thompson, G, Luskin?Hawk, R, Telzak, E, Abrams, Di, Cohn, D, Markowitz, N, Arduino, R, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Crane, Lr, Sampson, J, Baxter, J, Gazzard, B, Horban, A, Karpov, I, Losso, M, Pedersen, C, Ristola, M, Phillips, A, Rockstroh, J, Peters, L, Fischer, Ah, Laut, K Grønborg, Larsen, Jf, Podlekareva, D, Cozzi?Lepri, A, Shepherd, L, Schultze, A, Amele, S, Kundro, M, Schmied, B, Vassilenko, A, Mitsura, Vm, Paduto, D, Florence, E, Vandekerckhove, L, Hadziosmanovic, V, Begovac, J, Machala, L, Jilich, D, Kronborg, G, Benfield, T, Gerstoft, J, Katzenstein, T, Møller, Nf, Ostergaard, L, Wiese, L, Nielsen, Ln, Zilmer, K, Aho, I, Viard, J?P, Girard, P?M, Duvivier, C, Degen, O, Stellbrink, Hj, Stefan, C, Bogner, J, Chkhartishvili, N, Gargalianos, P, Szlávik, J, Gottfredsson, M, Mulcahy, F, Yust, I, Turner, D, Burke, M, Shahar, E, Hassoun, G, Elinav, H, Haouzi, M, Elbirt, D, Sthoeger, Zm, Esposito, R, Mazeu, I, Mussini, C, Mazzotta, F, Gabbuti, A, Vullo, V, Lichtner, M, Zaccarelli, M, Antinori, A, Acinapura, R, Plazzi, M, Lazzarin, A, Castagna, A, Gianotti, N, Galli, M, Ridolfo, A, Rozentale, B, Uzdaviniene, V, Staub, T, Ormaasen, V, Maeland, A, Bruun, J, Knysz, B, Gasiorowski, J, Inglot, M, Bakowska, E, Flisiak, R, Grzeszczuk, A, Parczewski, M, Maciejewska, K, Aksak?Was, B, Beniowski, M, Mularska, E, Smiatacz, T, Gensing, M, Jablonowska, E, Malolepsza, E, Wojcik, K, Mozer?Lisewska, I, Caldeira, L, Radoi, R, Panteleev, A, Yakovlev, A, Trofimora, T, Khromova, I, Kuzovatova, E, Borodulina, E, Vdoushkina, E, Jevtovic, D, Tomazic, J, Gatell, Jm, Miró, Jm, Moreno, S, Rodriguez, Jm, Clotet, B, Jou, A, Paredes, R, Tural, C, Puig, J, Bravo, I, Gutierrez, M, Mateo, G, Laporte, Jm, Falconer, K, Thalme, A, Sonnerborg, A, Blaxhult, A, Flamholc, L, Cavassini, M, Calmy, A, Furrer, H, Schmid, P, Kuznetsova, A, Kyselyova, G, Sluzhynska, M, Johnson, Am, Simons, E, Johnson, Ma, Orkin, C, Weber, J, Scullard, G, Clarke, A, Leen, C, Thulin, G, Åkerlund, B, Koppel, K, Karlsson, A, Håkangård, C, Castelli, F, Cauda, R, Di Perri, G, Iardino, R, Ippolito, G, Marchetti, Gc, Perno, Cf, Schloesser, F, Viale, P, Ceccherini?Silberstein, F, Girardi, E, Lo Caputo, S, Puoti, M, Andreoni, M, Ammassari, A, Balotta, C, Bandera, A, Bonfanti, P, Bonora, S, Borderi, M, Calcagno, A, Calza, L, Capobianchi, Mr, Cingolani, A, Cinque, P, De Luca, A, Di Biagio, A, Gori, A, Guaraldi, G, Lapadula, G, Madeddu, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Monno, L, Nozza, S, Roldan, E Quiros, Rossotti, R, Rusconi, S, Santoro, Mm, Saracino, A, Galli, L, Lorenzini, P, Rodano, A, Shanyinde, M, Carletti, F, Carrara, S, Di Caro, A, Graziano, S, Petrone, F, Prota, G, Quartu, S, Truffa, S, Giacometti, A, Costantini, A, Barocci, V, Angarano, G, Santoro, C, Suardi, C, Donati, V, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, Pe, Piano, P, Cacopardo, B, Celesia, B, Vecchiet, J, Falasca, K, Pan, A, Lorenzotti, S, Sighinolfi, L, Segala, D, Vichi, F, Cassola, G, Viscoli, C, Alessandrini, A, Bobbio, N, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Milini, P, Rizzardini, G, Moioli, Mc, Piolini, R, Ridolfo, Al, Salpietro, S, Tincati, C, Puzzolante, C, Abrescia, N, Chirianni, A, Borgia, G, Orlando, R, Bonadies, G, Di Martino, F, Gentile, I, Maddaloni, L, Cattelan, Am, Marinello, S, Cascio, A, Colomba, C, Baldelli, F, Schiaroli, E, Parruti, G, Sozio, F, Magnani, G, Ursitti, Ma, Cristaudo, A, Baldin, G, Capozzi, M, Cicalini, S, Sulekova, L Fontanelli, Iaiani, G, Latini, A, Mastrorosa, I, Plazzi, Mm, Savinelli, S, Vergori, A, Cecchetto, M, Viviani, F, Bagella, P, Rossetti, B, Franco, A, Del Vecchio, R Fontana, Francisci, D, Di Giuli, C, Caramello, P, Orofino, Gc, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Starnini, G, Ialungo, A, Dollet, K, Dellamonica, P, Bernard, E, Courjon, J, Cua, E, De Salvador?Guillouet, F, Durant, J, Etienne, C, Ferrando, S, Mondain?Miton, V, Naqvi, A, Perbost, I, Pillet, S, Prouvost?Keller, B, Pugliese, P, Rio, V, Risso, K, Roger, Pm, Aubert, V, Battegay, M, Bernasconi, E, Böni, J, Braun, Dl, Bucher, Hc, Ciuffi, A, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Günthard, Hf, Haerry, D, Hasse, B, Hirsch, Hh, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, Rd, Ledergerber, B, Martinetti, G, De Tejada, B Martinez, Marzolini, C, Metzner, Kj, Müller, N, Nicca, D, Pantaleo, G, Paioni, P, Rauch, A, Rudin, C, Scherrer, Au, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Wandeler, G, and Yerly, S

