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Lung cancer is the leading cause of cancer-related death worldwide, with approximately 1.2 million deaths annually. The standard-of-care in patients with advanced disease is platinum-based doublet chemotherapy. Recent advances in the understanding of biological mechanisms of tumor growth have allowed for identification of some molecular targets for cancer treatment, such as vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR). VEGF is a pro-angiogenetic factor, which binds membrane receptors, and whose intra-cytoplasmatic domain presents tyrosine kinase activity. Pathological angiogenesis promotes tumor growth and metastasis. Targeted action against angiogenesis can lead to regression or normalization of neovascular structures and to inhibition of new blood vessel growth. The most commonly used mechanism is mediated by bevacizumab, a monoclonal antibody that selectively binds to VEGF and prevents interaction with its receptor. Currently bevacizumab is the only anti-angiogenic agent approved for the first-line treatment of non-small cell lung cancer (NSCLC) in selected patients. In the present review, we discuss the most important trials that demonstrate the efficacy and safety of bevacizumab. We also present an overview of the types of patients eligible for this treatment and a cost-effectiveness analysis. In conclusion, the possibility of administering a treatment with bevacizumab must be carefully analyzed case by case. It is important to identify those patients who can really benefit from the use of this drug, through the identification of specific response markers.

Nowadays, in order to be competitive on the market, it is fundamental to design optimized devices. This is especially true in the Offshore sector where the product’s weight has a material influence on all operations. Reducing this parameter implies a significant decrease in the project’s cost. This paper proposes the study of the kinematic rotation of a prototype machine required to lay down an umbilical system, needed to provide the vital supply (electricity and fiber optic) from platforms or topside vessel to subsea oil and gas furniture. In this paper, it will be proposed a solution for the delivery of a 600 mm external diameter umbilical product. In the studied case, the Client asked to have a cable that partially floats once it reaches the sea water showing incredible benefits such as the possibility to be replaced and small umbilical deflections due to a catenary effect reduction. Due to this singular request, the proposed prototype machine – characterized by the rotation of an articulated parallelogram, activated by two main pistons – ensures safety operation and integrity of the laid umbilical. Starting from an accurate structural analysis, a reliable model has been created and a first solution of the forces distribution along the chute elements has been found, highlighting some significant points (static configurations during a dynamic evolution). During the piston design phase, some limitations of current DNV standards (when dealing with offshore technologies) have been highlighted. To investigate this peculiar phenomenon several results obtained by different numerical approaches are proposed. The present machine could be even applied in the renewable energy field, for connecting wind turbines in the wind farm’s hub and then to carry the produced energy on shore. This analysis results in a 15% machine weight reduction with respect to the initial design. Such simulation provided a practical design tool for the Offshore market.