Subjects
Medical care -- Utilization, Cardiovascular system -- Surgery, Sex factors in disease -- Analysis, HIV patients -- Statistics -- Care and treatment -- Demographic aspects, Health
Abstract

: Introduction: There is paucity of data related to potential gender differences in the use of interventions to prevent and treat cardiovascular disease (CVD) among HIV‐positive individuals. We investigated whether such differences exist in the observational D:A:D cohort study. Methods: Participants were followed from study enrolment until the earliest of death, six months after last visit or February 1, 2015. Initiation of CVD interventions [lipid‐lowering drugs (LLDs), angiotensin‐converting enzyme inhibitors (ACEIs), anti‐hypertensives, invasive cardiovascular procedures (ICPs) were investigated and Poisson regression models calculated whether rates were lower among women than men, adjusting for potential confounders. Results: Women (n = 12,955) were generally at lower CVD risk than men (n = 36,094). Overall, initiation rates of CVD interventions were lower in women than men; LLDs: incidence rate 1.28 [1.21, 1.35] vs. 2.40 [2.34, 2.46]; ACEIs: 0.88 [0.82, 0.93] vs. 1.43 [1.39, 1.48]; anti‐hypertensives: 1.40 [1.33, 1.47] vs. 1.72 [1.68, 1.77] and ICPs: 0.08 [0.06, 0.10] vs. 0.30 [0.28, 0.32], and this was also true for most CVD interventions when exclusively considering periods of follow‐up for which individuals were at high CVD risk. In fully adjusted models, women were less likely to receive CVD interventions than men (LLDs: relative rate 0.83 [0.78, 0.88]; ACEIs: 0.93 [0.86, 1.01]; ICPs: 0.54 [0.43, 0.68]), except for the receipt of anti‐hypertensives (1.17 [1.10, 1.25]). Conclusion: The use of most CVD interventions was lower among women than men. Interventions are needed to ensure that all HIV‐positive persons, particularly women, are appropriately monitored for CVD and, if required, receive appropriate CVD interventions., Introduction HIV‐positive individuals are known to be at increased risk of cardiovascular disease (CVD) compared to the general population, partly due to an increased prevalence of some CVD risk factors, [...]

Published
2018
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106. Standard vocabulary, consensual functional groups and automated classification for phytoplankton high throughput datasets using automated flow cytometry

Author

Thyssen, Melilotus, Fuchs, Robin, Créach, Véronique, Artigas, Luis Felipe, Grégori, Gérald, Marrec, Pierre, DUGENNE, Mathilde, Rijkeboer, Machteld, Latimier, Marie, Arnaud, Louchart, Louchart, Arnaud, Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), and Thyssen, Melilotus

Subjects
[SDE] Environmental Sciences, [SDE]Environmental Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

112. Does Repeated Ticking Maintain Tic Behavior? An Experimental Study of Eye Blinking in Healthy Individuals

Author

Daniel J. V. Beetsma, Marcel A. van den Hout, Iris M. Engelhard, Marleen M. Rijkeboer, and Danielle C. Cath

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Tics in Tourette syndrome (TS) are often preceded by “premonitory urges”: annoying feelings or bodily sensations. We hypothesized that, by reducing annoyance of premonitory urges, tic behaviour may be reinforced. In a 2×2 experimental design in healthy participants, we studied the effects of premonitory urges (operationalized as air puffs on the eye) and tic behaviour (deliberate eye blinking after a puff or a sound) on changes in subjective evaluation of air puffs and EMG responses on the m. orbicularis oculi. The experimental group with air puffs + blinking experienced a decrease in subjective annoyance of the air puff, but habituation of the EMG response was blocked and length of EMG response increased. In the control groups (air puffs without instruction to blink, no air puffs), these effects were absent. When extrapolating to the situation in TS patients, these findings suggest that performance of tics is reinforced by reducing the subjective annoyance of premonitory urges, while simultaneously preventing habituation or even inducing sensitisation of the physiological motor response.

Published
2014
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114. Effects of Decontamination of the Oropharynx and Intestinal Tract on Antibiotic Resistance in ICUs: A Randomized Clinical Trial

Author

Oostdijk, Evelien A. N., Kesecioglu, Jozef, Schultz, Marcus J., Visser, Caroline E., de Jonge, Evert, van Essen, Einar H. R., Bernards, Alexandra T., Purmer, Ilse, Brimicombe, Roland, Bergmans, Dennis, van Tiel, Frank, Bosch, Frank H., Mascini, Ellen, van Griethuysen, Arjanne, Bindels, Alexander, Jansz, Arjan, van Steveninck, Fred (A.) L., van der Zwet, Wil C., Fijen, Jan Willem, Thijsen, Steven, de Jong, Remko, Oudbier, Joke, Raben, Adrienne, van der Vorm, Eric, Koeman, Mirelle, Rothbarth, Philip, Rijkeboer, Annemieke, Gruteke, Paul, Hart-Sweet, Helga, Peerbooms, Paul, Winsser, Lex J., van Elsacker-Niele, Anne-Marie W., Demmendaal, Kees, Brandenburg, Afke, de Smet, Anne Marie G.A., and Bonten, Marc J. M.

Published
2014
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116. Schematherapie bij een cliënte met een dissociatieve identiteitsstoornis

Author

van den Ouweland, Minou, Huntjens, Rafaele, Rijkeboer, Marleen M., Hornsveld, Hellen, Bögels, Hélène, Grandia, Heleen, and Experimental Psychotherapy & Psychopathology

Abstract

Ella is als kind veelvuldig misbruikt door haar vader. Op veertigjarige leeftijd is ze voor het eerst gaan praten over het misbruik en sindsdien heeft ze verschillende vormen van hulpverlening gehad. Na jarenlange behandeling voor haar posttraumatische-stressstoornis en dissociatieve identiteitsstoornis kampt ze nog steeds met een hoge lijdensdruk. Ella heeft veel chaos en drukte in haar hoofd door de acht verschillende identiteiten die ze ervaart. Ze hoort van haar behandelaar dat er een studie gestart wordt naar schematherapie bij dissociatieve identiteitsstoornis. Ze is gemotiveerd een nieuwe behandelmethodiek te proberen en neemt zelf contact op met de onderzoekers om als cliënt aan dit onderzoek deel te nemen. De behandeling verloopt volgens een behandelprotocol dat speciaal voor de studie werd geschreven en duurt drieënhalf jaar. In die periode werkt Ella hard aan het doorbreken van storende patronen en krijgt ze uiteindelijk meer rust in haar hoofd.

Published
2021

118. Some Patients Are More Equal Than Others: Variation in Ventilator Settings for Coronavirus Disease 2019 Acute Respiratory Distress Syndrome

Author

Dam, T.A., Grooth, H.J. de, Klausch, T., Fleuren, L.M., Bruin, D.P. de, Entjes, R., Rettig, T.C., Dongelmans, Dave A., Boelens, A.D., Rigter, S., Hendriks, S.H., Jong, R. de, Kamps, M.J., Peters, M., Karakus, A., Gommers, D., Ramnarain, D., Wils, E.J., Achterberg, S., Nowitzky, R., Tempel, W., Jager, C.P.C. de, Nooteboom, F., Oostdijk, E., Koetsier, P., Cornet, A.D., Reidinga, A.C., Ruijter, W. de, Bosman, R.J., Frenzel, T., Urlings-Strop, L.C., Jong, p de, Smit, Egbert F., Cremer, O.L., Mehagnoul-Schipper, D.J., Faber, H.J., Lens, J., Brunnekreef, G.B., Festen-Spanjer, B., Dormans, T., Dijkstra, A., Simons, B., Rijkeboer, A.A., Arbous, S., Aries, M., Beukema, M., Pretorius, D., Raalte, R. van, Tellingen, M. van, Oever, N.C. Gritters van de, Lalisang, R.C.A., Tonutti, M., Girbes, Armand R.J., Hoogendoorn, M., Thoral, P.J., Elbers, P.W.G., Dam, T.A., Grooth, H.J. de, Klausch, T., Fleuren, L.M., Bruin, D.P. de, Entjes, R., Rettig, T.C., Dongelmans, Dave A., Boelens, A.D., Rigter, S., Hendriks, S.H., Jong, R. de, Kamps, M.J., Peters, M., Karakus, A., Gommers, D., Ramnarain, D., Wils, E.J., Achterberg, S., Nowitzky, R., Tempel, W., Jager, C.P.C. de, Nooteboom, F., Oostdijk, E., Koetsier, P., Cornet, A.D., Reidinga, A.C., Ruijter, W. de, Bosman, R.J., Frenzel, T., Urlings-Strop, L.C., Jong, p de, Smit, Egbert F., Cremer, O.L., Mehagnoul-Schipper, D.J., Faber, H.J., Lens, J., Brunnekreef, G.B., Festen-Spanjer, B., Dormans, T., Dijkstra, A., Simons, B., Rijkeboer, A.A., Arbous, S., Aries, M., Beukema, M., Pretorius, D., Raalte, R. van, Tellingen, M. van, Oever, N.C. Gritters van de, Lalisang, R.C.A., Tonutti, M., Girbes, Armand R.J., Hoogendoorn, M., Thoral, P.J., and Elbers, P.W.G.

Abstract

Contains fulltext : 244701.pdf (Publisher’s version ) (Open Access), OBJECTIVES: As coronavirus disease 2019 is a novel disease, treatment strategies continue to be debated. This provides the intensive care community with a unique opportunity as the population of coronavirus disease 2019 patients requiring invasive mechanical ventilation is relatively homogeneous compared with other ICU populations. We hypothesize that the novelty of coronavirus disease 2019 and the uncertainty over its similarity with noncoronavirus disease 2019 acute respiratory distress syndrome resulted in substantial practice variation between hospitals during the first and second waves of coronavirus disease 2019 patients. DESIGN: Multicenter retrospective cohort study. SETTING: Twenty-five hospitals in the Netherlands from February 2020 to July 2020, and 14 hospitals from August 2020 to December 2020. PATIENTS: One thousand two hundred ninety-four critically ill intubated adult ICU patients with coronavirus disease 2019 were selected from the Dutch Data Warehouse. Patients intubated for less than 24 hours, transferred patients, and patients still admitted at the time of data extraction were excluded. MEASUREMENTS AND MAIN RESULTS: We aimed to estimate between-ICU practice variation in selected ventilation parameters (positive end-expiratory pressure, Fio(2), set respiratory rate, tidal volume, minute volume, and percentage of time spent in a prone position) on days 1, 2, 3, and 7 of intubation, adjusted for patient characteristics as well as severity of illness based on Pao(2)/Fio(2) ratio, pH, ventilatory ratio, and dynamic respiratory system compliance during controlled ventilation. Using multilevel linear mixed-effects modeling, we found significant (p ≤ 0.001) variation between ICUs in all ventilation parameters on days 1, 2, 3, and 7 of intubation for both waves. CONCLUSIONS: This is the first study to clearly demonstrate significant practice variation between ICUs related to mechanical ventilation parameters that are under direct control by intensivists.

Published
2021

119. Towards a reformulated theory underlying schema therapy: Position paper of an international workgroup

Author

Arntz, A., Rijkeboer, M., Chan, E., Fassbinder, E., Karaosmanoglu, A., Lee, C.W., Panzeri, M., Arntz, A., Rijkeboer, M., Chan, E., Fassbinder, E., Karaosmanoglu, A., Lee, C.W., and Panzeri, M.

Abstract

Background A central construct in Schema Therapy (ST) is that of a schema mode, describing the current emotional-cognitive-behavioral state. Initially, 10 modes were described. Over time, with the world-wide increasing and broader application of ST to various disorders, additional schema modes were identified, mainly based on clinical impressions. Thus, the need for a new, theoretically based, cross-cultural taxonomy of modes emerged. Methods An international workgroup started from scratch to identify an extensive taxonomy of modes, based on (a) extending the theory underlying ST with new insights on needs, and (b) recent research on ST theory supporting that modes represent combinations of activated schemas and coping. Results We propose to add two emotional needs to the original five core needs that theoretically underpin the development of early maladaptive schemas (EMSs), i.e., the need for Self-Coherence, and the need for Fairness, leading to three new EMSs, i.e. Lack of a Coherent Identity, Lack of a Meaningful World, and Unfairness. When rethinking the purpose behind the different ways of coping with EMS-activation, we came up with new labels for two of those: Resignation instead of Surrender, and Inversion instead of Overcompensation. By systematically combining EMSs and ways of coping we derived a set of schema modes that can be empirically tested. Conclusions With this project, we hope to contribute to the further development of ST and its application across the world.

Published
2021

120. Some Patients Are More Equal Than Others: Variation in Ventilator Settings for Coronavirus Disease 2019 Acute Respiratory Distress Syndrome

Author

Dam, Tariq A, Dam, Tariq A, de Grooth, Harm-Jan, Klausch, Thomas, Fleuren, Lucas M, de Bruin, Daan P, Entjes, Robert, Rettig, Thijs C D, Dongelmans, Dave A, Boelens, Age D, Rigter, Sander, Hendriks, Stefaan H A, de Jong, Remko, Kamps, Marlijn J A, Peters, Marco, Karakus, A, Gommers, Diederik, Ramnarain, Dharmanand, Wils, Evert-Jan, Achterberg, Sefanja, Nowitzky, Ralph, van den Tempel, Walter, de Jager, Cornelis P C, Nooteboom, Fleur G C A, Oostdijk, Evelien, Koetsier, Peter, Cornet, Alexander D, Reidinga, Auke C, de Ruijter, Wouter, Bosman, Rob J, Frenzel, Tim, Urlings-Strop, Louise C, de Jong, Paul, Smit, Ellen G M, Cremer, Olaf L, Mehagnoul-Schipper, D Jannet, Faber, Harald J, Lens, Judith, Brunnekreef, Gert B, Festen-Spanjer, Barbara, Dormans, Tom, Dijkstra, Annemieke, Simons, Bram, Rijkeboer, A A, Arbous, Sesmu, Aries, Marcel, Beukema, Menno, Pretorius, Daniël, van Raalte, Rutger, van Tellingen, Martijn, Gritters van den Oever, Niels C, Lalisang, Robbert C A, Tonutti, Michele, Girbes, Armand R J, Hoogendoorn, Mark, Thoral, Patrick J, Elbers, Paul W G, Dam, Tariq A, Dam, Tariq A, de Grooth, Harm-Jan, Klausch, Thomas, Fleuren, Lucas M, de Bruin, Daan P, Entjes, Robert, Rettig, Thijs C D, Dongelmans, Dave A, Boelens, Age D, Rigter, Sander, Hendriks, Stefaan H A, de Jong, Remko, Kamps, Marlijn J A, Peters, Marco, Karakus, A, Gommers, Diederik, Ramnarain, Dharmanand, Wils, Evert-Jan, Achterberg, Sefanja, Nowitzky, Ralph, van den Tempel, Walter, de Jager, Cornelis P C, Nooteboom, Fleur G C A, Oostdijk, Evelien, Koetsier, Peter, Cornet, Alexander D, Reidinga, Auke C, de Ruijter, Wouter, Bosman, Rob J, Frenzel, Tim, Urlings-Strop, Louise C, de Jong, Paul, Smit, Ellen G M, Cremer, Olaf L, Mehagnoul-Schipper, D Jannet, Faber, Harald J, Lens, Judith, Brunnekreef, Gert B, Festen-Spanjer, Barbara, Dormans, Tom, Dijkstra, Annemieke, Simons, Bram, Rijkeboer, A A, Arbous, Sesmu, Aries, Marcel, Beukema, Menno, Pretorius, Daniël, van Raalte, Rutger, van Tellingen, Martijn, Gritters van den Oever, Niels C, Lalisang, Robbert C A, Tonutti, Michele, Girbes, Armand R J, Hoogendoorn, Mark, Thoral, Patrick J, and Elbers, Paul W G

Abstract

OBJECTIVES: As coronavirus disease 2019 is a novel disease, treatment strategies continue to be debated. This provides the intensive care community with a unique opportunity as the population of coronavirus disease 2019 patients requiring invasive mechanical ventilation is relatively homogeneous compared with other ICU populations. We hypothesize that the novelty of coronavirus disease 2019 and the uncertainty over its similarity with noncoronavirus disease 2019 acute respiratory distress syndrome resulted in substantial practice variation between hospitals during the first and second waves of coronavirus disease 2019 patients.DESIGN: Multicenter retrospective cohort study.SETTING: Twenty-five hospitals in the Netherlands from February 2020 to July 2020, and 14 hospitals from August 2020 to December 2020.PATIENTS: One thousand two hundred ninety-four critically ill intubated adult ICU patients with coronavirus disease 2019 were selected from the Dutch Data Warehouse. Patients intubated for less than 24 hours, transferred patients, and patients still admitted at the time of data extraction were excluded.MEASUREMENTS AND MAIN RESULTS: We aimed to estimate between-ICU practice variation in selected ventilation parameters (positive end-expiratory pressure, Fio2, set respiratory rate, tidal volume, minute volume, and percentage of time spent in a prone position) on days 1, 2, 3, and 7 of intubation, adjusted for patient characteristics as well as severity of illness based on Pao2/Fio2 ratio, pH, ventilatory ratio, and dynamic respiratory system compliance during controlled ventilation. Using multilevel linear mixed-effects modeling, we found significant (p ≤ 0.001) variation between ICUs in all ventilation parameters on days 1, 2, 3, and 7 of intubation for both waves.CONCLUSIONS: This is the first study to clearly demonstrate significant practice variation between ICUs related to mechanical ventilation parameters that are under dire

Published
2021

121. Schematherapie bij een cliënte met een dissociatieve identiteitsstoornis

Author

Hornsveld, Hellen, Bögels, Hélène, Grandia, Heleen, van den Ouweland, Minou, Huntjens, Rafaele, Rijkeboer, Marleen M., Hornsveld, Hellen, Bögels, Hélène, Grandia, Heleen, van den Ouweland, Minou, Huntjens, Rafaele, and Rijkeboer, Marleen M.

Abstract

Ella is als kind veelvuldig misbruikt door haar vader. Op veertigjarige leeftijd is ze voor het eerst gaan praten over het misbruik en sindsdien heeft ze verschillende vormen van hulpverlening gehad. Na jarenlange behandeling voor haar posttraumatische-stressstoornis en dissociatieve identiteitsstoornis kampt ze nog steeds met een hoge lijdensdruk. Ella heeft veel chaos en drukte in haar hoofd door de acht verschillende identiteiten die ze ervaart. Ze hoort van haar behandelaar dat er een studie gestart wordt naar schematherapie bij dissociatieve identiteitsstoornis. Ze is gemotiveerd een nieuwe behandelmethodiek te proberen en neemt zelf contact op met de onderzoekers om als cliënt aan dit onderzoek deel te nemen. De behandeling verloopt volgens een behandelprotocol dat speciaal voor de studie werd geschreven en duurt drieënhalf jaar. In die periode werkt Ella hard aan het doorbreken van storende patronen en krijgt ze uiteindelijk meer rust in haar hoofd.

Published
2021

122. Some Patients Are More Equal Than Others:Variation in Ventilator Settings for Coronavirus Disease 2019 Acute Respiratory Distress Syndrome

Author

Dam, Tariq A, de Grooth, Harm-Jan, Klausch, Thomas, Fleuren, Lucas M, de Bruin, Daan P, Entjes, Robert, Rettig, Thijs C D, Dongelmans, Dave A, Boelens, Age D, Rigter, Sander, Hendriks, Stefaan H A, de Jong, Remko, Kamps, Marlijn J A, Peters, Marco, Karakus, A, Gommers, Diederik, Ramnarain, Dharmanand, Wils, Evert-Jan, Achterberg, Sefanja, Nowitzky, Ralph, van den Tempel, Walter, de Jager, Cornelis P C, Nooteboom, Fleur G C A, Oostdijk, Evelien, Koetsier, Peter, Cornet, Alexander D, Reidinga, Auke C, de Ruijter, Wouter, Bosman, Rob J, Frenzel, Tim, Urlings-Strop, Louise C, de Jong, Paul, Smit, Ellen G M, Cremer, Olaf L, Mehagnoul-Schipper, D Jannet, Faber, Harald J, Lens, Judith, Brunnekreef, Gert B, Festen-Spanjer, Barbara, Dormans, Tom, Dijkstra, Annemieke, Simons, Bram, Rijkeboer, A A, Arbous, Sesmu, Aries, Marcel, Beukema, Menno, Pretorius, Daniël, van Raalte, Rutger, van Tellingen, Martijn, Gritters van den Oever, Niels C, Lalisang, Robbert C A, Tonutti, Michele, Girbes, Armand R J, Hoogendoorn, Mark, Thoral, Patrick J, Elbers, Paul W G, Dam, Tariq A, de Grooth, Harm-Jan, Klausch, Thomas, Fleuren, Lucas M, de Bruin, Daan P, Entjes, Robert, Rettig, Thijs C D, Dongelmans, Dave A, Boelens, Age D, Rigter, Sander, Hendriks, Stefaan H A, de Jong, Remko, Kamps, Marlijn J A, Peters, Marco, Karakus, A, Gommers, Diederik, Ramnarain, Dharmanand, Wils, Evert-Jan, Achterberg, Sefanja, Nowitzky, Ralph, van den Tempel, Walter, de Jager, Cornelis P C, Nooteboom, Fleur G C A, Oostdijk, Evelien, Koetsier, Peter, Cornet, Alexander D, Reidinga, Auke C, de Ruijter, Wouter, Bosman, Rob J, Frenzel, Tim, Urlings-Strop, Louise C, de Jong, Paul, Smit, Ellen G M, Cremer, Olaf L, Mehagnoul-Schipper, D Jannet, Faber, Harald J, Lens, Judith, Brunnekreef, Gert B, Festen-Spanjer, Barbara, Dormans, Tom, Dijkstra, Annemieke, Simons, Bram, Rijkeboer, A A, Arbous, Sesmu, Aries, Marcel, Beukema, Menno, Pretorius, Daniël, van Raalte, Rutger, van Tellingen, Martijn, Gritters van den Oever, Niels C, Lalisang, Robbert C A, Tonutti, Michele, Girbes, Armand R J, Hoogendoorn, Mark, Thoral, Patrick J, and Elbers, Paul W G

Abstract

OBJECTIVES: As coronavirus disease 2019 is a novel disease, treatment strategies continue to be debated. This provides the intensive care community with a unique opportunity as the population of coronavirus disease 2019 patients requiring invasive mechanical ventilation is relatively homogeneous compared with other ICU populations. We hypothesize that the novelty of coronavirus disease 2019 and the uncertainty over its similarity with noncoronavirus disease 2019 acute respiratory distress syndrome resulted in substantial practice variation between hospitals during the first and second waves of coronavirus disease 2019 patients.DESIGN: Multicenter retrospective cohort study.SETTING: Twenty-five hospitals in the Netherlands from February 2020 to July 2020, and 14 hospitals from August 2020 to December 2020.PATIENTS: One thousand two hundred ninety-four critically ill intubated adult ICU patients with coronavirus disease 2019 were selected from the Dutch Data Warehouse. Patients intubated for less than 24 hours, transferred patients, and patients still admitted at the time of data extraction were excluded.MEASUREMENTS AND MAIN RESULTS: We aimed to estimate between-ICU practice variation in selected ventilation parameters (positive end-expiratory pressure, Fio2, set respiratory rate, tidal volume, minute volume, and percentage of time spent in a prone position) on days 1, 2, 3, and 7 of intubation, adjusted for patient characteristics as well as severity of illness based on Pao2/Fio2 ratio, pH, ventilatory ratio, and dynamic respiratory system compliance during controlled ventilation. Using multilevel linear mixed-effects modeling, we found significant (p ≤ 0.001) variation between ICUs in all ventilation parameters on days 1, 2, 3, and 7 of intubation for both waves.CONCLUSIONS: This is the first study to clearly demonstrate significant practice variation between ICUs related to mechanical ventilation parameters that are under dire

Published
2021

125. Validation of Schema Coping Inventory and Schema Mode Inventory in Adolescents

Author

Arnoud Arntz, Jeffrey Roelofs, Marjolein F. Van Wijk-Herbrink, David P. Bernstein, Nick J. Broers, Marleen M. Rijkeboer, Section Forensic Psychology, RS: FPN CPS IV, RS: FPN CPS III, Section Clinical Psychology, FPN Methodologie & Statistiek, RS: FPN M&S I, and Klinische Psychologie (Psychologie, FMG)

Subjects
Male, 050103 clinical psychology, Coping (psychology), Adolescent, Personality Inventory, Psychometrics, medicine.medical_treatment, education, Validity, Behavioral Symptoms, Developmental psychology, 03 medical and health sciences, 0302 clinical medicine, health services administration, Schema (psychology), Adaptation, Psychological, mental disorders, Journal Article, medicine, Humans, natural sciences, 0501 psychology and cognitive sciences, Defense Mechanisms, Schema therapy, 05 social sciences, Reproducibility of Results, equipment and supplies, 030227 psychiatry, Psychiatry and Mental health, Clinical Psychology, Adolescent Behavior, Female, Psychology
Abstract

This study investigated whether the schema therapy constructs of schema coping and schema modes have val dity in adolescents. We examined the validity and reliability of the Schema Coping Inventory (SCI) and an 80-item version of the Schema Mode Inventory (SMI) in a mixed sample of adolescents. Confirmatory factor analyse showed that the first-order factor structures of the SCI and SMI were replicated, but that the hypothesized higher-order models of the SMI were not confirmed. Instead, we proposed an alternative higher-order model of Internalizing, Externalizing, Overachieving, and Healthy modes. In general, the SCI and SMI scales were able o distinguish the clinical sample from the community sample, and meaningful relationships were found between oping styles, schema modes, and behavior problems. In conclusion, our study supports the theorized relations ips between schema coping styles, schema modes, and behavior, problems in adolescents, and provides initial validation for the SCI and the, 80-item SMI in adolescent populations.

Published
2018
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130. Examining the effect of stress on the flexible updating of avoidance responses.

Author

Lemmens, Anke, Quaedflieg, Conny W. E. M., Dibbets, Pauline, Rijkeboer, Marleen, and Smeets, Tom

Subjects
OPERANT conditioning, AVERSIVE stimuli, STIMULUS & response (Psychology), HYDROCORTISONE, ACUTE stress disorder
Abstract

Acute stress has been found to impair the flexible updating of stimulus − outcome associations. However, there is a lack of studies investigating the effect of acute stress on the flexible updating of stimulus–response associations, like active avoidance responses. The current study used an avoidance reversal learning paradigm to address this question. Sixty‐one participants learned that a red dot was associated with an aversive sound, whereas a green dot was not (Pavlovian Acquisition phase). Next, they were trained to avoid the aversive stimulus by selectively pressing a button in response to the red, but not the green, dot (Avoidance Acquisition phase). Subsequently, participants either underwent a stress induction task or a no‐stress control task. The flexible updating of expectancies of the US and avoidance responses were assessed after reversal of the original contingencies (Reversal Test). Acute stress did not impair the flexible updating of avoidance responses during the Reversal Test. In contrast, results showed that in the stress group the expectancies of the aversive sound were more in accordance with the reversed contingencies compared to the ratings of control participants. Additionally, cortisol responders avoided less often in comparison to cortisol non‐responders. Increased noradrenergic activity in stressed participants was related to impairments in the flexible updating of avoidance responses after contingency reversal, while this association was absent in the control participants. In conclusion, our results suggest that the autonomic response might account for shifting the balance toward inflexible updating of stimulus–outcome awareness while stress does not impair flexible updating of avoidance responses. [ABSTRACT FROM AUTHOR]

Published
2022
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133. Imagery rescripting and eye movement desensitisation and reprocessing as treatment for adults with post-traumatic stress disorder from childhood trauma: randomised clinical trial

Author

Boterhoven de Haan, Katrina L., primary, Lee, Christopher W., additional, Fassbinder, Eva, additional, van Es, Saskia M., additional, Menninga, Simone, additional, Meewisse, Marie-Louise, additional, Rijkeboer, Marleen, additional, Kousemaker, Margriet, additional, and Arntz, Arnoud, additional

Published
2020
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137. Optical teledetection of a chlorophyll a in estuarine in coastal waters

Author

Gons, Herman J., Rijkeboer, Machteld, Bagheri, Sima, and Ruddick, Kevin G.

Subjects
Chlorophyll -- Research, Water pollution -- Research, Pollution control industry -- Research, Environmental issues, Science and technology
Abstract

In this study, subsurface spectral irradiance reflectance was examined in three different regions in the US and the Netherlands using a hand-held spectroradiometer. The study was broken down into an introduction, a discussion of the experiment and its results. Various tables and graphs accompany the article.

Published
2000

139. Differential Effects of Comorbid Psychiatric Disorders on Treatment Outcome in Posttraumatic Stress Disorder from Childhood Trauma

Author

Marleen M. Rijkeboer, Anja Schaich, Katrina L. Boterhoven de Haan, Arnoud Arntz, Eva Fassbinder, Christopher W. Lee, Nele Assmann, Section Clinical Psychology, RS: FPN CPS III, Psychology Other Research (FMG), and Klinische Psychologie (Psychologie, FMG)

Subjects
medicine.medical_specialty, medicine.medical_treatment, Treatment outcome, posttraumatic stress disorder, depression, anxiety disorder, therapy, prediction, moderator, treatment outcome, behavioral disciplines and activities, Article, PSYCHOTHERAPY, mental disorders, Eye movement desensitization and reprocessing, medicine, EXPOSURE, PREDICTORS, Psychiatry, Depression (differential diagnoses), RISK, business.industry, PTSD, MAJOR DEPRESSION, REMISSION, General Medicine, Moderation, medicine.disease, Posttraumatic stress, PATTERNS, Medicine, Major depressive disorder, Anxiety, EYE-MOVEMENTS, medicine.symptom, business, Anxiety disorder
Abstract

Patients with posttraumatic stress disorder (PTSD) frequently have comorbid diagnoses such as major depressive disorder (MDD) and anxiety disorders (AD). Studies into the impact of these comorbidities on the outcome of PTSD treatment have yielded mixed results. The different treatments investigated in these studies might explain the varied outcome. The purpose of this study was to examine the impact of these comorbidities on the outcome of two specific PTSD treatments. MDD and AD were analyzed as predictors and moderators in a trial comparing 12 sessions of either eye movement desensitization and reprocessing (EMDR) or imagery rescripting (IR) in 155 adult patients with PTSD from childhood trauma. The primary outcome was reduction of PTSD symptoms (clinician-administered PTSD Scale for DSM-5, CAPS-5) assessed at eight-week follow-up and a secondary outcome was self-report PTSD symptoms (Impact of Event Scale, IES-R). MDD was not a predictor of treatment outcome but did have a significant moderator effect. Patients with MDD showed a better outcome if they were treated with IR, whereas patients without MDD improved more in the EMDR condition. No impact of AD emerged. It seems essential to consider comorbid MDD when planning PTSD treatment to improve treatment outcomes. More research is needed to replicate our findings and focus on different kinds of PTSD treatments and other comorbidities.

Published
2021
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143. Werkingsmechanismen

Author

Greeven, A., van Emmerik, A., Rijkeboer, M., Klinische Psychologie (Psychologie, FMG), and Psychology Other Research (FMG)

Published
2020

144. Comparing flow cytometry and microscopy in the quantification of vital aquatic organisms in ballast water

Author

George B.J. Dubelaar, Brian N Maurer, Albert Mosselaar, Eva-Maria Zetsche, Louis Peperzak, Stephan Gollasch, Aud Larsen, Joël Henneghien, August Tobiesen, Ole-Kristian Hess-Erga, Pieter de Vré, Véronique Créach, Luis Felipe Artigas, Roland Langelaar, Euan D. Reavie, M. Rijkeboer, and Simon Bonato

Subjects
0106 biological sciences, Ballast, medicine.diagnostic_test, 010604 marine biology & hydrobiology, Environmental chemistry, Microscopy, medicine, Environmental science, Ocean Engineering, 010603 evolutionary biology, 01 natural sciences, Aquatic organisms, Flow cytometry
Abstract

The ability to quantify vital aquatic organisms in the 2–50 µm size range was compared between five different flow cytometers and several different microscopes. Counts of calibration beads, algal monocultures of different sizes as well as organisms in a Wadden Sea sample were compared. Flow cytometers and microscopes delivered different bead concentrations. These differences between the instruments became larger for algal monocultures and were even higher for the Wadden Sea sample. It was observed that the concentration differences were significant between flow cytometer and microscope counts, and that this difference increased with the size of the objects counted. Microscope counts were more accurate for larger (50 µm) objects because cytometers struggled with bigger particles that clogged the instruments. Contrary to microscopy, the flow cytometers were capable of accurately enumerating cultured cells in the 2–10 µm size range and cells in the lower size range of the 10–50 µm size class. Flow cytometers were also well-suited to assess low abundance samples due to their ability to process larger volumes than microscopes. The results were used to indicate which tools are suitable for ballast water monitoring: flow cytometry is a suitable technology for an indicative and real time analysis of ballast water samples whilst only microscopy would be robust enough for detailed taxonomical analyses.

Published
2020

147. Melioidosis in travelers : An analysis of Dutch melioidosis registry data 1985–2018

Author

Emma Birnie, Jelmer Savelkoel, Frans Reubsaet, Joris J.T.H. Roelofs, Robin Soetekouw, Saskia Kolkman, Anne Lia Cremers, Martin P. Grobusch, Daan W. Notermans, W. Joost Wiersinga, Wouter Rozemeijer, Annemieke Rijkeboer, Maarten Scholing, Karin van Dijk, Ellen M. Mascini, Henk van der Veen, Wouter van den Bijllaardt, Maaike de Vries, Leonard C. Smeets, Alewijn Ott, Kees van Krimpen, Bjorn L. Herpers, G. Hanke Watttel-Louis, Karola Waar, Noortje L.Q. Schwandt, Ianthe Maat, Anthonius S.M. Dofferhoff, Joost N. Vermeulen, Mireille van Westreenen, Peter de Man, Regina W. Hofland, Joost van Gorp, Steven Thijsen, Lieven B. van der Velden, Cornelis M. Verduin, Medical Microbiology & Infectious Diseases, Graduate School, AII - Infectious diseases, APH - Aging & Later Life, APH - Global Health, Center of Experimental and Molecular Medicine, Pathology, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, Radiology and Nuclear Medicine, Infectious diseases, Medical Microbiology and Infection Prevention, and APH - Quality of Care

Subjects
medicine.medical_specialty, Melioidosis, Burkholderia pseudomallei, Fever in returned travelers, Opportunistic infection, 030231 tropical medicine, Sepsis, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Internal medicine, medicine, Journal Article, Travel medicine, 030212 general & internal medicine, Surveillance, biology, Septic shock, business.industry, Environmental and Occupational Health, Public Health, Environmental and Occupational Health, medicine.disease, biology.organism_classification, Pneumonia, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Otitis, Infectious Diseases, Public Health, medicine.symptom, business
Abstract

Background: Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an opportunistic infection across the tropics. Here, we provide a systematic overview of imported human cases in a non-endemic country over a 25-year period. Methods: All 55 Dutch microbiology laboratories were contacted in order to identify all B. pseudomallei positive cultures from 1990 to 2018. A response rate of 100% was achieved. Additionally, a systematic literature search was performed, medical-charts reviewed, and tissue/autopsy specimens were re-assessed. Results: Thirty-three travelers with melioidosis were identified: 70% male with a median-age of 54 years. Risk factors were present in most patients (n = 23, 70%), most notably diabetes (n = 8, 24%) and cystic fibrosis (n = 3, 9%). Countries of acquisition included Thailand, Brazil, Indonesia, Panama, and The Gambia. Disease manifestations included pneumonia, intra-abdominal abscesses, otitis externa, genitourinary, skin-, CNS-, and thyroid gland infections. Twelve (36%) patients developed sepsis and/or septic shock. Repeat episodes of active infection were observed in five (15%) and mortality in four (12%) patients. Post-mortem analysis showed extensive metastatic (micro)abscesses amongst other sites in the adrenal gland and bone marrow. Conclusions: The number of imported melioidosis is likely to increase, given rising numbers of (immunocompromised) travelers, and increased vigilance of the condition. This first systematic retrospective surveillance study in a non-endemic melioidosis country shows that imported cases can serve as sentinels to provide information about disease activity in areas visited and inform pre-travel advice and post-travel clinical management.

Published
2019

148. Jongeren met gedragsproblemen: Schematherapie en behandelfocus

Author

van Wijk-Herbrink, M., Bernstein, D., Broers, N., Roelofs, J., Rijkeboer, M., Arntz, A., and Klinische Psychologie (Psychologie, FMG)

Abstract

Jongeren met gedragsproblemen krijgen vaak afwijzende of bestraffende reacties op hun gedrag, terwijl hun gedrag juist voortkomt uit ervaringen met onverbondenheid en afwijzing (vicieuze cirkel). Dit blijkt uit een recent wetenschappelijk onderzoek (van Wijk-Herbrink et al., 2018), waarbij in een steekproef van 699 jongeren de verbanden zijn onderzocht tussen vroege onaangepaste schema's, coping, schemamodi en gedragsproblemen. Aan de hand van een casus geven wij hier een vertaling van dit onderzoek naar de klinische praktijk. We concluderen dat de behandelfocus voor jongeren met gedragsproblemen moet liggen op onderliggende schema's en bijbehorende behoeften aan verbondenheid en acceptatie, en op de schemamodi die door deze schema's worden geactiveerd. Schematherapie is een veelbelovende behandeling voor deze doelgroep. In de discussie geven we aan de hand van de casus enkele voorbeelden en illustraties van schematherapeutische technieken.

Published
2019

150. Comparing flow cytometry and microscopy in the quantification of vital aquatic organisms in ballast water

Author

Peperzak, L., Zetsche, E.-M., Gollasch, S., Artigas, L.F., Bonato, S., Creach, V., de Vré, P., Dubelaar, G.B.J., Henneghien, J., Hess-Erga, O.-K., Langelaar, R., Larsen, A., Maurer, B.N., Mosselaar, A., Reavie, E.D., Rijkeboer, M., Tobiesen, A., Peperzak, L., Zetsche, E.-M., Gollasch, S., Artigas, L.F., Bonato, S., Creach, V., de Vré, P., Dubelaar, G.B.J., Henneghien, J., Hess-Erga, O.-K., Langelaar, R., Larsen, A., Maurer, B.N., Mosselaar, A., Reavie, E.D., Rijkeboer, M., and Tobiesen, A.

Abstract

The ability to quantify vital aquatic organisms in the 2–50 µm size range was compared between five different flow cytometers and several different microscopes. Counts of calibration beads, algal monocultures of different sizes as well as organisms in a Wadden Sea sample were compared. Flow cytometers and microscopes delivered different bead concentrations. These differences between the instruments became larger for algal monocultures and were even higher for the Wadden Sea sample. It was observed that the concentration differences were significant between flow cytometer and microscope counts, and that this difference increased with the size of the objects counted. Microscope counts were more accurate for larger (50 µm) objects because cytometers struggled with bigger particles that clogged the instruments. Contrary to microscopy, the flow cytometers were capable of accurately enumerating cultured cells in the 2–10 µm size range and cells in the lower size range of the 10–50 µm size class. Flow cytometers were also well-suited to assess low abundance samples due to their ability to process larger volumes than microscopes. The results were used to indicate which tools are suitable for ballast water monitoring: flow cytometry is a suitable technology for an indicative and real time analysis of ballast water samples whilst only microscopy would be robust enough for detailed taxonomical analyses.

Published
2020

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